{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:24:26Z","timestamp":1776237866252,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd008424","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T00:00:00Z","timestamp":1350432000000}}],"reference-count":45,"publisher":"Wiley","issue":"6","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008424.pub2","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T13:19:26Z","timestamp":1349961566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Curcumin for maintenance of remission in ulcerative colitis"],"prefix":"10.1002","volume":"2013","author":[{"given":"Sushil K","family":"Garg","sequence":"first","affiliation":[{"name":"University of Minnesota; Department of Surgery; 420 Delaware Street SE Mayo Mail Code 195 Minneapolis USA 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineet","family":"Ahuja","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences; Department of Gastroenterology; Ansari Nagar New Delhi India 110029"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari Jeeva","family":"Sankar","sequence":"additional","affiliation":[{"name":"ICMR Center for Advanced Research in Newborn Health, WHO Collaborating Centre for Training and Research in Newborn Care, All India Institute of Medical Sciences; Department of Pediatrics; New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Kumar","sequence":"additional","affiliation":[{"name":"VA Medical Center - Northport; Gastroenterology and Hepatology; 79 Middleville Road Northport New York USA 11768"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan C","family":"Moss","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center; Center for Inflammatory Bowel Disease; Rabb\/Rose 1, East Brookline Ave Boston MA USA 02215"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,17]]},"reference":[{"issue":"12","key":"10.1002\/14651858.CD008424.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.cgh.2006.08.008","article-title":"Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial","volume":"4","author":"Hanai","year":"2006","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"1","key":"10.1002\/14651858.CD008424.pub2-BIB0002|cit2","first-page":"S133","article-title":"Evaluation of efficacy and safety of induction therapy with curcumin enema in ulcerative colitis patients with mild to moderate proctitis","volume":"5","author":"Ahuja","year":"2011","journal-title":"Journal of Crohn's and Colitis"},{"issue":"4 Suppl 1","key":"10.1002\/14651858.CD008424.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"A205","DOI":"10.1016\/S0016-5085(03)81031-4","article-title":"A double blind,placebo controlled randomised trial of curcuma extract in the treatment of steroid dependent inflammatory bowel disease","volume":"124","author":"Atkinson","year":"2003","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1002\/14651858.CD008424.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1007\/s10620-005-3032-8","article-title":"Curcumin therapy in inflammatory bowel disease: a pilot study","volume":"50","author":"Holt","year":"2005","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1002\/14651858.CD008424.pub2-BIB0005|cit5","unstructured":"NCT00889161 Curcumin in pediatric inflammatory bowel disease http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00889161"},{"issue":"1","key":"10.1002\/14651858.CD008424.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2006-960004","article-title":"Pharmacology of Curcuma longa","volume":"57","author":"Ammon","year":"1991","journal-title":"Planta Medica"},{"issue":"6","key":"10.1002\/14651858.CD008424.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"1311\u20137","DOI":"10.1016\/j.fct.2009.03.003","article-title":"Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model","volume":"47","author":"Arafa","year":"2009","journal-title":"Food and Chemical Toxicology"},{"issue":"6","key":"10.1002\/14651858.CD008424.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/BF03401744","article-title":"Curcumin is an in vivo inhibitor of angiogenesis","volume":"4","author":"Arbiser","year":"1998","journal-title":"Molecular Medicine"},{"issue":"5","key":"10.1002\/14651858.CD008424.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s00467-004-1411-6","article-title":"Interstitial nephritis from mesalazine: case report and literature review","volume":"19","author":"Arend","year":"2004","journal-title":"Pediatric Nephrology"},{"issue":"3","key":"10.1002\/14651858.CD008424.pub2-BIB0010|cit10","first-page":"134","article-title":"Status of alternative medicine in Crohn disease and ulcerative colitis patents: a questionnaire survey","volume":"12","author":"Ausfeld-Hafter","year":"2005","journal-title":"Forschende Komplementarmedizin und klassische Naturheilkunde"},{"issue":"10","key":"10.1002\/14651858.CD008424.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.bcp.2009.06.105","article-title":"Curcumin derivatives: molecular basis of their anti-cancer activity","volume":"78","author":"Basile","year":"2009","journal-title":"Biochemical Pharmacology"},{"issue":"4","key":"10.1002\/14651858.CD008424.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jama.289.4.454","article-title":"Scope and impact of financial conflicts of interest in biomedical research: a systematic review","volume":"289","author":"Bekelman","year":"2003","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD008424.pub2-BIB0013|cit13","volume-title":"The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines","author":"Blumenthal","year":"1998"},{"issue":"6","key":"10.1002\/14651858.CD008424.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0895-4356(97)00049-8","article-title":"The results of direct and indirect treatment comparisons in meta- analysis of randomized controlled trials","volume":"50","author":"Bucher","year":"1997","journal-title":"Journal of Clinical Epidemiology"},{"issue":"1","key":"10.1002\/14651858.CD008424.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/107555303321223035","article-title":"Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)","volume":"9","author":"Chainani-Wu","year":"2003","journal-title":"Journal of Alternative and Complementary Medicine"},{"issue":"11","key":"10.1002\/14651858.CD008424.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/0006-2952(95)00171-U","article-title":"Inhibition of tumor necrosis factor by curcumin, a phytochemical","volume":"49","author":"Chan","year":"1995","journal-title":"Biochemical Pharmacology"},{"issue":"4B","key":"10.1002\/14651858.CD008424.pub2-BIB0017|cit17","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Research"},{"issue":"10","key":"10.1002\/14651858.CD008424.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/jama.1990.03440100097014","article-title":"The existence of publication bias and risk factors for its occurrence","volume":"263","author":"Dickersin","year":"1990","journal-title":"JAMA"},{"issue":"7109","key":"10.1002\/14651858.CD008424.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"629\u201334","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD008424.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ncpgasthep0031","article-title":"Update on the etiology, pathogenesis and diagnosis of ulcerative colitis","volume":"1","author":"Hanauer","year":"2004","journal-title":"Nature Clinical Practice. Gastroenterology and Hepatology"},{"key":"10.1002\/14651858.CD008424.pub2-BIB0021|cit21","article-title":"Chapter 8: Assessing risk of bias in included studies","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","author":"Higgins","year":"2011. Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD008424.pub2-BIB0022|cit22","article-title":"Chapter 9: Analysing data and undertaking meta-analyses","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","author":"Deeks","year":"2011. Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD008424.pub2-BIB0023|cit23","article-title":"Chapter 7: Selecting studies and collecting data","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","author":"Higgins","year":"2011. Available from www.cochrane-handbook.org"},{"issue":"9","key":"10.1002\/14651858.CD008424.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/carcin\/bgh165","article-title":"Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase","volume":"25","author":"Hong","year":"2004","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1002\/14651858.CD008424.pub2-BIB0025|cit25","first-page":"813","article-title":"Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis","volume":"51","author":"Huang","year":"1991","journal-title":"Cancer Research"},{"issue":"6","key":"10.1002\/14651858.CD008424.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.163.6.3474","article-title":"Curcumin blocks cytokine-mediated NF-kappa B activation and pro inflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity","volume":"163","author":"Jobin","year":"1999","journal-title":"Journal of Immunology"},{"key":"10.1002\/14651858.CD008424.pub2-BIB0027|cit27","first-page":"62","volume-title":"Dictionary of Economic Plants in India","author":"Joshi","year":"1983"},{"issue":"1","key":"10.1002\/14651858.CD008424.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0304-3835(94)90413-8","article-title":"Curcumin inhibit TPA-induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin","volume":"87","author":"Kakar","year":"1994","journal-title":"Cancer Letters"},{"issue":"3","key":"10.1002\/14651858.CD008424.pub2-BIB0029|cit29","first-page":"597","article-title":"Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion\/progression stages of colon cancer","volume":"59","author":"Kawamori","year":"1999","journal-title":"Cancer Research"},{"key":"10.1002\/14651858.CD008424.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1749-6632.2009.04699.x","article-title":"Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells","volume":"1171","author":"Lee","year":"2009","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"9","key":"10.1002\/14651858.CD008424.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1038\/sj.bjc.6605308","article-title":"Curcumin induces apoptosis-independent death in oesophageal cancer cells","volume":"101","author":"O'Sullivan-Coyne","year":"2009","journal-title":"British Journal of Cancer"},{"issue":"4","key":"10.1002\/14651858.CD008424.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/MCG.0b013e3181cadbe1","article-title":"Pancreatitis in inflammatory bowel diseases","volume":"44","author":"Pitchumoni","year":"2010","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"13","key":"10.1002\/14651858.CD008424.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJM199109263251306","article-title":"Inflammatory Bowel Disease","volume":"325","author":"Podolosky","year":"1991","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD008424.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0300-483X(80)90122-5","article-title":"Absorption and tissue distribution of curcumin in rats","volume":"16","author":"Ravindranath","year":"1980","journal-title":"Toxicology"},{"issue":"5","key":"10.1002\/14651858.CD008424.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/sim.2971","article-title":"Arcsine test for publication bias in meta-analyses with binary outcomes","volume":"27","author":"R\u00fccker","year":"2008","journal-title":"Statistics in Medicine"},{"issue":"1","key":"10.1002\/14651858.CD008424.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"G235","DOI":"10.1152\/ajpgi.00449.2002","article-title":"Curcumin attenuates DNB-induced murine colitis","volume":"285","author":"Salh","year":"2003","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1002\/14651858.CD008424.pub2-BIB0037|cit37","article-title":"Chapter 12: Interpreting results and drawing conclusions","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","author":"Sch\u00fcnemann","year":"2011. Available from\u00a0www.cochrane-handbook.org"},{"issue":"42","key":"10.1002\/14651858.CD008424.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"24995","DOI":"10.1074\/jbc.270.42.24995","article-title":"Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]","volume":"270","author":"Singh","year":"1995","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1002\/14651858.CD008424.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.2042-7158.1997.tb06761.x","article-title":"Nitric oxide scavenging by curcuminoids","volume":"49","author":"Sreejayana","year":"1997","journal-title":"Journal of Pharmacy and Pharmacology"},{"issue":"6","key":"10.1002\/14651858.CD008424.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1053\/gast.2002.37050","article-title":"Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice","volume":"123","author":"Sugimoto","year":"2002","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1002\/14651858.CD008424.pub2-BIB0041|cit41","first-page":"152","article-title":"Curcumin for inflammatory bowel disease: a review of human studies","volume":"16","author":"Taylor","year":"2011","journal-title":"Alternative Medicine Review"},{"issue":"2","key":"10.1002\/14651858.CD008424.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.bjp.0705241","article-title":"Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitorobenzene sulfonic acid-induced colitis","volume":"139","author":"Ukil","year":"2003","journal-title":"British Journal of Pharmacology"},{"issue":"5","key":"10.1002\/14651858.CD008424.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s10620-009-0843-z","article-title":"Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti-inflammatory effect in the IL-10 gene-deficient mouse model of IBD","volume":"55","author":"Ung","journal-title":"Digestive Diseases and Sciences"},{"issue":"1","key":"10.1002\/14651858.CD008424.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1590\/S0004-28032009000100009","article-title":"Incidence and prevalence rates of inflammatory bowel diseases, in midwestern of S\u00e3o Paulo State, Brazil","volume":"46","author":"Victoria","year":"2009","journal-title":"Arquivos de Gastroenterologia"},{"issue":"2","key":"10.1002\/14651858.CD008424.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-0773.1978.tb02240.x","article-title":"A study on the fate of curcumin in the rat","volume":"43","author":"Wahlstrom","year":"1978","journal-title":"Acta Pharmacologica et Toxicologica"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD008424.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:31:42Z","timestamp":1776234702000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008424.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane IBD Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,10,17]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008424.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,17]]}}}