{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:15:57Z","timestamp":1789917357433,"version":"4.0.1"},"publisher-location":"Chichester, UK","reference-count":37,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd007890.pub2","type":"reference-entry","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T09:38:20Z","timestamp":1369733900000},"source":"Crossref","is-referenced-by-count":7,"title":["Beta-blockers for preventing stroke recurrence"],"prefix":"10.1002","author":[{"given":"Luiz Gustavo","family":"De Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo GO","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Saconato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro N","family":"Atallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina MK","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,31]]},"reference":[{"key":"10.1002\/14651858.CD007890.pub2-BIB1|cit1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/01.STR.24.4.543","article-title":"Trial of secondary prevention with atenolol after transient ischemic attack or nondisabling ischemic stroke","volume":"24","year":"1993","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD007890.pub2-BIB2|cit2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000107813","article-title":"Atenolol in secondary prevention after stroke","volume":"5","author":"Eriksson","year":"1995","journal-title":"Cerebrovascular Diseases"},{"key":"10.1002\/14651858.CD007890.pub2-BIB3|cit3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/sj.jhh.1000446","article-title":"Effects of antihypertensive agents on circadian blood pressure in hypertensive patients with previous brain infarction","volume":"11","author":"Azuma","year":"1997","journal-title":"Journal of Human Hypertension"},{"key":"10.1002\/14651858.CD007890.pub2-BIB4|cit4","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1001\/jama.289.16.2073","article-title":"Principal results of the Controlled ONset Verapamil INvestigation of Cardiovascular End points (CONVINCE) trial","volume":"289","author":"Black","year":"2003","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD007890.pub2-BIB5|cit5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/bmj.293.6555.1145","article-title":"Randomized trial of treatment of hypertension in elderly patients in primary care","volume":"293","author":"Coope","year":"1986","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007890.pub2-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/0140-6736(91)92589-T","article-title":"Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension)","volume":"338","author":"Dahl\u00f6f","year":"1991","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB7|cit7","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","article-title":"Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol","volume":"359","author":"Dahl\u00f6f","year":"2002","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB8|cit8","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(05)67185-1","article-title":"Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomized controlled trial","volume":"366","author":"Dahl\u00f6f","year":"2005","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB9|cit9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0140-6736(98)05012-0","article-title":"Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomized trial","volume":"353","author":"Hansson","year":"1999","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/S0140-6736(99)10327-1","article-title":"Randomized trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity: the Swedish Trial in Old Patients with Hypertension-2 study","volume":"354","author":"Hansson","year":"1999","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB11|cit11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0140-6736(00)02526-5","article-title":"Randomized trial of effects of calcium antagonists compared with diuretics and \u03b2-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study","volume":"356","author":"Hansson","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB12|cit12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/01.STR.18.1.240","article-title":"Beta-adrenergic blockade after stroke: a preliminary closed cohort study","volume":"18","author":"Kinnander","year":"1987","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD007890.pub2-BIB13|cit13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/bmj.291.6488.97","article-title":"MRC trial of treatment of mild hypertension: principal results","volume":"291","year":"1985","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007890.pub2-BIB14|cit14","first-page":"405","article-title":"Medical Research Council trial of treatment of hypertension in older adults: principal results","volume":"304","year":"1982","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007890.pub2-BIB15|cit15","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1001\/jama.1991.03460240051027","article-title":"Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP)","volume":"265","year":"1991","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD007890.pub2-BIB16|cit16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00004872-198710000-00009","article-title":"Beta-blockers versus diuretics in hypertensive men: main results from the HAPPHY trial","volume":"5","author":"Wilhelmsen","year":"1987","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD007890.pub2-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(03)14739-3","article-title":"Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomized trials","volume":"362","year":"2003","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB18|cit18","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00004872-200304000-00001","article-title":"International Society of Hypertension (ISH): statement on blood pressure lowering and stroke prevention","volume":"21","author":"Chalmers","year":"2003","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD007890.pub2-BIB19|cit19","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0140-6736(90)90944-Z","article-title":"Blood pressure, stroke, and coronary heart disease. Part 2, short-term reductions in blood pressure: overview of randomized drug trials in their epidemiological context","volume":"335","author":"Collins","year":"1990","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB20|cit20","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1161\/01.STR.0000133129.58126.67","article-title":"Underestimation of the early risk of recurrent stroke - evidence of the need for a standard definition","volume":"35","author":"Coull","year":"2004","journal-title":"Stroke"},{"issue":"2","key":"10.1002\/14651858.CD007890.pub2-BIB21|cit21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.amjhyper.2005.08.007","article-title":"Atenolol and eprosartan: differential effects on central blood pressure and aortic pulse wave velocity","volume":"19","author":"Dhakam","year":"2006","journal-title":"American Journal of Hypertension"},{"key":"10.1002\/14651858.CD007890.pub2-BIB22|cit22","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1161\/01.STR.28.12.2557","article-title":"Effect of antihypertensive treatment in patients having already suffered from stroke. Gathering the evidence. The INDANA (INdividual Data ANalysis of Antihypertensive intervention trials) Project Collaborators","volume":"12","author":"Gueyffier","year":"1997","journal-title":"Stroke"},{"issue":"12","key":"10.1002\/14651858.CD007890.pub2-BIB23|cit23","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/01.STR.29.12.2491","article-title":"Long-term risk of first recurrent stroke in the Perth Community Stroke Study","volume":"29","author":"Hankey","year":"1998","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD007890.pub2-BIB24|cit24","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration Available from www.cochrane-handbook.org"},{"issue":"9426","key":"10.1002\/14651858.CD007890.pub2-BIB25|cit25","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/S0140-6736(04)16451-9","article-title":"Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial","volume":"363","author":"Julius","year":"2004","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB26|cit26","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(08)60655-8","article-title":"Global burden of blood-pressure-related disease, 2001","volume":"371","author":"Lawes","year":"2008","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(05)67573-3","article-title":"Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis","volume":"366","author":"Lindholm","year":"2005","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB28|cit28","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0140-6736(90)90878-9","article-title":"Blood pressure, stroke and coronary heart\u00a0 disease. Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias","volume":"335","author":"MacMahon","year":"1990","journal-title":"Lancet"},{"issue":"20","key":"10.1002\/14651858.CD007890.pub2-BIB29|cit29","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1161\/CIRCULATIONAHA.107.695007","article-title":"Risk\/benefit assessment of beta-blockers and diuretics precludes their use for first-line therapy in hypertension","volume":"117","author":"Messerli","year":"2008","journal-title":"Circulation"},{"issue":"9287","key":"10.1002\/14651858.CD007890.pub2-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(01)06178-5","article-title":"Randomised trial of a perindopril-based blood-pressure lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack","volume":"358","year":"2001","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007890.pub2-BIB31|cit31","unstructured":"The Nordic Cochrane Centre. The Cochrane Collaboration Review Manager (RevMan) 2011"},{"key":"10.1002\/14651858.CD007890.pub2-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1161\/01.STR.28.7.1507","article-title":"American Heart Association Prevention Conference: IV: prevention and rehabilitation of stroke: risk factors","volume":"28","author":"Sacco","year":"1997","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD007890.pub2-BIB33|cit33","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/01.STR.0000199147.30016.74","article-title":"Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association\/American Stroke Association Council on Stroke: cosponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline","volume":"37","author":"Sacco","year":"2006","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD007890.pub2-BIB34|cit34","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0149-2918(00)80041-7","article-title":"Aspirin plus extended-release dipyridamole or clopidogrel compared with aspirin monotherapy for the prevention of recurrent ischemic stroke: a cost effectiveness analysis","volume":"22","author":"Shah","year":"2000","journal-title":"Clinical Therapy"},{"key":"10.1002\/14651858.CD007890.pub2-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1161\/hc3801.097475","article-title":"American Heart Association\/American College of Cardiology guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology","volume":"104","author":"Smith","year":"2001","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD007890.pub2-BIB36|cit36","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1474-4422(07)70031-5","article-title":"Preventing stroke: saving lives around the world","volume":"6","author":"Strong","year":"2007","journal-title":"Lancet Neurology"},{"issue":"1","key":"10.1002\/14651858.CD007890.pub2-BIB37|cit37","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002003.pub2","article-title":"Beta-blockers for hypertension","author":"Wiysonge","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd007890.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD007890.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T18:14:52Z","timestamp":1628532892000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD007890.pub2"}},"subtitle":[],"editor":[{"given":"Edina MK","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,31]]},"references-count":37,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007890.pub2","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD007890.pub3","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[2013,5,31]]}}}