{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:56:00Z","timestamp":1790193360507,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd007286.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000}}],"reference-count":48,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007286.pub5","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T10:13:31Z","timestamp":1588068811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Antiepileptic drugs as prophylaxis for postcraniotomy seizures"],"prefix":"10.1002","author":[{"given":"Janette","family":"Greenhalgh","sequence":"additional","affiliation":[{"name":"Liverpool Reviews and Implementation Group; University of Liverpool; Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Weston","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology; Institute of Translational Medicine, University of Liverpool; Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenal","family":"Dundar","sequence":"additional","affiliation":[{"name":"Liverpool Reviews and Implementation Group; University of Liverpool; Liverpool UK"},{"name":"Central Queensland Hospital and Health Service; Rockhampton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J","family":"Nevitt","sequence":"additional","affiliation":[{"name":"Department of Biostatistics; University of Liverpool; Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G","family":"Marson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology; Institute of Translational Medicine, University of Liverpool; Liverpool UK"},{"name":"The Walton Centre NHS Foundation Trust; Liverpool UK"},{"name":"Liverpool Health Partners; Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"issue":"4","key":"10.1002\/14651858.CD007286.pub5-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1136\/jnnp.67.4.474","article-title":"Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects","volume":"67","author":"Beenen","year":"1999","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"9","key":"10.1002\/14651858.CD007286.pub5-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/jnnp.55.9.753","article-title":"Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?","volume":"55","author":"Foy","year":"1992","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"3-4","key":"10.1002\/14651858.CD007286.pub5-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF01401812","article-title":"The effectiveness of prophylactic anticonvulsants following neurosurgery","volume":"69","author":"Shaw","year":"1983","journal-title":"Acta Neurochirurgica"},{"issue":"1-2","key":"10.1002\/14651858.CD007286.pub5-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01420191","article-title":"Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours","volume":"103","author":"Franceschetti","year":"1990","journal-title":"Acta Neurochirurgica"},{"issue":"1","key":"10.1002\/14651858.CD007286.pub5-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1528-1167.2012.03563.x","article-title":"Tolerability, safety, and side effects of levetiracetam versus phenytoin in intravenous and total prophylactic regimen among craniotomy patients: a prospective randomized study","volume":"54","author":"Fuller","year":"2013","journal-title":"Epilepsia"},{"issue":"10","key":"10.1002\/14651858.CD007286.pub5-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1136\/jnnp-2014-308584","article-title":"Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours: a phase II prospective, randomised study","volume":"86","author":"Iuchi","year":"2015","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"5","key":"10.1002\/14651858.CD007286.pub5-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0090-3019(89)90067-0","article-title":"Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures","volume":"31","author":"Lee","year":"1989","journal-title":"Surgical Neurology"},{"issue":"10","key":"10.1002\/14651858.CD007286.pub5-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.7887\/jcns.8.647","article-title":"A randomized controlled trial of zonisamide in postoperative epilepsy: a report of the Cooperative Group Study","volume":"8","author":"Nakamura","year":"1999","journal-title":"Japanese Journal of Neurosurgery"},{"issue":"5","key":"10.1002\/14651858.CD007286.pub5-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3171\/jns.1983.58.5.0672","article-title":"Phenytoin and postoperative epilepsy. A double-blind study","volume":"58","author":"North","year":"1983","journal-title":"Journal of Neurosurgery"},{"issue":"8165","key":"10.1002\/14651858.CD007286.pub5-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0140-6736(80)90941-1","article-title":"Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy","volume":"1","author":"North","year":"1980","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD007286.pub5-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3171\/2012.12.JNS111970","article-title":"A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumours","volume":"118","author":"Wu","year":"2013","journal-title":"Journal of Neurosurgery"},{"issue":"4","key":"10.1002\/14651858.CD007286.pub5-BIB0012|cit12","first-page":"231","article-title":"Phenytoin or sodium valproate for prophylaxis of postoperative epilepsy: a randomised comparison","volume":"26","author":"Zhang","year":"2000","journal-title":"Chinese Journal of Nervous and Mental Diseases"},{"issue":"5","key":"10.1002\/14651858.CD007286.pub5-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1227\/00006123-199511000-00003","article-title":"Short-term perioperative anticonvulsant prophylaxis for the surgical treatment of low-risk patients with intracranial aneurysms","volume":"37","author":"Baker","year":"1995","journal-title":"Neurosurgery"},{"issue":"3","key":"10.1002\/14651858.CD007286.pub5-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1227\/00006123-198503000-00002","article-title":"Postoperative prophylactic anticonvulsant therapy in cerebral gliomas","volume":"16","author":"Boarini","year":"1985","journal-title":"Neurosurgery"},{"issue":"3-4","key":"10.1002\/14651858.CD007286.pub5-BIB0015|cit15","first-page":"207","article-title":"Early postoperative seizures and endovenous phenytoin. Preliminary clinical data","volume":"40","author":"De Santis","year":"1996","journal-title":"Journal of Neurosurgical Sciences"},{"issue":"2","key":"10.1002\/14651858.CD007286.pub5-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1528-1157.2002.24801.x","article-title":"Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: a randomized controlled study","volume":"43","author":"De Santis","year":"2002","journal-title":"Epilepsia"},{"issue":"6","key":"10.1002\/14651858.CD007286.pub5-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3171\/2009.6.JNS0928","article-title":"Preoperative antiepileptic drug administration and the incidence of postoperative seizures following bur hole-treated chronic subdural hematoma","volume":"111","author":"Grobelny","year":"2009","journal-title":"Journal of Neurosurgery"},{"issue":"12","key":"10.1002\/14651858.CD007286.pub5-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"828","DOI":"10.2176\/nmc.39.828","article-title":"Postoperative anticonvulsant prophylaxis for patients treated for cerebral aneurysms","volume":"39","author":"Hayashi","year":"1999","journal-title":"Neurologia Medico-Chirurgica"},{"issue":"3","key":"10.1002\/14651858.CD007286.pub5-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF01411737","article-title":"Peri-operative prophylaxis with phenytoin: dosage and therapeutic plasma levels","volume":"138","author":"Levati","year":"1996","journal-title":"Acta Neurochirurgica"},{"issue":"3","key":"10.1002\/14651858.CD007286.pub5-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11060-008-9781-4","article-title":"Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study","volume":"93","author":"Lim","year":"2009","journal-title":"Journal of Neuro-Oncology"},{"issue":"12","key":"10.1002\/14651858.CD007286.pub5-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2176\/nmc.43.589","article-title":"Postoperative seizures: epidemiology, pathology, and prophylaxis","volume":"43","author":"Manaka","year":"2003","journal-title":"Neurologia Medico-Chirurgica (Tokyo)"},{"issue":"9","key":"10.1002\/14651858.CD007286.pub5-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/BF02229161","article-title":"Phenobarbital in the prophylaxis of late posttraumatic seizures","volume":"13","author":"Murri","year":"1992","journal-title":"Italian Journal of Neurological Sciences"},{"issue":"3 Suppl","key":"10.1002\/14651858.CD007286.pub5-BIB0023|cit23","first-page":"269","article-title":"The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm","volume":"12","author":"Notani","year":"1984","journal-title":"No Shinkei Geka"},{"issue":"4","key":"10.1002\/14651858.CD007286.pub5-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/014107689108400412","article-title":"Epilepsy after craniotomy and the place of prophylactic anticonvulsant drugs: discussion paper","volume":"84","author":"Shaw","year":"1991","journal-title":"Journal of the Royal Society of Medicine"},{"issue":"8","key":"10.1002\/14651858.CD007286.pub5-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJM199008233230801","article-title":"A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures","volume":"323","author":"Temkin","year":"1990","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD007286.pub5-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3171\/jns.1999.91.4.0593","article-title":"Valproate therapy for prevention of posttraumatic seizures: a randomized trial","volume":"91","author":"Temkin","year":"1999","journal-title":"Journal of Neurosurgery"},{"issue":"1-2","key":"10.1002\/14651858.CD007286.pub5-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF01456348","article-title":"Phenytoin plasma levels after intraoperative administration, for the prevention of post-craniotomy seizures","volume":"84","author":"Tsolaki","year":"1987","journal-title":"Acta Neurochirurgica"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0028|cit28","unstructured":"Australian New Zealand Clinical Trials Registry Perampanel for the prevention of glioma associated seizures - efficacy and safety: a pilot phase II randomised controlled trial https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=371112&isReview=true"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0029|cit29","unstructured":"EU Clinical Trials Register Investigating the use of levetiracetam to prevent seizures after brain surgery. https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/trial\/2018-001312-30\/GB"},{"issue":"3","key":"10.1002\/14651858.CD007286.pub5-BIB0030|cit30","first-page":"38","article-title":"Surgical trial of prophylaxis for epilepsy in meningioma (STOP 'EM)","volume":"31","author":"Jenkinson","year":"2017","journal-title":"British Journal of Neurosurgery."},{"issue":"6","key":"10.1002\/14651858.CD007286.pub5-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/ana.10603","article-title":"Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia","volume":"53","author":"Calabresi","year":"2003","journal-title":"Annals of Neurology"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0032|cit32","unstructured":"Deeks JJ Higgins JP on behalf of the Cochrane Statistical Methods Group Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Churchill R, Chandler J, Cumpston MS (editors), Cochrane Handbook for Systematic Reviews of Interventions version 5.2.0 (updated June 2017), Cochrane, 2017 Available from www.training.cochrane.org\/handbook"},{"issue":"3-4","key":"10.1002\/14651858.CD007286.pub5-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF01808441","article-title":"The incidence of postoperative seizures","volume":"55","author":"Foy","year":"1981","journal-title":"Acta Neurochirurgica"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/bmj.328.7454.1490","article-title":"Grading quality of evidence and strength of recommendations","volume":"328","author":"GRADE Working Group","year":"2004","journal-title":"BMJ"},{"issue":"11","key":"10.1002\/14651858.CD007286.pub5-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0036|cit36","unstructured":"Higgins JP Altman DG Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Churchill R, Chandler J, Cumpston MS (editors), Cochrane Handbook for Systematic Reviews of Interventions version 5.2.0 (updated June 2017), Cochrane, 2017 Available from www.training.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jocn.2017.05.020","article-title":"The role of prophylactic antiepileptic drugs for seizure prophylaxis in meningioma surgery: a systematic review","volume":"43","author":"Islim","year":"2017","journal-title":"Journal of Clinical Neuroscience"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3171\/2017.10.JNS172236","article-title":"Effectiveness of perioperative antiepileptic drug prophylaxis for early and late seizures following oncologic neurosurgery: a meta-analysis","volume":"130","author":"Joiner","year":"2019","journal-title":"Journal of Neurosurgery"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1059-1311(96)80023-9","article-title":"Effectiveness of antiepileptic prophylaxis used with supratentorial craniotomies: a meta-analysis","volume":"5","author":"Kuijlen","year":"1996","journal-title":"Seizure"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0040|cit40","unstructured":"Lefebvre C Manheimer E Glanville J Chapter 6: Searching for studies. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"4","key":"10.1002\/14651858.CD007286.pub5-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1017\/S0317167100022757","article-title":"Seizures following intracranial surgery: incidence in the first post-operative week","volume":"7","author":"Matthew","year":"1980","journal-title":"Canadian Journal of Neurological Sciences"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0042|cit42","unstructured":"Higgins JP Lasserson T Chandler J Tovey D Churchill R Methodological Expectations of Cochrane Intervention Reviews Cochrane: London, Version 1.02 2016"},{"key":"10.1002\/14651858.CD007286.pub5-BIB0043|cit43","unstructured":"Sch\u00fcnemann HJ Oxman AD Higgins JP Vist GE Glasziou P Akl E on behalf of the Cochrane GRADEing Methods Group and the Cochrane Statistical Methods Group Chapter 11: Completing \u2018Summary of findings\u2019 tables and grading the confidence in or quality of the evidence. In: Higgins JPT, Churchill R, Chandler J, Cumpston MS (editors), Cochrane Handbook for Systematic Reviews of Interventions version 5.2.0 (updated June 2017). Cochrane, 2017 Available from www.training.cochrane.org\/handbook"},{"issue":"4","key":"10.1002\/14651858.CD007286.pub5-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1046\/j.1535-7597.2002.00038.x","article-title":"Prophylactic anticonvulsants after neurosurgery","volume":"2","author":"Temkin","year":"2002","journal-title":"Epilepsy Currents"},{"issue":"5","key":"10.1002\/14651858.CD007286.pub5-BIB0045|cit45","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007286.pub4","article-title":"Antiepileptic drugs as prophylaxis for postcraniotomy seizures","author":"Greenhalgh","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD007286.pub5-BIB0046|cit46","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007286.pub2","article-title":"Antiepileptic drugs as prophylaxis for post-craniotomy seizures","author":"Pulman","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD007286.pub5-BIB0047|cit47","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007286","article-title":"Antiepileptic drugs as prophylaxis for postcraniotomy seizures","author":"Vojvodic","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD007286.pub5-BIB0048|cit48","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007286.pub3","article-title":"Antiepileptic drugs as prophylaxis for post-craniotomy seizures","author":"Weston","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T18:08:51Z","timestamp":1628532531000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD007286.pub5"}},"subtitle":[],"editor":[{"name":"Cochrane Epilepsy Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":48,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007286.pub5","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,28]]}}}