{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:51:01Z","timestamp":1774259461240,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd008125","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000}}],"reference-count":55,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008125.pub2","type":"journal-article","created":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T16:06:25Z","timestamp":1263830785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sulpiride augmentation for schizophrenia"],"prefix":"10.1002","volume":"2012","author":[{"given":"Jijun","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; Department of EEG Source Imaging; Shanghai Shanghai China 200030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro M","family":"Omori","sequence":"additional","affiliation":[{"name":"Toyokawa City Hospital; Department of Psychiatry; Koumei 1-19 Toyokawa Aichi Japan 442-8561"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Fenton","sequence":"additional","affiliation":[{"name":"National Institute for Health and Clinical Excellence; Database of Uncertainties about the Effects of Treatments (DUETs); Level 1A, City Tower, Piccadilly Plaza Middle Way Manchester UK M1 4BD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo GO","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo; Brazilian Cochrane Centre; Rua Pedro de Toledo 598 S\u00e3o Paulo SP Brazil 04039-001"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"key":"10.1002\/14651858.CD008125.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1192\/bjp.171.6.569","article-title":"Sulpiride augmentation in people with schizophrenia partially responsive to clozapine. A double-blind, placebo-controlled study","volume":"171","author":"Shiloh","year":"1997","journal-title":"British Journal of Psychiatry"},{"issue":"2","key":"10.1002\/14651858.CD008125.pub2-BIB0002|cit2","first-page":"148","article-title":"A clinical effect and following-up study about sulpiride and clozapine for 105 cases of the schizophrenia type ?","volume":"11","author":"Wang","year":"1994","journal-title":"Journal of Xinxiang Medical College"},{"issue":"5","key":"10.1002\/14651858.CD008125.pub2-BIB0003|cit3","first-page":"806","article-title":"Observation on the effect of clozapine and sulpiride on negative symptom schizophrenia patients","volume":"6","author":"Xu","year":"2006","journal-title":"China Tropical Medicine"},{"issue":"4","key":"10.1002\/14651858.CD008125.pub2-BIB0004|cit4","first-page":"204","article-title":"A controlled trial comparing chlorimipramine and sulpiride as adjunct to clozapine in the treatment of negative symptoms of schizophrenia","volume":"9","author":"Zhu","year":"1999","journal-title":"Journal of Clinical Psychological Medicine"},{"issue":"1","key":"10.1002\/14651858.CD008125.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00004850-200401000-00004","article-title":"Sulpiride augmentation of olanzapine in the management of treatment-resistant chronic schizophrenia: evidence for improvement of mood symptomatology","volume":"19","author":"Kotler","year":"2004","journal-title":"International Clinical Psychopharmacology"},{"issue":"1","key":"10.1002\/14651858.CD008125.pub2-BIB0006|cit6","first-page":"39","article-title":"A controlled trial comparing venlafaxine versus sulpiride as adjunct in the treatment of negative symptoms of schizophrenia","volume":"15","author":"Li","year":"2003","journal-title":"Shanghai Archives of Psychiatry"},{"issue":"2","key":"10.1002\/14651858.CD008125.pub2-BIB0007|cit7","first-page":"235","article-title":"Comparative study on clinical effects of timiperone injection and sulpiride injection for schizophrenia by a double-blind test","volume":"1","author":"Nakazawa","year":"1985","journal-title":"Journal of Clinical Therapeutics and Medicines"},{"issue":"7","key":"10.1002\/14651858.CD008125.pub2-BIB0008|cit8","first-page":"24","article-title":"Observation on intractable auditory hallucination treated by injecting sulpiride into acupoints","volume":"16","author":"Yang","year":"2000","journal-title":"Journal of Practical Traditional Chinese Medicine"},{"issue":"6","key":"10.1002\/14651858.CD008125.pub2-BIB0009|cit9","first-page":"20","article-title":"A comparison study of using clozapine in combination with sulpiride and simple using clozapine or sulpiride in treatment schizophrenia","volume":"2","author":"Gong","year":"2001","journal-title":"Journal of Chinease Clinical Medicine"},{"issue":"2","key":"10.1002\/14651858.CD008125.pub2-BIB0010|cit10","first-page":"87","article-title":"A control study of clozapine in combination with sulpiride in alleviating the negative symptoms of schizophrenia","volume":"29","author":"Liu","year":"1996","journal-title":"Chinese Journal of Psychiatry"},{"issue":"7","key":"10.1002\/14651858.CD008125.pub2-BIB0011|cit11","first-page":"639","article-title":"Clinical controlled studies of olanzapine combined with sulpiride therapy in refractory schizophrenia","volume":"14","author":"Wu","year":"2005","journal-title":"Chinese Journal of Behavioral Medical Science"},{"issue":"4","key":"10.1002\/14651858.CD008125.pub2-BIB0012|cit12","first-page":"250","article-title":"A double blind randomized study comparing clozapine and clozapine combination with sulpiride in the treatment of schizophrenia","volume":"12","author":"Yao","year":"1999","journal-title":"Sichuan Mental Health"},{"issue":"3","key":"10.1002\/14651858.CD008125.pub2-BIB0013|cit13","first-page":"224","article-title":"Comparison of sulpiride and chlorpromazini in treatment of negative psychotic symptoms with chronic schizophrenia","volume":"11","author":"Zhao","year":"2003","journal-title":"Health Psychology Journal"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/bmj.313.7066.1200","article-title":"Detecting skewness from summary information","volume":"313","author":"Altman","year":"1996","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0015|cit15","unstructured":"Andreasen NC Scale for the assessment of positive symptoms (SAPS) The University of Iowa 1984"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0016|cit16","first-page":"53","article-title":"Scale for the assessment of negative symptoms (SANS)","volume":"7","author":"Andreasen","year":"1989","journal-title":"British Journal of Psychiatry"},{"issue":"7108","key":"10.1002\/14651858.CD008125.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/bmj.315.7108.600","article-title":"Statistics notes. Trials randomised in clusters","volume":"315","author":"Bland","year":"1997","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD008125.pub2-BIB0018|cit18","first-page":"405","article-title":"The problem of therapeutic efficacy indices. 3. Comparison of the indices and their use","volume":"54","author":"Boissel","year":"1999","journal-title":"Therapie"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0019|cit19","first-page":"1069","article-title":"Subjective Treatment Emergent Symptoms Scale (STESS)","volume":"21","author":"Campbell","year":"1985","journal-title":"Psychopharmacology Bulletin"},{"issue":"10","key":"10.1002\/14651858.CD008125.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1056\/NEJM199403103301006","article-title":"Schizophrenia","volume":"330","author":"Carpenter","year":"1994","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0021|cit21","first-page":"560","article-title":"Study of the effects of sulpiride on the mental state of 40 mental patients","volume":"2","author":"Carrere","year":"1968","journal-title":"Annales Medico Psychologiques Paris"},{"issue":"4","key":"10.1002\/14651858.CD008125.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/schbul\/23.4.663","article-title":"Evaluation of treatment-resistant schizophrenia","volume":"23","author":"Conley","year":"1997","journal-title":"Schizophrenia Bulletin"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0023|cit23","unstructured":"Deeks J Issues in the selection for meta-analyses of binary data Proceedings of the 8th International Cochrane Colloquium; 2000 Oct 25-28th; Cape Town, South Africa 2000"},{"issue":"6","key":"10.1002\/14651858.CD008125.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/BF02599201","article-title":"The unit of analysis error in studies about physicians' patient care behavior","volume":"7","author":"Divine","year":"1992","journal-title":"Journal of General Internal Medicine"},{"issue":"36","key":"10.1002\/14651858.CD008125.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1073\/pnas.0805493105","article-title":"Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation","volume":"105","author":"Dong","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"19","key":"10.1002\/14651858.CD008125.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1002\/sim.1301","article-title":"Issues in the meta-analysis of cluster randomized trials","volume":"21","author":"Donner","year":"2002","journal-title":"Statistics in medicine"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"13","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD008125.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"issue":"1","key":"10.1002\/14651858.CD008125.pub2-BIB0029|cit29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000059.pub2","article-title":"Clozapine versus typical neuroleptic medication for schizophrenia","author":"Essali","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-244X-5-26","article-title":"Antipsychotic monotherapy and polypharmacy in the naturalistic treatment of schizophrenia with atypical antipsychotics","volume":"5","author":"Faries","year":"2005","journal-title":"BMC Psychiatry"},{"issue":"9","key":"10.1002\/14651858.CD008125.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/oxfordjournals.aje.a009904","article-title":"Components of variance and intraclass correlations for the design of community-based surveys and intervention studies: data from the Health Survey for England 1994","volume":"149","author":"Gulliford","year":"1999","journal-title":"American journal of epidemiology"},{"issue":"7414","key":"10.1002\/14651858.CD008125.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0033|cit33","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008] The Cochrane Collaboration, 2008 Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184"},{"issue":"7303","key":"10.1002\/14651858.CD008125.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/bmj.323.7303.42","article-title":"Systematic reviews in health care: Assessing the quality of controlled clinical trials","volume":"323","author":"Juni","year":"2001","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0035|cit35","volume-title":"Positive and Negative Syndrome Scale(PANSS) manual","author":"Kay","year":"1986"},{"issue":"5-6","key":"10.1002\/14651858.CD008125.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.eurpsy.2004.12.007","article-title":"Randomized controlled augmentation trials in clozapine-resistant schizophrenic patients: a critical review","volume":"20","author":"Kontaxakis","year":"2005","journal-title":"European psychiatry : the journal of the Association of European Psychiatrists"},{"issue":"2-3","key":"10.1002\/14651858.CD008125.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.schres.2005.04.008","article-title":"What does the PANSS mean?","volume":"79","author":"Leucht","year":"2005","journal-title":"Schizophrenia research"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1192\/bjp.187.4.366","article-title":"Clinical implications of Brief Psychiatric Rating Scale scores","volume":"187","author":"Leucht","year":"2005","journal-title":"British Journal of Psychiatry"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1192\/bjp.176.3.249","article-title":"Unpublished rating scales: a major source of bias in randomised controlled trials of treatments for schizophrenia","volume":"176","author":"Marshall","year":"2000","journal-title":"British Journal of Psychiatry"},{"issue":"7400","key":"10.1002\/14651858.CD008125.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1136\/bmj.326.7400.1171","article-title":"Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications","volume":"326","author":"Melander","year":"2003","journal-title":"BMJ"},{"issue":"9263","key":"10.1002\/14651858.CD008125.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(00)04337-3","article-title":"The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials","volume":"357","author":"Moher","year":"2001","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD008125.pub2-BIB0042|cit42","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007811.","article-title":"Sulpiride versus placebo for schizophrenia","author":"Omori","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD008125.pub2-BIB0043|cit43","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008126","article-title":"Sulpiride versus other antipsychotics for schizophrenia","author":"Omori","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2466\/pr0.1962.10.3.799","article-title":"The Brief Psychiatric Rating Scale","volume":"10","author":"Overall","year":"1962","journal-title":"Psychological Reports"},{"issue":"1","key":"10.1002\/14651858.CD008125.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3109\/00048679609076070","article-title":"Drug strategies and treatment-resistant schizophrenia","volume":"30","author":"Pantelis","year":"1996","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0046|cit46","doi-asserted-by":"crossref","unstructured":"Procopio M Sulpiride augmentation on schizophrenia British Journal of Psychiatry 1998 449 50","DOI":"10.1192\/bjp.172.5.449c"},{"issue":"5","key":"10.1002\/14651858.CD008125.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/00004714-200010000-00002","article-title":"Olanzapine and sulpiride: A preliminary study of combination\/augmentation in patients with treatment-resistant schizophrenia","volume":"20","author":"Raskin","year":"2000","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"4","key":"10.1002\/14651858.CD008125.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.euroneuro.2005.04.009","article-title":"Size of burden of schizophrenia and psychotic disorders","volume":"15","author":"Rossler","year":"2005","journal-title":"European Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0049|cit49","volume-title":"Modern Psychometrics","author":"Rust","year":"1989"},{"issue":"5","key":"10.1002\/14651858.CD008125.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta3050","article-title":"Methods for evaluating area-wide and organisation-based interventions in health and health care: a systematic review","volume":"3","author":"Ukoumunne","year":"1999","journal-title":"Health Technology Assessment"},{"issue":"1","key":"10.1002\/14651858.CD008125.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1073\/pnas.2637013100","article-title":"DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains","volume":"101","author":"Veldic","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0052|cit52","doi-asserted-by":"crossref","unstructured":"Williams L Newton G Roberts K Finlayson S Brabbins C Clozapine-resistant schizophrenia: a positive approach British Journal of Psychiatry 2002 184 7","DOI":"10.1192\/bjp.181.3.184"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0053|cit53","unstructured":"Wu T Li Y Liu G Bian Z Li J Zhang J Xie L Ni J Investigationof authenticity of \u2019claimed\u2019 randomized controlled trials (RCTs) andquality assessment of RCT reports published in China Proceedingsof the 14th Cochrane Colloquium; 2006 Oct 23-26; Dublin Dublin 2006"},{"key":"10.1002\/14651858.CD008125.pub2-BIB0054|cit54","unstructured":"Xia J Adams CE Bhagat N Bhagat V Bhoopathi P El-Sayeh H Pinfold V Takriti Y The Leeds Outcomes Stakeholders Survey (LOSS) Study Proceedings of the 15th Cochrane Colloquium; 2007 Oct 23-27; Sao Paulo 2007"},{"issue":"1","key":"10.1002\/14651858.CD008125.pub2-BIB0055|cit55","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001162","article-title":"Sulpiride for schizophrenia","author":"Soares","year":"1999","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD008125.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:52:39Z","timestamp":1774255959000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008125.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Schizophrenia Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,1,20]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008125.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,20]]}}}