{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:05:01Z","timestamp":1783947901011,"version":"3.55.0"},"update-to":[{"DOI":"10.1002\/14651858.cd008280","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000}}],"reference-count":51,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008280.pub2","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T14:59:07Z","timestamp":1328885947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Interventions for atrophic rhinitis"],"prefix":"10.1002","volume":"2012","author":[{"given":"Anupam","family":"Mishra","sequence":"first","affiliation":[{"name":"King George Medical University; Department of Otolaryngology; Lucknow (UP) India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Kawatra","sequence":"additional","affiliation":[{"name":"Eras Medical College; Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Gola","sequence":"additional","affiliation":[{"name":"Fatima Hospital; Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"10.1002\/14651858.CD008280.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archotol.127.2.193","article-title":"Absence of nasal mucosal atrophy with fluticasone aqueous nasal spray","volume":"127","author":"Baroody","year":"2001","journal-title":"Archives of Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0140-6736(93)91329-K","article-title":"Ciprofloxacin for rhinoscleroma and ozena","volume":"342","author":"Borgstein","year":"1993","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0003|cit3","first-page":"122","article-title":"Application of endoscopic sinus surgery to primary atrophic rhinitis? A clinical trial","volume":"36","author":"Fang","year":"1998","journal-title":"Rhinology (Utrecht)"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00405-008-0629-5","article-title":"Novel treatment of atrophic rhinitis: early results","volume":"265","author":"Jaswal","year":"2008","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1001\/archotol.127.11.1353","article-title":"Pure sesame oil vs isotonic sodium chloride solution as treatment for dry nasal mucosa","volume":"127","author":"Johnsen","year":"2001","journal-title":"Archives of Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1055\/s-2007-997014","article-title":"Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior","volume":"77","author":"Kehrl","year":"1998","journal-title":"Laryngo-Rhino-Otologie"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0007|cit7","first-page":"19","article-title":"The effect of intranasal beclomethasone dipropionate on the nasal mucosa","volume":"18","author":"Klemi","year":"1980","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0008|cit8","first-page":"17","article-title":"Local safety of intranasal triamcinolone acetonide: clinical and histological aspects of nasal mucosa in the long-term treatment of perennial allergic rhinitis","volume":"39","author":"Klossek","year":"2001","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1034\/j.1398-9995.2000.00649.x","article-title":"Clinical and pathologic methods to assess the long-term safety of nasal corticosteroids","volume":"55","author":"Laliberte","year":"2000","journal-title":"Allergy"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0010|cit10","first-page":"310","article-title":"Pre and post-treatment histopathological changes in atrophic rhinitis","volume":"48","author":"Mehrotra","year":"2005","journal-title":"Indian Journal of Pathology and Microbiology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0011|cit11","first-page":"1533","article-title":"Autogenous bone versus beta-tricalcium phosphate graft alone for bilateral sinus elevations (2-3D CT, histologic and histomorphometric evaluations)","volume":"143","author":"Nemeth","year":"2002","journal-title":"Orvosi Hetilap"},{"issue":"2","key":"10.1002\/14651858.CD008280.pub2-BIB0012|cit12","first-page":"57","article-title":"Successful treatment of ozena with ciprofloxacin","volume":"33","author":"Nielsen","year":"1995","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1600-0501.2006.01303.x","article-title":"Clinical evaluation of demineralized bone allograft in a hyaluronic acid carrier for sinus lift augmentation in humans: a computed tomography and histomorphometric study","volume":"18","author":"Schwartz","year":"2007","journal-title":"Clinical Oral Implants Research"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0196-0709(96)90000-9","article-title":"Atrophic rhinitis","volume":"17","author":"Shehata","year":"1996","journal-title":"American Journal of Otolaryngology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0015|cit15","first-page":"183","article-title":"Results of inplacen treatment of ozena","volume":"53","author":"Stoll","year":"1958","journal-title":"Medizinische Klinik"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/(SICI)1097-4636(1999)48:6<869::AID-JBM16>3.0.CO;2-6","article-title":"Interactions between the bioactive glass S53P4 and the atrophic rhinitis-associated microorganism Klebsiella ozaenae","volume":"48","author":"Stoor","year":"1999","journal-title":"Journal of Biomedical Materials Research"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0017|cit17","unstructured":"Mishra A Effect of surgical vs. non-surgical management on olfactory status in primary atrophic rhinitis Indian Council of Medical Research"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0018|cit18","first-page":"43","article-title":"Atrophic rhinitis: an inherited condition","volume":"4","author":"Amreliwala","year":"1993","journal-title":"Indian Journal of Clinical Practice"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0019|cit19","first-page":"299","article-title":"Chronic atrophic rhinitis and Klebsiella ozaenae infection","volume":"18","author":"Artiles","year":"2000","journal-title":"Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1017\/S0022215100156506","article-title":"Histopathological and histochemical studies on atrophic rhinitis","volume":"84","author":"Barbary","year":"1970","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/bmj.3.5613.315","article-title":"Ozaena and iron deficiency","volume":"3","author":"Bernat","year":"1968","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0022|cit22","first-page":"125","article-title":"Characteristics of atrophic rhinitis in Thai patients at the Siriraj Hospital","volume":"37","author":"Bunnag","year":"1999","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0023|cit23","first-page":"529","article-title":"Scleroma of the upper respiratory tract and ozaena: clinicopathological correlations [Italian]","volume":"17","author":"Carducci","year":"1965","journal-title":"La Clinica Otorinolaringoiatrica"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0024|cit24","first-page":"119","article-title":"Atrophic rhinitis and nasal miasis","volume-title":"ENT Disorders in a Tropical Environment","author":"Chaturvedi","year":"1999"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0025|cit25","first-page":"461","article-title":"Analysis of nasal complications after radiotherapy in patients with nasopharyngeal carcinoma by logistic regression (in Chinese)","volume":"17","author":"Chen","year":"2003","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1258\/002221505774783377","article-title":"The etiology and management of atrophic rhinitis","volume":"119","author":"Dutt","year":"2005","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0027|cit27","first-page":"202","article-title":"Septal mucoperichondrial flap for closure of nostril in atrophic rhinitis","volume":"36","author":"Kholy","year":"1998","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1017\/S0022215100077793","article-title":"Modification in the technique of closure of the nostril","volume":"87","author":"Gadre","year":"1973","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF02994238","article-title":"Primary atrophic rhinitis. A new hypothesis for its etiopathogenesis","volume":"39","author":"Ghosh","year":"1987","journal-title":"Indian Journal of Otolaryngology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1017\/S0022215100120626","article-title":"Radiological and endoscopic study of maxillary sinus in primary atrophic rhinitis","volume":"106","author":"Hagrass","year":"1992","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0031|cit31","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1017\/S0022215100118092","article-title":"Fibreoptic endoscopy in atrophic rhinitis","volume":"105","author":"Kameswaran","year":"1991","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1017\/S0022215100141040","article-title":"Closure of the nasal vestibule in atrophic rhinitis \u2013 a new non-surgical technique","volume":"112","author":"Lobo","year":"1998","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0034|cit34","first-page":"373","article-title":"Immunoglobin content and T cell activity according to rosette cell in ozaena","volume":"33","author":"Makowska","year":"1979","journal-title":"Otolaryngologia Polska"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00405-002-0571-x","article-title":"Clinical, genetic and immunological analysis of a family affected by ozaena","volume":"260","author":"Medina","year":"2003","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0036|cit36","first-page":"11","article-title":"Evolution of nasal mucosa lesions in leprosy (histological study)","volume":"53","author":"Mehta","year":"1981","journal-title":"Leprosy in India"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0037|cit37","first-page":"277","article-title":"Assessment of nasal mucosa in workers exposed to the prolonged effect of phosphorite and apatite dusts","volume":"6","author":"Mickiewicz","year":"1993","journal-title":"Polish Journal of Occupational Medicine and Environmental Health"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/194589240101500601","article-title":"Atrophic rhinitis: a review of 242 cases","volume":"15","author":"Moore","year":"2001","journal-title":"American Journal of Rhinology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1055\/s-2007-997300","article-title":"Ozaena and allergic rhinitis in ichthyosis vulgaris [German]","volume":"71","author":"Reisser","year":"1992","journal-title":"Laryngorhinootologie"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0040|cit40","unstructured":"The Nordic Cochrane Centre. The Cochrane Collaboration Review Manager (RevMan) 2011"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1001\/archotol.1932.03570030239005","article-title":"A differential diagnosis and therapy of atrophic rhinitis and ozaena","volume":"15","author":"Ruskin","year":"1932","journal-title":"Archives of Otolaryngology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1258\/0022215001905508","article-title":"Study of surfactant level in cases of primary atrophic rhinitis","volume":"114","author":"Sayed","year":"2000","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"287","DOI":"10.5694\/j.1326-5377.1992.tb137169.x","article-title":"Atrophic rhinitis - an unusual complication of typhoid fever","volume":"157","author":"Singh","year":"1992","journal-title":"Medical Journal of Australia"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1017\/S0022215100084097","article-title":"A nine years review of 273 cases of atrophic rhinitis and its management","volume":"91","author":"Sinha","year":"1977","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0045|cit45","first-page":"1105","article-title":"Anhidrotic ectodermal dysplasia presenting as atrophic rhinitis and maggots","volume":"40","author":"Sinha","year":"2003","journal-title":"Indian Pediatrics"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1017\/S0022215100058138","article-title":"Histopathological and histochemical studies on atrophic rhinitis","volume":"75","author":"Taylor","year":"1961","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0047|cit47","first-page":"4:4,8,26","article-title":"Infective rhinitis and sinusitis","volume-title":"Scott Brown\u2019s Otolaryngology","author":"Weir","year":"1997"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0048|cit48","first-page":"641","article-title":"Osteochondroplastic tracheobronchopathy - relations to rhinitis atrophica and iron deficiency [Polish]","volume":"61","author":"Wiatr","year":"1993","journal-title":"Pneumonologia i Alergologia Polska"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0049|cit49","first-page":"552","article-title":"The clinical features of human immunodeficiency virus (HIV) of ear, nose, throat, head and neck [Chinese]","volume":"13","author":"Xu","year":"1999","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0050|cit50","first-page":"452","article-title":"On the etiology of systemic ozaena [Polish]","volume":"47","author":"Zakrzewski","year":"1993","journal-title":"Otolaryngologia Polska"},{"key":"10.1002\/14651858.CD008280.pub2-BIB0051|cit51","first-page":"345","article-title":"Ozena revisited","volume":"19","author":"Zohar","year":"1990","journal-title":"Journal of Otolaryngology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD008280.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:17:57Z","timestamp":1783945077000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008280.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane ENT Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,15]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008280.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,15]]}}}