{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:50:03Z","timestamp":1767135003414,"version":"build-2238731810"},"update-to":[{"DOI":"10.1002\/14651858.cd010368","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000}}],"reference-count":39,"publisher":"Wiley","issue":"10","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd010368.pub2","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T06:40:54Z","timestamp":1519972854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults"],"prefix":"10.1002","volume":"2018","author":[{"given":"Heinrich","family":"R\u00fcschen","sequence":"first","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust; Department of Anaesthesia; 162 City Road London UK EC1V 2PD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"Aravinth","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust; Department of Anaesthesia; 162 City Road London UK EC1V 2PD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catey","family":"Bunce","sequence":"additional","affiliation":[{"name":"King's College London; Department of Primary Care & Public Health Sciences; 4th Floor, Addison House Guy's Campus London UK SE1 1UL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desta","family":"Bokre","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital & UCL Institute of Ophthalmology; The Joint Library of Ophthalmology; 11-43 Bath Street London UK EC1V 9EL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,2]]},"reference":[{"issue":"Pt 3","key":"10.1002\/14651858.CD010368.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/eye.1997.81","article-title":"Is hyaluronidase helpful for peribulbar anaesthesia?","volume":"11","author":"Bowman","year":"1997","journal-title":"Eye"},{"issue":"11","key":"10.1002\/14651858.CD010368.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1365-2044.1995.tb05940.x","article-title":"An evaluation of two concentrations of hyaluronidase for supplementation of peribulbar anaesthesia","volume":"50","author":"Brydon","year":"1995","journal-title":"Anaesthesia"},{"issue":"8","key":"10.1002\/14651858.CD010368.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/sj.eye.6702860","article-title":"The effect of hyaluronidase on ultrasound-measured dispersal of local anaesthetic following sub-Tenon injection","volume":"22","author":"Khandwala","year":"2008","journal-title":"Eye"},{"issue":"11","key":"10.1002\/14651858.CD010368.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.jcrs.2008.07.022","article-title":"Efficacy and safety of hyaluronidase 75 IU as an adjuvant to mepivacaine for retrobulbar anesthesia in cataract surgery","volume":"34","author":"Remy","year":"2008","journal-title":"Journal of Cataract and Refractive Surgery"},{"issue":"4","key":"10.1002\/14651858.CD010368.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/bjo.84.4.435","article-title":"Sub-Tenon's local anaesthesia: the effect of hyaluronidase","volume":"84","author":"Rowley","year":"2000","journal-title":"British Journal of Ophthalmology"},{"issue":"3","key":"10.1002\/14651858.CD010368.pub2-BIB0006|cit6","first-page":"389","article-title":"Hyaluronidase in subTenon's anaesthesia for phacoemulsification, a double blind randomized clinical trial","volume":"5","author":"Sedghipour","year":"2012","journal-title":"International Journal of Ophthalmology"},{"issue":"5","key":"10.1002\/14651858.CD010368.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1590\/S0004-27492002000500005","article-title":"A comparison of 1% ropivacaine efficacy when associated or not with hyaluronidase in peribulbar anaesthesia in cataract surgery","volume":"65","author":"Shiroma","year":"2002","journal-title":"Arquivos Brasileiros de Oftalmologia"},{"issue":"8","key":"10.1002\/14651858.CD010368.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1034\/j.1399-6576.2001.450807.x","article-title":"Comparison of lignocaine 2% with adrenaline, bupivacaine 0.5% with or without hyaluronidase and a mixture of bupivacaine, lignocaine and hyaluronidase for peribulbar block analgesia","volume":"45","author":"Berg","year":"2001","journal-title":"Acta Anaesthesiologica Scandinavica"},{"issue":"10","key":"10.1002\/14651858.CD010368.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1365-2044.1994.tb04273.x","article-title":"The effect of hyaluronidase on peribulbar block","volume":"49","author":"Crawford","year":"1994","journal-title":"Anaesthesia"},{"issue":"2","key":"10.1002\/14651858.CD010368.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/0310057X9902700209","article-title":"Sub-Tenon's block: the effect of hyaluronidase on speed of onset and block quality","volume":"27","author":"Guise","year":"1999","journal-title":"Anaesthesia and Intensive Care"},{"issue":"1","key":"10.1002\/14651858.CD010368.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0886-3350(13)80989-3","article-title":"Choice of anesthetic agents for peribulbar anesthesia","volume":"17","author":"House","year":"1991","journal-title":"Journal of Cataract and Refractive Surgery"},{"issue":"6","key":"10.1002\/14651858.CD010368.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1755-3768.1993.tb08601.x","article-title":"Retrobulbar anaesthesia: a clinical evaluation of four different anaesthetic mixtures","volume":"71","author":"Johansen","year":"1993","journal-title":"Acta Ophthalmologica"},{"issue":"4","key":"10.1002\/14651858.CD010368.pub2-BIB0013|cit13","first-page":"312","article-title":"Comparison of bupivacaine 0.75% with a mixture of bupivacaine 0.75% and mepivacaine 2% in retrobulbar anaesthesia: effects of hyaluronidase","volume":"86","author":"Lange","year":"1989","journal-title":"Fortschritte der Ophthalmologie"},{"issue":"5","key":"10.1002\/14651858.CD010368.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1034\/j.1399-6576.2002.460519.x","article-title":"Effect of alkalinization and\/or hyaluronidase adjuvancy on a local anesthetic mixture for sub-Tenon's ophthalmic block","volume":"46","author":"Moharib","year":"2002","journal-title":"Acta Anaesthesiologica Scandinavica"},{"issue":"3","key":"10.1002\/14651858.CD010368.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/eye.1992.56","article-title":"The effects of adrenaline, hyaluronidase and age on peribulbar anaesthesia","volume":"6","author":"Morsman","year":"1992","journal-title":"Eye"},{"issue":"4","key":"10.1002\/14651858.CD010368.pub2-BIB0016|cit16","first-page":"S287","article-title":"A study of effect of hyaluronidase on subTenon anaesthesia","volume":"40","author":"Ramanathan","year":"1999","journal-title":"Cataract Surgery and Assessment"},{"issue":"9","key":"10.1002\/14651858.CD010368.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/BF03008340","article-title":"Hyaluronidase improves regional ophthalmic anaesthesia with etidocaine","volume":"39","author":"Sarvela","year":"1992","journal-title":"Canadian Journal of Anaesthesia"},{"issue":"4","key":"10.1002\/14651858.CD010368.pub2-BIB0018|cit18","first-page":"420","article-title":"Peribulbar block with the association of 0.5% enantiomeric mixture of bupivacaine and 2% lignocaine: effects of hyaluronidase addition","volume":"52","author":"Soares","year":"2002","journal-title":"Revista Brasileira de Anestesiologia"},{"issue":"1","key":"10.1002\/14651858.CD010368.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/anae.13730","article-title":"Can systematic reviews with sparse data be trusted?","volume":"72","author":"Afshari","year":"2017","journal-title":"Anaesthesia"},{"issue":"7","key":"10.1002\/14651858.CD010368.pub2-BIB0020|cit20","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004083.pub3","article-title":"Peribulbar versus retrobulbar anaesthesia for cataract surgery","author":"Alhassan","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD010368.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1001\/archopht.1949.00900050638012","article-title":"Use of hyaluronidase with local anaesthesia in ophthalmology; preliminary report","volume":"42","author":"Atkinson","year":"1949","journal-title":"Archives of Ophthalmology"},{"issue":"13","key":"10.1002\/14651858.CD010368.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1016\/S0021-9258(19)34203-6","article-title":"Purification and partial characterization of testicular hyaluronidase","volume":"243","author":"Borders","year":"1968","journal-title":"Journal of Biological Chemistry"},{"issue":"9","key":"10.1002\/14651858.CD010368.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0886-3350(99)00151-0","article-title":"Cluster of diplopia cases after periocular anesthesia without hyaluronidase","volume":"25","author":"Brown","year":"1999","journal-title":"Journal of Cataract and Refractive Surgery"},{"issue":"11","key":"10.1002\/14651858.CD010368.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/S0886-3350(01)01068-9","article-title":"Second cluster of strabismus cases after periocular anesthesia without hyaluronidase","volume":"27","author":"Brown","year":"2001","journal-title":"Journal of Cataract and Refractive Surgery"},{"issue":"5","key":"10.1002\/14651858.CD010368.pub2-BIB0025|cit25","article-title":"Hyaluronidase: from clinical applications to molecular and cellular mechanisms","volume":"21","author":"Buhren","year":"2016","journal-title":"European Journal of Medical Research"},{"issue":"6","key":"10.1002\/14651858.CD010368.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/bja\/78.6.671","article-title":"Hyaluronidase and peribulbar block","volume":"78","author":"Dempsey","year":"1997","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD010368.pub2-BIB0027|cit27","unstructured":"McMaster University (developed by Evidence Prime) GRADEpro GDT 2015"},{"issue":"8","key":"10.1002\/14651858.CD010368.pub2-BIB0028|cit28","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006291.pub3","article-title":"Sub-Tenon's anaesthesia versus topical anaesthesia for cataract surgery","author":"Guay","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD010368.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD010368.pub2-BIB0030|cit30","unstructured":"Higgins JPT Green S editor(s) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD010368.pub2-BIB0031|cit31","unstructured":"Halozyme Therapeutics Inc Hylenex\u00ae recombinant prescribing information, 2016 hylenex.com\/downloads\/approved-uspi-lbl301feb2016.pdf"},{"key":"10.1002\/14651858.CD010368.pub2-BIB0032|cit32","first-page":"159","article-title":"Hyaluronidase induced orbital pseudotumour as complication of retrobulbar anesthesia","volume":"243","author":"Kempeneers","year":"1992","journal-title":"Bulletin de la Societe Belge d'Ophtalmologie"},{"issue":"2","key":"10.1002\/14651858.CD010368.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/eye.1988.26","article-title":"Eyelid and orbital fascial attachments and their clinical significance","volume":"2","author":"Koornneef","year":"1988","journal-title":"Eye"},{"key":"10.1002\/14651858.CD010368.pub2-BIB0034|cit34","first-page":"629","article-title":"The polysaccharide of the vitreous humour","volume":"107","author":"Meyer","year":"1934","journal-title":"Journal of Biochemistry"},{"key":"10.1002\/14651858.CD010368.pub2-BIB0035|cit35","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"9","key":"10.1002\/14651858.CD010368.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/BF03009254","article-title":"Improved peribulbar anaesthesia with alkalinization and hyaluronidase","volume":"40","author":"Roberts","year":"1993","journal-title":"Canadian Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD010368.pub2-BIB0037|cit37","volume-title":"Anaesthesia Management During Cataract Surgery. Evidence Report\/Technology Assessment Number 16 AHRQ Publication No. 00-E015 (Archived)","volume":"1","author":"Schein","year":"2001"},{"key":"10.1002\/14651858.CD010368.pub2-BIB0038|cit38","unstructured":"World Health Organization WHO guidelines on tissue infectivity distribution in transmissible spongiform encephalopathies, 2010 www.who.int\/bloodproducts\/tse\/WHO%20TSE%20Guidelines%20FINAL-22%20JuneupdatedNL.pdf"},{"issue":"2","key":"10.1002\/14651858.CD010368.pub2-BIB0039|cit39","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010368","article-title":"Use of hyaluronidase as an adjunct to local anaesthetic eye blocks","author":"R\u00fcschen","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD010368.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T04:32:34Z","timestamp":1654835554000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD010368.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Anaesthesia Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,2]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd010368.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,2]]}}}