{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:31:50Z","timestamp":1789803110353,"version":"4.0.1"},"update-to":[{"DOI":"10.1002\/14651858.cd010061","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T00:00:00Z","timestamp":1426032000000}}],"reference-count":53,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd010061.pub2","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T05:03:43Z","timestamp":1426050223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low-birth-weight infants"],"prefix":"10.1002","author":[{"given":"Arne","family":"Ohlsson","sequence":"first","affiliation":[{"name":"University of Toronto; Departments of Paediatrics, Obstetrics and Gynaecology and Institute of Health Policy, Management and Evaluation; 600 University Avenue Toronto ON Canada M5G 1X5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakeshkumar S","family":"Shah","sequence":"additional","affiliation":[{"name":"University of Toronto Mount Sinai Hospital; Department of Paediatrics and Health Policy, Management and Evaluation; 600 University Avenue Toronto ON Canada M5G 1XB"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,11]]},"reference":[{"issue":"11","key":"10.1002\/14651858.CD010061.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"e77888","DOI":"10.1371\/journal.pone.0077888","article-title":"Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: A randomized controlled trial","volume":"8","author":"Dang","year":"2013","journal-title":"PLos ONE"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0002|cit2","first-page":"S0022-3476(13)0","article-title":"Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: A randomized controlled trial","volume":"13","author":"Oncel","year":"2013","journal-title":"The Journal of Pediatrics"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0003|cit3","first-page":"S54","article-title":"Prophylactic treatment with oral paracetamol for patent ductus arteriosus in preterm infants admitted in NICU Vali-Asr Hospital in 2012","volume":"23","author":"Zarkesh","year":"2013","journal-title":"Iranian Journal of Pediatrics"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0004|cit4","unstructured":"NCT01291654 Paracetamol in the treatment of patent ductus arteriosus in the premature neonate Clinicaltrials.gov\/show\/NCT01291654 (December 2013)"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0005|cit5","unstructured":"NCT01938261 The preterm infants' paracetamol study (PreParaS) Clinicaltrials.gov\/show\/NCT01938261 (December 2013)"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0006|cit6","unstructured":"NCT02002741 Adding paracetamol to ibuprofen for treatment of patent ductus arteriosus in preterm infants ClinicalTrials.gov\/show\/NCT02002741 (December 2013)"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0007|cit7","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1034\/j.1399-6576.2001.450104.x","article-title":"Treatment with paracetamol in infants","volume":"45","author":"Arana","year":"2001","journal-title":"Acta Anaesthesiologica Scandinavica"},{"issue":"11","key":"10.1002\/14651858.CD010061.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1460-9592.2007.02322.x","article-title":"Intravenous paracetamol: the 'Stockholm protocol' for postoperative analgesia of term and preterm neonates","volume":"17","author":"Bartocci","year":"2007","journal-title":"Pediatric Anesthesia"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-069X-12-41","article-title":"Prenatal and perinatal analgesic exposure and autism: an ecological link","volume":"12","author":"Bauer","year":"2013","journal-title":"Environmental Health"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"S202","DOI":"10.1086\/317520","article-title":"Mechanism of action of acetaminophen: is there a cyclooxgygenase 3?","volume":"31 Suppl 5","author":"Botting","year":"2000","journal-title":"Clinical Infectious Diseases"},{"issue":"10","key":"10.1002\/14651858.CD010061.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1056\/NEJM200009073431009","article-title":"Ibuprofen and patent ductus arteriosus","volume":"343","author":"Clyman","year":"2000","journal-title":"The New England Journal of Medicine"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0013|cit13","unstructured":"U.S. National Library of Medicine Acetaminophen\/Paracetamol Drug Information Portal (druginfo.nlm.nih.gov\/drugportal) 2012"},{"issue":"8704","key":"10.1002\/14651858.CD010061.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0140-6736(90)93030-S","article-title":"Effects of indomethacin on cerebral haemodynamics in very preterm infants","volume":"335","author":"Edwards","year":"1990","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD010061.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1542\/peds.2005-0249","article-title":"Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia","volume":"116","author":"Ehrenkranz","year":"2005","journal-title":"Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD010061.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/pr.2014.82","article-title":"Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies","volume":"76","author":"El-Khuffash","year":"2014","journal-title":"Pediatric Research"},{"issue":"7","key":"10.1002\/14651858.CD010061.pub2-BIB0017|cit17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000174.pub2","article-title":"Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants","author":"Fowlie","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0018|cit18","doi-asserted-by":"crossref","unstructured":"McMaster University, 2014 GRADEpro 2014","DOI":"10.1186\/1687-9856-2014-S1-S1"},{"issue":"3","key":"10.1002\/14651858.CD010061.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0090-6980(89)90001-4","article-title":"Pronounced reduction of in vivo prostacyclin synthesis in humans by acetaminophen (paracetamol)","volume":"37","author":"Gr\u00e8en","year":"1989","journal-title":"Prostaglandins"},{"issue":"4","key":"10.1002\/14651858.CD010061.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"2","key":"10.1002\/14651858.CD010061.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0095-5108(18)30293-8","article-title":"Patent ductus arteriosus. Clinical relevance of prostaglandins and prostaglandin inhibitors in PDA pathophysiology and treatment","volume":"22","author":"Hammerman","year":"1995","journal-title":"Clinics in Perinatology"},{"issue":"6","key":"10.1002\/14651858.CD010061.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"e1618","DOI":"10.1542\/peds.2011-0359","article-title":"Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment","volume":"128","author":"Hammerman","year":"2011","journal-title":"Pediatrics"},{"issue":"7414","key":"10.1002\/14651858.CD010061.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0024|cit24","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011], The Cochrane Collaboration Available from www.cochrane-handbook.org"},{"issue":"5","key":"10.1002\/14651858.CD010061.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"20","author":"Hozo","year":"2005","journal-title":"BMC Medical Reseach Methodology"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia. NICHD\/NHLB\/ORD Workshop summary","volume":"163","author":"Jobe","year":"2001","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"16","key":"10.1002\/14651858.CD010061.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3109\/14767058.2013.871630","article-title":"Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series","volume":"27","author":"Kessel","year":"2014","journal-title":"Journal of Maternal-Fetal & Neonatal Medicine"},{"issue":"2","key":"10.1002\/14651858.CD010061.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/1060028014557564","article-title":"Acetaminophen for patent ductus arteriosus","volume":"49","author":"Le","year":"2015","journal-title":"Annals of Pharmacotherapy"},{"issue":"5","key":"10.1002\/14651858.CD010061.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1542\/peds.106.5.1070","article-title":"Variations in practice and outcomes in the Canadian NICU network 1996-1997","volume":"106","author":"Lee","year":"2000","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"F459","DOI":"10.1136\/fn.88.6.F459","article-title":"Treatment of jaundice in low birthweight infants","volume":"88","author":"Maisels","year":"2003","journal-title":"Archives of Disease in Childhood. Fetal and Neonatal Edition"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0031|cit31","first-page":"924","article-title":"Development of the pulmonary circulation: metabolic aspects","volume-title":"Fetal and Neonatal Physiology","volume":"1","author":"Mathew","year":"1998"},{"issue":"10","key":"10.1002\/14651858.CD010061.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/jp.2014.96","article-title":"Paracetamol treatment of patent ductus arteriosus in preterm infants","volume":"34","author":"Nadir","year":"2014","journal-title":"Journal of Perinatology"},{"issue":"4","key":"10.1002\/14651858.CD010061.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0022-3476(78)80917-2","article-title":"Improved lung compliance after ligation of patent ductus arteriosus in hyaline membrane disease","volume":"93","author":"Naulty","year":"1978","journal-title":"Journal of Pediatrics"},{"issue":"1-2","key":"10.1002\/14651858.CD010061.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000457546","article-title":"Effect of indomethacin on cerebral blood flow velocities in very low birth weight neonates with patent ductus arteriosus","volume":"20","author":"Ohlsson","year":"1993","journal-title":"Developmental Pharmacology and Therapeutics"},{"issue":"7","key":"10.1002\/14651858.CD010061.pub2-BIB0035|cit35","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004213.pub3","article-title":"Ibuprofen for the prevention of patent ductus arteriosus in preterm and\/or low birth weight infants","author":"Ohlsson","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD010061.pub2-BIB0036|cit36","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003481.pub6","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants","author":"Ohlsson","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD010061.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bja\/aen208","article-title":"I.V. acetaminophen pharmacokinetics in neonates after multiple doses","volume":"101","author":"Palmer","year":"2008","journal-title":"British Journal of Anaesthesia"},{"issue":"7","key":"10.1002\/14651858.CD010061.pub2-BIB0038|cit38","first-page":"2309","article-title":"Consequences associated with nonnarcotic analgesics in the fetus and newborn","volume":"44","author":"Peterson","year":"1985","journal-title":"Federation Proceedings"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0039|cit39","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) Version 5.3 2014"},{"issue":"3","key":"10.1002\/14651858.CD010061.pub2-BIB0040|cit40","first-page":"313","article-title":"Therapy of symptomatic patent ductus arteriosus in preterms with mefenemic acid and indomethacin","volume":"29","author":"Sakhalkar","year":"1992","journal-title":"Indian Pediatrics"},{"issue":"6","key":"10.1002\/14651858.CD010061.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.zefq.2009.05.023","article-title":"GRADE: From grading the evidence to developing recommendations. A description of the system and a proposal regarding the transferabiity of the results to clinical practice","volume":"103","author":"Sch\u00fcnemann","year":"2009","journal-title":"Zeitschrift f\u00fcr Evidenz, Fortbildung und Qualit\u00e4t im Gesundheitswesen"},{"issue":"6","key":"10.1002\/14651858.CD010061.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0022-3476(83)80736-7","article-title":"Effect of prolonged indomethacin therapy on renal function and selected vasoactive hormones in very-low-birth-weight infants with symptomatic patent ductus arteriosus","volume":"103","author":"Seyberth","year":"1993","journal-title":"Journal of Pediatrics"},{"issue":"4","key":"10.1002\/14651858.CD010061.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/01443610220141489","article-title":"In utero ductal closure following near-term maternal self-medication with nimesulide and acetaminophen","volume":"22","author":"Simbi","year":"2002","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"1","key":"10.1002\/14651858.CD010061.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/2249-4847.109245","article-title":"An interesting observation of PDA closure with oral paracetamol in preterm neonates","volume":"2","author":"Sinah","year":"2013","journal-title":"Journal of Clinical Neonatology"},{"issue":"5","key":"10.1002\/14651858.CD010061.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jpeds.2011.04.016","article-title":"Characterization and outcomes of young infants with acute liver failure","volume":"159","author":"Sundaram","year":"2011","journal-title":"The Journal of Pediatrics"},{"key":"10.1002\/14651858.CD010061.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1824-7288-40-21","article-title":"Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates","volume":"40","author":"Terrin","year":"2014","journal-title":"Italian Journal of Pediatrics"},{"issue":"16","key":"10.1002\/14651858.CD010061.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1161\/CIRCULATIONAHA.110.969584","article-title":"Pediatric pulmonary hypertension in the Netherlands, Epidemiology and characterization during the period 1991 to 2005","volume":"124","author":"Loon","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"10.1002\/14651858.CD010061.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/toxsci\/kft329","article-title":"Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response in adult male mice","volume":"138","author":"Viberg","year":"2014","journal-title":"Toxicological Sciences"},{"issue":"2","key":"10.1002\/14651858.CD010061.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/sj.jp.7211641","article-title":"Acetaminophen-induced hepatic failure with encephalopathy in a newborn","volume":"27","author":"Walls","year":"2007","journal-title":"Journal of Perinatology"},{"issue":"6","key":"10.1002\/14651858.CD010061.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s004310051125","article-title":"A patent ductus arteriosus is associated with reduced middle cerebral artery blood flow velocity","volume":"158","author":"Weir","year":"1999","journal-title":"European Journal of Pediatrics"},{"issue":"4","key":"10.1002\/14651858.CD010061.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1460-9592.2009.02947.x","article-title":"Survey of i.v. paracetamol (acetaminophen) use in neonates and infants under 1 year of age by UK anesthetists","volume":"19","author":"Wilson-Smith","year":"2009","journal-title":"Pediatric Anesthesia"},{"issue":"4","key":"10.1002\/14651858.CD010061.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0022-3468(89)80284-2","article-title":"Localized intestinal perforation following intravenous indomethacin in premature infants","volume":"24","author":"Wolf","year":"1989","journal-title":"Journal of Pediatric Surgery"},{"issue":"8","key":"10.1002\/14651858.CD010061.pub2-BIB0053|cit53","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3109\/14767058.2012.755162","article-title":"A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol","volume":"26","author":"Yurttutan","year":"2013","journal-title":"Journal of Maternal-Fetal & Neonatal Medicine"}],"updated-by":[{"DOI":"10.1002\/14651858.cd010061.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD010061.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T22:39:52Z","timestamp":1628548792000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD010061.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Neonatal Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,11]]},"references-count":53,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd010061.pub2","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD010061.pub3","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,11]]}}}