{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:08:09Z","timestamp":1790788089928,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd007451","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000}}],"reference-count":87,"publisher":"Wiley","issue":"4","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007451.pub2","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T09:26:18Z","timestamp":1457601978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension"],"prefix":"10.1002","volume":"2016","author":[{"given":"Gavin WK","family":"Wong","sequence":"first","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Sciences Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi N","family":"Boyda","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Sciences Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Wright","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Sciences Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"issue":"5","key":"10.1002\/14651858.CD007451.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0002-9149(90)90486-K","article-title":"Cardiac and skeletal muscle adaptations to training in systemic hypertension and effect of beta blockade (metoprolol or propranolol)","volume":"66","author":"Ades","year":"1990","journal-title":"American Journal of Cardiology"},{"issue":"5","key":"10.1002\/14651858.CD007451.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1097\/00005344-199111000-00014","article-title":"Impact of diagnosis and treatment of hypertension on quality of life: a double-blind, randomized, placebo-controlled, cross-over study of betaxolol","volume":"18","author":"Ameling","year":"1991","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0002-9149(91)90711-S","article-title":"Effect of bisoprolol on blood pressure and arterial hemodynamics in systemic hypertension","volume":"68","author":"Asmar","year":"1991","journal-title":"American Journal of Cardiology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007451.pub2-BIB0004|cit4","first-page":"63s","article-title":"Antihypertensive effect of doxazosin in hypertensive patients: comparison with atenolol","volume":"21","author":"Baez","year":"1986","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2125.1979.tb00946.x","article-title":"Atenolol and chlorthalidone in combination for hypertension","volume":"7","author":"Bateman","year":"1979","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"1-2","key":"10.1002\/14651858.CD007451.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.0954-6820.1976.tb06692.x","article-title":"The effect of metoprolol - a new selective adrenergic beta1-receptor blocking agent-- in mild hypertension","volume":"199","author":"Bengtsson","year":"1976","journal-title":"Acta Medica Scandinavica"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/01.HYP.7.5.688","article-title":"Monitoring 24-hour blood pressure in a drug trial. Evaluation of a noninvasive device","volume":"7","author":"Berglund","year":"1985","journal-title":"Hypertension"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/00926239208412857","article-title":"Bisoprolol and hypertension: effects on sexual functioning in men","volume":"18","author":"Broekman","year":"1992","journal-title":"Journal of Sex & Marital Therapy"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/BF03258271","article-title":"Effects of nebivolol on blood pressure, hormones and cardiac function in Chinese subjects with essential hypertension","volume":"3","author":"Chan","year":"1991","journal-title":"Drug investigations"},{"issue":"3","key":"10.1002\/14651858.CD007451.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0167-5273(92)90238-X","article-title":"The application of nebivolol in essential hypertension: a double-blind, randomized, placebo-controlled study","volume":"35","author":"Chan","year":"1992","journal-title":"International Journal of Cardiology"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/j.1552-4604.1992.tb03789.x","article-title":"Antihypertensive and metabolic effects of single and combined atenolol regimens","volume":"32","author":"Chrysant","year":"1992","journal-title":"Journal of Clinical Pharmacology"},{"issue":"9","key":"10.1002\/14651858.CD007451.pub2-BIB0012|cit12","first-page":"321","article-title":"Atenolol as primary therapy in previously untreated hypertensives and as an adjuvant to other therapy. A South African multicentre study","volume":"Suid-Afrikaanse","author":"Cilliers","year":"1979","journal-title":"South African Medical Journal"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00005344-198601000-00009","article-title":"Pafenolol in hypertension: a double-blind randomized trial of a new beta 1-selective adrenoceptor blocker","volume":"8","author":"Dahlof","year":"1986","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"5","key":"10.1002\/14651858.CD007451.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/clc.4960170509","article-title":"Bisoprolol, a once-a-day beta-blocking agent for patients with mild to moderate hypertension","volume":"17","author":"Davidov","year":"1994","journal-title":"Clinical Cardiology"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00004872-200204000-00037","article-title":"Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs","volume":"20","author":"Deary","year":"2002","journal-title":"Journal of Hypertension"},{"issue":"5","key":"10.1002\/14651858.CD007451.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1042\/cs1030493","article-title":"Influence of drugs and gender on the arterial pulse wave and natriuretic peptide secretion in untreated patients with essential hypertension.[see comment]","volume":"103","author":"Deary","year":"2002","journal-title":"Clinical Science"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/HJH.0b013e3282f283c9","article-title":"A comparison of atenolol and nebivolol in isolated systolic hypertension","volume":"26","author":"Dhakam","year":"2008","journal-title":"Journal of Hypertension"},{"issue":"2","key":"10.1002\/14651858.CD007451.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/j.1552-4604.1995.tb05009.x","article-title":"First-line therapy option with low-dose bisoprolol fumarate and low-dose hydrochlorothiazide in patients with stage I and stage II systemic hypertension","volume":"35","author":"Frishman","year":"1995","journal-title":"Journal of Clinical Pharmacology"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.amjhyper.2005.10.007","article-title":"A factorial study of combination hypertension treatment with metoprolol succinate extended release and felodipine extended release results of the Metoprolol Succinate-Felodipine Antihypertension Combination Trial (M-FACT)","volume":"19","author":"Frishman","year":"2006","journal-title":"American Journal of Hypertension"},{"issue":"3","key":"10.1002\/14651858.CD007451.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2281.1985.tb00022.x","article-title":"Haemodynamic and metabolic responses to prolonged exercise after chronic beta 1-adrenoceptor blockade in hypertensive man","volume":"5","author":"Frisk-Holmberg","year":"1985","journal-title":"Clinical Physiology"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/S0140-6736(14)60614-0","article-title":"Efficacy and safety of nebivolol and valsartan as fixed-dose combination in hypertension: a randomised, multicentre study","volume":"383","author":"Giles","year":"2014","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD007451.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1185\/03007997709110161","article-title":"A dose-response study of atenolol in mild to moderate hypertension in general practice","volume":"5","author":"Gostick","year":"1977","journal-title":"Current Medical Research & Opinion"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-2362.1997.670617.x","article-title":"The effect of metoprolol treatment on insulin sensitivity and diurnal plasma hormone levels in hypertensive subjects","volume":"27","author":"Gudbjornsdottir","year":"1997","journal-title":"European Journal of Clinical Investigation"},{"issue":"5967","key":"10.1002\/14651858.CD007451.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/bmj.2.5967.367","article-title":"Controlled study of atenolol in treatment of hypertension","volume":"2","author":"Hansson","year":"1975","journal-title":"British Medical Journal"},{"issue":"3-4","key":"10.1002\/14651858.CD007451.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s002280050194","article-title":"Haemodynamic effects and pharmacokinetics of oral d- and l-nebivolol in hypertensive patients","volume":"51","author":"Himmelmann","year":"1996","journal-title":"European Journal of Clinical Pharmacology"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0002-8703(90)90175-W","article-title":"The effects of clonidine hydrochloride versus atenolol monotherapy on serum lipids, lipid subfractions, and apolipoproteins in mild hypertension","volume":"120","author":"Houston","year":"1990","journal-title":"American Heart Journal"},{"issue":"2 Suppl","key":"10.1002\/14651858.CD007451.pub2-BIB0027|cit27","first-page":"S66","article-title":"The efficacy of low dose metoprolol CR\/ZOK in mild hypertension and in elderly patients with mild to moderate hypertension","volume":"30","author":"Jaattela","year":"1990","journal-title":"Journal of Clinical Pharmacology"},{"issue":"5","key":"10.1002\/14651858.CD007451.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2125.1977.tb00780.x","article-title":"Atenolol once-daily in hypertension","volume":"4","author":"Jeffers","year":"1977","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0029|cit29","first-page":"283","article-title":"Placebo-controlled comparison of the effects of nebivolol and low-dose hydrochlorothiazide as monotherapies and in combination on blood pressure and lipid profile in hypertensive patients","volume":"8","author":"Lacourciere","year":"1994","journal-title":"Journal of Human Hypertension"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1475-097X.1983.tb00696.x","article-title":"Effect of long-term beta-adrenergic-blockade on calf blood flow in hypertensive patients","volume":"3","author":"Lepantalo","year":"1983","journal-title":"Clinical Physiology"},{"issue":"2","key":"10.1002\/14651858.CD007451.pub2-BIB0031|cit31","first-page":"225","article-title":"Lower limb haemodynamics during antihypertensive treatment with metoprolol and propranolol","volume":"4","author":"Lepantalo","year":"1985","journal-title":"International Angiology"},{"issue":"1 Pt 1","key":"10.1002\/14651858.CD007451.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/10600280870211P106","article-title":"Atenolol vs. amiloride-hydrochlorothiazide in the treatment of mild to moderate hypertension: a double-blind, crossover, placebo-controlled study","volume":"21","author":"Lischner","year":"1987","journal-title":"Drug Intelligence & Clinical Pharmacy"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2125.1990.tb03664.x","article-title":"Comparison of once daily atenolol, nitrendipine and their combination in mild to moderate essential hypertension","volume":"29","author":"Maclean","year":"1990","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/01.HYP.5.4.591","article-title":"Effects of atenolol and hydrochlorothiazide on blood pressure and plasma catecholamines in essential hypertension","volume":"5","author":"Myers","year":"1983","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0035|cit35","unstructured":"Mylan Bertek Pharmaceuticals A study of the safety and efficacy of nebivolol in hypertensive patients http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2007\/021742s000TOC.cfm (accessed Oct 2011)"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/000331978603700315","article-title":"Dose response studies of bevantolol in hypertensive patients","volume":"37","author":"Okawa","year":"1986","journal-title":"Angiology"},{"issue":"12","key":"10.1002\/14651858.CD007451.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.amjhyper.2006.05.007","article-title":"Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazide combination","volume":"19","author":"Papademetriou","year":"2006","journal-title":"American Journal of Hypertension"},{"issue":"6028","key":"10.1002\/14651858.CD007451.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/bmj.2.6028.137","article-title":"Methyldopa and propranolol or practolol in moderate hypertension","volume":"2","author":"Petrie","year":"1976","journal-title":"British Medical Journal"},{"issue":"6231","key":"10.1002\/14651858.CD007451.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1136\/bmj.280.6231.1573","article-title":"Atenolol, sustained-release oxprenolol, and long-acting propranolol in hypertension","volume":"280","author":"Petrie","year":"1980","journal-title":"British Medical Journal"},{"issue":"2","key":"10.1002\/14651858.CD007451.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF01542095","article-title":"Sexual sequelae of antihypertensive drugs: treatment effects on self-report and physiological measures in middle-aged male hypertensives","volume":"23","author":"Rosen","year":"1994","journal-title":"Archives of Sexual Behavior"},{"issue":"11","key":"10.1002\/14651858.CD007451.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/j.1524-6175.2007.07548.x","article-title":"The efficacy and tolerability of nebivolol in hypertensive African American patients","volume":"9","author":"Saunders","year":"2007","journal-title":"Journal of Clinical Hypertension"},{"issue":"6250","key":"10.1002\/14651858.CD007451.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1136\/bmj.281.6250.1241","article-title":"Trial of atenolol and chlorthalidone for hypertension in black South Africans","volume":"281","author":"Seedat","year":"1980","journal-title":"British Medical Journal"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000186378","article-title":"Comparative effects of enalapril, atenolol and chlorthalidone on blood pressure and kidney function of diabetic patients affected by arterial hypertension and persistent proteinuria","volume":"58","author":"Stornello","year":"1991","journal-title":"Nephron"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0044|cit44","first-page":"73","article-title":"A comparison of celiprolol and atenolol in the treatment of hypertension: a placebo controlled double blind study","volume":"Supplement. 40","author":"Stumpe","year":"1985","journal-title":"British Journal of Clinical Practice"},{"issue":"11","key":"10.1002\/14651858.CD007451.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/00004872-199011000-00007","article-title":"Diltiazem and atenolol in essential hypertension: additivity of effects on blood pressure and cardiac conduction with combination therapy","volume":"8","author":"Tonkin","year":"1990","journal-title":"Journal of Hypertension"},{"issue":"3","key":"10.1002\/14651858.CD007451.pub2-BIB0046|cit46","first-page":"155","article-title":"Short-term efficacy and safety of bisoprolol in treatment of patients with mild-to-moderate essential hypertension - a two-center, double-blind study in Taiwan","volume":"9","author":"Tseng","year":"1993","journal-title":"Acta Cardiologica Sinica"},{"issue":"6","key":"10.1002\/14651858.CD007451.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1097\/00005344-199306000-00002","article-title":"Nebivolol in hypertension: a double-blind placebo-controlled multicenter study assessing its antihypertensive efficacy and impact on quality of life","volume":"21","author":"Bortel","year":"1993","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"11","key":"10.1002\/14651858.CD007451.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/00004872-199111000-00013","article-title":"Effect of antihypertensive medication on endurance exercise capacity in hypertensive sportsmen","volume":"9","author":"Vanhees","year":"1991","journal-title":"Journal of Hypertension"},{"issue":"6","key":"10.1002\/14651858.CD007451.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00561057","article-title":"Haemodynamic effects of adrenaline during treatment of hypertensive patients with propranolol and metoprolol","volume":"12","author":"Herwaarden","year":"1977","journal-title":"European Journal of Clinical Pharmacology"},{"issue":"6","key":"10.1002\/14651858.CD007451.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"S262","DOI":"10.1097\/00004872-198900076-00127","article-title":"Verapamil and nebivolol improve carotid artery distensibility in hypertensive patients","volume":"7","author":"Merode","year":"1989","journal-title":"Journal of Hypertension - Supplement"},{"issue":"2","key":"10.1002\/14651858.CD007451.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.jhh.1000392","article-title":"A dose-response trial of nebivolol in essential hypertension","volume":"11","author":"Nueten","year":"1997","journal-title":"Journal of Human Hypertension"},{"issue":"2","key":"10.1002\/14651858.CD007451.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/sj.jhh.1000571","article-title":"Nebivolol vs atenolol and placebo in essential hypertension: a double-blind randomised trial","volume":"12","author":"Nueten","year":"1998","journal-title":"Journal of Human Hypertension"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/01.HYP.5.1.140","article-title":"Systolic time intervals as possible predictors of pressure response to sustained beta-adrenergic blockade in arterial hypertension. A within-patient, placebo-controlled study","volume":"5","author":"Verdecchia","year":"1983","journal-title":"Hypertension"},{"issue":"11","key":"10.1002\/14651858.CD007451.pub2-BIB0054|cit54","first-page":"570","article-title":"Duration of the antihypertensive action of atenolol, enalapril and placebo: a randomized within-patient study using ambulatory blood pressure monitoring","volume":"26","author":"Verdecchia","year":"1988","journal-title":"International Journal of Clinical Pharmacology, Therapy, & Toxicology"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0055|cit55","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1751-7176.2007.tb00010.x","article-title":"Erratum","volume":"9","author":"(2007)","year":"2007","journal-title":"The Journal of Clinical Hypertension"},{"issue":"9","key":"10.1002\/14651858.CD007451.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1524-6175.2007.06679.x","article-title":"A randomized, double-blind, placebo-controlled parallel-group study to assess the efficacy and safety of nebivolol, a novel beta-blocker, in patients with mild to moderate hypertension","volume":"9","author":"Weiss","year":"2007","journal-title":"Journal of Clinical Hypertension"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/j.1552-4604.1992.tb03848.x","article-title":"Dose-dependent effect of betaxolol in hypertension: A double-blind, multicenter study","volume":"32","author":"William","year":"1992","journal-title":"Journal of Clinical Pharmacology"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/10641968809046803","article-title":"Enalapril and atenolol in essential hypertension: attenuation of hypotensive effects in combination","volume":"10","author":"Wing","year":"1988","journal-title":"Clinical & Experimental Hypertension - Part A, Theory & Practice"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.clinthera.2008.11.003","article-title":"A 16-week, randomized, double-blind, placebo-controlled, crossover trial to quantify the combined effect of an angiotensin-converting enzyme inhibitor and a beta-blocker on blood pressure reduction","volume":"30","author":"Wald","year":"2008","journal-title":"Clinical Therapeutics"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0060|cit60","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007185.pub2","article-title":"Blood pressure lowering efficacy of beta-blockers as second-line therapy for primary hypertension","author":"Chen","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD007451.pub2-BIB0061|cit61","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003654.pub4","article-title":"Calcium channel blockers versus other classes of drugs for hypertension","author":"Chen","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0062|cit62","unstructured":"Deeks JJ Higgins JPT Altman DG (editors) Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0063|cit63","unstructured":"Canadian Pharmacist Association https:\/\/www.e-therapeutics.ca\/cps.showMonograph.action Accessed October 2012"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0064|cit64","unstructured":"FDA Online Label Repository http:\/\/labels.fda.gov\/ Accessed May 2013"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/BF03029726","article-title":"The applied pharmacology of beta-adrenoceptor antagonists (beta blockers) in relation to clinical outcomes","volume":"5","author":"Fitzgerald","year":"1991","journal-title":"Cardiovascular drugs and therapy"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0066|cit66","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003823.pub2","article-title":"Blood pressure lowering efficacy of angiotensin converting enzyme (ACE) inhibitors for primary hypertension","author":"Heran","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0067|cit67","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003822.pub2","article-title":"Blood pressure lowering efficacy of angiotensin receptor blockers for primary hypertension","author":"Heran","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0068|cit68","unstructured":"Higgins JPT Altman DG Sterne JAC (editors) Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0069|cit69","unstructured":"Higgins JPT Deeks JJ Altman DG (editors) Chapter 16: Special topics in statistics. In: Higgins JPT, Green S (editors), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/01.RES.87.12.1095","article-title":"Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C","volume":"87","author":"Kamp","year":"2000","journal-title":"Circulation Research."},{"key":"10.1002\/14651858.CD007451.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2165\/00003495-198836030-00002","article-title":"Bisoprolol: a preliminary review of its pharmacodynamic and pharmacokinetics properties and therapeutics efficacy in hypertension and angina pectoris","volume":"36","author":"Lancaster","year":"1988","journal-title":"Drugs"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1161\/CIRCULATIONAHA.104.529628","article-title":"Headaches and the treatment of blood pressure results from a meta-analysis of 94 randomized placebo-controlled trials with 24 000 participants","volume":"112","author":"Law","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0073|cit73","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002863","article-title":"Oral beta-blockers for mild to moderate hypertension during pregnancy","author":"Magee","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD007451.pub2-BIB0074|cit74","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007066.pub2","article-title":"Blood pressure lowering efficacy of renin inhibitors for primary hypertension","author":"Musini","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD007451.pub2-BIB0075|cit75","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003824.pub2","article-title":"Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension","author":"Musini","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1001\/archinte.1985.00360070203037","article-title":"The relative antihypertensive potency of propranolol, oxpranolol, atenolol and metoprolol given once daily","volume":"145","author":"Ravid","year":"1985","journal-title":"Archive Internal Medicine"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0077|cit77","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0078|cit78","unstructured":"Sterne JAC Egger M Moher D (editors) Chapter 10: Addressing reporting biases. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Intervention. Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"7-8","key":"10.1002\/14651858.CD007451.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1345\/aph.1G708","article-title":"Nebivolol: A third generation beta adrenergic blocker","volume":"40","author":"Veverka","year":"2006 Jul-Aug","journal-title":"Annals of Pharmacotherapy"},{"key":"10.1002\/14651858.CD007451.pub2-BIB0080|cit80","article-title":"Ch. 8 Neurotransmission: The autonomic and somatic motor nervous systems","volume-title":"Goodman & Gilman's The Pharmacological Basis of Therapeutics","author":"Westfall","year":"2011"},{"issue":"11","key":"10.1002\/14651858.CD007451.pub2-BIB0081|cit81","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002003.pub4","article-title":"Beta-blockers for hypertension","author":"Wiysonge","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD007451.pub2-BIB0082|cit82","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007452.pub2","article-title":"Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension","author":"Wong","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD007451.pub2-BIB0083|cit83","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007450.pub2","article-title":"Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension","author":"Wong","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD007451.pub2-BIB0084|cit84","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007449.pub2","article-title":"Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension","author":"Wong","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD007451.pub2-BIB0085|cit85","first-page":"188","article-title":"Choosing a first-line drug in the management of elevated blood pressure: What is the evidence? 2: \u03b2-Blockers","volume":"163","author":"Wright","year":"2000","journal-title":"Canadian Medical Association Journal"},{"issue":"3","key":"10.1002\/14651858.CD007451.pub2-BIB0086|cit86","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001841.pub2","article-title":"First-line drugs for hypertension","author":"Wright","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD007451.pub2-BIB0087|cit87","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008170.pub2","article-title":"First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive drug classes for hypertension","author":"Xue","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD007451.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T18:32:40Z","timestamp":1748802760000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007451.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Hypertension Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,10]]},"references-count":87,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007451.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,10]]}}}