{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:42:49Z","timestamp":1777398169789,"version":"3.51.4"},"update-to":[{"DOI":"10.1002\/14651858.cd009219.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000}}],"reference-count":58,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd009219.pub4","type":"journal-article","created":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T08:45:26Z","timestamp":1474965926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Medical interventions for the prevention of platinum-induced hearing loss in children with cancer"],"prefix":"10.1002","author":[{"given":"Jorrit W","family":"van As","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology; c\/o Cochrane Childhood Cancer; Heidelberglaan 25 Utrecht Netherlands 3584 CS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Emma Children's Hospital, Amsterdam UMC, University of Amsterdam; Department of Paediatric Oncology; PO Box 22660 Amsterdam Netherlands 1100 DD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira C","family":"van Dalen","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology; Heidelberglaan 25 Utrecht Netherlands 3584 CS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"issue":"6","key":"10.1002\/14651858.CD009219.pub4-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/08880010701451244","article-title":"Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin","volume":"24","author":"Gallegos-Castorena","year":"2007","journal-title":"Pediatric Hematology and Oncology"},{"issue":"24","key":"10.1002\/14651858.CD009219.pub4-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1002\/cncr.24667","article-title":"Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group","volume":"115","author":"Katzenstein","year":"2009","journal-title":"Cancer"},{"issue":"3","key":"10.1002\/14651858.CD009219.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/00043426-200203000-00006","article-title":"Use of amifostine in the therapy of osteosarcoma in children and adolescents","volume":"24","author":"Petrilli","year":"2002","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"7","key":"10.1002\/14651858.CD009219.pub4-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1200\/JCO.2005.03.5352","article-title":"Results of the Brazilian Osteosarcoma Treatment Group Studies III and IV: prognostic factors and impact on survival","volume":"24","author":"Petrilli","year":"2006","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"10.1002\/14651858.CD009219.pub4-BIB0005|cit5","first-page":"493","article-title":"Delayed sodium thiosulfate as an otoprotectant against carboplatin-induced hearing loss in patients with malignant brain tumors","volume":"7","author":"Doolittle","year":"2001","journal-title":"Clinical Cancer Research"},{"issue":"1-2","key":"10.1002\/14651858.CD009219.pub4-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1383-5718(01)00278-9","article-title":"Chemotherapy-induced chromosomal damage in peripheral blood lymphocytes of cancer patients supplemented with antioxidants or placebo","volume":"498","author":"Elsendoorn","year":"2001","journal-title":"Mutation Research"},{"issue":"22","key":"10.1002\/14651858.CD009219.pub4-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1200\/JCO.2007.14.3974","article-title":"Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma","volume":"26","author":"Fouladi","year":"2008","journal-title":"Journal of Clinical Oncology"},{"issue":"5","key":"10.1002\/14651858.CD009219.pub4-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/sj.bjc.6602740","article-title":"Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies","volume":"93","author":"Geoerger","year":"2005","journal-title":"British Journal of Cancer"},{"issue":"2","key":"10.1002\/14651858.CD009219.pub4-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-2125.1996.39114.x","article-title":"Calcium supplementation and ototoxicity in patients receiving cisplatin","volume":"42","author":"Grau","year":"1996","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"6","key":"10.1002\/14651858.CD009219.pub4-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/neuonc\/not241","article-title":"Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma","volume":"16","author":"Gurney","year":"2014","journal-title":"Neuro-Oncology"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2273.1986.tb00144.x","article-title":"Assessment of the effect of chemotherapy and radiotherapy on the auditory function of children with cancer","volume":"11","author":"Kingston","year":"1986","journal-title":"Clinical Otolaryngology and Allied Sciences"},{"issue":"4 Suppl Nurse E","key":"10.1002\/14651858.CD009219.pub4-BIB0012|cit12","first-page":"35","article-title":"Hearing loss in pediatric cancer survivors treated with cisplatin","volume":"22","author":"Knight","year":"2008","journal-title":"Oncology (Williston Park)"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1200\/JCO.2009.27.3524","article-title":"Randomized trial of prophylactic granulocyte colony-stimulating factor during rapid COJEC induction in pediatric patients with high-risk neuroblastoma: the European HR-NBL1\/SIOPEN study","volume":"28","author":"Ladenstein","year":"2010","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0014|cit14","first-page":"26","article-title":"Cis-platinum (CDDP) ototoxicity in pediatric patients","author":"Mahoney","year":"1982","journal-title":"Proceedings of the American Society of Clinical Oncology"},{"issue":"6","key":"10.1002\/14651858.CD009219.pub4-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0022-3476(83)80747-1","article-title":"Ototoxicity with cisplatin therapy","volume":"103","author":"Mahoney","year":"1983","journal-title":"Journal of Pediatrics"},{"issue":"4","key":"10.1002\/14651858.CD009219.pub4-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/cncr.21218","article-title":"Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study","volume":"104","author":"Marina","year":"2005","journal-title":"Cancer"},{"issue":"2","key":"10.1002\/14651858.CD009219.pub4-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0022-3476(83)80551-4","article-title":"Hearing loss in children receiving cisplatin chemotherapy","volume":"102","author":"McHaney","year":"1983","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/b109924_13","article-title":"Auditory late effects of chemotherapy","volume":"150","author":"Meyer","year":"2009","journal-title":"Cancer Treatment and Research"},{"issue":"6","key":"10.1002\/14651858.CD009219.pub4-BIB0019|cit19","first-page":"871","article-title":"Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man","volume":"58","author":"Piel","year":"1974","journal-title":"Cancer Chemotherapy Reports"},{"issue":"2","key":"10.1002\/14651858.CD009219.pub4-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/pbc.20627","article-title":"Preventing platinum-induced ototoxicity in children - is there a potential role for sodium thiosulfate?","volume":"47","author":"Skinner","year":"2006","journal-title":"Pediatric Blood and Cancer"},{"issue":"16","key":"10.1002\/14651858.CD009219.pub4-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1200\/JCO.2006.08.2388","article-title":"Phase I clinical trial of oxaliplatin in children and adolescents with refractory solid tumors","volume":"25","author":"Spunt","year":"2007","journal-title":"Journal of Clinical Oncology"},{"issue":"24","key":"10.1002\/14651858.CD009219.pub4-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1002\/cncr.24668","article-title":"Hepatoblastoma, cisplatin, and ototoxicity: good news on deaf ears","volume":"115","author":"Sullivan","year":"2009","journal-title":"Cancer"},{"issue":"11","key":"10.1002\/14651858.CD009219.pub4-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.ejca.2004.02.029","article-title":"Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study","volume":"40","author":"Weijl","year":"2004","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"abstract 10017","DOI":"10.1200\/jco.2014.32.15_suppl.10017","article-title":"The effects of sodium thiosulfate (STS) on cisplatin-induced hearing loss: a report from the Children's Oncology Group","volume":"5s","author":"Freyer","year":"2014","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0025|cit25","first-page":"abstract TPS100","article-title":"SIOPEL 6: a multicenter open-label randomized phase III trial of the efficacy of sodium thiosulphate (STS) in reducing ototoxicity in patients receiving cisplatin (Cis) monotherapy for standard-risk hepatoblastoma (SR-HB)","volume":"5s","author":"Maibach","year":"2014","journal-title":"Journal of Clinical Oncology"},{"issue":"10","key":"10.1002\/14651858.CD009219.pub4-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/01.mph.0000141348.62532.73","article-title":"Platinum compound-related ototoxicity in children: long-term follow-up reveals continuous worsening of hearing loss","volume":"26","author":"Bertolini","year":"2004","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"4","key":"10.1002\/14651858.CD009219.pub4-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/mpo.2950190415","article-title":"Cisplatin ototoxicity in children: a practical grading system","volume":"19","author":"Brock","year":"1991","journal-title":"Medical and Pediatric Oncology"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0028|cit28","first-page":"123","article-title":"Late effects of cancer treatment and current protective measures","volume-title":"Cancer in Children","author":"Jenney","year":"2005"},{"issue":"2","key":"10.1002\/14651858.CD009219.pub4-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/MPH.0b013e31815d1d83","article-title":"Hearing loss in pediatric oncology patients receiving carboplatin-containing regimens","volume":"30","author":"Dean","year":"2008","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0030|cit30","unstructured":"Eloxatin summary of product characteristics www.sanofi-aventis.co.uk\/products\/Eloxatin_SPC.pdf"},{"issue":"2","key":"10.1002\/14651858.CD009219.pub4-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1200\/JCO.2008.20.1160","article-title":"Prevention of hearing loss in children receiving cisplatin chemotherapy","volume":"27","author":"Freyer","year":"2009","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD009219.pub4-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"744","DOI":"10.7326\/0003-4819-91-5-744","article-title":"Furosemide-induced ototoxicity","volume":"91","author":"Gallagher","year":"1979","journal-title":"Annals of Internal Medicine"},{"issue":"9209","key":"10.1002\/14651858.CD009219.pub4-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0140-6736(00)02044-4","article-title":"Circulating plasma platinum more than 10 years after cisplatin treatment for testicular cancer","volume":"355","author":"Gietema","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0034|cit34","unstructured":"McMaster University GRADEprofiler 3.6.1 2011"},{"issue":"7","key":"10.1002\/14651858.CD009219.pub4-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1542\/pir.25-7-224","article-title":"Pediatric audiology: a review","volume":"25","author":"Gregg","year":"2004","journal-title":"Pediatrics in Review"},{"issue":"4","key":"10.1002\/14651858.CD009219.pub4-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"e938","DOI":"10.1542\/peds.2009-1597","article-title":"Auditory late effects of childhood cancer therapy: a report from the Children's Oncology Group","volume":"125","author":"Grewal","year":"2010","journal-title":"Pediatrics"},{"issue":"5","key":"10.1002\/14651858.CD009219.pub4-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"e1229","DOI":"10.1542\/peds.2007-0178","article-title":"Hearing loss, quality of life, and academic problems in long-term neuroblastoma survivors: a report from the Children's Oncology Group","volume":"120","author":"Gurney","year":"2007","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0038|cit38","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"34","key":"10.1002\/14651858.CD009219.pub4-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1200\/JCO.2004.00.5355","article-title":"Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development","volume":"23","author":"Knight","year":"2005","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0197-2456(00)00046-5","article-title":"Statistical considerations in the intent-to-treat principle","volume":"21","author":"Lachin","year":"2000","journal-title":"Controlled Clinical Trials"},{"issue":"3","key":"10.1002\/14651858.CD009219.pub4-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jpeds.2012.09.012","article-title":"Validation of search filters for identifying pediatric studies in PubMed","volume":"162","author":"Leclercq","year":"2013","journal-title":"Journal of Pediatrics"},{"issue":"16","key":"10.1002\/14651858.CD009219.pub4-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.ejca.2003.08.009","article-title":"Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose","volume":"40","author":"Li","year":"2004","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0043|cit43","unstructured":"Kremer LCM van Dalen EC Moher D Caron HN Cochrane Childhood Cancer Group About the Cochrane Collaboration (Cochrane Review Groups (CRGs) Art. No.: CHILDCA"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0044|cit44","unstructured":"National Cancer Institute Common Toxicity Criteria version 2 ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm"},{"issue":"1","key":"10.1002\/14651858.CD009219.pub4-BIB0045|cit45","first-page":"19","article-title":"Ototoxicity in patients receiving cisplatin: importance of dose and method of drug administration","volume":"66","author":"Reddel","year":"1982","journal-title":"Cancer Treatment Reports"},{"key":"10.1002\/14651858.CD009219.pub4-BIB0046|cit46","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"12","key":"10.1002\/14651858.CD009219.pub4-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ng.478","article-title":"Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy","volume":"41","author":"Ross","year":"2009","journal-title":"Nature Genetics"},{"issue":"1-2","key":"10.1002\/14651858.CD009219.pub4-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.heares.2006.09.015","article-title":"Mechanisms of cisplatin-induced ototoxicity and prevention","volume":"226","author":"Rybak","year":"2007","journal-title":"Hearing Research"},{"issue":"3","key":"10.1002\/14651858.CD009219.pub4-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1620\/tjem.219.177","article-title":"Cisplatin ototoxicity and protection: clinical and experimental studies","volume":"219","author":"Rybak","year":"2009","journal-title":"Tohoku Journal of Experimental Medicine"},{"issue":"6","key":"10.1002\/14651858.CD009219.pub4-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1200\/JCO.1989.7.6.754","article-title":"Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation","volume":"7","author":"Schell","year":"1989","journal-title":"Journal of Clinical Oncology"},{"issue":"16","key":"10.1002\/14651858.CD009219.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/j.ejca.2004.08.002","article-title":"Best practice in assessing ototoxicity in children with cancer","volume":"40","author":"Skinner","year":"2004","journal-title":"European Journal of Cancer"},{"issue":"6","key":"10.1002\/14651858.CD009219.pub4-BIB0052|cit52","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010885.pub2","article-title":"Different infusion durations for preventing platinum-induced hearing loss in children with cancer","author":"As","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD009219.pub4-BIB0053|cit53","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010181.pub2","article-title":"Platinum-induced hearing loss after treatment for childhood cancer","author":"As","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD009219.pub4-BIB0054|cit54","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010885.pub3","article-title":"Different infusion durations for preventing platinum-induced hearing loss in children with cancer","author":"As","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD009219.pub4-BIB0055|cit55","first-page":"2205","article-title":"Influence of cellular factors and pharmacokinetics on the formation of platinum-DNA adducts in leukocytes of children receiving cisplatin therapy","volume":"7","author":"Veal","year":"2001","journal-title":"Clinical Cancer Research"},{"issue":"7","key":"10.1002\/14651858.CD009219.pub4-BIB0056|cit56","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009219","article-title":"Medical interventions for the prevention of platinum-induced hearing loss in children with cancer","author":"As","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD009219.pub4-BIB0057|cit57","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009219.pub2","article-title":"Medical interventions for the prevention of platinum-induced hearing loss in children with cancer","author":"As","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"10.1002\/14651858.CD009219.pub4-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009219.pub3","article-title":"Medical interventions for the prevention of platinum-induced hearing loss in children with cancer","author":"As","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd009219.pub5","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD009219.pub4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T22:29:38Z","timestamp":1628548178000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD009219.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Childhood Cancer Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,27]]},"references-count":58,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd009219.pub4","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD009219.pub5","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,27]]}}}