{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:17:40Z","timestamp":1789449460902,"version":"build-2803163510"},"update-to":[{"DOI":"10.1002\/14651858.cd008276","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000}}],"reference-count":144,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008276.pub2","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T14:51:04Z","timestamp":1502895064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Pharmacotherapy for hypertension in adults aged 18 to 59 years"],"prefix":"10.1002","volume":"2017","author":[{"given":"Vijaya M","family":"Musini","sequence":"first","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Science Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Gueyffier","sequence":"additional","affiliation":[{"name":"Hopital Cardio-Vasculaire et Pneumologique Louis Pradel; UMR5558, CNRS et Universit\u00e9 Claude Bernard - Service de Pharmacologie & Toxicologie; Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorri","family":"Puil","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Science Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M","family":"Salzwedel","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Science Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Wright","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Science Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"10.1002\/14651858.CD008276.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(70)91577-1","article-title":"Hypotensive therapy in stroke survivors","volume":"1","author":"Carter","year":"1970","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1001\/jama.1974.03230420021019","article-title":"Effect of antihypertensive treatment on stroke recurrence","volume":"229","author":"Hypertension-Stroke Cooperative Study Group","year":"1974","journal-title":"JAMA"},{"issue":"8246","key":"10.1002\/14651858.CD008276.pub2-BIB0003|cit3","first-page":"539","article-title":"Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. Report of Medical Research Council Working Party on Mild to Moderate Hypertension","volume":"2","author":"Anonymous","year":"1981","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD008276.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/j.1552-4604.1987.tb03012.x","article-title":"Comparison of the antihypertensive efficacy and adverse reactions of two doses of bendrofluazide and hydrochlorothiazide and the effect of potassium supplementation on the hypotensive action of bendrofluazide: sub-studies of the Medical Research Council's trials of treatment of mild hypertension: Medical Research Council Working Party","volume":"27","author":"Anonymous","year":"1987","journal-title":"Journal of Clinical Pharmacology"},{"issue":"4","key":"10.1002\/14651858.CD008276.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/j.1552-4604.1987.tb03012.x","article-title":"Comparison of the antihypertensive efficacy and adverse reactions to two doses of bendrofluazide and hydrochlorothiazide and the effect of potassium supplementation on the hypotensive action of bendrofluazide: substudies of the Medical Research Council's trials of treatment of hypertension: Medical Research Council Working Party","volume":"27","author":"Anonymous","year":"1987","journal-title":"Journal of Clinical Pharmacology"},{"issue":"3","key":"10.1002\/14651858.CD008276.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1136\/hrt.59.3.364","article-title":"Coronary heart disease in Medical Research Council trial of mild hypertension. Medical Research Council Working Party on Mild Hypertension","volume":"59","author":"Anonymous","year":"1988","journal-title":"British Heart Journal"},{"issue":"6074","key":"10.1002\/14651858.CD008276.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1136\/bmj.1.6074.1437","article-title":"Randomised controlled trial of treatment of mild hypertension: design and pilot trial. Report of the Medical Research Council Working party on Mild to Moderate Hypertension","volume":"1","author":"Anonymous","year":"1977","journal-title":"BMJ"},{"issue":"6636","key":"10.1002\/14651858.CD008276.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1136\/bmj.296.6636.1565","article-title":"Stroke and coronary heart disease in mild hypertension: risk factors and the value of treatment. Medical Research Council Working Party on Mild Hypertension","volume":"296","author":"Anonymous","year":"1988","journal-title":"BMJ"},{"issue":"6488","key":"10.1002\/14651858.CD008276.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/bmj.291.6488.97","article-title":"MRC trial of treatment of mild hypertension: principal results","volume":"291","author":"Medical Research Council Working Party","year":"1985","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0010|cit10","first-page":"563s","article-title":"Medical Research Council's Treatment Trial for Mild Hypertension: an interim report","volume":"51","author":"Miall","year":"1976","journal-title":"Clinical Science and Molecular Medicine"},{"issue":"6","key":"10.1002\/14651858.CD008276.pub2-BIB0011|cit11","first-page":"616","article-title":"Results of the MRC (UK) trial of drug therapy for mild hypertension","volume":"10","author":"Peart","year":"1987","journal-title":"Clinical and Investigative Medicine. Medecine Clinique et Experimentale"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0016|cit12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0002-9343(80)90438-6","article-title":"Treatment of mild hypertension: a five year controlled drug trial. The OSLO study","volume":"69","author":"Helgeland","year":"1980","journal-title":"American Journal of Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0012|cit13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.0954-6820.1979.tb00805.x","article-title":"Mild hypertension - early drug treatment or follow-up only? the Oslo study","volume":"626","author":"Helgeland","year":"1979","journal-title":"Acta Medica Scandinavica"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0013|cit14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0002-9343(78)90177-8","article-title":"Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension","volume":"64","author":"Helgeland","year":"1978","journal-title":"American Journal of Medicine"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD008276.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000184565","article-title":"Oslo study: treatment of mild hypertension","volume":"47","author":"Helgeland","year":"1987","journal-title":"Nephron"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0014|cit16","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/0002-9343(84)90990-2","article-title":"Serum glucose levels during long-term observation of treated and untreated men with mild hypertension","volume":"76","author":"Helgeland","year":"1984","journal-title":"American Journal of Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0018|cit17","first-page":"79","article-title":"Coronary risk factors and their possible causal role in the development of coronary heart disease","volume":"32","author":"Holme","year":"1982","journal-title":"Journal Oslo City Hospital"},{"issue":"4","key":"10.1002\/14651858.CD008276.pub2-BIB0017|cit18","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/oxfordjournals.aje.a114855","article-title":"Correlates of blood pressure change in middle-aged male mild hypertensives: results from the untreated control group in the Oslo hypertension trial","volume":"127","author":"Holme","year":"1988","journal-title":"American Journal of Epidemiology"},{"issue":"Suppl II","key":"10.1002\/14651858.CD008276.pub2-BIB0019|cit19","first-page":"217","article-title":"Blood lipids and antihypertensive drugs","volume":"14","author":"Leren","year":"1983","journal-title":"Journal of Pharmacology (Paris)"},{"issue":"Suppl 2A","key":"10.1002\/14651858.CD008276.pub2-BIB0021|cit20","first-page":"306","article-title":"Coronary heart disease and treatment of hypertension. Some Oslo data","volume":"80","author":"Leren","year":"1986","journal-title":"American Journal of Medicine"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD008276.pub2-BIB0022|cit21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2165\/00003495-198600311-00008","article-title":"Oslo hypertension study","volume":"31","author":"Leren","year":"1986","journal-title":"Drugs"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0020|cit22","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/0002-8703(83)90175-8","article-title":"The Oslo study: CHD risk factors, socioeconomic influences, and interventions","volume":"106","author":"Leren","year":"1983","journal-title":"American Heart Journal"},{"issue":"Suppl II","key":"10.1002\/14651858.CD008276.pub2-BIB0023|cit23","first-page":"110","article-title":"Morbidity and mortality in mild essential hypertension","volume":"30\/31","author":"Anonymous","year":"1972","journal-title":"Circulation Research"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0024|cit24","volume-title":"Intervention trial in mild hypertension, U.S. Public Health Service Hospitals Cooperative Study Group","author":"Smith","year":"1975"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD008276.pub2-BIB0025|cit25","first-page":"98","article-title":"Treatment of mild hypertension. Results of a ten-year intervention trial","volume":"40","author":"US Public Health Service Hospital Cooperative Study Group (USPHSHCSG)","year":"1977","journal-title":"Circulation Research"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/jama.1970.03170330025003","article-title":"Effects of treatment on morbidity in hypertension II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg","volume":"213","author":"Veterans Administration Cooperative Study Group on Antihypertensive Agents","year":"1970","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1161\/01.CIR.45.5.991","article-title":"Effects of treatment on morbidity in hypertension: influence of age, diastolic pressure, and prior cardiovascular disease: further analysis of side effects","volume":"45","author":"Veterans Administration Cooperative Study Group on Antihypertensive Agents","year":"1972","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0028|cit28","first-page":"267","article-title":"Evaluation of drug treatment in mild hypertension: VA-NHLBI feasibility trial","volume":"304","author":"Anonymous","year":"1978","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0029|cit29","first-page":"1180","article-title":"Treatment of mild hypertension. Preliminary results of a two year feasibility trial","volume":"40 Suppl","author":"Perry","year":"1977","journal-title":"Circulation Research"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0030|cit30","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0140-6736(07)61303-8","article-title":"Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial","volume":"370","author":"The ADVANCE Collaborative Group","year":"2007","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1161\/01.HYP.0000086521.95630.5A","article-title":"Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)","volume":"42","author":"ALLHAT Group","year":"2003","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0895-7061(96)00037-4","article-title":"Rationale and design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)","volume":"9","author":"Davis","year":"1996","journal-title":"American Journal of Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0033|cit33","first-page":"434","article-title":"Control of moderately raised blood pressure: report of a co-operative randomized controlled trial","volume":"III","author":"Anonymous","year":"1973","journal-title":"British Medical Journal"},{"issue":"5","key":"10.1002\/14651858.CD008276.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/01.HYP.6.5.774","article-title":"The Australian Therapeutic Trial in Mild Hypertension","volume":"6","author":"Abernethy","year":"1984","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0035|cit35","first-page":"1261","article-title":"The Australian Therapeutic Trial in Mild Hypertension","volume":"1","author":"Australian National Blood Pressure Management Committee","year":"1980","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.5694\/j.1326-5377.1981.tb101027.x","article-title":"Treatment of mild hypertension in the elderly. A study initiated and administered by the National Heart Foundation of Australia","volume":"2","author":"The Management Committee","year":"1981","journal-title":"Medical Journal of Australia"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0140-6736(81)92624-6","article-title":"Beta-blockers or diuretics in hypertension? A six year follow up of blood pressure and metabolic side effects","volume":"I","author":"Berglund","year":"1981","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD008276.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1536\/ihj.35.589","article-title":"Effect of two different therapeutic approaches on total and cardiovascular mortality in a Cardiovascular Study in the Elderly (CASTEL)","volume":"35","author":"Casiglia","year":"1994","journal-title":"Japanese Heart Journal"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0039|cit39","first-page":"569","article-title":"The CASTEL project (CArdiovascular STudy in the ELderly): protocol, study design, and preliminary results of the initial survey","volume":"36","author":"Casiglia","year":"1991","journal-title":"Cardiologia"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/bmj.293.6555.1145","article-title":"Randomised trial of treatment of hypertension in elderly patients in primary care","volume":"293","author":"Coope","year":"1986","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/01.STR.24.4.543","article-title":"Trial of secondary prevention with atenolol after transient ischemic attack or non-disabling ischemic stroke","volume":"24","author":"Dutch TIA Trial Study Group","year":"1993","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0042|cit42","first-page":"300","article-title":"An international trial of antihypertensive therapy in elderly patients. Objectives, protocol and organization","volume":"275","author":"European Working Party on High Blood Pressure in the Elderly (EWPHE)","year":"1985","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD008276.pub2-BIB0043|cit43","first-page":"S105","article-title":"Isolated systolic hypertension: data from the European Working Party on High Blood Pressure in the Elderly","volume":"6","author":"O'Malley","year":"1988","journal-title":"Journal of Hypertension"},{"issue":"65","key":"10.1002\/14651858.CD008276.pub2-BIB0044|cit44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1745-6215-12-65","article-title":"Prevention of hypertension in patients with pre-hypertension: protocol for the PREVER-prevention trial","volume":"12","author":"Fuchs","year":"2011","journal-title":"Trials"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0045|cit45","first-page":"536","article-title":"Efficacy and safety of nebivolol monotherapy in Hispanics with stage I-II hypertension (Abstract)","volume":"12","author":"Punzi","year":"2010","journal-title":"Journal of Clinical Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1291\/hypres.18.235","article-title":"A 12-month comparison of ACE inhibitor and CA antagonist therapy in mild to moderate essential hypertension - the GLANT Study","volume":"18","author":"Study Group on Long-term Antihypertensive Therapy","year":"1995","journal-title":"Hypertension Research"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/bmj.315.7101.154","article-title":"Randomised, double blind, multicenter comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study","volume":"315","author":"Phillip","year":"1997","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD008276.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00004872-198710000-00009","article-title":"Beta-blockers versus diuretics in hypertensive men: main results from the HAPPHY trial","volume":"5","author":"Wilhelmsen","year":"1987","journal-title":"Journal of Hypertension"},{"issue":"3","key":"10.1002\/14651858.CD008276.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/oxfordjournals.aje.a114008","article-title":"Detection and treatment of hypertension in older individuals","volume":"121","author":"Curb","year":"1985","journal-title":"American Journal of Epidemiology"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1001\/jama.1979.03300230018021","article-title":"Five-year findings of the Hypertension Detection and Follow-up Program: reduction in mortality in persons with high blood pressure, including mild hypertension","volume":"242","author":"Hypertension Detection and Follow-up Program Cooperative Group","year":"1979","journal-title":"JAMA"},{"issue":"3","key":"10.1002\/14651858.CD008276.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJM200001203420301","article-title":"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Outcomes Study Investigators","volume":"342","author":"Yusuf","year":"2000","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/08037059509077613","article-title":"The Hypertension Optimal Treatment (HOT) Study: 12-month data on blood pressure and tolerability. With special reference to age and gender","volume":"4","author":"Hansson","year":"1995","journal-title":"Blood Pressure"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1097\/00004872-200312000-00030","article-title":"Results of the pilot study for the Hypertension in the Very Elderly Trial","volume":"21","author":"Bulpitt","year":"2003","journal-title":"Journal of Hypertension"},{"issue":"18","key":"10.1002\/14651858.CD008276.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1056\/NEJMoa0801369","article-title":"Treatment of hypertension in patients 80 years of age or older","volume":"358","author":"Beckett","year":"2008","journal-title":"New England Journal of Medicine"},{"issue":"8","key":"10.1002\/14651858.CD008276.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1474-4422(08)70143-1","article-title":"Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial","volume":"7","author":"Peters","year":"2008","journal-title":"Lancet Neurology"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1056\/NEJMoa011489","article-title":"The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes","volume":"345","author":"Parving","year":"2001","journal-title":"New England Journal of Medicine"},{"issue":"Suppl 13","key":"10.1002\/14651858.CD008276.pub2-BIB0057|cit57","first-page":"S157","article-title":"INSIGHT: International Nifedipine GITS study: intervention as a goal in hypertension treatment","volume":"10","author":"Brown","year":"1996","journal-title":"Journal of Human Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0058|cit58","first-page":"2113","article-title":"Study population and treatment titration in the International Nifedepine GITS study: intervention as a goal in hypertension treatment (INSIGHT)","volume":"16","author":"Brown","year":"1998","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0140-6736(00)02527-7","article-title":"Morbidity and mortality in patients randomised to double-blind treatment with long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study","volume":"356","author":"Brown","year":"2000","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD008276.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00004872-198508000-00011","article-title":"Cardiovascular risk and risk factors in a randomized trial of treatment based on the beta-blocker oxprenolol: the International Prospective Primary Prevention Study in Hypertension (IPPPSH)","volume":"3","author":"IPPPSH Collaborative Group","year":"1985","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0140-6736(07)60669-2","article-title":"Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded end point morbidity-mortality study","volume":"369","author":"Mochizuki","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/14651858.CD008276.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1536\/ihj.22.75","article-title":"Prospective study on the treatment of mild hypertension in the aged","volume":"22","author":"Kuramoto","year":"1981","journal-title":"Japanese Heart Journal"},{"issue":"6","key":"10.1002\/14651858.CD008276.pub2-BIB0063|cit63","first-page":"S35","article-title":"Treatment of the elderly hypertensives in Japan: National Intervention Cooperative Study in Elderly Hypertensives. The National Intervention Cooperative Study Group","volume":"12","author":"Kuramoto","year":"1994","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1056\/NEJMoa011303","article-title":"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes","volume":"345","author":"Lewis","year":"2001","journal-title":"New England Journal of Medicine"},{"issue":"13","key":"10.1002\/14651858.CD008276.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1001\/jama.1988.03720130040027","article-title":"Primary prevention with metoprolol in patients with hypertension. Mortality results from the MAPHY study","volume":"259","author":"Wikstrand","year":"1988","journal-title":"JAMA"},{"issue":"13","key":"10.1002\/14651858.CD008276.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1056\/NEJM199304013281303","article-title":"Single-drug therapy for hypertension in men: a comparison of six antihypertensive agents with placebo","volume":"328","author":"Materson","year":"1993","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD008276.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0895-7061(94)00196-I","article-title":"Department of Veterans Affairs single-drug therapy of hypertension study. Revised figures and new data. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents","volume":"8","author":"Materson BJ. Reda","year":"1995","journal-title":"American Journal of Hypertension"},{"issue":"10","key":"10.1002\/14651858.CD008276.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/jama.1996.03540100029024","article-title":"Final outcome results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS)","volume":"276","author":"Borhani","year":"1996","journal-title":"JAMA"},{"issue":"1","key":"10.1002\/14651858.CD008276.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5694\/j.1326-5377.1980.tb131808.x","article-title":"Failure of therapy to improve prognosis in elderly males with hypertension","volume":"2","author":"Morgan","year":"1980","journal-title":"Medical Journal of Australia"},{"issue":"6824","key":"10.1002\/14651858.CD008276.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.304.6824.405","article-title":"Medical Research Council Trial of Treatment of Hypertension in Older Adults: principal results","volume":"304","author":"MRC Working Party","year":"1992","journal-title":"BMJ"},{"issue":"9227","key":"10.1002\/14651858.CD008276.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0140-6736(00)02526-5","article-title":"Randomised trial of effects of calcium antagonists compared with diuretics and beta-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study","volume":"356","author":"Hansson","year":"2000","journal-title":"Lancet"},{"issue":"9","key":"10.1002\/14651858.CD008276.pub2-BIB0072|cit72","first-page":"710","article-title":"Post-stroke antihypertensive treatment study. A preliminary result","volume":"108","author":"PATS Collaborating Group","year":"1995","journal-title":"Chinese Medical Journal"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(01)06178-5","article-title":"Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischemic attack","volume":"358","author":"PROGRESS Collaborative Group","year":"2001","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0002-9149(01)01461-8","article-title":"The QUinapril Ischemic Event Trial (QUIET): evaluation of chronic ACE inhibitor therapy in patients with ischemic heart disease and preserved left ventricular function","volume":"87","author":"Pitt","year":"2001","journal-title":"American Journal of Cardiology"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1161\/01.CIR.102.15.1748","article-title":"Long-term effects of cholesterol lowering and angiotensin converting enzyme inhibition on coronary atherosclerosis","volume":"102","author":"Teo","year":"2000","journal-title":"Circulation"},{"issue":"3","key":"10.1002\/14651858.CD008276.pub2-BIB0076|cit76","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1161\/CIRCULATIONAHA.107.750745","article-title":"Long-term antihypertensive efficacy and safety of the oral direct renin Inhibitor aliskiren. A 12-month randomized, double-blind comparator trial with hydrochlorothiazide","volume":"119","author":"Schmieder","year":"2009","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0077|cit77","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1097\/01.hjh.0000059028.82022.89","article-title":"The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial","volume":"21","author":"Lithell","year":"2003","journal-title":"Journal of Hypertension"},{"issue":"5","key":"10.1002\/14651858.CD008276.pub2-BIB0078|cit78","first-page":"S6206","article-title":"Systolic hypertension in the elderly: long-term lacidipine treatment. Objective, protocol, and organization. SHELL Study Group","volume":"23","author":"Malacco","year":"1994","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"24","key":"10.1002\/14651858.CD008276.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1001\/jama.1991.03460240051027","article-title":"Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP)","volume":"265","author":"SHEP Cooperative Research Group","year":"1991","journal-title":"JAMA"},{"issue":"12","key":"10.1002\/14651858.CD008276.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0895-4356(88)90024-8","article-title":"Rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension","volume":"41","author":"SHEP Cooperative Research Group","year":"1988","journal-title":"Journal of Clinical Epidemiology"},{"issue":"1","key":"10.1002\/14651858.CD008276.pub2-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/01.STR.20.1.4","article-title":"Morbidity and mortality in the Systolic Hypertension in the Elderly Program (SHEP) Pilot Study","volume":"20","author":"Perry","year":"1989","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/bmj.283.6300.1151","article-title":"Blood pressure reduction in the elderly: a randomised controlled trial of methyldopa","volume":"283","author":"Sprackling","year":"1981","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1097\/00004872-199610000-00013","article-title":"Shanghai Trial of Nifedipine in the Elderly (STONE) study","volume":"14","author":"Gong","year":"1996","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/0140-6736(91)92589-T","article-title":"Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOPHypertension)","volume":"338","author":"Dahl\u00f6f","year":"1991","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3109\/08037059309077541","article-title":"STOP-Hypertension-2: a prospective intervention trial of \"newer\" versus \"older\" treatment alternatives in old patients with hypertension","volume":"2","author":"Dahl\u00f6f","year":"1993","journal-title":"Blood Pressure"},{"issue":"9","key":"10.1002\/14651858.CD008276.pub2-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1001\/jama.1991.03470090059032","article-title":"Long-term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men","volume":"266","author":"Strandberg","year":"1991","journal-title":"JAMA"},{"issue":"5","key":"10.1002\/14651858.CD008276.pub2-BIB0087|cit87","first-page":"270-5, 323","article-title":"Systolic hypertension in the elderly: Chinese trial (Syst-China). Interim report","volume":"20","author":"Anonymous","year":"1992","journal-title":"Zhonghua Xin Xue Guan Bing za Zhi"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0088|cit88","first-page":"287","article-title":"Syst-Eur: a multicenter trial on the treatment of isolated systolic hypertension in the elderly; objectives, protocol and organisation","volume":"3","author":"Amery","year":"1991","journal-title":"Aging"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000107813","article-title":"Atenolol for secondary prevention after stroke","volume":"5","author":"Eriksson","year":"1995","journal-title":"Cerebrovascular Diseases (Basel, Switzerland)"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1006\/pmed.1995.1062","article-title":"Lifestyle intervention: results of the Treatment of Mild Hypertension Study (TOMHS)","volume":"24","author":"Elmer","year":"1995","journal-title":"Preventive Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/bmj.317.7160.713","article-title":"Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39","volume":"317","author":"UK Prospective Diabetes Study Group","year":"1998","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/bmj.317.7160.703","article-title":"Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38","volume":"317","author":"UK Prospective Diabetes Study Group","year":"1998","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0093|cit93","first-page":"133","article-title":"A double-blind control study of antihypertensive agents. I. Comparative effect of reserpine, reserpine and hydralazine, and three ganglionic blocking agents, clorisondamine, mecamylamine, and pentolinium tartrate","volume":"106","author":"Veterans Administration Cooperative Study Group on Antihypertensive Agents","year":"1960","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1001\/jama.1982.03330160052024","article-title":"Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II Results of long term therapy","volume":"248","author":"Veterans Administrative Cooperative Study Group on Antihypertensive Agents","year":"1982","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/archinte.1962.03620200090016","article-title":"A double-blind control study of antihypertensive agents. III. Chlorothiazide alone and in combination with other agents: preliminary results","volume":"110","author":"Veterans Administration Cooperative Study Group on Antihypertensive Agents","year":"1962","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/00004872-199715110-00019","article-title":"Clinical results of the verapamil in hypertension and atherosclerosis study","volume":"15","author":"Agabiti","year":"1997","journal-title":"Journal of Hypertension"},{"issue":"11","key":"10.1002\/14651858.CD008276.pub2-BIB0097|cit97","first-page":"879","article-title":"Long-term safety and efficacy of moexipril alone and in combination with hydrochlorothiazide in elderly patients with hypertension","volume":"9","author":"White","year":"1995","journal-title":"Journal of Human Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0021-9681(66)90128-7","article-title":"Effects of treatment in hypertension. Results of a controlled study","volume":"19","author":"Wolff","year":"1966","journal-title":"Journal of Chronic Diseases"},{"issue":"12","key":"10.1002\/14651858.CD008276.pub2-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1001\/archinte.165.12.1410","article-title":"Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospectively designed overviews of randomized trials","volume":"165","author":"Turnbull","year":"2005","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1472-8206.2005.00356.x","article-title":"Apparent effect on blood pressure is only partly responsible for the risk reduction due to antihypertensive treatments","volume":"19","author":"Boissel","year":"2005","journal-title":"Fundamental & Clinical Pharmacology"},{"issue":"7653","key":"10.1002\/14651858.CD008276.pub2-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/bmj.39548.738368.BE","article-title":"Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials","volume":"336","author":"Turnbull","year":"2008","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0140-6736(90)90944-Z","article-title":"Blood pressure, stroke, and coronary heart disease - Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context","volume":"335","author":"Collins","year":"1990","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD008276.pub2-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1586\/erc.10.27","article-title":"Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics","volume":"8","author":"Duarte","year":"2010","journal-title":"Expert Review of Cardiovascular Therapy"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0104|cit104","volume-title":"Current Cardiovascular Drugs","author":"Frishman","year":"2005"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0105|cit105","article-title":"GRADE handbook for grading quality of evidence and strength of recommendations","volume-title":"The GRADE Working Group, 2013","author":"Sch\u00fcnemann","year":"Updated October 2013"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0106|cit106","first-page":"353","article-title":"INDANA: a meta-analysis on individual patient data in hypertension. Protocol and preliminary results","volume":"50","author":"Gueyffier","year":"1995","journal-title":"Therapie"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0107|cit107","first-page":"1","article-title":"New meta-analysis of treatment trials of hypertension: improving the estimate of therapeutic benefit","volume":"10","author":"Gueyffier","year":"1996","journal-title":"Journal of Human Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0140-6736(98)08127-6","article-title":"Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials","volume":"353","author":"Gueyffier","year":"1999","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0109|cit109","unstructured":"Higgins JP Green S editor(s) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0110|cit110","unstructured":"Higgins JPT Altman DG Sterne JAC Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"4","key":"10.1002\/14651858.CD008276.pub2-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3317\/jraas.2004.034","article-title":"How do thiazide and thiazide-like diuretics lower blood pressure?\"","volume":"5","author":"Hughes","year":"2004","journal-title":"Journal of the Renin-Angiotensin-Aldosterone System"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"355","DOI":"10.7326\/0003-4819-121-5-199409010-00008","article-title":"Drug treatment of hypertension in the elderly: a meta-analysis","volume":"121","author":"Insua","year":"1994","journal-title":"Annals of Internal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD008276.pub2-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"issue":"2","key":"10.1002\/14651858.CD008276.pub2-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0149-2918(04)90024-0","article-title":"A systematic review and meta-analysis of the efficacy and safety of a fixed low-dose perindopril-indapamide combination as first-line treatment of hypertension","volume":"26","author":"Kang","year":"2004","journal-title":"Clinical Therapeutics"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/14651858.CD008276.pub2-BIB0116|cit116","first-page":"49","article-title":"Renin-angiotensin-aldosterone system blockers and cardiovascular outcomes: a meta-analysis of randomized clinical trials","volume":"45","author":"K\u0131z\u0131l\u0131rmak","year":"2017","journal-title":"Turk Kardiyoloji Dernegi Arsivi"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"b1665","DOI":"10.1136\/bmj.b1665","article-title":"Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies","volume":"338","author":"Law","year":"2009","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0118|cit118","volume-title":"Harrison's Principals of Internal Medicine","volume":"2","author":"Longo","year":"2012"},{"issue":"6","key":"10.1002\/14651858.CD008276.pub2-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3109\/10641969309037085","article-title":"The effects of blood pressure reduction in older patients: an overview of \ufb01ve randomized controlled trials in elderly hypertensives","volume":"15","author":"MacMahon","year":"1993","journal-title":"Clinical and Experimental Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0120|cit120","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/eurheartj\/eht151","article-title":"2013 ESH\/ESC guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"34","author":"Mancia","year":"2013","journal-title":"European Heart Journal"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1001\/jama.1994.03520240060042","article-title":"Hypertension in the elderly: Implications and generalizability of randomized trials","volume":"272","author":"Mulrow","year":"1994","journal-title":"JAMA"},{"issue":"2","key":"10.1002\/14651858.CD008276.pub2-BIB0122|cit122","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000028","article-title":"Pharmacotherapy for hypertension in the elderly","author":"Mulrow","year":"1998","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD008276.pub2-BIB0123|cit123","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000028.pub2","article-title":"Pharmacotherapy for hypertension in the elderly","author":"Musini","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0124|cit124","unstructured":"National Institute for Health and Care Excellence Treating high blood pressure with lifestyle changes, August 2011, updated November 2016 www.nice.org.uk\/guidance\/cg127\/ifp\/chapter\/treating-high-blood-pressure-with-lifestyle-changes"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s003910070015","article-title":"Treatment of arterial hypertension with diuretics, beta- and calcium channel blockers in old patients","volume":"33","author":"Nikolaus","year":"2000","journal-title":"Zeitschrift fur Gerontologie und Geriatrie"},{"issue":"2","key":"10.1002\/14651858.CD008276.pub2-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2217\/fca.15.90","article-title":"The effect of antihypertensive treatment on the incidence of stroke and cognitive decline in the elderly: a meta-analysis","volume":"12","author":"Parsons","year":"2016","journal-title":"Future Cardiology"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0127|cit127","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/archfami.4.11.943","article-title":"Does antihypertensive treatment of the elderly prevent cardiovascular events or prolong life? A meta-analysis of hypertension treatment trials","volume":"4","author":"Pearce","year":"1995","journal-title":"Archives of Family Medicine"},{"issue":"9349","key":"10.1002\/14651858.CD008276.pub2-BIB0128|cit128","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"issue":"9","key":"10.1002\/14651858.CD008276.pub2-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/jama.1997.03540330061036","article-title":"Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis","volume":"277","author":"Psaty","year":"1997","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1001\/jama.289.19.2534","article-title":"Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis","volume":"289","author":"Psaty","year":"2003","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1046\/j.1525-1497.1999.12198.x","article-title":"Efficacy of treating hypertension in women","volume":"14","author":"Quan","year":"1999","journal-title":"Journal of General Internal Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0132|cit132","unstructured":"Nordic Cochrane Centre, The Cochrane Collaboration Review Manager 2014"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0133|cit133","doi-asserted-by":"crossref","first-page":"184","DOI":"10.7326\/M14-0773","article-title":"Effects of blood pressure reduction in mild hypertension. A systematic review and meta-analysis","volume":"162","author":"Sundstr\u00f6m","year":"2015","journal-title":"Annals of Internal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD008276.pub2-BIB0134|cit134","first-page":"7624","article-title":"ACEIs\/ARBs for the prevention of type 2 diabetes in patients with cardiovascular diseases: a systematic review and meta-analysis","volume":"9","author":"Tan","year":"2016","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/00004872-199210000-00001","article-title":"A meta-analysis of outcome trials in elderly hypertensives","volume":"10","author":"Thijs","year":"1992","journal-title":"Journal of Hypertension"},{"issue":"12","key":"10.1002\/14651858.CD008276.pub2-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1097\/HJH.0000000000000378","article-title":"Effects of blood pressure lowering on outcome incidence in hypertension. 1. Overview, meta-analyses, and meta-regression analyses of randomized trials","volume":"32","author":"Thomopoulos","year":"2014","journal-title":"Journal of Hypertension"},{"issue":"3","key":"10.1002\/14651858.CD008276.pub2-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/HJH.0000000000000848","article-title":"Effects of blood pressure-lowering treatment. 6. Prevention of heart failure and new-onset heart failure - meta-analyses of randomized trials","volume":"34","author":"Thomopoulos","year":"2016","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0138|cit138","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(03)14739-3","article-title":"Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials","volume":"362","author":"Turnbull","year":"2003","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/14651858.CD008276.pub2-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/HJH.0000000000000065","article-title":"Clinical practice guidelines for the management of hypertension in the community. A statement by the American Society of Hypertension and the International Society of Hypertension","volume":"32","author":"Weber","year":"2014","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD008276.pub2-BIB0140|cit140","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/00004872-200311000-00002","article-title":"2003 World Health Organization\/International Society of Hypertension (ISH) statement on management of hypertension","volume":"21","author":"World Health Organization","year":"2003","journal-title":"Journal of Hypertension"},{"issue":"1","key":"10.1002\/14651858.CD008276.pub2-BIB0141|cit141","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002003.pub2","article-title":"Beta-blockers for hypertension","author":"Wiysonge","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD008276.pub2-BIB0142|cit142","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001841.pub2","article-title":"First-line drugs for hypertension","author":"Wright","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD008276.pub2-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.116.303641","article-title":"Randomized controlled trials of blood pressure lowering in hypertension: a critical reappraisal","volume":"116","author":"Zanchetti","year":"2015","journal-title":"Circulation Research"},{"issue":"1","key":"10.1002\/14651858.CD008276.pub2-BIB0144|cit144","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008276","article-title":"Pharmacotherapy for hypertension in non-elderly adults","author":"Musini","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD008276.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T03:17:55Z","timestamp":1723173475000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008276.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Hypertension Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":144,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008276.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]}}}