{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:31:26Z","timestamp":1775284286862,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd008948","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000}}],"reference-count":38,"publisher":"Wiley","issue":"9","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008948.pub2","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T22:37:38Z","timestamp":1346798258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Irrigants for non-surgical root canal treatment in mature permanent teeth"],"prefix":"10.1002","volume":"2012","author":[{"given":"Zbys","family":"Fedorowicz","sequence":"first","affiliation":[{"name":"Head of Research College of Medicine, AMA International University of Bahrain; UKCC (Bahrain Branch); Box 25438 Awali Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Nasser","sequence":"additional","affiliation":[{"name":"University of Plymouth; Peninsula Dental School; The John Bull Building, Tamar Science Park, Plymouth UK PL6 8BU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Sequeira-Byron","sequence":"additional","affiliation":[{"name":"School of Dental Medicine; Department of Preventive, Restorative and Pediatric Dentistry; Freiburgstrasse 7 Postfach 64 Bern 10 Bern Switzerland CH-3010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael Freitas","family":"de Souza","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto Dental School, University of S\u00e3o Paulo; Department of Dental Materials and Prosthodontics; Av. Do Caf\u00e9, s\/n Ribeir\u00e3o Preto S\u00e3o Paulo (SP) Brazil 14040-050"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Carter","sequence":"additional","affiliation":[{"name":"Bangor University; North Wales Centre for Primary Care Research; Wrexham UK LL13 7YP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Heft","sequence":"additional","affiliation":[{"name":"University of Florida College of Dentistry; Department of Oral and Maxillofacial Surgery; Gainesville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,12]]},"reference":[{"issue":"4","key":"10.1002\/14651858.CD008948.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4103\/0970-9290.74225","article-title":"Comparison of 2% chlorhexidine and 5.25% sodium hypochlorite irrigating solutions on post operative pain: a randomized clinical trial","volume":"21","author":"Bashetty","year":"2010","journal-title":"Indian Journal of Dental Research"},{"issue":"4","key":"10.1002\/14651858.CD008948.pub2-BIB0002|cit2","first-page":"1159","article-title":"Antimicrobial effect of 0.2% chlorhexidine in infected root canals","volume":"33","author":"Bebek","year":"2009","journal-title":"Collegium Antropologicum"},{"issue":"2","key":"10.1002\/14651858.CD008948.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/00004770-200402000-00005","article-title":"Antibacterial activity of 2% chlorhexidine gluconate and 5.25% sodium hypochlorite in infected root canal: in vivo study","volume":"30","author":"Ercan","year":"2004","journal-title":"Journal of Endodontics"},{"issue":"1","key":"10.1002\/14651858.CD008948.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0099-2399(78)80241-6","article-title":"Analysis of clinical toxicity of endodontic irrigants","volume":"4","author":"Harrison","year":"1978","journal-title":"Journal of Endodontics"},{"issue":"11","key":"10.1002\/14651858.CD008948.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.joen.2009.08.003","article-title":"Antibacterial efficacy of MTAD final rinse and two percent chlorhexidine gel medication in teeth with apical periodontitis: a randomized double-blinded clinical trial","volume":"35","author":"Malkhassian","year":"2009","journal-title":"Journal of Endodontics"},{"issue":"5","key":"10.1002\/14651858.CD008948.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0099-2399(82)80354-3","article-title":"In vivo evaluation of chlorhexidine gluconate solution and sodium hypochlorite solution as root canal irrigants","volume":"8","author":"Ringel","year":"1982","journal-title":"Journal of Endodontics"},{"issue":"4","key":"10.1002\/14651858.CD008948.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1590\/S0103-64402006000400009","article-title":"Influence of sodium hypochlorite-based irrigants on the susceptibility of intracanal microbiota to biomechanical preparation","volume":"17","author":"Soares","year":"2006","journal-title":"Brazilian Dental Journal"},{"issue":"9","key":"10.1002\/14651858.CD008948.pub2-BIB0008|cit8","first-page":"415","article-title":"Effect of sodium hypochlorite with the addition of a proteolytic enzyme on postoperative discomfort: a multicenter randomized clinical trial","volume":"58","author":"Taschieri","year":"2009","journal-title":"Minerva Stomatologica"},{"issue":"3","key":"10.1002\/14651858.CD008948.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/01.don.0000137642.50944.a2","article-title":"Effect of MTAD on postoperative discomfort: a randomized clinical trial","volume":"31","author":"Torabinejad","year":"2005","journal-title":"Journal of Endodontics"},{"issue":"6","key":"10.1002\/14651858.CD008948.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1365-2591.2006.01121.x","article-title":"In vivo evaluation of microbial reduction after chemo-mechanical preparation of human root canals containing necrotic pulp tissue","volume":"39","author":"Vianna","year":"2006","journal-title":"International Endodontic Journal"},{"issue":"5","key":"10.1002\/14651858.CD008948.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S1079-2104(03)00168-9","article-title":"The effect of chlorhexidine as an endodontic disinfectant","volume":"96","author":"Zamany","year":"2003","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics"},{"issue":"2","key":"10.1002\/14651858.CD008948.pub2-BIB0012|cit12","first-page":"198","article-title":"Root canal irrigation [Turkish]","volume":"2","author":"Bayirli","year":"1968","journal-title":"Istanbul Universitesi Dishekimligi Fakultesi Dergisi"},{"issue":"2","key":"10.1002\/14651858.CD008948.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/sj.bdj.4813819","article-title":"An alternative regimen for root canal disinfection","volume":"201","author":"Bonsor","year":"2006","journal-title":"British Dental Journal"},{"issue":"8","key":"10.1002\/14651858.CD008948.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.joen.2010.04.012","article-title":"Postoperative pain after the application of two different irrigation devices in a prospective randomized clinical trial","volume":"36","author":"Gondim","year":"2010","journal-title":"Journal of Endodontics"},{"issue":"8","key":"10.1002\/14651858.CD008948.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.joen.2010.04.024","article-title":"Influence of a passive sonic irrigation system on the elimination of bacteria from root canal systems: a clinical study","volume":"36","author":"Huffaker","year":"2010","journal-title":"Journal of Endodontics"},{"issue":"2","key":"10.1002\/14651858.CD008948.pub2-BIB0016|cit16","first-page":"111","article-title":"Different pharmacological solutions in intracanal irrigation","volume":"13","author":"Paudel","year":"2011","journal-title":"Nepal Medical College Journal"},{"issue":"5","key":"10.1002\/14651858.CD008948.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1399-302X.2008.00440.x","article-title":"Molecular identification and quantification of bacteria from endodontic infections using real-time polymerase chain reaction","volume":"23","author":"Blome","year":"2008","journal-title":"Oral Microbiology and Immunology"},{"key":"10.1002\/14651858.CD008948.pub2-BIB0018|cit18","first-page":"111","article-title":"New classification of physical status","volume":"24","author":"American Society of Anesthesiologists","year":"1963","journal-title":"Anesthesiology"},{"issue":"7572","key":"10.1002\/14651858.CD008948.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/bmj.38987.492014.94","article-title":"How to formulate research questions","volume":"333","author":"Brown","year":"2006","journal-title":"BMJ"},{"issue":"3","key":"10.1002\/14651858.CD008948.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0030-4220(83)90333-X","article-title":"Bacteriologic evaluation of the effect of 0.5 percent sodium hypochlorite in endodontic therapy","volume":"55","author":"Bystr\u00f6m","year":"1983","journal-title":"Oral Surgery, Oral Medicine, and Oral Pathology"},{"issue":"1","key":"10.1002\/14651858.CD008948.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.joen.2011.08.013","article-title":"Irrigation trends among American Association of Endodontists Members: A web-based survey","volume":"38","author":"Dutner","year":"2011","journal-title":"Journal of Endodontics"},{"issue":"7109","key":"10.1002\/14651858.CD008948.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD008948.pub2-BIB0023|cit23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004969.pub2","article-title":"Antibiotic use for irreversible pulpitis","author":"Fedorowicz","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD008948.pub2-BIB0024|cit24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005296.pub2","article-title":"Single versus multiple visits for endodontic treatment of permanent teeth","author":"Figini","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD008948.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2591.2005.00950.x","article-title":"Periapical resurgery versus periapical surgery: a 5-year longitudinal comparison","volume":"38","author":"Gagliani","year":"2005","journal-title":"International Endodontic Journal"},{"issue":"3","key":"10.1002\/14651858.CD008948.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/01.don.0000137651.01496.48","article-title":"In vivo debridement efficacy of ultrasonic irrigation following hand-rotary instrumentation in human mandibular molars","volume":"31","author":"Gutarts","year":"2005","journal-title":"Journal of Endodontics"},{"issue":"5","key":"10.1002\/14651858.CD008948.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0030-4220(90)90396-A","article-title":"A study of the comparative efficacy of four common analgesics in the control of post-surgical dental pain","volume":"70","author":"Habib","year":"1990","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics"},{"key":"10.1002\/14651858.CD008948.pub2-BIB0028|cit28","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD008948.pub2-BIB0029|cit29","first-page":"253","article-title":"Problems in Disinfection of the Root Canal System","volume-title":"Problems in Endodontics: Etiology, Diagnosis and Treatment. Edited by M H\u00fclsmann and E Sh\u00e4fer","author":"H\u00fclsmann","year":"2009"},{"issue":"6","key":"10.1002\/14651858.CD008948.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1875-595X.2008.tb00354.x","article-title":"Sodium hypochlorite in endodontics: an update review","volume":"58","author":"Mohammadi","year":"2008","journal-title":"International Dental Journal"},{"issue":"4","key":"10.1002\/14651858.CD008948.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1365-2591.2008.01540.x","article-title":"The properties and applications of chlorhexidine in endodontics","volume":"42","author":"Mohammadi","year":"2009","journal-title":"International Endodontic Journal"},{"issue":"6","key":"10.1002\/14651858.CD008948.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/154411130401500604","article-title":"Pathogenesis of apical periodontitis and the causes of endodontic failures","volume":"15","author":"Nair","year":"2004","journal-title":"Critical Reviews in Oral Biology and Medicine"},{"issue":"10","key":"10.1002\/14651858.CD008948.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0099-2399(76)80047-7","article-title":"Pain in endodontic therapy: preliminary study","volume":"2","author":"O'Keefe","year":"1976","journal-title":"Journal of Endodontics"},{"key":"10.1002\/14651858.CD008948.pub2-BIB0034|cit34","article-title":"Apical Periodontitis: Microbial Infection and Host Responses","volume-title":"Essential Endodontology: Prevention and Treatment of Apical Periodontitis","author":"\u00d8rstavik","year":"2007"},{"key":"10.1002\/14651858.CD008948.pub2-BIB0035|cit35","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2011"},{"issue":"5","key":"10.1002\/14651858.CD008948.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"issue":"3","key":"10.1002\/14651858.CD008948.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1016\/j.tripleo.2011.02.015","article-title":"MTAD in endodontics: an update review","volume":"112","author":"Singla","year":"2011","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics"},{"issue":"5","key":"10.1002\/14651858.CD008948.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.joen.2005.09.014","article-title":"Root canal irrigants","volume":"32","author":"Zehnder","year":"2006","journal-title":"Journal of Endodontics"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD008948.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T08:32:22Z","timestamp":1733992342000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008948.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Oral Health Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,9,12]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,9]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008948.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,12]]}}}