{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:51:35Z","timestamp":1780494695160,"version":"3.54.1"},"reference-count":566,"publisher":"Wiley","issue":"6","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd009925","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T15:11:22Z","timestamp":1339168282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Second trimester serum tests for Down's Syndrome screening"],"prefix":"10.1002","volume":"2012","author":[{"given":"S Kate","family":"Alldred","sequence":"first","affiliation":[{"name":"The University of Liverpool; Department of Women's and Children's Health; First Floor, Liverpool Women's NHS Foundation Trust Crown Street Liverpool UK L8 7SS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J","family":"Deeks","sequence":"additional","affiliation":[{"name":"University of Birmingham; Public Health, Epidemiology and Biostatistics; Edgbaston Birmingham UK B15 2TT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boliang","family":"Guo","sequence":"additional","affiliation":[{"name":"University of Nottingham; School of Community Health Science; Nottingham East Midlands UK NG7 2GT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Neilson","sequence":"additional","affiliation":[{"name":"The University of Liverpool; Department of Women's and Children's Health; First Floor, Liverpool Women's NHS Foundation Trust Crown Street Liverpool UK L8 7SS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarko","family":"Alfirevic","sequence":"additional","affiliation":[{"name":"The University of Liverpool; Department of Women's and Children's Health; First Floor, Liverpool Women's NHS Foundation Trust Crown Street Liverpool UK L8 7SS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1515\/JPM.1999.024","article-title":"The sensitivity of the trivariate analysis using maternal serum alpha-feto protein, human chorionic gonadotrophin and maternal age in screening for fetal aneuploidy in mothers above the age of 35","volume":"27","author":"Anandakumar","year":"1999","journal-title":"Journal of Perinatal Medicine"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1469-0705.2001.00457.x","article-title":"Screening for Down syndrome using first-trimester ultrasound and second-trimester maternal serum markers in a low-risk population: a prospective longitudinal study","volume":"18","author":"Audibert","year":"2001","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0002-9378(99)70327-3","article-title":"Elevated maternal urine level of \u00df-core fragment of human chorionic gonadotropin versus serum triple test in the second-trimester detection of Down syndrome","volume":"181","author":"Bahado","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1469-0705.2000.00071.x","article-title":"Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation","volume":"15","author":"Bahado","year":"2000","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"issue":"6 I","key":"10.1002\/14651858.CD009925-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0002-9378(98)70036-5","article-title":"New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age","volume":"179","author":"Bahado-Singh","year":"1998","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajmg.1320370220","article-title":"Maternal serum hCG and SP1 in pregnancies with fetal aneuploidy","volume":"37","author":"Bartels","year":"1990","journal-title":"American Journal of Medical Genetics"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/pd.1970090602","article-title":"Human chorionic gonadotropin levels in pregnancies with aneuploid fetuses","volume":"9","author":"Bogart","year":"1989","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/pd.1970070904","article-title":"Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities","volume":"7","author":"Bogart","year":"1987","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02391798","article-title":"Risk of fetal Down's syndrome based on maternal age and varying combinations of maternal serum markers","volume":"255","author":"Bartels","year":"1994","journal-title":"Archives of Gynecology & Obstetrics"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02391798","article-title":"Risk of fetal Down's syndrome based on maternal age and varying combinations of maternal serum markers","volume":"255","author":"Bartels","year":"1994","journal-title":"Archives of Gynecology & Obstetrics"},{"issue":"26","key":"10.1002\/14651858.CD009925-BIB0011|cit11","first-page":"1303","article-title":"[Serum screening of pregnant women for fetal neural tube defects and Down syndrome; initial experiences in The Netherlands]. [Dutch]","volume":"137","author":"Beekhuis","year":"1993","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000020900","article-title":"Efficiency of ultrasound and biochemical markers for Down's syndrome risk screening. A prospective study","volume":"14","author":"Benattar","year":"1999","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000020871","article-title":"Screening for Down's syndrome and neural tube defect in Croatia. A regional prospective study","volume":"13","author":"Brajenovic","year":"1998","journal-title":"Fetal Diagnosis and Therapy"},{"issue":"3 Suppl","key":"10.1002\/14651858.CD009925-BIB0014|cit14","first-page":"85","article-title":"Evaluation of maternal serum alpha-fetoprotein and ultrasound examination to screen fetal chromosomal abnormalities","volume":"33","author":"Brizzi","year":"1989","journal-title":"Journal of Nuclear Medicine & Allied Sciences"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1034\/j.1600-0412.1999.780509.x","article-title":"Second trimester maternal serum screening using alpha fetoprotein, free \u00df human chorionic gonadotropin and maternal age specific risk: result of chromosomal abnormalities detected in screen positive for Down syndrome in an Asian population","volume":"78","author":"Chao","year":"1999","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/(SICI)1097-0223(199910)19:10<905::AID-PD658>3.0.CO;2-Q","article-title":"The proform of eosinophil major basic protein: a new maternal serum marker for Down syndrome","volume":"19","author":"Christiansen","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j..2004.00177.x","article-title":"Screening for Down's syndrome in early and late first and second trimester using six maternal serum markers","volume":"65","author":"Christiansen","year":"2004","journal-title":"Clinical Genetics"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0923-2532(00)80005-8","article-title":"Screening of maternal serum for prenatal Down's syndrome and neural tube defects: An Italian experience","volume":"15","author":"Cioffi","year":"2000","journal-title":"Immuno-Analyse et Biologie Specialisee"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/096914139400100309","article-title":"Impact of a regional screening programme using maternal serum alpha fetoprotein (AFP) and human chorionic gonadotrophin (hCG) on the birth incidence of Down's syndrome in the west of Scotland","volume":"1","author":"Crossley","year":"1994","journal-title":"Journal of Medical Screening"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000264287","article-title":"Unconjugated estriol as maternal serum marker for the detection of Down syndrome pregnancies","volume":"11","author":"David","year":"1996","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000010263","article-title":"Multiple screening for fetal Down's syndrome with the classic triple test, dimeric Inhibin A and ultrasound","volume":"49","author":"Debieve","year":"2000","journal-title":"Gynecologic & Obstetric Investigation"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/humrep\/13.1.220","article-title":"Second-trimester maternal serum screening for Down's syndrome: free \u00df-human chorionic gonadotrophin (HCG) and alpha-fetoprotein, with or without unconjugated oestriol, compared with total HCG, alpha-fetoprotein and unconjugated oestriol","volume":"13","author":"Extermann","year":"1998","journal-title":"Human Reproduction"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0009-9120(95)00021-Z","article-title":"Screening for Down syndrome during the first and second trimesters: impact of risk estimation parameters","volume":"28","author":"Forest","year":"1995","journal-title":"Clinical Biochemistry"},{"issue":"5 Pt 1","key":"10.1002\/14651858.CD009925-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0002-9378(91)90375-2","article-title":"The effect of gestational age on the detection rate of Down's syndrome by maternal serum alpha-fetoprotein screening","volume":"165","author":"Greenberg","year":"1991","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"16","key":"10.1002\/14651858.CD009925-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1056\/NEJM199404213301603","article-title":"Reducing the need for amniocentesis in women 35 years of age or older with serum markers for screening","volume":"330","author":"Haddow","year":"1994","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/jms.5.3.115","article-title":"Second trimester screening for Down's syndrome using maternal serum dimeric Inhibin A","volume":"5","author":"Haddow","year":"1998","journal-title":"Journal of Medical Screening"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0027|cit27","first-page":"1025","article-title":"Maternal serum screening for aneuploid pregnancy by alpha-fetoprotein, hCG, and unconjugated estriol","volume":"76","author":"Heyl","year":"1990","journal-title":"Obstetrics & Gynecology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/(SICI)1097-0223(199708)17:8<707::AID-PD142>3.0.CO;2-H","article-title":"Comparison of Down's syndrome screening strategies in Asians combining serum free \u00df-hCG and alpha-fetoprotein with maternal age","volume":"17","author":"Hsu","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0301-2115(99)00121-9","article-title":"The triple-marker test in predicting fetal aneuploidy: a compromise between sensitivity and specificity","volume":"88","author":"Huderer-Duric","year":"2000","journal-title":"European Journal of Obstetrics, Gynecology, & Reproductive Biology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000020986","article-title":"Maternal serum screening for down syndrome by using alpha-fetoprotein and human chorionic gonadotropin in an asian population. a prospective study","volume":"15","author":"Jou","year":"2000","journal-title":"Fetal Diagnosis & Therapy.15(2):108-11,"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1046\/j.1469-0705.1997.09040244.x","article-title":"The effect of nuchal translucency measurement on second-trimester biochemical screening for Down's syndrome","volume":"9","author":"Kadir","year":"1997","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/01443619964670","article-title":"Second trimester maternal serum biochemical screening for Down's syndrome: Experience of a single obstetric unit","volume":"19","author":"Kadir","year":"1999","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000020987","article-title":"Efficacy of maternal serum screening in the prenatal detection of fetal chromosome abnormalities in Japanese women","volume":"15","author":"Kishida","year":"2000","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1097-0223(199803)18:3<235::AID-PD248>3.0.CO;2-A","article-title":"hCG and the free \u00df-subunit as screening tests for Down syndrome","volume":"18","author":"Knight","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/pd.382","article-title":"Comparison and integration of first trimester fetal nuchal translucency and second trimester maternal serum screening for fetal Down syndrome","volume":"22","author":"Lam","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0009-8981(95)06084-Q","article-title":"Maternal serum screening for fetal Down's syndrome, a retrospective study","volume":"238","author":"Lemay","year":"1995","journal-title":"Clinica Chimica Acta"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1097\/01.AOG.0000241095.19638.f2","article-title":"Comparison of serum markers in first-trimester down syndrome screening","volume":"108","author":"Canick","year":"2006","journal-title":"Obstetrics & Gynecology"},{"issue":"19","key":"10.1002\/14651858.CD009925-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1056\/NEJMoa043693","article-title":"First-trimester or second-trimester screening, or both, for Down's syndrome","volume":"353","author":"Malone","year":"2005","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/pd.1970110406","article-title":"Screening for fetal Down's syndrome with maternal serum markers--an experience in Italy","volume":"11","author":"Mancini","year":"1991","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000263830","article-title":"Maternal serum screening for chromosome defects: human chorionic gonadotropin versus its free-\u00df subunit","volume":"8","author":"Milunsky","year":"1993","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/pd.1970130106","article-title":"Prospective maternal serum human chorionic gonadotropin screening for the risk of fetal chromosome anomalies and of subsequent fetal and neonatal deaths","volume":"13","author":"Muller","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/pd.1970100606","article-title":"A single chorionic gonadotropin assay for maternal serum screening for Down's syndrome","volume":"10","author":"Muller","year":"1990","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0028-2243(95)02293-2","article-title":"Maternal serum markers for fetal trisomy 21 screening. [Review]","volume":"65","author":"Muller","year":"1996","journal-title":"European Journal of Obstetrics, Gynecology, & Reproductive Biology"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1373\/clinchem.2004.038059","article-title":"Maternal serum invasive trophoblast antigen (hyperglycosylated hCG) as a screening marker for Down syndrome during the second trimester","volume":"50","author":"Palomaki","year":"2004","journal-title":"Clinical Chemistry"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/pd.1497","article-title":"Repeated measurement of pregnancy-associated plasma protein-A (PAPP-A) in Down syndrome screening: a validation study","volume":"26","author":"Palomaki","year":"2006","journal-title":"Prenatal Diagnosis"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1373\/clinchem.2004.032839","article-title":"Second-trimester maternal serum invasive trophoblast antigen: a marker for Down syndrome screening","volume":"50","author":"Pandian","year":"2004","journal-title":"Clinical Chemistry"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02592410","article-title":"Maternal serum markers. Estimation of the risk of Down's syndrome: a prospective study","volume":"24","author":"Mancini","year":"1994","journal-title":"International Journal of Clinical & Laboratory Research"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s005990050007","article-title":"Repeat testing of mothers with high human chorionic gonadotrophin levels in Down's syndrome screening","volume":"27","author":"Perona","year":"1997","journal-title":"International Journal of Clinical & Laboratory Research"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/096914139400100109","article-title":"Implementation of an antenatal serum screening programme for Down's syndrome in two districts (Brighton and Eastbourne). The Brighton and Eastbourne Down's Syndrome Screening Group","volume":"1","author":"Piggott","year":"1994","journal-title":"Journal of Medical Screening"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<101::AID-PD4>3.0.CO;2-H","article-title":"Schwangerschaftsprotein 1 (SP1) as a maternal serum marker for Down syndrome in the first and second trimesters","volume":"17","author":"Qin","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/(SICI)1097-0223(200001)20:1<17::AID-PD744>3.0.CO;2-Y","article-title":"Prenatal detection of trisomy 21: combined experience of two British hospitals","volume":"20","author":"Roberts","year":"2000","journal-title":"Prenatal Diagnosis."},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0002-9378(94)70100-8","article-title":"Maternal serum alpha-fetoprotein screening for chromosomal abnormalities: A prospective study in women aged 35 and older","volume":"170","author":"Rose","year":"1994","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/pd.238","article-title":"A negative second trimester triple test and absence of specific ultrasonographic markers may decrease the need for genetic amniocentesis in advanced maternal age by 60%","volume":"22","author":"Rosen","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/humrep\/17.4.1093","article-title":"Down's syndrome screening with nuchal translucency at 12(+0)-14(+0) weeks and maternal serum markers at 14(+1)-17(+0) weeks: a prospective study","volume":"17","author":"Rozenberg","year":"2002","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000068073","article-title":"Comparison of triple-risk assessment of fetal trisomy 21 including total human choriogonadotropin (hCG) or its free \u00df-subunit (free \u00df hCG)","volume":"18","author":"Sancken","year":"2003","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pd.218","article-title":"Raised maternal serum placenta growth factor concentration during the second trimester is associated with Down syndrome","volume":"22","author":"Su","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/(SICI)1097-0223(199709)17:9<861::AID-PD169>3.0.CO;2-E","article-title":"A retrospective evaluation of maternal serum screening for the detection of fetal aneuploidy","volume":"17","author":"Suzumori","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pd.507","article-title":"Detection of maternal serum hCG glycoform variants in the second trimester of pregnancies affected by Down syndrome using a lectin immunoassay","volume":"23","author":"Talbot","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/pd.1970121005","article-title":"Second-trimester maternal serum immunoreactive Inhibin Aas a marker for fetal Down's syndrome","volume":"12","author":"Lith","year":"1992","journal-title":"Prenatal Diagnosis"},{"issue":"1 pt 1","key":"10.1002\/14651858.CD009925-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0002-9378(95)90108-6","article-title":"A prenatal trisomy 21 screening program using alpha-fetoprotein, human chorionic gonadotropin, and free estriol assays on maternal dried blood","volume":"172","author":"Verloes","year":"1995","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"9360","key":"10.1002\/14651858.CD009925-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0140-6736(03)12680-3","article-title":"Antenatal screening for Down's syndrome with the quadruple test","volume":"361","author":"Wald","year":"2003","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1471-0528.2004.00193.x","article-title":"SURUSS in perspective","volume":"111","author":"Wald","year":"2004","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1053\/j.semperi.2005.05.006","article-title":"SURUSS in perspective","volume":"29","author":"Wald","year":"2005","journal-title":"Seminars in Perinatology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0065|cit64","first-page":"56","article-title":"First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)","volume":"10","author":"Wald","year":"2003","journal-title":"Journal of Medical Screening"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0064|cit65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta7110","article-title":"First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)","volume":"7","author":"Wald","year":"2003","journal-title":"Health Technology Assessment"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1080\/01443619963824","article-title":"Maternal serum screening for Down syndrome in women aged 40 years and over","volume":"19","author":"Marcus","year":"1999","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/01443619965011","article-title":"The outcome of five years' implementation of maternal serum screening for Down's syndrome comparing actual age risks and mode of delivery","volume":"19","author":"Ward","year":"1999","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000048026","article-title":"Second-trimester maternal pregnancy-associated plasma protein a and Inhibin Aa levels in fetal trisomies","volume":"17","author":"Watanabe","year":"2002","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0002-9378(97)70002-4","article-title":"Elevated second-trimester dimeric Inhibin A levels identify Down syndrome pregnancies","volume":"177","author":"Wenstrom","year":"1997","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0029-7844(97)00250-0","article-title":"Free \u00df-hCG subunit versus intact hCG in Down syndrome screening","volume":"90","author":"Wenstrom","year":"1997","journal-title":"Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0029-7844(96)00519-4","article-title":"Second-trimester maternal serum CA-125 versus estriol in the multiple-marker screening test for Down syndrome","volume":"89","author":"Wenstrom","year":"1997","journal-title":"Obstetrics & Gynecology.89(3):359-63,"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0002-9378(99)70320-0","article-title":"Prospective evaluation of free \u00df-subunit of human chorionic gonadotropin and dimeric Inhibin A for aneuploidy detection","volume":"181","author":"Wenstrom","year":"1999","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1471-0528.1995.tb11362.x","article-title":"Fetal and maternal hCG concentration in aneuploid pregnancies","volume":"102","author":"Abbas","year":"1995","journal-title":"British Journal of Obstetrics and Gynaecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/01443610410001685475","article-title":"Maternal serum screening for trisomy 21 in women with a false positive result in last pregnancy","volume":"24","author":"Abdul-Hamid","year":"2004","journal-title":"Journal of Obstetrics & Gynaecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/(SICI)1097-0223(199904)19:4<334::AID-PD541>3.0.CO;2-E","article-title":"Maternal serum S100 protein in normal and Down syndrome pregnancies","volume":"19","author":"Abraha","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"857","key":"10.1002\/14651858.CD009925-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1259\/bjr.72.857.10505009","article-title":"Increased first trimester nuchal translucency: pregnancy and infant outcomes after routine screening for Down's syndrome in an unselected antenatal population","volume":"72","author":"Adekunle","year":"1999","journal-title":"British Journal of Radiology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/pd.1970130804","article-title":"First-trimester biochemical screening for fetal chromosome abnormalities and neural tube defects","volume":"13","author":"Aitken","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/(SICI)1097-0223(199611)16:11<1051::AID-PD988>3.0.CO;2-T","article-title":"Heat-stable and immunoreactive placental alkaline phosphatase in maternal serum from Down's syndrome and trisomy 18 pregnancies.[see comment]","volume":"16","author":"Aitken","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"19","key":"10.1002\/14651858.CD009925-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJM199605093341904","article-title":"Dimeric Inhibin A as a marker for Down's syndrome in early pregnancy","volume":"334","author":"Aitken","year":"1996","journal-title":"New England Journal of Medicine"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1515\/CCLM.2001.080","article-title":"Maternal serum screening for Down's syndrome, open neural tube defects and trisomy 18","volume":"39","author":"Akbas","year":"2001","journal-title":"Clinical Chemistry & Laboratory Medicine"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/(SICI)1097-0223(199811)18:11<1122::AID-PD414>3.0.CO;2-P","article-title":"Inhibin A and pro-alphaC Inhibin Ain Down syndrome and normal pregnancies","volume":"18","author":"Antona","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/01443619965002","article-title":"Pregnant women of 35 years of age or more: Maternal serum markers or amniocentesis?","volume":"19","author":"Antsaklis","year":"1999","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/ajmg.1320260304","article-title":"Maternal serum alpha-fetoprotein and fetal trisomy-21 in women 35 years and older: implications for alpha-fetoprotein screening programs","volume":"26","author":"Ashwood","year":"1987","journal-title":"American Journal of Medical Genetics"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0084|cit84","first-page":"174","article-title":"Triple marker","volume":"7","author":"Asrani","year":"2005","journal-title":"National Journal of Homoeopathy"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1469-0705.2001.00457.x","article-title":"Screening for Down syndrome using first-trimester ultrasound and second-trimester maternal serum markers in a low-risk population: a prospective longitudinal study","volume":"18","author":"Audibert","year":"2001","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000092472","article-title":"Umbilical cord diameter at 11-14 weeks of gestation: Relationship to nuchal translucency, ductus venous blood flow and chromosomal defects","volume":"21","author":"Axt","year":"2006","journal-title":"Fetal Diagnosis and Therapy"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1067\/mob.2002.123201","article-title":"A novel method for the detection of Down syndrome with the use of four serum markers","volume":"187","author":"Azuma","year":"2002","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"1-2","key":"10.1002\/14651858.CD009925-BIB0088|cit88","first-page":"59","article-title":"Maternal serum alpha fetoprotein among pregnant females in Alexandria","volume":"79","author":"Baghagho","year":"2004","journal-title":"Journal of the Egyptian Public Health Association"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/0002-9378(95)91334-3","article-title":"Normal nuchal thickness in the midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results","volume":"173","author":"Bahado","year":"1995","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"4 I","key":"10.1002\/14651858.CD009925-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0002-9378(96)80006-8","article-title":"Risk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results","volume":"175","author":"Bahado","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"2 I","key":"10.1002\/14651858.CD009925-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0002-9378(99)70237-1","article-title":"Nuchal thickness, urine \u00df-core fragment level, and maternal age for down syndrome screening","volume":"180","author":"Bahado","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1067\/mob.2002.121651","article-title":"The comprehensive midtrimester test: High-sensitivity Down syndrome test","volume":"186","author":"Bahado","year":"2002","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1053\/sper.2003.50013","article-title":"Combined serum and ultrasound screening for detection of fetal aneuploidy","volume":"27","author":"Bahado","year":"2003","journal-title":"Seminars in Perinatology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1023\/A:1009455912670","article-title":"Triple-test screening in in vitro fertilization pregnancies","volume":"18","author":"Bar-Hava","year":"2001","journal-title":"Journal of Assisted Reproduction and Genetics"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1111::AID-PD998>3.0.CO;2-X","article-title":"Down's syndrome screening marker levels following assisted reproduction","volume":"16","author":"Barkai","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/pd.1970151209","article-title":"Enhanced twin pregnancy detection within an open neural tube defect and Down syndrome screening protocol using free-\u00df hCG and AFP","volume":"15","author":"Barnabei","year":"1995","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF00451454","article-title":"Maternal levels of pregnancy-specific \u00df 1-glycoprotein (SP-1) are elevated in pregnancies affected by Down's syndrome","volume":"80","author":"Bartels","year":"1988","journal-title":"Human Genetics"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/pd.1970130207","article-title":"Adjustment formulae for maternal serum alpha-fetoprotein, human chorionic gonadotropin, and unconjugated oestriol to maternal weight and smoking","volume":"13","author":"Bartels","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0099|cit99","first-page":"897","article-title":"Ultrasound detection of fetal aneuploidy in women with elevated maternal serum alpha-fetoprotein","volume":"77","author":"Barth","year":"1991","journal-title":"Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/jmf.16.4.241.243-26","article-title":"Placental growth hormone in Down's syndrome screening","volume":"16","author":"Baviera","year":"2004","journal-title":"Journal of Maternal-Fetal & Neonatal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/(SICI)1096-8628(19980413)76:5<369::AID-AJMG1>3.0.CO;2-I","article-title":"Fetal gender impact on multiple-marker screening results","volume":"76","author":"Bazzett","year":"1998","journal-title":"American Journal of Medical Genetics"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1093\/humrep\/dei107","article-title":"First trimester biochemical screening for Down's syndrome in singleton pregnancies conceived by assisted reproduction","volume":"20","author":"Bellver","year":"2005","journal-title":"Human Reproduction."},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/0002-9378(95)90272-4","article-title":"Prenatal diagnosis of diverse chromosome abnormalities in a population of women identified by triple-marker testing as screen positive for Down syndrome","volume":"173","author":"Benn","year":"1995","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0104|cit104","first-page":"323","article-title":"Maternal serum screening for birth defects: results of a Connecticut regional program","volume":"60","author":"Benn","year":"1996","journal-title":"Connecticut Medicine"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/clinchem\/43.2.333","article-title":"Medians for second-trimester maternal serum alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol; differences between races or ethnic groups","volume":"43","author":"Benn","year":"1997","journal-title":"Clinical Chemistry"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1097-0223(199804)18:4<319::AID-PD261>3.0.CO;2-Q","article-title":"Preliminary evidence for associations between second-trimester human chorionic gonadotropin and unconjugated oestriol levels with pregnancy outcome in Down syndrome pregnancies","volume":"18","author":"Benn","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/1097-0223(200101)21:1<46::AID-PD984>3.0.CO;2-C","article-title":"Estimates for the sensitivity and false-positive rates for second trimester serum screening for Down syndrome and trisomy 18 with adjustment for cross-identification and double-positive results","volume":"21","author":"Benn","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0108|cit108","first-page":"1168","article-title":"Combined second-trimester biochemical and ultrasound screening for Down syndrome","volume":"100","author":"Benn","year":"2002","journal-title":"Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0109|cit109","first-page":"451","article-title":"Incorporation of inhibin-A in second-trimester screening for Down syndrome","volume":"101","author":"Benn","year":"2003","journal-title":"Obstetrics and Gynecology"},{"issue":"9360","key":"10.1002\/14651858.CD009925-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0140-6736(03)12718-3","article-title":"Improved antenatal screening for Down's syndrome","volume":"361","author":"Benn","year":"2003","journal-title":"Lancet"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/pd.1215","article-title":"Practical strategies in contingent sequential screening for Down syndrome","volume":"25","author":"Benn","year":"2005","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10897-005-6390-7","article-title":"Sequential Down syndrome screening: the importance of first and second trimester test correlations when calculating risk","volume":"14","author":"Benn","year":"2005","journal-title":"Journal of Genetic Counseling"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/pd.1970150609","article-title":"Analysis of maternal serum alpha-fetoprotein and free \u00df human chorionic gonadotrophin in the first trimester: implications for Down's syndrome screening","volume":"15","author":"Berry","year":"1995","journal-title":"Prenatal Diagnosis"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1471-0528.1997.tb12025.x","article-title":"Screening for Down's syndrome: changes in marker levels and detection rates between first and second trimesters","volume":"104","author":"Berry","year":"1997","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/j.1471-0528.1994.tb13042.x","article-title":"First trimester maternal serum pregnancy-associated plasma protein A and pregnancy-specific \u00df 1-glycoprotein in fetal trisomies","volume":"101","author":"Bersinger","year":"1994","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0923-2532(00)80038-1","article-title":"Glycosylation of pregnancy-associated plasma protein a (PAPP-A) and pregnancy-specific (\u00df)(1)-glycoprotein (SP1): Relevance for fetal down syndrome screening and for placental function studies","volume":"15","author":"Bersinger","year":"2000","journal-title":"Immuno-Analyse et Biologie Specialisee"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0117|cit117","first-page":"7","article-title":"Serum levels of placenta protein markers: The relevance of differences between spontaneous and after in vitro fertilization pregnancies for fetal trisomy screening","volume":"11","author":"Bersinger","year":"2001","journal-title":"Journal fur Fertilitat und Reproduktion"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/pd.547","article-title":"First-trimester maternal serum PAPP-A, SP1 and M-CSF levels in normal and trisomic twin pregnancies","volume":"23","author":"Bersinger","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/pd.910","article-title":"Maternal serum levels of placental proteins after in vitro fertilisation and their implications for prenatal screening","volume":"24","author":"Bersinger","year":"2004","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0120|cit120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immbio.2004.11.006","article-title":"First trimester serum concentrations of placental proteins in singleton and multiple IVF pregnancies: Implications for Down syndrome screening","volume":"20","author":"Bersinger","year":"2005","journal-title":"Immuno-Analyse et Biologie Specialisee"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ajog.2003.09.028","article-title":"An outcomes analysis of five prenatal screening strategies for trisomy 21 in women younger than 35 years","volume":"190","author":"Biggio","year":"2004","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0122|cit122","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00003081-200209000-00010","article-title":"Screening for chromosomal defects by fetal nuchal translucency at 11 to 14 weeks","volume":"45","author":"Bindra","year":"2002","journal-title":"Clinical Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/(SICI)1097-0223(199903)19:3<219::AID-PD512>3.0.CO;2-K","article-title":"Clinical follow-up of high mid-trimester maternal serum intact human chorionic gonadotrophin concentrations in singleton pregnancies","volume":"19","author":"Blundell","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0124|cit124","first-page":"25","article-title":"Maternal serum alpha-fetoprotein prenatal screening for Down syndrome","volume":"59","author":"Boots","year":"1989","journal-title":"Alabama Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0125|cit125","first-page":"235","article-title":"Role of ultrasound evaluation of nuchal translucency in prenatal diagnosis","volume":"29","author":"Borruto","year":"2002","journal-title":"Clinical & Experimental Obstetrics & Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1097\/00008480-199012000-00019","article-title":"Screening for Down's syndrome with maternal serum human chorionic gonadotropin at midtrimester","volume":"2","author":"Boue","year":"1990","journal-title":"Current Opinion in Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0127|cit127","first-page":"168","article-title":"Triple marker screening for fetal Down syndrome","volume":"9","author":"Bradley","year":"1994","journal-title":"International Pediatrics"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0128|cit128","first-page":"75","article-title":"Nuchal translucency and screening for Down's syndrome","volume":"8","author":"Braithwaite","year":"1996","journal-title":"Contemporary Reviews in Obstetrics and Gynaecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1469-0705.1995.05010009.x","article-title":"First-trimester Down's syndrome screening using nuchal translucency: a prospective study in women undergoing chorionic villus sampling","volume":"5","author":"Brambati","year":"1995","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0130|cit130","first-page":"155","article-title":"Sonography in the first trimester screening of trisomy 21 and other fetal aneuploidies. [Review] [73 refs]","volume":"2","author":"Brambati","year":"1996","journal-title":"Early Pregnancy"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-3782(95)01658-P","article-title":"Maternal serum Schwangerschafts protein-1 (SP1) and fetal chromosomal abnormalities at 10-13 weeks' gestation","volume":"43","author":"Brizot","year":"1995","journal-title":"Early Human Development."},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0132|cit132","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1471-0528.1995.tb09022.x","article-title":"First trimester maternal serum alpha-fetoprotein in fetal trisomies","volume":"102","author":"Brizot","year":"1995","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"3 Suppl","key":"10.1002\/14651858.CD009925-BIB0133|cit133","first-page":"85","article-title":"Evaluation of maternal serum alpha-fetoprotein and ultrasound examination to screen fetal chromosomal abnormalities","volume":"33","author":"Brizzi","year":"1989","journal-title":"Journal of Nuclear Medicine & Allied Sciences"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/pd.1970100406","article-title":"First-trimester maternal serum biochemical indicators in Down syndrome","volume":"10","author":"Brock","year":"1990","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/jms.8.3.163","article-title":"Correlations between first and second trimester markers for Down's syndrome screening","volume":"8","author":"Campogrande","year":"2001","journal-title":"Journal of Medical Screening"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1471-0528.1988.tb06601.x","article-title":"Low second trimester maternal serum unconjugated oestriol in pregnancies with Down's syndrome","volume":"95","author":"Canick","year":"1988","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/pd.1970150809","article-title":"Second-trimester levels of maternal urinary gonadotropin peptide in down syndrome pregnancy","volume":"15","author":"Canick","year":"1995","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0138|cit138","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1515\/CCLM.2002.103","article-title":"Comparison of first trimester, second trimester and integrated Down's syndrome screening results in unaffected pregnancies","volume":"40","author":"Canini","year":"2002","journal-title":"Clinical Chemistry & Laboratory Medicine"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/(SICI)1097-0223(199807)18:7<683::AID-PD327>3.0.CO;2-G","article-title":"Population screening for aneuploidy using maternal age and ultrasound","volume":"18","author":"Cans","year":"1998","journal-title":"Prenatal Diagnosis"},{"key":"10.1002\/14651858.CD009925-BIB0140|cit140","first-page":"261","article-title":"[Proposed normal values for alpha fetoprotein in maternal serum for the detection of neural tube closure defects and Down syndrome. Preliminary study]. [Spanish]","volume":"59","author":"Carreras de Paz","year":"1991","journal-title":"Ginecologia y Obstetricia de Mexico"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0141|cit141","first-page":"846","article-title":"Integrated screening for Down's syndrome","volume":"48","author":"Chen","year":"1999","journal-title":"Journal of Family Practice"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0142|cit142","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/pd.363","article-title":"The effect of ethnic origin on nuchal translucency at 10-14 weeks of gestation","volume":"22","author":"Chen","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/pd.798","article-title":"Ultrasound screening of fetal structural abnormalities at 12 to 14 weeks in Hong Kong","volume":"24","author":"Chen","year":"2004","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0144|cit144","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1028-4559(09)60103-0","article-title":"Impact of second-trimester maternal serum screening on prenatal diagnosis of Down syndrome and the use of amniocentesis in the Taiwanese population","volume":"44","author":"Chen","year":"2005","journal-title":"Taiwanese Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0145|cit145","first-page":"72","article-title":"A prospective evaluation of a second-trimester screening test for fetal Down syndrome using maternal serum alpha-fetoprotein, hCG, and unconjugated estriol","volume":"81","author":"Cheng","year":"1993","journal-title":"Obstetrics & Gynecology"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0146|cit146","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/(SICI)1097-0223(199910)19:10<955::AID-PD670>3.0.CO;2-X","article-title":"Elevated second-trimester maternal serum hCG in women undergoing haemodialysis","volume":"19","author":"Cheng","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0147|cit147","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0020-7292(03)00206-6","article-title":"Pregnancy outcomes with increased nuchal translucency after routine Down syndrome screening","volume":"84","author":"Cheng","year":"2004","journal-title":"International Journal of Gynaecology & Obstetrics"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0148|cit148","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0002-9378(03)00948-7","article-title":"Elevated maternal midtrimester serum free \u00df-human chorionic gonadotropin levels in vegetarian pregnancies that cause increased false-positive Down syndrome screening results","volume":"190","author":"Cheng","year":"2004","journal-title":"American Journal of Obstetrics & Gynecology."},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0149|cit149","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1067\/mob.2002.125240","article-title":"Double-positive maternal serum screening results for down syndrome and open neural tube defects: An indicator for fetal structural or chromosomal abnormalities and adverse obstetric outcomes","volume":"187","author":"Chitayat","year":"2002","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0150|cit150","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/pd.297","article-title":"The variation of risk estimates through pregnancy in second trimester maternal serum screening for Down syndrome","volume":"22","author":"Christiansen","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0151|cit151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pd.1600","article-title":"Human placental lactogen is a first-trimester maternal serum marker of Down syndrome","volume":"27","author":"Christiansen","year":"2007","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0152|cit152","first-page":"17","article-title":"The application of three-dimensional ultrasound to nuchal translucency thickness measurement at 10-14 weeks of gestation","volume":"5","author":"Chung","year":"2000","journal-title":"Prenatal and Neonatal Medicine"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0153|cit153","first-page":"575","article-title":"Blood screening of Down's syndrome (Trisomy 21) and reimbursement of karyotype for women under 38","volume":"91","author":"Anon","year":"1996","journal-title":"Revue Francaise de Gynecologie et d'Obstetrique"},{"key":"10.1002\/14651858.CD009925-BIB0154|cit154","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/S0378-3782(96)01819-1","article-title":"Detection of \u00df-core fragment in second trimester Down's syndrome pregnancies. [Review]","volume":"47 Suppl","author":"Cole","year":"1996","journal-title":"Early Human Development"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0155|cit155","first-page":"95","article-title":"Early screening for chromosomal abnormalities: New strategies combining biochemical, sonographic and doppler parameters","volume":"6","author":"Comas","year":"2001","journal-title":"Prenatal and Neonatal Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0156|cit156","first-page":"648","article-title":"Measurement of nuchal translucency as a single strategy in trisomy 21 screening: should we use any other marker?","volume":"100","author":"Comas","year":"2002","journal-title":"Obstetrics & Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0157|cit157","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/14722240208500465","article-title":"Early sonographic screening for chromosomal abnormalities","volume":"2","author":"Comas","year":"2002","journal-title":"Ultrasound Review of Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0158|cit158","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.ajog.2006.06.006","article-title":"Is there a nuchal translucency millimeter measurement above which there is no added benefit from first trimester serum screening?","volume":"195","author":"Comstock","year":"2006","journal-title":"American Journal of Obstetrics & Gynecology."},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0159|cit159","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00006254-199806000-00022","article-title":"Triple-marker test as screening for down syndrome: A meta-analysis","volume":"53","author":"Conde","year":"1998","journal-title":"Obstetrical and Gynecological Survey"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0160|cit160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/pd.1970110204","article-title":"Prenatal screening for chromosome abnormalities using maternal serum chorionic gonadotrophin, alpha-fetoprotein, and age","volume":"11","author":"Crossley","year":"1991","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0161|cit161","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/pd.1970130406","article-title":"Second-trimester unconjugated oestriol levels in maternal serum from chromosomally abnormal pregnancies using an optimized assay.[see comment]","volume":"13","author":"Crossley","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0162|cit162","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/(SICI)1097-0223(199611)16:11<1039::AID-PD985>3.0.CO;2-#","article-title":"Insulin-dependent diabetes mellitus and prenatal screening results: current experience from a regional screening programme","volume":"16","author":"Crossley","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0163|cit163","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/pd.313","article-title":"Maternal smoking: age distribution, levels of alpha-fetoprotein and human chorionic gonadotrophin, and effect on detection of Down syndrome pregnancies in second-trimester screening","volume":"22","author":"Crossley","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"8383","key":"10.1002\/14651858.CD009925-BIB0164|cit164","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0140-6736(84)92389-4","article-title":"Maternal serum alpha-fetoprotein measurement: a screening test for Down syndrome","volume":"i","author":"Cuckle","year":"1984","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0165|cit165","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1471-0528.1987.tb03115.x","article-title":"Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha-fetoprotein level","volume":"94","author":"Cuckle","year":"1987","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0166|cit166","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1471-0528.1987.tb02301.x","article-title":"Maternal serum alpha-fetoprotein and ethnic origin","volume":"94","author":"Cuckle","year":"1987","journal-title":"British Journal of Obstetrics and Gynaecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0167|cit167","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1471-0528.1990.tb01794.x","article-title":"The effect of smoking in pregnancy on maternal serum alpha-fetoprotein, unconjugated oestriol, human chorionic gonadotrophin, progesterone and dehydroepiandrosterone sulphate levels","volume":"97","author":"Cuckle","year":"1990","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0168|cit168","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1095::AID-PD997>3.0.CO;2-9","article-title":"Combining Inhibin A with existing second-trimester markers in maternal serum screening for Down's syndrome","volume":"16","author":"Cuckle","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0169|cit169","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/(SICI)1097-0223(199906)19:6<513::AID-PD579>3.0.CO;2-L","article-title":"Maternal serum activin A and follistatin levels in pregnancies with Down syndrome","volume":"19","author":"Cuckle","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0170|cit170","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/(SICI)1097-0223(199906)19:6<505::AID-PD572>3.0.CO;2-6","article-title":"Appropriate biochemical parameters in first-trimester screening for Down syndrome.[see comment]","volume":"19","author":"Cuckle","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0171|cit171","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/pd.1970101004","article-title":"Diagnosis and significance of cystic hygroma in the first trimester","volume":"10","author":"Cullen","year":"1990","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0172|cit172","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.7863\/jum.2004.23.10.1327","article-title":"Fetal nasal bone length in euploid and aneuploid fetuses between 11 and 20 weeks' gestation: a prospective study","volume":"23","author":"Cusick","year":"2004","journal-title":"Journal of Ultrasound in Medicine"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0173|cit173","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1469-0705.1997.10060375.x","article-title":"Screening for fetal anomalies by ultrasound at 14 and 21 weeks","volume":"10","author":"D'Ottavio","year":"1997","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0174|cit174","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0923-2532(01)80075-2","article-title":"Antenatal screening for Dawn's syndrome with serum markers: Influence of maternal weight, smoking habits and diabetes","volume":"16","author":"Dancoine","year":"2001","journal-title":"Immuno-Analyse et Biologie Specialisee"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0175|cit175","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/(SICI)1097-0223(199904)19:4<360::AID-PD556>3.0.CO;2-U","article-title":"First-trimester screening for down syndrome using nuchal translucency measurement with free \u00df-hCG and PAPP-A between 10 and 13 weeks of pregnancy - The combined test","volume":"19","author":"De","year":"1999","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0176|cit176","first-page":"22","article-title":"Down's syndrome: First trimester approach","volume":"13","author":"De","year":"2001","journal-title":"Italian Journal of Gynaecology and Obstetrics"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0177|cit177","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/jms.7.3.163","article-title":"Extent of correlation between first and second trimester markers for Down's syndrome screening","volume":"7","author":"Biasio","year":"2000","journal-title":"Journal of Medical Screening"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0178|cit178","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/(SICI)1097-0223(200003)20:3<186::AID-PD776>3.0.CO;2-A","article-title":"Co-variables in first trimester maternal serum screening","volume":"20","author":"Graaf","year":"1991","journal-title":"Prenatal Diagnosis."},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0179|cit179","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/(SICI)1097-0223(199905)19:5<458::AID-PD569>3.0.CO;2-A","article-title":"Early pregnancy screening for fetal aneuploidy with serum markers and nuchal translucency","volume":"19","author":"Graaf","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0180|cit180","doi-asserted-by":"crossref","first-page":"645","DOI":"10.7863\/jum.2001.20.6.645","article-title":"Combined use of genetic sonography and maternal serum triple-marker screening: an effective method for increasing the detection of trisomy 21 in women younger than 35 years.[see comment]","volume":"20","author":"DeVore","year":"2001","journal-title":"Journal of Ultrasound in Medicine."},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0181|cit181","first-page":"161","article-title":"Multiple marker screening","volume":"161","author":"Dickerson","year":"1994","journal-title":"Western Journal of Medicine"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0182|cit182","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1056\/NEJM198708063170603","article-title":"Screening for fetal Down's syndrome in pregnancy by measuring maternal serum alpha-fetoprotein levels","volume":"317","author":"Dimaio","year":"1987","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0183|cit183","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0002-9378(86)90655-1","article-title":"Maternal serum alpha-fetoprotein and fetal autosomal trisomies","volume":"154","author":"Doran","year":"1986","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0184|cit184","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000264328","article-title":"Abnormal biochemical serum screening versus 2nd-trimester ultrasound-detected minor anomalies as predictors of aneuploidy in low-risk women","volume":"11","author":"Drugan","year":"1996","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0185|cit185","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000264273","article-title":"Multiple marker screening in multifetal gestations: failure to predict adverse pregnancy outcomes","volume":"11","author":"Drugan","year":"1996","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0186|cit186","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/01443610120113300","article-title":"First-trimester pregnancy scanning as a screening tool for high-risk and abnormal pregnancies in a district general hospital setting","volume":"22","author":"Drysdale","year":"2002","journal-title":"Journal of Obstetrics & Gynaecology"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0187|cit187","first-page":"4","article-title":"Is the integrated test better for screening for Down's syndrome than the traditional triple test?","volume":"2","author":"Ebell","year":"1999","journal-title":"Evidence-Based Practice"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0188|cit188","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1471-0528.1998.tb09351.x","article-title":"First trimester sonographic detection of chromosomal abnormalities in an unselected population","volume":"105","author":"Economides","year":"1998","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0189|cit189","doi-asserted-by":"crossref","first-page":"415","DOI":"10.5858\/2004-128-415-EOADIA","article-title":"Evaluation of a dimeric inhibin-A assay for assessing fetal Down syndrome: establishment, comparison, and monitoring of median concentrations for normal pregnancies","volume":"128","author":"Erickson","year":"2004","journal-title":"Archives of Pathology & Laboratory Medicine"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0190|cit190","first-page":"20","article-title":"Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of \u00df-hCG and unconjugated estriol with controls: no need to adjust as with alpha-fetoprotein","volume":"3","author":"Evans","year":"1996","journal-title":"Journal of the Society for Gynecologic Investigation"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0191|cit191","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/uog.1991","article-title":"Fetal head-to-trunk volume ratio in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation","volume":"26","author":"Falcon","year":"2005","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0192|cit192","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/uog.2736","article-title":"Fetal tricuspid regurgitation at the 11 + 0 to 13 + 6-week scan: association with chromosomal defects and reproducibility of the method","volume":"27","author":"Falcon","year":"2006","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0193|cit193","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1471-0528.1998.tb10229.x","article-title":"The value of screening for Down's syndrome in a socioeconomically deprived area with a high ethnic population.[see comment]","volume":"105","author":"Ford","year":"1998","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0194|cit194","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0029-7844(97)00139-7","article-title":"Serum triple-marker screening in in vitro fertilization and naturally conceived pregnancies","volume":"90","author":"Frishman","year":"1997","journal-title":"Obstetrics & Gynecology"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0195|cit195","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1034\/j.1600-0412.2000.0790121124.x","article-title":"Detection of aneuploidy with fetal nuchal translucency and maternal serum markers in Japanese women","volume":"79","author":"Fukada","year":"2000","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0196|cit196","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/(SICI)1097-0223(199802)18:2<123::AID-PD221>3.0.CO;2-6","article-title":"Is maternal serum triple screening a better predictor of Down syndrome in female than in male fetuses?","volume":"18","author":"Ghidini","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0197|cit197","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/096914139500200407","article-title":"Screening for Down's syndrome: the first two years experience in Bristol","volume":"2","author":"Goldie","year":"1995","journal-title":"Journal of Medical Screening"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0198|cit198","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.7863\/jum.2004.23.12.1619","article-title":"Phenotypic characteristics of absent and hypoplastic nasal bones in fetuses with down syndrome: Description by 3-dimensional ultrasonography and clinical significance","volume":"23","author":"Gon\u00e7alves","year":"2004","journal-title":"Journal of Ultrasound in Medicine"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0199|cit199","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/pd.1970140509","article-title":"Second-trimester maternal serum screening using alpha-fetoprotein, human chorionic gonadotrophin, and unconjugated oestriol: experience of a regional programme","volume":"14","author":"Goodburn","year":"1994","journal-title":"Prenatal Diagnosis"},{"issue":"1-2","key":"10.1002\/14651858.CD009925-BIB0200|cit200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0378-3782(01)00251-1","article-title":"Maternal serum urea resistant alkaline phosphatase in Down syndrome pregnancy","volume":"67","author":"Grozdea","year":"2002","journal-title":"Early Human Development"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0201|cit201","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejogrb.2003.12.014","article-title":"Screening for trisomy 21 in Flanders: a 10 years review of 40.490 pregnancies screened by maternal serum","volume":"115","author":"Gyselaers","year":"2004","journal-title":"European Journal of Obstetrics, Gynecology, & Reproductive Biology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0202|cit202","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000080578","article-title":"Single-step maternal serum screening for trisomy 21 in the era of combined or integrated screening","volume":"58","author":"Gyselaers","year":"2004","journal-title":"Gynecologic and Obstetric Investigation"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0203|cit203","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1258\/096914106776179755","article-title":"Nuchal translucency thickness measurements for fetal aneuploidy screening: Log NT-MoM or Delta-NT, performer-specific medians and ultrasound training","volume":"13","author":"Gyselaers","year":"2006","journal-title":"Journal of Medical Screening"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0204|cit204","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/uog.2780","article-title":"Sequential triage in the first trimester may enhance advanced ultrasound scanning in population screening for trisomy 21","volume":"27","author":"Gyselaers","year":"2006","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0205|cit205","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/pd.1970151208","article-title":"Repeat maternal serum testing for Down's syndrome screening using multiple markers with special reference to free alpha and free \u00df-hCG","volume":"15","author":"Hackshaw","year":"1995","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0206|cit206","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/1097-0223(200101)21:1<58::AID-PD964>3.0.CO;2-9","article-title":"Repeat testing in antenatal screening for Down syndrome using dimeric inhibin-A in combination with other maternal serum markers","volume":"21","author":"Hackshaw","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0207|cit207","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJM199208273270902","article-title":"Prenatal screening for Down's syndrome with use of maternal serum markers","volume":"327","author":"Haddow","year":"1992","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0208|cit208","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1046\/j.1469-0705.1995.06050330.x","article-title":"Screening for chromosomal abnormalities in an unselected population by fetal nuchal translucency","volume":"6","author":"Hafner","year":"1995","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0209|cit209","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/(SICI)1097-0223(199809)18:9<893::AID-PD362>3.0.CO;2-E","article-title":"Comparison of urinary free \u00df (hCG) and \u00df-core (hCG) in prenatal screening for chromosomal abnormalities","volume":"18","author":"Hallahan","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0210|cit210","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1258\/000456306775141876","article-title":"Second-trimester Down's syndrome serum screening: double, triple or quadruple marker testing?","volume":"43","author":"Harrison","year":"2006","journal-title":"Annals of Clinical Biochemistry"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0211|cit211","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jsgi.2006.03.001","article-title":"Nuchal translucency and first-trimester screening","volume":"13","author":"Harry","year":"2006","journal-title":"Journal of the Society for Gynecologic Investigation"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0212|cit212","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/pd.1970150104","article-title":"Maternal urinary \u00df-core fragment of hCG\/creatinine ratios and fetal chromosomal abnormalities in the second trimester of pregnancy","volume":"15","author":"Hayashi","year":"1995","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0213|cit213","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1471-0528.1996.tb09810.x","article-title":"Maternal urinary free \u00df-subunit of human chorionic gonadotrophin: Creatinine ratios and fetal chromosomal abnormalities in the second trimester of pregnancy","volume":"103","author":"Hayashi","year":"1996","journal-title":"British Journal of Obstetrics and Gynaecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0214|cit214","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000264439","article-title":"Results and views of women in population-wide pregnancy screening for trisomy 21 in east Finland","volume":"12","author":"Heikkila","year":"1997","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0215|cit215","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0015-0282(16)58508-2","article-title":"Effect of in vitro fertilization on human chorionic gonadotropin serum concentrations and Down's syndrome screening","volume":"66","author":"Heinonen","year":"1996","journal-title":"Fertility and Sterility"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0216|cit216","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/1097-0223(200010)20:10<781::AID-PD908>3.0.CO;2-Z","article-title":"Combined first trimester nuchal translucency and second trimester biochemical screening tests among normal pregnancies","volume":"20","author":"Herman","year":"2000","journal-title":"Prenatal Diagnosis."},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0217|cit217","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000069377","article-title":"Correlation and overlapping between nuchal translucency and triple test among Down syndrome-affected pregnancies","volume":"18","author":"Herman","year":"2003","journal-title":"Fetal Diagnosis and Therapy"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0218|cit218","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/pd.1970121106","article-title":"Screening for fetal Down syndrome with maternal serum hCG and oestriol: a prospective study","volume":"12","author":"Herrou","year":"1992","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0219|cit219","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0002-9378(85)90119-X","article-title":"Maternal serum alpha-fetoprotein screening of fetal trisomies","volume":"153","author":"Hershey","year":"1985","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0220|cit220","first-page":"177","article-title":"Combining maternal age and serum alpha-fetoprotein to predict the risk of Down syndrome","volume":"68","author":"Hershey","year":"1986","journal-title":"Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0221|cit221","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1479-828X.1993.tb02117.x","article-title":"Nuchal translucency in the first trimester","volume":"33","author":"Hewitt","year":"1993","journal-title":"Australian & New Zealand Journal of Obstetrics & Gynaecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0222|cit222","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/pd.1970120312","article-title":"CA-125 as a maternal serum marker for Down's syndrome in the first and second trimesters","volume":"12","author":"Hogdall","year":"1992","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0223|cit223","first-page":"461","article-title":"Screening tests in pregnancy","volume":"23","author":"Anon","year":"2001","journal-title":"Hong Kong Practitioner"},{"issue":"7235","key":"10.1002\/14651858.CD009925-BIB0224|cit224","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/bmj.320.7235.606","article-title":"Six year survey of screening for Down's syndrome by maternal age and mid-trimester ultrasound scans","volume":"320","author":"Howe","year":"2000","journal-title":"BMJ"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0225|cit225","first-page":"598","article-title":"[Antenatal screening of maternal alpha-fetoprotein with dried-blood spot samples on filter paper]. [Chinese]","volume":"90","author":"Hsiao","year":"1991","journal-title":"Journal of the Formosan Medical Association"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0226|cit226","first-page":"234","article-title":"Maternal urine alpha-fetoprotein concentrations between 14 and 21 weeks of gestation","volume":"22","author":"Hsieh","year":"1999","journal-title":"Changgeng Yi Xue Za Zhi"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0227|cit227","first-page":"181","article-title":"Influence of maternal age and weight on second-trimester serum alpha-fetoprotein, total and free \u00df human chorionic gonadotropin levels","volume":"20","author":"Hsu","year":"1997","journal-title":"Changgeng Yi Xue Za Zhi."},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0228|cit228","first-page":"277","article-title":"Midtrimester maternal serum free \u00df-human chorionic gonadotropin levels: normal reference values for Taiwanese women","volume":"21","author":"Hsu","year":"1998","journal-title":"Changgeng Yi Xue Za Zhi"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0229|cit229","first-page":"11","article-title":"Urine free \u00df-human chorionic gonadotropin levels between 14 and 21 weeks of gestation in Taiwanese pregnancies","volume":"22","author":"Hsu","year":"1999","journal-title":"Changgeng Yi Xue Za Zhi"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0230|cit230","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/pd.537","article-title":"Maternal serum marker medians in Aboriginal Canadian women","volume":"23","author":"Huang","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0231|cit231","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/uog.1720","article-title":"Doppler assessment of cardiac function at 11-14 weeks' gestation in fetuses with normal and increased nuchal translucency","volume":"24","author":"Huggon","year":"2004","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0232|cit232","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/humrep\/deg153","article-title":"Maternal serum hCG and alpha-fetoprotein levels in pregnancies conceived after IVF or ICSI with fresh and frozen-thawed embryos","volume":"18","author":"Hui","year":"2003","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0233|cit233","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/uog.1846","article-title":"Nuchal translucency in pregnancies conceived after assisted reproduction technology","volume":"25","author":"Hui","year":"2005","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0234|cit234","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ehbc.2004.02.021","article-title":"Combined serum and nuchal translucency screening in the first trimester achieves 85% to 90% detection rate for Down and Edward syndromes","volume":"8","author":"Hult\u00e9n","year":"2004","journal-title":"Evidence-Based Healthcare"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0235|cit235","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S0301-5629(03)01048-2","article-title":"Nuchal translucence incorporated into a one-stage multifactorial screening model for Down syndrome prediction at second-trimester pregnancy","volume":"29","author":"Hung","year":"2003","journal-title":"Ultrasound in Medicine & Biology"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0236|cit236","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/pd.1970131004","article-title":"Serum PAPP-A measurements in first-trimester screening for Down syndrome","volume":"13","author":"Hurley","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0237|cit237","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/pd.994","article-title":"Second-trimester prenatal screening markers for Down syndrome in women with insulin-dependent diabetes mellitus","volume":"24","author":"Huttly","year":"2004","journal-title":"Prenatal Diagnosis"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0238|cit238","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1515\/JPM.2004.137","article-title":"Evaluation of second trimester maternal serum screening for Down's Syndrome using the Spiegelhalter-Knill-Jones (S-KJ) approach","volume":"32","author":"Hwa","year":"2004","journal-title":"Journal of Perinatal Medicine"},{"issue":"Suppl.","key":"10.1002\/14651858.CD009925-BIB0239|cit239","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/S0378-3782(96)01818-X","article-title":"Urinary analysis for Down's syndrome: Is the measurement of urinary \u00df-core the future of biochemical screening for Down's syndrome","volume":"47","author":"Iles","year":"1996","journal-title":"Early Human Development"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0240|cit240","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/01443619409027596","article-title":"Second trimester maternal serum placental alkaline phosphatase concentrations in Down's syndrome","volume":"14","author":"Ind","year":"1994","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0241|cit241","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/14722240500190673","article-title":"Fetal nasal bone: Review of first trimester findings","volume":"5","author":"Jean","year":"2005","journal-title":"Ultrasound Review of Obstetrics and Gynecology"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0242|cit242","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/pd.1970110706","article-title":"First-trimester maternal serum alpha-fetoprotein and chorionic gonadotropin in aneuploid pregnancies","volume":"11","author":"Johnson","year":"1991","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0243|cit243","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0002-9378(12)90906-0","article-title":"First-trimester simple hygroma: cause and outcome","volume":"168","author":"Johnson","year":"1993","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0244|cit244","first-page":"501","article-title":"MULTISCAN--a Scandinavian multicenter second trimester obstetric ultrasound and serum screening study","volume":"78","author":"Jorgensen","year":"1999","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0245|cit245","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1034\/j.1600-0412.1998.770504.x","article-title":"Nuchal translucency as a screening test for chromosomal abnormalities in a routine first trimester ultrasound examination","volume":"77","author":"Josefsson","year":"1998","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0246|cit246","first-page":"257","article-title":"First-trimester Down's syndrome screening by fetal nuchal translucency measurement in Taiwan","volume":"100","author":"Jou","year":"2001","journal-title":"Journal of the Formosan Medical Association"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0247|cit247","first-page":"156","article-title":"[Screening by maternal serum markers for Down's syndrome]. [Chinese]","volume":"25","author":"Liu","year":"2003","journal-title":"Chung-Kuo i Hsueh Ko Hsueh Yuan Hsueh Pao Acta Academiae Medicinae Sinicae"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0248|cit248","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/01.AOG.0000191301.63871.c6","article-title":"Relation between increased fetal nuchal translucency thickness and chromosomal defects.[see comment]","volume":"107","author":"Kagan","year":"2006","journal-title":"Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0249|cit249","first-page":"181","article-title":"Study of the efficiency of screening for trisomy 21 based on maternal serum levels of AFP and hCG combined with maternal age","volume":"18","author":"Kautzmann","year":"1995","journal-title":"Journal of Clinical Ligand Assay"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0250|cit250","first-page":"274","article-title":"Maternal serum screening for neural tube defects and Down syndrome","volume":"5","author":"Keith","year":"1992","journal-title":"Clinical Laboratory Science"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0251|cit251","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000078499","article-title":"Nasal bone measurement during the 1st trimester: is it useful?","volume":"58","author":"Kelekci","year":"2004","journal-title":"Gynecologic & Obstetric Investigation"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0252|cit252","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/0002-9378(95)91376-9","article-title":"Triple marker (alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin) versus alpha-fetoprotein plus free-\u00df subunit in second-trimester maternal serum screening for fetal Down syndrome: a prospective comparison study.[see comment]","volume":"173","author":"Kellner","year":"1995","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0253|cit253","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0002-9378(95)90007-1","article-title":"The advantages of using triple-marker screening for chromosomal abnormalities","volume":"172","author":"Kellner","year":"1995","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0254|cit254","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/(SICI)1097-0223(199712)17:12<1135::AID-PD217>3.0.CO;2-E","article-title":"Levels of urinary \u00df-core fragment, total oestriol, and the ratio of the two in second-trimester screening for Down syndrome","volume":"17","author":"Kellner","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0255|cit255","first-page":"23","article-title":"Maternal serum alpha fetoprotein screening for fetal down syndrome","volume":"13","author":"Knight","year":"1990","journal-title":"Journal of Clinical Immunoassay"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0256|cit256","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/jms.8.1.2","article-title":"Clinical validation of a new dimeric inhibin-A assay suitable for second trimester Down's syndrome screening","volume":"8","author":"Knight","year":"2001","journal-title":"Journal of Medical Screening"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0257|cit257","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/pd.1305","article-title":"Integrated serum screening for Down syndrome in primary obstetric practice","volume":"25","author":"Knight","year":"2005","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0258|cit258","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/01.gco.0000192966.29449.01","article-title":"First-trimester screening: Lessons from clinical trials and implementation","volume":"18","author":"Koos","year":"2006","journal-title":"Current Opinion in Obstetrics and Gynecology"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0259|cit259","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/(SICI)1097-0223(199609)16:9<797::AID-PD948>3.0.CO;2-M","article-title":"Nuchal translucency cannot be used as a screening test for chromosomal abnormalities in the first trimester of pregnancy in a routine ultrasound practice.[see comment]","volume":"16","author":"Kornman","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0260|cit260","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<135::AID-PD41>3.0.CO;2-P","article-title":"Maternal urinary \u00df-core hCG in chromosomally abnormal pregnancies in the first trimester","volume":"17","author":"Kornman","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0261|cit261","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<176::AID-AJMG10>3.0.CO;2-M","article-title":"Effect of adjustment of maternal serum alpha-fetoprotein levels in insulin-dependent diabetes mellitus","volume":"75","author":"Kramer","year":"1998","journal-title":"American Journal of Medical Genetics"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0262|cit262","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0002-9378(96)70436-2","article-title":"First-trimester Down syndrome screening: free \u00df-human chorionic gonadotropin and pregnancy-associated plasma protein A","volume":"174","author":"Krantz","year":"1996","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0263|cit263","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/pd.1188","article-title":"Maternal weight and ethnic adjustment within a first-trimester Down syndrome and trisomy 18 screening program","volume":"25","author":"Krantz","year":"2005","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0264|cit264","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/pd.1970130306","article-title":"Racial differences in maternal serum human chorionic gonadotropin and unconjugated oestriol levels","volume":"13","author":"Kulch","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0265|cit265","first-page":"69","article-title":"Down syndrome screening in Singapore--the effectiveness of a second trimester serum screening policy modelled on 29,360 pregnancies in KK Women's and Children's Hospital","volume":"39","author":"Lai","year":"1998","journal-title":"Singapore Medical Journal"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0266|cit266","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1023\/A:1024813708875","article-title":"First-trimester screening for down syndrome in singleton pregnancies achieved by intrauterine insemination","volume":"20","author":"Lai Tsung","year":"2003","journal-title":"Journal of Assisted Reproduction and Genetics"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0267|cit267","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/pd.1480","article-title":"Maternal serum ADAM12 levels in Down and Edwards' syndrome pregnancies at 9-12 weeks' gestation","volume":"26","author":"Laigaard","year":"2006","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0268|cit268","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/pd.1540","article-title":"ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome","volume":"26","author":"Laigaard","year":"2006","journal-title":"Prenatal Diagnosis"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0269|cit269","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/(SICI)1097-0223(199712)17:12<1101::AID-PD195>3.0.CO;2-S","article-title":"Second-trimester maternal urinary gonadotrophin peptide screening for fetal Down syndrome in Asian women","volume":"17","author":"Lam","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0270|cit270","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/(SICI)1097-0223(199806)18:6<585::AID-PD305>3.0.CO;2-R","article-title":"Second-trimester maternal serum alpha-fetoprotein and human chorionic gonadotrophin screening for Down's syndrome in Hong Kong","volume":"18","author":"Lam","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0271|cit271","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1093\/humrep\/14.8.2120","article-title":"Maternal serum alpha-fetoprotein and human chorionic gonadotrophin in pregnancies conceived after intracytoplasmic sperm injection and conventional in-vitro fertilization","volume":"14","author":"Lam","year":"1999","journal-title":"Human Reproduction"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0272|cit272","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/(SICI)1097-0223(199905)19:5<463::AID-PD574>3.0.CO;2-Q","article-title":"Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women","volume":"19","author":"Lam","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0273|cit273","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/1097-0223(200006)20:6<487::AID-PD853>3.0.CO;2-2","article-title":"Acceptability of serum screening as an alternative to cytogenetic diagnosis of down syndrome among women 35 years or older in Hong Kong","volume":"20","author":"Lam","year":"2000","journal-title":"Prenatal Diagnosis."},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0274|cit274","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/pd.120","article-title":"The effect of fetal gender on second-trimester maternal serum inhibin-A concentration","volume":"21","author":"Lam","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0275|cit275","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/096914139600300202","article-title":"Second trimester levels of maternal serum inhibin A, total inhibin, alpha inhibin precursor, and activin in Down's syndrome pregnancy","volume":"3","author":"Lambert-Messerlian","year":"1996","journal-title":"Journal of Medical Screening"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0276|cit276","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1530\/eje.0.1380425","article-title":"Second trimester levels of maternal serum total activin A and placental inhibin\/activin alpha and \u00dfA subunit messenger ribonucleic acids in Down syndrome pregnancy","volume":"138","author":"Lambert","year":"1998","journal-title":"European Journal of Endocrinology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0277|cit277","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000083911","article-title":"2nd-trimester maternal serum human chorionic gonadotropin and alpha-fetoprotein levels in male and female fetuses with Down syndrome","volume":"20","author":"Lehavi","year":"2005","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0278|cit278","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000089064","article-title":"Higher median levels of free \u00df-hCG and PAPP-A in the first trimester of pregnancy in a Chinese ethnic group. Implication for first trimester combined screening for Down's syndrome in the Chinese population","volume":"21","author":"Leung","year":"2006","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0279|cit279","first-page":"455","article-title":"Maternal serum markers and prenatal screening for Down syndrome","volume":"50","author":"Leymarie","year":"1993","journal-title":"Archives Francaises de Pediatrie"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0280|cit280","first-page":"252","article-title":"[Clinical uses of maternal serum markers in the prenatal diagnosis] [Chinese]","volume":"33","author":"Li","year":"1998","journal-title":"Chung-Hua Fu Chan Ko Tsa Chih"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0281|cit281","first-page":"631","article-title":"[Measurement of pregnancy-associated plasma protein A in maternal peripheral blood and Down syndrome] [Chinese]","volume":"34","author":"Li","year":"1999","journal-title":"Chung-Hua Fu Chan Ko Tsa Chih"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0282|cit282","first-page":"655","article-title":"[AFP, uE3, \u00df-hCG levels applied for prenatal diagnosis of Down's syndrome]. [Chinese]","volume":"32","author":"Liao","year":"1997","journal-title":"Chung-Hua Fu Chan Ko Tsa Chih"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0283|cit283","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1093\/humrep\/16.7.1501","article-title":"First-trimester screening for trisomy 21 in singleton pregnancies achieved by assisted reproduction","volume":"16","author":"Liao","year":"2001","journal-title":"Human Reproduction"},{"issue":"13","key":"10.1002\/14651858.CD009925-BIB0284|cit284","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/pd.497","article-title":"Nuchal index: a gestational age independent ultrasound marker for the detection of Down syndrome","volume":"22","author":"Lim","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0285|cit285","first-page":"801","article-title":"Screening for maternal serum alpha-fetoprotein: what about the low side?","volume":"136","author":"Lippman","year":"1987","journal-title":"Canadian Medical Association Journal"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0286|cit286","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/ajmg.1320310128","article-title":"California's experience with low MS-AFP results","volume":"31","author":"Lustig","year":"1988","journal-title":"American Journal of Medical Genetics"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0287|cit287","first-page":"63","article-title":"Sensitivity and specificity of screening for Down syndrome with alpha-fetoprotein, hCG, unconjugated estriol, and maternal age.[see comment]","volume":"77","author":"MacDonald","year":"1991","journal-title":"Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0288|cit288","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/pd.1970140311","article-title":"Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein A, markers for fetal Down syndrome at 8-14 weeks","volume":"14","author":"Macintosh","year":"1994","journal-title":"Prenatal Diagnosis"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0289|cit289","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/(SICI)1097-0223(199705)17:5<401::AID-PD40>3.0.CO;2-M","article-title":"Urinary \u00df-core hCG: Screening for aneuploidies in early pregnancy (11-14 weeks' gestation)","volume":"17","author":"Macintosh","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0290|cit290","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/0002-9378(90)90700-H","article-title":"Maternal serum Down syndrome screening: free \u00df-protein is a more effective marker than human chorionic gonadotropin.[see comment]","volume":"163","author":"Macri","year":"1990","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0291|cit291","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/pd.1970140204","article-title":"Maternal serum free \u00df hCG screening: results of studies including 480 cases of Down syndrome.[see comment]","volume":"14","author":"Macri","year":"1994","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0292|cit292","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/000456329202900319","article-title":"Early detection of Down's syndrome using free \u00df human choriogonadotropin","volume":"19","author":"Spencer","year":"1992","journal-title":"Annals of Clinical Biochemistry"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0293|cit293","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0002-9378(96)70429-5","article-title":"Prenatal maternal dried blood screening with alpha-fetoprotein and free \u00df-human chorionic gonadotropin for open neural tube defect and Down syndrome","volume":"174","author":"Macri","year":"1996","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0294|cit294","first-page":"117","article-title":"Ultrasound clinics. Fetal nuchal fold translucency screening","volume":"43","author":"Malone","year":"1998","journal-title":"Contemporary OB\/GYN"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0295|cit295","first-page":"1066","article-title":"First-trimester sonographic screening for Down syndrome","volume":"102","author":"Malone","year":"2003","journal-title":"Obstetrics and Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0296|cit296","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000053941","article-title":"Pregnancy outcome and prognosis in fetuses with increased first-trimester nuchal translucency","volume":"16","author":"Mangione","year":"2001","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0297|cit297","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/humrep\/16.4.691","article-title":"Comparison of triple serum screening and pregnancy outcome in oocyte donation versus IVF pregnancies","volume":"16","author":"Maymon","year":"2001","journal-title":"Human Reproduction"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0298|cit298","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/pd.61","article-title":"Does a 'notched' nuchal translucency indicate Down syndrome fetuses or other adverse pregnancy outcome?","volume":"21","author":"Maymon","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0299|cit299","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/humrep\/17.4.1081","article-title":"Serial first- and second-trimester Down's syndrome screening tests among IVF-versus naturally-conceived singletons","volume":"17","author":"Maymon","year":"2002","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0300|cit300","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/pd.809","article-title":"Integrated first- and second-trimester Down syndrome screening test among unaffected IVF pregnancies","volume":"24","author":"Maymon","year":"2004","journal-title":"Prenatal Diagnosis"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0301|cit301","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/pd.1256","article-title":"Predicting the result of additional second-trimester markers from a woman's first-trimester marker profile: A new concept in Down syndrome screening","volume":"25","author":"Maymon","year":"2005","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0302|cit302","first-page":"70","article-title":"Prenatal screening using maternal serum alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol: Two-year experience in a health maintenance organization","volume":"5","author":"McDuffie","year":"1996","journal-title":"Journal of Maternal-Fetal Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0303|cit303","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/clinchem\/48.4.653","article-title":"Accuracy of expected risk of Down syndrome using the second-trimester triple test","volume":"48","author":"Meier","year":"2002","journal-title":"Clinical Chemistry"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0304|cit304","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/0002-9378(84)90530-1","article-title":"An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities","volume":"148","author":"Merkatz","year":"1984","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0305|cit305","first-page":"365","article-title":"The fetal nasal bone in the first trimester - Precise assessment using 3D sonography","volume":"26","author":"Merz","year":"2005","journal-title":"Ultraschall in der Medizin"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0306|cit306","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1053\/plac.2001.0684","article-title":"Three-dimensional ultrasound measurement of the placental volume in early pregnancy: method and correlation with biochemical placenta parameters","volume":"22","author":"Metzenbauer","year":"2001","journal-title":"Placenta"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0307|cit307","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1046\/j.1469-0705.2002.00655.x","article-title":"First-trimester placental volume as a marker for chromosomal anomalies: preliminary results from an unselected population","volume":"19","author":"Metzenbauer","year":"2002","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0308|cit308","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1471-0528.1999.tb08331.x","article-title":"Second trimester maternal serum \u00df human chorionic gonadotrophin and pregnancy outcome","volume":"106","author":"Mikic","year":"1999","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0309|cit309","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/pd.1970110304","article-title":"Alteration in age-specific risks for chromosomal trisomy by maternal serum alpha-fetoprotein and human chorionic gonadotropin screening","volume":"11","author":"Miller","year":"1991","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0310|cit310","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0002-9378(89)90501-2","article-title":"Predictive values relative risks and overall benefits of high and low maternal serum alpha fetoprotein screening in singleton pregnancies - new epidemiological data","volume":"161","author":"Milunsky","year":"1989","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0311|cit311","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000264310","article-title":"Maternal serum triple analyte screening and adverse pregnancy outcome","volume":"11","author":"Milunsky","year":"1996","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0312|cit312","first-page":"527","article-title":"[A study on the screening of prenatal trisomy 21 using the fucosylated alpha-fetoprotein ratio measured by a liquid-phase binding assay]. [Japanese]","volume":"77","author":"Minobe","year":"2002","journal-title":"Hokkaido Igaku Zasshi - Hokkaido Journal of Medical Science"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0313|cit313","first-page":"1042","article-title":"Multicenter study for maternal serum triple markers to establish Japanese standards: Maternal serum marker study group, Japan Association of Prenatal Diagnostics","volume":"51","author":"Miyamura","year":"1999","journal-title":"Acta Obstetrica et Gynaecologica Japonica"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0314|cit314","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000020856","article-title":"Maternal serum placental growth hormone and insulinlike growth factor binding proteins 1 and 3 in pregnancies affected by fetal aneuploidy and other abnormalities: implications for prenatal diagnosis of trisomy 21","volume":"13","author":"Moghadam","year":"1998","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0315|cit315","first-page":"266","article-title":"Nuchal translucency in multiple pregnancies","volume":"41","author":"Monni","year":"2000","journal-title":"Croatian Medical Journal"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0316|cit316","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/14722240208500480","article-title":"New ultrasonographic markers of aneuploidies: Nasal bones","volume":"2","author":"Monni","year":"2002","journal-title":"Ultrasound Review of Obstetrics and Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0317|cit317","first-page":"298","article-title":"Effectiveness of combining maternal serum alpha-fetoprotein and hCG in a second-trimester screening program for Down syndrome","volume":"84","author":"Mooney","year":"1994","journal-title":"Obstetrics and Gynecology"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0318|cit318","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/pd.1970140721","article-title":"Do racial differences exist in second-trimester maternal hCG levels? A study of 23,369 women","volume":"14","author":"Muller","year":"1994","journal-title":"Prenatal Diagnosis"},{"key":"10.1002\/14651858.CD009925-BIB0319|cit319","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/S0378-3782(96)01817-8","article-title":"Prenatal screening for Down syndrome: should first trimester ultrasound replace maternal serum screening?","volume":"47 Suppl","author":"Muller","year":"1996","journal-title":"Early Human Development"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0320|cit320","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1086::AID-PD704>3.0.CO;2-T","article-title":"Maternal serum s100b protein is ineffective for Down syndrome screening","volume":"19","author":"Muller","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0321|cit321","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/pd.451","article-title":"Down syndrome maternal serum marker screening after 18 weeks' gestation","volume":"22","author":"Muller","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0322|cit322","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/pd.438","article-title":"Second trimester trisomy 21 maternal serum marker screening. Results of a countrywide study of 854,902 women","volume":"22","author":"Muller","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"13","key":"10.1002\/14651858.CD009925-BIB0323|cit323","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/pd.756","article-title":"Medically assisted reproduction and second-trimester maternal serum marker screening for Down syndrome","volume":"23","author":"Muller","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0324|cit324","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000063185","article-title":"Application of ductus venosus Doppler velocimetry for the detection of fetal aneuploidy in the first trimester of pregnancy","volume":"17","author":"Murta","year":"2002","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0325|cit325","first-page":"39","article-title":"Fetuses with cystic hygroma. A retrospective study","volume":"42","author":"Musone","year":"2000","journal-title":"Panminerva Medica"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0326|cit326","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/clinchem\/32.7.1412","article-title":"Alpha-fetoprotein: an enhanced-sensitivity assay for neural tube defect and Down syndrome evaluation","volume":"32","author":"Musto","year":"1986","journal-title":"Clinical Chemistry"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0327|cit327","first-page":"233","article-title":"Identification of haptoglobin alpha-2FF variants in mid-trimester maternal serum as potential markers for Down syndrome","volume":"1","author":"Myrick","year":"1990","journal-title":"Applied & Theoretical Electrophoresis"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0328|cit328","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1115::AID-PD3>3.0.CO;2-6","article-title":"Refinements in managing maternal weight adjustment for interpreting prenatal screening results","volume":"16","author":"Neveux","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0329|cit329","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1097-0223(199601)16:1<29::AID-PD801>3.0.CO;2-K","article-title":"Multiple marker screening for Down syndrome in twin pregnancies","volume":"16","author":"Neveux","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0330|cit330","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1373\/clinchem.2004.031260","article-title":"Evaluation of human chorionic gonadotropin \u00df-subunit mRNA concentrations in maternal serum in aneuploid pregnancies: a feasibility study","volume":"50","author":"Ng","year":"2004","journal-title":"Clinical Chemistry"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0331|cit331","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000263659","article-title":"Fetal nuchal oedema associated malformations and chromosomal defects","volume":"7","author":"Nicolaides","year":"1992","journal-title":"Fetal Diagnosis and Therapy"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0332|cit332","first-page":"145","article-title":"One-stop clinic for assessment of risk of chromosomal defects at 12 weeks of gestation","volume":"5","author":"Nicolaides","year":"2000","journal-title":"Prenatal and Neonatal Medicine"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0333|cit333","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajog.2004.03.090","article-title":"Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities","volume":"191","author":"Nicolaides","year":"2004","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0334|cit334","first-page":"1","article-title":"[First trimester diagnosis of chromosomal defects][Polish]","volume":"76","author":"Nicolaides","year":"2005","journal-title":"Ginekologia Polska.76(1):1-8,"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0335|cit335","first-page":"423","article-title":"[Sonographic features of chromosomal defects at 11(+0) to 13(+6) weeks of gestation] [Polish]","volume":"76","author":"Nicolaides","year":"2005","journal-title":"Ginekologia Polska"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0336|cit336","first-page":"593","article-title":"[Increased nuchal translucency with normal karyotype]. [Polish]","volume":"76","author":"Nicolaides","year":"2005","journal-title":"Ginekologia Polska"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0337|cit337","first-page":"179","article-title":"[Fetal nuchal translucency]. [Polish]","volume":"76","author":"Nicolaides","year":"2005","journal-title":"Ginekologia Polska"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0338|cit338","first-page":"257","article-title":"[Fetal nuchal translucency thickness and risk for chromosomal defects]. [Polish]","volume":"76","author":"Nicolaides","year":"2005","journal-title":"Ginekologia Polska.76(4):257-63,"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0339|cit339","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1053\/j.semperi.2005.06.001","article-title":"First-trimester screening for chromosomal abnormalities","volume":"29","author":"Nicolaides Kypros","year":"2005","journal-title":"Seminars in Perinatology (Philadelphia)"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0340|cit340","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/S0015-0282(01)02871-0","article-title":"First-trimester screening for Down's syndrome in in vitro fertilization pregnancies","volume":"76","author":"Niemimaa","year":"2001","journal-title":"Fertility & Sterility"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0341|cit341","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/pd.286","article-title":"Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein A in twin pregnancies in the first trimester","volume":"22","author":"Niemimaa","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0342|cit342","first-page":"664","article-title":"The influence of smoking on the pregnancy-associated plasma protein A, free \u00df human chorionic gonadotrophin and nuchal translucency","volume":"110","author":"Niemimaa","year":"2003","journal-title":"BJOG"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0343|cit343","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1471-0528.1997.tb11989.x","article-title":"Maternal serum free \u00df-hCG at 10 to 14 weeks of gestation in trisomic twin pregnancies","volume":"104","author":"Noble","year":"1997","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0344|cit344","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1399-0004.1990.tb03388.x","article-title":"Maternal serum markers in screening for Down syndrome","volume":"37","author":"Norgaard","year":"1990","journal-title":"Clinical Genetics"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0345|cit345","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/pd.1970120911","article-title":"Maternal serum CA 125 for aneuploidy detection in early pregnancy","volume":"12","author":"Norton","year":"1992","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0346|cit346","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/(SICI)1096-8628(19971212)73:2<109::AID-AJMG1>3.0.CO;2-P","article-title":"Differential increases in AFP, hCG, and uE3 in twin pregnancies: Impact on attempts to quantify Down syndrome screening calculations","volume":"73","author":"Brien","year":"1997","journal-title":"American Journal of Medical Genetics"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0347|cit347","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0029-7844(96)00524-8","article-title":"Race-ethnicity-specific variation in multiple-marker biochemical screening: Alpha-fetoprotein, hCG, and estriol","volume":"89","author":"Brien","year":"1997","journal-title":"Obstetrics and Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0348|cit348","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/01.AOG.0000148848.49752.37","article-title":"The association between fetal nasal bone hypoplasia and aneuploidy","volume":"104","author":"Odibo","year":"2004","journal-title":"Obstetrics & Gynecology"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0349|cit349","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1058::AID-PD685>3.0.CO;2-S","article-title":"Maternal serum superoxide dismutase (SOD): a possible marker for screening Down syndrome affected pregnancies.[see comment]","volume":"19","author":"Ognibene","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0350|cit350","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0028-2243(89)90058-0","article-title":"Maternal serum AFP levels in the first trimester of pregnancy","volume":"30","author":"Olajide","year":"1989","journal-title":"European Journal of Obstetrics, Gynecology, & Reproductive Biology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0351|cit351","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/(SICI)1097-0223(199608)16:8<713::AID-PD933>3.0.CO;2-X","article-title":"Triple marker screening in native Japanese women","volume":"16","author":"Onda","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0352|cit352","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/(SICI)1097-0223(199809)18:9<956::AID-PD370>3.0.CO;2-R","article-title":"Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan","volume":"18","author":"Onda","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0353|cit353","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1447-0756.2000.tb01355.x","article-title":"Triple marker screening for trisomy 21, trisomy 18 and open neural tube defects in singleton pregnancies of native Japanese pregnant women","volume":"26","author":"Onda","year":"2000","journal-title":"Journal of Obstetrics & Gynaecology Research"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0354|cit354","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/pd.390","article-title":"First trimester screening with free \u00df-hCG, PAPP-A and nuchal translucency in pregnancies conceived with assisted reproduction","volume":"22","author":"Orlandi","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0355|cit355","first-page":"99","article-title":"Plasma protein \"A\" and chorionic gonadotropin at first trimester pregnancy","volume":"6","author":"P\u00e1ez","year":"2004","journal-title":"Informe Medico"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0356|cit356","first-page":"411","article-title":"Prenatal diagnosis using the triple test","volume":"50","author":"Palka","year":"1998","journal-title":"Minerva Ginecologica"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0357|cit357","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0002-9378(89)80031-6","article-title":"Combining maternal serum alpha-fetoprotein measurements and age to screen for Down syndrome in pregnant women under age 35","volume":"160","author":"Palomaki","year":"1989","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0358|cit358","first-page":"675","article-title":"Cigarette smoking and levels of maternal serum alpha-fetoprotein, unconjugated estriol, and hCG: Impact on Down syndrome screening","volume":"81","author":"Palomaki","year":"1993","journal-title":"Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0359|cit359","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/pd.1970140112","article-title":"Human chorionic gonadotropin and unconjugated oestriol measurements in insulin-dependent diabetic pregnant women being screened for fetal Down syndrome","volume":"14","author":"Palomaki","year":"1994","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0360|cit360","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/096914139600300105","article-title":"Can reliable Down's syndrome detection rates be determined from prenatal screening intervention trials?","volume":"3","author":"Palomaki","year":"1996","journal-title":"Journal of Medical Screening"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0361|cit361","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1373\/clinchem.2005.050567","article-title":"Maternal serum invasive trophoblast antigen and first-trimester Down syndrome screening","volume":"51","author":"Palomaki","year":"2005","journal-title":"Clinical Chemistry"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0362|cit362","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0020-7292(01)00482-9","article-title":"First trimester Down Syndrome screening by nuchal translucency in a Thai population","volume":"75","author":"Panburana","year":"2001","journal-title":"International Journal of Gynaecology & Obstetrics"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0363|cit363","first-page":"420","article-title":"First-trimester fetal nuchal translucency thickness and risk for trisomies","volume":"84","author":"Pandya","year":"1994","journal-title":"Obstetrics & Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0364|cit364","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00001703-199504000-00004","article-title":"First trimester fetal nuchal translucency","volume":"7","author":"Pandya","year":"1995","journal-title":"Current Opinion in Obstetrics and Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0365|cit365","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.0960-7692.2001.00547.x","article-title":"Measurement of fetal nuchal translucency thickness by three-dimensional ultrasound","volume":"18","author":"Paul","year":"2001","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0366|cit366","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/uog.1885","article-title":"Assessment of the gap between the fetal nasal bones at 11 to 13 + 6 weeks of gestation by three-dimensional ultrasound","volume":"25","author":"Peralta","year":"2005","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"3-4","key":"10.1002\/14651858.CD009925-BIB0367|cit367","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1017\/S0001566000000179","article-title":"Analysis of triple test results in 27 cases of twin pregnancies","volume":"47","author":"Perenc","year":"1998","journal-title":"Acta Geneticae Medicae et Gemellologiae"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0368|cit368","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/humrep\/17.3.794","article-title":"Maternal serum (\u00df)-HCG and (alpha)-fetoprotein concentrations in singleton pregnancies following assisted reproduction","volume":"17","author":"Perheentupa","year":"2002","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0369|cit369","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s005990050040","article-title":"Influence of smoking habits on Down's syndrome risk evaluation at mid-trimester through biochemical screening","volume":"28","author":"Perona","year":"1998","journal-title":"International Journal of Clinical & Laboratory Research"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0370|cit370","first-page":"399","article-title":"[Significance of nuchal edema in fetuses of pregnant women under 35 years of age]. [Hungarian]","volume":"141","author":"Petervari","year":"2000","journal-title":"Orvosi Hetilap"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0371|cit371","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/0002-9378(89)90657-1","article-title":"Prenatal screening for Down syndrome with maternal serum human chorionic gonadotropin levels.[see comment]","volume":"161","author":"Petrocik","year":"1989","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0372|cit372","first-page":"353","article-title":"Maternal serum screening for fetal Down syndrome in women less than 35 years of age using alpha-fetoprotein, hCG, and unconjugated estriol: a prospective 2-year study","volume":"80","author":"Phillips","year":"1992","journal-title":"Obstetrics & Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0373|cit373","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0932-8610(12)80224-6","article-title":"Maternal serum screening for fetal Down syndrome using alpha- fetoprotein, human chorionic gonadotrophin, and unconjugated estriol in adolescents","volume":"6","author":"Phillips","year":"1993","journal-title":"Adolescent and Pediatric Gynecology"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0374|cit374","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.7863\/jum.2003.22.11.1185","article-title":"Combined sonographic and biochemical markers for Down syndrome screening","volume":"22","author":"Pinette","year":"2003","journal-title":"Journal of Ultrasound in Medicine"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0375|cit375","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/01.AOG.0000139832.79658.b9","article-title":"Sequential pathways of testing after first-trimester screening for trisomy 21","volume":"104","author":"Platt","year":"2004","journal-title":"Obstetrics and Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0376|cit376","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1515\/jpme.1995.23.4.283","article-title":"First trimester diagnosis of cystic hygromata using transvaginal ultrasound and cytogenetic evaluation","volume":"23","author":"Podobnik","year":"1995","journal-title":"Journal of Perinatal Medicine"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0377|cit377","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/pd.432","article-title":"Agreement between predicted risk and prevalence of Down syndrome in first trimester nuchal translucency screening","volume":"22","author":"Prefumo","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0378|cit378","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1046\/j.1471-0528.2003.00025.x-i1","article-title":"Maternal ethnic origin and fetal nasal bones at 11-14 weeks of gestation","volume":"111","author":"Prefumo","year":"2004","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology."},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0379|cit379","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1093\/humrep\/13.6.1706","article-title":"First trimester maternal serum concentrations of fetal antigen 2 in normal pregnancies and those affected by trisomy 21","volume":"13","author":"Price","year":"1998","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0380|cit380","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/(SICI)1097-0223(200003)20:3<221::AID-PD787>3.0.CO;2-S","article-title":"Maternal midtrimester serum AFP and free \u00df-hCG levels in in vitro fertilization twin pregnancies","volume":"20","author":"Raty","year":"2000","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0381|cit381","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/humrep\/17.2.481","article-title":"Serum free (\u00df)-HCG and alpha-fetoprotein levels in IVF, ICSI and frozen embryo transfer pregnancies in maternal mid-trimester serum screening for Down's syndrome","volume":"17","author":"R\u00e4ty","year":"2002","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0382|cit382","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/uog.952","article-title":"Assessment of the fetal nasal bone at 11-14 weeks of gestation by three-dimensional ultrasound","volume":"23","author":"Rembouskos","year":"2004","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0383|cit383","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-2007-1018865","article-title":"Human chorionic gonadotropin","volume":"10","author":"Ren","year":"1992","journal-title":"Seminars in Reproductive Endocrinology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0384|cit384","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/humrep\/13.3.744","article-title":"Second trimester maternal dimeric inhibin-A in the multiple-marker screening test for Down's syndrome","volume":"13","author":"Renier","year":"1998","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0385|cit385","first-page":"104","article-title":"The role of ultrasound in screening for Down syndrome","volume":"26","author":"Resta","year":"1990","journal-title":"Birth Defects: Original Article Series"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0386|cit386","doi-asserted-by":"crossref","first-page":"101","DOI":"10.7863\/jum.1997.16.2.101","article-title":"First trimester isolated fetal nuchal lucency: significance and outcome","volume":"16","author":"Reynders","year":"1997","journal-title":"Journal of Ultrasound in Medicine"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0387|cit387","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/000456329002700506","article-title":"The mathematical basis of multivariate risk screening: with special reference to screening for Down's syndrome associated pregnancy","volume":"27","author":"Reynolds","year":"1989","journal-title":"Annals of Clinical Biochemistry"},{"issue":"1-2","key":"10.1002\/14651858.CD009925-BIB0388|cit388","first-page":"49","article-title":"Estimation of Down's syndrome risks in the first trimester of pregnancy: Experience of testing with PAPP-A, total hCG and free \u00df- hCG levels in maternal blood samples in a German population","volume":"45","author":"Reynolds","year":"1999","journal-title":"Clinical Laboratory"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0389|cit389","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/(SICI)1097-0223(199601)16:1<35::AID-PD805>3.0.CO;2-9","article-title":"Maternal serum screening for fetal Down syndrome in IVF pregnancies","volume":"16","author":"Ribbert","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0390|cit390","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/pd.1116","article-title":"Second-trimester maternal serum screening for Down syndrome in in vitro fertilization pregnancies","volume":"25","author":"Rice","year":"2005","journal-title":"Prenatal Diagnosis"},{"issue":"2-3","key":"10.1002\/14651858.CD009925-BIB0391|cit391","first-page":"135","article-title":"Efficiency of maternal serum hCG AFP and free estriol in the identification of trisomy 21 and other complications of pregnancy","volume":"62","author":"Rich","year":"1991","journal-title":"Journal of the Alabama Academy of Science"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0392|cit392","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1471-0528.1995.tb11289.x","article-title":"First trimester fetal nuchal translucency: problems with screening the general population. 1","volume":"102","author":"Roberts","year":"1995","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0393|cit393","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5694\/j.1326-5377.1991.tb142124.x","article-title":"Maternal serum screening for neural tube defects and Down's syndrome.[see comment]","volume":"155","author":"Robertson","year":"1991","journal-title":"Medical Journal of Australia"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0394|cit394","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/pd.648","article-title":"Combined first- and second-trimester screening for Down syndrome: an evaluation of proMBP as a marker","volume":"23","author":"Rode","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0395|cit395","first-page":"332","article-title":"Combined first trimester screening for Down's syndrome is superior to quadruple test","volume":"66","author":"Ronge","year":"2006","journal-title":"Geburtshilfe und Frauenheilkunde"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0396|cit396","first-page":"55","article-title":"Multiple marker screening for women 35 and older","volume":"40","author":"Rose","year":"1995","journal-title":"Contemporary OB\/GYN"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0397|cit397","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0889-8545(05)70288-6","article-title":"Maternal serum screening for fetal genetic disorders","volume":"24","author":"Ross","year":"1997","journal-title":"Obstetrics & Gynecology Clinics of North America"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0398|cit398","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0002-9378(96)70435-0","article-title":"Nicked free \u00df-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening","volume":"174","author":"Rotmensch","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0399|cit399","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1023\/A:1022585326896","article-title":"Midtrimester maternal serum screening after multifetal pregnancy reduction in pregnancies conceived by in vitro fertilization","volume":"16","author":"Rotmensch","year":"1999","journal-title":"Journal of Assisted Reproduction and Genetics"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0400|cit400","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.ajog.2006.02.046","article-title":"Screening for Down syndrome using first-trimester combined screening followed by second-trimester ultrasound examination in an unselected population","volume":"195","author":"Rozenberg","year":"2006","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0401|cit401","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/pd.440","article-title":"Influence of maternal smoking on the birth prevalence of Down syndrome and on second trimester screening performance","volume":"22","author":"Rudnicka","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0402|cit402","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/pd.1970120404","article-title":"Improved performance in a prenatal screening programme for Down's syndrome incorporating serum-free hCG subunit analyses","volume":"12","author":"Ryall","year":"1992","journal-title":"Prenatal Diagnosis"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0403|cit403","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/pd.108","article-title":"Karyotypes found in the population declared at increased risk of Down syndrome following maternal serum screening","volume":"21","author":"Ryall","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0404|cit404","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/14722240208500490","article-title":"Aneuploidy screening: Ultrasound versus biochemistry","volume":"2","author":"Sabri\u00e1","year":"2002","journal-title":"Ultrasound Review of Obstetrics and Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0405|cit405","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/uog.903","article-title":"Ear length in trisomy 21 fetuses at 11-14 weeks of gestation","volume":"22","author":"Sacchini","year":"2003","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0406|cit406","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0002-9378(97)70287-4","article-title":"Maternal serum analyte levels in pregnancies with fetal Down syndrome resulting from translocations","volume":"177","author":"Saller","year":"1997","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0407|cit407","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1046\/j.0960-7692.2001.00582.x","article-title":"Relationship between nuchal translucency at 11-14 weeks and nuchal fold at 20-24 weeks of gestation","volume":"18","author":"Salomon","year":"2001","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0408|cit408","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3109\/00016349709024358","article-title":"Maternal serum screening for Down's syndrome on population basis","volume":"76","author":"Salonen","year":"1997","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0409|cit409","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/uog.1917","article-title":"Screening for Down syndrome based on maternal age or fetal nuchal translucency: a randomized controlled trial in 39,572 pregnancies","volume":"25","author":"Saltvedt","year":"2005","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0410|cit410","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1471-0528.1996.tb09630.x","article-title":"Screening for Down's syndrome: experience in an inner city health district","volume":"103","author":"Saridogan","year":"1996","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0411|cit411","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/pd.1970130613","article-title":"Ultrasound screening for chromosomal anomalies in the first trimester of pregnancy","volume":"13","author":"Savoldelli","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0412|cit412","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/pd.1487","article-title":"The \"Consecutive Combined Test\"--using double test from week 8 + 0 and nuchal translucency scan, for first trimester screening for Down syndrome","volume":"26","author":"Schiott","year":"2006","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0413|cit413","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1097-0223(199803)18:3<281::AID-PD306>3.0.CO;2-6","article-title":"The distribution of nuchal translucency at 10-13 weeks of pregnancy","volume":"18","author":"Schuchter","year":"1998","journal-title":"Prenatal Diagnosi"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0414|cit414","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1479-828X.1995.tb01860.x","article-title":"Maternal serum screening and routine 18-week ultrasound in the detection of all chromosomal abnormalities","volume":"35","author":"Scott","year":"1995","journal-title":"Australian & New Zealand Journal of Obstetrics & Gynaecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0415|cit415","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00013644-199000820-00003","article-title":"Ultrasound and maternal serum alpha-fetoprotein screening: A complementary relationship","volume":"8","author":"Seeds","year":"1990","journal-title":"Ultrasound Quarterly"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0416|cit416","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000292328","article-title":"Measurement of urinary free \u00df-human chorionic gonadotropin by immunoradiometric assay","volume":"40","author":"Seki","year":"1995","journal-title":"Gynecologic and Obstetric Investigation"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0417|cit417","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/pd.564","article-title":"Midtrimester triple-test levels in women with chronic hypertension and altered renal function","volume":"23","author":"Shenhav","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0418|cit418","first-page":"185","article-title":"[Screening for chromosomal anomalies with maternal serum alpha-fetoprotein]. [Japanese]","volume":"41","author":"Shintaku","year":"1989","journal-title":"Nippon Sanka Fujinka Gakkai Zasshi - Acta Obstetrica et Gynaecologica Japonica"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0419|cit419","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/pd.650","article-title":"Mid-gestation Down syndrome screening test and pregnancy outcome among unstimulated assisted-conception pregnancies","volume":"23","author":"Shulman","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0420|cit420","first-page":"289","article-title":"[Markers for trisomy 21][French]","volume":"27","author":"Simon-Bouy","year":"1999","journal-title":"Fertilite Contraception Sexualite"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0421|cit421","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0002-9378(86)90285-1","article-title":"Maternal serum alpha-fetoprotein screening: low and high values for detection of genetic abnormalities","volume":"155","author":"Simpson","year":"1986","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0422|cit422","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/875647939000600602","article-title":"Maternal serum alpha-fetoprotein screening and the role of ultrasound","volume":"6","author":"Smith","year":"1990","journal-title":"Journal of Diagnostic Medical Sonography"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0423|cit423","first-page":"176","article-title":"Does the addition of unconjugated estriol in maternal serum screening improve the detection of trisomy 21? A meta-analysis","volume":"10","author":"Smith","year":"1996","journal-title":"Clinical Laboratory Management Review"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0424|cit424","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1471-0528.1999.tb08232.x","article-title":"A six year study of the antenatal detection of fetal abnormality in six Scottish health boards","volume":"106","author":"Smith","year":"1999","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0425|cit425","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1001\/jama.285.8.1044","article-title":"Second-trimester ultrasound to detect fetuses with Down syndrome: a meta-analysis.[see comment]","volume":"285","author":"Smith-Bindman","year":"2001","journal-title":"JAMA"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0426|cit426","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1067\/S0002-9378(03)00721-X","article-title":"Prenatal screening for Down syndrome in England and Wales and population-based birth outcomes","volume":"187","author":"Smith-Bindman","year":"2003","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0427|cit427","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1159\/000264259","article-title":"Maternal age and gestational age-specific risk for chromosomal defects","volume":"10","author":"Snijders","year":"1995","journal-title":"Fetal Diagnosis and Therapy"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0428|cit428","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1469-0705.1999.13030167.x","article-title":"Maternal age- and gestation-specific risk for trisomy 21","volume":"13","author":"Snijders","year":"1999","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0429|cit429","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000091353","article-title":"Screening for trisomy 21 with maternal age, fetal nuchal translucency and maternal serum biochemistry at 11-14 weeks: a regional experience from Germany","volume":"21","author":"Soergel","year":"2006","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0430|cit430","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0002-9378(98)70199-1","article-title":"Age-specific variation in aneuploidy incidence among biochemical screening programs","volume":"179","author":"Sokol","year":"1998","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0431|cit431","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/uog.182","article-title":"Nasal bone evaluation with ultrasonography: A marker for fetal aneuploidy","volume":"22","author":"Sonek","year":"2003","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"issue":"6486","key":"10.1002\/14651858.CD009925-BIB0432|cit432","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1136\/bmj.290.6486.1940","article-title":"Screening for Down's syndrome using serum alpha fetoprotein: a retrospective study indicating caution","volume":"290","author":"Spencer","year":"1985","journal-title":"British Medical Journal Clinical Research Education"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0433|cit433","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/clinchem\/37.6.809","article-title":"Evaluation of an assay of the free \u00df-subunit of choriogonadotropin and its potential value in screening for Down's syndrome","volume":"37","author":"Spencer","year":"1991","journal-title":"Clinical Chemistry"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0434|cit434","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/000456329102800318","article-title":"Maternal serum CA125 is not a second trimester marker for Down's syndrome","volume":"28","author":"Spencer","year":"1991","journal-title":"Annals of Clinical Biochemistry"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0435|cit435","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/000456329202900504","article-title":"Free \u00df human choriogonadotropin in Down's syndrome screening: a multicentre study of its role compared with other biochemical markers.[see comment]","volume":"29","author":"Spencer","year":"1992","journal-title":"Annals of Clinical Biochemistry"},{"issue":"6907","key":"10.1002\/14651858.CD009925-BIB0436|cit436","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/bmj.307.6907.764","article-title":"Prospective study of prenatal screening for Down's syndrome with free \u00df human chorionic gonadotrophin.[see comment]","volume":"307","author":"Spencer","year":"1993","journal-title":"BMJ"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0437|cit437","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/clinchem\/39.6.1064","article-title":"Stability of intact chorionic gonadotropin (hCG) in serum, liquid whole blood, and dried whole-blood filter-paper spots: impact on screening for Down syndrome by measurement of free \u00df-hCG subunit","volume":"39","author":"Spencer","year":"1993","journal-title":"Clinical Chemistry"},{"issue":"Pt 2","key":"10.1002\/14651858.CD009925-BIB0438|cit438","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/000456329303000226","article-title":"Elevated levels of maternal serum inhibin immunoreactivity in second trimester pregnancies affected by Down's syndrome","volume":"30","author":"Spencer","year":"1993","journal-title":"Annals of Clinical Biochemistry"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0439|cit439","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/000456329303000408","article-title":"Dual analyte immunoassay in neural tube defect and Down's syndrome screening: results of a multicentre clinical trial","volume":"30","author":"Spencer","year":"1993","journal-title":"Annals of Clinical Biochemistry"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0440|cit440","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0002-9378(12)90901-1","article-title":"Free alpha-subunit of human chorionic gonadotropin in Down syndrome","volume":"168","author":"Spencer","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0441|cit441","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/pd.1970150119","article-title":"The influence of gravidity on Down's syndrome screening with free \u00df hCG","volume":"15","author":"Spencer","year":"1995","journal-title":"Prenatal Diagnosis"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0442|cit442","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1101::AID-PD5>3.0.CO;2-7","article-title":"Second-trimester dimeric inhibin-A in Down's syndrome screening","volume":"16","author":"Spencer","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0443|cit443","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/(SICI)1097-0223(199706)17:6<525::AID-PD105>3.0.CO;2-I","article-title":"First-trimester urine free \u00df hCG, \u00df core, and total oestriol in pregnancies affected by Down's syndrome: implications for first-trimester screening with nuchal translucency and serum free \u00df hCG","volume":"17","author":"Spencer","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0444|cit444","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1097-0223(199803)18:3<225::AID-PD239>3.0.CO;2-B","article-title":"The influence of smoking on maternal serum AFP and free \u00df hCG levels and the impact on screening for Down syndrome","volume":"18","author":"Spencer","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0445|cit445","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1093\/clinchem\/44.11.2362","article-title":"Is prostate-specific antigen a marker for pregnancies affected by Down syndrome?","volume":"44","author":"Spencer","year":"1998","journal-title":"Clinical Chemistry"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0446|cit446","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/j.1471-0528.1999.tb08183.x","article-title":"Second trimester prenatal screening for Down's syndrome using alpha-fetoprotein and free \u00df hCG: a seven year review","volume":"106","author":"Spencer","year":"1999","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0447|cit447","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/000456329903600115","article-title":"Accuracy of Down's syndrome risks produced in a prenatal screening program","volume":"36","author":"Spencer","year":"1999","journal-title":"Annals of Clinical Biochemistry"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0448|cit448","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-0223(200004)20:4<311::AID-PD809>3.0.CO;2-P","article-title":"Is maternal serum total hCG a marker of trisomy 21 in the first trimester of pregnancy?","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenatal Diagnosis."},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0449|cit449","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1097-0223(200002)20:2<91::AID-PD759>3.0.CO;2-X","article-title":"Screening for trisomy 21 in twin pregnancies in the first trimester using free \u00df-hCG and PAPP-A, combined with fetal nuchal translucency thickness","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenatal Diagnosis."},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0450|cit450","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1065::AID-PD695>3.0.CO;2-R","article-title":"The influence of smoking on maternal serum PAPP-A and free \u00df hCG levels in the first trimester of pregnancy","volume":"19","author":"Spencer","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0451|cit451","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/1097-0223(200010)20:10<792::AID-PD914>3.0.CO;2-5","article-title":"The influence of parity and gravidity on first trimester markers of chromosomal abnormality","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenatal Diagnosis"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0452|cit452","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/1097-0223(200008)20:8<648::AID-PD869>3.0.CO;2-L","article-title":"The influence of fetal sex in screening for Down syndrome in the second trimester using AFP and free \u00df-hCG","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0453|cit453","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/1097-0223(200006)20:6<491::AID-PD844>3.0.CO;2-3","article-title":"The influence of ethnic origin on first trimester biochemical markers of chromosomal abnormalities","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenatal Diagnosis"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0454|cit454","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<390::AID-PD824>3.0.CO;2-B","article-title":"Maternal serum free \u00df-hCG and PAPP-A in fetal sex chromosome defects in the first trimester","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenatal Diagnosis."},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0455|cit455","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/1097-0223(200008)20:8<652::AID-PD882>3.0.CO;2-6","article-title":"Second-trimester prenatal screening for Down syndrome and the relationship of maternal serum biochemical markers to pregnancy complications with adverse outcome","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenatal Diagnosis."},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0456|cit456","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/1097-0223(200008)20:8<673::AID-PD880>3.0.CO;2-5","article-title":"The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free \u00df-hCG and PAPP-A at 10-14 weeks of gestation","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenatal Diagnosis."},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0457|cit457","first-page":"1043","article-title":"Age related detection and false positive rates when screening for Down's syndrome in the first trimester using fetal nuchal translucency and maternal serum free \u00dfhCG and PAPP-A","volume":"108","author":"Spencer","year":"2001","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0458|cit458","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/pd.148","article-title":"First trimester maternal serum placenta growth factor (PIGF)concentrations in pregnancies with fetal trisomy 21 or trisomy 18","volume":"21","author":"Spencer","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0459|cit459","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/pd.98","article-title":"Maternal serum levels of dimeric Inhibin A in pregnancies affected by trisomy 21 in the first trimester","volume":"21","author":"Spencer","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0460|cit460","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/pd.53","article-title":"Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies","volume":"21","author":"Spencer","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0461|cit461","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/pd.152","article-title":"Screening for trisomy 21 in twin pregnancies in the first trimester: does chorionicity impact on maternal serum free \u00df-hCG or PAPP-A levels?","volume":"21","author":"Spencer","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0462|cit462","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/pd.420","article-title":"A first trimester trisomy 13\/trisomy 18 risk algorithm combining fetal nuchal translucency thickness, maternal serum free \u00df-hCG and PAPP-A","volume":"22","author":"Spencer","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0463|cit463","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/pd.312","article-title":"Accuracy of Down syndrome risks produced in a first-trimester screening programme incorporating fetal nuchal translucency thickness and maternal serum biochemistry","volume":"22","author":"Spencer","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0464|cit464","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/pd.441","article-title":"Screening for chromosomal anomalies in the first trimester: does repeat maternal serum screening improve detection rates?","volume":"22","author":"Spencer","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0465|cit465","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/000456320203900604","article-title":"Temporal changes in maternal serum biochemical markers of trisomy 21 across the first and second trimester of pregnancy","volume":"39","author":"Spencer","year":"2002","journal-title":"Annals of Clinical Biochemistry"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0466|cit466","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1258\/000456303321610501","article-title":"The effect of temporal variation in biochemical markers of trisomy 21 across the first and second trimesters of pregnancy on the estimation of individual patient-specific risks and detection rates for Down's syndrome","volume":"40","author":"Spencer","year":"2003","journal-title":"Annals of Clinical Biochemistry"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0467|cit467","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1258\/000456303763046102","article-title":"The influence of different sample collection types on the levels of markers used for Down's syndrome screening as measured by the Kryptor Immunosassay system","volume":"40","author":"Spencer","year":"2003","journal-title":"Annals of Clinical Biochemistry"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0468|cit468","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/pd.708","article-title":"Maternal weight correction of maternal serum PAPP-A and free \u00df-hCG MoM when screening for trisomy 21 in the first trimester of pregnancy","volume":"23","author":"Spencer","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0469|cit469","first-page":"279","article-title":"Screening for trisomy 21 in twins using first trimester ultrasound and maternal serum biochemistry in a one-stop clinic: a review of three years experience","volume":"110","author":"Spencer","year":"2003","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0470|cit470","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/pd.819","article-title":"The impact of correcting for smoking status when screening for chromosomal anomalies using maternal serum biochemistry and fetal nuchal translucency thickness in the first trimester of pregnancy","volume":"24","author":"Spencer","year":"2004","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0471|cit471","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/pd.1229","article-title":"The influence of maternal insulin-dependent diabetes on fetal nuchal translucency thickness and first-trimester maternal serum biochemical markers of aneuploidy","volume":"25","author":"Spencer","year":"2005","journal-title":"Prenatal Diagnosis"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0472|cit472","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/pd.1153","article-title":"Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first trimester: a study of Oriental, Asian and Afro-Caribbean populations","volume":"25","author":"Spencer","year":"2005","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0473|cit473","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1258\/0004563053026880","article-title":"First trimester maternal serum screening for Down's syndrome: an evaluation of the DPC Immulite 2000 free \u00df-hCG and pregnancy-associated plasma protein-A assays.[see comment]","volume":"42","author":"Spencer","year":"2005","journal-title":"Annals of Clinical Biochemistry"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0474|cit474","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/(SICI)1097-0223(199904)19:4<337::AID-PD553>3.0.CO;2-4","article-title":"Risk of abnormal triple screen for Down syndrome is significantly higher in women with female fetuses","volume":"19","author":"Spong","year":"1999","journal-title":"Prenatal Diagnosis."},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0475|cit475","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/875647939801400603","article-title":"The use of nuchal lucency as a screening tool in first trimester sonography","volume":"14","author":"Stevens","year":"1998","journal-title":"Journal of Diagnostic Medical Sonography"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0476|cit476","first-page":"25","article-title":"A new approach of prenatal prevention of constitutional disabilities - the study of markers of maternal serum","volume":"23","author":"Stoll","year":"1992","journal-title":"Journal de Medecine de Strasbourg"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0477|cit477","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pd.218","article-title":"Raised maternal serum placenta growth factor concentration during the second trimester is associated with Down syndrome","volume":"22","author":"Su","year":"2002","journal-title":"Prenatal Diagnosis"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0478|cit478","first-page":"344","article-title":"Ultrasonography of the fetal neck in the first and second trimesters. Part 2. Anomalies of the posterior nuchal region","volume":"46","author":"Suchet","year":"1995","journal-title":"Canadian Association of Radiologists Journal"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0479|cit479","first-page":"20","article-title":"Down syndrome screening in women under 35 with maternal serum hCG","volume":"76","author":"Suchy","year":"1990","journal-title":"Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0480|cit480","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/096914130301000302","article-title":"Maternal serum screening in Ontario using the triple marker test","volume":"10","author":"Summers","year":"2003","journal-title":"Journal of Medical Screening"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0481|cit481","first-page":"1301","article-title":"The implications of a false positive second-trimester serum screen for Down syndrome","volume":"101","author":"Summers","year":"2003","journal-title":"Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0482|cit482","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000087206","article-title":"Variability of nuchal translucency measurement: a multicenter study in Thailand","volume":"60","author":"Suntharasaj","year":"2005","journal-title":"Gynecologic & Obstetric Investigation"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0483|cit483","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/pd.836","article-title":"Sialic acid-deficient invasive trophoblast antigen (sd-ITA): a new urinary variant for gestational Down syndrome screening","volume":"24","author":"Sutton","year":"2004","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0484|cit484","first-page":"37","article-title":"Screening for trisomy 21 in the first trimester by measurement of serum PAPP-A and free \u00df-hCG","volume":"50","author":"Suzuki","year":"1998","journal-title":"Acta Obstetrica et Gynaecologica Japonica"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0485|cit485","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1471-0528.1987.tb03167.x","article-title":"Screening for Down's syndrome using an iso-risk curve based on maternal age and serum alpha-fetoprotein level","volume":"94","author":"Tabor","year":"1987","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0486|cit486","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/(SICI)1096-8628(19990716)85:2<123::AID-AJMG5>3.0.CO;2-M","article-title":"Predictive value of the triple screening test for the phenotype of Down syndrome","volume":"85","author":"Tanski","year":"1999","journal-title":"American Journal of Medical Genetics"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0487|cit487","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1469-0705.1998.12020112.x","article-title":"Influence of ethnic origin on nuchal translucency screening for Down's syndrome","volume":"12","author":"Thilaganathan","year":"1998","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0488|cit488","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1046\/j.1469-0705.1999.13040229.x","article-title":"First-trimester nuchal translucency and maternal serum biochemical screening for Down's syndrome: A happy union?","volume":"13","author":"Thilaganathan","year":"1999","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0489|cit489","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000047999","article-title":"The influence of smoking and parity on serum markers for Down's syndrome screening","volume":"17","author":"Tislaric","year":"2002","journal-title":"Fetal Diagnosis & Therapy"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0490|cit490","first-page":"123","article-title":"[Biochemical and ultrasonic screening of chromosomal aneuploidies in the second trimester of pregnancy]. [Hungarian]","volume":"138","author":"Torok","year":"1997","journal-title":"Orvosi Hetilap"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0491|cit491","first-page":"319","article-title":"Combined measurement of fetal nuchal translucency, maternal serum free \u00df-hCG, and pregnancy-associated plasma protein A for first-trimester Down's syndrome screening","volume":"100","author":"Tsai","year":"2001","journal-title":"Journal of the Formosan Medical Association"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0492|cit492","first-page":"169","article-title":"Maternal serum screening of fetal chromosomal abnormalities by AFP, UE3, hCG and free-\u00df hCG. Prospective and retrospective results","volume":"48","author":"Valerio","year":"1996","journal-title":"Minerva Ginecologica"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0493|cit493","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/pd.1970121213","article-title":"Second-trimester cancer antigen 125 and Down's syndrome.[see comment]","volume":"12","author":"Blerk","year":"1992","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0494|cit494","first-page":"162","article-title":"Combined first trimester screening for trisomy 21: Lack of agreement between risk calculation methods","volume":"34","author":"Van","year":"2006","journal-title":"Journal of Perinatal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0495|cit495","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1471-0528.1991.tb10351.x","article-title":"First trimester CA 125 and Down's syndrome","volume":"98","author":"Lith","year":"1991","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0496|cit496","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/pd.1970131207","article-title":"Maternal serum CA 125 levels in pregnancies with chromosomally-normal and -abnormal fetuses. Dutch Working Party on Prenatal Diagnosis","volume":"13","author":"Van","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"5 Pt 1","key":"10.1002\/14651858.CD009925-BIB0497|cit497","first-page":"661","article-title":"First-trimester maternal serum immunoreactive inhibin in chromosomally normal and abnormal pregnancies. Dutch Working Party on Prenatal Diagnosis","volume":"83","author":"Van","year":"1994","journal-title":"Obstetrics and Gynecology"},{"issue":"20","key":"10.1002\/14651858.CD009925-BIB0498|cit498","first-page":"1232","article-title":"[Low maternal serum alpha-fetoprotein concentration and Down syndrome]. [Hungarian]","volume":"127","author":"Veress","year":"1986","journal-title":"Orvosi Hetilap"},{"issue":"31","key":"10.1002\/14651858.CD009925-BIB0499|cit499","first-page":"1677","article-title":"[Prenatal screening for Down's syndrome by measuring the AFP concentration in the maternal serum]. [Hungarian]","volume":"129","author":"Veress","year":"1988","journal-title":"Orvosi Hetilap"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0500|cit500","first-page":"905","article-title":"Absent nasal bone in the prenatal detection of fetuses with trisomy 21 in a high-risk population","volume":"101","author":"Vintzileos","year":"2003","journal-title":"Obstetrics & Gynecology"},{"issue":"6653","key":"10.1002\/14651858.CD009925-BIB0501|cit501","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1136\/bmj.297.6653.883","article-title":"Maternal serum screening for Down's syndrome in early pregnancy","volume":"297","author":"Wald","year":"1988","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0502|cit502","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1471-0528.1988.tb06602.x","article-title":"Maternal serum unconjugated oestriol as an antenatal screening test for Down's syndrome","volume":"95","author":"Wald","year":"1988","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0503|cit503","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1471-0528.1991.tb13513.x","article-title":"Maternal serum unconjugated oestriol and human chorionic gonadotrophin levels in twin pregnancies: implications for screening for Down's syndrome","volume":"98","author":"Wald","year":"1991","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"6850","key":"10.1002\/14651858.CD009925-BIB0504|cit504","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/bmj.305.6850.391","article-title":"Antenatal maternal serum screening for Down's syndrome: results of a demonstration project.[see comment]","volume":"305","author":"Wald","year":"1992","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0505|cit505","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1471-0528.1992.tb14392.x","article-title":"Maternal serum unconjugated oestriol and human chorionic gonadotrophin levels in pregnancies with insulin-dependent diabetes: implications for screening for Down's syndrome","volume":"99","author":"Wald","year":"1992","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0506|cit506","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1471-0528.1992.tb14474.x","article-title":"Maternal serum screening for Down's syndrome: the effect of routine ultrasound scan determination of gestational age and adjustment for maternal weight.[see comment]","volume":"99","author":"Wald","year":"1992","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0507|cit507","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1471-0528.1993.tb15307.x","article-title":"The use of free \u00df-hCG in antenatal screening for Down's syndrome.[see comment]","volume":"100","author":"Wald","year":"1993","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0508|cit508","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/pd.1970140811","article-title":"Maternal serum free alpha-human chorionic gonadotrophin levels in twin pregnancies: implications for screening for Down's syndrome","volume":"14","author":"Wald","year":"1994","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0509|cit509","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/096914139400100211","article-title":"Choice of serum markers in antenatal screening for Down's syndrome","volume":"1","author":"Wald","year":"1994","journal-title":"Journal of Medical Screening"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0510|cit510","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/(SICI)1097-0223(199608)16:8<699::AID-PD919>3.0.CO;2-P","article-title":"Serum markers for Down's syndrome in relation to number of previous births and maternal age","volume":"16","author":"Wald","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0511|cit511","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1471-0528.1996.tb09765.x","article-title":"Serum screening for Down's syndrome between 8 and 14 weeks of pregnancy. International Prenatal Screening Research Group.[see comment]","volume":"103","author":"Wald","year":"1996","journal-title":"British Journal of Obstetrics & Gynaecology."},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0512|cit512","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/(SICI)1097-0223(199610)16:10<923::AID-PD970>3.0.CO;2-A","article-title":"Maternal serum inhibin-A in pregnancies with insulin-dependent diabetes mellitus: implications for screening for Down's syndrome","volume":"16","author":"Wald","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0513|cit513","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/(SICI)1097-0223(199602)16:2<143::AID-PD825>3.0.CO;2-F","article-title":"Prenatal screening for Down's syndrome using inhibin-A as a serum marker.","volume":"16","author":"Wald","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0514|cit514","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/(SICI)1097-0223(199709)17:9<821::AID-PD154>3.0.CO;2-5","article-title":"Combining ultrasound and biochemistry in first-trimester screening for Down's syndrome.[see comment]","volume":"17","author":"Wald","year":"1997","journal-title":"Prenatal Diagnosis"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0515|cit515","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/(SICI)1097-0223(199803)18:3<291::AID-PD244>3.0.CO;2-8","article-title":"Screening for Down syndrome at 14 weeks of pregnancy","volume":"18","author":"Wald","year":"1998","journal-title":"Prenatal Diagnosis"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0516|cit516","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/(SICI)1097-0223(199907)19:7<674::AID-PD590>3.0.CO;2-M","article-title":"Maternal serum prostate-specific antigen and Down syndrome in the first and second trimesters of pregnancy","volume":"19","author":"Wald","year":"1999","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0517|cit517","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/(SICI)1097-0223(199906)19:6<517::AID-PD591>3.0.CO;2-2","article-title":"SP1 in pregnancies with Down syndrome in the first trimester of pregnancy","volume":"19","author":"Wald","year":"1999","journal-title":"Prenatal Diagnosis"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0518|cit518","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1471-0528.1999.tb08186.x","article-title":"Serum markers for Down's syndrome in women who have had in vitro fertilisation: implications for antenatal screening","volume":"106","author":"Wald","year":"1999","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0519|cit519","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1056\/NEJM199908123410701","article-title":"Integrated screening for Down's syndrome on the basis of tests performed during the first and second trimesters.[see comment]","volume":"341","author":"Wald","year":"1999","journal-title":"New England Journal of Medicine"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0520|cit520","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/pd.627","article-title":"Combining nuchal translucency and serum markers in prenatal screening for Down syndrome in twin pregnancies","volume":"23","author":"Wald","year":"2003","journal-title":"Prenatal Diagnosis"},{"issue":"9360","key":"10.1002\/14651858.CD009925-BIB0521|cit521","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0140-6736(03)12680-3","article-title":"Antenatal screening for Down's syndrome with the quadruple test.[see comment]","volume":"361","author":"Wald","year":"2003","journal-title":"Lancet"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0522|cit522","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/pd.1498","article-title":"Sequential and contingent prenatal screening for Down syndrome","volume":"26","author":"Wald","year":"2006","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0523|cit523","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2265.1994.tb02579.x","article-title":"Evaluation of maternal serum immunoreactive Inhibin Aas a first trimester marker of Down's syndrome","volume":"41","author":"Wallace","year":"1994","journal-title":"Clinical Endocrinology"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0524|cit524","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/j.1471-0528.1997.tb14356.x","article-title":"Maternal serum inhibin-A in pregnancies complicated by insulin dependent diabetes mellitus","volume":"104","author":"Wallace","year":"1997","journal-title":"British Journal of Obstetrics & Gynaecology"},{"key":"10.1002\/14651858.CD009925-BIB0525|cit525","unstructured":"Ward A Nuchal translucency measurement Synergy (http:\/\/www.highbeam.com\/doc\/1P3-866108421.html) (accessed 2007) 2005"},{"issue":"8","key":"10.1002\/14651858.CD009925-BIB0526|cit526","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/(SICI)1097-0223(199608)16:8<691::AID-PD946>3.0.CO;2-2","article-title":"Effect of allowing for ethnic group in prenatal screening for Down's syndrome","volume":"16","author":"Watt","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"10","key":"10.1002\/14651858.CD009925-BIB0527|cit527","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/(SICI)1097-0223(199610)16:10<927::AID-PD972>3.0.CO;2-0","article-title":"Maternal serum inhibin-A levels in twin pregnancies: implications for screening for Down's syndrome","volume":"16","author":"Watt","year":"1996","journal-title":"Prenatal Diagnosis"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0528|cit528","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/pd.130","article-title":"First-trimester maternal serum human thyroid-stimulating hormone in chromosomally normal and Down syndrome pregnancies","volume":"21","author":"Weinans","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"5","key":"10.1002\/14651858.CD009925-BIB0529|cit529","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/pd.872","article-title":"A comparison of the impact of screen-positive results obtained from ultrasound and biochemical screening for Down syndrome in the first trimester: A pilot study","volume":"24","author":"Weinans","year":"2004","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0530|cit530","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1055\/s-2007-994526","article-title":"Trisomy 21 and cystic hygromas in early gestational age fetuses","volume":"11","author":"Welborn","year":"1994","journal-title":"American Journal of Perinatology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0531|cit531","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0002-9378(93)90007-6","article-title":"Evaluation of multiple-marker screening for Down syndrome in a statewide population","volume":"169","author":"Wenstrom","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0532|cit532","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/0002-9378(95)91374-2","article-title":"The influence of maternal weight on human chorionic gonadotropin in the multiple-marker screening test for fetal Down syndrome","volume":"173","author":"Wenstrom","year":"1995","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0533|cit533","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/0002-9378(95)91372-6","article-title":"Comparison of multiple-marker screening with amniocentesis for the detection of fetal aneuploidy in women greater than or equal35 years old","volume":"173","author":"Wenstrom","year":"1995","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0534|cit534","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1469-0705.1998.12060385.x","article-title":"The significance of choroid plexus cysts, echogenic heart foci and renal pyelectasis in the first trimester","volume":"12","author":"Whitlow","year":"1998","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0535|cit535","first-page":"245","article-title":"First trimester detection of fetal abnormalities in an unselected population","volume":"10","author":"Whitlow","year":"1998","journal-title":"Contemporary Reviews in Obstetrics and Gynaecology"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0536|cit536","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1471-0528.1999.tb08432.x","article-title":"The value of sonography in early pregnancy for the detection of fetal abnormalities in an unselected population","volume":"106","author":"Whitlow","year":"1999","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0537|cit537","first-page":"397","article-title":"Expanded maternal serum alpha fetoprotein screening","volume":"84","author":"Williamson","year":"1994","journal-title":"Iowa Medicine"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0538|cit538","first-page":"591","article-title":"New first-trimester prenatal screening for down syndrome","volume":"31","author":"Wilson","year":"2000","journal-title":"Laboratory Medicine"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0539|cit539","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/pd.124","article-title":"First trimester screening for Down syndrome and assisted reproduction: no basis for concern","volume":"21","author":"Wojdemann","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"2","key":"10.1002\/14651858.CD009925-BIB0540|cit540","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000072994","article-title":"Nasal bone hypoplasia: is it a common finding amongst chromosomally normal fetuses of southern Chinese women?","volume":"56","author":"Wong","year":"2003","journal-title":"Gynecologic & Obstetric Investigation"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0541|cit541","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/pd.1451","article-title":"Three-stage contingent screening for Down syndrome","volume":"26","author":"Wright","year":"2006","journal-title":"Prenatal Diagnosis"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0542|cit542","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0002-9378(98)70623-4","article-title":"The role of midtrimester targeted fetal organ screening combined with the \"triple test\" and maternal age in the diagnosis of trisomy 21: a retrospective study","volume":"178","author":"Yagel","year":"1998","journal-title":"American Journal of Obstetrics & Gynecology"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0543|cit543","first-page":"1154","article-title":"Total alpha-fetoprotein and Lens culinaris agglutinin-reactive alpha-fetoprotein in fetal chromosomal abnormalities","volume":"108","author":"Yamamoto","year":"2001","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology."},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0544|cit544","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1093\/humrep\/16.11.2438","article-title":"Lens culinaris agglutinin-reactive alpha-fetoprotein, an alternative variant to alpha-fetoprotein in prenatal screening for Down's syndrome","volume":"16","author":"Yamamoto","year":"2001","journal-title":"Human Reproduction"},{"issue":"1-2","key":"10.1002\/14651858.CD009925-BIB0545|cit545","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0009-8981(00)00381-8","article-title":"Alpha-fetoprotein microheterogeneity: a potential biochemical marker for Down's syndrome","volume":"304","author":"Yamamoto","year":"2001","journal-title":"Clinica Chimica Acta"},{"issue":"12","key":"10.1002\/14651858.CD009925-BIB0546|cit546","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/pd.178","article-title":"Effect of fetal gender on first trimester markers and on Down syndrome screening","volume":"21","author":"Yaron","year":"2001","journal-title":"Prenatal Diagnosis"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0547|cit547","first-page":"408","article-title":"The possibility of prenatal screening for fetal abnormalities in second-trimester pregnancies by measuring AFP, \u00df-HCG and uE-3 levels","volume":"16","author":"Ye","year":"1995","journal-title":"Xi'an Yike Daxue Xuebao"},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0548|cit548","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1447-0756.2000.tb01306.x","article-title":"Dimeric Inhibin A as a fourth marker for Down's syndrome maternal serum screening in native Japanese women","volume":"26","author":"Yoshida","year":"2000","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0549|cit549","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/pd.1970111106","article-title":"Estimating the risk of a fetal autosomal trisomy at mid-trimester using maternal serum alpha-fetoprotein and age: A retrospective study of 142 pregnancies","volume":"11","author":"Zeitune","year":"1991","journal-title":"Prenatal Diagnosis"},{"issue":"11","key":"10.1002\/14651858.CD009925-BIB0550|cit550","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.7863\/jum.2005.24.11.1487","article-title":"Variation of fetal nasal bone length in second-trimester fetuses according to race and ethnicity","volume":"24","author":"Zelop","year":"2005","journal-title":"Journal of Ultrasound in Medicine"},{"issue":"1","key":"10.1002\/14651858.CD009925-BIB0551|cit551","first-page":"94-6, 110","article-title":"Using maternal serum PAPP-A and other pregnancy-associated proteins in screening for fetal abnormalities","volume":"19","author":"Zhao","year":"1998","journal-title":"Xi'an Yike Daxue Xuebao"},{"issue":"6","key":"10.1002\/14651858.CD009925-BIB0552|cit552","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1046\/j.1471-0528.2003.02180.x","article-title":"Changes in nuchal translucency thickness in normal and abnormal karyotype fetuses","volume":"110","author":"Zoppi","year":"2003","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology."},{"issue":"3","key":"10.1002\/14651858.CD009925-BIB0553|cit553","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003252","article-title":"Amniocentesis and chorionic villus sampling for prenatal diagnosis","author":"Alfirevic","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"329(7470)","key":"10.1002\/14651858.CD009925-BIB0554|cit554","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1136\/bmj.329.7470.811","article-title":"Antenatal screening for Down's syndrome","volume":"9","author":"Alfirevic","year":"2004","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0555|cit555","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007384.pub2","article-title":"Antenatal screening for Down's syndrome: generic protocol (Protocol)","author":"Alldred","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0556|cit556","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s004040050089","article-title":"A sensitive enzyme immunoassay for pregnancy-associated plasma protein A (PAPP-A): a possible first trimester method of screening for Down syndrome and other trisomies","volume":"256","author":"Bersinger","year":"1995","journal-title":"Archives of Gynecology and Obstetrics"},{"issue":"9","key":"10.1002\/14651858.CD009925-BIB0557|cit557","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/pd.1970070904","article-title":"Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities","volume":"7","author":"Bogart","year":"1987","journal-title":"Prenatal Diagnosis"},{"key":"10.1002\/14651858.CD009925-BIB0558|cit558","doi-asserted-by":"crossref","unstructured":"Cuckle HS Holding S Jones R Wallace EM Groome NP Maternal serum dimeric inhibin A in second-trimester Down's syndrome pregnancies Prenatal Diagnosis 1995 385 6","DOI":"10.1002\/pd.1970150416"},{"issue":"4 Pt 1","key":"10.1002\/14651858.CD009925-BIB0559|cit559","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/0002-9378(90)90700-H","article-title":"Maternal serum Down syndrome screening: free beta-protein is a more effective marker than human chorionic gonadotropin","volume":"163","author":"Macri","year":"1990","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"7","key":"10.1002\/14651858.CD009925-BIB0560|cit560","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/pd.1970130704","article-title":"First-trimester free beta (hCG) screening for Down syndrome","volume":"13","author":"Macri","year":"1993","journal-title":"Prenatal Diagnosis"},{"issue":"5 Pt 2","key":"10.1002\/14651858.CD009925-BIB0561|cit561","first-page":"864","article-title":"Effect of study design on the association between nuchal translucency measurement and Down syndrome","volume":"94","author":"Mol","year":"1999","journal-title":"Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD009925-BIB0562|cit562","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF02984413","article-title":"The relative effects of parental and maternal age in mongolism","volume":"27","author":"Penrose","year":"1933","journal-title":"Journal of Genetics"},{"key":"10.1002\/14651858.CD009925-BIB0563|cit563","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(66)91387-0","article-title":"Chromosome analysis of human amniotic-fluid cells","volume":"i","author":"Steele","year":"1966","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD009925-BIB0564|cit564","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(68)92656-1","article-title":"Prenatal diagnosis of Down's syndrome","volume":"ii","author":"Vaklenti","year":"1968","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD009925-BIB0565|cit565","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/pd.1970150410","article-title":"Evaluation of maternal serum dimeric inhibin A as a first-trimester marker of Down's syndrome","volume":"15","author":"Wallace","year":"1995","journal-title":"Prenatal Diagnosis"},{"key":"10.1002\/14651858.CD009925-BIB0566|cit566","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2288-3-25","article-title":"The development of QUADAS:\u00a0 A tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews","volume":"3","author":"Whiting","year":"2003","journal-title":"BMC Medical Research Methodology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD009925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:10:40Z","timestamp":1744589440000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD009925"}},"subtitle":[],"editor":[{"name":"Cochrane Pregnancy and Childbirth Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,13]]},"references-count":566,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd009925","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,13]]}}}