{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:25:45Z","timestamp":1789392345975,"version":"build-2803163510"},"update-to":[{"DOI":"10.1002\/14651858.cd007524.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000}}],"reference-count":84,"publisher":"Wiley","issue":"6","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007524.pub4","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T19:52:58Z","timestamp":1465329178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children"],"prefix":"10.1002","volume":"2016","author":[{"given":"Kayleigh M","family":"Kew","sequence":"first","affiliation":[{"name":"St George's, University of London; Population Health Research Institute; Cranmer Terrace London UK SW17 0RE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Quinn","sequence":"additional","affiliation":[{"name":"St George's, University of London; Population Health Research Institute; Cranmer Terrace London UK SW17 0RE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley S","family":"Quon","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Medicine; #31-795 West 8th Avenue Vancouver BC Canada V5Z 1C9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine M","family":"Ducharme","sequence":"additional","affiliation":[{"name":"University of Montreal; Department of Paediatrics; Montreal Canada"},{"name":"CHU Sainte-Justine; Research Centre; Montreal Canada"},{"name":"University of Montreal; Department of Social and Preventive Medicine; Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"issue":"7","key":"10.1002\/14651858.CD007524.pub4-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1136\/thx.2003.014936","article-title":"Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations","volume":"59","author":"FitzGerald","year":"2004","journal-title":"Thorax"},{"issue":"2","key":"10.1002\/14651858.CD007524.pub4-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1378\/chest.117.2.440","article-title":"Low-dose budesonide with the addition of an increased dose during exacerbations is effective in long-term asthma control","volume":"117","author":"Foresi","year":"2000","journal-title":"Chest"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/adc.79.1.12","article-title":"Treatment of acute asthmatic exacerbations with an increased dose of inhaled steroid","volume":"79","author":"Garrett","year":"1998","journal-title":"Archives of Disease in Childhood"},{"issue":"9405","key":"10.1002\/14651858.CD007524.pub4-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0140-6736(03)15384-6","article-title":"Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial","volume":"363","author":"Harrison","year":"2004","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0140-6736(10)62145-9","article-title":"Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial","volume":"377","author":"Martinez","year":"2011","journal-title":"Lancet"},{"issue":"7","key":"10.1002\/14651858.CD007524.pub4-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1164\/rccm.200904-0616OC","article-title":"Quadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: a randomized, double blind, placebo controlled, parallel group, clinical trial","volume":"180","author":"Oborne","year":"2009","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"12","key":"10.1002\/14651858.CD007524.pub4-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1445-5994.2005.00972.x","article-title":"Doubling daily inhaled corticosteroid dose is ineffective in mild to moderately severe attacks of asthma in adults","volume":"35","author":"Rice-McDonald","year":"2005","journal-title":"Internal Medicine Journal"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0008|cit8","unstructured":"Wainwright C A multicentre randomised controlled trial of treatment of acute exacerbations of asthma in children with a doubling of the usual inhaled corticosteroid (ICS) dose to identify efficacy of intervention https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=630"},{"issue":"3","key":"10.1002\/14651858.CD007524.pub4-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.pupt.2007.11.002","article-title":"Randomized comparison of ciclesonide 160 and 640 mug\/day in severe asthma","volume":"21","author":"Bateman","year":"2008","journal-title":"Pulmonary Pharmacology and Therapeutics"},{"issue":"15","key":"10.1002\/14651858.CD007524.pub4-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1056\/NEJMoa042552","article-title":"Daily versus as-needed corticosteroids for mild persistent asthma","volume":"352","author":"Boushey","year":"2005","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"10.1002\/14651858.CD007524.pub4-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.rmed.2011.07.017","article-title":"Ciclesonide in wheezy preschool children with a positive asthma predictive index or atopy","volume":"105","author":"Brand","year":"2011","journal-title":"Respiratory Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007524.pub4-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0735-6757(96)90120-5","article-title":"Early corticosteroid use in acute exacerbations of chronic airflow obstruction","volume":"14","author":"Bullard","year":"1996","journal-title":"American Journal of Emergency Medicine"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0013|cit13","volume-title":"Airway challenges in different clinical phenotypes and their relationship to markers of disease and treatment [PhD thesis]","author":"Clearie","year":"2010"},{"issue":"4","key":"10.1002\/14651858.CD007524.pub4-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1081-1206(10)63288-7","article-title":"The addition of salmeterol to fluticasone propionate versus increasing the dose of fluticasone propionate in patients with persistent asthma","volume":"82","author":"Condemi","year":"1999","journal-title":"Annals of Allergy, Asthma and Immunology"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/adc.68.1.85","article-title":"Prevention of viral induced asthma attacks using inhaled budesonide","volume":"68","author":"Connett","year":"1993","journal-title":"Archives of Disease in Childhood"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00228-003-0571-9","article-title":"Effects of fluticasone plus salmeterol versus twice the dose of fluticasone in asthmatic patients","volume":"59","author":"Currie","year":"2003","journal-title":"European Journal of Clinical Pharmacology"},{"issue":"5","key":"10.1002\/14651858.CD007524.pub4-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1081\/JAS-200062966","article-title":"Nebulized fluticasone propionate vs. budesonide as adjunctive treatment in children with asthma exacerbation","volume":"42","author":"Benedictis","year":"2005","journal-title":"Journal of Asthma"},{"issue":"8","key":"10.1002\/14651858.CD007524.pub4-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1651-2227.1999.tb00057.x","article-title":"Efficacy of nebulized budesonide compared to oral prednisolone in acute bronchial asthma","volume":"88","author":"Devidayal","year":"1999","journal-title":"Acta Paediatrica\u00a0"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1155\/2000\/587957","article-title":"A randomized, controlled trial of high dose, inhaled budesonide versus oral prednisone in patients discharged from the emergency department following an acute asthma exacerbation","volume":"7","author":"FitzGerald","year":"2000","journal-title":"Canadian Respiratory Journal"},{"issue":"8917","key":"10.1002\/14651858.CD007524.pub4-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(94)92996-3","article-title":"Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid","volume":"344","author":"Greening","year":"1994","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0021|cit21","unstructured":"GlaxoSmithKline A multicentre, double-blind, randomised, four-week, parallel-group comparison of inhaled fluticasone propionate and inhaled beclomethasone dipropionate in patients with severe asthma controlled by high-dose inhaled corticosteroids (FLIP04) http:\/\/www.gsk-clinicalstudyregister.com\/study\/FMS30049#rs"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1651-2227.1999.tb01267.x","article-title":"Systemic effects of a short course of betamethasone compared with high-dose inhaled budesonide in early childhood asthma","volume":"88","author":"Hedlin","year":"1999","journal-title":"Acta Paediatrica"},{"issue":"9","key":"10.1002\/14651858.CD007524.pub4-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0954-6111(99)90100-2","article-title":"The effect of high-dose fluticasone propionate and budesonide on lung function and asthma exacerbations in patients with severe asthma","volume":"93","author":"Heinig","year":"1999","journal-title":"Respiratory Medicine"},{"issue":"3","key":"10.1002\/14651858.CD007524.pub4-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.rmed.2006.06.005","article-title":"Inhaled mometasone furoate reduces oral prednisone usage and improves lung function in severe persistent asthma","volume":"101","author":"Karpel","year":"2007","journal-title":"Respiratory Medicine"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/pai.1997.11.23","article-title":"Double-blind study of inhaled salbutamol versus salbutamol plus high-dose flunisolide in exacerbation of bronchial asthma: a pilot study","volume":"11","author":"Rosa","year":"1997","journal-title":"Pediatric Asthma, Allergy and Immunology"},{"issue":"4","key":"10.1002\/14651858.CD007524.pub4-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1378\/chest.122.4.1208","article-title":"Comparison of high-dose inhaled flunisolide to systemic corticosteroids in severe adult asthma","volume":"122","author":"Lee-Wong","year":"2002","journal-title":"Chest"},{"issue":"11","key":"10.1002\/14651858.CD007524.pub4-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1056\/NEJMoa1001278","article-title":"Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids","volume":"362","author":"Lemanske","year":"2010","journal-title":"New England Journal of Medicine"},{"issue":"1-2","key":"10.1002\/14651858.CD007524.pub4-BIB0028|cit28","first-page":"7","article-title":"A single high dose of inhaled corticosteroids: a possible treatment of asthma exacerbations","volume":"132","author":"Leuppi","year":"2002","journal-title":"Swiss Medical Weekly"},{"issue":"11","key":"10.1002\/14651858.CD007524.pub4-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1136\/thx.51.11.1087","article-title":"Comparison of short courses of oral prednisolone and fluticasone propionate in the treatment of adults with acute exacerbations of asthma in primary care","volume":"51","author":"Levy","year":"1996","journal-title":"Thorax"},{"issue":"12","key":"10.1002\/14651858.CD007524.pub4-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1053\/rmed.2000.0952","article-title":"Efficacy of nebulized fluticasone propionate compared with oral prednisolone in children with an acute exacerbation of asthma","volume":"94","author":"Manjra","year":"2000","journal-title":"Respiratory Medicine"},{"issue":"5","key":"10.1002\/14651858.CD007524.pub4-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1067\/mai.2001.114709","article-title":"Addition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: an analysis of asthma exacerbations","volume":"107","author":"Matz","year":"2001","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"2","key":"10.1002\/14651858.CD007524.pub4-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2223\/1148","article-title":"Nebulized budesonide to treat acute asthma in children","volume":"80","author":"Milani","year":"2004","journal-title":"Jornal de Pediatria"},{"issue":"8","key":"10.1002\/14651858.CD007524.pub4-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3109\/02770909809048967","article-title":"High-dose inhaled budesonide may substitute for oral therapy after an acute asthma attack","volume":"35","author":"Nana","year":"1998","journal-title":"Journal of Asthma"},{"issue":"3","key":"10.1002\/14651858.CD007524.pub4-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1081-1206(10)63306-6","article-title":"The effectiveness of high-dose inhaled budesonide therapy in the treatment of acute asthma exacerbations in children","volume":"86","author":"Nuhoglu","year":"2001","journal-title":"Annals of Allergy, Asthma, and Immunology"},{"issue":"17","key":"10.1002\/14651858.CD007524.pub4-BIB0035|cit35","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1517\/14656566.2010.526603","article-title":"Efficacy and safety of ciclesonide in patients with severe asthma: a 12-week, double-blind, randomized, parallel-group study with long-term (1-year) follow-up","volume":"11","author":"O'Connor","year":"2010","journal-title":"Expert Opinion on Pharmacotherapy"},{"issue":"3","key":"10.1002\/14651858.CD007524.pub4-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pupt.2008.12.013","article-title":"Efficacy and safety of ciclesonide once daily and fluticasone propionate twice daily in children with asthma","volume":"22","author":"Pedersen","year":"2009","journal-title":"Pulmonary Pharmacology and Therapeutics"},{"issue":"4","key":"10.1002\/14651858.CD007524.pub4-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S1081-1206(10)60601-1","article-title":"Comparison of single 2000-microg dose treatment vs. sequential repeated-dose 500-microg treatments with nebulized budesonide in acute asthma exacerbations","volume":"100","author":"Razi","year":"2008","journal-title":"Annals of Allergy, Asthma, and Immunology"},{"issue":"3 Pt 1","key":"10.1002\/14651858.CD007524.pub4-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1164\/ajrccm.157.3.9704022","article-title":"Inhaled flunisolide for acute severe asthma","volume":"157","author":"Rodrigo","year":"1998","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"11","key":"10.1002\/14651858.CD007524.pub4-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1164\/rccm.200410-1415OC","article-title":"Comparison of inhaled fluticasone with intravenous hydrocortisone in the treatment of adult acute asthma","volume":"171","author":"Rodrigo","year":"2005","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"10","key":"10.1002\/14651858.CD007524.pub4-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJM200009073431003","article-title":"A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma","volume":"343","author":"Schuh","year":"2000","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007524.pub4-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1542\/peds.2005-2842","article-title":"High-dose inhaled fluticasone does not replace oral prednisolone in children with mild to moderate acute asthma","volume":"118","author":"Schuh","year":"2006","journal-title":"Pediatrics"},{"issue":"10","key":"10.1002\/14651858.CD007524.pub4-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1080\/08035250510039847","article-title":"The effect of nebulized budesonide treatment in children with mild to moderate exacerbations of asthma","volume":"94","author":"Sekerel","year":"2005","journal-title":"Acta Paediatrica"},{"issue":"5","key":"10.1002\/14651858.CD007524.pub4-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1046\/j.1440-1754.1999.355408.x","article-title":"Inhaled budesonide in acute asthma","volume":"35","author":"Singhi","year":"1999","journal-title":"Journal of Paediatrics and Child Health"},{"issue":"8","key":"10.1002\/14651858.CD007524.pub4-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1651-2227.1995.tb13786.x","article-title":"Intermittent treatment with inhaled steroids for deterioration of asthma due to upper respiratory tract infections","volume":"84","author":"Svedmyr","year":"1995","journal-title":"Acta Paediatrica"},{"issue":"4 Pt 1","key":"10.1002\/14651858.CD007524.pub4-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0091-6749(98)70276-3","article-title":"Effectiveness and safety of inhaled corticosteroids in controlling acute asthma attacks in children who were treated in the emergency department: a controlled comparative study with oral prednisolone","volume":"102","author":"Volovitz","year":"1998","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"4","key":"10.1002\/14651858.CD007524.pub4-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/adc.65.4.407","article-title":"Treatment of acute, episodic asthma in preschool children using intermittent high dose inhaled steroids at home","volume":"65","author":"Wilson","year":"1990","journal-title":"Archives of Disease in Childhood"},{"issue":"6","key":"10.1002\/14651858.CD007524.pub4-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2500\/aap.2012.33.3614","article-title":"Early intervention with high-dose inhaled corticosteroids for control of acute asthma exacerbations at home and improved outcomes: a randomized controlled trial","volume":"33","author":"Yousef","year":"2012","journal-title":"Allergy and Asthma Proceedings"},{"issue":"2 Suppl 1","key":"10.1002\/14651858.CD007524.pub4-BIB0048|cit48","first-page":"AB85","article-title":"Ineffectiveness of high-dose inhaled corticosteroids for control of pre-exacerbation asthma symptoms","volume":"127","author":"Yousef","year":"2011","journal-title":"Journal of Allergy and Clinical Immunology (Abstract)"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0049|cit49","unstructured":"Step-up Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02066129"},{"issue":"4","key":"10.1002\/14651858.CD007524.pub4-BIB0050|cit50","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003274","article-title":"Budesonide versus placebo for chronic asthma in children and adults","author":"Adams","year":"1999","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1183\/09031936.93.06060877","article-title":"A comparison of fluticasone propionate, 1 mg daily, with beclomethasone dipropionate, 2 mg daily, in the treatment of severe asthma","volume":"6","author":"Barnes","year":"1993","journal-title":"European Respiratory Journal"},{"issue":"6","key":"10.1002\/14651858.CD007524.pub4-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1183\/09031936.00050306","article-title":"Anti-inflammatory effects of high-dose inhaled fluticasone versus oral prednisone in asthma exacerbations","volume":"30","author":"Belda","year":"2007","journal-title":"European Respiratory Journal"},{"issue":"Suppl 11","key":"10.1002\/14651858.CD007524.pub4-BIB0053|cit53","first-page":"S1","article-title":"Canadian Asthma Consensus Report, 1999. Canadian Asthma Consensus Group","volume":"161","author":"Boulet","year":"1999","journal-title":"CMAJ"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007524.pub4-BIB0054|cit54","first-page":"S1","article-title":"British guidelines on asthma management","volume":"52","author":"British Thoracic Society","year":"1997","journal-title":"Thorax"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0055|cit55","unstructured":"British Thoracic Society\/Scottish Intercollegiate Guidelines Network British guideline on the management of asthma: a national clinical guideline http:\/\/sign.ac.uk\/pdf\/SIGN141.pdf"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"issue":"4","key":"10.1002\/14651858.CD007524.pub4-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMoa0808907","article-title":"Preemptive use of high-dose fluticasone for virus-induced wheezing in young children","volume":"360","author":"Ducharme","year":"2009","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002308","article-title":"Early use of inhaled corticosteroids in the emergency department treatment of acute asthma","author":"Edmonds","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"issue":"5","key":"10.1002\/14651858.CD007524.pub4-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0002-9343(83)91076-8","article-title":"Glucocorticoids in acute asthma. A critical controlled trial","volume":"74","author":"Fanta","year":"1983","journal-title":"American Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007524.pub4-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1037\/1082-989X.6.2.161","article-title":"Meta-analysis of correlation coefficients: a Monte Carlo comparison of fixed- and random-effects methods","volume":"6","author":"Fields","year":"2001","journal-title":"Psychological Methods"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0062|cit62","unstructured":"Global Initiative for Asthma Global strategy for asthma management and prevention http:\/\/www.ginasthma.org\/local\/uploads\/files\/GINA_Report_2015.pdf"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0063|cit63","unstructured":"Global Asthma Network Global Asthma Report 2015 http:\/\/www.globalasthmareport.org\/resources\/Global_Asthma_Report_2014.pdf"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2307\/2530643","article-title":"Estimation of a common effect parameter from sparse follow-up data","volume":"41","author":"Greenland","year":"1985","journal-title":"Biometrics"},{"issue":"7414","key":"10.1002\/14651858.CD007524.pub4-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0066|cit66","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011"},{"issue":"8","key":"10.1002\/14651858.CD007524.pub4-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/thx.2005.045161","article-title":"Asthma exacerbations. 1: epidemiology","volume":"61","author":"Johnston","year":"2006","journal-title":"Thorax"},{"issue":"3","key":"10.1002\/14651858.CD007524.pub4-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.rmed.2005.06.012","article-title":"An international observational prospective study to determine the cost of asthma exacerbations (COAX)","volume":"100","author":"Lane","year":"2006","journal-title":"Respiratory Medicine"},{"issue":"Suppl A","key":"10.1002\/14651858.CD007524.pub4-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"9A","DOI":"10.1155\/2004\/271362","article-title":"Adult Asthma Consensus Guidelines Update 2003","volume":"11","author":"Lemiere","year":"May\/June 2004","journal-title":"Canadian Respiratory Journal"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3132\/pcrj.2007.00002","article-title":"The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK","volume":"16","author":"Lloyd","year":"2007","journal-title":"Primary Care Respiratory Journal"},{"issue":"4","key":"10.1002\/14651858.CD007524.pub4-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0272-5231(05)70181-7","article-title":"Corticosteroids in chronic obstructive pulmonary disease. Clinical benefits and risks","volume":"21","author":"McEvoy","year":"2000","journal-title":"Clinical Chest Medicine"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0072|cit72","unstructured":"National Center for Health Statistics (NCHS) Centers for Disease Control and Prevention 2005 National Health Interview Survey (NHIS 2005). Hyattsville, MD http:\/\/www.cdc.gov\/nchs\/about\/major\/nhis\/reports_2005.htm (accessed 14 March 2008)"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0073|cit73","unstructured":"National Heart Lung Blood Institute Guidelines for the diagnosis and management of asthma (EPR-3) Bethesda, MD: National Institutes of Health, 2007."},{"issue":"9394","key":"10.1002\/14651858.CD007524.pub4-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0140-6736(03)14685-5","article-title":"Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1-5 years; randomised controlled trial","volume":"362","author":"Oommen","year":"2003","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMoa0804897","article-title":"Oral prednisolone for preschool children with acute virus-induced wheezing","volume":"360","author":"Panickar","year":"2009","journal-title":"New England Journal of Medicine"},{"issue":"9","key":"10.1002\/14651858.CD007524.pub4-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/archpedi.156.9.934","article-title":"A prospective multicenter study of patient factors associated with hospital admission from the emergency department among children with acute asthma","volume":"156","author":"Pollack","year":"2002","journal-title":"Archives of Pediatric & Adolescent Medicine"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0077|cit77","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"5","key":"10.1002\/14651858.CD007524.pub4-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1378\/chest.130.5.1301","article-title":"Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation","volume":"130","author":"Rodrigo","year":"2006","journal-title":"Chest"},{"issue":"1","key":"10.1002\/14651858.CD007524.pub4-BIB0079|cit79","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002178","article-title":"Early emergency department treatment of acute asthma with systemic corticosteroids","author":"Rowe","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0080|cit80","first-page":"1","article-title":"Natural history and epidemiology","volume-title":"Evidence based asthma management","author":"Sears","year":"2000"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/2046-4053-3-54","article-title":"Study flow diagrams in Cochrane systematic review updates: an adapted PRISMA flow diagram","volume":"3","author":"Stovold","year":"2014","journal-title":"Systematic Reviews"},{"key":"10.1002\/14651858.CD007524.pub4-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1164\/ajrccm.157.2.9703060","article-title":"A randomized trial comparing peak expiratory flow and symptom self-management plans for patients with asthma attending a primary care clinic","volume":"157","author":"Turner","year":"1998","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"21","key":"10.1002\/14651858.CD007524.pub4-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1056\/NEJMsr077003","article-title":"Special report. Statistics in medicine - reporting of subgroup analyses in clinical trials","volume":"357","author":"Wang","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD007524.pub4-BIB0084|cit84","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007524.pub3","article-title":"Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children","author":"Quon","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd007524.pub5","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD007524.pub4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T20:00:47Z","timestamp":1692388847000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007524.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Airways Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,7]]},"references-count":84,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007524.pub4","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD007524.pub5","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,7]]}}}