{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:05:50Z","timestamp":1773975950939,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd009498.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000}}],"reference-count":60,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd009498.pub3","type":"journal-article","created":{"date-parts":[[2013,4,28]],"date-time":"2013-04-28T03:25:32Z","timestamp":1367119532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transarterial (chemo)embolisation versus no intervention or placebo intervention for liver metastases"],"prefix":"10.1002","author":[{"given":"Robert P","family":"Riemsma","sequence":"first","affiliation":[{"name":"Kleijnen Systematic Reviews Ltd; Unit 6, Escrick Business Park Riccall Road, Escrick York UK YO19 6FD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata M","family":"Bala","sequence":"additional","affiliation":[{"name":"Jagiellonian University Medical College; 2nd Department of Internal Medicine; 8 Skawinska St Krakow Poland 31-066"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Wolff","sequence":"additional","affiliation":[{"name":"Kleijnen Systematic Reviews Ltd; Unit 6, Escrick Business Park Riccall Road, Escrick York UK YO19 6FD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos","family":"Kleijnen","sequence":"additional","affiliation":[{"name":"School for Public Health and Primary Care (CAPHRI), Maastricht University; Maastricht Netherlands 6200 MD"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"issue":"7","key":"10.1002\/14651858.CD009498.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/bjs.1800770720","article-title":"Prospective randomized controlled trial of hepatic arterial embolisation or infusion chemotherapy with 5-fluorouracil and degradable starch microspheres for colorectal liver metastases","volume":"77","author":"Hunt","year":"1990","journal-title":"British Journal of Surgery"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0002|cit2","unstructured":"Australian Safety Efficacy Register of New Interventional Procedures - Surgical (ASERNIP-S) Radiofrequency ablation of liver tumours (update): A systematic review ASERNIP-S Report No. 56. Adelaide, South Australia: ASERNIP-S (http:\/\/www.surgeons.org\/media\/17297\/RFAupdate.pdf)"},{"issue":"6","key":"10.1002\/14651858.CD009498.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/archsurg.135.6.657","article-title":"Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms: A proposed algorithm","volume":"135","author":"Bilchik","year":"2000","journal-title":"Archives of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD009498.pub3-BIB0004|cit4","first-page":"5","article-title":"Evidence-based guideline on management of colorectal liver metastases in the Netherlands","volume":"65","author":"Bipat","year":"2007","journal-title":"Netherlands Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD009498.pub3-BIB0005|cit5","first-page":"969","article-title":"The blood supply of neoplasms in the liver","volume":"30","author":"Breedis","year":"1954","journal-title":"American Journal of Pathology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jclinepi.2007.10.007","article-title":"Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses","volume":"61","author":"Brok","year":"2008","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/ije\/dyn188","article-title":"Apparently conclusive meta-analyses may be inconclusive - trial sequential analysis adjustment for random error risk in conclusive neonatal meta-analyses","volume":"38","author":"Brok","year":"2009","journal-title":"International Journal of Epidemiology"},{"issue":"20","key":"10.1002\/14651858.CD009498.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1001\/jama.291.20.2457","article-title":"Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles","volume":"291","author":"Chan","year":"2004","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0009|cit9","unstructured":"Copenhagen Trial Unit TSA - Trial Sequential Analysis http:\/\/ctu.dk\/tsa\/"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S1470-2045(04)01567-0","article-title":"Radiofrequency ablation of liver tumours: systematic review","volume":"5","author":"Decadt","year":"2004","journal-title":"Lancet Oncology"},{"issue":"3","key":"10.1002\/14651858.CD009498.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"issue":"7109","key":"10.1002\/14651858.CD009498.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ (Clinical Research Ed.)"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0013|cit13","unstructured":"U.S. Food Drug Administration FDA approvals and investigational device exemptions http:\/\/www.fda.gov\/"},{"issue":"2","key":"10.1002\/14651858.CD009498.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2168.1999.01038.x","article-title":"Treatment of colorectal metastases","volume":"86","author":"Geoghegan","year":"1999","journal-title":"British Journal of Surgery"},{"issue":"3","key":"10.1002\/14651858.CD009498.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.7326\/0003-4819-149-3-200808050-00023","article-title":"Correction: reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses","volume":"149","author":"Gluud","year":"2008","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0016|cit16","unstructured":"Gluud C Nikolova D Klingenberg SL Alexakis N Als-Nielsen B Colli A Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)) 2013, Issue 2. Art. No.: LIVER"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2307\/2530643","article-title":"Estimation of a common effect parameter from sparse follow-up data","volume":"41","author":"Greenland","year":"1985","journal-title":"Biometrics"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0018|cit18","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] The Cochrane Colloboration, 2011. Available from www.cochrane-handbook.org"},{"issue":"7","key":"10.1002\/14651858.CD009498.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1445-2197.1997.tb02003.x","article-title":"The aetiology and management of hepatic metastases","volume":"67","author":"Hugh","year":"1997","journal-title":"The Australian and New Zealand Journal of Surgery"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0020|cit20","unstructured":"International Agency for Research on Cancer Cancer Incidence and Mortality Worldwide in 2008 http:\/\/globocan.iarc.fr\/"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0021|cit21","volume-title":"International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonised tripartite guideline. Guideline for good clinical practice1997 CFR & ICH Guidelines","volume":"1","author":"International Conference on Harmonisation Expert Working Group","year":"1997"},{"issue":"6","key":"10.1002\/14651858.CD009498.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/BF02577625","article-title":"Seguential transarterial chemoembolization for unresectable advanced hepatocellular carcinoma","volume":"19","author":"Jaeger","year":"1996","journal-title":"Cardiovascular and Interventional Radiology"},{"issue":"5","key":"10.1002\/14651858.CD009498.pub3-BIB0023|cit23","first-page":"277","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7326\/0003-4819-135-11-200112040-00010","article-title":"Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses","volume":"135","author":"Kjaergard","year":"2001","journal-title":"Annals of Internal Medicine"},{"issue":"2","key":"10.1002\/14651858.CD009498.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/1098-2388(200009)19:2<135::AID-SSU6>3.0.CO;2-A","article-title":"Primary liver tumors","volume":"19","author":"Lau","year":"2000","journal-title":"Seminars in Surgical Oncology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1053\/jhep.2003.50047","article-title":"Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival","volume":"37","author":"Llovet","year":"2003","journal-title":"Hepatology"},{"issue":"11","key":"10.1002\/14651858.CD009498.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/j.1365-2036.2006.02932.x","article-title":"Systematic review: evidence-based management of hepatocellular carcinoma - an updated analysis of randomized controlled trials","volume":"23","author":"Lopez","year":"2006","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"12","key":"10.1002\/14651858.CD009498.pub3-BIB0028|cit28","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.MR000033.pub2","article-title":"Industry sponsorship and research outcome","author":"Lundh","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0029|cit29","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0168-8278(98)80162-1","article-title":"Treatment options in Western hepatocellular carcinoma: a prospective study of 224 patients","volume":"29","author":"Markovic","year":"1998","journal-title":"Journal of Hepatology"},{"issue":"2","key":"10.1002\/14651858.CD009498.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/1098-2388(200009)19:2<177::AID-SSU9>3.0.CO;2-S","article-title":"Metastatic liver tumours","volume":"19","author":"McCarter","year":"2000","journal-title":"Seminars in Surgical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD009498.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/107327480601300105","article-title":"Resection of colorectal liver metastases: current perspectives","volume":"13","author":"McLoughlin","year":"2006","journal-title":"Cancer Control"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S0168-8278(97)80462-X","article-title":"Liver resection or transplantation for hepatocellular carcinoma?","volume":"26","author":"Michel","year":"2002","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(98)01085-X","article-title":"Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?","volume":"352","author":"Moher","year":"1998","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0035|cit35","unstructured":"National Cancer Institute SEER Cancer Statistics Review, 1975-2007 http:\/\/seer.cancer.gov\/csr\/1975_2007\/"},{"issue":"3","key":"10.1002\/14651858.CD009498.pub3-BIB0036|cit36","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004787.pub2","article-title":"Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma","author":"Oliveri","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD009498.pub3-BIB0037|cit37","first-page":"74-108","article-title":"Global Cancer Statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8","article-title":"Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints","volume":"17","author":"Parmar","year":"1998","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0039|cit39","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2012"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0040|cit40","unstructured":"Riemsma R Bala M Wolff R Kleijnen J Non-surgical ablation methods for primary malignant liver tumours and liver metastases Website of the Dutch Health Care Insurance Board (http:\/\/www.cvz.nl\/binaries\/live\/cvzinternet\/hst_content\/nl\/documenten\/standpunten\/2009\/sp0905+interventies+levertumoren.pdf) 31 302"},{"issue":"4","key":"10.1002\/14651858.CD009498.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1017\/S0266462303000552","article-title":"Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches","volume":"19","author":"Royle","year":"2003","journal-title":"International Journal of Technology Assessment in Health Care"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"429","DOI":"10.7326\/0003-4819-157-6-201209180-00537","article-title":"Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials","volume":"157","author":"Savovi\u0107","year":"2012","journal-title":"Annals of Internal Medicine"},{"issue":"35","key":"10.1002\/14651858.CD009498.pub3-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta16350","article-title":"Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials","volume":"16","author":"Savovi\u0107","year":"2012","journal-title":"Health Technology Assessment"},{"issue":"5","key":"10.1002\/14651858.CD009498.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.cad.0000131140.12228.bb","article-title":"Therapy for unresectable hepatocellular carcinoma: review of the randomized clinical trials-II: systemic and local non-embolization-based therapies in unresectable and advanced hepatocellular carcinoma","volume":"15","author":"Schwartz","year":"2004","journal-title":"Anti-Cancer Drugs"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/archsurg.141.2.181","article-title":"Radiofrequency ablation of liver tumors. A systematic review","volume":"141","author":"Sutherland","year":"2006","journal-title":"Archives of Surgery"},{"issue":"6","key":"10.1002\/14651858.CD009498.pub3-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/bjc.1978.283","article-title":"The blood supply of colorectal liver metastases","volume":"38","author":"Taylor","year":"1978","journal-title":"British Journal of Cancer"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/ije\/dyn179","article-title":"Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?","volume":"38","author":"Thorlund","year":"2009","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0049|cit49","first-page":"57","article-title":"Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals","volume":"2","author":"Thorlund","year":"2010","journal-title":"Clinical Epidemiology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0050|cit50","unstructured":"Thorlund K Engstr\u00f8m J Wetterslev J Brok J Imberger G Gluud C User manual forTrial Sequential Analysis (TSA) http:\/\/ctu.dk\/tsa\/files\/tsa_manual.pdf 1 115"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1745-6215-8-16","article-title":"Practical methods for incorporating summary time-to-event data into meta-analysis","volume":"8","author":"Tierney","year":"2007","journal-title":"Trials"},{"issue":"2","key":"10.1002\/14651858.CD009498.pub3-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1148\/radiol.2292021329","article-title":"Liver metastases: neoadjuvant downsizing with transarterial chemoembolization before laser-induced thermotherapy","volume":"229","author":"Vogl","year":"2003","journal-title":"Radiology"},{"issue":"4","key":"10.1002\/14651858.CD009498.pub3-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00330-006-0372-5","article-title":"Colorectal liver metastases: regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion - an update","volume":"17","author":"Vogl","year":"2007","journal-title":"European Radiology"},{"issue":"1","key":"10.1002\/14651858.CD009498.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1148\/radiol.2501080295","article-title":"Repeated transarterial chemoembolization in the treatment of liver metastases of colorectal cancer: prospective study","volume":"250","author":"Vogl","year":"2009","journal-title":"Radiology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/path.1711500308","article-title":"Hematogenous metastatic patterns in colonic carcinoma: an analysis of 1441 necropsies","volume":"140","author":"Weiss","year":"1986","journal-title":"Journal of Pathology"},{"issue":"1","key":"10.1002\/14651858.CD009498.pub3-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jclinepi.2007.03.013","article-title":"Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis","volume":"61","author":"Wetterslev","year":"2008","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2288-9-86","article-title":"Estimating required information size by quantifying diversity in a random-effects meta-analysis","volume":"9","author":"Wetterslev","year":"2009","journal-title":"BMC Medical Research Methodology"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0058|cit58","unstructured":"World Health Organization International Clinical Trials Registry Platform (ICTRP) http:\/\/www.who.int\/ictrp\/en\/"},{"key":"10.1002\/14651858.CD009498.pub3-BIB0059|cit59","first-page":"285","article-title":"A retrospective study of patients with liver metastases from colorectal cancer","volume":"2","author":"Wood","year":"1976","journal-title":"Clinical Oncology"},{"issue":"7644","key":"10.1002\/14651858.CD009498.pub3-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/bmj.39465.451748.AD","article-title":"Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study","volume":"336","author":"Wood","year":"2008","journal-title":"BMJ (Clinical Research Ed.)"}],"updated-by":[{"DOI":"10.1002\/14651858.cd009498.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD009498.pub3\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T22:33:26Z","timestamp":1628548406000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD009498.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Hepato-Biliary Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,30]]},"references-count":60,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd009498.pub3","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD009498.pub4","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,30]]}}}