{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:36:02Z","timestamp":1791466562992,"version":"4.3.4"},"update-to":[{"DOI":"10.1002\/14651858.cd009178.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000}}],"reference-count":110,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd009178.pub4","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T17:42:50Z","timestamp":1605375770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Pharmacotherapies for sleep disturbances in dementia"],"prefix":"10.1002","volume":"2020","author":[{"given":"Jenny","family":"McCleery","sequence":"additional","affiliation":[{"name":"Oxford Health NHS Foundation Trust; Banbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann L","family":"Sharpley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; Oxford University; Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"issue":"12","key":"10.1002\/14651858.CD009178.pub4-BIB0001|cit1","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.jagp.2013.12.174","article-title":"Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind and placebo-controlled study","volume":"22","author":"Camargos","year":"2014","journal-title":"American Journal of Geriatric Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD009178.pub4-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/JCP.0000000000000237","article-title":"Trazodone and cognitive performance in Alzheimer disease","volume":"35","author":"Camargos","year":"2015","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"2","key":"10.1002\/14651858.CD009178.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1532-5415.2007.01543.x","article-title":"Melatonin and bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease","volume":"56","author":"Dowling","year":"2008","journal-title":"American Journal of Geriatric Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD009178.pub4-BIB0004|cit4","first-page":"S195","article-title":"Clinical polysomnography trial of suvorexant for treating insomnia in Alzheimer's disease: trial design and baseline characteristics of participants","volume":"5","author":"Herring","year":"2018","journal-title":"Journal of Prevention of Alzheimer's Disease"},{"issue":"3","key":"10.1002\/14651858.CD009178.pub4-BIB0005|cit5","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/alz.12035","article-title":"Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial","volume":"16","author":"Herring","year":"2020","journal-title":"Alzheimer's & Dementia"},{"issue":"4","key":"10.1002\/14651858.CD009178.pub4-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s41999-018-0068-9","article-title":"A randomized placebo-controlled trial evaluating the effect of melatonin on sleep quality in patients with mild-moderate dementia","volume":"9","author":"Morales-Delgado","year":"2018","journal-title":"European Geriatric Medicine"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0007|cit7","unstructured":"A double-blind, randomized, placebo-controlled study of the efficacy, safety and tolerability of 8 week treatment of Rozerem 8 mg (QHS) in sleep disturbed, mild to moderately severe Alzheimer's disease subjects clinicaltrials.gov\/ct2\/show\/NCT00325728"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0008|cit8","unstructured":"Clinical Trial Synopsis 01-05-TL-375-061, NCT#00325728: A double-blind, randomized, placebo-controlled study of the efficacy, safety and tolerability of 8 week treatment of Rozerem 8 mg (QHS) in sleep disturbed, mild to moderately severe Alzheimer's disease subjects www.takeda.com\/research\/ct\/pdf\/report\/15_Ramelteon_01-05-TL-375-061_ClinicalTrialSynopsis_NCT00325728_en.pdf"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0009|cit9","unstructured":"Study of lemborexant for irregular sleep-wake rhythm disorder in mild to moderate Alzheimer's disease dementia clinicaltrials.gov\/ct2\/show\/NCT03001557"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jalz.2019.06.4392","article-title":"Response to treatment with lemborexant: subjects with irregular sleep-wake rhythm disorder and Alzheimer's disease dementia","volume":"15 (7 Suppl)","author":"Thein","year":"2019","journal-title":"Alzheimer's & Dementia"},{"issue":"12","key":"10.1002\/14651858.CD009178.pub4-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/gps.760","article-title":"Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia","volume":"17","author":"Serfaty","year":"2002","journal-title":"International Journal of Geriatric Psychiatry"},{"issue":"7","key":"10.1002\/14651858.CD009178.pub4-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/sleep\/26.7.893","article-title":"A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease","volume":"26","author":"Singer","year":"2003","journal-title":"Sleep"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0013|cit13","first-page":"947","article-title":"Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial","volume":"9","author":"Wade","year":"2014","journal-title":"Clinical Interventions in Aging"},{"issue":"4","key":"10.1002\/14651858.CD009178.pub4-BIB0014|cit14","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1097\/JCP.0b013e3182946702","article-title":"Effects of ramelteon on refractory behavioral and psychological symptoms of Alzheimer's disease","volume":"33","author":"Asano","year":"2013","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1272\/jnms.70.334","article-title":"Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia","volume":"70","author":"Asayama","year":"2003","journal-title":"Journal of Nippon Medical School"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0016|cit16","first-page":"1563","article-title":"Methods and problems of clinical psychopharmacology. Results of a double blind study with Medazepam and placebo in geriatric psychiatry","volume":"18","author":"Bergener","year":"1968","journal-title":"Arzneimittel-Forschung"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0017|cit17","first-page":"403","article-title":"Tryptophan and sleep in subjects with neuropsychiatric syndromes","volume":"43","author":"Bergonzi","year":"1973","journal-title":"Rivista di Neurologia"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/gps.4839","article-title":"Effects of pain treatment on sleep in nursing home patients with dementia and depression: a multicenter placebo-controlled randomized clinical trial","volume":"33","author":"Blytt","year":"2018","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fpsyg.2018.00134","article-title":"Long-term pain treatment did not improve sleep in nursing home patients with comorbid dementia and depression: a 13-week randomized placebo-controlled trial","volume":"9","author":"Blytt","year":"2018","journal-title":"Frontiers in Psychology"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/antiox3020245","article-title":"Melatonin therapy in patients with Alzheimer's disease","volume":"2","author":"Cardinali","year":"2014","journal-title":"Antioxidants"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-4943(00)00068-6","article-title":"Melatonin for treatment of sundowning in elderly persons with dementia - a preliminary study","volume":"31","author":"Cohen-Mansfield","year":"2000","journal-title":"Archives of Gerontology and Geriatrics"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0022|cit22","first-page":"243","article-title":"Melatonin effects on macro sleep architecture in Alzheimer's disease patients","volume":"36","author":"Cruz-Aguilar","year":"2013","journal-title":"Salud Mental"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0023|cit23","unstructured":"Eeles E The effect of melatonin on sleep pattern and levels of agitation in patients with dementia National Research Register 2003"},{"issue":"2","key":"10.1002\/14651858.CD009178.pub4-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/JGP.0b013e318187de18","article-title":"Melatonin fails to improve sleep or agitation in a double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer's disease","volume":"17","author":"Gehrmann","year":"2009","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/j.1532-5415.1997.tb03794.x","article-title":"Tacrine for treatment of sleep disturbance in dementia","volume":"45","author":"Gillman","year":"1997","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/geronj\/31.4.419","article-title":"Caffeine in the 'Sundown syndrome'. Report of negative results","volume":"31","author":"Ginsburg","year":"1976","journal-title":"Journal of Gerontology"},{"issue":"2","key":"10.1002\/14651858.CD009178.pub4-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/0004867417747402","article-title":"Suvorexant for the treatment of insomnia in patients with Alzheimer's disease","volume":"52","author":"Hamuro","year":"2018","journal-title":"Australian & New Zealand Journal of Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0028|cit28","unstructured":"Haworth J A pilot, double-blind, placebo controlled, parallel group study of the effect of melatonin treatment in patients with Alzheimer's disease and sleep National Research Register Archive 2001"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/gps.1305","article-title":"Does modafinil have the potential to improve disrupted sleep patterns in patients with dementia?","volume":"20","author":"Howcroft","year":"2005","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1176\/ajp.156.7.1116","article-title":"Improvement of sleep and behavior by methylphenidate in Alzheimer's disease","volume":"156","author":"Kittur","year":"1999","journal-title":"American Journal of Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000468423","article-title":"Efficacy and side effects of chloral hydrate and tryptophan as sleeping aids in psychogeriatric patients","volume":"15","author":"Linnoila","year":"1980","journal-title":"International Pharmacopsychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000468424","article-title":"Efficacy and side effects of lorazepam, oxazepam, and temazepam as sleeping aids in psychogeriatric in-patients","volume":"15","author":"Linnoila","year":"1980","journal-title":"International Pharmacopsychiatry"},{"issue":"6","key":"10.1002\/14651858.CD009178.pub4-BIB0033|cit33","first-page":"387","article-title":"A controlled trial of chlormethiazole in the management of symptoms of the organic dementias in the elderly","volume":"1","author":"Magnus","year":"1978","journal-title":"Clinical Therapeutics"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/01.jcp.0000132443.12607.fd","article-title":"Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease:\u202d \u202can open-label pilot study using actigraphy","volume":"24","author":"Mahlberg","year":"2004","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/sleep\/26.5.602","article-title":"Sleep-related outcomes in persons with mild to moderate Alzheimer disease in a placebo-controlled trial of galantamine","volume":"26","author":"Markowitz","year":"2003","journal-title":"Sleep"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/0891988704264535","article-title":"Risperidone is effective for wandering and disturbed sleep\/wake patterns in Alzheimer's disease","volume":"17","author":"Meguro","year":"2004","journal-title":"Journal of Geriatric Psychiatry and Neurology"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0037|cit37","first-page":"227","article-title":"Effect of methylcobalamin (VB12) injection on sleep-wake rhythm in demented patients","volume":"46","author":"Mishima","year":"1992","journal-title":"Japanese Journal of Psychiatry & Neurology"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0038|cit38","first-page":"A351","article-title":"Six-month donepezil treatment alters REM sleep parameters in Alzheimer's disease patients: a double-blind placebo controlled study","volume":"26","author":"Moraes","year":"2003","journal-title":"Sleep"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/sleep\/29.2.199","article-title":"The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: a double-blind placebo-controlled study","volume":"29","author":"Moraes","year":"2006","journal-title":"Sleep"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0040|cit40","unstructured":"A study of the effects on sleep, attention, and gastrointestinal tolerance of galantamine and donepezil in patients with Alzheimer's disease clinicaltrials.gov\/show\/NCT00035204"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0041|cit41","unstructured":"Quetiapine for the treatment of insomnia in Alzheimer's disease clinicaltrials.gov\/show\/NCT00232570"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0042|cit42","unstructured":"The effect of anticholinesterase drugs on sleep in Alzheimer's disease patients clinicaltrials.gov\/show\/NCT00480870"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0043|cit43","unstructured":"Modafinil treatment for sleep\/wake disturbances in older adults clinicaltrials.gov\/show\/NCT00626210"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0044|cit44","unstructured":"Safety and feasibility of sodium oxybate in mild Alzheimer's disease patients clinicaltrials.gov\/show\/NCT00706186"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0045|cit45","unstructured":"Efficacy of Circadin\u00ae 2 mg in patients with mild to moderate Alzheimer disease treated with AChE inhibitor clinicaltrials.gov\/show\/NCT00940589"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0046|cit46","unstructured":"A study of the safety and tolerability of AZD5213 effect on sleep for patients with Alzheimer's\/cognitive impairment clinicaltrials.gov\/show\/NCT01548287"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0047|cit47","unstructured":"SYN120 study to evaluate its safety, tolerability and efficacy in Parkinson's disease dementia (SYNAPSE) clinicaltrials.gov\/ct2\/show\/study\/NCT02258152"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0006-3223(93)90128-Z","article-title":"THA does not affect sleep or EEG spectral power in Alzheimer's disease","volume":"33","author":"Petit","year":"1993","journal-title":"Biological Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1001\/jama.299.22.2642","article-title":"Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial","volume":"299","author":"Riemersma-van der Lek","year":"2008","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0091-3057(95)00116-E","article-title":"Triazolam in Alzheimer's disease: pilot study on sleep and memory effects","volume":"52","author":"Riley McCarten","year":"1995","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1532-5415.2004.52470.x","article-title":"Effect of antipsychotic withdrawal on behavior and sleep\/wake activity in nursing home residents with dementia: a randomized, placebo-controlled, double-blinded study","volume":"52","author":"Ruths","year":"2004","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0052|cit52","first-page":"59","article-title":"Hydroxyzine for acute treatment of agitation and insomnia in organic mental disorder","volume":"9","author":"Schubert","year":"1984","journal-title":"Psychiatric Journal of the University of Ottawa"},{"issue":"2","key":"10.1002\/14651858.CD009178.pub4-BIB0053|cit53","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/psyg.12191","article-title":"Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double-blind, placebo-controlled pilot study","volume":"17","author":"Scoralick","year":"2017","journal-title":"Psychogeriatrics"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10354-007-0427-5","article-title":"Effects of Ginkgo biloba extract EGb 761 on neuropsychiatric symptoms of dementia: findings from a randomised controlled trial","volume":"157","author":"Scripnikov","year":"2007","journal-title":"Wiener Medizinische Wochenschrift"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/030006059202000207","article-title":"A double-blind, comparative study of zolpidem and placebo in the treatment of insomnia in elderly psychiatric in-patients","volume":"20","author":"Shaw","year":"1992","journal-title":"Journal of International Medical Research"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.pnpbp.2007.12.027","article-title":"Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia","volume":"32","author":"Shinno","year":"2008","journal-title":"Progress in Neuro-Psychopharmacology\u202d & \u202cBiological Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0057|cit57","first-page":"233","article-title":"Use of combined treatment with melatonin and clomethiazole in circadian rhythm sleep disorder in the elderly with dementia","volume":"44","author":"Simon Padilla","year":"2009","journal-title":"Revista Espanola de Geriatria y Gerontologia"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0058|cit58","first-page":"144S","article-title":"Modafinil vs. placebo: effects on daytime sleep in Alzheimer's disease","volume":"61","author":"Singer","year":"2007","journal-title":"Biological Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1185\/030079904125003214","article-title":"Examination of nighttime sleep-related problems during double-blind, placebo-controlled trials of galantamine in patients with Alzheimer's disease","volume":"20","author":"Stahl","year":"2004","journal-title":"Current Medical Research and Opinion"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0060|cit60","first-page":"804","article-title":"A phase 2 study to investigate the effects of Sar110894 on cognition, daily function, apathy and sleep in mild to moderate Alzheimer's disease patients","author":"Stemmelin","year":"2013","journal-title":"Journal of Nutrition, Health and Aging"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0061|cit61","unstructured":"Tozawa T \u202d \u202cMishima K \u202d \u202cSatoh K \u202d \u202cMatsumoto Y \u202d \u202cEchizenya M \u202d \u202cSasaki M Melatonin replacement therapy for rest-activity rhythm disorders in patients with senile dementia of Alzheimer's type \u202c21st Collegium Internationale Neuropsychopharmacologium\u202d (\u202cCINP\u202d) \u202cCongress; 1998 Jul\u202d \u202c12-16\u202d; Glasgow,\u202d \u202cScotland 1998"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0062|cit62","unstructured":"Study of the influences of Yokukansan for sleep disturbance in dementia wwwwhoint\/trialsearch\/Trial2aspx?TrialID=JPRN-UMIN000006251"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0063|cit63","unstructured":"Investigation on the effects of memantine on psychiatric symptoms and sleep disturbances in patients with Alzheimer's disease upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=R000007581"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0064|cit64","unstructured":"The controlled study of medical treatment for the sleep disturbance in dementia upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=R000019016"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0065|cit65","unstructured":"Evaluation of cognitive, affective, olfactory functions and sleep disturbance improvement in dementia with Lewy bodies patients treated with galantamine wwwwhoint\/trialsearch\/Trial2aspx?TrialID=JPRN-UMIN000022860"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/08039480510023034","article-title":"Effects of melatonin-rich night-time milk on sleep and activity in elderly institutionalized subjects","volume":"59","author":"Valtonen","year":"2005","journal-title":"Nordic Journal of Psychiatry"},{"issue":"2","key":"10.1002\/14651858.CD009178.pub4-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/JCP.0b013e31820e861c","article-title":"Randomized, controlled, crossover trial of dronabinol, 2.5mg, for agitation in 2 patients with dementia","volume":"31","author":"Walther","year":"2011","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/00207459609070833","article-title":"Essential fatty acids preparation (sr-3) improves Alzheimer's patients quality of life","volume":"87","author":"Yehuda","year":"1996","journal-title":"International Journal of Neuroscience"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0069|cit69","unstructured":"Clinical study on safety and effectiveness of Ukgansan ga jinpibanha for insomnia: safety and effectiveness (a randomized controlled, double-blind, parallel study, pilot study) cris.nih.go.kr\/cris\/en\/search\/search_result_st01.jsp?seq=10276"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0070|cit70","unstructured":"Zolpidem CR and hospitalized patients with dementia clinicaltrials.gov\/ct2\/show\/NCT00814502"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0071|cit71","unstructured":"Study evaluating nelotanserin for treatment of REM sleep behavior disorder in subjects with dementia (DLB or PDD) clinicaltrials.gov\/ct2\/show\/NCT02708186"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0072|cit72","unstructured":"Z-drugs for sleep disorders in Alzheimer's disease clinicaltrials.gov\/ct2\/show\/NCT03075241"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0073|cit73","unstructured":"Nighttime agitation and restless legs syndrome in people with Alzheimer's disease clinicaltrials.gov\/ct2\/show\/NCT03082755"},{"issue":"2","key":"10.1002\/14651858.CD009178.pub4-BIB0074|cit74","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jamda.2013.09.012","article-title":"Reasons for institutionalization of people with dementia: informal caregiver reports from 8 European countries","volume":"15","author":"Afram","year":"2014","journal-title":"JAMDA"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/sleep\/20.1.24","article-title":"Use of wrist actigraphy for monitoring sleep\/wake in demented nursing home patients","volume":"20","author":"Ancoli-Israel","year":"1997","journal-title":"Sleep"},{"issue":"3","key":"10.1002\/14651858.CD009178.pub4-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000326238","article-title":"Sleep disturbance in dementia with Lewy bodies and Alzheimer's disease: a multicenter analysis","volume":"31","author":"Bliwise","year":"2011","journal-title":"Dementia & Geriatric Cognitive Disorders"},{"issue":"2","key":"10.1002\/14651858.CD009178.pub4-BIB0077|cit77","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/jsr.12371","article-title":"The two-process model of sleep regulation: a reappraisal","volume":"25","author":"Borb\u00e9ly","year":"2016","journal-title":"Journal of Sleep Research"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/sleep\/23.7.1g","article-title":"A benzodiazepine hypnotic facilitates adaptation of circadian rhythms and sleep-wake homeostasis to an eight hour delay shift simulating westward jet lag","volume":"23","author":"Buxton","year":"2000","journal-title":"Sleep"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.smrv.2013.01.006","article-title":"Wrist actigraphy for measuring sleep in intervention studies with Alzheimer's disease patients: application, usefulness and challenges","volume":"17","author":"Camargos","year":"2013","journal-title":"Sleep Medicine Reviews"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/157015910792246209","article-title":"Clinical aspects of melatonin intervention in Alzheimer's disease progression","volume":"8","author":"Cardinali","year":"2010","journal-title":"Current Neuropharmacology"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0740-5472(91)90025-6","article-title":"Benzodiazepines and the elderly: a review of potential problems","volume":"8","author":"Closser","year":"1991","journal-title":"Journal of Substance Abuse Treatment"},{"issue":"28","key":"10.1002\/14651858.CD009178.pub4-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta15280","article-title":"A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database","volume":"15","author":"Coupland","year":"2011","journal-title":"Health Technology Assessment"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2165\/00023210-200317110-00004","article-title":"Benzodiazepines and risk of hip fractures in older people: a review of the evidence","volume":"17","author":"Cumming","year":"2003","journal-title":"CNS Drugs"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1099-1166(199804)13:4<248::AID-GPS770>3.0.CO;2-0","article-title":"Determinants of carer stress in Alzheimer's disease","volume":"13","author":"Donaldson","year":"1998","journal-title":"International Journal of Geriatric Psychiatry"},{"issue":"10","key":"10.1002\/14651858.CD009178.pub4-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1136\/jnnp.2004.056408","article-title":"Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia","volume":"76","author":"Cummings","year":"2005","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD009178.pub4-BIB0086|cit86","first-page":"56","article-title":"Effect of melatonin on mild Alzheimer's disease in elderly male patients","volume":"23","author":"Gao","year":"2009","journal-title":"Practical Geriatrics"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/geronb\/55.4.P247","article-title":"Predictors of institutionalization of cognitively impaired elders: family help and the timing of placement","volume":"55","author":"Gaugler","year":"2000","journal-title":"Journals of Gerontology. Series B, Psychological Sciences and Social Sciences"},{"issue":"1","key":"10.1002\/14651858.CD009178.pub4-BIB0088|cit88","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.gerinurse.2017.06.003","article-title":"Impact of Alzheimer disease patients' sleep disturbances on their caregivers","volume":"39","author":"Gehrman","year":"2018","journal-title":"Geriatric Nursing"},{"issue":"1","key":"10.1002\/14651858.CD009178.pub4-BIB0089|cit89","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jalz.2016.04.002","article-title":"Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011-2013","volume":"13","author":"Goodman","year":"2017","journal-title":"Alzheimer's & Dementia"},{"issue":"1","key":"10.1002\/14651858.CD009178.pub4-BIB0090|cit90","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000335363","article-title":"Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian cross-sectional study on 431 patients","volume":"33","author":"Guarnieri","year":"2012","journal-title":"Dementia & Geriatric Cognitive Disorders"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"11","key":"10.1002\/14651858.CD009178.pub4-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/gps.1013","article-title":"A retrospective study of the behavioural and psychological symptoms of mid and late phase Alzheimer's disease","volume":"18","author":"Hart","year":"2003","journal-title":"International Journal of Geriatric Psychiatry"},{"issue":"7","key":"10.1002\/14651858.CD009178.pub4-BIB0093|cit93","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.jagp.2017.03.004","article-title":"Suvorexant in elderly patients with insomnia: pooled analyses of data from Phase III randomized controlled clinical trials","volume":"25","author":"Herring","year":"2017","journal-title":"American Journal of Psychiatry"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0094|cit94","unstructured":"Higgins JP Altman DG Sterne JA Chapter 8: Assessing risk of bias in included studies. In: Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"8","key":"10.1002\/14651858.CD009178.pub4-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/gps.2607","article-title":"Determining the minimum clinically important differences for outcomes in the DOMINO trial","volume":"26","author":"Howard","year":"2011","journal-title":"International Journal of Geriatric Psychiatry"},{"issue":"S1","key":"10.1002\/14651858.CD009178.pub4-BIB0096|cit96","doi-asserted-by":"publisher","first-page":"A123","DOI":"10.1093\/sleep\/zsz067.300","article-title":"Interaction between the progression of Alzheimer's dementia and circadian disturbances: a 13-year longitudinal study in community-based older adults","volume":"42","author":"Li","year":"2019","journal-title":"Sleep"},{"issue":"12","key":"10.1002\/14651858.CD009178.pub4-BIB0097|cit97","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1001\/jamaneurol.2014.2510","article-title":"Orexineric system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease","volume":"71","author":"Liguori","year":"2014","journal-title":"JAMA Neurology"},{"issue":"5","key":"10.1002\/14651858.CD009178.pub4-BIB0098|cit98","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1176\/appi.ajp.157.5.708","article-title":"Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging","volume":"157","author":"Lyketsos","year":"2000","journal-title":"American Journal of Psychiatry"},{"issue":"3","key":"10.1002\/14651858.CD009178.pub4-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1081\/CBI-100101055","article-title":"Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons","volume":"17","author":"Mishima","year":"2000","journal-title":"Chronobiology International"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0100|cit100","unstructured":"National Institute for Health and Care Excellence Dementia: assessment, management and support for people living with dementia and their carers www.nice.org.uk\/guidance\/ng97"},{"key":"10.1002\/14651858.CD009178.pub4-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1345\/aph.1Q589","article-title":"Psychotropic-related hip fractures: meta-analysis of first-generation and second-generation antidepressant and antipsychotic drugs","volume":"46","author":"Oderda","year":"2012","journal-title":"Annals of Pharmacotherapy"},{"issue":"4","key":"10.1002\/14651858.CD009178.pub4-BIB0102|cit102","first-page":"327","article-title":"Should melatonin be used as a sleeping aid for elderly people?","volume":"72","author":"Papillon-Ferland","year":"2019","journal-title":"Canadian Journal of Hospital Pharmacy"},{"issue":"3","key":"10.1002\/14651858.CD009178.pub4-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1532-5415.2010.02733.x","article-title":"Frequency and correlates of caregiver-reported sleep disturbances in a sample of persons with early dementia","volume":"58","author":"Rongve","year":"2010","journal-title":"Journal of the American Geriatrics Society"},{"issue":"15","key":"10.1002\/14651858.CD009178.pub4-BIB0104|cit104","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1001\/jama.294.15.1934","article-title":"Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials","volume":"294","author":"Schneider","year":"2005","journal-title":"JAMA"},{"issue":"3","key":"10.1002\/14651858.CD009178.pub4-BIB0105|cit105","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/01.JGP.0000200589.01396.6d.","article-title":"Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials","volume":"14","author":"Schneider","year":"2006","journal-title":"American Journal of Geriatric Psychiatry"},{"issue":"4","key":"10.1002\/14651858.CD009178.pub4-BIB0106|cit106","doi-asserted-by":"publisher","first-page":"zsz017","DOI":"10.1093\/sleep\/zsz017","article-title":"Sleep-wake regulation and the hallmarks of the pathogenesis of Alzheimer's disease","volume":"42","author":"Van Egroo","year":"2019","journal-title":"Sleep"},{"issue":"9","key":"10.1002\/14651858.CD009178.pub4-BIB0107|cit107","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011881","article-title":"Non-pharmacological interventions for sleep disturbances in people with dementia","author":"Wilfling","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD009178.pub4-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/1533317514568005","article-title":"Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials","volume":"30","author":"Xu","year":"2015","journal-title":"American Journal of Alzheimer's Disease and Other Dementias"},{"issue":"3","key":"10.1002\/14651858.CD009178.pub4-BIB0109|cit109","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009178.pub2","article-title":"Pharmacotherapies for sleep disturbances in Alzheimer's disease","author":"McCleery","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD009178.pub4-BIB0110|cit110","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009178.pub3","article-title":"Pharmacotherapies for sleep disturbances in dementia","author":"McCleery","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T21:45:41Z","timestamp":1669585541000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD009178.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Dementia and Cognitive Improvement Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,15]]},"references-count":110,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd009178.pub4","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,15]]}}}