{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:44:52Z","timestamp":1790289892201,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd007354.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000}}],"reference-count":140,"publisher":"Wiley","issue":"10","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007354.pub3","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T14:26:58Z","timestamp":1476973618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults"],"prefix":"10.1002","volume":"2016","author":[{"given":"Steffen T","family":"Simon","sequence":"first","affiliation":[{"name":"Institute of Palliative Care (ipac); J\u00e4gerstr. 64-66 Oldenburg Germany 26121"},{"name":"University Hospital of Cologne; Department of Palliative Medicine; Cologne Germany"},{"name":"King's College London; Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene J","family":"Higginson","sequence":"additional","affiliation":[{"name":"King's College London; Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Booth","sequence":"additional","affiliation":[{"name":"Cambridge University Hospitals; Department of Palliative Care; Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Harding","sequence":"additional","affiliation":[{"name":"King's College London; Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Weing\u00e4rtner","sequence":"additional","affiliation":[{"name":"University Hospital of Cologne; Department of Palliative Medicine; Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bausewein","sequence":"additional","affiliation":[{"name":"LMU Munich; Department of Palliative Medicine, Munich University Hospital; Marchioninistr. 15 Munich Germany 81377"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"10.1002\/14651858.CD007354.pub3-BIB0001|cit1","first-page":"359","article-title":"Effects of clorazepate on breathlessness and exercise tolerance in patients with chronic airflow obstruction","volume":"21","author":"Eimer","year":"1985","journal-title":"Journal of Family Practice"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0002|cit2","unstructured":"Harrison TJR A comparison of the effectiveness of oral lorazepam and placebo in relieving breathlessness associated with advanced cancer (MSc thesis, 2004)"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1378\/chest.90.6.832","article-title":"Effect of alprazolam on exercise and dyspnea in patients with chronic obstructive pulmonary disease","volume":"90","author":"Man","year":"1986","journal-title":"Chest"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpainsymman.2005.06.009","article-title":"Midazolam as adjunct therapy to morphine in the alleviation of severe dyspnea perception in patients with advanced cancer","volume":"31","author":"Navigante","year":"2006","journal-title":"Journal of Pain and Symptom Management"},{"issue":"5","key":"10.1002\/14651858.CD007354.pub3-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jpainsymman.2009.10.003","article-title":"Morphine versus midazolam as upfront therapy to control dyspnea perception in cancer patients while its underlying cause is sought or treated","volume":"39","author":"Navigante","year":"2010","journal-title":"Journal of Pain and Symptom Management"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0006|cit6","first-page":"196","article-title":"Effects of alprazolam on gas exchange, breathing pattern, and lung function in COPD patients with anxiety","volume":"34","author":"Shivaram","year":"1989","journal-title":"Respiratory Care"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.rmed.2009.10.022","article-title":"Temazepam 10 mg does not affect breathing and gas exchange in patients with severe normocapnic COPD","volume":"104","author":"Stege","year":"2010","journal-title":"Respiratory Medicine"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/bmj.283.6287.343","article-title":"Drug treatment of breathlessness: contrasting effects of diazepam and promethazine in pink puffers","volume":"283","author":"Woodcock","year":"1981","journal-title":"British Medical Journal"},{"issue":"7","key":"10.1002\/14651858.CD007354.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/jpm.2012.0505","article-title":"The role of benzodiazepines in breathlessness: a single site, open label pilot of sustained release morphine together with clonazepam","volume":"16","author":"Allcroft","year":"2013","journal-title":"Journal of Palliative Medicine"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0010|cit10","first-page":"397","article-title":"Treatment of dyspnoea: the role of drugs","volume":"8","author":"Allen","year":"1984","journal-title":"Drugs of Today"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0011|cit11","first-page":"242","article-title":"Diazepam and breathlessness","volume":"2","author":"Anonymous","year":"1980","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1136\/bmj.281.6250.1232-a","article-title":"Centrally acting drugs in chronic airways obstruction","volume":"281","author":"Anonymous (British Medical Journal)","year":"1980","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0140-6736(89)91775-3","article-title":"Efficacy of flumazenil in COPD patient with therapeutic diazepam levels","volume":"1","author":"Appel","year":"1989","journal-title":"The Lancet"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000196202","article-title":"Buspirone effect on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease","volume":"60","author":"Argyropoulou","year":"1993","journal-title":"Respiration"},{"issue":"22","key":"10.1002\/14651858.CD007354.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJM198206033062214","article-title":"Breathlessness, alcohol, and opiates","volume":"306","author":"Bar-Or","year":"1982","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000195530","article-title":"Respiratory center output following zopiclone or diazepam administration in patients with pulmonary disease","volume":"54","author":"Beaupre","year":"1988","journal-title":"Respiration"},{"issue":"2","key":"10.1002\/14651858.CD007354.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0033-3182(92)71995-1","article-title":"Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease","volume":"33","author":"Borson","year":"1992","journal-title":"Psychosomatics"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0885-3924(90)90020-K","article-title":"Subcutaneous midazolam infusion in palliative care","volume":"5","author":"Bottomley","year":"1990","journal-title":"Journal of Pain and Symptom Management"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0019|cit19","doi-asserted-by":"crossref","unstructured":"Boyden JY Connor SR Otolorin L Nathan SD Fine PG Davis MS Nebulized medications for the treatment of dyspnea: A literature review Journal of Aerosol Medicine and Pulmonary Drug Delivery 2015 1 19","DOI":"10.1089\/jamp.2014.1136"},{"issue":"1","key":"10.1002\/14651858.CD007354.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000542-197101000-00005","article-title":"The effects of diazepam on the ventilatory response to carbon dioxide and on steady-state gas exchange","volume":"34","author":"Catchlove","year":"1971","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1002\/14651858.CD007354.pub3-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/00000542-197101000-00006","article-title":"The effects of diazepam on respiration in patients with obstructive pulmonary disease","volume":"34","author":"Catchlove","year":"1971","journal-title":"Anesthesiology"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0022|cit22","doi-asserted-by":"crossref","unstructured":"Cherny NI ESMO clinical practice guidelines for the management of refractory symptoms at the end of life and the use of palliative sedation Annals of Oncology 2014 iii143 52","DOI":"10.1093\/annonc\/mdu238"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0140-6736(71)92105-2","article-title":"Respiratory depression caused by nitrazepam in patients with respiratory failure","volume":"2","author":"Clark","year":"1971","journal-title":"The Lancet"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0024|cit24","doi-asserted-by":"crossref","unstructured":"Clemens KE Klaschik E Dyspnoea associated with anxiety - symptomatic therapy with opioids in combination with lorazepam and its effect on ventilation in palliative care patients Supportive Care in Cancer 2011 2027 33","DOI":"10.1007\/s00520-010-1058-8"},{"issue":"2","key":"10.1002\/14651858.CD007354.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2165\/00002018-199207020-00006","article-title":"Effects of estazolam and flurazepam on cardiopulmonary function in patients with chronic obstructive pulmonary disease","volume":"7","author":"Cohn","year":"1992","journal-title":"Drug Safety"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0026|cit26","unstructured":"Daubert E Bolesta S Effect of lorazepam versus morphine on quality of life in hospice patients with dyspnea and anxiety Journal of the American Pharmacists Association 2014 e193"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1185\/03007997409111871","article-title":"Double-blind comparison of the respiratory effects of parenteral lorazepam and diazepam in patients with chronic obstructive lung disease","volume":"2","author":"Denaut","year":"1974","journal-title":"Current Medical Research and Opinion"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0140-6736(88)91057-4","article-title":"Midazolam in terminal care","volume":"331","author":"Sousa","year":"1988","journal-title":"The Lancet"},{"issue":"2","key":"10.1002\/14651858.CD007354.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0002-9343(82)90185-1","article-title":"Effect of flurazepam on sleep-disordered breathing and nocturnal oxygen desaturation in asymptomatic subjects","volume":"73","author":"Dolly","year":"1982","journal-title":"American Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1191\/1479972304cd032rs","article-title":"Anxiety and self-management behaviour in chronic obstructive pulmonary disease: what has been learned?","volume":"1","author":"Dowson","year":"2004","journal-title":"Chronic Respiratory Disease"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0031|cit31","doi-asserted-by":"crossref","unstructured":"Ekstrom MP Abernethy AP Currow DC The management of chronic breathlessness in patients with advanced and terminal illness BMJ (Online) 2015","DOI":"10.1136\/bmj.g7617"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0032|cit32","unstructured":"Fonsmark L Hein L Nibroe H Bundgaard H De Haas I Iversen S Danish national sedation strategy. Targeted therapy of discomfort associated with critical illness. Danish Society of Intensive Care Medicine (DSIT) and the Danish Society of Anesthesiology and Intensive Care Medicine (DASAIM) Danish Medical Journal 2015 1 5"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1213\/00000539-198310000-00012","article-title":"Respiratory depressant effects of different doses of midazolam and lack of reversal with naloxone: a double-blind randomized study","volume":"62","author":"Forster","year":"1983","journal-title":"Anesthesia Analgesia"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1136\/bmj.2.5815.688","article-title":"Effect of nitrazepam in chronic obstructive bronchitis","volume":"2","author":"Gaddie","year":"1972","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0035|cit35","unstructured":"Garrett Key R Psychiatric care of lung cancer patients Oncology 2015"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/thx.31.5.548","article-title":"Effect of nitrazepam and flurazepam on the ventilatory response to carbon dioxide","volume":"31","author":"Geddes","year":"1976","journal-title":"Thorax"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0037|cit37","doi-asserted-by":"crossref","unstructured":"Gomutbutra P O'Riordan DL Pantilat SZ Management of moderate-to-severe dyspnea in hospitalized patients receiving palliative care Journal of Pain and Symptom Management 2013 885 91","DOI":"10.1016\/j.jpainsymman.2012.05.004"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/j.1875-9114.1989.tb04101.x","article-title":"Effects of alprazolam on respiratory drive, anxiety, and dyspnea in chronic airflow obstruction: a case study","volume":"9","author":"Greene","year":"1989","journal-title":"Pharmacotherapy"},{"issue":"6","key":"10.1002\/14651858.CD007354.pub3-BIB0039|cit39","first-page":"524","article-title":"Cardiac failure and benzodiazepines","volume":"16","author":"Guilleminault","year":"1993","journal-title":"Sleep"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0040|cit40","first-page":"209","article-title":"Quantifying dyspnoea and the use of drugs to alleviate the symptom","volume":"16","author":"Guz","year":"1980","journal-title":"Clinical Respiratory Physiology"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2044.1972.tb08158.x","article-title":"The effect of diazepam on airway resistance in asthmatics","volume":"27","author":"Heinonen","year":"1972","journal-title":"Anaesthesia"},{"issue":"11","key":"10.1002\/14651858.CD007354.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1183\/09031936.94.07112011","article-title":"Nitrazepam in patients with sleep apnoea: a double-blind placebo-controlled study","volume":"7","author":"Hoeijer","year":"1994","journal-title":"European Respiratory Journal"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0043|cit43","first-page":"275","article-title":"Symptom control and ethics in final stages of COPD","volume":"156","author":"Horfarter","year":"2006","journal-title":"Wiener Medizinische Wochenschrift"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0044|cit44","first-page":"522","article-title":"Effects of diazepam on quality of life in patients receiving home oxygen therapy: a double-blind, cross-over, placebo-controlled clinical trial [Japanese]","volume":"5","author":"Hosaka","year":"1996","journal-title":"Journal of the Showa Medical Association"},{"issue":"10","key":"10.1002\/14651858.CD007354.pub3-BIB0045|cit45","first-page":"1594","article-title":"The influence of laevomepromazine and prometazine on respiration in healthy subjects and patients with pulmonary emphysema","volume":"21","author":"Huttemann","year":"1971","journal-title":"Arzneimittelforschung"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/104990919301000105","article-title":"Midazolam in terminal care","volume":"10","author":"Johanson","year":"1993","journal-title":"American Journal of Hospice and Palliative Care"},{"issue":"9","key":"10.1002\/14651858.CD007354.pub3-BIB0047|cit47","first-page":"573","article-title":"Flupenthixol versus diazepam in the treatment of psychosomatic disorders: a double-blind, multi-centre trial in general practice","volume":"3","author":"Jokinen","year":"1984","journal-title":"Pharmatherapeutica"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0048|cit48","first-page":"472","article-title":"Acute effect of lorazepam on respiratory muscles in stable patients with chronic obstructive pulmonary disease","volume":"56","author":"Jolly","year":"1996","journal-title":"Medicina (B Aires)"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1042\/cs069006P","article-title":"The effect of promethazine and diazepam on respiratory control in breathless patients (abstract)","volume":"69","author":"Jones","year":"1985","journal-title":"Clinical Science"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0050|cit50","unstructured":"Kaltsas K Anevlavis S Bouros D Safety of opioids and benzodiazepines in patients with breathlessness and respiratory failure associated with chronic obstructive pulmonary disease Pneumon 2014 197 9"},{"issue":"45","key":"10.1002\/14651858.CD007354.pub3-BIB0051|cit51","first-page":"1814","article-title":"On the therapy of asthmatic dyspnea","volume":"63","author":"Kann","year":"1968","journal-title":"Medizinische Klinik"},{"issue":"1","key":"10.1002\/14651858.CD007354.pub3-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.7326\/0003-4819-83-1-83","article-title":"The use of oral diazepam in patients with obstructive lung disease and hypercapnia","volume":"83","author":"Kronenberg","year":"1975","journal-title":"Annals of Internal Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007354.pub3-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/cpt1976202178","article-title":"Effect of diazepam on ventilatory responses","volume":"20","author":"Lakshminarayan","year":"1976","journal-title":"Clinical Pharmacology and Therapeutics"},{"issue":"1","key":"10.1002\/14651858.CD007354.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0147-9563(99)70044-0","article-title":"Dyspnea in patients with chronic obstructive pulmonary disease: does dyspnea worsen longitudinally in the presence of declining lung function?","volume":"28","author":"Lareau","year":"1999","journal-title":"Heart & Lung"},{"issue":"6","key":"10.1002\/14651858.CD007354.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1159\/000194517","article-title":"Relief of breathlessness in a case of progressive pulmonary fibrosis","volume":"43","author":"Laros","year":"1982","journal-title":"Respiration"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0056|cit56","first-page":"1318","article-title":"Controlled therapeutic comparison of antiasthmatics in out-patients in a double-blind experiment","volume":"17","author":"Lichterfeld","year":"1967","journal-title":"Arzneimittel-Forschung"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1378\/chest.109.4.975","article-title":"Effect of 30 mg of morphine alone or with promethazine or prochlorperazine on the exercise capacity of patients with COPD","volume":"109","author":"Light","year":"1996","journal-title":"Chest"},{"issue":"2","key":"10.1002\/14651858.CD007354.pub3-BIB0058|cit58","first-page":"90","article-title":"Bronchopulmonary carcinoma: a medical approach to the last weeks of life; a study of 191 cases","volume":"138","author":"Marin","year":"1987","journal-title":"Annales de Medecine Interne"},{"issue":"5","key":"10.1002\/14651858.CD007354.pub3-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0885-3924(94)90193-7","article-title":"The use of chlorpromazine for symptom control in dying cancer patients","volume":"9","author":"McIver","year":"1994","journal-title":"Journal of Pain and Symptom Management"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0060|cit60","first-page":"9","article-title":"Diazepam in the treatment of dyspnoea in the 'Pink Puffer' syndrome","volume":"49","author":"Mitchell-Heggs","year":"1980","journal-title":"Quarterly Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0061|cit61","first-page":"418","article-title":"Dyspnoea in 'pink puffers': the place of diazepam","volume":"74","author":"Mitchell-Heggs","year":"1980","journal-title":"British Journal of Diseases of the Chest"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0062|cit62","doi-asserted-by":"crossref","unstructured":"Mouzi L Ashutosh W Anesthetic management during labor and delivery of a multiparous patient terminally ill with metastatic breast cancer A&A Case Reports 2014 48 9","DOI":"10.1097\/ACC.0b013e3182a999fa"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"51S","DOI":"10.1378\/chest.97.3_Supplement.51S","article-title":"Comparison of zolpidem (Z), triazolam (T), and flunitrazepam (F) effects on arterial blood gases and control of breathing in patients with severe chronic obstructive pulmonary disease (COPD) (abstract)","volume":"97","author":"Murciano","year":"1990","journal-title":"Chest"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1183\/09031936.93.06050625","article-title":"Acute effects of zolpidem, triazolam and flunitrazepam on arterial blood gases and control of breathing in severe COPD","volume":"6","author":"Murciano","year":"1993","journal-title":"European Respiratory Journal"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0065|cit65","first-page":"474","article-title":"Compared and randomized prospective trial between oxygenotherapy vs. morphine chlorhydrate + midazolam by subcutaneous route in patients with advanced cancer and dyspnea","volume":"84","author":"Navigante","year":"1997","journal-title":"Prensa Medica Argentina"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0066|cit66","first-page":"14","article-title":"Morphine plus midazolam versus oxygen therapy on severe dyspnea management in the last week of life in hipoxemic advanced cancer patients","volume":"10","author":"Navigante","year":"2003","journal-title":"Medicina Paliativa"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0067|cit67","unstructured":"NCT01687751 Pilot study comparing treatment with dexmedetomidine to midazolam for symptom control in advanced cancer patients clinicaltrials.gov\/show\/NCT01687751"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0736-4679(97)00022-X","article-title":"Midazolam: a review of therapeutic uses and toxicity","volume":"15","author":"Nordt","year":"1997","journal-title":"Journal of Emergency Medicine"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1378\/chest.102.3.824","article-title":"Breathlessness in patients with severe chronic airflow limitation. Physiologic correlations","volume":"102","author":"O'Donnell","year":"1992","journal-title":"Chest"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1378\/chest.106.3.904","article-title":"Breathlessness in patients with chronic airflow limitation. Mechanisms and management","volume":"106","author":"O'Donnell","year":"1994","journal-title":"Chest"},{"issue":"6","key":"10.1002\/14651858.CD007354.pub3-BIB0071|cit71","first-page":"544","article-title":"Dyspnea in advanced chronic obstructive pulmonary disease","volume":"17","author":"O'Donnell","year":"1998","journal-title":"Journal of Heart & Lung Transplantation"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1365-2125.1985.tb02716.x","article-title":"Chlorpromazine - a specific effect on breathlessness?","volume":"19","author":"O'Neill","year":"1985","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"2","key":"10.1002\/14651858.CD007354.pub3-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/cpt1973142182","article-title":"Cardiopulmonary effects of diazepam","volume":"14","author":"Rao","year":"1973","journal-title":"Clinical Pharmacology & Therapeutics"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/clpt.1991.46","article-title":"Differing effects of the anxiolytic agents buspirone and diazepam on control of breathing","volume":"49","author":"Rapoport","year":"1991","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1378\/chest.90.6.789","article-title":"Treatment of dyspnea with psychotropic agents","volume":"90","author":"Rice","year":"1986","journal-title":"Chest"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0007-0971(87)90163-X","article-title":"Effects of chronic administration of codeine and promethazine on breathlessness and exercise tolerance in patients with chronic airflow obstruction","volume":"81","author":"Rice","year":"1987","journal-title":"British Journal of Disease of the Chest"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0077|cit77","doi-asserted-by":"crossref","unstructured":"Rodriguez-Roisin R Garcia-Aymerich J Should we exercise caution with benzodiazepine use in patients with COPD? European Respiratory Journal 2014 284 6","DOI":"10.1183\/09031936.00071014"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0738-3991(02)00004-6","article-title":"The most effective psychologically-based treatments to reduce anxiety and panic in patients with chronic obstructive pulmonary disease (COPD): a systematic review","volume":"47","author":"Rose","year":"2002","journal-title":"Patient Education Counseling"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/thx.33.1.97","article-title":"Depression of central respiratory drive by nitrazepam","volume":"33","author":"Rudolf","year":"1978","journal-title":"Thorax"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/ewjm.175.3.197","article-title":"Treating dyspnea in a patient with advanced chronic obstructive pulmonary disease","volume":"175","author":"Runo","year":"2001","journal-title":"Western Journal of Medicine"},{"issue":"6","key":"10.1002\/14651858.CD007354.pub3-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1055\/s-2007-959252","article-title":"The critically ill patient with COPD","volume":"61","author":"Schultze-Werninghaus","year":"2007","journal-title":"Pneumologie"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0082|cit82","first-page":"232","article-title":"The response of the breathless patient treated with diazepam","volume":"37","author":"Sen","year":"1983","journal-title":"British Journal of Clinical Practice"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1378\/chest.103.3.800","article-title":"Effects of buspirone on anxiety levels and exercise tolerance in patients with chronic airflow obstruction and mild anxiety","volume":"103","author":"Singh","year":"1993","journal-title":"Chest"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0084|cit84","doi-asserted-by":"crossref","unstructured":"Smith TJ Symptom management in the older adult. 2015 Update Clinics in Geriatric Medicine 2015 155 75","DOI":"10.1016\/j.cger.2015.01.006"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0085|cit85","first-page":"600","article-title":"Does diazepam reduce breathlessness in healthy subjects? (abstract)","volume":"13","author":"Stark","year":"1982","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1042\/cs0610429","article-title":"Methods to assess breathlessness in healthy subjects: a critical evaluation and application to analyse the acute effects of diazepam and promethazine on breathlessness induced by exercise or by exposure to raised levels of carbon dioxide","volume":"61","author":"Stark","year":"1981","journal-title":"Clinical Science"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1136\/bmj.286.6373.1280-c","article-title":"Dihydrocodeine for breathlessness in pink puffers","volume":"286","author":"Stark","year":"1983","journal-title":"British Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1183\/09031936.93.01030280","article-title":"Dyspnoea: Assessment and pharmacological manipulation","volume":"1","author":"Stark","year":"1988","journal-title":"European Respiratory Journal"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/sleep\/16.4.318","article-title":"Effects of zolpidem and triazolam on sleep and respiration in mild to moderate chronic obstructive pulmonary disease","volume":"16","author":"Steens","year":"1993","journal-title":"Sleep"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0090|cit90","doi-asserted-by":"crossref","unstructured":"Tenorio Carmona B Ramirez Rodriguez G Rangel Selvera OA Ales Siles I Sanchez Del Corral Usaola F Ruiperez Cantera I Associated symptoms to terminality in elderly patient and the necessity of subcutaneous application at the home care assistance European Geriatric Medicine 2012 S47","DOI":"10.1016\/j.eurger.2012.07.046"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1001\/archinte.1988.00380100049011","article-title":"Effect of triazolam on sleep and arterial oxygen saturation in patients with chronic obstructive pulmonary disease","volume":"148","author":"Timms","year":"1988","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0092|cit92","doi-asserted-by":"crossref","unstructured":"Vozoris NT Fischer HD Wang X Anderson GM Bell CM Gershon AS Benzodiazepine use among older adults with chronic obstructive pulmonary disease: a population-based cohort study Drugs & Aging 2013 183 92","DOI":"10.1007\/s40266-013-0056-1"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0140-6736(93)91588-D","article-title":"Dyspnoea in advanced cancer","volume":"342","author":"Walsh","year":"1993","journal-title":"The Lancet"},{"issue":"5","key":"10.1002\/14651858.CD007354.pub3-BIB0094|cit94","first-page":"239","article-title":"Dyspnea relief in the palliative phase","volume":"48","author":"Wanrooij","year":"2005","journal-title":"Huisarts en Wetenschap"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0095|cit95","first-page":"588","article-title":"The effect of sedation on pulmonary function","volume":"44","author":"Wiedemann","year":"1995","journal-title":"Anaesthetist"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0002-9343(54)90121-7","article-title":"Respiratory acidosis. I. Effects of decreasing respiratory minute volume in patients with severe chronic pulmonary emphysema, with specific reference to oxygen, morphine and barbiturates","volume":"17","author":"Wilson","year":"1954","journal-title":"American Journal of Medicine"},{"issue":"27","key":"10.1002\/14651858.CD007354.pub3-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1056\/NEJM198112313052703","article-title":"Effects of dihydrocodeine, alcohol, and caffeine on breathlessness and exercise tolerance in patients with chronic obstructive lung disease and normal blood gases","volume":"305","author":"Woodcock","year":"1981","journal-title":"The New England Journal of Medicine"},{"issue":"8226","key":"10.1002\/14651858.CD007354.pub3-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(81)91612-3","article-title":"Oxygen relieves breathlessness in \"pink puffers\"","volume":"317","author":"Woodcock","year":"1981","journal-title":"The Lancet"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0099|cit99","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1007\/s00520-016-3125-2","article-title":"A randomised, double-blind controlled trial of intranasal midazolam for the palliation of dyspnoea in patients with life-limiting disease","volume":"24","author":"Hardy","year":"2016","journal-title":"Support Care Cancer"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0100|cit100","first-page":"A2953","article-title":"Randomised control trial of intranasal midazolam or oral lorazepam for the relief of dyspnoea in severe respiratory disease [Abstract]","volume":"185","author":"Hart","year":"2012","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"1","key":"10.1002\/14651858.CD007354.pub3-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1179\/096992608X291243","article-title":"Pharmacological management of breathlessness in advanced disease","volume":"16","author":"Abernethy","year":"2008","journal-title":"Progress in Palliative Care"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"77S","DOI":"10.1378\/chest.88.2_Supplement.77S","article-title":"Assessment and management of breathlessness","volume":"88","author":"Altose","year":"1985","journal-title":"Chest"},{"issue":"2","key":"10.1002\/14651858.CD007354.pub3-BIB0103|cit103","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005623.pub2","article-title":"Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases","author":"Bausewein","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0104|cit104","first-page":"1","article-title":"The genesis of breathlessness - what do we understand?","volume-title":"Dyspnoea in Advanced Disease - a Guide to Clinical Management","author":"Beach","year":"2006"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0105|cit105","volume-title":"Dyspnoea in Advanced Disease - a Guide to Clinical Management","author":"Booth","year":"2006"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/ncponc1034","article-title":"The etiology and management of intractable breathlessness in patients with advanced cancer: a systematic review of pharmacological therapy","volume":"5","author":"Booth","year":"2008","journal-title":"Nature Clinical Practice Oncology"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0107|cit107","volume-title":"Textbook of Palliative Medicine","author":"Bruera","year":"2006"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0108|cit108","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004769.pub2","article-title":"Oxygen therapy for dyspnoea in adults","author":"Cranston","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jpainsymman.2009.09.017","article-title":"Do the trajectories of dyspnea differ in prevalence and intensity by diagnosis at the end of life? A consecutive cohort study","volume":"39","author":"Currow","year":"2010","journal-title":"Journal of Pain and Symptom Management"},{"issue":"7113","key":"10.1002\/14651858.CD007354.pub3-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1136\/bmj.315.7113.931","article-title":"ABC of palliative care","volume":"315","author":"Davis","year":"1997","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0111|cit111","first-page":"147","article-title":"Drug therapies","volume-title":"Supportive Care in Respiratory Disease","author":"Davis","year":"2005"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/026921639100500309","article-title":"Does pharmacological treatment affect the sensation of breathlessness in terminal cancer patients?","volume":"5","author":"Conno","year":"1991","journal-title":"Palliative Medicine"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0269216309102520","article-title":"Researching breathlessness in palliative care: consensus statement of the National Cancer Research Institute Palliative Care Breathlessness Subgroup","volume":"23","author":"Dorman","year":"2009","journal-title":"Palliative Medicine"},{"issue":"1","key":"10.1002\/14651858.CD007354.pub3-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/10810730150501413","article-title":"Presenting risk information - a review of the effects of \"framing\" and other manipulations on patient outcomes","volume":"6","author":"Edwards","year":"2001","journal-title":"Journal of Health Communication"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0115|cit115","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001865.pub2","article-title":"Personalised risk communication for informed decision making about entering screening programs","author":"Edwards","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"g445","DOI":"10.1136\/bmj.g445","article-title":"Safety of benzodiazepines and opioids in very severe respiratory disease: national prospective study","volume":"348","author":"Ekstrom","year":"2014","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0118|cit118","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD) Global strategy for the diagnosis, management and prevention of COPD (2007) http:\/\/www.goldcopd.org"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0119|cit119","volume-title":"Goodman & Gilman's The Pharmacological Basis of Therapeutics","author":"Hardman","year":"2005"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0120|cit120","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions, The Cochrane Collaboration Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0121|cit121","first-page":"14","article-title":"The epidemiology of death and symptoms","volume-title":"Oxford Textbook of Palliative Medicine","author":"Higginson","year":"2004"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0122|cit122","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002066","article-title":"Opioids for the palliation of breathlessness in terminal illness","author":"Jennings","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD007354.pub3-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200605-587ST","article-title":"An official American Thoracic Society clinical policy statement: palliative care for patients with respiratory diseases and critical illnesses","volume":"177","author":"Lanken","year":"2008","journal-title":"Journal of Respiratory and Critical Care Medicine"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJM199512073332307","article-title":"Pathophysiology of dyspnea","volume":"333","author":"Manning","year":"1995","journal-title":"The New England Journal of Medicine"},{"issue":"11","key":"10.1002\/14651858.CD007354.pub3-BIB0125|cit125","first-page":"1342","article-title":"Dyspnea treatment","volume":"45","author":"Manning","year":"2000","journal-title":"Respiratory Care"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0126|cit126","doi-asserted-by":"crossref","unstructured":"Moens K Higginson IJ Harding R Are there differences in the prevalence of palliative care-related problems in people living with advanced cancer and eight non-cancer conditions? A systematic review Journal of Pain and Symptom Management 2014 660 77","DOI":"10.1016\/j.jpainsymman.2013.11.009"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0127|cit127","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.rmed.2006.01.016","article-title":"Dyspnea in relation to symptoms of anxiety and depression: a prospective population study","volume":"100","author":"Neuman","year":"2006","journal-title":"Respiratory Medicine"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0128|cit128","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1474-5151(03)00059-8","article-title":"Symptoms experienced in the last six months of life in patients with end-stage heart failure","volume":"2","author":"Nordgren","year":"2003","journal-title":"European Journal of Cardiovascular Nursing"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1164\/rccm.201111-2042ST","article-title":"An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea","volume":"185","author":"Parshall","year":"2012","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0130|cit130","unstructured":"The Nordic Cochrane Centre. The Cochrane Collaboration Review Manager (RevMan) 2008"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0131|cit131","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0132|cit132","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s005200050255","article-title":"Management of dyspnea in advanced cancer patients","volume":"7","author":"Ripamonti","year":"1999","journal-title":"Supportive Care in Cancer"},{"issue":"3","key":"10.1002\/14651858.CD007354.pub3-BIB0133|cit133","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/jpm.2007.9951","article-title":"Advanced chronic obstructive pulmonary disease: innovative approaches to palliation","volume":"10","author":"Rocker","year":"2007","journal-title":"Journal of Palliative Medicine"},{"issue":"9","key":"10.1002\/14651858.CD007354.pub3-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1200\/JCO.2010.30.7173","article-title":"Trajectory of performance status and symptom scores for patients with cancer during the last six months of life","volume":"29","author":"Seow","year":"2011","journal-title":"Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology"},{"issue":"6","key":"10.1002\/14651858.CD007354.pub3-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jpainsymman.2012.06.008","article-title":"Episodic and continuous breathlessness: a new categorization of breathlessness","volume":"45","author":"Simon","year":"2012","journal-title":"Journal of Pain and Symptom Management"},{"issue":"5","key":"10.1002\/14651858.CD007354.pub3-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jpainsymman.2013.06.013","article-title":"Definition, categorization, and terminology of episodic breathlessness: consensus by an International Delphi Survey","volume":"47","author":"Simon","year":"2014","journal-title":"Journal of Pain and Symptom Management"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1470-2045(02)00713-1","article-title":"Clinical management of dyspnoea","volume":"3","author":"Thomas","year":"2002","journal-title":"The Lancet Oncology"},{"key":"10.1002\/14651858.CD007354.pub3-BIB0138|cit138","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1001\/archinte.1990.00040031604007","article-title":"Dyspnoea","volume":"150","author":"Tobin","year":"1990","journal-title":"Archives of Internal Medicine"},{"issue":"4","key":"10.1002\/14651858.CD007354.pub3-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00520-007-0389-6","article-title":"The management of dyspnea in cancer patients: a systematic review","volume":"16","author":"Viola","year":"2008","journal-title":"Supportive Care Cancer"},{"issue":"5","key":"10.1002\/14651858.CD007354.pub3-BIB0140|cit140","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00130404-200609000-00006","article-title":"Dyspnea","volume":"12","author":"Williams","year":"2006","journal-title":"Cancer Journal"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD007354.pub3\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T04:18:03Z","timestamp":1717733883000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007354.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Pain, Palliative and Supportive Care Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":140,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007354.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]}}}