{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:57:17Z","timestamp":1781499437434,"version":"3.54.1"},"update-to":[{"DOI":"10.1002\/14651858.cd009938","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000}}],"reference-count":65,"publisher":"Wiley","issue":"9","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd009938.pub2","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T09:45:22Z","timestamp":1441705522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack"],"prefix":"10.1002","volume":"2015","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"People's Hospital of Deyang City; Department of Neurology; No.173, Taishan North Road Deyang Sichuan China 618000"},{"name":"West China Hospital, Sichuan University; Department of Neurology; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University; Department of Neurology; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University; Department of Neurology; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University; Department of Neurology; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Hao","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University; Department of Neurology; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xuanwu Hospital, Capital Medical University; Department of Neurology; No. 45, Changchun Street Beijing Beijing China 100053"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan University of Science and Technology; Department of Neurology; No. 24, Jinghua Road Luoyang Henan Province China 471003"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"issue":"11","key":"10.1002\/14651858.CD009938.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa1009639","article-title":"Closure or medical therapy for cryptogenic stroke with patent foramen ovale","volume":"366","author":"Furlan","year":"2012","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD009938.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1056\/NEJMoa1211716","article-title":"Percutaneous closure of patent foramen ovale in cryptogenic embolism","volume":"368","author":"Meier","year":"2013","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD009938.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1056\/NEJMoa1301440","article-title":"Closure of patent foramen ovale versus medical therapy after cryptogenic stroke","volume":"368","author":"Carroll","year":"2013","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0004|cit4","unstructured":"Mooney MR CARDIA STAR trial: a United States randomized clinical trial of the CARDIA STAR patent foramen ovale closure system http:\/\/www.mplsheart.com\/pages\/Research.asp?ID=10&SID=28 (accessed by the Cochrane Stroke Group 2006)"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0005|cit5","unstructured":"Hansen CS Tonder N Iversen KK The effect of device closure of patent foramen ovale in elderly patients with cryptogenic stroke\/TCI ClinicalTrials.gov (http:\/\/www.ClinicalTrials.gov) 2009"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0006|cit6","unstructured":"Rosin L Berger F PEPSIS: Paraoxial Embolism Prevention Study in Ischemic Stroke PEPSIS Trial Website (http:\/\/www.pepsis.stroke-trial.com) (accessed by the Cochrane Stroke Group 2002)"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0007|cit7","unstructured":"Mas JL Patent foramen ovale closure or anticoagulants versus antiplatelet therapy to prevent stroke recurrence (CLOSE) ClinicalTrials.gov (http:\/\/www.ClinicalTrials.gov) 2007"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0008|cit8","unstructured":"Song JK Lee JY Device closure versus medical therapy for cryptogenic stroke patients with high-risk patent foramen ovale (DEFENSE-PFO) \u00a0 ClinicalTrials.gov (http:\/\/www.ClinicalTrials.gov) 2012"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0009|cit9","unstructured":"Kasner SE Rhodes JF Sondergaard L Thomassen L GORE HELEX septal occluder for patent foramen ovale (PFO) closure in stroke patients (Gore REDUCE) ClinicalTrials.gov (http:\/\/www.ClinicalTrials.gov) 2008"},{"issue":"1","key":"10.1002\/14651858.CD009938.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"35-41","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial: TOAST.Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"issue":"7","key":"10.1002\/14651858.CD009938.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jcin.2012.02.021","article-title":"Meta-analysis of transcatheter closure versus medical therapy for patent foramen ovale in prevention of recurrent neurological events after presumed paradoxical embolism","volume":"5","author":"Agarwal","year":"2012","journal-title":"JACC Cardiovascular Interventions"},{"issue":"4","key":"10.1002\/14651858.CD009938.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/ccd.20108","article-title":"Transcatheter patent foramen ovale closure for secondary prevention of paradoxical embolic events: acute results from the FORECAST registry","volume":"62","author":"Alameddine","year":"2004","journal-title":"Catheterization and Cardiovascular Interventions"},{"issue":"2","key":"10.1002\/14651858.CD009938.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1212\/WNL.0b013e3181aa2a19","article-title":"Recurrent cerebral ischemia in medically treated patent foramen ovale: a meta-analysis","volume":"73","author":"Almekhlafi","year":"2009","journal-title":"Neurology"},{"issue":"7","key":"10.1002\/14651858.CD009938.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1161\/STROKEAHA.109.547828","article-title":"Patent foramen ovale in cryptogenic stroke: incidental or pathogenic?","volume":"40","author":"Alsheikh-Ali","year":"2009","journal-title":"Stroke"},{"issue":"5","key":"10.1002\/14651858.CD009938.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ehj.2003.10.021","article-title":"Transcatheter closure of patent foramen ovale (PFO) in patients with paradoxical embolism: periprocedural safety and mid-term follow-up results of three different device occluder systems","volume":"25","author":"Braun","year":"2004","journal-title":"European Heart Journal"},{"issue":"11","key":"10.1002\/14651858.CD009938.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.4244\/EIJV9I11A225","article-title":"Updating the evidence on patent foramen ovale closure versus medical therapy in patients with cryptogenic stroke: a systematic review and comprehensive meta-analysis of 2,303 patients from three randomised trials and 2,231 patients from 11 observational studies","volume":"9","author":"Capodanno","year":"2014","journal-title":"EuroIntervention"},{"issue":"4","key":"10.1002\/14651858.CD009938.pub2-BIB0017|cit17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11883-010-0114-7","article-title":"Patent foramen ovale and stroke: should PFOs be closed in otherwise cryptogenic stroke?","volume":"12","author":"Carpenter","year":"2010","journal-title":"Current Atherosclerosis Reports"},{"issue":"1","key":"10.1002\/14651858.CD009938.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000341924","article-title":"Patent foramen ovale, ischemic stroke and migraine: systematic review and stratified meta-analysis of association studies","volume":"40","author":"Davis","year":"2013","journal-title":"Neuroepidemiology"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0019|cit19","unstructured":"De Cillis E Basile DP Acquaviva T De Blasi R Petruzzellis M Bortone AS Abstract 8807: Efficacy and effectiveness evaluation of secondary prevention of cryptogenic stroke or TIA in patients with PFO successfully treated by percutaneous approach: six years follow-up Circulation 2010 A8807"},{"issue":"7","key":"10.1002\/14651858.CD009938.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"797-802","DOI":"10.1016\/j.jacc.2006.08.063","article-title":"Patent foramen ovale and the risk of ischemic stroke in a multiethnic population","volume":"49","author":"Tullio","year":"2007","journal-title":"Journal of the American College of Cardiology"},{"issue":"5","key":"10.1002\/14651858.CD009938.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/MOH.0b013e32832d47dd","article-title":"Patent foramen ovale and stroke: what should be done?","volume":"16","author":"Tullio","year":"2009","journal-title":"Current Opinion in Hematology"},{"issue":"2","key":"10.1002\/14651858.CD009938.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.echo.2009.12.008","article-title":"Patent foramen ovale: echocardiographic detection and clinical relevance in stroke","volume":"23","author":"Tullio","year":"2010","journal-title":"Journal of the American Society of Echocardiography"},{"issue":"9624","key":"10.1002\/14651858.CD009938.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0140-6736(08)60694-7","article-title":"Stroke","volume":"371","author":"Donnan","year":"2008","journal-title":"Lancet"},{"issue":"7109","key":"10.1002\/14651858.CD009938.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0025|cit25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1161\/STR.0b013e3181f7d043","article-title":"Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack. A guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"Furie","year":"2011","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1161\/STROKEAHA.110.593376","article-title":"Study design of the CLOSURE I trial: a prospective, multicenter, randomized, controlled trial to evaluate the safety and efficacy of the STARFlex Septal Closure System versus best medical therapy in patients with stroke or transient ischemic attack due to presumed paradoxical embolism through a patent foramen ovale","volume":"41","author":"Furlan","year":"2010","journal-title":"Stroke"},{"issue":"11","key":"10.1002\/14651858.CD009938.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1161\/hs1101.098524","article-title":"Risk factors, outcome, and treatment subtypes of ischemic stroke: the German stroke data bank","volume":"32","author":"Grau","year":"2001","journal-title":"Stroke"},{"issue":"6","key":"10.1002\/14651858.CD009938.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.carrev.2013.08.010","article-title":"Safety and efficacy of device closure for patent foramen ovale for secondary prevention of neurological events: comprehensive systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Hakeem","year":"2013","journal-title":"Cardiovascular Revascularization Medicine"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0029|cit29","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration 2011 Available from www.cochrane-handbook.org"},{"issue":"4","key":"10.1002\/14651858.CD009938.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/ccd.10674","article-title":"Transcatheter closure of patent foramen ovale associated with paradoxical embolism using the amplatzer PFO occluder: initial and intermediate-term results of the US multicenter clinical trial","volume":"60","author":"Hong","year":"2003","journal-title":"Catheterization and Cardiovascular Interventions"},{"issue":"43","key":"10.1002\/14651858.CD009938.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1093\/eurheartj\/eht283","article-title":"Long-term results of a randomized trial comparing three different devices for percutaneous closure of a patent foramen ovale","volume":"34","author":"Hornung","year":"2013","journal-title":"European Heart Journal"},{"issue":"9","key":"10.1002\/14651858.CD009938.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.7326\/0003-4819-139-9-200311040-00010","article-title":"Transcatheter closure versus medical therapy of patent foramen ovale and presumed paradoxical thromboemboli","volume":"139","author":"Khairy","year":"2003","journal-title":"Annals of Internal Medicine"},{"issue":"12","key":"10.1002\/14651858.CD009938.pub2-BIB0033|cit33","first-page":"1316-23","article-title":"Device closure of patent foramen ovale versus medical therapy in cryptogenic Stroke","volume":"6","author":"Khan","year":"2013","journal-title":"Journal of the American College of Cardiology"},{"issue":"9","key":"10.1002\/14651858.CD009938.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1161\/STROKEAHA.113.001773","article-title":"Potentially large yet uncertain benefits: a meta-analysis of patent foramen ovale closure trials","volume":"44","author":"Kitsios","year":"2013","journal-title":"Stroke"},{"issue":"1","key":"10.1002\/14651858.CD009938.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2217\/ica.09.36","article-title":"Different patent foramen ovale closure techniques in varying anatomies","volume":"2","author":"Ko","year":"2010","journal-title":"Interventional Cardiology"},{"issue":"4","key":"10.1002\/14651858.CD009938.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1016\/j.ijcard.2013.07.077","article-title":"Percutaneous closure of patent foramen ovale for cryptogenic stroke: a meta-analysis of randomized controlled trials","volume":"168","author":"Kwong","year":"2013","journal-title":"International Journal of Cardiology"},{"issue":"2","key":"10.1002\/14651858.CD009938.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000088097","article-title":"The Hallym Stroke Registry: a web-based stroke data bank with an analysis of 1,654 consecutive patients with acute stroke","volume":"54","author":"Lee","year":"2005","journal-title":"European Neurology"},{"issue":"5","key":"10.1002\/14651858.CD009938.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S1474-4422(07)70004-2","article-title":"Stroke in China: epidemiology, prevention, and management strategies","volume":"6","author":"Liu","year":"2007","journal-title":"Lancet Neurology"},{"issue":"3","key":"10.1002\/14651858.CD009938.pub2-BIB0039|cit39","first-page":"e21","article-title":"Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"119","author":"Lloyd-Jones","year":"2009","journal-title":"Circulation"},{"issue":"19","key":"10.1002\/14651858.CD009938.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1161\/CIRCULATIONAHA.110.961920","article-title":"Paradoxical embolism","volume":"122","author":"Maron","year":"2010","journal-title":"Circulation"},{"issue":"2","key":"10.1002\/14651858.CD009938.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1747-4949.2010.00413.x","article-title":"Prevention of stroke in patients with patent foramen ovale","volume":"5","author":"Mattle","year":"2010","journal-title":"International Journal of Stroke"},{"issue":"2","key":"10.1002\/14651858.CD009938.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jacc.2005.10.044","article-title":"Patent foramen ovale: innocent or guilty? Evidence from a prospective population-based study","volume":"47","author":"Meissner","year":"2006","journal-title":"Journal of the American College of Cardiology"},{"issue":"11","key":"10.1002\/14651858.CD009938.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.hlc.2013.07.022","article-title":"Is transcatheter closure better than medical therapy for cryptogenic stroke with patent foramen ovale? A meta-analysis of randomised trials","volume":"22","author":"Nagaraja","year":"2013","journal-title":"Heart, Lung and Circulation"},{"issue":"2","key":"10.1002\/14651858.CD009938.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijcard.2013.08.058","article-title":"PFO closure vs. medical therapy in cryptogenic stroke or transient ischemic attack: a systematic review and meta-analysis","volume":"169","author":"Ntaios","year":"2013","journal-title":"International Journal of Cardiology"},{"issue":"21","key":"10.1002\/14651858.CD009938.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/j.jacc.2009.04.001","article-title":"Percutaneous device closure of patent foramen ovale for secondary stroke prevention: a call for completion of randomized clinical trial","volume":"53","author":"O'Gara","year":"2009","journal-title":"Journal of the American College of Cardiology"},{"issue":"7","key":"10.1002\/14651858.CD009938.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00007611-200194070-00016","article-title":"Secondary prevention of cerebral ischemia in patent foramen ovale: systematic review and meta-analysis","volume":"94","author":"Orgera","year":"2001","journal-title":"Southern Medical Journal"},{"issue":"8","key":"10.1002\/14651858.CD009938.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"1172-9","DOI":"10.1212\/WNL.55.8.1172","article-title":"Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies","volume":"55","author":"Overell","year":"2000","journal-title":"Neurology"},{"issue":"2","key":"10.1002\/14651858.CD009938.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000321334","article-title":"Risk of recurrent cerebrovascular events in patients with cryptogenic stroke or transient ischemic attack and patent foramen ovale: the FORI (Foramen Ovale Registro Italiano) study","volume":"31","author":"Paciaroni","year":"2010","journal-title":"Cerebrovascular Diseases"},{"issue":"4","key":"10.1002\/14651858.CD009938.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.hlc.2013.12.003","article-title":"PFO occluder device may prevent recurrent stroke in patients with patent foramen ovale and cryptogenic stroke: a meta-analysis of randomised trials","volume":"23","author":"Pandit","year":"2014","journal-title":"Heart, Lung and Circulation"},{"issue":"12","key":"10.1002\/14651858.CD009938.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1161\/01.STR.30.12.2513","article-title":"Ischemic stroke subtypes. A population-based study of incidence and risk factor","volume":"30","author":"Petty","year":"1999","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0051|cit51","doi-asserted-by":"crossref","unstructured":"Pickett C Villines T Ferguson M Hulten E Cost analysis of percutaneous closure versus medical therapy for cryptogenic stroke patients with a patent foramen ovale 37th Annual Scientific Sessions of the Society for Cardiovascular Angiography and Interventions', SCAI 2014 Las Vegas, NV United States 2014","DOI":"10.14503\/THIJ-13-3879"},{"issue":"6","key":"10.1002\/14651858.CD009938.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/ccd.25122","article-title":"A meta-analysis of transcatheter closure of patent foramen ovale versus medical therapy for prevention of recurrent thromboembolic events in patients with cryptogenic cerebrovascular events","volume":"82","author":"Pineda","year":"2013","journal-title":"Catheterization and Cardiovascular"},{"issue":"43","key":"10.1002\/14651858.CD009938.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"3342-52","DOI":"10.1093\/eurheartj\/eht285","article-title":"Patent foramen ovale transcatheter closure vs. medical therapy on recurrent vascular events: a systematic review and meta-analysis of randomized controlled trials","volume":"34","author":"Rengifo-Moreno","year":"2013","journal-title":"European Heart Journal"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0054|cit54","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2261-13-116","article-title":"Transcatheter patent foramen ovale closure versus medical therapy for cryptogenic stroke: a meta-analysis of randomized clinical trials","volume":"13","author":"Riaz","year":"2013","journal-title":"BMC Cardiovascular Disorders"},{"issue":"4","key":"10.1002\/14651858.CD009938.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/ana.410250410","article-title":"Infarcts of undetermined cause: the NINCDS Stroke Data Bank","volume":"25","author":"Sacco","year":"1989","journal-title":"Annals of Neurology"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0057|cit57","doi-asserted-by":"publisher","first-page":"e004282","DOI":"10.1136\/bmjopen-2013-004282","article-title":"Systematic review of percutaneous closure versus medical therapy in patients with cryptogenic stroke and patent foramen ovale","volume":"4","author":"Spencer","year":"2014","journal-title":"BMJ Open"},{"issue":"9","key":"10.1002\/14651858.CD009938.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"1353-8","DOI":"10.1016\/j.amjcard.2007.12.040","article-title":"Comparison of three patent foramen ovale closure devices in a randomized trial (Amplatzer\u00ae versus CardioSEAL\u00ae-STARflex\u00ae versus HELEX\u00ae occluder)","volume":"101","author":"Taaffe","year":"2008","journal-title":"American Journal of Cardiology"},{"issue":"2","key":"10.1002\/14651858.CD009938.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1212\/WNL.0b013e3181aa2a4d","article-title":"Patent foramen ovale and ischemic stroke recurrence: the end of a never-ending story?","volume":"73","author":"Tamayo","year":"2009","journal-title":"Neurology"},{"issue":"1","key":"10.1002\/14651858.CD009938.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/WCO.0b013e3283352dbc","article-title":"Rethinking trial strategies for stroke and patent foramen ovale","volume":"23","author":"Thaler","year":"2010","journal-title":"Current Opinion in Neurology"},{"key":"10.1002\/14651858.CD009938.pub2-BIB0061|cit61","doi-asserted-by":"crossref","unstructured":"Udell JA Opotowsky AR Khairy P Silversides CK Gladstone DJ O'Gara PT Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology 2014 1216 24","DOI":"10.1016\/j.cjca.2014.05.004"},{"issue":"4","key":"10.1002\/14651858.CD009938.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000229553","article-title":"Current management and risk of recurrent stroke in cerebrovascular patients with right-to-left cardiac shunt","volume":"28","author":"Weimar","year":"2009","journal-title":"Cerebrovascular Diseases"},{"issue":"4","key":"10.1002\/14651858.CD009938.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jacc.2004.05.044","article-title":"Comparison of medical treatment with percutaneous closure of patent foramen ovale in patients with cryptogenic stroke","volume":"44","author":"Windecker","year":"2004","journal-title":"Journal of the American College of Cardiology"},{"issue":"5","key":"10.1002\/14651858.CD009938.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/heartjnl-2013-304394","article-title":"Stroke prevention by percutaneous closure of patent foramen ovale: a systematic review and meta-analysis","volume":"100","author":"Wolfrum","year":"2014","journal-title":"Heart"},{"issue":"9533","key":"10.1002\/14651858.CD009938.pub2-BIB0065|cit65","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/S0140-6736(06)69087-9","article-title":"Closure of patent foramen ovale after cryptogenic stroke","volume":"368","author":"W\u00f6hrle","year":"2006","journal-title":"Lancet"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD009938.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T16:47:34Z","timestamp":1656002854000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD009938.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Stroke Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,8]]},"references-count":65,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd009938.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,8]]}}}