{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:12:46Z","timestamp":1787613166415,"version":"build-2736575974"},"update-to":[{"DOI":"10.1002\/14651858.cd009420.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000}}],"reference-count":37,"publisher":"Wiley","issue":"5","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd009420.pub3","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T20:58:38Z","timestamp":1446497918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Levomepromazine for nausea and vomiting in palliative care"],"prefix":"10.1002","volume":"2017","author":[{"given":"Lalage","family":"Cox","sequence":"first","affiliation":[{"name":"St Peter's Hospice; Brentry Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Darvill","sequence":"additional","affiliation":[{"name":"Cheltenham General Hospital; General Medicine; Sandford Road Cheltenham UK GL53 7AN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskie","family":"Dorman","sequence":"additional","affiliation":[{"name":"Poole Hospital NHS Foundation Trust; Palliative Medicine; Longfleet Road Poole UK BH15 2JB"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"issue":"2","key":"10.1002\/14651858.CD009420.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/082585970402000209","article-title":"High-dose levomepromazine (methotrimeprazine) to control nausea in carcinoid syndrome","volume":"20","author":"Amesbury","year":"2004","journal-title":"Journal of Palliative Care"},{"issue":"8462","key":"10.1002\/14651858.CD009420.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S0140-6736(85)90534-3","article-title":"Medical management of intestinal obstruction in patients with advanced malignant disease","volume":"2","author":"Baines","year":"1985","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD009420.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s00482-012-1216-7","article-title":"Treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients: a review","volume":"26","author":"Benze","year":"2012","journal-title":"Der Schmerz"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0004|cit4","doi-asserted-by":"crossref","DOI":"10.1186\/1472-684X-12-2","article-title":"Evidence for the use of levomepromazine for symptom control in the palliative care setting: a systematic review","volume":"12","author":"Dietz","year":"2013","journal-title":"BMC Palliative Care"},{"issue":"1","key":"10.1002\/14651858.CD009420.pub3-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1191\/0269216305pm972oa","article-title":"Low-dose levomepromazine in refractory emesis in advanced cancer patients: an open-label study","volume":"19","author":"Eisenchlas","year":"2005","journal-title":"Palliative Medicine"},{"issue":"35","key":"10.1002\/14651858.CD009420.pub3-BIB0006|cit6","first-page":"945","article-title":"Prevention of cytostatic-induced vomiting. High-dosage metoclopramide versus an antiemetic combination in a controlled comparison","volume":"34","author":"Ell","year":"1983","journal-title":"Die Medizinische Welt"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejphar.2013.10.010","article-title":"Nausea and vomiting in advanced cancer","volume":"722","author":"Gordon","year":"2014","journal-title":"European Journal of Pharmacology"},{"issue":"22","key":"10.1002\/14651858.CD009420.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1055\/s-2008-1070754","article-title":"Improved antiemetic treatment with levomepromazine","volume":"105","author":"Higi","year":"1980","journal-title":"Deutsche Medizinische Wochenschrift"},{"issue":"9","key":"10.1002\/14651858.CD009420.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00520-004-0768-1","article-title":"An open study of methotrimeprazine in the management of nausea and vomiting in patients with advanced cancer","volume":"13","author":"Kennett","year":"2005","journal-title":"Supportive Care in Cancer"},{"issue":"6D","key":"10.1002\/14651858.CD009420.pub3-BIB0010|cit10","first-page":"5209","article-title":"Subcutaneous levomepromazine rescue (SLR) for high grade delayed chemotherapy-induced emesis (DCIE)","volume":"23","author":"McCabe","year":"2003","journal-title":"Anticancer Research"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0011|cit11","first-page":"S68","article-title":"Levomepromazine versus dexamethasone with metoclopramide in the prevention of cisplatin induced delayed emesis. Preliminary results of a randomised study","volume":"88","author":"Sgouros","year":"2003","journal-title":"British Journal of Cancer"},{"issue":"2","key":"10.1002\/14651858.CD009420.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/09699260.1997.12098230","article-title":"The use of low dose levomepromazine (methotrimeprazine) in the management of nausea and vomiting","volume":"5","author":"Twycross","year":"1997","journal-title":"Progress in Palliative Care"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0013|cit13","unstructured":"Hardy J A study for participants with cancer who experience ongoing nausea, not related to their treatment, despite taking standard and usual medications, that studies the effectiveness of oral methotrimeprazine versus oral haloperidol https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?ACTRN=12615000177550"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0014|cit14","unstructured":"Hardy J Yates P ACTRN12610000482066 The Australian New Zealand Clinical Trials Registry (ANZCTR) 2010"},{"issue":"3","key":"10.1002\/14651858.CD009420.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1191\/026921601678576239","article-title":"Use of clinical pictures in the management of nausea and vomiting: a prospective audit","volume":"15","author":"Bentley","year":"2001","journal-title":"Palliative Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009420.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00607681","article-title":"Pharmacokinetics and relative bioavailability of levomepromazine after repeated administration of tablets and syrup","volume":"11","author":"Dahl","year":"1977","journal-title":"European Journal of Clincal Pharmacology"},{"issue":"4","key":"10.1002\/14651858.CD009420.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jpainsymman.2009.08.010","article-title":"A systematic review of the treatment of nausea and\/or vomiting in cancer unrelated to chemotherapy or radiation","volume":"39","author":"Davis","year":"2010","journal-title":"Journal of Pain and Symptom Management"},{"issue":"2","key":"10.1002\/14651858.CD009420.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/0269216308100247","article-title":"Symptom management for the adult patient dying with advanced kidney disease: a review of the literature and development of evidence-based guidelines by a United Kingdom Expert Consensus Group","volume":"23","author":"Douglas","year":"2009","journal-title":"Palliative Medicine"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0019|cit19","unstructured":"European Association for Palliative Care Definition of palliative care (English) http:\/\/www.eapcnet.eu\/Corporate\/AbouttheEAPC\/Definitionandaims.aspx"},{"issue":"4","key":"10.1002\/14651858.CD009420.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1191\/026921601678320278","article-title":"A comparison of the palliative care needs of patients dying from chronic respiratory diseases and lung cancer","volume":"15","author":"Edmonds","year":"2001","journal-title":"Palliative Medicine"},{"issue":"6","key":"10.1002\/14651858.CD009420.pub3-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s00520-004-0629-y","article-title":"Systematic review of the efficacy of antiemetics in the treatment of nausea in patients with far-advanced cancer","volume":"12","author":"Glare","year":"2004","journal-title":"Supportive Care in Cancer"},{"issue":"1","key":"10.1002\/14651858.CD009420.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1191\/026921600677940614","article-title":"Why are trials in palliative care so difficult?","volume":"14","author":"Grande","year":"2000","journal-title":"Palliative Medicine"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0023|cit23","unstructured":"Higgins JPT Altman DG Sterne JAC Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"4","key":"10.1002\/14651858.CD009420.pub3-BIB0024|cit24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003346","article-title":"Benzodiazepines and related drugs for insomnia in palliative care","author":"Hirst","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD009420.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0026|cit26","first-page":"2406","article-title":"Nausea and vomiting in people with cancer and other chronic diseases","volume":"2009","author":"Keeley","year":"2009","journal-title":"BMJ Clinical Evidence"},{"issue":"1","key":"10.1002\/14651858.CD009420.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jpainsymman.2003.05.008","article-title":"Symptom burden in the last week of life","volume":"27","author":"Klinkenberg","year":"2004","journal-title":"Journal of Pain and Symptom Management"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0028|cit28","first-page":"15","article-title":"Managing potential publication bias","volume-title":"Systematic Reviews in Pain Research: Methodology Refined","author":"Moore","year":"2008"},{"issue":"2","key":"10.1002\/14651858.CD009420.pub3-BIB0029|cit29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006271.pub2","article-title":"Haloperidol for the treatment of nausea and vomiting in palliative care patients","author":"Perkins","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0030|cit30","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"8","key":"10.1002\/14651858.CD009420.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"568","DOI":"10.12968\/hosp.1999.60.8.1176","article-title":"Levomepromazine for nausea and vomiting in advanced cancer","volume":"60","author":"Skinner","year":"1999","journal-title":"Hospital Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009420.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00520-005-0897-1","article-title":"An assessment of aetiology-based guidelines for the management of nausea and vomiting in patients with advanced cancer","volume":"14","author":"Stephenson","year":"2006","journal-title":"Supportive Care in Cancer"},{"issue":"11","key":"10.1002\/14651858.CD009420.pub3-BIB0033|cit33","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006938.pub3","article-title":"Droperidol for treatment of nausea and vomiting in palliative care patients","author":"Storrar","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0034|cit34","first-page":"39","article-title":"Nausea and vomiting in advanced cancer","volume":"5","author":"Twycross","year":"1998","journal-title":"European Journal of Palliative Care"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0035|cit35","volume-title":"Palliative Care Formulary","author":"Twycross","year":"2014"},{"key":"10.1002\/14651858.CD009420.pub3-BIB0036|cit36","doi-asserted-by":"crossref","DOI":"10.1186\/1472-684X-7-13","article-title":"How useful are systematic reviews for informing palliative care practice? Survey of 25 Cochrane systematic reviews","volume":"7","author":"Wee","year":"2008","journal-title":"BMC Palliative Care"},{"issue":"4","key":"10.1002\/14651858.CD009420.pub3-BIB0037|cit37","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009420.pub2","article-title":"Levomepromazine for nausea and vomiting in palliative care","author":"Darvill","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD009420.pub3\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T06:36:04Z","timestamp":1693377364000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD009420.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Pain, Palliative and Supportive Care Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,2]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd009420.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,2]]}}}