{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:59:28Z","timestamp":1774526368567,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd010290","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000}}],"reference-count":50,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd010290.pub2","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T03:09:30Z","timestamp":1441768170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Gonadotrophins for ovulation induction in women with polycystic ovarian syndrome"],"prefix":"10.1002","author":[{"given":"Nienke S","family":"Weiss","sequence":"first","affiliation":[{"name":"Free Medical University; Center for Reproductive Medicine; De Boelelaan 1105 Amsterdam Netherlands 1081 HV"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen","family":"Nahuis","sequence":"additional","affiliation":[{"name":"Medisch Spectrum Twente; Enschede Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neriman","family":"Bayram","sequence":"additional","affiliation":[{"name":"Zaans Medisch Centrum; Department of Obstetrics and Gynaecology; koningin Julianaplein 58 Zaandam Netherlands 1502 DV"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben Willem J","family":"Mol","sequence":"additional","affiliation":[{"name":"The University of Adelaide; The Robinson Institute, School of Paediatrics and Reproductive Health; Level 3, Medical School South Building Frome Road Adelaide South Australia Australia SA 5005"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulco","family":"Van der Veen","sequence":"additional","affiliation":[{"name":"Academic Medical Center, University of Amsterdam; Center for Reproductive Medicine; Meibergdreef 9 Amsterdam Netherlands 1105 AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madelon","family":"van Wely","sequence":"additional","affiliation":[{"name":"Academic Medical Center, University of Amsterdam; Center for Reproductive Medicine; Meibergdreef 9 Amsterdam Netherlands 1105 AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"issue":"7","key":"10.1002\/14651858.CD010290.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/humrep\/dem075","article-title":"Highly purified FSH is as efficacious as recombinant FSH for ovulation induction in women with WHO Group II anovulatory infertility: a randomized controlled non-inferiority trial","volume":"22","author":"Balen","year":"2007","journal-title":"Human Reproduction"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0015-0282(97)00423-8","article-title":"Recombinant follicle-stimulating hormone (FSH; Puregon) is more efficient than urinary FSH (Metrodin) in women with clomiphene-resistant, normogonadotropic, chronic anovulation; a prospective, multicenter, assessor-blind, randomized, clinical trial","volume":"69","author":"Coelingh Bennink","year":"1998","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1002\/14651858.CD010290.pub2-BIB0003|cit3","first-page":"297","article-title":"A new highly purified human-derived FSH, Bravelle, is as effective and well tolerated as recombinant follitropin beta in ovulation induction in infertile women with ovulatory dysfunction","volume":"19","author":"Feigenbaum","year":"2001","journal-title":"Today's Therapeutic Trends"},{"issue":"5","key":"10.1002\/14651858.CD010290.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-2265.1990.tb03896.x","article-title":"Ovarian electrocautery versus human menopausal gonadotrophins and pure follicle stimulating hormone therapy in the treatment of patients with polycystic ovarian disease.","volume":"33","author":"Gadir","year":"1990","journal-title":"Clinical Endocrinology"},{"issue":"5","key":"10.1002\/14651858.CD010290.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S1472-6483(10)61632-X","article-title":"Ovulation induction with urinary FSH or recombinant FSH in polycystic ovary syndrome patients: a prospective randomized analysis of cost-effectiveness","volume":"9","author":"Gerli","year":"2004","journal-title":"Reproductive BioMedicine Online"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/humrep\/11.suppl_5.95","article-title":"Clinical assessment of human gonadotrophins produced by recombinant DNA technology","volume":"11","author":"Loumaye","year":"1996","journal-title":"Human Reproduction"},{"issue":"5","key":"10.1002\/14651858.CD010290.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0015-0282(16)53511-0","article-title":"Treatment of clomiphene citrate-resistant polycystic ovarian syndrome with pure follicle-stimulating hormone or human menopausal gonadotropin","volume":"53","author":"McFaul","year":"1990","journal-title":"Fertility and Sterility"},{"issue":"7","key":"10.1002\/14651858.CD010290.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1093\/humrep\/del085","article-title":"Similar ovulation rates, but different follicular development with highly purified menotrophin compared with recombinant FSH in WHO Group II anovulatory infertility: a randomized controlled study","volume":"21","author":"Platteau","year":"2006","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1477-7827-4-38","article-title":"Recombinant versus highly-purified, urinary follicle-stimulating hormone (r-FSH vs. HP-uFSH) in ovulation induction: a prospective, randomized study with cost-minimization analysis","volume":"4","author":"Revelli","year":"2006","journal-title":"Reproductive Biology and Endocrinology"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0015-0282(16)54059-X","article-title":"A comparative, randomized study of low-dose human menopausal gonadotropin and follicle-stimulating hormone in women with polycystic ovarian syndrome","volume":"55","author":"Sagle","year":"1991","journal-title":"Fertility and Sterility"},{"issue":"5","key":"10.1002\/14651858.CD010290.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0015-0282(16)48551-1","article-title":"Ovulatoin induction in polycystic ovary syndrome with urinary follicle-stimulating hormone or human menopausal gonadotropin","volume":"43","author":"Seibel","year":"1985","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/09513590310001651731","article-title":"Low-dose ovulation induction with urinary gonadotrophins or recombinant follicle stimulating hormone in patients with polycystic ovary syndrome","volume":"18","author":"Szil\u00e1gyi","year":"2004","journal-title":"Gynaecological Endocrinology"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12522-010-0046-5","article-title":"Recombinant follicle stimulating hormone (follitropin alfa) versus purified urinary follicle stimulating hormone in a low dose step up regimen to induce ovualtion in japanese women with anti-estrogen-ineffective oligo- or anovulatory infertility","volume":"9","author":"Taketani","year":"2010","journal-title":"Reproductive Medicine and Biology"},{"issue":"2","key":"10.1002\/14651858.CD010290.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0015-0282(99)00209-5","article-title":"Urinary follicle-stimulating hormone (FSH) versus recombinant FSH in clomiphene citrate-resistant, normogonadotropic, chronic anovulation: a prospective randomized study","volume":"72","author":"Yarali","year":"1999","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/oxfordjournals.humrep.a137035","article-title":"Combined luteinizing hormone releasing hormone analogue and exogenous gonadotrophins for the treatment of infertility associated with polycystic ovaries","volume":"5","author":"Homburg","year":"1990","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-94-009-3229-6_20","article-title":"Profertility uses of LHRH agonist analogues","volume-title":"LHRH and its Analogues; Contraceptive and Therapeutic Application. Part 2","author":"Jacobs","year":"1987"},{"issue":"3","key":"10.1002\/14651858.CD010290.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0015-0282(16)53335-4","article-title":"Comparison of urinary human follicle-stimulating hormone and human menopausal gonadotropin for ovarian stimulation in polycystic ovarian syndrome","volume":"53","author":"Larsen","year":"1990","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1002\/14651858.CD010290.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/humrep\/deh185","article-title":"Impact of highly purified urinary FSH and recombinant FSH on haemostasis: an open-label, randomized, controlled trial","volume":"19","author":"Ricci","year":"2004","journal-title":"Human Reproduction"},{"issue":"6543","key":"10.1002\/14651858.CD010290.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/bmj.293.6543.355","article-title":"Prevelance of polycystic ovaries in women with anovulation and idiopathic hirsutism","volume":"293","author":"Adams","year":"1986","journal-title":"British Medical Journal (Clinical Research ed.)"},{"issue":"8","key":"10.1002\/14651858.CD010290.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/oxfordjournals.humrep.a019459","article-title":"Pregnancy and birth in an in-vitro fertilization cycle after controlled ovarian stimulation in a women with a history of allergic reaction to human menopausal gonadotrophin","volume":"11","author":"Albano","year":"1996","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD010290.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1472-6483(10)62135-9","article-title":"FSH isoform composition of commercial gonadotrophin preparations: a neglected aspect?","volume":"9","author":"Andersen","year":"2004","journal-title":"Reproductive Biomedicine Online"},{"issue":"2","key":"10.1002\/14651858.CD010290.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0304-4157(88)90012-3","article-title":"Pituitary glycoprotein hormone oligosaccharides: structure, synthesis and function of asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin","volume":"947","author":"Baenziger","year":"1988","journal-title":"Biochimica et Biophysica Acta"},{"issue":"1-2","key":"10.1002\/14651858.CD010290.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mce.2012.10.008","article-title":"Ovulation induction in the management of anovulatory polycystic ovary syndrome","volume":"373","author":"Balen","year":"2013","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"6","key":"10.1002\/14651858.CD010290.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1093\/humrep\/14.6.1418","article-title":"What are the clinical benefits of recombinant gonadotrophins? Recombinant follicle stimulating hormone","volume":"14","author":"Bergh","year":"1999","journal-title":"Human Reproduction"},{"issue":"10","key":"10.1002\/14651858.CD010290.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/oxfordjournals.humrep.a138345","article-title":"Allergenic potential of gonadotrophic preparations in experimental animal: Relevance of purity","volume":"9","author":"Biffoni","year":"1994","journal-title":"Human Reproduction"},{"issue":"5","key":"10.1002\/14651858.CD010290.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/molehr\/2.5.361","article-title":"Structure-function relationship of recombinant follicle stimulating hormone (Puregon)","volume":"2","author":"Leeuw","year":"1996","journal-title":"Molecular Human Reproduction"},{"issue":"6","key":"10.1002\/14651858.CD010290.pub2-BIB0027|cit27","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001122.pub4","article-title":"Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome","author":"Farquhar","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD010290.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1210\/jcem-18-12-1333","article-title":"Clinical effect of human pituitary follicle-stimulating hormone (FSH)","volume":"18","author":"Gemzell\u00a0CA","year":"1958","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00006254-198906000-00004","article-title":"Ovarian hyperstimulation syndrome: an update review","volume":"44","author":"Golan","year":"1989","journal-title":"Obstetrical & Gynecological Survey"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0030|cit30","first-page":"20","article-title":"Glycoprotein gonadotrophins. Structure and synthesis","volume":"288","author":"Gray","year":"1988","journal-title":"Acta Endocrinologica. Supplementum"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1432-1033.1990.tb19332.x","article-title":"Isolation and structure determination of the intact sialylated N-linked carbohydrate chains of recombinant human follitropin (hFSH) expressed in Chinese Hamster ovary cells","volume":"193","author":"Hard","year":"1990","journal-title":"European Journal of Biochemistry"},{"issue":"7414","key":"10.1002\/14651858.CD010290.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0033|cit33","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"2","key":"10.1002\/14651858.CD010290.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/humupd\/2.2.172","article-title":"Genetic engineering of human FSH (Gonal F)","volume":"2","author":"Howles","year":"1996","journal-title":"Human Reproduction Update"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0035|cit35","article-title":"Gonadotrophin therapy","volume-title":"Female Infertility","author":"Jewelewicz","year":"1973"},{"issue":"9","key":"10.1002\/14651858.CD010290.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1016\/S0021-9258(18)83656-0","article-title":"Expression of biologically active human follitropin in Chinese hamster ovary cells","volume":"264","author":"Keene","year":"1989","journal-title":"Journal of Biological Chemistry"},{"issue":"7","key":"10.1002\/14651858.CD010290.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/oxfordjournals.humrep.a136208","article-title":"In-vitro biopotency and glycoform distribution of recombinant human follicle stimulating hormone (Org 32489), Metrodin and Metrodin-HP","volume":"10","author":"Lambert","year":"1995","journal-title":"Human Reproduction"},{"issue":"7400","key":"10.1002\/14651858.CD010290.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1136\/bmj.326.7400.1167","article-title":"Pharmaceutical industry sponsorship and research outcome and quality: systematic review","volume":"326","author":"Lexchin","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0039|cit39","first-page":"213","article-title":"Effetti clinici della gonadotropina umana della post-menopausa","volume":"59","author":"Lunenfeld","year":"1960","journal-title":"La Rassegna di Clinica, Terapia e Scienze Affini"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0040|cit40","first-page":"205","article-title":"Review of the safety, efficacy, costs and patient acceptability of recombinant follicle-stimulating hormone for injection in assisting ovulation induction in infertile women","volume":"1","author":"Nahuis","year":"2009","journal-title":"International Journal of Women's Health"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Human Reproduction"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertility and Sterility"},{"issue":"Part 3","key":"10.1002\/14651858.CD010290.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/bj2870665","article-title":"Molecular structures of glycoprotein hormones and functions of their carbohydrate components","volume":"287","author":"Stockell Hartree","year":"1992","journal-title":"Biochemical Journal"},{"issue":"5","key":"10.1002\/14651858.CD010290.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/humrep\/deg133","article-title":"Common statistical errors in the design and analysis of subfertility trials","volume":"18","author":"Vail","year":"2003","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0045|cit45","first-page":"43","article-title":"Isoforms of human gonadotrophins under different physiological conditions","volume-title":"Gonadotrophin Isoforms: Facts and Future","author":"Wide","year":"1997"},{"issue":"1","key":"10.1002\/14651858.CD010290.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1677\/joe.0.1250003","article-title":"Gonadotrophin glycosylation and function","volume":"125","author":"Wilson","year":"1990","journal-title":"Journal of Endocrinology"},{"key":"10.1002\/14651858.CD010290.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2265.1980.tb02132.x","article-title":"The polycystic ovary syndrome","volume":"12","author":"Yen","year":"1980","journal-title":"Clinical Endocrinology"},{"issue":"10","key":"10.1002\/14651858.CD010290.pub2-BIB0048|cit48","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008046.pub4","article-title":"Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology","author":"Youssef","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD010290.pub2-BIB0049|cit49","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002121","article-title":"Recombinant FSH versus urinary gonadotrophins or recombinant FSH for ovulation induction in subfertility associated with polycystic ovary syndrome","author":"Bayram","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD010290.pub2-BIB0050|cit50","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000410","article-title":"Gonadotrophin therapy for ovulation induction in subfertility associated with polycystic ovary syndrome","author":"Nugent","year":"2000","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd010290.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD010290.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T15:16:29Z","timestamp":1653146189000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD010290.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Gynaecology and Fertility Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,9]]},"references-count":50,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd010290.pub2","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD010290.pub3","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,9]]}}}