{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:13:04Z","timestamp":1790244784463,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd009096","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000}}],"reference-count":40,"publisher":"Wiley","issue":"8","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd009096.pub2","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T23:35:53Z","timestamp":1408750553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension"],"prefix":"10.1002","volume":"2014","author":[{"given":"Edmond CK","family":"Li","sequence":"first","affiliation":[{"name":"University of Saskatchewan; Anesthesiology, Perioperative Medicine and Pain Management; Royal University Hospital 103 Hospital Dr. Saskatoon SK Canada S7N 0W8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balraj S","family":"Heran","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Sciences Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Wright","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Sciences Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,22]]},"reference":[{"issue":"8","key":"10.1002\/14651858.CD009096.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3109\/10641969709083217","article-title":"Valsartan: long-term efficacy and tolerability compared to lisinopril in elderly patients with essential hypertension","volume":"19","author":"Bremner","year":"1997","journal-title":"Clinical & Experimental Hypertension"},{"issue":"19","key":"10.1002\/14651858.CD009096.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1056\/NEJMoa042274","article-title":"Angiotensin-receptor blockade versus converting-enzyme inhibition in Type 2 diabetes and nephropathy","volume":"351","author":"Barnett","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"9","key":"10.1002\/14651858.CD009096.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/ajh.2008.217","article-title":"Effect of valsartan and ramipril on atrial fibrillation recurrence and P-wave dispersion in hypertensive patients with recurrent symptomatic lone atrial fibrillation","volume":"21","author":"Fogari","year":"2008","journal-title":"American Journal of Hypertension"},{"issue":"1","key":"10.1002\/14651858.CD009096.pub2-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1177\/1074248410395018","article-title":"Effect of telmisartan and ramipril on atrial fibrillation recurrence and severity in hypertensive patients with metabolic syndrome and recurrent symptomatic paroxysmal and persistent atrial fibrillation","volume":"17","author":"Fogari","year":"2011","journal-title":"Journal of Cardiovascular Pharmacology and Therapeutics"},{"issue":"8","key":"10.1002\/14651858.CD009096.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1517\/14656566.2012.683175","article-title":"Effects of valsartan or ramipril addition to amlodipine\/hydrochlorothiazide combination on left ventricular mass in diabetic hypertensive patients with left ventricular hypertrophy","volume":"13","author":"Fogari","year":"2012","journal-title":"Expert Opinion on Pharmacotherapy"},{"issue":"2","key":"10.1002\/14651858.CD009096.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1046\/j.1523-1755.2000.00224.x","article-title":"Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy","volume":"58","author":"Lacourciere","year":"2000","journal-title":"Kidney International"},{"issue":"1","key":"10.1002\/14651858.CD009096.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ahj.2004.03.020","article-title":"Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial\/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET\/TRANSCEND) trials","volume":"148","author":"Teo","year":"2004","journal-title":"American Heart Journal"},{"key":"10.1002\/14651858.CD009096.pub2-BIB0008|cit8","doi-asserted-by":"crossref","unstructured":"Yusuf S Teo KK Pogue J Dyal L Copland I Schurnacher H Telmisartan, ramipril, or both in patients at high risk for vascular events New England Journal of Medicine 2008 1547 59","DOI":"10.1056\/NEJMoa0801317"},{"issue":"4","key":"10.1002\/14651858.CD009096.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/147323000903700403","article-title":"Drugs with blocking effects on the renin-angiotensin-aldosterone system do not improve endothelial dysfunction long-term in hypertensive patients","volume":"37","author":"Sozen","year":"2009","journal-title":"Journal of International Medical Research"},{"issue":"8","key":"10.1002\/14651858.CD009096.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/sj.jhh.1002025","article-title":"Aggressive antihypertensive strategies based on hydrochlorothiazide, candesartan or lisinopril decrease left ventricular mass and improve arterial compliance in patients with type II diabetes mellitus and hypertension","volume":"20","author":"Spoelstra-de Man","year":"2006","journal-title":"Journal of Human Hypertension"},{"issue":"4","key":"10.1002\/14651858.CD009096.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0735-1097(02)02033-8","article-title":"Augmentation of myocardial blood flow in hypertensive heart disease by angiotensin antagonists: a comparison of lisinopril and losartan","volume":"40","author":"Akinboboye","year":"2002","journal-title":"Journal of the American College of Cardiology"},{"issue":"5","key":"10.1002\/14651858.CD009096.pub2-BIB0012|cit12","first-page":"481","article-title":"CORD: COmparsion of Recommended Doses of ACE inhibitors and angiotensin II receptor blockers","volume":"55","author":"Spinar","year":"2009","journal-title":"Vnitrni Lekarstvi"},{"issue":"1","key":"10.1002\/14651858.CD009096.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/hr.2010.205","article-title":"Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients","volume":"34","author":"Derosa","year":"2011","journal-title":"Hypertension Research - Clinical & Experimental"},{"issue":"1","key":"10.1002\/14651858.CD009096.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdiacomp.2005.05.002","article-title":"Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy","volume":"20","author":"Didangelos","year":"2006","journal-title":"Journal of Diabetes & its Complications"},{"issue":"5","key":"10.1002\/14651858.CD009096.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000072820","article-title":"Effect of angiotensin II receptor blocker on plasma levels of TGF-beta 1 and interstitial fibrosis in hypertensive kidney transplant patients","volume":"23","author":"el-Agroudy","year":"2003","journal-title":"American Journal of Nephrology"},{"issue":"9215","key":"10.1002\/14651858.CD009096.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(00)02213-3","article-title":"Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial - the Losartan Heart Failure Survival Study ELITE II","volume":"355","author":"Pitt","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD009096.pub2-BIB0017|cit17","first-page":"S61","article-title":"Antihypertensive effects of candesartan cilexetil, enalapril and placebo","volume":"11 Suppl 2","author":"Franke","year":"1997","journal-title":"Journal of Human Hypertension"},{"issue":"8","key":"10.1002\/14651858.CD009096.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s12325-008-0083-1","article-title":"Comparison of the effects of quinapril and irbesartan on P-wave dispersion in hypertensive patients","volume":"25","author":"Guntekin","year":"2008","journal-title":"Advances in Therapy"},{"issue":"6","key":"10.1002\/14651858.CD009096.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1681\/ASN.2006121372","article-title":"Renoprotection of Optimal Antiproteinuric Doses (ROAD) study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency","volume":"18","author":"Hou","year":"2007","journal-title":"Journal of the American Society of Nephrology"},{"issue":"5","key":"10.1002\/14651858.CD009096.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1053\/j.ajkd.2005.02.022","article-title":"Low doses of losartan and trandolapril improve arterial stiffness in hemodialysis patients","volume":"45","author":"Ichihara","year":"2005","journal-title":"American Journal of Kidney Diseases"},{"issue":"9","key":"10.1002\/14651858.CD009096.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1365-2362.2010.02319.x","article-title":"Effects of telmisartan and enalapril on renoprotection in patients with mild to moderate chronic kidney disease","volume":"40","author":"Nakamura","year":"2010","journal-title":"European Journal of Clinical Investigation"},{"issue":"9352","key":"10.1002\/14651858.CD009096.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(03)12229-5","article-title":"Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial","volume":"361","author":"Nakao","year":"2003","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD009096.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00045391-199905000-00007","article-title":"Comparison of telmisartan with lisinopril in patients with mild-to-moderate hypertension","volume":"6","author":"Neutel","year":"1999","journal-title":"American Journal of Therapeutics"},{"issue":"9335","key":"10.1002\/14651858.CD009096.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(02)09895-1","article-title":"Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial","volume":"360","author":"Dickstein","year":"2002","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD009096.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/01.HYP.0000153308.91043.97","article-title":"Effect of treatment with candesartan or enalapril on subcutaneous small artery structure in hypertensive patients with non insulin-dependent diabetes mellitus","volume":"45","author":"Rizzoni","year":"2005","journal-title":"Hypertension"},{"issue":"6","key":"10.1002\/14651858.CD009096.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.jhh.1001812","article-title":"Aggressive antihypertensive therapy based on hydrochlorothiazide, candesartan or lisinopril as initial choice in hypertensive type II diabetic individuals: effects on albumin excretion, endothelial function and inflammation in a double-blind, randomized clinical trial","volume":"19","author":"Schram","year":"2005","journal-title":"Journal of Human Hypertension"},{"issue":"2","key":"10.1002\/14651858.CD009096.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.diabres.2005.06.010","article-title":"Beneficial effect of lisinopril plus telmisartan in patients with type 2 diabetes, microalbuminuria and hypertension","volume":"71","author":"Sengul","year":"2006","journal-title":"Diabetes Research & Clinical Practice"},{"issue":"4","key":"10.1002\/14651858.CD009096.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2169\/internalmedicine.45.1515","article-title":"A five-year comparison of the renal protective effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with non-diabetic nephropathy","volume":"45","author":"Shoda","year":"2006","journal-title":"Internal Medicine"},{"key":"10.1002\/14651858.CD009096.pub2-BIB0029|cit29","doi-asserted-by":"crossref","unstructured":"Suzuki H Kanno Y Kaneko K Kaneko M Kotaki S Mimura T Comparison of the effects of angiotensin receptor antagonist, angiotensin converting enzyme inhibitor, and their combination on regression of left ventricular hypertrophy of diabetes type 2 patients on recent onset hemodialysis therapy Therapeutic Apheresis and Dialysis 2004 320 7","DOI":"10.1111\/j.1526-0968.2004.00142.x"},{"issue":"4","key":"10.1002\/14651858.CD009096.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s592-001-8073-2","article-title":"Efficacy of ACE inhibitors and ATII receptor blockers in patients with microalbuminuria: a prospective study","volume":"38","author":"Tutuncu","year":"2001","journal-title":"Acta Diabetologica"},{"issue":"8","key":"10.1002\/14651858.CD009096.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3109\/0886022X.2010.502277","article-title":"A comparison of the effects of ramipril and losartan on blood pressure control and left ventricle hypertrophy in patients with autosomal dominant polycystic kidney disease","volume":"32","author":"Ulusoy","year":"2010","journal-title":"Renal Failure"},{"issue":"20","key":"10.1002\/14651858.CD009096.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1056\/NEJMoa032292","article-title":"Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both","volume":"349","author":"Pfeffer","year":"2003","journal-title":"New England Journal of Medicine"},{"issue":"6","key":"10.1002\/14651858.CD009096.pub2-BIB0033|cit33","first-page":"999","article-title":"A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice","volume":"3","author":"Veronesi","year":"2007","journal-title":"Vascular Health & Risk Management"},{"issue":"5","key":"10.1002\/14651858.CD009096.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/hrt.2007.117978","article-title":"The Hong Kong diastolic heart failure study: a randomised controlled trial of diuretics, irbesartan and ramipril on quality of life, exercise capacity, left ventricular global and regional function in heart failure with a normal ejection fraction","volume":"94","author":"Yip","year":"2008","journal-title":"Heart"},{"key":"10.1002\/14651858.CD009096.pub2-BIB0035|cit35","unstructured":"Deeks JJ Higgins JPT Altman DG Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org Available from www.cochrane-handbook.org"},{"issue":"4","key":"10.1002\/14651858.CD009096.pub2-BIB0036|cit36","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003823.pub2","article-title":"Blood pressure lowering efficacy of angiotensin converting enzyme (ACE) inhibitors for primary hypertension","author":"Heran","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD009096.pub2-BIB0037|cit37","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003822.pub2","article-title":"Blood pressure lowering efficacy of angiotensin receptor blockers for primary hypertension","author":"Heran","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD009096.pub2-BIB0038|cit38","unstructured":"Higgins JPT Altman DG Sterne JAC Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"12","key":"10.1002\/14651858.CD009096.pub2-BIB0039|cit39","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000028.pub2","article-title":"Pharmacotherapy for hypertension in the elderly","author":"Musini","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD009096.pub2-BIB0040|cit40","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001841.pub2","article-title":"First-line drugs for hypertension","author":"Wright","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD009096.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:50:47Z","timestamp":1697449847000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD009096.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Hypertension Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,22]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd009096.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,22]]}}}