{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:05:21Z","timestamp":1785942321813,"version":"3.56.0"},"update-to":[{"DOI":"10.1002\/14651858.cd007302","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000}}],"reference-count":33,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007302.pub2","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T13:16:19Z","timestamp":1359465379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vigabatrin for refractory partial epilepsy"],"prefix":"10.1002","author":[{"given":"Karla","family":"Hemming","sequence":"first","affiliation":[{"name":"University of Birmingham; Public Health, Epidemiology and Biostatistics; Edgbaston Birmingham UK B15 2TT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J","family":"Maguire","sequence":"additional","affiliation":[{"name":"Leeds General Infirmary; Neurology; Great George Street Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane L","family":"Hutton","sequence":"additional","affiliation":[{"name":"University of Warwick; Department of Statistics; Coventry UK CV4 7AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G","family":"Marson","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, University of Liverpool; Department of Molecular and Clinical Pharmacology; Clinical Sciences Centre for Research and Education, Lower Lane Fazakerley Liverpool Merseyside UK L9 7LJ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,31]]},"reference":[{"key":"10.1002\/14651858.CD007302.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1059-1311(96)80018-5","article-title":"A double-blind, placebo-controlled crossover study of vigabatrin 2 g\/day and 3 g\/day in uncontrolled partial seizures","volume":"5","author":"Beran","year":"1996","journal-title":"Seizure"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/seiz.2000.0381","article-title":"Vigabatrin as add-on therapy for adult complex partial seizures: a double-blind, placebo-controlled multicentre study. The Canadian Vigabatrin Study Group","volume":"9","author":"Bruni","year":"2000","journal-title":"Seizure"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1528-1157.1999.tb01991.x","article-title":"Dose-response study of vigabatrin as add-on therapy in patients with uncontrolled complex partial seizures","volume":"40","author":"Dean","year":"1999","journal-title":"Epilepsia"},{"issue":"2","key":"10.1002\/14651858.CD007302.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1528-1157.1995.tb00976.x","article-title":"Effects of differing dosages of vigabatrin (Sabril) on cognitive abilities and quality of life in epilepsy","volume":"36","author":"Dodrill","year":"1995","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1212\/WNL.43.12.2501","article-title":"Evaluation of the effects of vigabatrin on cognitive abilities and quality of life in epilepsy","volume":"43","author":"Dodrill","year":"1993","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1212\/WNL.46.1.54","article-title":"A double-blind, placebo-controlled study of vigabatrin three g\/day in patients with uncontrolled complex partial seizures","volume":"46","author":"French","year":"1996","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/ana.410170307","article-title":"Gamma-vinyl GABA: a double-blind placebo-controlled trial in partial epilepsy","volume":"17","author":"Gram","year":"1985","journal-title":"Annals of Neurology"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1136\/jnnp.57.9.1057","article-title":"Effects of vigabatrin on partial seizures and cognitive function","volume":"57","author":"Grunewald","year":"1994","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1528-1157.1986.tb03512.x","article-title":"Double blind, placebo controlled study of vigabatrin (gamma vinyl GABA) in drug resistant epilepsy","volume":"27","author":"Loiseau","year":"1986","journal-title":"Epilepsia"},{"issue":"5","key":"10.1002\/14651858.CD007302.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1528-1157.1993.tb02115.x","article-title":"Adjuvant vigabatrin in refractory epilepsy: a ceiling to effective dosage in individual patients?","volume":"34","author":"McKee","year":"1993","journal-title":"Epilepsia"},{"issue":"8370","key":"10.1002\/14651858.CD007302.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(84)92112-3","article-title":"Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy","volume":"1","author":"Rimmer","year":"1984","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1528-1157.1986.tb03600.x","article-title":"Vigabatrin in the treatment of epilepsy: a double blind, placebo controlled study","volume":"27","author":"Tartara","year":"1986","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1001\/archneur.1987.00520210009010","article-title":"Double blind study of vigabatrin in the treatment of drug resistant epilepsy","volume":"44","author":"Tassinari","year":"1987","journal-title":"Archives of Neurology"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0920-1211(96)00028-9","article-title":"Vigabatrin withdrawal randomised study in children","volume":"25","author":"Chiron","year":"1996","journal-title":"Epilepsy Research"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0015|cit15","first-page":"1271","article-title":"Effect of vigabatrin on sedation and cognitive function in patients with refractory epilepsy","volume":"56","author":"Gilham","year":"1993","journal-title":"Journal of Neurology"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-0404.1996.tb00032.x","article-title":"Influence of vigabatrin on cognitive performances and behaviour in patients with drug-resistant epilepsy","volume":"94","author":"Provinciali","year":"1996","journal-title":"Acta Neurologica Scandinavica"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1528-1157.1991.tb04688.x","article-title":"Open, double blind and long term study of vigabatrin in chronic epilepsy","volume":"32","author":"Reynolds","year":"1991","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/jnnp.53.12.1051","article-title":"Vigabatrin: rational treatment for chronic epilepsy","volume":"53","author":"Ring","year":"1990","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1528-1157.1999.tb00710.x","article-title":"Once-daily versus twice daily vigabatrin: is there a difference? The results of a double blind pilot study","volume":"40","author":"Zahner","year":"1999","journal-title":"Epilepsia"},{"issue":"10","key":"10.1002\/14651858.CD007302.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1528-1157.1998.tb01295.x","article-title":"Neuropsychological outcomes in randomised controlled trial of antiepileptic drugs. A systematic review of methodology and reporting standards","volume":"39","author":"Cochrane","year":"1998","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0140-6736(95)91208-8","article-title":"Remission of epilepsy: results from the national general practice study of epilepsy","volume":"346","author":"Cockerell","year":"1995","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD007302.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1528-1157.1989.tb05316.x","article-title":"Proposal for revised classification of epilepsies and epileptic syndromes","volume":"30","author":"Commission on Classification and Terminology of the International League Against Epilepsy","year":"1989","journal-title":"Epilepsia"},{"issue":"7075","key":"10.1002\/14651858.CD007302.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/bmj.314.7075.180","article-title":"Severe persistent visual field constriction associated with vigabatrin","volume":"314","author":"Eke","year":"1997","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD007302.pub2-BIB0024|cit24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001770.pub2","article-title":"Treatment of infantile spasms","author":"Hancock","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD007302.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1528-1157.1993.tb02586.x","article-title":"Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota:1935-984","volume":"34","author":"Hauser","year":"1993","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0026|cit26","unstructured":"Higgins JPT, Green S, editors. The Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005] In: The Cochrane Library, Issue 3. Chichester, UK: John Wiley and Sons Ltd., 2005"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0027|cit27","unstructured":"Lefebvre C Manheimer E Glanville J Chapter 6: Searching for studies. In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 (updated September 2009). The Cochrane Collaboration, 2009 Available from www.cochrane-handbook.org"},{"issue":"7066","key":"10.1002\/14651858.CD007302.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/bmj.313.7066.1169","article-title":"New antiepileptic drugs: a systematic review of their efficacy and tolerability","volume":"313","author":"Marson","year":"1996","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/jnnp.73.3.327","article-title":"The legacy of vigabatrin in a regional epilepsy clinic","volume":"73","author":"Nicolson","year":"2002","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0030|cit30","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2011"},{"issue":"5","key":"10.1002\/14651858.CD007302.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/jnnp.61.5.433","article-title":"Epidemiology of the epilepsies","volume":"61","author":"Sander","year":"1996","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/088307380502000101","article-title":"Treatment of pediatric epilepsy: expert opinion","volume":"20 Suppl","author":"Wheless","year":"2005","journal-title":"Journal of Child Neurology"},{"key":"10.1002\/14651858.CD007302.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/j.1528-1167.2007.01133.x","article-title":"Vigabatrin and epilepsy: lessons learned","volume":"48","author":"Wild","year":"2007","journal-title":"Epilepsia"}],"updated-by":[{"DOI":"10.1002\/14651858.cd007302.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD007302.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T22:09:00Z","timestamp":1628546940000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD007302.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Epilepsy Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,31]]},"references-count":33,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007302.pub2","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD007302.pub3","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,31]]}}}