{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:17:25Z","timestamp":1790493445074,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd008864","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000}}],"reference-count":105,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008864.pub2","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T08:12:31Z","timestamp":1377763951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Fibrinogen concentrate in bleeding patients"],"prefix":"10.1002","volume":"2018","author":[{"given":"Anne","family":"Wikkels\u00f8","sequence":"first","affiliation":[{"name":"Hvidovre Hospital, University of Copenhagen; Department of Anaesthesiology and Intensive Care Medicine; Ketteg\u00e5rd Alle 30, Hvidovre Denmark 2650"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Lunde","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital; Juliane Marie Centre - Anaesthesia and Surgical Clinic Department 4013; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Johansen","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital; Juliane Marie Centre - Anaesthesia and Surgical Clinic Department 4013; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Stensballe","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet; Department of Anaesthesiology, Centre of Head and Orthopaedics & Section for Transfusion Medicine, Capital Region Blood Bank; Blegdamsvej 9 Copenhagen Denmark DK-2100 KBH \u00d8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Wetterslev","sequence":"additional","affiliation":[{"name":"Department 7812, Rigshospitalet, Copenhagen University Hospital; Copenhagen Trial Unit, Centre for Clinical Intervention Research; Blegdamsvej 9 Copenhagen Denmark DK-2100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Merete","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Herlev and Gentofte Hospital, University of Copenhagen; Cochrane Anaesthesia, Critical and Emergency Care Group; Herlev Ringvej Herlev Denmark 2730"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Afshari","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital; Juliane Marie Centre - Anaesthesia and Surgical Clinic Department 4013; Copenhagen Denmark"},{"name":"Rigshospitalet, Copenhagen University Hospital; Juliane Marie Centre, Department of Anaesthesiology; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"issue":"11","key":"10.1002\/14651858.CD008864.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"955-60","DOI":"10.1111\/j.1525-1594.2010.01148.x","article-title":"Perioperative monitoring of thromboelastograph on blood protection and recovery for severely cyanotic patients undergoing complex cardiac surgery","volume":"34","author":"Cui","year":"2010","journal-title":"Artificial Organs"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1538-7836.2009.03331.x","article-title":"Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial","volume":"7","author":"Fenger-Eriksen","year":"2009","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD008864.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"P438\u00a0","DOI":"10.1186\/cc11045","article-title":"Randomized comparison of fibrinogen concentrate versus cryoprecipitate for bleeding control in pediatric cardiac surgery (FICCS study)","volume":"16","author":"Galas","year":"2012","journal-title":"Critical Care"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1160\/TH08-09-0587","article-title":"Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study","volume":"102","author":"Karlsson","year":"2009","journal-title":"Thrombosis and Haemostasis"},{"issue":"4","key":"10.1002\/14651858.CD008864.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/1076029610366437","article-title":"Prophylactic fibrinogen Infusion in cardiac surgery patients: effects on biomarkers of coagulation, fibrinolysis, and platelet function","volume":"17","author":"Karlsson","year":"2011","journal-title":"Clinical and Applied Thrombosis\/Hemostasis"},{"issue":"1","key":"10.1002\/14651858.CD008864.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1423-0410.2011.01575.x","article-title":"Perioperative dilutional coagulopathy treated with fresh frozen plasma and fibrinogen concentrate: a prospective randomized intervention trial","volume":"103","author":"Lance","year":"2012","journal-title":"Vox Sanguinis"},{"issue":"1","key":"10.1002\/14651858.CD008864.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/ALN.0b013e3182715d4d","article-title":"Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial","volume":"118","author":"Rahe-Meyer","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0008|cit8","unstructured":"Rahe-Meyer N Solomon C Hanke A Schmidt DS Pichlmaier M Efficacy and safety of fibrinogen concentrate in the treatment of major bleeding during cardiac surgery: results of a randomized, placebo-controlled trial. No. LBC07 American Society of Anesthesiologists Annual Meeting, october 15-19, 2011; Chicago Illinois, USA"},{"issue":"2","key":"10.1002\/14651858.CD008864.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ijoa.2009.08.004","article-title":"The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage","volume":"19","author":"Bell","year":"2010","journal-title":"International Journal of Obstetrical Anesthesiology"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1423-0410.2007.01024.x","article-title":"Efficacy and tolerability of human fibrinogen concentrate administration to patients with acquired fibrinogen deficiency and active or in high-risk severe bleeding","volume":"94","author":"Dan\u00e9s","year":"2008","journal-title":"Vox Sanguinis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/j.1365-2044.2010.06548.x","article-title":"Fibrinogen concentrate use during major obstetric haemorrhage","volume":"65","author":"Glover","year":"2010","journal-title":"Anaesthesia"},{"issue":"3","key":"10.1002\/14651858.CD008864.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0034-9356(09)70356-1","article-title":"[Postpartum hemorrhage: an observational study of 21,726 deliveries in 28 months]","volume":"56","author":"Guasch","year":"2009","journal-title":"Revista Espanola de Anestesiologia y Reanimacion"},{"issue":"3","key":"10.1002\/14651858.CD008864.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"725-31, table o","DOI":"10.1213\/ane.0b013e318163fb26","article-title":"Fibrinogen in craniosynostosis surgery","volume":"106","author":"Haas","year":"2008","journal-title":"Anesthesia and Analgesia"},{"issue":"4","key":"10.1002\/14651858.CD008864.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1213\/01.ane.0000280481.18570.27","article-title":"Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration","volume":"105","author":"Mittermayr","year":"2007","journal-title":"Anesthesia and Analgesia"},{"issue":"4","key":"10.1002\/14651858.CD008864.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1053\/j.jvca.2011.07.008","article-title":"Fibrinogen concentrate therapy guided by thromboelastometry as an alternative to fresh frozen plasma in major vascular surgery","volume":"26","author":"Morrison","year":"2012","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"issue":"6","key":"10.1002\/14651858.CD008864.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/bja\/aep089","article-title":"Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study","volume":"102","author":"Rahe-Meyer","year":"2009","journal-title":"British Journal of Anaesthesia"},{"issue":"3","key":"10.1002\/14651858.CD008864.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jtcvs.2008.11.065","article-title":"Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery","volume":"138","author":"Rahe-Meyer","year":"2009","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"2","key":"10.1002\/14651858.CD008864.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2044.2009.06188.x","article-title":"Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate","volume":"65","author":"Schochl","year":"2010","journal-title":"Anaesthesia"},{"issue":"2","key":"10.1002\/14651858.CD008864.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/cc8948","article-title":"Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate","volume":"14","author":"Schochl","year":"2010","journal-title":"Critical Care (London, England)"},{"issue":"5","key":"10.1002\/14651858.CD008864.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/bja\/aeq058","article-title":"Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery","volume":"104","author":"Solomon","year":"2010","journal-title":"British Journal of Anaesthesia"},{"issue":"9","key":"10.1002\/14651858.CD008864.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1399-6576.2010.02289.x","article-title":"Effects of fibrinogen concentrate administration during severe hemorrhage","volume":"54","author":"Thorarinsdottir","year":"2010","journal-title":"Acta Anaesthesiologica Scandinavica"},{"issue":"3","key":"10.1002\/14651858.CD008864.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-3148.2008.00854.x","article-title":"Fibrinogen concentrate for acquired hypofibrinogenaemic states","volume":"18","author":"Weinkove","year":"2008","journal-title":"Transfusion Medicine (Oxford, England)"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"S156","DOI":"10.1186\/cc11045","article-title":"Randomized comparison of fibrinogen concentrate versus cryoprecipitate for bleeding control in pediatric cardiac surgery (FICCS study)","volume":"16","author":"Galas","year":"2012","journal-title":"Critical Care"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/S0049-3848(12)70005-1","article-title":"Fibrinogen Concentrate in the Treatment of Severe Bleeding After Aortic Aneurysm Graft Surgery","volume":"128","author":"Rahe-Meyer","year":"2011","journal-title":"Thrombosis Research"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0025|cit25","first-page":"ii86","article-title":"Haemostatic therapy with fibrinogen concentrate for controlling major bleeding during complex cardiovascular surgery: Results of a randomised, placebo-controlled trial","volume":"108","author":"Rahe-Meyer","year":"2012","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1016\/j.jtcvs.2012.12.083","article-title":"Fibrinogen concentrate reduces intraoperative bleeding when used as first-line hemostatic therapy during major aortic replacement surgery: Results from a randomized, placebo-controlled trial","volume":"145","author":"Rahe-Meyer","year":"2013","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0027|cit27","first-page":"e7","article-title":"Fibrinogen concentrate as first-line haemostatic therapy during aortic replacement surgery. A randomised trial","volume":"10","author":"Solomon","year":"2012","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0028|cit28","unstructured":"Fibrinogen Concentrate (FGTW) in Trauma Patients, Presumed to Bleed (FI in TIC) Ongoing study October 2011"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0029|cit29","unstructured":"Fibrinogen for Treatment of Pediatric Dilutional Coagulopathy: FibPaed Study Ongoing study January 2012"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0030|cit30","unstructured":"RETIC Trial: Reversal of Trauma Induced Coagulopathy Using Coagulation Factor Concentrates or Fresh Frozen Plasma Ongoing study March 2012"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0031|cit31","unstructured":"Fibrinogen and Bleeding After Cardiac Surgery (Fibro-3) Ongoing study April 2009"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0032|cit32","unstructured":"Prospective Double Blinded Randomized Control Study of the Use of\u00a0Fibrinogen\u00a0in High-Risk Cardiac Surgery Ongoing study"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0033|cit33","unstructured":"Haemocomplettan \u00ae P During Elective Complex Cardiac Surgery Ongoing study February 2011"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0034|cit34","unstructured":"Fibrinogen as an Alternative to Fresh Frozen Plasma in Aortic Surgery Ongoing study October 2009"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0035|cit35","unstructured":"The ZEro PLASma Trial (ZEPLAST): Avoidance of Fresh Frozen Plasma in Cardiac Surgery Ongoing study November 2011"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0036|cit36","unstructured":"The Efficacy of the Administration of Fibrinogen in Liver Transplantation (FibstudLT) Ongoing study March 2012"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0037|cit37","unstructured":"RiaSTAP vs. Conventional Transfusion in Patients Having Heart Valve Surgery (RiaCT) Ongoing study January 2011"},{"issue":"1","key":"10.1002\/14651858.CD008864.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1745-6215-13-110","article-title":"The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial","volume":"13","author":"Wikkelsoe","year":"2012","journal-title":"Trials"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/00000542-200607000-00030","article-title":"Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies","volume":"105","author":"The American Society of Anesthesiologists","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1160\/TH04-12-0799","article-title":"Relationship between factor XIII activity, fibrinogen, haemostasis screening tests and postoperative bleeding in cardiopulmonary bypass surgery","volume":"93","author":"Blome","year":"2005","journal-title":"Thrombosis and Haemostasis"},{"issue":"5","key":"10.1002\/14651858.CD008864.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2516.2004.00944.x","article-title":"The rare coagulation disorders\uff0dreview with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation","volume":"10","author":"Bolton-Maggs","year":"2004","journal-title":"Haemophilia"},{"issue":"9","key":"10.1002\/14651858.CD008864.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/j.1538-7836.2011.04424.x","article-title":"Fibrinogen replacement therapy for congenital fibrinogen deficiency","volume":"9","author":"Bornikova","year":"2011","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"1529-8809 (Elec","key":"10.1002\/14651858.CD008864.pub2-BIB0043|cit43","first-page":"1211","article-title":"Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis","volume":"64","author":"Brohi","year":"2008","journal-title":"The Journal of Trauma"},{"issue":"8","key":"10.1002\/14651858.CD008864.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jclinepi.2007.10.007","article-title":"Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses","volume":"61","author":"Brok","year":"2008","journal-title":"Journal of Clinical Epidemiology"},{"issue":"26","key":"10.1002\/14651858.CD008864.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1056\/NEJMoa1012452","article-title":"Liberal or restrictive transfusion in high-risk patients after hip surgery","volume":"365","author":"Carson","year":"2011","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD008864.pub2-BIB0046|cit46","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002042.pub3","article-title":"Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion","author":"Carson","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD008864.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1537-2995.2008.02021.x","article-title":"Comparison of coagulation factor XIII content and concentration in cryoprecipitate and fresh-frozen plasma","volume":"49","author":"Caudill","year":"2009","journal-title":"Transfusion"},{"issue":"20","key":"10.1002\/14651858.CD008864.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1001\/jama.291.20.2457","article-title":"Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles","volume":"291","author":"Chan","year":"2004","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1538-7836.2007.02297.x","article-title":"The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage","volume":"5","author":"Charbit","year":"2007","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"0340-6245 (Prin","key":"10.1002\/14651858.CD008864.pub2-BIB0050|cit50","first-page":"286","article-title":"Impaired haemostasis by intravenous administration of a gelatin-based plasma expander in human subjects","volume":"79","author":"Jonge","year":"1998","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/bja\/aei052","article-title":"Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes: improvements of the induced coagulopathy with fibrinogen concentrate","volume":"94","author":"Fenger-Eriksen","year":"2005","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/bja\/aen270","article-title":"Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations","volume":"101","author":"Fenger-Eriksen","year":"2008","journal-title":"British Journal of Anaesthesia"},{"issue":"10","key":"10.1002\/14651858.CD008864.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1517\/14712590903193051","article-title":"Fibrinogen concentrate\uff0da potential universal hemostatic agent","volume":"9","author":"Fenger-Eriksen","year":"2009","journal-title":"Expert Opinion on Biological Therapy"},{"issue":"7","key":"10.1002\/14651858.CD008864.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1538-7836.2009.03460.x","article-title":"Mechanisms of hydroxyethyl starch induced dilutional coagulopathy","volume":"7","author":"Fenger-Eriksen","year":"2009","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/bja\/aei160","article-title":"Effect of fibrinogen on reversal of dilutional coagulopathy: a porcine model","volume":"95","author":"Fries","year":"2005","journal-title":"British Joural of Anaesthesia"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/bja\/ael191","article-title":"Efficacy of fibrinogen and prothrombin complex concentrate used to reverse dilutional coagulopathy\uff0da porcine model","volume":"97","author":"Fries","year":"2006","journal-title":"British Journal of Anaesthesia"},{"issue":"2","key":"10.1002\/14651858.CD008864.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/bja\/aeq161","article-title":"Role of fibrinogen in trauma-induced coagulopathy","volume":"105","author":"Fries","year":"2010","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0058|cit58","unstructured":"GradePro Working Team GRADEPro 2008, http:\/\/ims.cochrane.org\/revman\/other-resources\/gradepro\/download"},{"issue":"1468-5833 (Elec","key":"10.1002\/14651858.CD008864.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/bmj.39490.551019.BE","article-title":"What is \"quality of evidence\" and why is it important to clinicians?","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1213\/01.ane.0b013e3181684339","article-title":"The in vitro effects of fibrinogen concentrate, factor XIII and fresh frozen plasma on impaired clot formation after 60% dilution","volume":"106","author":"Haas","year":"2008","journal-title":"Anesthesia and Analgesia"},{"issue":"6","key":"10.1002\/14651858.CD008864.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM199902113400601","article-title":"A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group","volume":"340","author":"Hebert","year":"1999","journal-title":"The New England Journal of Medicine"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0062|cit62","unstructured":"Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] The Cochrane Collaboration, 2011. www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0063|cit63","first-page":"360","article-title":"Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates","volume":"81","author":"Hiippala","year":"1995","journal-title":"Anesthesia and Analgesia"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/00001721-199512000-00008","article-title":"Dextran and hydroxyethyl starch interfere with fibrinogen assays","volume":"6","author":"Hiippala","year":"1995","journal-title":"Blood Coagulation & Fibrinolysis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1471-0528.2009.02187.x","article-title":"Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry","volume":"116","author":"Huissoud","year":"2009","journal-title":"British Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/1467-9876.00197","article-title":"Bias in meta-analysis due to outcome variable selection within studies","volume":"49","author":"Hutton","year":"2000","journal-title":"Journal of the Royal Statistical Society Series C"},{"issue":"15","key":"10.1002\/14651858.CD008864.pub2-BIB0067|cit67","first-page":"1905","article-title":"Statistical principles for clinical trials. International Conference on Harmonisation E9 Expert Working Group","volume":"18","author":"ICH Harmonised Tripartite","year":"1999","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"b1778","DOI":"10.1136\/bmj.b1778","article-title":"Damage control resuscitation for patients with major trauma","volume":"338","author":"Jansen","year":"2009","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/MBC.0b013e32830ef90c","article-title":"Rotational thromboelastography for monitoring of fibrinogen concentrate therapy in fibrinogen deficiency","volume":"19","author":"Kalina","year":"2008","journal-title":"Blood Coagulation & Fibrinolysis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1111\/j.1537-2995.2008.01827.x","article-title":"Plasma fibrinogen level, bleeding, and transfusion after on-pump coronary artery bypass grafting surgery: a prospective observational study","volume":"48","author":"Karlsson","year":"2008","journal-title":"Transfusion"},{"issue":"5","key":"10.1002\/14651858.CD008864.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"R239","DOI":"10.1186\/cc10488","article-title":"Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review","volume":"15","author":"Kozek-Langenecker","year":"2011","journal-title":"Critical Care (London, England)"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0072|cit72","doi-asserted-by":"crossref","unstructured":"Kozek-Langenecker S Sorensen B Hess J Spahn DR Emotional or evidence-based medicine\uff0dis there a moral tragedy in haemostatic therapy? Critical Care (London, England) 2011 462","DOI":"10.1186\/cc10583"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.transci.2004.04.003","article-title":"Pharmacokinetic properties of a pasteurised fibrinogen concentrate","volume":"32","author":"Kreuz","year":"2005","journal-title":"Transfusion and Apheresis Science"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2307\/2336502","article-title":"Discrete sequential boundaries for clinical trials","volume":"70","author":"Lan","year":"1983","journal-title":"Biometrika"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/01.mbc.0000169225.31173.19","article-title":"Multi-centre investigation on reference ranges for ROTEM thromboelastometry","volume":"16","author":"Lang","year":"2005","journal-title":"Blood Coagulation & Fibrinolysis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1055\/s-2007-1000370","article-title":"Clinical relevance of the effects of plasma expanders on coagulation","volume":"33","author":"Levi","year":"2007","journal-title":"Seminars in Thrombosis and Hemostasis"},{"issue":"2","key":"10.1002\/14651858.CD008864.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1213\/ANE.0b013e31822e1853","article-title":"Fibrinogen and hemostasis: a primary hemostatic target for the management of acquired bleeding","volume":"114","author":"Levy","year":"2012","journal-title":"Anesthesia and Analgesia"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1538-7836.2008.02895.x","article-title":"Simple coagulation tests improve survival prediction in patients with septic shock","volume":"6","author":"Lissalde-Lavigne","year":"2008","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0079|cit79","first-page":"202","article-title":"Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability","volume":"67","author":"Martini","year":"2009","journal-title":"The Journal of Trauma"},{"issue":"10","key":"10.1002\/14651858.CD008864.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1161\/01.ATV.0000031340.68494.34","article-title":"Platelets and thrombin generation","volume":"22","author":"Monroe","year":"2002","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1749-6632.2001.tb03491.x","article-title":"The structure and biological features of fibrinogen and fibrin","volume":"936","author":"Mosesson","year":"2001","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1399-6576.2005.00602.x","article-title":"Effects of coagulation factor deficiency on plasma coagulation kinetics determined via thrombelastography: critical roles of fibrinogen and factors II, VII, X and XII","volume":"49","author":"Nielsen","year":"2005","journal-title":"Acta Anaesthesiologica Scandinavica"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1399-6576.2005.00733.x","article-title":"Colloids decrease clot propagation and strength: role of factor XIII-fibrin polymer and thrombin-fibrinogen interactions","volume":"49","author":"Nielsen","year":"2005","journal-title":"\u00a0Acta Anaesthesiologica Scandinavica"},{"issue":"1","key":"10.1002\/14651858.CD008864.pub2-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1538-7836.2010.04083.x","article-title":"Against: fibrinogen concentrate for management of bleeding: against indiscriminate use","volume":"9","author":"Ozier","year":"2011","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0086|cit86","first-page":"183","article-title":"Relevance of plasma fibrinogen estimation in obstetric complications","volume":"38","author":"Parasnis","year":"1992","journal-title":"Jourmal of Postgraduate Medicine"},{"issue":"6","key":"10.1002\/14651858.CD008864.pub2-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0197-2456(97)00051-2","article-title":"Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis","volume":"18","author":"Pogue","year":"1997","journal-title":"Controlled Clinical Trials"},{"issue":"9095","key":"10.1002\/14651858.CD008864.pub2-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0140-6736(97)08461-4","article-title":"Overcoming the limitations of current meta-analysis of randomised controlled trials","volume":"351","author":"Pogue","year":"1998","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0089|cit89","unstructured":"Dansk Laegemiddel Information A\/S Information on drugs for professionals, fibrinogen concentrate http:\/\/pro.medicin.dk\/Medicin\/Praeparater\/6505"},{"issue":"1","key":"10.1002\/14651858.CD008864.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1538-7836.2010.04099.x","article-title":"Fibrinogen concentrate for management of bleeding","volume":"9","author":"Rahe-Meyer","year":"2011","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0091|cit91","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2008"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0092|cit92","unstructured":"CSL Behring RiSTAP\uff0dFull prescribing information http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/BloodBloodProducts\/ApprovedProducts\/LicensedProductsBLAs\/FractionatedPlasmaProducts\/ucm094006.pdf"},{"issue":"2","key":"10.1002\/14651858.CD008864.pub2-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/cc8943","article-title":"Management of bleeding following major trauma: an updated European guideline","volume":"14","author":"Rossaint","year":"2010","journal-title":"Critical Care (London, England)"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/sim.2971","article-title":"Arcsine test for publication bias in meta-analyses with binary outcomes","volume":"27","author":"Rucker","year":"2008","journal-title":"Statistics in Medicine"},{"issue":"6","key":"10.1002\/14651858.CD008864.pub2-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/j.1365-2141.2010.08208.x","article-title":"A critical evaluation of cryoprecipitate for replacement of fibrinogen","volume":"149","author":"Sorensen","year":"2010","journal-title":"British Journal of Haematology"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0096|cit96","doi-asserted-by":"crossref","unstructured":"Stanworth SJ Hunt BJ The desperate need for good-quality clinical trials to evaluate the optimal source and dose of fibrinogen in managing bleeding Critical Care (London, England) 2011 1006","DOI":"10.1186\/cc10510"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1586\/14737167.2.4.367","article-title":"Meta-analysis of rare and adverse event data","volume":"2","author":"Sutton","year":"2002","journal-title":"Expert Review in Pharmacoeconomics Outcomes Research"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0098|cit98","unstructured":"Wetterslev J Thorlund K Brok J Gluud C Trial Sequential Analysis 2010"},{"issue":"3","key":"10.1002\/14651858.CD008864.pub2-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"e59202","DOI":"10.1371\/journal.pone.0059202","article-title":"The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews","volume":"8","author":"Turner","year":"2013","journal-title":"PloS One"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"E392","DOI":"10.1532\/HSF98.20071065","article-title":"Preoperative fibrinogen levels as a predictor of postoperative bleeding after open heart surgery","volume":"10","author":"Ucar","year":"2007","journal-title":"The Heart Surgery Forum"},{"issue":"1","key":"10.1002\/14651858.CD008864.pub2-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2516.2003.00711.x","article-title":"Guidelines on the selection and use of therapeutic products to treat haemophilia and other hereditary bleeding disorders","volume":"9","author":"United Kingdom Haemophelia Centre Doctors' Organisation","year":"2003","journal-title":"Haemophilia"},{"issue":"5","key":"10.1002\/14651858.CD008864.pub2-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1399-6576.2011.02586.x","article-title":"Systematic review of the efficacy and safety of fibrinogen concentrate substitution in adults","volume":"56","author":"Warmuth","year":"2012","journal-title":"Acta Anaesthesiologica Scandinavica"},{"issue":"1","key":"10.1002\/14651858.CD008864.pub2-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jclinepi.2007.03.013","article-title":"Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis","volume":"61","author":"Wetterslev","year":"2008","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD008864.pub2-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2288-9-86","article-title":"Estimating required information size by quantifying diversity in random-effects model meta-analyses","volume":"9","author":"Wetterslev","year":"2009","journal-title":"BMC Medical Research Methodology"},{"issue":"12","key":"10.1002\/14651858.CD008864.pub2-BIB0105|cit105","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008864","article-title":"Fibrinogen concentrate in severely bleeding patients for acquired hypofibrinogenaemia","author":"Wikkels\u00f8","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD008864.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T10:02:57Z","timestamp":1672999377000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008864.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Emergency and Critical Care Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":105,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008864.pub2","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718088944.793489121","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}