{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:48:59Z","timestamp":1782107339990,"version":"3.54.5"},"update-to":[{"DOI":"10.1002\/14651858.cd007742.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000}}],"reference-count":59,"publisher":"Wiley","issue":"1","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007742.pub4","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T14:25:10Z","timestamp":1483971910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Non-surgical interventions for acute internal hordeolum"],"prefix":"10.1002","volume":"2017","author":[{"given":"Kristina","family":"Lindsley","sequence":"first","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health; Department of Epidemiology; 615 North Wolfe Street, Mail Room E6132 Baltimore Maryland USA 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J","family":"Nichols","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham; Office of the Vice President for Research and Economic Development, Office of Industry Engagement, Clinical Trials Office; 1720 2nd Avenue South AB 714A Birmingham Alabama USA 35294-0107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Dickersin","sequence":"additional","affiliation":[{"name":"Johns Hopkins University; Center for Clinical Trials and US Cochrane Center; Bloomberg School of Public Health 615 North Wolfe Street, Mail Rm E6152 Baltimore MD USA 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"issue":"3","key":"10.1002\/14651858.CD007742.pub4-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/01676838609036048","article-title":"Comparative study of local injection therapy of chalazia","volume":"5","author":"Bahgat","year":"1986","journal-title":"Orbit"},{"issue":"1","key":"10.1002\/14651858.CD007742.pub4-BIB0002|cit2","first-page":"29","article-title":"Effective observation on 111 cases of hordeolum treated by bloodleting in the point of ear","volume":"22","author":"Chen","year":"2000","journal-title":"Journal of Guiyang College of Traditional Chinese Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007742.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2165\/11596320-000000000-00000","article-title":"Safety and tolerability of loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension in pediatric subjects","volume":"14","author":"Comstock","year":"2012","journal-title":"Paediatric Drugs"},{"issue":"7049","key":"10.1002\/14651858.CD007742.pub4-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S0140-6736(58)91337-0","article-title":"Treatment of recurrent styes","volume":"2","author":"Copeman","year":"1958","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD007742.pub4-BIB0005|cit5","first-page":"19","article-title":"Treatment of hordeolum by wrist-ankle acupuncture","volume":"20","author":"Gao","year":"2001","journal-title":"Shanghai Journal of Acupuncture and Moxibustion"},{"issue":"5","key":"10.1002\/14651858.CD007742.pub4-BIB0006|cit6","first-page":"196","article-title":"Adrenocorticosteroid injection vs. conservative therapy in the treatment of chalazia","volume":"20","author":"Garrett","year":"1988","journal-title":"Annals of Ophthalmology"},{"issue":"2","key":"10.1002\/14651858.CD007742.pub4-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0002-9394(70)91294-8","article-title":"Gentamicin sulfate in external eye infections","volume":"69","author":"Gordon","year":"1970","journal-title":"American Journal of Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD007742.pub4-BIB0008|cit8","first-page":"522","article-title":"Ophthalmological application of minocycline","volume":"22","author":"Hatano","year":"1969","journal-title":"Japanese Journal of Antibiotics"},{"issue":"4","key":"10.1002\/14651858.CD007742.pub4-BIB0009|cit9","first-page":"451","article-title":"Evaluation of amikacin (BB-K8) in ophthalmological field","volume":"27","author":"Hatano","year":"1974","journal-title":"Japanese Journal of Antibiotics"},{"issue":"5","key":"10.1002\/14651858.CD007742.pub4-BIB0010|cit10","first-page":"647","article-title":"Effectiveness of combined antibiotic ophthalmic solution in the treatment of hordeolum after incision and curettage: a randomized, placebo-controlled trial: a pilot study","volume":"88","author":"Hirunwiwatkul","year":"2005","journal-title":"Journal of the Medical Association of Thailand"},{"issue":"11","key":"10.1002\/14651858.CD007742.pub4-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1136\/bjo.68.11.836","article-title":"Intralesional corticosteroid therapy of chalazia: a comparison with incision and curettage","volume":"68","author":"Jacobs","year":"1984","journal-title":"British Journal of Ophthalmology"},{"issue":"10","key":"10.1002\/14651858.CD007742.pub4-BIB0012|cit12","first-page":"376","article-title":"Placebo-controlled, double-blind evaluation of the efficacy and safety of yellow mercuric oxide in suppression of eyelid infections","volume":"19","author":"Kastl","year":"1987","journal-title":"Annals of Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD007742.pub4-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0002-9394(14)75639-9","article-title":"A clinical comparison of tobramycin and gentamicin sulfate in the treatment of ocular infections","volume":"92","author":"Laibson","year":"1981","journal-title":"American Journal of Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD007742.pub4-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jama.1967.03120060125030","article-title":"Gentamicin sulfate in external eye infections","volume":"199","author":"Magnuson","year":"1967","journal-title":"JAMA"},{"issue":"4","key":"10.1002\/14651858.CD007742.pub4-BIB0015|cit15","first-page":"1041","article-title":"A double-blind study of tobramycin eye drops on infectious diseases of anterior portion of the eye. Comparison with gentamicin eye drops","volume":"32","author":"Manabe","year":"1981","journal-title":"Folia Ophthalmologica Japonica"},{"issue":"10","key":"10.1002\/14651858.CD007742.pub4-BIB0016|cit16","first-page":"689","article-title":"Munomycin in hordeolum externum","volume":"19","author":"Mathew","year":"1966","journal-title":"Indian Practitioner"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0017|cit17","unstructured":"NCT01763437 Intralesional tetracycline injection in the treatment of chalazia (TET) clinicaltrials.gov\/ct2\/show\/NCT01763437"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0018|cit18","unstructured":"NCT02338648 Safety and efficacy study of SUN 131 TDS as compared to placebo TDS in adult patients with a chalazion clinicaltrials.gov\/ct2\/show\/NCT02338648"},{"issue":"6","key":"10.1002\/14651858.CD007742.pub4-BIB0019|cit19","first-page":"535","article-title":"Clinical evaluation of clindamycin-2-palmitate for ophthalmic infections of children","volume":"26","author":"Oishi","year":"1973","journal-title":"Japanese Journal of Antibiotics"},{"issue":"4","key":"10.1002\/14651858.CD007742.pub4-BIB0020|cit20","first-page":"183","article-title":"Intralesional corticosteroid therapy of chalazia","volume":"35","author":"Panda","year":"1987","journal-title":"Indian Journal of Ophthalmology"},{"issue":"2","key":"10.1002\/14651858.CD007742.pub4-BIB0021|cit21","first-page":"51","article-title":"Laboratory and clinical evaluation of clindamycin","volume":"24","author":"Sawae","year":"1971","journal-title":"Japanese Journal of Antibiotics"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0022|cit22","first-page":"9","article-title":"The efficacy of hainou-san-kyu-to for internal hordeolum","volume":"100","author":"Takama","year":"2006","journal-title":"Ganka Rinsho Iho (Japanese Review of Clinical Ophthalmology)"},{"issue":"5","key":"10.1002\/14651858.CD007742.pub4-BIB0023|cit23","first-page":"374","article-title":"Kenalog injection\uff0done possibility in the treatment of chronic chalazion","volume":"43","author":"V\u00e1cha","year":"1987","journal-title":"Ceskoslovenska Oftalmologie"},{"issue":"3","key":"10.1002\/14651858.CD007742.pub4-BIB0024|cit24","first-page":"168","article-title":"Treatment of tarsal cyst by local injection of cortisone","volume":"19","author":"Wang","year":"1983","journal-title":"Zhonghua Yan Ke Za Zhi (Chinese Journal of Ophthalmology)"},{"issue":"11","key":"10.1002\/14651858.CD007742.pub4-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/bjo.68.11.833","article-title":"Treatment of chalazions with injection of a steroid suspension","volume":"68","author":"Watson","year":"1984","journal-title":"British Journal of Ophthalmology"},{"issue":"5","key":"10.1002\/14651858.CD007742.pub4-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/acm.2008.0012","article-title":"Traditional malian ointment for styes","volume":"14","author":"Willcox","year":"2008","journal-title":"Journal of Alternative and Complementary Medicine"},{"issue":"5","key":"10.1002\/14651858.CD007742.pub4-BIB0027|cit27","first-page":"47","article-title":"Clinical observation on 67 cases of hordeolum treated by acupuncture and blood letting on ear","volume":"10","author":"Xu","year":"2004","journal-title":"Hunan Guiding Journal of Traditional Chinese Medicine"},{"issue":"4","key":"10.1002\/14651858.CD007742.pub4-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1177\/106002809102500406","article-title":"Effect of I-Scrub on signs and symptoms of chronic blepharitis","volume":"25","author":"Avisar","year":"1991","journal-title":"DICP: the Annals of Pharmacotherapy"},{"issue":"1","key":"10.1002\/14651858.CD007742.pub4-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0025-7125(16)31228-7","article-title":"Ocular infections","volume":"67","author":"Barza","year":"1983","journal-title":"Medical Clinics of North America"},{"issue":"4","key":"10.1002\/14651858.CD007742.pub4-BIB0030|cit30","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011075","article-title":"Acupuncture for acute hordeolum","author":"Cheng","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0031|cit31","unstructured":"De Jesus JM Treating hordeola with systemic medications: first-line therapy with oral antibiotics for the treatment of hordeola may provide a more permanent resolution Pacific Optometry. www.opt.pacificu.edu\/test\/journal\/Articles\/deJesus%20hordeola\/hordeola.html"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0032|cit32","unstructured":"Deeks JJ Higgins JP Altman DG editor(s) Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JP, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"2","key":"10.1002\/14651858.CD007742.pub4-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/00325481.1986.11699502","article-title":"Eyelid problems. Blepharitis, hordeola, and chalazia","volume":"80","author":"Diegel","year":"1986","journal-title":"Postgraduate Medicine"},{"issue":"5","key":"10.1002\/14651858.CD007742.pub4-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0039-6257(96)80064-6","article-title":"Meibomian gland dysfunction","volume":"40","author":"Driver","year":"1996","journal-title":"Survey of Ophthalmology"},{"issue":"4","key":"10.1002\/14651858.CD007742.pub4-BIB0035|cit35","first-page":"104","article-title":"How to treat common external eye problems","volume":"3","author":"Fraunfelder","year":"1971","journal-title":"American Family Physician"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0036|cit36","volume-title":"Textbook of Ophthalmology","author":"Fuchs","year":"1911"},{"issue":"2","key":"10.1002\/14651858.CD007742.pub4-BIB0037|cit37","first-page":"130","article-title":"How to identify randomized controlled trials in MEDLINE: ten years on","volume":"94","author":"Glanville","year":"2006","journal-title":"Journal of the Medical Library Association"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0038|cit38","unstructured":"Higgins JP Altman DG Sterne JAC editor(s) Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"9","key":"10.1002\/14651858.CD007742.pub4-BIB0039|cit39","first-page":"714","article-title":"Treatment of styes and meibomian cysts. Practical procedures","volume":"10","author":"Hudson","year":"1981","journal-title":"Australian Family Physician"},{"issue":"6","key":"10.1002\/14651858.CD007742.pub4-BIB0040|cit40","first-page":"351","article-title":"Treatment of chalazia with corticosteroid injections","volume":"17","author":"King","year":"1986","journal-title":"Ophthalmic Surgery"},{"issue":"2","key":"10.1002\/14651858.CD007742.pub4-BIB0041|cit41","first-page":"133","article-title":"Treatment of hordeola","volume":"7","author":"Lebensohn","year":"1950","journal-title":"Postgraduate Medicine"},{"issue":"8","key":"10.1002\/14651858.CD007742.pub4-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1542\/pir.20.8.283","article-title":"Hordeola and chalazia","volume":"20","author":"Lederman","year":"1999","journal-title":"Pediatrics in Review"},{"issue":"2","key":"10.1002\/14651858.CD007742.pub4-BIB0043|cit43","first-page":"65","article-title":"Blepharoconjunctivitis","volume":"24","author":"McCulley","year":"1984","journal-title":"International Ophthalmology Clinics"},{"issue":"1367","key":"10.1002\/14651858.CD007742.pub4-BIB0044|cit44","first-page":"901","article-title":"Eyelid problems","volume":"226","author":"Moriarty","year":"1982","journal-title":"Practitioner"},{"issue":"1","key":"10.1002\/14651858.CD007742.pub4-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.emc.2007.10.004","article-title":"Ocular infection and inflammation","volume":"26","author":"Mueller","year":"2008","journal-title":"Emergency Medicine Clinics of North America"},{"issue":"2","key":"10.1002\/14651858.CD007742.pub4-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1746-1561.1991.tb03246.x","article-title":"The common stye","volume":"61","author":"Olson","year":"1991","journal-title":"Journal of School Health"},{"issue":"5","key":"10.1002\/14651858.CD007742.pub4-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1755-3768.1983.tb01476.x","article-title":"Intralesional corticosteroid injection for the treatment of chalazia","volume":"61","author":"Palva","year":"1983","journal-title":"Acta Ophthalmologica"},{"issue":"6","key":"10.1002\/14651858.CD007742.pub4-BIB0048|cit48","first-page":"721","article-title":"Current pattern treatment of hordeolum by ophthalmologists in Thailand","volume":"94","author":"Panicharoen","year":"2011","journal-title":"Journal of the Medical Association of Thailand"},{"issue":"1","key":"10.1002\/14651858.CD007742.pub4-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.iac.2007.12.004","article-title":"Dermatologic and allergic conditions of the eyelid","volume":"28","author":"Peralejo","year":"2008","journal-title":"Immunology and Allergy Clinics of North America"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0050|cit50","unstructured":"Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"4900","key":"10.1002\/14651858.CD007742.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1136\/bmj.2.4900.1322","article-title":"Staphylococcal infections in general practice","volume":"2","author":"Roodyn","year":"1954","journal-title":"British Medical Journal"},{"issue":"3","key":"10.1002\/14651858.CD007742.pub4-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0733-8627(20)30610-6","article-title":"Lids, lacrimals, and lashes","volume":"13","author":"Rubin","year":"1995","journal-title":"Emergency Medicine Clinics of North America"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0002-9394(42)92084-1","article-title":"The role of the meibomian glands in recurrent conjunctivitis","volume":"25","author":"Scobee","year":"1942","journal-title":"American Journal of Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD007742.pub4-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/0009922809333094","article-title":"The red eye: evaluation and management","volume":"48","author":"Sethuraman","year":"2009","journal-title":"Clinical Pediatrics"},{"key":"10.1002\/14651858.CD007742.pub4-BIB0055|cit55","unstructured":"Skorin L Hordeolum and chalazion treatment: the full gamut Optometry Today 2002 25 7"},{"issue":"9","key":"10.1002\/14651858.CD007742.pub4-BIB0056|cit56","first-page":"312","article-title":"Periorbital and orbital infections","volume":"25","author":"Wald","year":"2004","journal-title":"Infectious Disease Clinics of North America"},{"issue":"1053","key":"10.1002\/14651858.CD007742.pub4-BIB0057|cit57","first-page":"318","article-title":"Styes","volume":"176","author":"Wilkie","year":"1956","journal-title":"Practitioner"},{"issue":"9","key":"10.1002\/14651858.CD007742.pub4-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007742.pub2","article-title":"Interventions for acute internal hordeolum","author":"Lindsley","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD007742.pub4-BIB0059|cit59","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007742.pub3","article-title":"Interventions for acute internal hordeolum","author":"Lindsley","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD007742.pub4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:31:55Z","timestamp":1782106315000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007742.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Eyes and Vision Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,9]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007742.pub4","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,9]]}}}