{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:31:20Z","timestamp":1788690680926,"version":"build-2803163510"},"update-to":[{"DOI":"10.1002\/14651858.cd009197.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000}}],"reference-count":115,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd009197.pub3","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T14:25:58Z","timestamp":1510064758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis"],"prefix":"10.1002","author":[{"given":"Chunjie","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University; Department of Head and Neck Oncology; No. 14, Section Three, Ren Min Nan Road Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongkai","family":"Lv","sequence":"additional","affiliation":[{"name":"Nan Chong Central Hospital, Second Clinical Medical College of Chuan Bei Medical College; Department of Stomatology; No. 66 , Da Bei Jie Road Nanchong Sichuan China 637000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongdao","family":"Shi","sequence":"additional","affiliation":[{"name":"West China Hospital of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases; Department of Oral and Maxillofacial Surgery; No. 14, Section Three, Ren Min Nan Road Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhu","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University; Department of Cardiovascular Disease; No 37, Guo Xue Xiang Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Wu","sequence":"additional","affiliation":[{"name":"West China Hospital of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases; Department of Periodontology; No. 14, Section Three, Ren Min Nan Road Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjiang","family":"Li","sequence":"additional","affiliation":[{"name":"West China Hospital of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases; Department of Head and Neck Oncology; No. 14, Section Three, Ren Min Nan Road Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zipporah","family":"Iheozor-Ejiofor","sequence":"additional","affiliation":[{"name":"The University of Manchester, Manchester Academic Health Science Centre; Division of Nursing, Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health; Jean McFarlane Building Oxford Road Manchester UK M13 9PL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1902\/jop.2008.070223","article-title":"The Periodontitis and Vascular Events (PAVE) pilot study: adverse events","volume":"79","author":"Beck","year":"2008","journal-title":"Journal of Periodontology"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1902\/jop.2008.070216","article-title":"The Periodontitis and Vascular Events (PAVE) pilot study: recruitment, retention, and community care controls","volume":"79","author":"Couper","year":"2008","journal-title":"Journal of Periodontology"},{"issue":"2","key":"10.1002\/14651858.CD009197.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1902\/jop.2009.080007","article-title":"Results from the Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease","volume":"80","author":"Offenbacher","year":"2009","journal-title":"Journal of Periodontology"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0004|cit4","unstructured":"van Dyke TE Maupome G Madden T Grossi S Gunsolley JC Offenbacher S Periodontal Intervention for Cardiac Events: A Pilot Trial (Periodontitis and Cardiovascular Events or \"PAVE\") www.ClinicalTrials.gov 2003"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0005|cit5","unstructured":"Amar S Systemic Endothelial Consequences of Periodontal Disease (Impact of Gum Infection on Heart Disease) www.ClinicalTrials.gov 2004"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1600-051X.2012.01942.x","article-title":"Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial","volume":"39","author":"Bokhari","year":"2012","journal-title":"Journal of Clinical Periodontology"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/01.ATV.0000121571.78696.dc","article-title":"Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial","volume":"24","author":"Brown","year":"2004","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0008|cit8","unstructured":"Cullinan M Carle A The Effect of a Triclosan Containing Dentifrice on the Relationship Between Periodontal Disease and Cardiovascular Disease (Cardiovascular and Periodontal Study: a Randomised Controlled Trial CAPS) www.anzctr.org.au 2005"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.scitotenv.2014.11.052","article-title":"The influence of a triclosan toothpaste on adverse events in patients with cardiovascular disease over 5-years","volume":"508","author":"Cullinan","year":"2015","journal-title":"Sci Total Environ"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/154405910508400312","article-title":"Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol","volume":"84","author":"D'Aiuto","year":"2005","journal-title":"Journal of Dental Research"},{"issue":"5","key":"10.1002\/14651858.CD009197.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.ahj.2005.06.018","article-title":"Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial","volume":"151","author":"D'Aiuto","year":"2006","journal-title":"American Heart Journal"},{"issue":"11 Suppl","key":"10.1002\/14651858.CD009197.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1902\/jop.2005.76.11-S.2175","article-title":"Associations between periodontal disease and systemic disease: evaluating the strength of the evidence","volume":"76","author":"Dietrich","year":"2005","journal-title":"Journal of Periodontology"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/lsm.20873","article-title":"IL-1beta, TNF-alpha, total antioxidative status and microbiological findings in chronic periodontitis treated with fluorescence-controlled Er:YAG laser radiation","volume":"42","author":"Dom\u00ednguez","year":"2010","journal-title":"Lasers in Surgery and Medicine"},{"issue":"2","key":"10.1002\/14651858.CD009197.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x","article-title":"Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis","volume":"107","author":"Ebersole","year":"1997","journal-title":"Clinical and Experimental Immunology"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1902\/jop.2010.090628","article-title":"Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 fatty acids and low-dose aspirin","volume":"81","author":"El-Sharkawy","year":"2010","journal-title":"Journal of Periodontology"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ahj.2005.10.002","article-title":"The effects of periodontal therapy on vascular endothelial function: a pilot trial","volume":"151","author":"Elter","year":"2006","journal-title":"American Heart Journal"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1902\/jop.2010.100036","article-title":"Subantimicrobial-dose doxycycline and cytokine-chemokine levels in gingival crevicular fluid","volume":"82","author":"Emingil","year":"2011","journal-title":"Journal of Periodontology"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1600-051X.2010.01619.x","article-title":"Effect of atorvastatin on chronic periodontitis: a randomized pilot study","volume":"37","author":"Fajardo","year":"2010","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0019|cit19","first-page":"1405","article-title":"Subantimicrobial doxycycline reduces biomarkers of systemic inflammation in heart disease and diabetes","volume":"74","author":"Golub","year":"2003","journal-title":"Journal of Periodontology"},{"issue":"9","key":"10.1002\/14651858.CD009197.pub3-BIB0020|cit20","first-page":"84","article-title":"Antimicrobial host response therapy in periodontics: a modern way to manage disease","volume":"25","author":"Gottehrer","year":"2006","journal-title":"Dentistry Today"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0021|cit21","first-page":"74, 76, 78 pass","article-title":"Antimicrobial host response therapy in periodontics: a modern way to manage disease, part 2","volume":"26","author":"Gottehrer","year":"2007","journal-title":"Dentistry Today"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0022|cit22","first-page":"100, 102, 104","article-title":"The standard of care for nonsurgical periodontal treatment for reducing the dental risk for cardiac disease","volume":"26","author":"Gottehrer","year":"2007","journal-title":"Dentistry Today"},{"issue":"12","key":"10.1002\/14651858.CD009197.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1902\/jop.2011.110002","article-title":"Effect of phase I periodontal therapy on anti-cardiolipin antibodies in patients with acute myocardial infarction associated with chronic periodontitis","volume":"82","author":"Gunupati","year":"2011","journal-title":"Journal of Periodontology"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1034\/j.1600-051X.2003.00282.x","article-title":"Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses","volume":"30","author":"Ide","year":"2003","journal-title":"Journal of Clinical Periodontology"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1902\/jop.2004.75.3.420","article-title":"The short-term effects of treatment of chronic periodontitis on circulating levels of endotoxin, C-reactive protein, tumor necrosis factor-alpha, and interleukin-6","volume":"75","author":"Ide","year":"2004","journal-title":"Journal of Periodontology"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0026|cit26","first-page":"616","article-title":"Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis","volume":"46","author":"Kamil","year":"2011","journal-title":"Journal of Periodontal Research"},{"issue":"7","key":"10.1002\/14651858.CD009197.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/SMJ.0b013e318038fa4d","article-title":"Periodontitis and cardiovascular disease: periodontal treatment lowers plasma cholesterol","volume":"100","author":"L\u00f6sche","year":"2007","journal-title":"Southern Medical Journal"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1902\/jop.2009.090236","article-title":"Serum inflammatory mediators in pregnancy: changes after periodontal treatment and association with pregnancy outcomes","volume":"80","author":"Michalowicz","year":"2009","journal-title":"Journal of Periodontology"},{"issue":"12","key":"10.1002\/14651858.CD009197.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1902\/jop.2006.060047","article-title":"Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot study","volume":"77","author":"Offenbacher","year":"2006","journal-title":"Journal of Periodontology"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1902\/jop.2009.080447","article-title":"Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors","volume":"80","author":"Ortiz","year":"2009","journal-title":"Journal of Periodontology"},{"issue":"7","key":"10.1002\/14651858.CD009197.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/SMJ.0b013e31802fa327","article-title":"Beneficial effects of periodontal treatment on metabolic control of hypercholesterolemia","volume":"100","author":"Oz","year":"2007","journal-title":"Southern Medical Journal"},{"issue":"2","key":"10.1002\/14651858.CD009197.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.atherosclerosis.2005.11.019","article-title":"Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis","volume":"188","author":"Paju","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0033|cit33","unstructured":"Quintero A Valenzuela CY Ibieta C Jara L Llancaqueo M Lopez NJ Effects of Periodontal Therapy on Markers of Systemic Inflammation in Subjects at Cardiovascular Disease Risk (Effects of Periodontal Therapy on Systemic Inflammation) www.ClinicalTrials.gov 2010"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0034|cit34","unstructured":"Contreras A Ramirez JH Impact of Periodontal Therapy on Endothelial Function (Periodontal Infection and Endothelial Dysfunction) www.ClinicalTrials.gov 2008"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1745-6215-12-46","article-title":"Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial","volume":"12","author":"Ram\u00edrez","year":"2011","journal-title":"Trials"},{"issue":"12","key":"10.1002\/14651858.CD009197.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.archoralbio.2010.08.001","article-title":"Changes of adiponectin and inflammatory cytokines after periodontal intervention in type 2 diabetes patients with periodontitis","volume":"55","author":"Sun","year":"2010","journal-title":"Archives of Oral Biology"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1600-0722.2010.00748.x","article-title":"The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial","volume":"118","author":"Taylor","year":"2010","journal-title":"European Journal of Oral Sciences"},{"issue":"9","key":"10.1002\/14651858.CD009197.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa063186","article-title":"Treatment of periodontitis and endothelial function","volume":"356","author":"Tonetti","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"8","key":"10.1002\/14651858.CD009197.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1600-051X.2007.01104.x","article-title":"Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease","volume":"34","author":"T\u00fcter","year":"2007","journal-title":"Journal of Clinical Periodontology"},{"issue":"8","key":"10.1002\/14651858.CD009197.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1902\/jop.2010.090694","article-title":"Effects of scaling and root planing and subantimicrobial dose doxycycline on gingival crevicular fluid levels of matrix metalloproteinase-8, -13 and serum levels of HsCRP in patients with chronic periodontitis","volume":"81","author":"T\u00fcter","year":"2010","journal-title":"Journal of Periodontology"},{"issue":"7","key":"10.1002\/14651858.CD009197.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1600-051X.2005.00775.x","article-title":"Effects of single-visit full-mouth ultrasonic debridement versus quadrant-wise ultrasonic debridement","volume":"32","author":"Koshy","year":"2005","journal-title":"Journal of Clinical Periodontology"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1600-051X.2008.01316.x","article-title":"Changes in serum interleukin-6, C-reactive protein and thrombomodulin levels under periodontal ultrasonic debridement","volume":"35","author":"Ushida","year":"2008","journal-title":"Journal of Clinical Periodontology"},{"issue":"5","key":"10.1002\/14651858.CD009197.pub3-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1902\/jop.2009.080471","article-title":"Periodontal therapy reduces plasma levels of interleukin-6, C-reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial hypertension","volume":"80","author":"Vidal","year":"2009","journal-title":"Journal of Periodontology"},{"issue":"10","key":"10.1002\/14651858.CD009197.pub3-BIB0044|cit44","first-page":"1125","article-title":"The importance of periodontal treatment in patients with cardiovascular diseases","volume":"67","author":"Wozakowska-Kap\u0142on","year":"2009","journal-title":"Kardiologia Polska"},{"issue":"10","key":"10.1002\/14651858.CD009197.pub3-BIB0045|cit45","first-page":"1176","article-title":"The impact of periodontal treatment on serum hs-CRP of patient with both periodontitis and cardiovascular disease","volume":"8","author":"Yuan","year":"2010","journal-title":"Chinese Journal of Integrative Medicine on Cardio-\/Cerebrovascular Disease"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0046|cit46","first-page":"1408","article-title":"Association of full-mouth subgingival scaling and root planning and quadrant subgingival scaling and root planning with systemic acute inflammatory reaction","volume":"30","author":"Zhao","year":"2010","journal-title":"Journal of Shanghai Jiaotong University (Medical Science)"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"262","DOI":"10.14219\/jada.archive.2011.0165","article-title":"The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial","volume":"142","author":"Payne","year":"2011","journal-title":"Journal of the American Dental Association"},{"issue":"9","key":"10.1002\/14651858.CD009197.pub3-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1600-051X.2007.01115.x","article-title":"Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women","volume":"34","author":"Payne","year":"2007","journal-title":"Journal of Clinical Periodontology"},{"issue":"7","key":"10.1002\/14651858.CD009197.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00011-013-0626-z","article-title":"Subantimicrobial-dose doxycycline treatment increases serum cholesterol efflux capacity from macrophages","volume":"62","author":"Salminen","year":"2013","journal-title":"Inflammation Research"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0050|cit50","unstructured":"Azhar M Khan AA Bokhari SAH Influence of Periodontal Treatment on Systemic Inflammatory Mediators: hsC-reactive Protein, Fibrinogen and White Blood Cells in CHD Patients (Influence of Periodontal Treatment on Systemic Inflammatory Mediators Perio-CHD) www.ClinicalTrials.gov 2010"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0051|cit51","unstructured":"Haas AN Periodontal Therapy in Coronary Artery Patients (PerioCardio) www.ClinicalTrials.gov 2013"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1186\/1471-2458-11-729","article-title":"The effect of a periodontal intervention on cardiovascular risk markers in Indigenous Australians with periodontal disease: the PerioCardio study","volume":"11","author":"Skilton","year":"2011","journal-title":"BMC Public Health"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0053|cit53","first-page":"7","article-title":"International workshop for classification of periodontal diseases and conditions","volume":"4","author":"American Academy of","year":"1999","journal-title":"Annals of Periodontology"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Annals of Periodontology"},{"issue":"7454","key":"10.1002\/14651858.CD009197.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/bmj.328.7454.1490","article-title":"Grading quality of evidence and strength of recommendations","volume":"328","author":"Atkins","year":"2004","journal-title":"BMJ"},{"issue":"9B","key":"10.1002\/14651858.CD009197.pub3-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"13F","DOI":"10.1016\/S0002-9149(99)00209-X","article-title":"Epidemiology of hypertriglyceridemia and cardiovascular disease","volume":"83","author":"Austin","year":"1999","journal-title":"American Journal of Cardiology"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"E114","DOI":"10.25011\/cim.v30i3.1079","article-title":"Periodontal care may improve systemic inflammation","volume":"30","author":"Blum","year":"2007","journal-title":"Clinical and Investigative Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002128.pub3","article-title":"Dietary advice for reducing cardiovascular risk","author":"Brunner","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0059|cit59","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004622.pub2","article-title":"Full-mouth disinfection for the treatment of adult chronic periodontitis","author":"Eberhard","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7109","key":"10.1002\/14651858.CD009197.pub3-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"10","key":"10.1002\/14651858.CD009197.pub3-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0022034512457373","article-title":"Prevalence of periodontitis in adults in the United States: 2009 and 2010","volume":"91","author":"Eke","year":"2012","journal-title":"Journal of Dental Research"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4103\/0976-237X.137959","article-title":"Determination of the antibacterial activity of simvastatin against periodontal pathogens,Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: An in vitro study","volume":"5","author":"Emani","year":"2014","journal-title":"Contemp Clin Dent"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0063|cit63","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003875.pub3","article-title":"Enamel matrix derivative (Emdogain\u00ae) for periodontal tissue regeneration in intrabony defects","author":"Esposito","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"10.1002\/14651858.CD009197.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1902\/jop.2009.097001","article-title":"The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease","volume":"80","author":"Friedewald","year":"2009","journal-title":"Journal of Periodontology"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.14219\/jada.archive.2002.0375","article-title":"Periodontal disease and cardiovascular disease epidemiology and possible mechanisms","volume":"133 Suppl","author":"Genco","year":"2002","journal-title":"Journal of the American Dental Association"},{"issue":"7650","key":"10.1002\/14651858.CD009197.pub3-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"33","key":"10.1002\/14651858.CD009197.pub3-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"e7835","DOI":"10.1097\/MD.0000000000007835","article-title":"Age threshold for moderate and severe periodontitis among Korean adults without diabetes mellitus, hypertension, metabolic syndrome, and\/or obesity","volume":"96","author":"Han","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.amjcard.2016.05.036","article-title":"Relation of Periodontitis to Risk of Cardiovascular and All-Cause Mortality (from a Danish Nationwide Cohort Study)","volume":"118","author":"Hansen","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pathol.1.110304.100100","article-title":"Inflammation and atherosclerosis","volume":"1","author":"Hansson","year":"2006","journal-title":"Annual Review of Pathology"},{"issue":"10","key":"10.1002\/14651858.CD009197.pub3-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1902\/jop.2000.71.10.1554","article-title":"Identification of periodontal pathogens in atheromatous plaques","volume":"71","author":"Haraszthy","year":"2000","journal-title":"Journal of Periodontology"},{"issue":"5","key":"10.1002\/14651858.CD009197.pub3-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.2041-1014.2010.00582.x","article-title":"Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways","volume":"25","author":"Hayashi","year":"2010","journal-title":"Molecular Oral Microbiology"},{"issue":"12","key":"10.1002\/14651858.CD009197.pub3-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1056\/NEJM199903253401204","article-title":"Passive smoking and the risk of coronary heart disease--a meta-analysis of epidemiologic studies","volume":"340","author":"He","year":"1999","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1128\/IAI.39.3.1457-1469.1983","article-title":"Aggregation of human platelets and adhesion of Streptococcus sanguis","volume":"39","author":"Herzberg","year":"1983","journal-title":"Infection and Immunity"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1902\/jop.1996.67.10s.1138","article-title":"Effects of oral flora on platelets: possible consequences in cardiovascular disease","volume":"67 Suppl 10","author":"Herzberg","year":"1996","journal-title":"Journal of Periodontology"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1902\/jop.2005.76.11-S.2101","article-title":"Oral streptococci and cardiovascular disease: searching for the platelet aggregation-associated protein gene and mechanisms of Streptococcus sanguis-induced thrombosis","volume":"76 Suppl 11","author":"Herzberg","year":"2005","journal-title":"Journal of Periodontology"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0076|cit76","unstructured":"Higgins JP Green S editor(s) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.14219\/jada.archive.2002.0377","article-title":"Does chronic periodontitis cause coronary heart disease? A review of the literature","volume":"133 Suppl","author":"Hujoel","year":"2002","journal-title":"Journal of the American Dental Association"},{"issue":"6","key":"10.1002\/14651858.CD009197.pub3-BIB0078|cit78","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005297.pub3","article-title":"Treating periodontal disease for preventing adverse birth outcomes in pregnant women","author":"Iheozor-Ejiofor","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"10","key":"10.1002\/14651858.CD009197.pub3-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1902\/jop.2006.050443","article-title":"Effect of periodontal treatment on serum C-reactive protein levels: a systematic review and meta-analysis","volume":"77","author":"Ioannidou","year":"2006","journal-title":"Journal of Periodontology"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0080|cit80","volume-title":"Disease Control Priorities in Developing Countries","author":"Jamison","year":"2006"},{"issue":"5","key":"10.1002\/14651858.CD009197.pub3-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1067\/moe.2003.107","article-title":"Meta-analysis of periodontal disease and risk of coronary heart disease and stroke","volume":"95","author":"Janket","year":"2003","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics"},{"issue":"2","key":"10.1002\/14651858.CD009197.pub3-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/CIRCOUTCOMES.109.857771","article-title":"Arterial intima-media thickness, endothelial function, and apolipoproteins in adolescents frequently exposed to tobacco smoke","volume":"3","author":"Kallio","year":"2010","journal-title":"Circulation. Cardiovascular Quality and Outcomes"},{"issue":"8","key":"10.1002\/14651858.CD009197.pub3-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1902\/jop.2004.75.8.1046","article-title":"Periodontal diseases and the risk of coronary heart and cerebrovascular diseases: a meta-analysis","volume":"75","author":"Khader","year":"2004","journal-title":"Journal of Periodontology"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijcard.2010.11.014","article-title":"A systematic review of the effectiveness of oral health promotion activities among patients with cardiovascular disease","volume":"151","author":"Lam","year":"2010","journal-title":"International Journal of Cardiology"},{"issue":"7114","key":"10.1002\/14651858.CD009197.pub3-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/bmj.315.7114.973","article-title":"Environmental tobacco smoke exposure and ischaemic heart disease: an evaluation of the evidence","volume":"315","author":"Law","year":"1997","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"b1665","DOI":"10.1136\/bmj.b1665","article-title":"Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies","volume":"338","author":"Law","year":"2009","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0087|cit87","unstructured":"Lefebvre C Manheimer E Glanville J Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"7","key":"10.1002\/14651858.CD009197.pub3-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Medicine"},{"issue":"10","key":"10.1002\/14651858.CD009197.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1902\/jop.2014.130652","article-title":"Association of simvastatin and hyperlipidemia with periodontal status and bone metabolismmarkers","volume":"85","author":"Mag\u00e1n-Fern\u00e1ndez","year":"2014","journal-title":"J Periodontol"},{"issue":"2","key":"10.1002\/14651858.CD009197.pub3-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4103\/0970-9290.66649","article-title":"16S rRNA-based detection of oral pathogens in coronary atherosclerotic plaque","volume":"21","author":"Mahendra","year":"2010","journal-title":"Indian Journal of Dental Research"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0091|cit91","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002091.pub2","article-title":"Interventions in the management of serum lipids for preventing stroke recurrence","author":"Manktelow","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ahj.2016.07.018","article-title":"Association between periodontitis and arterial hypertension: A systematic review and meta-analysis","volume":"180","author":"Martin-Cabezas","year":"2016","journal-title":"Am Heart J"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0093|cit93","volume-title":"Periodontology","author":"Meng","year":"2009"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1196\/annals.1366.032","article-title":"Low-grade inflammation in chronic infectious diseases: paradigm of periodontal infections","volume":"1088","author":"Moutsopoulos","year":"2006","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra035098","article-title":"Cardiovascular disease","volume":"349","author":"Nabel","year":"2003","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1601-0825.2010.01759.x","article-title":"Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis","volume":"17","author":"Nakano","year":"2011","journal-title":"Oral Disease"},{"issue":"2","key":"10.1002\/14651858.CD009197.pub3-BIB0097|cit97","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001724.pub2","article-title":"Guided tissue regeneration for periodontal infra-bony defects","author":"Needleman","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD009197.pub3-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0002-8177(91)26016-X","article-title":"Variations in the prevalence and extent of periodontitis","volume":"122","author":"Oliver","year":"1991","journal-title":"Journal of the American Dental Association"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1600-0765.2006.00882.x","article-title":"Periodontal pathogens in atheromatous plaques isolated from patients with chronic periodontitis","volume":"41","author":"Padilla","year":"2006","journal-title":"Journal of Periodontal Research"},{"issue":"4","key":"10.1002\/14651858.CD009197.pub3-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1600-051X.2007.01173.x","article-title":"A systematic review and meta-analyses on C-reactive protein in relation to periodontitis","volume":"35","author":"Paraskevas","year":"2008","journal-title":"Journal of Clinical Periodontology"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/prd.12130","article-title":"Treatment of periodontal disease in older adults","volume":"72","author":"Renvert","year":"2016","journal-title":"Periodontol 2000"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0102|cit102","unstructured":"Nordic Cochrane Centre, The Cochrane Collaboration Review Manager 5 (RevMan 5) 2014"},{"issue":"5","key":"10.1002\/14651858.CD009197.pub3-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/sim.2971","article-title":"Arcsine test for publication bias in meta-analyses with binary outcomes","volume":"27","author":"R\u00fccker","year":"2008","journal-title":"Statistics in Medicine"},{"issue":"1","key":"10.1002\/14651858.CD009197.pub3-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1902\/annals.2003.8.1.54","article-title":"Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review","volume":"8","author":"Scannapieco","year":"2003","journal-title":"Annals of Periodontology"},{"issue":"8","key":"10.1002\/14651858.CD009197.pub3-BIB0105|cit105","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008367.pub2","article-title":"Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia","author":"Shi","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0106|cit106","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004714.pub3","article-title":"Treatment of periodontal disease for glycaemic control in people with diabetes mellitus","author":"Simpson","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"25","key":"10.1002\/14651858.CD009197.pub3-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1056\/NEJMoa041747","article-title":"Risk of myocardial infarction and stroke after acute infection or vaccination","volume":"351","author":"Smeeth","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD009197.pub3-BIB0108|cit108","first-page":"67","article-title":"Consensus of Chinese experts on diagnosis of severe periodontitis and treatment principles ofperiodontitis in special population","volume":"52","author":"Society of Periodontology","year":"2017","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"b4567","DOI":"10.1136\/bmj.b4567","article-title":"Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies","volume":"339","author":"Strazzullo","year":"2009","journal-title":"BMJ"},{"issue":"9","key":"10.1002\/14651858.CD009197.pub3-BIB0110|cit110","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010040","article-title":"Interventions for periodontal disease in people with rheumatoid arthritis","author":"Vergnes","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD009197.pub3-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2174\/156652406778018707","article-title":"Links between inflammation and thrombogenicity in atherosclerosis","volume":"6","author":"Viles-Gonzalez","year":"2006","journal-title":"Current Molecular Medicine"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0112|cit112","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004968.pub2","article-title":"Occlusal interventions for periodontitis in adults","author":"Weston","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD009197.pub3-BIB0113|cit113","volume-title":"Prevention of Cardiovascular Disease: Guidelines for Assessment and Management of Total Cardiovascular Risk","author":"WHO","year":"2007"},{"issue":"11","key":"10.1002\/14651858.CD009197.pub3-BIB0114|cit114","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004625.pub4","article-title":"Routine scale and polish for periodontal health in adults","author":"Worthington","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD009197.pub3-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/sj.ebd.6401110","article-title":"Priority oral health research identification for clinical decision-making","volume":"16","author":"Worthington","year":"2015","journal-title":"Evidence-based Dentistry"}],"updated-by":[{"DOI":"10.1002\/14651858.cd009197.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD009197.pub3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T22:29:12Z","timestamp":1628548152000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD009197.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Oral Health Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":115,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd009197.pub3","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD009197.pub4","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,7]]}}}