{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:03:23Z","timestamp":1793693003762,"version":"4.5.1"},"update-to":[{"DOI":"10.1002\/14651858.cd008148","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T00:00:00Z","timestamp":1283904000000}}],"reference-count":44,"publisher":"Wiley","issue":"9","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008148.pub2","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T15:37:51Z","timestamp":1283441871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy"],"prefix":"10.1002","volume":"2010","author":[{"given":"Douglas M","family":"Woudstra","sequence":"first","affiliation":[{"name":"University of Alberta; Department of Obstetrics and Gynaecology; 13619 - 108 Avenue Edmonton Alberta Canada T5M 2C7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Chandra","sequence":"additional","affiliation":[{"name":"University of Alberta; Department of Obstetrics and Gynaecology; 13619 - 108 Avenue Edmonton Alberta Canada T5M 2C7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Justus","family":"Hofmeyr","sequence":"additional","affiliation":[{"name":"University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health; Department of Obstetrics and Gynaecology, East London Hospital Complex; Frere and Cecilia Makiwane Hospitals Private Bag X 9047 East London Eastern Cape South Africa 5200"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Dowswell","sequence":"additional","affiliation":[{"name":"The University of Liverpool; Cochrane Pregnancy and Childbirth Group, School of Reproductive and Developmental Medicine, Division of Perinatal and Reproductive Medicine; First Floor, Liverpool Women's NHS Foundation Trust Liverpool UK L8 7SS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,8]]},"reference":[{"issue":"8","key":"10.1002\/14651858.CD008148.pub2-BIB0001|cit1","first-page":"473","article-title":"Maternal benefit of postpartum corticosteroid therapy in patients with HELLP (hemolysis elevated liver enzymes low platelets count) syndrome","volume":"83","author":"Bouchnak","year":"2005","journal-title":"Tunisie Medicale"},{"issue":"5","key":"10.1002\/14651858.CD008148.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.ajog.2005.07.037","article-title":"Dexamethasone treatment does not improve the outcome of women with HELLP syndrome: a double-blind, placebo-controlled, randomized clinical trial","volume":"193","author":"Fonseca","year":"2005","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD008148.pub2-BIB0004|cit3","first-page":"248","article-title":"A prospective, randomized trial comparing the efficacy of dexamethasone and betamethasone for the treatment of antepartum hellp (hemolysis, elevated liver enzymes, and low platelet count) syndrome","volume":"66","author":"Isler","year":"2001","journal-title":"Revista Chilena de Obstetricia y Ginecologia"},{"issue":"7","key":"10.1002\/14651858.CD008148.pub2-BIB0003|cit4","doi-asserted-by":"crossref","first-page":"1332-7; discuss","DOI":"10.1067\/mob.2001.115051","article-title":"A prospective, randomized trial comparing the efficacy of dexamethasone and betamethasone for the treatment of antepartum hellp (hemolysis, elevated liver enzymes, and low platelet count) syndrome","volume":"184","author":"Isler","year":"2001","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD008148.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0020-7292(02)00394-6","article-title":"Dexamethasone compared with betamethasone for glucocorticoid treatment of postpartum hellp syndrome","volume":"80","author":"Isler","year":"2003","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD008148.pub2-BIB0006|cit6","first-page":"S87","article-title":"Dexamethasone versus betamethasone for postpartum hellp syndrome: a randomized prospective clinical trial of comparative efficacy","volume":"182","author":"Isler","year":"2000","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0007|cit7","first-page":"55","article-title":"Helpful effect of high-dose corticosteroid use on Hellp syndrome","volume":"11","author":"Kadanali","year":"1997","journal-title":"Jinekoloji Ve Obstetrik Dergisi"},{"issue":"2","key":"10.1002\/14651858.CD008148.pub2-BIB0008|cit8","first-page":"80","article-title":"Clinical and laboratorial profile and complications of patients with HELLP syndrome admitted in an obstetric intensive care unit","volume":"30","author":"Katz","year":"2008","journal-title":"Revista Brasileira de Ginecologia e Obstetricia"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"282.e1","DOI":"10.1016\/j.ajog.2007.10.797","article-title":"Postpartum dexamethasone for women with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome: a double-blind, placebo-controlled, randomized clinical trial","volume":"198","author":"Katz","year":"2008","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/0002-9378(94)90054-X","article-title":"Antepartum corticosteroids: disease stabilization in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP)","volume":"171","author":"Magann","year":"1994","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0011|cit11","first-page":"410","article-title":"Antepartum corticosteroids: disease stabilization in patients with HELLP syndrome","volume":"170","author":"Magann","year":"1994","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/0002-9378(94)90055-8","article-title":"Postpartum corticosteroids: accelerated recovery from the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP)","volume":"171","author":"Magann","year":"1994","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0013|cit13","first-page":"410","article-title":"Postpartum corticosteroids: accelerated recovery from HELLP syndrome","volume":"170","author":"Magann","year":"1994","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD008148.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijgo.2006.01.017","article-title":"High-dose dexamethasone in the treatment of HELLP syndrome","volume":"93","author":"Mould","year":"2006","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"1","key":"10.1002\/14651858.CD008148.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00404-008-0865-3","article-title":"The effects of betamethasone treatment on clinical and laboratory features of pregnant women with HELLP syndrome","volume":"280","author":"Ozer","year":"2009","journal-title":"Archives of Gynecology and Obstetrics"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD008148.pub2-BIB0016|cit16","first-page":"13","article-title":"A randomized placebo-controlled trial of prolonged prednisolone administration to patients with HELLP syndrome remote from term [abstract}","volume":"23","author":"Runnard Heimel","year":"2004","journal-title":"Hypertension in Pregnancy"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejogrb.2005.11.041","article-title":"A randomised placebo-controlled trial of prolonged prednisolone administration to patients with HELLP syndrome remote from term","volume":"128","author":"Runnard Heimel","year":"2006","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"issue":"6 Suppl 1","key":"10.1002\/14651858.CD008148.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.ajog.2004.10.016","article-title":"A randomized placebo-controlled trial of prolonged prednisolone administration to patients with HELLP syndrome remote from term: maternal and neonatal complications [abstract]","volume":"191","author":"Runnard Heimel","year":"2004","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"10","key":"10.1002\/14651858.CD008148.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.placenta.2004.12.008","article-title":"The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome","volume":"26","author":"Runnard Heimel","year":"2005","journal-title":"Placenta"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0020-7292(97)00214-2","article-title":"Dexamethasone in the post-partum treatment of HELLP syndrome","volume":"59","author":"Vigil-De Gracia","year":"1997","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"2","key":"10.1002\/14651858.CD008148.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0020-7292(98)00036-8","article-title":"Effects of postpartum corticosteroids in patients with hellp syndrome","volume":"61","author":"Yalcin","year":"1998","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"4","key":"10.1002\/14651858.CD008148.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/01.AOG.0000154887.57440.d1","article-title":"Postpartum intravenous dexamethasone for severely preeclamptic patients without hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome: a randomized trial","volume":"105","author":"Barrilleaux","year":"2005","journal-title":"Obstetrics & Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD008148.pub2-BIB0023|cit23","first-page":"79","article-title":"Effects of postpartum corticosteroids in patients with HELLP syndrome","volume":"9","author":"Borekci","year":"2008","journal-title":"Journal of the Turkish German Gynecology Association Artemis"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0024|cit24","unstructured":"Morrison JC Effect on maternal thrombocytopenia in patients with HELLP syndrome of maternal steroid administration Personal communication 1992"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0025|cit25","unstructured":"Fonseca J Dexamethasone efficacy in HELLP syndrome, a multicentric, double-blind, placebo-controlled, randomized clinical trial http:\/\/clinicaltrials.gov\/ct2\/show\/record\/NCT01138839"},{"issue":"1 Pt 1","key":"10.1002\/14651858.CD008148.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0002-9378(99)70178-X","article-title":"Neonatal outcome in severe preeclampsia at 24 to 36 weeks' gestation: does the HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome matter?","volume":"180","author":"Abramovici","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0027|cit27","first-page":"70","article-title":"Antepartum reversal of hematologic abnormalities associated with the HELLP syndrome. A report of three cases","volume":"31","author":"Clark","year":"1986","journal-title":"Journal of Reproductive Medicine"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0028|cit28","doi-asserted-by":"crossref","DOI":"10.1002\/9780470693926.ch15","article-title":"Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis","volume-title":"Systematic reviews in health care: meta-analysis in context","author":"Deeks","year":"2001"},{"issue":"2","key":"10.1002\/14651858.CD008148.pub2-BIB0029|cit29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007756","article-title":"Interventions for treating pre-eclampsia and its consequences: generic protocol","author":"Duley","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2393-9-8","article-title":"The HELLP syndrome: clinical issues and management. A Review","volume":"9","author":"Haram","year":"2009","journal-title":"BMC Pregnancy and Childbirth"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0031|cit31","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009 Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1479-828X.1993.tb02374.x","article-title":"Corticosteroids for the enhancement of fetal lung maturity: impact on the gravida with preeclampsia and the HELLP syndrome","volume":"33","author":"Magann","year":"1993","journal-title":"Australian and New Zealand Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/0002-9378(91)91429-Z","article-title":"The natural history of HELLP syndrome: patterns of disease progression and regression","volume":"164","author":"Martin","year":"1991","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"6 Pt 1","key":"10.1002\/14651858.CD008148.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0002-9378(99)70022-0","article-title":"The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification","volume":"180","author":"Martin","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0035|cit35","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2008"},{"issue":"1","key":"10.1002\/14651858.CD008148.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0146-0005(00)80050-6","article-title":"Preeclampsia: what we know and what we do not know","volume":"24","author":"Roberts","year":"2000","journal-title":"Seminars in Perinatology"},{"issue":"3","key":"10.1002\/14651858.CD008148.pub2-BIB0037|cit37","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004454.pub2","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","author":"Roberts","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD008148.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0002-9378(93)90043-I","article-title":"Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)","volume":"169","author":"Sibai","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"5 Pt 1","key":"10.1002\/14651858.CD008148.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/01.AOG.0000126245.35811.2a","article-title":"Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count","volume":"103","author":"Sibai","year":"2004","journal-title":"Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0020-7292(97)00214-2","article-title":"Dexamethasone in the postpartum treatment of HELLP syndrome","volume":"59","author":"Vigil-De Gracia","year":"1997","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"2","key":"10.1002\/14651858.CD008148.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1471-0528.1995.tb09062.x","article-title":"Temporising management of severe pre-eclampsia with and without the HELLP syndrome","volume":"102","author":"Visser","year":"1995","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD008148.pub2-BIB0042|cit42","first-page":"781","article-title":"Hepatic dysfunction, thrombocytopenia and late onset preeclampsia. A report of three cases","volume":"32","author":"Yeast","year":"1987","journal-title":"Journal of Reproductive Medicine"},{"issue":"1","key":"10.1002\/14651858.CD008148.pub2-BIB0043|cit43","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002076.pub3","article-title":"Corticosteroids for HELLP syndrome in pregnancy","author":"Matchaba","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD008148.pub2-BIB0044|cit44","article-title":"Corticosteroids for HELLP syndrome in pregnancy","author":"Matchaba","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD008148.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T10:16:49Z","timestamp":1763029009000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008148.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Pregnancy and Childbirth Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,9,8]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,9]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008148.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,8]]}}}