{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:37:11Z","timestamp":1785285431849,"version":"3.55.0"},"update-to":[{"DOI":"10.1002\/14651858.cd008121","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2010,12,8]],"date-time":"2010-12-08T00:00:00Z","timestamp":1291766400000}}],"reference-count":110,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008121.pub2","type":"journal-article","created":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T19:55:00Z","timestamp":1291060500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Second-generation antipsychotics for major depressive disorder and dysthymia"],"prefix":"10.1002","volume":"2012","author":[{"given":"Katja","family":"Komossa","sequence":"first","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; Moehlstrasse 26 M\u00fcnchen Germany 81675"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M","family":"Depping","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; Moehlstrasse 26 M\u00fcnchen Germany 81675"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gaudchau","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; Moehlstrasse 26 M\u00fcnchen Germany 81675"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Kissling","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; Moehlstrasse 26 M\u00fcnchen Germany 81675"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Leucht","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; Moehlstrasse 26 M\u00fcnchen Germany 81675"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,8]]},"reference":[{"key":"10.1002\/14651858.CD008121.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00004850-200111000-00001","article-title":"Faster response on amisulpride 50 mg versus sertraline 50-100 mg in patients with dysthymia or double depression: a randomized, double-blind, parallel group study","volume":"16","author":"Amore","year":"2001","journal-title":"International Clinical Psychopharmacology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0002|cit2","doi-asserted-by":"crossref","unstructured":"Bauer M Pretorius H Earley W Lindgren P Brecher M Results from a phase III study of extended release quetiapine fumarate (quetiapine XR) as add-on to antidepressants in patients with major depressive disorder (MDD) 7th International Forum on Mood and Anxiety Disorders 2007","DOI":"10.1016\/j.eurpsy.2008.01.463"},{"issue":"6","key":"10.1002\/14651858.CD008121.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"843","DOI":"10.4088\/JCP.v68n0604","article-title":"The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study","volume":"68","author":"Berman","year":"2007","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1017\/S1092852900020216","article-title":"Aripiprazole augmentation in major depressive disorder: a double-blind, placebo-controlled study in patients with inadequate response to antidepressants","volume":"14","author":"Berman","year":"2009","journal-title":"CNS Spectrums"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0006|cit5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0924-9338(96)85188-1","article-title":"Atypical antipsychotic drugs in dysthymia: placebo controlled studies of amisulpride versus imipramine, versus amineptine","volume":"11","author":"Boyer","year":"1996","journal-title":"European Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0005|cit6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000026556","article-title":"Amisulpride versus amineptine and placebo for the treatment of dysthymia","volume":"39","author":"Boyer","year":"1999","journal-title":"Neuropsychobiology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00004850-200201000-00004","article-title":"Efficacy and safety of amisulpride 50 mg versus paroxetine 20 mg in major depression: a randomized, double-blind, parallel group study","volume":"17","author":"Cassano","year":"2002","journal-title":"International Clinical Psychopharmacology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/da.20130","article-title":"A randomized, double-blind comparison of olanzapine\/fluoxetine combination, olanzapine, fluoxetine, and venlafaxine in treatment-resistant depression","volume":"23","author":"Corya","year":"2006","journal-title":"Depression and Anxiety"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0009|cit9","first-page":"242","article-title":"Treatment of dysthymic disorder with low-dose amisulpride","volume":"3","author":"Costa-E-Silva","year":"1990","journal-title":"Annales de Psychiatrie"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4088\/JCP.08m04592","article-title":"Extended release quetiapine fumarate monotherapy in major depressive disorder: a placebo- and duloxetine-controlled study","volume":"70","author":"Cutler","year":"2009","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0011|cit11","doi-asserted-by":"crossref","unstructured":"Montgomery S Cutler A Lazarus A Schollin M Brecher M A randomised, placebo-controlled study of once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy in patients with major depressive disorder (MDD) 7th International Forum on Mood and Anxiety Disorders 2007","DOI":"10.1016\/j.eurpsy.2008.01.518"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0012|cit12","doi-asserted-by":"crossref","unstructured":"Datto C Lam R Lepola U Sweitzer D Eriksson H Brecher M Double-blind study of extended release quetiapine fumarate (quetiapine XR) monotherapy for maintenance treatment of major depressive disorder (MDD) 161st Annual Meeting of the American Psychiatric Association 2008","DOI":"10.1016\/S0924-977X(08)70540-6"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0013|cit13","unstructured":"El-Khalili N Banov M Bortnick B Adson D Datto C Raines S Efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in major depressive disorder (MDD): a randomized, placebo-controlled clinical trial (Study 003) 63rd Annual Society of Biological Psychiatry 2008"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0014|cit14","unstructured":"El-Khalili N Joyce M Atkinson S Buynak R Datto C Lindgren P Adjunctive extended-release quetiapine fumarate (quetiapine XR) in patients with inadequate antidepressant response 161st Annual Meeting of the American Psychiatric Association 2008"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0015|cit15","unstructured":"Keitner GI Garlow S Ryan C Ninan P Solomon D Nemeroff C A randomized, placebo-controlled trial of risperidone augmentation for patients with difficult-to-treat unipolar, non-psychotic major depression 46th Annual New Clinical Drug Evaluation Unit Meeting 2006"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jpsychires.2008.05.003","article-title":"A randomized, placebo-controlled trial of risperidone augmentation for patients with difficult-to-treat unipolar, non-psychotic major depression","volume":"43","author":"Keitner","year":"2009","journal-title":"Journal of Psychiatric Research"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-0327(96)00103-6","article-title":"Amisulpride versus imipramine and placebo in dysthymia and major depression","volume":"43","author":"Lecrubier","year":"1997","journal-title":"Journal of Affective Disorders"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7326\/0003-4819-147-9-200711060-00003","article-title":"Risperidone for treatment - refractory major depressive disorder","volume":"147","author":"Mahmoud","year":"2007","journal-title":"Annals of Internal Medicine"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/JCP.0b013e31816774f9","article-title":"The efficacy and safety of arpiprazole as adjunctive therapy in major depressive disorder","volume":"28","author":"Marcus","year":"2008","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/da.20275","article-title":"Quetiapine adjunct to selective serotonin reuptake inhibitors or venlafaxine in patients with major depression, comorbid anxiety, and residual depressive symptoms: a randomized, placebo-controlled pilot study","volume":"24","author":"McIntyre","year":"2007","journal-title":"Depression and Anxiety"},{"issue":"1","key":"10.1002\/14651858.CD008121.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/JGP.0b013e31813546f2","article-title":"Placebo-controlled study of relapse prevention with risperidone augmentation in older patients with resistant depression","volume":"16","author":"Alexopoulos","year":"2008","journal-title":"American Journal of Geriatric Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD008121.pub2-BIB0022|cit22","first-page":"87","article-title":"Remission and maintenance effect of risperidone augmentation for older patients with resistant depression","volume":"29","author":"Gharabawi","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"10.1002\/14651858.CD008121.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7326\/0003-4819-147-9-200711060-00003","article-title":"Risperidone for treatment-refractory major depressive disorder: a randomized trial","volume":"147","author":"Mahmoud","year":"2007","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0024|cit24","unstructured":"McIntyre RS Canuso CM Bossie CA Turkoz I Gharabawi GM Symptoms of anxiety and relapse in patients with resistant depression 45th Annual New Clinical Drug Evaluation Unit Meeting 2005"},{"issue":"1","key":"10.1002\/14651858.CD008121.pub2-BIB0025|cit25","first-page":"159","article-title":"Augmentation with risperidone in chronic resistant depression: a double-blind placebo-controlled maintenance trial","volume":"29","author":"Nemeroff","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0026|cit26","unstructured":"Rapaport M Canuso CM Loescher A Lasser RA Gharabawi G Preliminary results from the risperidone augmentation in resistant depression trial 156th Annual Meeting of the American Psychiatric Association 2003"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0027|cit27","unstructured":"Rapaport M Canuso CM Loescher A Lasser RA Gharabawi G Preliminary results from the risperidone augmentation in resistant repression trial 157th Annual Meeting of the American Psychiatric Association 2003"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0028|cit28","unstructured":"Rapaport M Canuso CM Rouillon F Leblanc J Young AH Loescher A Results from the augmentation with risperidone in resistant depression trial 157th Annual Meeting of the American Psychiatric Association 2004"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1038\/sj.npp.1301113","article-title":"Effects of risperidone augmentation in patients with treatment-resistant depression: results of open-label treatment followed by double-blind continuation","volume":"31","author":"Rapaport","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1002\/14651858.CD008121.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/026988119901300307","article-title":"Amisulpride in medium-term treatment of dysthymia: a six-month, double-blind safety study versus amitriptyline","volume":"13","author":"Ravizza","year":"1999","journal-title":"Journal of Psychopharmacology"},{"issue":"8","key":"10.1002\/14651858.CD008121.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.4088\/JCP.v69n0805","article-title":"Efficacy of risperidone augmentation to antidepressants in the management of suicidality in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study","volume":"69","author":"Reeves","year":"2008","journal-title":"Journal of Clinical Psychiatry"},{"issue":"4","key":"10.1002\/14651858.CD008121.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/01.jcp.0000130557.08996.7a","article-title":"A double-blind, randomized study of olanzapine and olanzapine\/fluoxetine combination for major depression with psychotic features","volume":"24","author":"Rothschild","year":"2004","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"4","key":"10.1002\/14651858.CD008121.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/01.jcp.0000130557.08996.7a","article-title":"A double-blind, randomized study of olanzapine and olanzapine\/fluoxetine combination for major depression with psychotic features","volume":"24","author":"Rothschild","year":"2004","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"1","key":"10.1002\/14651858.CD008121.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1176\/appi.ajp.158.1.131","article-title":"A novel augmentation strategy for treating resistant major depression","volume":"158","author":"Shelton","year":"2001","journal-title":"American Journal of Psychiatry"},{"issue":"10","key":"10.1002\/14651858.CD008121.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.4088\/JCP.v66n1012","article-title":"Olanzapine\/fluoxetine combination for treatment-resistant depression: a controlled study of SSRI and nortriptyline resistance","volume":"66","author":"Shelton","year":"2005","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-0327(97)00139-0","article-title":"Amisulpride versus fluoxetine in patients with dysthymia or major depression in partial remission","volume":"48","author":"Smeraldi","year":"1998","journal-title":"Journal of Affective Disorders"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4088\/JCP.v68n0207","article-title":"A randomized, double-blind comparison of olanzapine\/fluoxetine combination, olanzapine, and fluoxetine in treatment-resistant major depressive disorder","volume":"68","author":"Thase","year":"2007","journal-title":"Journal of Clinical Psychiatry"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4088\/JCP.v68n0207","article-title":"A randomized, double-blind comparison of olanzapine\/fluoxetine combination, olanzapine, and fluoxetine in treatment-resistant major depressive disorder","volume":"68","author":"Thase","year":"2007","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0039|cit39","doi-asserted-by":"crossref","unstructured":"Weisler R Joyce M McGill L Lazarus A Astr\u00f6m M Brecher M Extended release quetiapine fumarate (quetiapine XR) monotherapy for major depressive disorder (MDD): a double-blind, placebo-controlled study 161st Annual Meeting of the American Psychiatric Association 2008","DOI":"10.1017\/S1092852900020307"},{"issue":"7","key":"10.1002\/14651858.CD008121.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"975","DOI":"10.4088\/JCP.v65n0714","article-title":"The effectiveness of olanzapine, risperidone, quetiapine, and ziprasidone as augmentation agents in treatment-resistant major depressive disorder","volume":"65","author":"Barbee","year":"2004","journal-title":"Journal of Clinical Psychiatry"},{"issue":"10","key":"10.1002\/14651858.CD008121.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0011-393X(97)80113-0","article-title":"An open-label, randomized, prospective comparison of sertraline and amisulpride in the treatment of dysthymia in the elderly","volume":"58","author":"Bellino","year":"1997","journal-title":"Current Therapeutic Research"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0042|cit42","first-page":"1","article-title":"Pharmacological treatment of dysthymia: a clinical trial","volume":"32","author":"Bogetto","year":"1997","journal-title":"Rivista di Psichiatria"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0043|cit43","first-page":"129","article-title":"Controlled study of venlafaxine combined with quetiapine in refractory depression","volume":"11","author":"Cao","year":"2005","journal-title":"Journal of Clinical Psychosomatic Diseases"},{"issue":"4","key":"10.1002\/14651858.CD008121.pub2-BIB0044|cit44","first-page":"247","article-title":"A control study of citalopram combined with quetiapine in the treatment of female depression","volume":"12","author":"Deng","year":"2006","journal-title":"Journal of Clinical Psychosomatic Diseases"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0045|cit45","unstructured":"Doree JP Tourjman SV Kunicki S Desrosiers J Vanier C Elie R Comparison of quetiapine versus lithium treatment of resistant depression Annual Meeting APA 2004"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0046|cit46","first-page":"268","article-title":"A clinical observation of the effect of paroxetine with small-dose olanzapine in depression","volume":"17","author":"Liu","year":"2005","journal-title":"Shanghai Archives of Psychiatry"},{"issue":"36","key":"10.1002\/14651858.CD008121.pub2-BIB0047|cit47","first-page":"6","article-title":"Effect and safety of the treatment for comorbid anxiety and depression by use of short term and low dose olanzapine in combination with fluoxetine","volume":"9","author":"Liu","year":"2005","journal-title":"Chinese Journal of Clinical Rehabilitation"},{"issue":"8","key":"10.1002\/14651858.CD008121.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1001\/archgenpsychiatry.2009.79","article-title":"A double- blind randomised controlled trial of olanzapine plus sertraline versus olanzapine plus placebo for psychotic depression","volume":"66","author":"Meyers","year":"2009","journal-title":"Archives of General Psychiatry"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00004714-199804000-00003","article-title":"Risperidone versus haloperidol and amitriptyline in the treatment of patients with a combined psychotic and depressive syndrome","volume":"18","author":"Muller-Siecheneder","year":"1998","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4088\/JCP.v65n0212","article-title":"Ziprasidone augmentation of selective serotonin reuptake inhibitors (SSRIs) for SSRI-resistant major depressive disorder","volume":"65","author":"Papakostas","year":"2004","journal-title":"Journal of Clinical Psychiatry"},{"issue":"8","key":"10.1002\/14651858.CD008121.pub2-BIB0051|cit51","first-page":"254","article-title":"Improvement of sleep and anxiety in patients with major depression with fluoxetine combined with small dose of olanzapine","volume":"9","author":"Qu","year":"2005","journal-title":"Chinese Journal of Clinical Rehabilitation"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0165-0327(01)00327-5","article-title":"A comparison of paroxetine and amisulpride in the treatment of dysthymic disorder","volume":"70","author":"Rocca","year":"2002","journal-title":"Journal of Affective Disorders"},{"issue":"4","key":"10.1002\/14651858.CD008121.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1521\/suli.2008.38.4.403","article-title":"Correlates of suicidality among patients with psychotic depression","volume":"38","author":"Schaffer","year":"2008","journal-title":"Suicide and Life Threatening Behaviour"},{"issue":"1","key":"10.1002\/14651858.CD008121.pub2-BIB0054|cit54","first-page":"238","article-title":"Risperidone vs. bupropion combined with SSRIs in treatment resistant unipolar major depression","volume":"30","author":"Shelton","year":"2005","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1002\/14651858.CD008121.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.4088\/JCP.v66n1002","article-title":"Aripiprazole augmentation of antidepressants for the treatment of partially responding and nonresponding patients with major depressive disorder","volume":"66","author":"Simon","year":"2005","journal-title":"Journal of Clinical Psychiatry"},{"issue":"52","key":"10.1002\/14651858.CD008121.pub2-BIB0056|cit56","first-page":"10486","article-title":"Venlafaxine combined with low dose risperidone for treatment-resistant depression","volume":"11","author":"Song","year":"2007","journal-title":"Journal of Clinical Rehabilitative Tissue Engineering Research"},{"issue":"7","key":"10.1002\/14651858.CD008121.pub2-BIB0057|cit57","first-page":"548","article-title":"Curative effect of paroxetine combined with quetiapine in treating depression","volume":"22","author":"Yang","year":"2006","journal-title":"Occupational Health"},{"issue":"1","key":"10.1002\/14651858.CD008121.pub2-BIB0058|cit58","first-page":"9","article-title":"A study of the effect of small dose risperidone in depression without psychotic symptoms","volume":"17","author":"Ye","year":"2004","journal-title":"Shandong Archives of Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.euroneuro.2005.10.005","article-title":"A double-blind, randomised, controlled clinical trial of acetyl-l-carnitine vs. amisulpride in the treatment of dysthymia","volume":"16","author":"Zanardi","year":"2006","journal-title":"European Neuropsychopharmacology"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0060|cit60","first-page":"85","article-title":"Clinical study on treatment of depression with risperidone combined with venlafaxine","volume":"16","author":"Zhou","year":"2004","journal-title":"Medical Journal of National Defending Forces in North China"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0061|cit61","unstructured":"The Effects of Quetiapine XR on Cognition, Mood and Anxiety Symptoms in SSRI-Resistant Unipolar Depression \u2028 NCT00517387 Ongoing study September 2007"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0062|cit62","unstructured":"A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy. \u2028 NCT00683852 Ongoing study July 2008"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0063|cit63","unstructured":"An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients. \u2028 NCT00520507 Ongoing study October 2007"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0064|cit64","unstructured":"Olanzapine Augmentation Therapy in Treatment-Resistant Depression: a Double-Blind Placebo-Controlled Trial \u2028 NCT00273624 Ongoing study June 2005"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0065|cit65","unstructured":"A 12-Week, Placebo Controlled Trial of Ziprasidone as single treatment regimen for Major Depressive Disorder (Geodon) \u2028 NCT00555997 Ongoing study March 2008"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0066|cit66","unstructured":"Ziprasidone Augmentation of SSRIs for Patients With Major Depressive Disorder (MDD) That do Not Sufficiently Respond to Treatment With SSRIs \u2028 NCT00633399 Ongoing study July 2008"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0067|cit67","unstructured":"A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome \u2028 NCT00675896 Ongoing study April 2007"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0068|cit68","unstructured":"Venlafaxine Augmentation in treatment-resistant Depression \u2028 NCT00253266 Ongoing study April 2008"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0069|cit69","unstructured":"Treatment of major depressive disorder with ziprasidone \u2028 NCT00657592 Ongoing study March 2008"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0070|cit70","unstructured":"Quetiapine in Co-Morbid Depressive and Anxiety Disorders \u2028 NCT00688818 Ongoing study June 2008"},{"issue":"11","key":"10.1002\/14651858.CD008121.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","article-title":"Antipsychotic-induced weight gain: a comprehensive research synthesis","volume":"156","author":"Allison","year":"1999","journal-title":"American Journal of Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/bmj.313.7066.1200","article-title":"Detecting skewness from summary information","volume":"313","author":"Altman","year":"1996","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0073|cit73","first-page":"1","article-title":"Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines","volume":"Epub","author":"Anderson","year":"2008","journal-title":"Journal of Psychopharmacology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0074|cit74","volume-title":"Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM III)","author":"American Psychiatric Association","year":"1980"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0075|cit75","volume-title":"Diagnostic and Statistical Manual of Mental Disorders, 3rd edition- Revised (DSM-III-R)","author":"American Psychiatric Association","year":"1987"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0076|cit76","volume-title":"Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV)","author":"American Psychiatric Association","year":"1994"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0893-133X(97)00112-7","article-title":"Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence","volume":"18","author":"Arnt","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1600-0447.2003.00283.x","article-title":"Off-label and non-classical prescriptions of antipsychotic agents in ordinary in-patient practice","volume":"109","author":"Barbui","year":"2004","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0079|cit79","volume-title":"Psychische Erkrankungen. Klinik und Therapie","author":"Berger","year":"2004"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/bmj.315.7108.600","article-title":"Statistics notes. Trials randomised in clusters","volume":"315","author":"Bland","year":"1997","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0081|cit81","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006531","article-title":"Paroxetine versus other anti-depressive agents for depression","author":"Cipriani","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1176\/appi.ajp.161.3.414","article-title":"Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of one-year studies","volume":"161","author":"Correll","year":"2004","journal-title":"American Journal of Psychiatry"},{"issue":"5","key":"10.1002\/14651858.CD008121.pub2-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2165\/00023210-200923050-00002","article-title":"Utility of atypical antipsychotics in the treatment of resistant unipolar depression","volume":"23","author":"Debattista","year":"2009","journal-title":"CNS Drugs"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"Der-Simonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/BF02599201","article-title":"The unit of analysis error in studies about physicians' patient care behavior","volume":"7","author":"Divine","year":"1992","journal-title":"Journal of General Internal Medicine"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1176\/ps.2008.59.5.507","article-title":"Who are the new users of antipsychotic medications?","volume":"59","author":"Domino","year":"2008","journal-title":"Psychiatric Services"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jclinepi.2005.06.006","article-title":"Imputing missing standard deviations in meta-analysis can provide accurate results","volume":"59","author":"Furukawa","year":"2006","journal-title":"Journal of Clinical Epidemiology"},{"issue":"2","key":"10.1002\/14651858.CD008121.pub2-BIB0089|cit89","first-page":"103","article-title":"When depression does not end. Resistant depression: recent clinical and therapeutic aspects","volume":"62","author":"Gayetot","year":"2007","journal-title":"Review Medical de Liege"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.euroneuro.2009.04.003","article-title":"Advantages and disadvantages of combination treatment with antipsychotics: ECNP Consensus Meeting, March 2008, Nice","volume":"19","author":"Goodwin","year":"2009","journal-title":"European Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/oxfordjournals.aje.a009904","article-title":"Components of variance and intraclass correlations for the design of community-based surveys and intervention studies: data from the Health Survey for England 1994","volume":"149","author":"Gulliford","year":"1999","journal-title":"American Journal of Epidemiology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0092|cit92","volume-title":"Clinical Global Impressions - ECDEU Assessment Manual Psychopharmacology (DHEW Publ No ADM 76-338)","author":"Guy","year":"1976"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"British Journal of Medical Psychology"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0094|cit94","first-page":"56","article-title":"A rating scale of depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"Journal of Neurology"},{"issue":"7414","key":"10.1002\/14651858.CD008121.pub2-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0096|cit96","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008] The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org 2008","DOI":"10.1002\/9780470712184"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1440-1819.2005.01397.x","article-title":"Twelve-month prevalence, severity and treatment of common mental disorders in communities in Japan: preliminary finding from the World mental Health Japan Survey 2002-2003","volume":"59","author":"Kawakami","year":"2005","journal-title":"Psychiatry and Clinical Neurosciences"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1001\/jama.285.15.1987","article-title":"The CONSORT Statement: revised recommendations for improving the quality of reports of parallel-group randomized trials","volume":"285","author":"Moher","year":"2001","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"British Journal of Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1176\/appi.ajp.2009.09030312","article-title":"Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials","volume":"166","author":"Nelson","year":"2009","journal-title":"American Journal of Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"826","DOI":"10.4088\/JCP.v68n0602","article-title":"Augmentation of antidepressants with atypical antipsychotic medication for treatment-resistant major depressive disorder: a meta-analysis","volume":"68","author":"Papakostas","year":"2007","journal-title":"Journal of Clinical Psychiatry"},{"issue":"11","key":"10.1002\/14651858.CD008121.pub2-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1517\/14656566.8.11.1693","article-title":"Novel uses for risperidone: focus on depressive, anxiety and behavioral disorders","volume":"8","author":"Ravindran","year":"2007","journal-title":"Expert Opinion in Pharmacotherapy"},{"issue":"4","key":"10.1002\/14651858.CD008121.pub2-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s11920-003-0062-9","article-title":"Treatment for mood and anxiety disorders: quetiapine and aripiprazole","volume":"5","author":"Sajatovic","year":"2003","journal-title":"Current Psychiatry Reports"},{"issue":"18","key":"10.1002\/14651858.CD008121.pub2-BIB0104|cit104","first-page":"1","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"8","author":"Schulz","year":"2010","journal-title":"BMC Medicine"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0105|cit105","first-page":"1","article-title":"Seroquel led antipsychotics sales in 2006","volume":"35","author":"Vital","year":"2007","journal-title":"Clinical Psychiatric News"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0106|cit106","volume-title":"International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10)","author":"World Health Organization","year":"1992"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0107|cit107","volume-title":"The European Health Report 2005","author":"World Health Organization","year":"2005"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1192\/bjp.bp.105.010470","article-title":"Pharmacologic treatment for unipolar psychotic depression","volume":"188","author":"Wijkstra","year":"2006","journal-title":"British Journal of Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0109|cit109","first-page":"40","article-title":"Atypical antipsychotics in bipolar depression: potential mechanisms of action","volume":"66 (Suppl 5)","author":"Yatham","year":"2005","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1002\/14651858.CD008121.pub2-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jpsychires.2004.03.007","article-title":"Derivation of a definition of remission on the Montgomery-Asberg depression rating scale corresponding to the definition of remission on the Hamilton rating scale for depression","volume":"38","author":"Zimmermann","year":"2004","journal-title":"Journal of Psychiatric Research"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD008121.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:08:55Z","timestamp":1744589335000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008121.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Common Mental Disorders Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,8]]},"references-count":110,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008121.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,8]]}}}