{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:34:32Z","timestamp":1793975672526,"version":"4.8.0"},"update-to":[{"DOI":"10.1002\/14651858.cd007950.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000}}],"reference-count":245,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007950.pub3","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T16:10:13Z","timestamp":1450109413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":238,"title":["Effects and safety of periconceptional oral folate supplementation for preventing birth defects"],"prefix":"10.1002","volume":"2015","author":[{"given":"Luz Maria","family":"De-Regil","sequence":"first","affiliation":[{"name":"Micronutrient Initiative; Research and Evaluation; 180 Elgin Street, Suite 1000 Ottawa ON Canada K2P 2K3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Pe\u00f1a-Rosas","sequence":"additional","affiliation":[{"name":"World Health Organization; Evidence and Programme Guidance, Department of Nutrition for Health and Development; 20 Avenue Appia Geneva Switzerland 1211"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C","family":"Fern\u00e1ndez-Gaxiola","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud P\u00fablica; Av. Universidad No. 655 Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pura","family":"Rayco-Solon","sequence":"additional","affiliation":[{"name":"World Health Organization; Evidence and Programme Guidance, Department of Nutrition for Health and Development; 20 Avenue Appia Geneva Switzerland 1211"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"10.1002\/14651858.CD007950.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1001\/jama.1989.03430120083026","article-title":"Randomized trial of periconceptional vitamins","volume":"262","author":"Czeizel","year":"1989","journal-title":"JAMA"},{"issue":"8393","key":"10.1002\/14651858.CD007950.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(84)92021-X","article-title":"Trial to prevent first occurrence of neural tube defects by periconceptional multivitamin supplementation","volume":"2","author":"Czeizel","year":"1984","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0013|cit3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1749-6632.1993.tb26128.x","article-title":"Controlled studies of multivitamin supplementation on pregnancy outcomes","volume":"678","author":"Czeizel","year":"1993","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"8954","key":"10.1002\/14651858.CD007950.pub3-BIB0014|cit4","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0140-6736(95)90052-7","article-title":"Limb-reduction defects and folic acid supplementation","volume":"345","author":"Czeizel","year":"1995","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0015|cit5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00001703-199504000-00003","article-title":"Nutritional supplementation and prevention of congenital abnormalities","volume":"7","author":"Czeizel","year":"1995","journal-title":"Current Opinion in Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0016|cit6","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1136\/bmj.306.6893.1645","article-title":"Prevention of congenital abnormalities by periconceptional multivitamin supplementation","volume":"306","author":"Czeizel","year":"1993","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0017|cit7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1096-8628(19960315)62:2<179::AID-AJMG12>3.0.CO;2-L","article-title":"Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation","volume":"62","author":"Czeizel","year":"1996","journal-title":"American Journal of Medical Genetics"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0003|cit8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/adc.70.3.229","article-title":"Postnatal somatic and mental development after periconceptional multivitamin supplementation","volume":"70","author":"Czeizel","year":"1994","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0006|cit9","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation","volume":"327","author":"Czeizel","year":"1992","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0004|cit10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF02718384","article-title":"The effect of periconceptional multivitamin-mineral supplementation on vertigo, nausea and vomiting in the first trimester of pregnancy","volume":"251","author":"Czeizel","year":"1992","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0005|cit11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02390940","article-title":"Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation","volume":"255","author":"Czeizel","year":"1994","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0007|cit12","first-page":"1255","article-title":"Periconceptional multivitamin supplementation and multimalformed offspring","volume":"102","author":"Czeizel","year":"2003","journal-title":"Obstetrics & Gynecology"},{"issue":"23","key":"10.1002\/14651858.CD007950.pub3-BIB0008|cit13","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1056\/NEJM199406093302314","article-title":"Higher rate of multiple births after periconceptional vitamin supplementation","volume":"330","author":"Czeizel","year":"1994","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0009|cit14","first-page":"55","article-title":"The effect of preconceptional multivitamin supplementation on fertility","volume":"66","author":"Czeizel","year":"1996","journal-title":"International Journal for Vitamin and Nutrition Research"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0010|cit15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/S0001566000001938","article-title":"The higher rate of multiple births after periconceptional multivitamin supplementation: an analysis of causes","volume":"43","author":"Czeizel","year":"1994","journal-title":"Acta Geneticae Medicae et Gemellologiae"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0011|cit16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1471-0528.1996.tb09808.x","article-title":"No change in sexual activity during preconceptional multivitamin supplementation","volume":"103","author":"Czeizel","year":"1996","journal-title":"British Journal of Obstetrics and Gynaecology"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0012|cit17","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.ajog.2004.02.018","article-title":"Periconceptional folic acid\/multivitamin supplementation and twin pregnancy","volume":"191","author":"Czeizel","year":"2004","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"42","key":"10.1002\/14651858.CD007950.pub3-BIB0018|cit18","first-page":"2313","article-title":"Prevention of the first occurrence of anencephaly and spina bifida with periconceptional multivitamin supplementation (conclusion)","volume":"135","author":"Czeizel","year":"1994","journal-title":"Orvosi Hetilap"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s004310050922","article-title":"Long-term somatic and mental development of children after periconceptional multivitamin supplementation","volume":"157","author":"Dobo","year":"1998","journal-title":"European Journal of Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01314639","article-title":"The effect of preconceptional multivitamin supplementation on the menstrual cycle","volume":"256","author":"Dudas","year":"1995","journal-title":"Archives of Gynecology and Obstetrics"},{"issue":"43","key":"10.1002\/14651858.CD007950.pub3-BIB0021|cit21","first-page":"2401","article-title":"Higher rate of multiple births after periconceptual multivitamin supplementation","volume":"137","author":"Metneki","year":"1996","journal-title":"Orvosi Hetilap"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0022|cit22","first-page":"206","article-title":"Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects from India","volume":"112","author":"Central Technical Co-ordinating","year":"2000","journal-title":"Indian Journal of Medical Research"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1136\/adc.67.12.1442","article-title":"A randomized trial of low dose folic acid to prevent neural tube defects","volume":"67","author":"Kirke","year":"1992","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0027|cit24","first-page":"383","article-title":"Prevention of neural tube defects by improvement in maternal diet and preconceptional folic acid supplementation","volume":"163","author":"Laurence","year":"1985","journal-title":"Progress in Clinical and Biological Research"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0028|cit25","first-page":"646","article-title":"The role of maternal nutrition and folic acid therapy before conception to prevent neural tube defects","volume":"130","author":"Laurence","year":"1982","journal-title":"Monatsschrift fur Kinderheilkunde"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0024|cit26","first-page":"85","article-title":"The role of improvement in the maternal diet and preconceptional folic acid supplementation in the prevention of neural tube defects","volume-title":"Prevention of spina bifida and other neural tube defects","author":"Laurence","year":"1983"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0025|cit27","first-page":"66","article-title":"A double randomised controlled trial for preconceptional folic acid supplementation for the prevention of recurrence of neural tube defects in high risk pregnancies","volume":"19","author":"Laurence","year":"1982","journal-title":"Journal of Medical Genetics"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0026|cit28","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1136\/bmj.282.6275.1509","article-title":"Double blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural tube defects","volume":"282","author":"Laurence","year":"1981","journal-title":"BMJ (Clinical Research Edition)"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007950.pub3-BIB0029|cit29","first-page":"22","article-title":"Folate supplements prevent recurrence of neural tube defects","volume":"50","author":"Anon","year":"1992","journal-title":"Nutrition Review"},{"issue":"8760","key":"10.1002\/14651858.CD007950.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group","volume":"338","author":"Anon","year":"1991","journal-title":"Lancet"},{"issue":"12","key":"10.1002\/14651858.CD007950.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1301\/nr.2005.dec.S116-S125","article-title":"Government-industry partnership in weekly iron-folic acid supplementation for women of reproductive age in the Philippines: impact on iron status","volume":"63","author":"Angeles-Adgeppa","year":"2005","journal-title":"Nutrition Reviews"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/ajcn\/60.2.286","article-title":"Evaluation of effectiveness of iron-folate supplementation and anthelminthic therapy against anemia in pregnancy - a study in the plantation sector of Sri Lanka","volume":"60","author":"Atukorala","year":"1994","journal-title":"American Journal of Clinical Nutrition"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1213S","DOI":"10.1093\/ajcn\/81.5.1213","article-title":"Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage","volume":"81","author":"Bailey","year":"2005","journal-title":"American Journal of Clinical Nutrition"},{"issue":"12","key":"10.1002\/14651858.CD007950.pub3-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1301\/nr.2005.dec.S95-S108","article-title":"Community mobilization and social marketing to promote weekly iron-folic acid supplementation in women of reproductive age in Vietnam: impact on anemia and iron status","volume":"63","author":"Berger","year":"2005","journal-title":"Nutrition Reviews"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0035|cit35","first-page":"335","article-title":"Which mothers take folic acid and folate containing foods?","volume":"15","author":"Binns","year":"2006","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1017\/S1368980007796295","article-title":"Awareness and consumption of folate-fortified foods by women of childbearing age in Western Australia","volume":"10","author":"Oddy","year":"2007","journal-title":"Public Health Nutrition"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0037|cit37","unstructured":"Blom F A randomized controlled trial on the effects of periconceptional and prenatal folic acid supplementation on congenital anomalies and preterm birth Netherlands Trial Register (http:\/\/www.trialsregister.nl) [accessed 30 July 2015] 2011"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0039|cit38","unstructured":"Bortolus R Randomized clinical trial to evaluate the efficacy of high dose of folic acid to prevent the occurrence of congenital malformations International Clinical Trials Registry Platform (accessed 2 Aug 2011) http:\/\/clinicaltrials.gov\/show\/NCT01244347 2009"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0038|cit39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1471-2393-14-166","article-title":"Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands","volume":"14","author":"Bortolus","year":"2014","journal-title":"BMC Pregnancy and Childbirth"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0040|cit40","unstructured":"Italian Medicines Agency Efficacy of folic acid at high doses in preventing congenital anomalies. Randomized clinical trial in fertile women who plan a pregnancy: folic acid 4 mg vs 0.4 mg https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/trial\/2008-004334-25\/IT#C (accessed 12 August 2015)"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/bdra.20307","article-title":"Trends of selected malformations in relation to folic acid recommendations and fortification: an international assessment","volume":"76","author":"Botto","year":"2006","journal-title":"Birth Defects Research"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/bdra.20210","article-title":"Changes in the birth prevalence of selected birth defects after grain fortification with folic acid in the United States: findings from a multi-state population-based study","volume":"73","author":"Canfield","year":"2005","journal-title":"Birth Defects Research"},{"issue":"12","key":"10.1002\/14651858.CD007950.pub3-BIB0043|cit43","first-page":"S152","article-title":"Weekly iron-folic acid supplementation of women of reproductive age: impact overview, lessons learned, expansion plans, and contributions toward achievement of the Millennium Development Goals","volume":"63","author":"Cavalli-Sforza","year":"2005","journal-title":"Nutrition Reviews"},{"issue":"8","key":"10.1002\/14651858.CD007950.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/bdra.20471","article-title":"Prevention of NTDs with periconceptional multivitamin supplementation containing folic acid in China","volume":"82","author":"Chen","year":"2008","journal-title":"Birth Defects Research"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0053|cit45","unstructured":"Christian P Personal communication"},{"issue":"8","key":"10.1002\/14651858.CD007950.pub3-BIB0045|cit46","first-page":"660","article-title":"The effect of maternal micronutrient supplementation on early neonatal morbidity in rural Nepal: a randomised, controlled, community trial","volume":"93","author":"Christian","year":"2008","journal-title":"Archives of Disease in Childhood"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0046|cit47","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ajcn\/83.4.788","article-title":"Antenatal supplementation with micronutrients and biochemical indicators of status and subclinical infection in rural Nepal","volume":"83","author":"Christian","year":"2006","journal-title":"American Journal of Clinical Nutrition"},{"issue":"7389","key":"10.1002\/14651858.CD007950.pub3-BIB0047|cit48","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/bmj.326.7389.571","article-title":"Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal: double blind randomised community trial","volume":"326","author":"Christian","year":"2003","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0048|cit49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijgo.2009.03.040","article-title":"Effects of prenatal micronutrient supplementation on complications of labor and delivery and puerperal morbidity in rural Nepal","volume":"106","author":"Christian","year":"2009","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"24","key":"10.1002\/14651858.CD007950.pub3-BIB0049|cit50","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1001\/jama.2010.1861","article-title":"Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal","volume":"304","author":"Christian","year":"2010","journal-title":"JAMA"},{"issue":"11","key":"10.1002\/14651858.CD007950.pub3-BIB0050|cit51","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1093\/jn\/133.11.3492","article-title":"Supplementation with micronutrients in addition to iron and folic acid does not further improve the hematologic status of pregnant women in rural Nepal","volume":"133","author":"Christian","year":"2003","journal-title":"Journal of Nutrition"},{"issue":"9","key":"10.1002\/14651858.CD007950.pub3-BIB0051|cit52","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/aje\/kwp253","article-title":"Antenatal and postnatal iron supplementation and childhood mortality in rural Nepal: a prospective follow-up in a randomized, controlled community trial","volume":"170","author":"Christian","year":"2009","journal-title":"American Journal of Epidemiology"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0052|cit53","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/ajcn\/78.6.1194","article-title":"Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal","volume":"78","author":"Christian","year":"2003","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0054|cit54","unstructured":"Christian PS Darmstadt GL Wu L Khatry SK Leclerq SC Katz J The impact of maternal micronutrient supplementation on early neonatal morbidity in rural Nepal: a randomized, controlled, community trial Archives of Disease in Childhood. Fetal and Neonatal Edition (http:\/\/fn.bmj.com\/content\/early\/2007\/08\/03\/adc.2006.114009.full.pdf+html) (accessed August 2007) 10.1136\/adc.2006.114009"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/jn\/136.5.1389","article-title":"Treatment effects of maternal micronutrient supplementation vary by percentiles of the birth weight distribution in rural Nepal","volume":"136","author":"Katz","year":"2006","journal-title":"Journal of Nutrition"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1017\/S1368980009005862","article-title":"Determinants of compliance to antenatal micronutrient supplementation and women's perceptions of supplement use in rural Nepal","volume":"13","author":"Kulkarni","year":"2010","journal-title":"Public Health Nutrition"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3945\/ajcn.2008.27368","article-title":"Antenatal supplementation with folic acid + iron + zinc improves linear growth and reduces peripheral adiposity in school-age children in rural Nepal","volume":"90","author":"Stewart","year":"2009","journal-title":"American Journal of Clinical Nutrition"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3945\/jn.111.144717","article-title":"Low maternal vitamin B-12 status is associated with offspring insulin resistance regardless of antenatal micronutrient supplementation in rural Nepal","volume":"141","author":"Stewart","year":"2011","journal-title":"Journal of Nutrition"},{"issue":"8","key":"10.1002\/14651858.CD007950.pub3-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3945\/jn.109.106666","article-title":"Antenatal micronutrient supplementation reduces metabolic syndrome in 6- to 8-year-old children in rural Nepal","volume":"139","author":"Stewart","year":"2009","journal-title":"Journal of Nutrition"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1740-8709.2007.00097.x","article-title":"Preterm delivery but not intrauterine growth retardation is associated with young maternal age among primiparae in rural Nepal","volume":"3","author":"Stewart","year":"2007","journal-title":"Maternal & Child Nutrition"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0061|cit61","unstructured":"Daly SF Cahill E Turner MJ Can fortified milk raise folic acid levels in non pregnant women? 27th British Congress of Obstetrics and Gynaecology; 1995 July 4-7, Dublin, Ireland 1995 Abstract no: 456"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/S0140-6736(97)07247-4","article-title":"Minimum effective dose of folic acid for food fortification to prevent neural tube defects","volume":"350","author":"Daly","year":"1997","journal-title":"Lancet"},{"issue":"11","key":"10.1002\/14651858.CD007950.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/qjmed\/95.11.733","article-title":"Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age","volume":"95","author":"Daly","year":"2002","journal-title":"QJM"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1079\/BJN2001376","article-title":"Inter-pregnancy folate and iron status of women in an inner-city population","volume":"86","author":"Doyle","year":"2001","journal-title":"British Journal of Nutrition"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1212\/WNL.58.10.1572","article-title":"Symptoms of B12 deficiency can occur in women of child bearing age supplemented with folate","volume":"58","author":"Drazkowski","year":"2002","journal-title":"Neurology"},{"issue":"9519","key":"10.1002\/14651858.CD007950.pub3-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/S0140-6736(06)68582-6","article-title":"Folic acid: a public-health challenge","volume":"367","author":"Eichholzer","year":"2006","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1054\/midw.1999.0196","article-title":"Community attitudes to pregnancy, anaemia, iron and folate supplementation in urban and rural Lagos, south-western Nigeria","volume":"16","author":"Ejidokun","year":"2000","journal-title":"Midwifery"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.thromres.2004.04.006","article-title":"Effect of supplementation with folic acid throughout pregnancy on plasma homocysteine concentration","volume":"114","author":"Ellison","year":"2004","journal-title":"Thrombosis Research"},{"issue":"3-4","key":"10.1002\/14651858.CD007950.pub3-BIB0070|cit70","first-page":"157","article-title":"Homocysteine and human reproduction","volume":"27","author":"Eskes","year":"2000","journal-title":"Clinical and Experimental Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0071|cit71","first-page":"11","article-title":"Neural tube defects. The role of vitamin supplementation in their prevention","volume":"32","author":"Field","year":"1991","journal-title":"Current Therapeutics"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00005237-200310000-00005","article-title":"Folic acid and neural tube defects in pregnancy: a review","volume":"17","author":"Geisel","year":"2003","journal-title":"Journal of Perinatal and Neonatal Nursing"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0073|cit73","doi-asserted-by":"crossref","unstructured":"Gunaratna NS Masanja H Mrema S Levira F Spiegelman D Hertzmark E Multivitamin and iron supplementation to prevent periconceptional anemia in rural Tanzanian women: A randomized, controlled trial PLoS ONE 2015 e0121552","DOI":"10.1371\/journal.pone.0121552"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1521-6934(03)00009-9","article-title":"Homocysteine and pregnancy","volume":"17","author":"Hague","year":"2003","journal-title":"Best Practice & Research in Clinical Obstetrics & Gynaecology"},{"issue":"12","key":"10.1002\/14651858.CD007950.pub3-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/oxfordjournals.aje.a008710","article-title":"Case-control study of periconceptional folic acid supplementation and oral clefts","volume":"143","author":"Hayes","year":"1996","journal-title":"American Journal of Epidemiology"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/1096-9926(200102)63:2<79::AID-TERA1013>3.0.CO;2-3","article-title":"Maternal multivitamin use and orofacial clefts in offspring","volume":"63","author":"Itikala","year":"2001","journal-title":"Teratology"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1203\/PDR.0b013e31815b8ec5","article-title":"Will increasing folic acid in fortified grain products further reduce neural tube defects without causing harm? Consideration of the evidence","volume":"63","author":"Johnston","year":"2008","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0080|cit78","volume-title":"Periconceptional Iron Supplementation and Iron and Folate Status Among Pregnant and Non-Pregnant Women in Rural Bangladesh [thesis]","author":"Khambalia","year":"2009"},{"issue":"Suppl","key":"10.1002\/14651858.CD007950.pub3-BIB0078|cit79","first-page":"Abstract no: 91","article-title":"Reduced anemia and improved iron and folate status before and after pregnancy among females in rural Bangladesh is related to length of adherence to periconceptional iron and folic acid supplementation","volume":"23","author":"Khambalia","year":"2014","journal-title":"Faseb Journal"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0079|cit80","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3945\/jn.108.101022","article-title":"Periconceptional iron and folate status is inadequate among married, nulliparous women in rural Bangladesh","volume":"139","author":"Khambalia","year":"2009","journal-title":"Journal of Nutrition"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3945\/ajcn.2009.28350","article-title":"Periconceptional iron supplementation does not reduce anemia or improve iron status among pregnant women in rural Bangladesh","volume":"90","author":"Khambalia","year":"2009","journal-title":"American Journal of Clinical Nutrition"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/ajcn\/82.4.843","article-title":"Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy","volume":"82","author":"Lee","year":"2005","journal-title":"American Journal of Clinical Nutrition"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0083|cit83","first-page":"567","article-title":"Effect of daily milk supplementation on serum and umbilical cord blood folic acid concentrations in pregnant Han and Mongolian women and birth characteristics in China","volume":"23","author":"Li","year":"2014","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"issue":"9","key":"10.1002\/14651858.CD007950.pub3-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/sj.ejcn.1600840","article-title":"A traditional beverage prevents iron deficiency in African women of child bearing age","volume":"53","author":"Mandishona","year":"1999","journal-title":"European Journal of Clinical Nutrition"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0085|cit85","first-page":"88","article-title":"Comparison study on the effect of prenatal administration of high dose and low dose folic acid","volume":"30","author":"Manizheh","year":"2009","journal-title":"Saudi Medical Journal"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0140-6736(05)74937-0","article-title":"Twinning and folic acid use","volume":"353","author":"Mathews","year":"1999","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3945\/ajcn.112.057489","article-title":"Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of folic acid supplementation in the second and third trimesters","volume":"98","author":"McNulty","year":"2013","journal-title":"American Journal of Clinical Nutrition"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007950.pub3-BIB0088|cit88","first-page":"82","article-title":"Prenatal administration of high dose and low dose folic acid on maternal plasma homocysteine concentration and its relationship to the development of preeclampsia","volume":"21","author":"Melli","year":"2008","journal-title":"Journal of Maternal-Fetal and Neonatal Medicine"},{"issue":"9","key":"10.1002\/14651858.CD007950.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/bdra.20390","article-title":"Australian survey on community knowledge and attitudes regarding the fortification of food with folic acid","volume":"79","author":"Molster","year":"2007","journal-title":"Birth Defects Research"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0090|cit90","first-page":"519","article-title":"Homocysteine and folate levels as risk factors for recurrent early pregnancy loss","volume":"95","author":"Nelen","year":"2000","journal-title":"Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0091|cit91","doi-asserted-by":"crossref","unstructured":"Gonzalez-Casanova I Nguyen P Harding K Reinhart G Nguyen H Truong T Predictors of adherence to preconception and prenatal micronutrient supplementation in Vietnam FASEB Journal 2015 [abstract no: 729.12]","DOI":"10.1096\/fasebj.29.1_supplement.729.12"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3945\/ajcn.2008.26878","article-title":"Steady state folate concentrations achieved with 5 compared with 1.1 mg folic acid supplementation among women of childbearing age","volume":"89","author":"Nguyen","year":"2009","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0093|cit93","doi-asserted-by":"crossref","unstructured":"Nguyen PH Lowe AE Martorell R Nguyen H Pham H Nguyen S Rationale, design, methodology and sample characteristics for the Vietnam pre-conceptual micronutrient supplementation trial (PRECONCEPT): a randomized controlled study BMC Public Health 2012 898","DOI":"10.1186\/1471-2458-12-898"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0094|cit94","unstructured":"Ramakrishnan U Impact of pre-pregnancy micronutrient supplementation on maternal and child outcomes http:\/\/clinicaltrials.gov (accessed 20 September 2012) 2012"},{"issue":"1 Suppl","key":"10.1002\/14651858.CD007950.pub3-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"LB416","DOI":"10.1096\/fasebj.28.1_supplement.lb416","article-title":"Optimizing periconceptional folic acid supplementation: steady-state folate pharmacokinetics in pregnancy","volume":"28","author":"Shere","year":"2014","journal-title":"FASEB Journal"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/jcph.387","article-title":"Pregnancy-induced changes in the long-term pharmacokinetics of 1.1mg vs. 5mg folic acid: a randomized clinical trial","volume":"55","author":"Shere","year":"2015","journal-title":"Journal of Clinical Pharmacology"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0097|cit97","first-page":"e280","article-title":"Steady-state folate pharmacokinetics in pregnancy: A randomized clinical trial in pregnant women supplementing with 1.1mg vs. 5mg folic acid","volume":"21","author":"Shere","year":"2014","journal-title":"Journal of Population Therapeutics and Clinical Pharmacology"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"285S","DOI":"10.1093\/ajcn\/85.1.285S","article-title":"Folate and neural tube defects","volume":"85","author":"Pitkin","year":"2007","journal-title":"American Journal of Clinical Nutrition"},{"issue":"5 Pt 1","key":"10.1002\/14651858.CD007950.pub3-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/0002-9378(91)90365-X","article-title":"On reducing the frequency of severe abruptio placentae","volume":"165","author":"Pritchard","year":"1991","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1590\/S0036-36342009000400010","article-title":"Prenatal multiple micronutrient supplementation impact on biochemical indicators during pregnancy and postpartum","volume":"51","author":"Garcia-Guerra","year":"2009","journal-title":"Salud Publica de Mexico"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/156482650502600304","article-title":"Effect of prenatal multiple micronutrient supplements on maternal weight and skinfold changes: a randomized double-blind clinical trial in Mexico","volume":"26","author":"Ramakrishnan","year":"2005","journal-title":"Food & Nutrition Bulletin"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/ajcn\/77.3.720","article-title":"Multiple micronutrient supplementation during pregnancy does not lead to greater infant birth size than does iron-only supplementation: a randomised controlled trial in a semirural community in Mexico","volume":"77","author":"Ramakrishnan","year":"2003","journal-title":"American Journal of Clinical Nutrition"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/jn\/134.4.898","article-title":"Multiple micronutrient supplements during pregnancy do not reduce anemia or improve iron status compared to iron-only supplements in semirural Mexico","volume":"134","author":"Ramakrishnan","year":"2004","journal-title":"Journal of Nutrition"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/01.ede.0000257063.77411.e9","article-title":"Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population","volume":"18","author":"Ray","year":"2007","journal-title":"Epidemiology"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/qjmed\/hcn031","article-title":"High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification","volume":"101","author":"Ray","year":"2008","journal-title":"Qjm"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1542\/peds.2005-2784","article-title":"Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acid [erratum appears in Pediatrics. 2006 Dec;118(6):2608]","volume":"118","author":"Robbins","year":"2006","journal-title":"Pediatrics"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ajog.2004.10.620","article-title":"Randomized trial of a physician-based intervention to increase the use of folic acid supplements among women","volume":"192","author":"Robbins","year":"2005","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1748-0361.2006.00032.x","article-title":"Awareness and use of folic acid among women in the lower Mississippi Delta","volume":"22","author":"Robbins","year":"2006","journal-title":"Journal of Rural Health"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"105-10; discuss","DOI":"10.1016\/S0301-2115(99)00084-6","article-title":"The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part I","volume":"87","author":"Rolschau","year":"1999","journal-title":"European Journal of Obstetric & Gynecology and Reproductive Biology"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0301-2115(99)00085-8","article-title":"The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part II. Congenital anomalies A randomised study","volume":"87","author":"Ulrich","year":"1999","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"115-8; discussi","DOI":"10.1016\/S0301-2115(99)00086-X","article-title":"The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part III. Congenital anomalies. An observational study","volume":"87","author":"Ulrich","year":"1999","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"issue":"8","key":"10.1002\/14651858.CD007950.pub3-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1017\/S1368980008002255","article-title":"Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age","volume":"11","author":"Rosenthal","year":"2008","journal-title":"Public Health Nutrition"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/oxfordjournals.pubmed.a024639","article-title":"A survey of knowledge and use of folic acid among women of child-bearing age in Dublin","volume":"19","author":"Sayers","year":"1997","journal-title":"Journal of Public Health Medicine"},{"issue":"8857","key":"10.1002\/14651858.CD007950.pub3-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0140-6736(93)90991-O","article-title":"Fortified foods and folate intake in women of child-bearing age","volume":"341","author":"Schorah","year":"1993","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.amepre.2008.06.034","article-title":"Computerized counseling for folate knowledge and use: a randomized controlled trial","volume":"35","author":"Schwarz","year":"2008","journal-title":"American Journal of Preventive Medicine"},{"issue":"8972","key":"10.1002\/14651858.CD007950.pub3-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0140-6736(95)92778-6","article-title":"Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally","volume":"346","author":"Shaw","year":"1995","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/01.ede.0000208348.30012.35","article-title":"Maternal nutrient intakes and risk of orofacial clefts","volume":"17","author":"Shaw","year":"2006","journal-title":"Epidemiology"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1079\/PNS2002163","article-title":"Can supplements help meet the micronutrient needs of the developing world?","volume":"61","author":"Shrimpton","year":"2002","journal-title":"Proceedings of the Nutrition Society"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/301825","article-title":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?","volume":"62","author":"Put","year":"1998","journal-title":"American Journal of Human Genetics"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0120|cit120","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ypmed.2004.02.036","article-title":"Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate","volume":"39","author":"Rooij","year":"2004","journal-title":"Preventive Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJMp038186","article-title":"Folic acid and the prevention of neural-tube defects","volume":"350","author":"Wald","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0122|cit122","first-page":"469","article-title":"Maternal folate status and neural tube defects in Ireland: the need for a national food fortification program","volume":"100","author":"Walsh","year":"2007","journal-title":"Irish Medical Journal"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.1369-6513.2002.00155.x","article-title":"Consequences of surveying folate awareness","volume":"5","author":"Watson","year":"2002","journal-title":"Health Expectations"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0124|cit124","first-page":"6","article-title":"The epidemiology of folate and neural tube defects: a community intervention and ongoing issues","volume":"10","author":"Watson","year":"2003","journal-title":"Australasian Epidemiologist"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0126|cit125","first-page":"389","article-title":"The increasing knowledge of the role of periconceptional folate in Victorian women of child-bearing age: follow-up of a randomised community intervention trial","volume":"25","author":"Watson","year":"2001","journal-title":"Australian & New Zealand Journal of Public Health"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0125|cit126","unstructured":"Watson M Watson L Bell R Halliday J Burford N Brennecke S Increasing knowledge of the role of folate in women of child-bearing age in Victoria - a randomised trial 2nd Annual Congress of the Perinatal Society of Australia & New Zealand; 1998 March 30-April 4; Alice Springs, Australia 1998 114"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0127|cit127","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1369-6513.1999.00064.x","article-title":"A randomized community intervention trial to increase awareness and knowledge of the role of periconceptional folate in women of child-bearing age","volume":"2","author":"Watson","year":"1999","journal-title":"Health Expectations"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0128|cit128","unstructured":"Javois L Birth defects treatment and prevention program: oral cleft prevention program (ongoing trial) ClinicalTrials.gov (http:\/\/clinicaltrials.gov\/)"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1515\/jpm-2012-0173","article-title":"Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil","volume":"41","author":"Vila-Nova","year":"2013","journal-title":"Journal of Perinatal Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/ijerph10020590","article-title":"High dosage folic acid supplementation, oral cleft recurrence and fetal growth","volume":"10","author":"Wehby","year":"2013","journal-title":"International Journal of Environmental Research and Public Health"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/1471-2431-12-184","article-title":"Oral cleft prevention program (OCPP)","volume":"12","author":"Wehby","year":"2012","journal-title":"BMC Pediatrics"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0132|cit132","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1701-2163(16)30166-9","article-title":"An exploration of health effects of folic acid in pregnancy beyond reducing neural tube defects","volume":"27","author":"Wen","year":"2005","journal-title":"Journal of Obstetrics & Gynaecology Canada: JOGC"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0134|cit133","first-page":"205","article-title":"Double-blind, placebo-controlled study of FertilityBlend: a nutritional supplement for improving fertility in women","volume":"33","author":"Westphal","year":"2006","journal-title":"Clinical and Experimental Obstetrics and Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0133|cit134","first-page":"289","article-title":"A nutritional supplement for improving fertility in women: a pilot study","volume":"49","author":"Westphal","year":"2004","journal-title":"Journal of Reproductive Medicine"},{"issue":"7591","key":"10.1002\/14651858.CD007950.pub3-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/bmj.39079.618287.0B","article-title":"Folic acid supplements and risk of facial clefts: national population based case-control study","volume":"334","author":"Wilcox","year":"2007","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"e685","DOI":"10.1542\/peds.2008-3007","article-title":"Effects of maternal multimicronutrient supplementation on the mental development of infants in rural western China: follow-up evaluation of a double-blind, randomized, controlled trial","volume":"123","author":"Li","year":"2009","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"a2001","DOI":"10.1136\/bmj.a2001","article-title":"Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial","volume":"337","author":"Zeng","year":"2008","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0138|cit138","unstructured":"Bailey LB Folic acid supplementation in pregnant women: dose response (FAPREG) ClinicalTrials.gov (http:\/\/clinicaltrials.gov\/) [accessed 27 September 2014] 2014"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0139|cit139","unstructured":"Hekmatdoost A Comparison of the effect of folic acid and 5-methyltetrahydrofolate (5MTHF) on serum folate and homocysteine levels, and abortion rates in women suffering from recurrent abortion IRCT Iranian Registry of Clinical Trials (www.irct.ir)"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0140|cit140","unstructured":"Koren G Optimizing periconceptional and prenatal folic acid supplementation ISRCTN Registry (http:\/\/www.isrctn.com\/) (accessed 9 September 2015)"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0141|cit141","unstructured":"Linet M Follow-up study of late effects of periconceptional folic acid in mothers and offspring in the community intervention program population: the Chinese children and families study http:\/\/clinicaltrials.gov\/show\/NCT01365975 (accessed 5 December 2013)"},{"issue":"7","key":"10.1002\/14651858.CD007950.pub3-BIB0142|cit142","doi-asserted-by":"crossref","first-page":"1636S","DOI":"10.3945\/jn.114.206599","article-title":"Biomarkers of nutrition for development-folate review","volume":"145","author":"Bailey","year":"2015","journal-title":"Journal of Nutrition"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jclinepi.2010.07.015","article-title":"GRADE guidelines: Rating the quality of evidence","volume":"64","author":"Balshem","year":"2011","journal-title":"Journal of Clinical \u00a0Epidemiology"},{"issue":"20","key":"10.1002\/14651858.CD007950.pub3-BIB0144|cit144","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1056\/NEJM199911113412001","article-title":"Prevention of neural-tube defects with folic acid in China. China-U.S. collaborative project for neural tube defect prevention","volume":"341","author":"Berry","year":"1999","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0145|cit145","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/bmj.38369.437789.82","article-title":"Impact of misclassification of in vitro fertilisation in studies of folic acid and twinning: modelling using population based Swedish vital records","volume":"330","author":"Berry","year":"2004","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0146|cit146","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.earlhumdev.2005.03.003","article-title":"Folic acid supplementation is not associated with an increase in dizygotic twinning","volume":"81","author":"Berry","year":"2005","journal-title":"Early Human Development"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007950.pub3-BIB0147|cit147","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1177\/15648265100311S103","article-title":"Folic Acid Working Group. Fortification of flour with folic acid","volume":"31","author":"Berry","year":"2010","journal-title":"Food Nutrition Bulletin"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007950.pub3-BIB0148|cit148","first-page":"10","article-title":"Folic acid to reduce neonatal mortality from neural tube disorders","volume":"Apr;39","author":"Blencowe","year":"2010","journal-title":"International Journal of Epidemiology"},{"issue":"9","key":"10.1002\/14651858.CD007950.pub3-BIB0149|cit149","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/oxfordjournals.aje.a010290","article-title":"5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review","volume":"151","author":"Botto","year":"2000","journal-title":"American Journal of Epidemiology"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0150|cit150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/ajmg.c.30004","article-title":"Vitamin supplements and the risk for congenital anomalies other than neural tube defects","volume":"125C","author":"Botto","year":"2004","journal-title":"American Journal of Medical Genetics Part C. Seminars in Medical Genetics"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0151|cit151","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/bmj.38336.664352.82","article-title":"International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working?","volume":"330","author":"Botto","year":"2005","journal-title":"BMJ"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0152|cit152","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/ajmg.a.32989","article-title":"Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syndrome and congenital heart defects","volume":"149A","author":"Brandalize","year":"2009","journal-title":"American Journal of Medical Genetics. Part A"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0153|cit153","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3945\/jn.112.169987","article-title":"Dietary supplement use and folate status during pregnancy in the United States","volume":"143","author":"Branum","year":"2013","journal-title":"Journal of Nutrition"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0154|cit154","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1024\/0300-9831.79.2.61","article-title":"Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women","volume":"79","author":"Br\u00e4mswig","year":"2009","journal-title":"International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0155|cit155","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4269\/ajtmh.2005.73.166","article-title":"Reduction of the efficacy of antifolate antimalarial therapy by folic acid supplementation","volume":"73","author":"Carter","year":"2005","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0156|cit156","volume-title":"National Report on Biochemical Indicators of Diet and Nutrition in the US Population 1999-2002. Water soluble vitamins and related biochemical compounds","author":"Centers for Disease Control and Prevention","year":"2008"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0157|cit157","first-page":"8","article-title":"Trends in wheat-flour fortification with folic acid and iron - worldwide, 2004 and 2007","volume":"57","author":"Centers for Disease Control and Prevention (CDC)","year":"2008","journal-title":"MMWR. Morbidity and Mortality Weekly Report"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0158|cit158","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/mgme.2000.3034","article-title":"A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia","volume":"70","author":"Chango","year":"2000","journal-title":"Molecular Genetics and Metabolism"},{"issue":"21","key":"10.1002\/14651858.CD007950.pub3-BIB0159|cit159","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1001\/jama.297.21.2351","article-title":"Folic acid for the prevention of colorectal adenomas: a randomized clinical trial","volume":"297","author":"Cole","year":"2007","journal-title":"JAMA"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0160|cit160","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mrrev.2009.06.001","article-title":"The complex relationship between folate\/homocysteine metabolism and risk of Down syndrome","volume":"682","author":"Coppede","year":"2009","journal-title":"Mutation Research"},{"issue":"26","key":"10.1002\/14651858.CD007950.pub3-BIB0161|cit161","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation","volume":"327","author":"Czeizel","year":"1992","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0162|cit162","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0301-2115(98)00246-2","article-title":"Ten years of experience in periconceptional care","volume":"84","author":"Czeizel","year":"1999","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0163|cit163","doi-asserted-by":"crossref","first-page":"50","DOI":"10.7150\/ijms.1.50","article-title":"The primary prevention of birth defects: multivitamins or folic acid?","volume":"1","author":"Czeizel","year":"2004","journal-title":"International Journal of Medical Sciences"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0164|cit164","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1753-4887.2009.00193.x","article-title":"Nutritional interpretation of folic acid interventions","volume":"67","author":"Dary","year":"2009","journal-title":"Nutrition Reviews"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0165|cit165","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1056\/NEJMoa067103","article-title":"Reduction in neural-tube defects after folic acid fortification in Canada","volume":"357","author":"Wals","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0166|cit166","doi-asserted-by":"crossref","first-page":"96\u2013106","DOI":"10.3945\/ajcn.113.062752","article-title":"Biomarker responses to folic acid intervention in healthy adults: A meta-analysis of randomized controlled trials","volume":"99","author":"Duffy","year":"2014","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0167|cit167","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2296-7-41","article-title":"Preconception counselling initiated by general practitioners in the Netherlands: reaching couples contemplating pregnancy [ISRCTN53942912]","volume":"7","author":"Elsinga","year":"2006","journal-title":"BMC Family Practice"},{"issue":"9505","key":"10.1002\/14651858.CD007950.pub3-BIB0168|cit168","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0140-6736(06)67939-7","article-title":"Iron and folic acid supplementation and malaria risk","volume":"367","author":"English","year":"2006","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0169|cit169","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1375\/1369052012155","article-title":"Use of multivitamins and folic acid in early pregnancy and multiple births in Sweden","volume":"4","author":"Ericson","year":"2001","journal-title":"Twin Research : the official journal of the International Society for Twin Studies"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0170|cit170","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejogrb.2005.07.028","article-title":"Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature","volume":"124","author":"Eskes","year":"2006","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"issue":"7","key":"10.1002\/14651858.CD007950.pub3-BIB0171|cit171","first-page":"3328","article-title":"Scientific Opinionon the substantiation of a health claim related to increasing maternal folate status by supplemental folate intake and reduced risk of neural tube defects pursuant to article 14 of regulation (EC) No 1924\/2006","volume":"11","author":"Nutrition","year":"2013","journal-title":"European Food Safety Authority Journal"},{"issue":"12","key":"10.1002\/14651858.CD007950.pub3-BIB0172|cit172","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009218.pub2","article-title":"Intermittent iron supplementation for reducing anaemia and its associated impairments in menstruating women","author":"Fern\u00e1ndez-Gaxiola","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0173|cit173","first-page":"Epub ahead of p","article-title":"Folic acid supplementation and colorectal cancer risk; a meta-analysis","volume":"Oct 27","author":"Fife","year":"2009","journal-title":"Colorectal Disease"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0174|cit174","first-page":"A5019","article-title":"Few Danish pregnant women follow guidelines on periconceptional use of folic acid","volume":"61","author":"Friberg","year":"2015","journal-title":"Danish Medical Journal"},{"issue":"9547","key":"10.1002\/14651858.CD007950.pub3-BIB0175|cit175","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/S0140-6736(06)69478-6","article-title":"Sexual and reproductive health: a matter of life and death","volume":"368","author":"Glasier","year":"2006","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0176|cit176","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S1701-2163(16)32227-7","article-title":"Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis","volume":"28","author":"Goh","year":"2006","journal-title":"Journal of Obstetrics and Gynaecology Canada: JOGC"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0177|cit177","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/sj.clpt.6100100","article-title":"Prenatal multivitamin supplementation and rates of pediatric cancer: a meta-analysis","volume":"81","author":"Goh","year":"2007","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0178|cit178","first-page":"1","article-title":"Folate and folic acid in the periconceptional period: recommendations from official health organizations in thirty-six countries worldwide and WHO","volume":"[Epub ahead of","author":"Gomes","journal-title":"Public Health Nutrition"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0179|cit179","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/ajcn.83.3.701","article-title":"Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations","volume":"83","author":"Gu\u00e9ant-Rodriguez","year":"2006","journal-title":"American Journal of Clinical Nutrition"},{"issue":"11","key":"10.1002\/14651858.CD007950.pub3-BIB0180|cit180","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004905.pub4","article-title":"Multiple-micronutrient supplementation for women during pregnancy","author":"Haider","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0181|cit181","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S0007114508149200","article-title":"Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid","volume":"102","author":"Heseker","year":"2009","journal-title":"British Journal of Nutrition"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0182|cit182","article-title":"Review Manager (RevMan)","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2011"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0183|cit183","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/ajcn\/83.4.842","article-title":"[6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation","volume":"83","author":"Houghton","year":"2006","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0184|cit184","first-page":"196","article-title":"Folate","volume-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline","author":"Institute of Medicine","year":"1998"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0185|cit185","volume-title":"Reducing birth defects: meeting the challenge in the developing world","author":"Bale","year":"2003"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0186|cit186","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0002-9378(75)90179-9","article-title":"Effect of folic acid supplement on birth weights of infants","volume":"122","author":"Iyengar","year":"1975","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"14","key":"10.1002\/14651858.CD007950.pub3-BIB0187|cit187","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.3748\/wjg.14.4492","article-title":"Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial","volume":"28","author":"Jaszewski","year":"2008","journal-title":"World Journal Gastroenterology"},{"issue":"9","key":"10.1002\/14651858.CD007950.pub3-BIB0188|cit188","first-page":"707","article-title":"Trends in twinning rates in metropolitan Atlanta before and after folic acid fortification","volume":"49","author":"Kucik","year":"2004","journal-title":"Journal of Reproductive Medicine"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0189|cit189","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/ajcn\/79.3.473","article-title":"Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women","volume":"79","author":"Lamers","year":"2004","journal-title":"American Journal of Clinical Nutrition"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0190|cit190","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006896.pub2","article-title":"Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes","author":"Lassi","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0191|cit191","volume-title":"Assessment of folate methodology used in the Third National Health and Nutrition Survey (NHANES 1988-1994)","author":"Life Sciences Research Office","year":"1994"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0192|cit192","doi-asserted-by":"crossref","first-page":"010402","DOI":"10.7189\/jogh.04.010402","article-title":"Estimating the burden of neural tube defects in low- and middle-income countries","volume":"4","author":"Lo","year":"2014","journal-title":"Journal of Global Health"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0193|cit193","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00404-006-0223-2","article-title":"Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia","volume":"275","author":"Makedos","year":"2007","journal-title":"Archives of Gynecology & Obstetrics"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0194|cit194","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.3390\/nu7042663","article-title":"Assessing the association between natural food folate intake and blood folate concentrations: a systematic review and Bayesian meta-analysis of trials and observational studies","volume":"7","author":"Marchetta","year":"2015","journal-title":"Nutrients"},{"issue":"7-8","key":"10.1002\/14651858.CD007950.pub3-BIB0195|cit195","first-page":"809","article-title":"The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot","volume":"28","author":"Marinho","year":"2009","journal-title":"Revista Portuguesa de Cardiologia"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0196|cit196","first-page":"103","article-title":"Impact of weekly administration of folic acid on folic acid blood levels","volume":"43","author":"Martinez-de Villareal","year":"2001","journal-title":"Salud Publica de Mexico"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0197|cit197","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/tera.10094","article-title":"Decline of neural tube defects cases after a folic acid campaign in Nuevo Le\u00f3n, M\u00e9xico","volume":"66","author":"Martinez-de Villareal","year":"2002","journal-title":"Teratology"},{"issue":"7","key":"10.1002\/14651858.CD007950.pub3-BIB0198|cit198","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1158\/1055-9965.EPI-07-0329","article-title":"A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis","volume":"16","author":"Mason","year":"2007","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0199|cit199","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1079\/PNS2004383","article-title":"Folate bioavailability","volume":"63","author":"McNulty","year":"2004","journal-title":"Proceedings of the Nutrition Society"},{"issue":"9062","key":"10.1002\/14651858.CD007950.pub3-BIB0200|cit200","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0140-6736(96)07494-6","article-title":"Regional patterns of disability-free life expectancy and disability-adjusted life expectancy: Global Burden of Disease Study","volume":"349","author":"Murray","year":"1997","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0201|cit201","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00436-008-0897-4","article-title":"Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer","volume":"102","author":"Nduati","year":"2008","journal-title":"Parasitology Research"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0202|cit202","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/sj.ejcn.1601843","article-title":"Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women","volume":"58","author":"Norsworthy","year":"2004","journal-title":"European Journal of Clinical Nutrition"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0203|cit203","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1161\/01.HYP.0000126580.81230.da","article-title":"Homocysteine and folic acid are inversely related in black women with preeclampsia","volume":"43","author":"Patrick","year":"2004","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0204|cit204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nyas.12434","article-title":"Technical considerations for maize flour and corn meal fortification in public health: consultation rationale and summary","volume":"1312","author":"Pe\u00f1a-Rosas","year":"2014","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"7","key":"10.1002\/14651858.CD007950.pub3-BIB0205|cit205","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004736.pub5","article-title":"Daily oral iron supplementation during pregnancy","author":"Pe\u00f1a-Rosas","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0206|cit206","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009997.pub2","article-title":"Intermittent oral iron supplementation during pregnancy","author":"Pe\u00f1a-Rosas","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0207|cit207","first-page":"156\u201374","article-title":"Biochemical indices","volume-title":"Enclyclopedia of Human Nutrition","author":"Pfeiffer","year":"2013"},{"issue":"8","key":"10.1002\/14651858.CD007950.pub3-BIB0208|cit208","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2165\/11532990-000000000-00000","article-title":"Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics","volume":"49","author":"Pietrzik","year":"2010","journal-title":"Clinical Pharmacokinetics"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0209|cit209","first-page":"154","article-title":"The impact of food fortification on folic acid intake in Canada","volume":"94","author":"Quinlivan","year":"2003","journal-title":"Canadian Journal of Public Health"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007950.pub3-BIB0210|cit210","first-page":"285\u2013301","article-title":"Effect of women's nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review","volume":"26","author":"Ramakrishnan","year":"2012","journal-title":"Paediatric and Perinatal Epidemiology"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0211|cit211","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/ajcn\/88.2.253","article-title":"Are we ready for mandatory fortification with vitamin B-12?","volume":"88","author":"Refsum","year":"2008","journal-title":"American Journal of Clinical Nutrition"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0212|cit212","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1079\/BJN20041395","article-title":"The influence of erythrocyte folate and serum vitamin B12 status on birth weight","volume":"93","author":"Relton","year":"2005","journal-title":"British Journal of Nutrition"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0213|cit213","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003094.pub3","article-title":"Treatments for iron-deficiency anaemia in pregnancy","author":"Reveiz","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0214|cit214","unstructured":"The Nordic Cochrane Centre Review Manager (RevMan). 5.3 2014"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0215|cit215","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1017\/S0007114509991954","article-title":"Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study","volume":"103","author":"Roza","year":"2010","journal-title":"British Journal of Nutrition"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0216|cit216","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1469-7610.2009.02182.x","article-title":"Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring","volume":"51","author":"Schlotz","year":"2010","journal-title":"Journal of Child Psychology and Psychiatry, and Allied Disciplines"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0217|cit217","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ajmg.a.20145","article-title":"Food fortification with folic acid and twinning among California infants","volume":"119A","author":"Shaw","year":"2003","journal-title":"American Journal of Medical Genetics. Part A"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0218|cit218","first-page":"463","article-title":"Congenital anomalies","volume-title":"Health Dimensions of Sex and Reproduction","author":"Shibuya","year":"1998"},{"issue":"4","key":"10.1002\/14651858.CD007950.pub3-BIB0219|cit219","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/01.AOG.0000154886.40318.5e","article-title":"Effects of folic acid fortification on twin gestation rates","volume":"105","author":"Signore","year":"2005","journal-title":"Obstetrics and Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0220|cit220","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3945\/ajcn.111.030791","article-title":"Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study","volume":"95","author":"Steenweg-de Graaff","year":"2012","journal-title":"American Journal of Clinical Nutrition"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0221|cit221","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ajcn\/83.5.993","article-title":"Folate and human reproduction","volume":"83","author":"Tamura","year":"2006","journal-title":"American Journal of Clinical Nutrition"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0222|cit222","doi-asserted-by":"crossref","first-page":"697S","DOI":"10.3945\/ajcn.2008.26947B","article-title":"Vitamin B12 and neural tube defects: the Canadian experience","volume":"89","author":"Thompson","year":"2009","journal-title":"American Journal of Clinical Nutrition"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0223|cit223","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011766","article-title":"Folate supplementation in women of reproductive age","author":"Tsang","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"9","key":"10.1002\/14651858.CD007950.pub3-BIB0224|cit224","doi-asserted-by":"crossref","first-page":"626","DOI":"10.7326\/0003-4819-150-9-200905050-00009","article-title":"Folic acid for the prevention of neural tube defects: US Preventive Services Task Force recommendation statement","volume":"150","author":"US Preventive Services Task Force","year":"2009","journal-title":"Annals of Internal Medicine"},{"issue":"8","key":"10.1002\/14651858.CD007950.pub3-BIB0225|cit225","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/eurheartj\/ehi815","article-title":"Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation","volume":"27","author":"Beynum","year":"2006","journal-title":"European Heart Journal"},{"issue":"5","key":"10.1002\/14651858.CD007950.pub3-BIB0226|cit226","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/301825","article-title":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?","volume":"62","author":"Put","year":"1998","journal-title":"American Journal of Human Genetics"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0227|cit227","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1086\/592715","article-title":"Plasma folate level and high-dose folate supplementation predict sulfadoxine-pyrimethamine treatment failure in pregnant women in Western Kenya who have uncomplicated malaria","volume":"198","author":"Eijk","year":"2008","journal-title":"Journal of Infectious Diseases"},{"issue":"11","key":"10.1002\/14651858.CD007950.pub3-BIB0228|cit228","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1093\/jn\/132.11.3353","article-title":"Increases in blood folate indices are similar in women of childbearing age supplemented with [6S]-5-methyltetrahydrofolate and folic acid","volume":"132","author":"Venn","year":"2002","journal-title":"Journal of Nutrition"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0229|cit229","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/ajcn\/77.3.658","article-title":"Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study","volume":"77","author":"Venn","year":"2003","journal-title":"American Journal of Clinical Nutrition"},{"issue":"2","key":"10.1002\/14651858.CD007950.pub3-BIB0230|cit230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.ede.0000152914.84962.13","article-title":"Folate supplementation and twin pregnancies","volume":"16","author":"Vollset","year":"2005","journal-title":"Epidemiology"},{"issue":"1","key":"10.1002\/14651858.CD007950.pub3-BIB0231|cit231","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1601-0825.2009.01587.x","article-title":"Folic acid and orofacial clefts: a review of the evidence","volume":"16","author":"Wehby","year":"2010","journal-title":"Oral Diseases"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0232|cit232","volume-title":"Human genetics: services for the prevention and management of genetic disorders and birth defects in developing countries. Report of a joint WHO\/WOAPBD Meeting","author":"World Health Organization","year":"1999"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0233|cit233","volume-title":"Primary health care approaches for the prevention and control of congenital genetic disorders. Report of a WHO meeting","author":"World Health Organization","year":"2000"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0234|cit234","unstructured":"World Health Organization Prevention of\u00a0neural tube defects. Standards for maternal and neonatal care www.who.int\/reproductive-health\/publications\/standards\/neural_tube_defects.pdf"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0235|cit235","unstructured":"World Health Organization Guideline Intermittent iron supplementation for menstruating women Geneva World Health Organization"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0236|cit236","volume-title":"Guideline: optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects","author":"World Health Organization","year":"2015"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0237|cit237","volume-title":"Serum and red blood cell folate concentrations for assessing folate status in populations","volume":"WHO\/NMH\/NHD\/EPG","author":"World Health Organization","year":"2015"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0238|cit238","article-title":"Congenital anomalies","volume-title":"Congenital anomalies. Fact sheet N\u00b0370","author":"World Health Organization","year":"2015"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0239|cit239","volume-title":"Birth defects surveillance: a manual for programme managers","author":"World Health Organization","year":"2014"},{"key":"10.1002\/14651858.CD007950.pub3-BIB0240|cit240","unstructured":"WHO UNICEF UNU Iron deficiency anaemia: assessment, prevention and control. A guide for programme managers Report from a the WHO\/UNICEF\/UNU consultation, 6-10 December 1993 Geneva World Health Organization 2001"},{"issue":"6","key":"10.1002\/14651858.CD007950.pub3-BIB0241|cit241","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.3945\/ajcn.2009.28319","article-title":"A randomized trial on folic acid supplementation and risk of recurrent colorectaladenoma","volume":"90","author":"Wu","journal-title":"American Journal of Clinical Nutrition."},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0242|cit242","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11154-008-9087-z","article-title":"Maternal nutrition, intrauterine programming and consequential risks in the offspring","volume":"9","author":"Yajnik","year":"2008","journal-title":"Reviews in Endocrine & Metabolic Disorders"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0243|cit243","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007950","article-title":"Effects and safety of periconceptional folate supplementation for preventing birth defects","author":"Regil","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"10","key":"10.1002\/14651858.CD007950.pub3-BIB0244|cit244","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007950.pub2","article-title":"Effects and safety of periconceptional folate supplementation for preventing birth defects","author":"De-Regil","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD007950.pub3-BIB0245|cit245","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001056","article-title":"Periconceptional supplementation with folate and\/or multivitamins for preventing neural tube defects","author":"Lumley","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD007950.pub3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T18:19:49Z","timestamp":1706811589000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007950.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Pregnancy and Childbirth Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,14]]},"references-count":245,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007950.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,14]]}}}