{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:52:41Z","timestamp":1790610761739,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd010308","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:00:00Z","timestamp":1418947200000}}],"reference-count":81,"publisher":"Wiley","issue":"1","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd010308.pub2","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T17:36:11Z","timestamp":1419010571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Interventions for melanoma in situ, including lentigo maligna"],"prefix":"10.1002","volume":"2016","author":[{"given":"Thrasivoulos","family":"Tzellos","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, University Hospital of North Norway; Department of Dermatology; Harstad Troms Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Kyrgidis","sequence":"additional","affiliation":[{"name":"Dessau Medical Center; Division of Evidence Based Dermatology; Dessau Germany"},{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS); Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova; Reggio Emilia Italy"},{"name":"Aristotle University of Thessaloniki; 1st Department of Otolaryngology, Head & Neck Surgery; 3 Papazoli St. Thessaloniki Greece 54630"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mocellin","sequence":"additional","affiliation":[{"name":"University of Padova; Dept. Surgery Oncology and Gastroenterology; Via Giustiniani 2 Padova Veneto Italy 35128"},{"name":"IOV-IRCCS; Istituto Oncologico Veneto; Padova Italy 35100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Wen","family":"Chan","sequence":"additional","affiliation":[{"name":"University of Toronto; Women's College Research Institute; 790 Bay St, Rm 735 Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Pilati","sequence":"additional","affiliation":[{"name":"University of Padova; Meta-Analysis Unit, Department of Surgery, Oncology and Gastroenterology; via Giustiniani 2 Padova Italy 35128"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Apalla","sequence":"additional","affiliation":[{"name":"Hospital of Skin and Venereal Diseases; State Clinic of Dermatology; 17, Omirou street Thessaloniki Greece 55535"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,19]]},"reference":[{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1001\/archdermatol.2012.270","article-title":"A Randomized Trial of the Off-Label Use of Imiquimod, 5%, Cream with vs without Tazarotene, 0.1%, Gel for the Treatment of Lentigo Maligna, Followed by Conservative Staged Excisions","volume":"148","author":"Hyde","year":"2012","journal-title":"Archives of Dermatology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jss.2007.04.004","article-title":"Factors associated with improved survival among young adult melanoma patients despite a greater incidence of sentinel lymph node metastasis","volume":"143","author":"Chagpar","year":"2007","journal-title":"Journal of Surgical Research"},{"issue":"8","key":"10.1002\/14651858.CD010308.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/cncr.11272","article-title":"Surgical margins in cutaneous melanoma (2 cm versus 5 cm for lesions measuring less than 2.1-mm thick): Long-term results of a large European multicentric phase III study","volume":"97","author":"Khayat","year":"2003","journal-title":"Cancer"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.bjc.6604482","article-title":"Phase II trial of imatinib mesylate in patients with metastatic melanoma","volume":"99","author":"Kim","year":"2008","journal-title":"British Journal of Cancer"},{"issue":"3","key":"10.1002\/14651858.CD010308.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jaad.2008.08.001","article-title":"A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers","volume":"60","author":"Morganroth","year":"2009","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0006|cit6","first-page":"31","article-title":"Adjuvant therapy with recombinant alpha-interferon in non metastatic melanoma","volume":"129","author":"Amatetti","year":"1994","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"issue":"2 Suppl 2","key":"10.1002\/14651858.CD010308.pub2-BIB0007|cit7","doi-asserted-by":"publisher","first-page":"AB145","DOI":"10.1016\/j.jaad.2006.10.672","article-title":"A Prospective Randomized Study Comparing the Efficacy of Horizontal Mohs Tissue Processing to Vertical Breadloaf Tissue Processing in the Surgical Management of Superficial Melanoma","volume":"56","author":"Foster","year":"2007","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.1002\/14651858.CD010308.pub2-BIB0008|cit8","unstructured":"NCT01720407 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face (ImiReduc) clinicaltrials.gov\/show\/NCT01720407"},{"issue":"2","key":"10.1002\/14651858.CD010308.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0304-3835(96)04185-7","article-title":"Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro","volume":"103","author":"Addo-Boadu","year":"1996","journal-title":"Cancer Letters"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1067\/mjd.2002.124085","article-title":"Histologic evaluation of lentigo maligna with permanent sections: implications regarding current guidelines","volume":"47","author":"Agarwal-Antal","year":"2002","journal-title":"Journal of American Academy of Dermatology"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1634\/theoncologist.8-5-459","article-title":"The melanoma epidemic: res ipsa loquitur","volume":"8","author":"Beddingfield\u00a0FC","year":"2003","journal-title":"Oncologist"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jaad.2011.04.031","article-title":"Guidelines of care for the management of primary cutaneous melanoma. American Academy of Dermatology","volume":"65","author":"Bichakjian","year":"2011","journal-title":"Journal of American Academy of Dermatology"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/path.1061","article-title":"Inter-observer variation in the histopathological diagnosis of clinically suspicious pigmented skin lesions","volume":"196","author":"Brochez","year":"2002","journal-title":"Journal of Pathology"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1001\/archderm.140.5.552","article-title":"Management of lentigo maligna and lentigo maligna melanoma with staged excision: a 5-year follow-up","volume":"140","author":"Bub","year":"2004","journal-title":"Archives of Dermatology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1001\/archderm.141.6.723","article-title":"Variation in the diagnosis, treatment, and management of melanoma in situ: a survey of US dermatologists","volume":"141","author":"Charles","year":"2005","journal-title":"Archives of Dermatology"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0046-8177(86)80032-6","article-title":"The biologic forms of malignant melanoma","volume":"17","author":"Clark","year":"1986","journal-title":"Human Pathology"},{"issue":"3","key":"10.1002\/14651858.CD010308.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/107327480801500304","article-title":"Surgical management of melanoma in situ on chronically sun damaged skin","volume":"15","author":"Clark","year":"2008","journal-title":"Cancer Control"},{"issue":"2","key":"10.1002\/14651858.CD010308.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0733-8635(05)70268-0","article-title":"Dermatoscopy of lentigo maligna","volume":"19","author":"Cognetta","year":"2001","journal-title":"Dermatologic Clinics"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0190-9622(95)90282-1","article-title":"Lentigo maligna and lentigo maligna melanoma","volume":"33","author":"Cohen","year":"1995","journal-title":"Journal of American Academy of Dermatology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1524-4725.1998.tb04226.x","article-title":"Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. A follow-up study","volume":"24","author":"Cohen","year":"1998","journal-title":"Dermatologic Surgery"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1524-4725.1980.tb00900.x","article-title":"Treatment of lentigo maligna and lentigo maligna melanoma","volume":"6","author":"Coleman","year":"1980","journal-title":"Journal\u00a0of Dermatologic Surgery &\u00a0Oncology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2230.1991.tb01229.x","article-title":"Cryotherapy for lentigo maligna","volume":"16","author":"Collins","year":"1991","journal-title":"Clinical & Experimental Dermatology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10552-005-3637-4","article-title":"Trends for in situ and invasive melanoma in Queensland, Australia, 1982-2002","volume":"17","author":"Coory","year":"2006","journal-title":"Cancer Causes & Control"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0024|cit24","first-page":"395","article-title":"Mohs surgery for the treatment of melanoma in situ: a review","volume":"33","author":"Dawn","year":"2007","journal-title":"Dermatologic Surgery"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1524-4725.2011.02194.x","article-title":"Basic\u00a0pharmacology\u00a0of topical imiquimod,\u00a05-fluorouracil, and diclofenac for the dermatologic surgeon","volume":"38","author":"Desai","year":"2012","journal-title":"Dermatological Surgery"},{"issue":"7109","key":"10.1002\/14651858.CD010308.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-4632.2010.04423.x","article-title":"Treatment options in melanoma in situ: topical and radiation therapy, excision and Mohs surgery","volume":"49","author":"Erickson","year":"2010","journal-title":"International Journal of Dermatology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0046-8177(96)90157-4","article-title":"Discordance in the histopathologic diagnosis of melanoma and melanocytic nevi between expert pathologists","volume":"27","author":"Farmer","year":"1996","journal-title":"Human Pathology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1046\/j.1365-2133.2002.04750.x","article-title":"A retrospective study of 150 patients with lentigo maligna and lentigo maligna melanoma and the efficacy of radiotherapy using Grenz or soft X-rays","volume":"146","author":"Farshad","year":"2002","journal-title":"British Journal of Dermatology"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/0190-9622(95)90386-0","article-title":"Cryosurgery for lentigo maligna","volume":"32","author":"Field","year":"1995","journal-title":"Journal of American Academy of Dermatology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/bjd.12611","article-title":"Radiotherapy for lentigo maligna: a literature review and recommendations for treatment","volume":"170","author":"Fogarty","year":"2014","journal-title":"British Journal of Dermatology"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0011-2240(79)90048-8","article-title":"Sensitivity of pigmented mucosa and skin to freezing injury","volume":"16","author":"Gage","year":"1979","journal-title":"Cryobiology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/CMR.0b013e3282f0c893","article-title":"Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma","volume":"18","author":"Garbe","year":"2008","journal-title":"Melanoma Research"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-0960.1997.tb01089.x","article-title":"Treatment of lentigo maligna","volume":"38","author":"Gaspar","year":"1997","journal-title":"Australasian Journal of Dermatology"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/120347540400800504","article-title":"Viral and nonviral uses of imiquimod: a review","volume":"8","author":"Gupta","year":"2004","journal-title":"Journal of Cutaneous Medicine & Surgery"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/ijc.10976","article-title":"Incidence trends and familial risks in invasive and in situ cutaneous melanoma by sun-exposed body sites","volume":"104","author":"Hemminki","year":"2003","journal-title":"International Journal of Cancer"},{"key":"10.1002\/14651858.CD010308.pub2-BIB0037|cit37","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1440-0960.1999.00311.x","article-title":"Surgical treatment of lentigo maligna and lentigo maligna melanoma","volume":"40","author":"Hill","year":"1999","journal-title":"Australasian Journal of Dermatology"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1097\/01.prs.0000279324.35616.72","article-title":"Immediate, optimal reconstruction of facial lentigo maligna and melanoma following total peripheral margin control","volume":"120","author":"Jejurikar","year":"2007","journal-title":"Plastic & Reconstructive Surgery"},{"issue":"5 Pt 1","key":"10.1002\/14651858.CD010308.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0190-9622(97)70114-2","article-title":"Usefulness of the staged excision for lentigo maligna and lentigo maligna melanoma: the \u201csquare\u201d procedure","volume":"37","author":"Johnson","year":"1997","journal-title":"Journal of American Academy of Dermatology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/jid.2008.184","article-title":"Imiquimod, a Toll-like receptor 7 agonist, inhibits melanogenesis and proliferation of human melanocytes","volume":"129","author":"Kang","year":"2009","journal-title":"Journal of Investigative Dermatology"},{"issue":"10","key":"10.1002\/14651858.CD010308.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/modpathol.3800454","article-title":"Lentiginous melanoma: a histologic pattern of melanoma to be distinguished from lentiginous nevus","volume":"18","author":"King","year":"2005","journal-title":"Modern Pathology"},{"issue":"7","key":"10.1002\/14651858.CD010308.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1600-0625.2011.01279.x","article-title":"Clinical application of multiphoton tomography in combination with confocal laser scanning microscopy for in vivo evaluation of skin diseases","volume":"20","author":"Koehler","year":"2011","journal-title":"Experimental Dermatology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/archderm.1995.01690180115026","article-title":"Treatment of lentigo maligna with the carbon dioxide laser","volume":"131","author":"Kopera","year":"1995","journal-title":"Archives of Dermatology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0190-9622(94)70139-3","article-title":"Cryosurgery for lentigo maligna","volume":"31","author":"Kuflik","year":"1994","journal-title":"Journal of American Academy of Dermatology"},{"issue":"3","key":"10.1002\/14651858.CD010308.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jaad.2011.06.019","article-title":"Surgical margins for melanoma in situ","volume":"66","author":"Kunishige","year":"2012","journal-title":"Journal of American Academy of Dermatology"},{"issue":"2","key":"10.1002\/14651858.CD010308.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/archdermatol.2011.291","article-title":"Risk Factors for Lentigo Maligna Melanoma Compared With Superficial Spreading Melanoma: A Case-Control Study in Australia","volume":"148","author":"Kvaskoff","year":"2012","journal-title":"Archives of Dermatology"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1440-0960.2008.00468.x","article-title":"Treatment of lentigo maligna with total circumferential margin control using vertical and horizontal permanent sections: a retrospective study","volume":"49","author":"Lee","year":"2008","journal-title":"Australasian Journal of Dermatology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1001\/archfaci.2011.66","article-title":"Carbon dioxide\u00a0laser\u00a0treatment for\u00a0lentigo maligna: a retrospective review comparing 3 different treatment modalities","volume":"13","author":"Lee","year":"2011","journal-title":"Archives of\u00a0Facial Plastic Surgery"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/1523-1747.ep12277084","article-title":"Inhibition of DNA synthesis of melanoma cells by azelaic acid","volume":"85","author":"Leibl","year":"1985","journal-title":"Journal of Investigative Dermatology"},{"issue":"3","key":"10.1002\/14651858.CD010308.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/1097-0142(197503)35:3<721::AID-CNCR2820350327>3.0.CO;2-#","article-title":"Topical chemotherapy of\u00a0lentigo maligna\u00a0with 5-fluorouracil","volume":"35","author":"Litwin","year":"1975","journal-title":"Cancer"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1524-4725.2009.01099.x","article-title":"Lentigo maligna-outcomes of treatment with Q-switched Nd:YAG and alexandrite lasers","volume":"35","author":"Madan","year":"2009","journal-title":"Dermatological Surgery"},{"issue":"2","key":"10.1002\/14651858.CD010308.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jso.20284","article-title":"The perimeter technique for lentigo maligna: an alternative to Mohs micrographic surgery","volume":"91","author":"Mahoney","year":"2005","journal-title":"Journal of Surgical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0054|cit54","first-page":"493","article-title":"Lentigo maligna\/lentigo maligna melanoma: current stage of diagnosis and treatment","volume":"32","author":"McKenna","year":"2006","journal-title":"Dermatological Surgery"},{"key":"10.1002\/14651858.CD010308.pub2-BIB0055|cit55","doi-asserted-by":"crossref","unstructured":"McLeod M Choudhary S Giannakakis G Nouri K Surgical Treatments for Lentigo Maligna: A Review Dermatologic Surgery 2011 1210 28 21631635","DOI":"10.1111\/j.1524-4725.2011.02042.x"},{"issue":"9321","key":"10.1002\/14651858.CD010308.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(02)08741-X","article-title":"Reliability of diagnosis of melanoma in situ","volume":"359","author":"Megahed","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD010308.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jaad.2013.11.008","article-title":"Incidence of lentigo maligna in Olmsted County, Minnesota, 1970 to 2007","volume":"70","author":"Mirzoyev","year":"2014","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1634\/theoncologist.2010-0340","article-title":"Cutaneous melanoma in situ: translational evidence from a large population-based study","volume":"16","author":"Mocellin\u00a0S","year":"2011","journal-title":"Oncologist"},{"issue":"2","key":"10.1002\/14651858.CD010308.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/archsurg.1941.01210080079004","article-title":"Chemosurgery: a microscopically controlled method of cancer excision","volume":"42","author":"Mohs","year":"1941","journal-title":"Archives of Surgery"},{"key":"10.1002\/14651858.CD010308.pub2-BIB0060|cit60","unstructured":"National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology: Melanoma www.nccn.org\/professionals\/physician_gls\/PDF\/melanoma.pdf"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00000372-199302000-00006","article-title":"National Institutes of Health Consensus Development Conference Statement on Diagnosis and Treatment of Early Melanoma, January 27-29, 1992","volume":"15","author":"National Institutes of Health","year":"1993","journal-title":"American Journal of Dermatopathology"},{"issue":"8","key":"10.1002\/14651858.CD010308.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1054\/bjps.2002.3967","article-title":"A follow-up study to investigate the efficacy of initial treatment of lentigo maligna with surgical excision","volume":"55","author":"Osborne","year":"2002","journal-title":"British Journal of Plastic Surgery"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2133.2006.07476.x","article-title":"Imiquimod in the treatment of lentigo maligna","volume":"155","author":"Rajpar","year":"2006","journal-title":"British Journal of Dermatology"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-4632.2005.02582.x","article-title":"Successful treatment of malignant melanoma in situ with topical 5% imiquimod cream","volume":"44","author":"Ray","year":"2005","journal-title":"International Journal of Dermatology"},{"key":"10.1002\/14651858.CD010308.pub2-BIB0065|cit65","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"5","key":"10.1002\/14651858.CD010308.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-4362.1993.tb01475.x","article-title":"Treatment of lentigo maligna with azelaic acid","volume":"32","author":"Rodriguez Prieto","year":"1993","journal-title":"International Journal of Dermatology"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jso.2930380409","article-title":"A role for topical 5-fluorouracil therapy in melanoma","volume":"38","author":"Ryan","year":"1988","journal-title":"Journal of Surgical Oncology"},{"issue":"1 Pt 1","key":"10.1002\/14651858.CD010308.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0190-9622(00)90005-7","article-title":"Improvement of early recognition of lentigo maligna using dermatoscopy","volume":"42","author":"Schiffner","year":"2000","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"3","key":"10.1002\/14651858.CD010308.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1067\/mjd.2000.106241","article-title":"Fractionated radiotherapy of lentigo maligna and lentigo maligna melanoma in 64 patients","volume":"43","author":"Schmid-Wendtner","year":"2000","journal-title":"Journal of American Academy of Dermatology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0190-9622(98)70405-0","article-title":"Mohs micrographic surgery","volume":"39","author":"Shriner","year":"1998","journal-title":"Journal of American Academy of Dermatology"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0071|cit71","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004835.pub2","article-title":"Surgical excision margins for primary cutaneous melanoma","author":"Sladden","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD010308.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2165\/00128071-200506030-00002","article-title":"Lentigo maligna: prognosis and treatment options","volume":"6","author":"Stevenson","year":"2005","journal-title":"American Journal of Clinical Dermatology"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.0022-202X.2005.23852.x","article-title":"Increasing\u00a0incidence\u00a0of\u00a0lentigo\u00a0maligna\u00a0melanoma\u00a0subtypes:\u00a0northern\u00a0California\u00a0and\u00a0national trends\u00a01990-2000","volume":"125","author":"Swetter","year":"2005","journal-title":"Journal of Investigative Dermatology"},{"issue":"6","key":"10.1002\/14651858.CD010308.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1053\/hupa.2000.7640","article-title":"Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type","volume":"31","author":"Tannous","year":"2000","journal-title":"Human Pathology"},{"issue":"8","key":"10.1002\/14651858.CD010308.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/archderm.1994.01690080074010","article-title":"Lentigo maligna of the head and neck: results of treatment by radiotherapy","volume":"130","author":"Tsang","year":"1994","journal-title":"Archives of Dermatology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1742-1241.2002.tb11196.x","article-title":"Recurrent lentigo maligna melanoma: regression associated with local azelaic acid 20%","volume":"56","author":"Vereecken","year":"2002","journal-title":"International Journal of Clinical Practice"},{"issue":"4","key":"10.1002\/14651858.CD010308.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jaad.2007.02.011","article-title":"Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma","volume":"57","author":"Walling","year":"2007","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"3","key":"10.1002\/14651858.CD010308.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2133.1987.tb05843.x","article-title":"The risk of progression of lentigo maligna to lentigo maligna melanoma","volume":"116","author":"Weinstock","year":"1987","journal-title":"British Journal of Dermatology"},{"issue":"8","key":"10.1002\/14651858.CD010308.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/j.1524-4725.2009.01227.x","article-title":"Recurrence of lentigo maligna and development of invasive melanoma after treatment of lentigo maligna with imiquimod","volume":"35","author":"Woodmansee","year":"2009","journal-title":"Dermatologic Surgery"},{"issue":"2 Pt 1","key":"10.1002\/14651858.CD010308.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0190-9622(97)80131-4","article-title":"Mohs micrographic surgery for the treatment of primary cutaneous melanoma","volume":"37","author":"Zitelli","year":"1997","journal-title":"Journal of American Academy of Dermatology"},{"issue":"1","key":"10.1002\/14651858.CD010308.pub2-BIB0081|cit81","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010308","article-title":"Interventions for melanoma in situ, including lentigo maligna","author":"Apalla","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD010308.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T08:37:25Z","timestamp":1690274245000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD010308.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Skin Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,19]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd010308.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,19]]}}}