{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:36:38Z","timestamp":1790426198198,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd010331","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:00:00Z","timestamp":1486166400000}}],"reference-count":77,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd010331.pub2","type":"journal-article","created":{"date-parts":[[2017,2,5]],"date-time":"2017-02-05T04:30:06Z","timestamp":1486269006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Topical anaesthesia for needle-related pain in newborn infants"],"prefix":"10.1002","volume":"2017","author":[{"given":"Jann P","family":"Foster","sequence":"first","affiliation":[{"name":"University of Sydney; School of Nursing and Midwifery; Penrith DC Australia"},{"name":"Western Sydney University; Sydney Nursing School\/Central Clinical School, Discipline of Obstetrics, Gynaecology and Neonatology; Sydney Australia"},{"name":"Ingham Research Institute; Liverpool NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Western Sydney; Parramatta Campus, Bldg EI G15 Locked Bag 1797 Penrith NSw Australia 2751"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaye","family":"Spence","sequence":"additional","affiliation":[{"name":"The Children's Hospital at Westmead; Grace Centre for Newborn Care; Locked Bag 4001 Westmead NSW Australia 2145"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,4]]},"reference":[{"issue":"5","key":"10.1002\/14651858.CD010331.pub2-BIB0001|cit1","first-page":"392","article-title":"Pain prevention in term neonates: randomised trial for three methods","volume":"106","author":"Bonetto","year":"2008","journal-title":"Archives of Argentine Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"F207","DOI":"10.1136\/fn.83.3.F207","article-title":"Does topical amethocaine gel reduce the pain of venepuncture in newborn infants? A randomised double blind controlled trial","volume":"83","author":"Jain","year":"2000","journal-title":"Archives of Disease in Childhood Fetal and Neonatal Edition"},{"issue":"11","key":"10.1002\/14651858.CD010331.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1001\/archpedi.157.11.1065","article-title":"A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns","volume":"157","author":"Kaur","year":"2003","journal-title":"Archives of Pediatric and Adolescent Medicine"},{"issue":"8","key":"10.1002\/14651858.CD010331.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1399-6576.1995.tb04223.x","article-title":"Does a local anaesthetic cream (EMLA) alleviate pain from heel-lancing in neonates?","volume":"39","author":"Larsson","year":"1995","journal-title":"Acta Anaesthesiologica Scandinavica"},{"issue":"7","key":"10.1002\/14651858.CD010331.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1651-2227.1998.tb01746.x","article-title":"Alleviation of the pain of venepuncture in neonates","volume":"87","author":"Larsson","year":"1998","journal-title":"Acta Paediatrica"},{"issue":"4","key":"10.1002\/14651858.CD010331.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/bja\/aeg216","article-title":"Randomized trial of novel tetracaine patch to provide local anaesthesia in neonates undergoing venepuncture","volume":"91","author":"Long","year":"2003","journal-title":"British Journal of Anaesthesia"},{"issue":"1","key":"10.1002\/14651858.CD010331.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.clinthera.2008.01.018","article-title":"Topical Amethocaine gel 4% for intramuscular injection in term neonates: a double-blind, placebo-controlled, randomized trial","volume":"30","author":"Shah","year":"2008","journal-title":"Clinical Therapeutics"},{"issue":"4","key":"10.1002\/14651858.CD010331.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00004703-199908000-00003","article-title":"Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants?","volume":"20","author":"Stevens","year":"1999","journal-title":"Developmental and Behavioral Pediatrics"},{"issue":"2","key":"10.1002\/14651858.CD010331.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1651-2227.2001.tb00278.x","article-title":"Oral sucrose compares favourably with lidocaine-prilocaine cream for pain during venepuncture in neonates","volume":"90","author":"Abad","year":"2001","journal-title":"Acta Paediatrica"},{"issue":"2","key":"10.1002\/14651858.CD010331.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"F138","DOI":"10.1136\/fn.78.2.F138","article-title":"Randomised controlled trial of eutectic mixture of local anaesthetics cream for venepuncture in healthy preterm infants","volume":"78","author":"Acharya","year":"1998","journal-title":"Archives of Disease in Childhood Fetal and Neonatal Edition"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0011|cit11","first-page":"286","article-title":"Neonatal circumcision: with or without anaesthesia","volume":"25","author":"Ahmed","year":"2009","journal-title":"Pakistan Journal of Surgery"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/bja\/aen003","article-title":"Topical anaesthesia and intravenous cannulation success in paediatric patients: a randomized double-blind trial","volume":"100","author":"Arendts","year":"2008","journal-title":"British Journal of Anaesthesia"},{"issue":"6","key":"10.1002\/14651858.CD010331.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.adnc.2003.09.006","article-title":"A randomized controlled trial evaluating the efficacy of tetracaine gel for pain relief from peripherally inserted central catheters in infants","volume":"3","author":"Ballantyne","year":"2003","journal-title":"Advances in Neonatal Care"},{"issue":"7","key":"10.1002\/14651858.CD010331.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1001\/jama.1993.03510070072039","article-title":"Topical anesthesia during circumcision in the newborn","volume":"270","author":"Benini","year":"1993","journal-title":"JAMA"},{"issue":"1","key":"10.1002\/14651858.CD010331.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1542\/peds.2010-1287","article-title":"Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants","volume":"128","author":"Biran","year":"2011","journal-title":"Pediatrics"},{"issue":"11","key":"10.1002\/14651858.CD010331.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/j.1651-2227.1998.tb00929.x","article-title":"Methaemoglobin formation after the use of EMLA cream in term infants","volume":"87","author":"Brisman","year":"1998","journal-title":"Acta Paediatrica"},{"issue":"9","key":"10.1002\/14651858.CD010331.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1651-2227.1999.tb00190.x","article-title":"Comparison of lignocaine-prilocaine cream and amethocaine gel for local analgesia before venepuncture in children","volume":"88","author":"Choy","year":"1999","journal-title":"Acta Paediatrica"},{"issue":"11","key":"10.1002\/14651858.CD010331.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/adc.61.11.1132","article-title":"Topical anaesthesia for venepuncture","volume":"61","author":"Clarke","year":"1986","journal-title":"Archives of Disease in Childhood"},{"issue":"5","key":"10.1002\/14651858.CD010331.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s004310051106","article-title":"Safety of lidocaine-prilocaine cream application four times a day in premature neonates: a pilot study","volume":"158","author":"Essink-Tebbes","year":"1999","journal-title":"European Journal of Pediatrics"},{"issue":"11","key":"10.1002\/14651858.CD010331.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0929-693X(96)81278-4","article-title":"Use of EMLA cream in premature and full-term newborn infants. Study of efficacy and tolerance","volume":"2","author":"Gourrier","year":"1995","journal-title":"Archives of Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"F211","DOI":"10.1136\/fn.83.3.F211","article-title":"Topical amethocaine gel in the newborn infant: how soon does it work and how long does it last?","volume":"83","author":"Jain","year":"2000","journal-title":"Archives of Disease in Childhood Fetal and Neonatal Edition"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0891-5245(01)45632-X","article-title":"Evaluation of pain management interventions for neonatal circumcision pain","volume":"15","author":"Joyce","year":"2001","journal-title":"Journal of Pediatric Health Care"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"e532","DOI":"10.5812\/ijp.25(3)2015.532","article-title":"The effects of instrumental touching on infant pain perception and the effects of eutectic mixture of local anesthetics (EMLA) on the reduction of pain","volume":"25","author":"Kucukoglu","year":"2015","journal-title":"Iran Journal of Pediatrics"},{"issue":"6","key":"10.1002\/14651858.CD010331.pub2-BIB0024|cit24","first-page":"397","article-title":"Venepuncture pain can be reduced","volume":"88","author":"Kurien","year":"1985","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2431-7-7","article-title":"How effective is tetracaine 4% gel, before venipuncture, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial","volume":"7","author":"Lemyre","year":"2007","journal-title":"BMC Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0304-3959(00)00252-9","article-title":"Assessment of the effect of EMLA during venipuncture in the newborn by analysis of heart rate variability","volume":"86","author":"Lindh","year":"2000","journal-title":"Pain"},{"issue":"6","key":"10.1002\/14651858.CD010331.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"F467","DOI":"10.1136\/adc.2011.215152","article-title":"EMLA versus glucose for PICC insertion: a randomised-triple masked controlled study","volume":"96","author":"Marcatto","year":"2011","journal-title":"Archives of Disease in Childhood Fetal & Neonatal Edition"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"F177","DOI":"10.1136\/fn.70.3.F177","article-title":"Alleviation of the pain of heel prick in preterm infants","volume":"70","author":"McIntosh","year":"1994","journal-title":"Archives of Disease in Childhood"},{"issue":"4","key":"10.1002\/14651858.CD010331.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1046\/j.1365-2648.2001.01776.x","article-title":"No more tears: a randomized controlled double-blind trial of amethocaine gel vs. placebo in the management of procedural pain in neonates","volume":"34","author":"Moore","year":"2001","journal-title":"Journal of Advanced Nursing"},{"issue":"9","key":"10.1002\/14651858.CD010331.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/AJP.0b013e318153497c","article-title":"Effect of eutectic mixture of local anesthetics (EMLA) for pain relief during suprapubic aspiration in young infants: a randomized, controlled trial","volume":"23","author":"Nahum","year":"2007","journal-title":"Clinical Journal of Pain"},{"issue":"7","key":"10.1002\/14651858.CD010331.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/emj.2008.065110","article-title":"Amethocaine versus EMLA for successful intravenous cannulation in a children's emergency departments: a randomised controlled trial","volume":"26","author":"Newbury","year":"2009","journal-title":"Emergency Medicine Journal"},{"issue":"1","key":"10.1002\/14651858.CD010331.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/bja\/64.1.72","article-title":"Inverse relationship between age-dependent erythrocyte activity of methaemoglobin reductase and prilocaine-induced methaemoglobinaemia during infancy","volume":"64","author":"Nilsson","year":"1990","journal-title":"British Journal of Anaesthesia"},{"issue":"6","key":"10.1002\/14651858.CD010331.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0022-3476(05)82220-6","article-title":"Assessing pain and analgesia with a lidocaine-prilocaine emulsion in infants and toddlers during venipuncture","volume":"118","author":"Robieux","year":"1991","journal-title":"Journal of Pediatrics"},{"issue":"6","key":"10.1002\/14651858.CD010331.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0022-3476(95)70050-1","article-title":"Safety of lidocaine-prilocaine cream in the treatment of preterm infants","volume":"127","author":"Taddio","year":"1995","journal-title":"Journal of Pediatrics"},{"issue":"7","key":"10.1002\/14651858.CD010331.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/jama.295.7.793","article-title":"Intravenous morphine and topical tetracaine for treatment of pain in preterm neonates undergoing central line placement","volume":"295","author":"Taddio","year":"2006","journal-title":"Journal of the American Medical Association"},{"issue":"4","key":"10.1002\/14651858.CD010331.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/ajhp\/54.4.388","article-title":"Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children","volume":"54","author":"Kan","year":"1997","journal-title":"American Journal of Health-System Pharmacy"},{"issue":"5","key":"10.1002\/14651858.CD010331.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1542\/peds.92.5.710","article-title":"Safety and efficacy of a topical anesthetic for neonatal circumcision","volume":"92","author":"Weatherstone","year":"1993","journal-title":"Pediatrics"},{"issue":"21","key":"10.1002\/14651858.CD010331.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJM198711193172105","article-title":"Pain and its effects in the human neonate and fetus","volume":"317","author":"Anand","year":"1987","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD010331.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000014197","article-title":"Can adverse neonatal experiences alter brain development and subsequent behaviour?","volume":"77","author":"Anand","year":"2000","journal-title":"Biology of the Neonate"},{"issue":"2","key":"10.1002\/14651858.CD010331.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/archpedi.155.2.173","article-title":"International Evidence-Based Group for Neonatal Pain. Consensus statement for the prevention and management of pain in the newborn","volume":"155","author":"Anand","year":"2001","journal-title":"Archives of Pediatrics & Adolescent Medicine"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0041|cit41","unstructured":"AstraZeneca EMLA, 2008 www.astrazeneca.com.au\/healthcare-professionals\/product-information"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0042|cit42","first-page":"9","article-title":"The National Pain Management Guideline: implications for neonatal intensive care. Agency for Health Care Policy and Research","volume":"13","author":"Bell","year":"1994","journal-title":"Neonatal Network - Journal of Neonatal Nursing"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0043|cit43","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004217.pub2","article-title":"Pain relief for neonatal circumcision","author":"Brady-Fryer","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD010331.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/BF03013194","article-title":"Topical amethocaine (Ametop) is superior to EMLA for intravenous cannulation. Eutectic mixture of local anesthetics","volume":"46","author":"Browne","year":"1999","journal-title":"Canadian Journal of Anaesthesia"},{"issue":"2","key":"10.1002\/14651858.CD010331.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jen.2006.11.007","article-title":"Methemoglobinemia","volume":"33","author":"Camp","year":"2007","journal-title":"Journal of Emergency Nursing"},{"issue":"6","key":"10.1002\/14651858.CD010331.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2165\/00002018-199614060-00005","article-title":"Drug induced methaemoglobinaemia. Treatment issues","volume":"14","author":"Coleman","year":"1996","journal-title":"Drug Safety"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/107385840100700309","article-title":"The neurobiology of pain: developmental aspects","volume":"7","author":"Fitzgerald","year":"2001","journal-title":"Neuroscientist"},{"issue":"5","key":"10.1002\/14651858.CD010331.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1365-2648.2007.04547.x","article-title":"Parental stress and satisfaction in the non-tertiary special care nursery","volume":"61","author":"Foster","year":"2008","journal-title":"Journal of Advanced Nursing"},{"issue":"1","key":"10.1002\/14651858.CD010331.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"F71","DOI":"10.1136\/fn.89.1.F71","article-title":"Parental concern and distress about infant pain","volume":"89","author":"Franck","year":"2004","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0050|cit50","unstructured":"Brozek J Oxman A Sch\u00fcnemann H GRADEpro [Version 3.2 for Windows] 2008"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0304-3959(87)90073-X","article-title":"Pain expression in neonates: facial action and cry","volume":"28","author":"Grunau","year":"1987","journal-title":"Pain"},{"issue":"4","key":"10.1002\/14651858.CD010331.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"4","key":"10.1002\/14651858.CD010331.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jclinepi.2010.07.017","article-title":"GRADE guidelines: 4. Rating the quality of evidence - study limitations (risk of bias)","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"12","key":"10.1002\/14651858.CD010331.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jclinepi.2011.03.017","article-title":"GRADE guidelines: 7. Rating the quality of evidence - inconsistency","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"12","key":"10.1002\/14651858.CD010331.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.jclinepi.2011.01.012","article-title":"GRADE guidelines 6. Rating the quality of evidence - imprecision","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"12","key":"10.1002\/14651858.CD010331.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jclinepi.2011.04.014","article-title":"GRADE guidelines: 8. Rating the quality of evidence - indirectness","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0057|cit57","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"1","key":"10.1002\/14651858.CD010331.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3959(95)00100-X","article-title":"Determinants of success and failure of EMLA","volume":"64","author":"Lander","year":"1996","journal-title":"Pain"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0059|cit59","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004236.pub2","article-title":"EMLA and amethocaine for reduction of children's pain associated with needle insertion","author":"Lander","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD010331.pub2-BIB0060|cit60","first-page":"59","article-title":"The development of a tool to assess neonatal pain","volume":"12","author":"Lawrence","year":"1993","journal-title":"Neonatal Network"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/bja\/75.3.282","article-title":"Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children","volume":"75","author":"Lawson","year":"1995","journal-title":"British Journal of Anaesthesia"},{"issue":"8","key":"10.1002\/14651858.CD010331.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1399-6576.1987.tb02655.x","article-title":"Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication","volume":"31","author":"Manner","year":"1987","journal-title":"Acta Anaesthesiologica Scandinavia"},{"issue":"11","key":"10.1002\/14651858.CD010331.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1093\/bja\/58.11.1242","article-title":"Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children: effect on the pain associated with venous cannulation","volume":"58","author":"Maunuksela","year":"1986","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0064|cit64","unstructured":"The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"4","key":"10.1002\/14651858.CD010331.pub2-BIB0065|cit65","first-page":"308","article-title":"Benzocaine-induced\u00a0methemoglobinemia: a\u00a0potentially\u00a0fatal\u00a0complication\u00a0of\u00a0transesophageal echocardiography","volume":"30","author":"Sachdeva","year":"2003","journal-title":"Texas Heart Institute Journal"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0066|cit66","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G Oxman A (editors) GRADE handbook for grading quality of evidence and strength of recommendations Available from www.guidelinedevelopment.org\/handbook Updated October 2013"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0067|cit67","unstructured":"Smith Nephew Ametop gel, 2012 www.smith-nephew.com\/global\/assets\/en-gb\/pdf\/v1-ametopspc_uk.pdf"},{"issue":"1","key":"10.1002\/14651858.CD010331.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2702.2005.01527.x","article-title":"Nitric oxide and nursing: a review","volume":"16","author":"Stephens","year":"2007","journal-title":"Journal of Clinical Nursing"},{"issue":"1","key":"10.1002\/14651858.CD010331.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00002508-199603000-00004","article-title":"Premature Infant Pain Profile: development and initial validation","volume":"12","author":"Stevens","year":"1996","journal-title":"Clinical Journal of Pain"},{"issue":"2","key":"10.1002\/14651858.CD010331.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.101.2.e1","article-title":"A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates","volume":"101","author":"Taddio","year":"1998","journal-title":"Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD010331.pub2-BIB0071|cit71","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000496","article-title":"Lidocaine-prilocaine cream for analgesia during circumcision in newborn boys","author":"Taddio","year":"1999","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1055\/s-2007-994488","article-title":"Methemoglobinemia associated with prilocaine use in neonatal circumcision","volume":"12","author":"Tse","year":"1995","journal-title":"American Journal of Perinatology"},{"issue":"1","key":"10.1002\/14651858.CD010331.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/59.1.5","article-title":"The toxicology of inhaled nitric oxide therapy","volume":"59","author":"Weinberger","year":"2001","journal-title":"Toxicological Sciences"},{"issue":"2","key":"10.1002\/14651858.CD010331.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0095-5108(05)70026-9","article-title":"Behavior, pain perception, and the extremely low-birth weight survivor","volume":"27","author":"Whitfield","year":"2000","journal-title":"Clinics in Perinatology"},{"issue":"2","key":"10.1002\/14651858.CD010331.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2125.1990.tb03775.x","article-title":"Clinical experiences with a novel percutaneous amethocaine preparation: prevention of pain due to venipuncture in children","volume":"30","author":"Woolfson","year":"1990","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"5","key":"10.1002\/14651858.CD010331.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0196-0644(99)70167-8","article-title":"Methemoglobinemia: etiology, pharmacology, and clinical management","volume":"34","author":"Wright","year":"1999","journal-title":"Annals of Emergency Medicine"},{"key":"10.1002\/14651858.CD010331.pub2-BIB0077|cit77","first-page":"1","article-title":"Clinical update on therapeutic use of nitric oxide","volume":"7","author":"Zaky","year":"2009","journal-title":"Contemporary Critical Care"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD010331.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T06:48:33Z","timestamp":1687157313000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD010331.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Neonatal Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,4]]},"references-count":77,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd010331.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,4]]}}}