{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:42:16Z","timestamp":1790505736497,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd008950","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T00:00:00Z","timestamp":1341964800000}}],"reference-count":56,"publisher":"Wiley","issue":"7","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd008950.pub2","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T19:42:12Z","timestamp":1341603732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Low oxygen concentrations for embryo culture in assisted reproductive technologies"],"prefix":"10.1002","volume":"2012","author":[{"given":"Stephan","family":"Bontekoe","sequence":"first","affiliation":[{"name":"Academic Medical Centre, University of Amsterdam; Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology; Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Mantikou","sequence":"additional","affiliation":[{"name":"Academic Medical Centre, University of Amsterdam; Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology; Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelon","family":"van Wely","sequence":"additional","affiliation":[{"name":"Academic Medical Centre, University of Amsterdam; Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology; Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srividya","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Guys and St Thomas Hospital; Lambeth Palace Rd London UK SE17EH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd","family":"Repping","sequence":"additional","affiliation":[{"name":"Academic Medical Centre, University of Amsterdam; Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology; Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Mastenbroek","sequence":"additional","affiliation":[{"name":"Academic Medical Center, University of Amsterdam; Center for Reproductive Medicine; Meibergdreef 9 (Q3-119) Amsterdam Netherlands 1105 AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,11]]},"reference":[{"key":"10.1002\/14651858.CD008950.pub2-BIB0001|cit1","article-title":"The effect of reduced oxygen concentration on ICSI outcomes in two different culture media systems","author":"Iacobelli","year":"2008","journal-title":"Abstracts of the 24th annual meeting of the ESHRE"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fertnstert.2009.03.077","article-title":"A prospective, randomized trial on the effect of atmospheric versus reduced oxygen concentration on the outcome of intracytoplasmic sperm injection cycles","volume":"94","author":"Kovacic","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/humrep\/den368","article-title":"A controlled randomized trial evaluating the effect of the lowered incubator oxygen tension on live births in a predominantly blastocyst transfer program","volume":"24","author":"Meintjes","year":"2009","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0004|cit4","article-title":"Effect of oxygen concentration on the culture of human embryos: a prospective, randomized study","author":"Minasi","year":"2003","journal-title":"Abstracts of the 19th annual meeting of the ESHRE"},{"issue":"3","key":"10.1002\/14651858.CD008950.pub2-BIB0005|cit5","first-page":"32","article-title":"Effect of oxygen conditions on the results of an oocyte donation program: A prospective randomized trial","volume":"15","author":"Sepulveda","year":"May-June 2011","journal-title":"Jornal Brasileiro de Reproducao Assistida"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.fertnstert.2005.07.215","article-title":"Choosing the optimal incubator environment for day 3 culture: triple gas vs. 5% CO2 in air, a prospective, randomized trial","volume":"84 Suppl 1","author":"Silverberg","year":"2005","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.fertnstert.2008.03.051","article-title":"Low-oxygen compared with high-oxygen atmosphere in blastocyst culture, a prospective randomized study","volume":"91","author":"Waldenstr\u00f6m","year":"2009","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1002\/14651858.CD008950.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S1472-6483(10)61136-4","article-title":"Effect of oxygen concentration during the incubation of embryos of women undergoing ICSI and embryo transfer: A prospective randomized study","volume":"11","author":"Bahceci","year":"2005 Oct","journal-title":"Reproductive Biomedicine Online"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.fertnstert.2008.07.1212","article-title":"Comparison of atmospheric oxygen versus low oxygen on human sibling embryo development","volume":"90 Suppl 1","author":"Cieslak Janzen","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0010|cit10","first-page":"i160","article-title":"Reduced O2 concentration in first 3 days of culture yields more blastocysts with better quality: A prospective randomized study on sibling oocytes","volume":"23 Suppl 1","author":"Ciray","year":"2008","journal-title":"Human Reproduction"},{"issue":"4","key":"10.1002\/14651858.CD008950.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.fertnstert.2008.07.1707","article-title":"In vitro culture under physiologic oxygen concentration improves blastocyst yield and quality: a prospective randomized survey on sibling oocytes","volume":"91 Suppl","author":"Ciray","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0012|cit12","article-title":"The effect of culture under low oxygen tension on developmental competence of post-thawed human embryos","author":"Curnelle","year":"2010","journal-title":"Abstracts of the annual meeting of the ESHRE"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.fertnstert.2006.07.641","article-title":"The use of low oxygen culture conditions yields similar pregnancy rates with day 2 vs day 3 embryo transfer","volume":"86 Suppl 2","author":"Dasig","year":"2006","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD008950.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0015-0282(16)57305-1","article-title":"Effect of oxygen concentration on in vitro fertilization and embryo culture in the human and the mouse","volume":"63","author":"Dumoulin","year":"1995","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1002\/14651858.CD008950.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/humrep\/14.2.465","article-title":"Effect of oxygen concentration on human in-vitro fertilization and embryo culture","volume":"14","author":"Dumoulin","year":"1999","journal-title":"Human Reproduction"},{"issue":"1","key":"10.1002\/14651858.CD008950.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10815-006-9088-3","article-title":"Effect of micro-environment maintenance on embryo culture after in-vitro fertilization: Comparison of top-load mini incubator and conventional front-load incubator","volume":"24","author":"Fujiwara","year":"2007","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0017|cit17","article-title":"Culture embryos under low oxygen conditions improves clinical results","author":"Gamiz Izquierdo","year":"2010","journal-title":"Abstract of the annual meeting of the ESHRE"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0018|cit18","first-page":"i59","article-title":"Improved preimplantation development and higher pregnancy rates associated with 6% versus ambient oxygen concentration during in vitro embryo culture","volume":"25 Suppl 1","author":"Graham","year":"2010","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.fertnstert.2008.07.1220","article-title":"Effects on low oxygen culture on embryo development and IVF outcome","volume":"90 Suppl 1","author":"Gvakharia","year":"2008","journal-title":"Fertility and Sterility"},{"issue":"3","key":"10.1002\/14651858.CD008950.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.fertnstert.2007.03.040","article-title":"Incubator management in an assisted reproductive technology laboratory","volume":"89","author":"Higdon","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.fertnstert.2008.07.1547","article-title":"Reduced oxygen tension helps increase the quality of blastocyst available on D5","volume":"90 Suppl 1","author":"Hoff","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0022|cit22","unstructured":"Kasterstein E Strassburger D Komarovsky D Bern O Komsky A Maslansky B Improved embryo development after incubation in reduced oxygen concentration Abstracts of the 24th annual meeting of the ESHRE 2008"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2005.01.043","article-title":"Effects of reduced oxygen concentrations on IVF outcome","volume":"83 Suppl 2","author":"Kea","year":"2005","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD008950.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.fertnstert.2006.05.066","article-title":"Effect of reduced oxygen concentrations on the outcome of in vitro fertilization","volume":"87","author":"Kea","year":"2007","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.fertnstert.2008.02.041","article-title":"Improving embryo culture conditions by reducing oxygen tension may help increase the implantation potential of an embryo in the donor recipient population","volume":"89 Suppl 2","author":"Khabani","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fertnstert.2005.07.038","article-title":"The comparison of embryo developments and pregnancy rates in human in vitro culture conditions at different oxygen gas phase","volume":"84 Suppl 1","author":"Kim","year":"2005","journal-title":"Fertility and Sterility"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD008950.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"S319","DOI":"10.1016\/j.fertnstert.2007.07.1070","article-title":"Effect of oxygen concentrations on IVM, IVF and embryo development of immature oocytes from stimulated cycles of human IVF-ET program","volume":"88","author":"Kim","year":"2007","journal-title":"Fertility & Sterility"},{"issue":"2","key":"10.1002\/14651858.CD008950.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1472-6483(10)60199-X","article-title":"Influence of atmospheric versus reduced oxygen concentration on development of human blastocysts in vitro: a prospective study on sibling oocytes","volume":"17","author":"Kovacic","year":"2008","journal-title":"Reproductive Biomedicine Online"},{"issue":"3","key":"10.1002\/14651858.CD008950.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fertnstert.2009.07.1561","article-title":"The effect of oxygen concentration on human embryo culture: A prospective randomized controlled trial","volume":"92 Suppl","author":"Loutradi","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0030|cit30","doi-asserted-by":"crossref","unstructured":"Madaschi C Guilherme P Izzo CPM Yamakami LY Fassolas G Izzo CR Evaluation the effect of lowered incubator oxygen tension on embryo quality Fertility and Sterility Annual Meeting of the American Society for Reproductive Medicine, ASRM 2010","DOI":"10.1016\/j.fertnstert.2010.07.956"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0031|cit31","first-page":"9","article-title":"Prospective randomized study to compare the effects of embryo culture performed in an incubator Class 100 with High Efficiency Particulate Air filter (HEPA) plus Volatile Organic Compounds (VOC) filter on outcome measures of ICSI cycles","volume":"13 (2), 2009","author":"Mancebo","year":"April-June 2009","journal-title":"Jornal Brasileiro de Reproducao Assistida"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0032|cit32","first-page":"111","article-title":"Comparison between ambient (20%) or reduced (5%) oxygen concentration for human in-vitro fertilization using a system of culture medium droplets under oil","volume":"13","author":"Meijers","year":"1998","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD008950.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0015-0282(00)01481-3","article-title":"The effect of lowered incubator oxygen tension on implantation, pregnancy and cryopreservation rates in a predominantly Day-5 embryo transfer program","volume":"74 Suppl 1","author":"Meintjes","year":"2000","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0034|cit34","first-page":"i2","article-title":"Low oxygen embryo culture is associated with improved day 3 embryo quality: A prospective randomized controlled trial","volume":"26","author":"Mitsoli","year":"2011","journal-title":"Human Reproduction. Conference: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, ESHRE 2011 Stockholm Sweden"},{"issue":"2","key":"10.1002\/14651858.CD008950.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.fertnstert.2009.02.048","article-title":"Comparison of 5% and ambient oxygen during days 3\u20135 of in vitro culture of human embryos","volume":"93","author":"Nanassy","year":"2010","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0036|cit36","first-page":"i199","article-title":"IVF\/ICSI outcomes after human embryo development on low oxygen tension: A meta-analysis","volume":"26","author":"Oliveira","year":"2011","journal-title":"Human Reproduction. Conference: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, ESHRE 2011 Stockholm Sweden"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0037|cit37","article-title":"Effect of low oxygen tension on human IVM\/F-ET program","author":"Park","year":"2001","journal-title":"http:\/\/www.liyabiotech.com\/upfiles\/house\/1134436097.pdf"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/j.0001-6349.2005.00630.x","article-title":"The impact of oxygen tension on developmental competence of post-thaw human embryos","volume":"84","author":"Petersen","year":"2005","journal-title":"Acta Obstetrica Gynecologica Scandinavica"},{"issue":"Suppl","key":"10.1002\/14651858.CD008950.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"S351","DOI":"10.1016\/j.fertnstert.2008.07.1550","article-title":"Is triple gas culture effective? Practical?","volume":"90","author":"Portmann","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0040|cit40","first-page":"25 (pp i190)","article-title":"Improved human embryo quality in days 3 and 5 with a low oxygen closed culture system","author":"Prados","year":"June 2010","journal-title":"Human Reproduction. Conference: 26th Annual Meeting of the European Society of Human Reproduction and Embryology, ESHRE Rome Italy."},{"key":"10.1002\/14651858.CD008950.pub2-BIB0041|cit41","article-title":"Lower oxygen concentration is beneficial for the early human embryo development","author":"Reeka","year":"2004","journal-title":"Abstracts of the 20th annual meeting of the ESHRE"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0042|cit42","article-title":"Effect of low-oxygen compared with high-oxygen atmosphere on the outcomes of in vitro fertilization, a prospective randomized study","author":"Ryu","year":"2010","journal-title":"Abstracts of the annual meeting of the ESHRE"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0043|cit43","article-title":"Reduced oxygen during embryo culture increase fertilisation and subsequent pregnancy rates in IVF","author":"Sjoblom","year":"2008","journal-title":"Abstracts of the 24th annual meeting of the ESHRE"},{"issue":"143","key":"10.1002\/14651858.CD008950.pub2-BIB0044|cit44","article-title":"IVF\/ICSI outcomes after culture of human embryos at low oxygen tension: a meta-analysis","volume":"9","author":"Sobrinho","year":"2011","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0045|cit45","unstructured":"Tejera A Gmiz P Romero JL De Los Santos JM Grau N De Los Santos MJ Culture under low oxygen tension improves embryo quality in egg donation cycles Molecular Human Reproduction"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/humrep\/15.suppl_2.199","article-title":"Toxic effects of oxygen on human embryo development","volume":"15 Suppl 2","author":"Catt","year":"2000","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD008950.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/humrep\/dep456","article-title":"Effect of in vitro culture of human embryos on birthweight of newborns","volume":"25","author":"Dumoulin","year":"2010","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1113\/jphysiol.2005.102681","article-title":"Effect of culturing mouse embryos under different oxygen concentrations on subsequent fetal and placental development","volume":"572","author":"Feil","year":"2006","journal-title":"Journal of Physiology"},{"issue":"2","key":"10.1002\/14651858.CD008950.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1530\/jrf.0.0990673","article-title":"Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits","volume":"99","author":"Fischer","year":"1993","journal-title":"Journal of Reproduction and Fertility"},{"issue":"1-2","key":"10.1002\/14651858.CD008950.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.anireprosci.2006.10.008","article-title":"The role of oxygen in ruminant preimplantation embryo development and metabolism","volume":"98","author":"Harvey","year":"2007","journal-title":"Animal Reproduction Science"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0051|cit51","article-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]","author":"Higgins","year":"2011. Available from www.cochrane-handbook.org","journal-title":"The Cochrane Collaboration"},{"issue":"4","key":"10.1002\/14651858.CD008950.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1472-6483(10)61276-X","article-title":"Impact of oxygen concentration on embryonic development of mouse zygotes","volume":"9","author":"Karagenc","year":"2004","journal-title":"Reproductive Biomedicine Online"},{"key":"10.1002\/14651858.CD008950.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10059-011-0016-8","article-title":"Biochemical and morphological effects of hypoxic environment on human embryonic stem cells in long-term culture and differentiating embryoid bodies","volume":"31","author":"Lim","year":"2011","journal-title":"Molecules and Cells"},{"issue":"8","key":"10.1002\/14651858.CD008950.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1093\/humrep\/deh879","article-title":"Comment 1 on. Design and analysis of a randomized controlled trial studying preimplantation genetic screening","volume":"20","author":"Mastenbroek","year":"August 2005","journal-title":"Human Reproduction"},{"issue":"5","key":"10.1002\/14651858.CD008950.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/humrep\/deg133","article-title":"Common statistical errors in the design and analysis of subfertility trials","volume":"18","author":"Vail","year":"2003","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD008950.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0015-0282(16)41722-X","article-title":"The temperature, pH, and partial pressure of oxygen in the cervix and uterus of women and uterus of rats during the cycle","volume":"27","author":"Yedwab","year":"1976","journal-title":"Fertility and Sterility"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD008950.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T09:02:18Z","timestamp":1735549338000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD008950.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Gynaecology and Fertility Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,11]]},"references-count":56,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd008950.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,11]]}}}