{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:18:07Z","timestamp":1791483487149,"version":"4.3.4"},"update-to":[{"DOI":"10.1002\/14651858.cd010738","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000}}],"reference-count":93,"publisher":"Wiley","issue":"8","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd010738.pub2","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T11:53:39Z","timestamp":1659700419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hydrogel dressings for venous leg ulcers"],"prefix":"10.1002","volume":"2022","author":[{"given":"Cibele TD","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Graduate Program in Physiology, Department of Physiology; Federal University of Paran\u00e1; Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando AL","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Physiology; Federal University of Paran\u00e1; Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme AF","family":"Fregonezi","sequence":"additional","affiliation":[{"name":"PneumoCardioVascular Lab, Onofre Lopes University Hospital, Brazilian Company of Hospital Services (EBSERH) & Department of Physical Therapy; Federal University of Rio Grande do Norte; Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1468-3083.2006.01342.x","article-title":"A novel method of comparing the healing properties of two hydrogels in chronic leg ulcers","volume":"20","author":"De la Brassinne","year":"2006","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"issue":"17-8","key":"10.1002\/14651858.CD010738.pub2-BIB0002|cit2","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1111\/jocn.12652","article-title":"Retraction statement: manuka honey vs. hydrogel \u2013 a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers","volume":"24","year":"2015","journal-title":"Journal of Clinical Nursing"},{"issue":"5","key":"10.1002\/14651858.CD010738.pub2-BIB0003|cit3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1136\/ebm.14.5.148","article-title":"Manuka honey improved wound healing in patients with sloughy venous leg ulcers","volume":"14","author":"Armstrong","year":"2009","journal-title":"Evidence Based Medicine"},{"issue":"6","key":"10.1002\/14651858.CD010738.pub2-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.12968\/jowc.2008.17.6.29583","article-title":"Bacteriological changes in sloughy venous leg ulcers treated with manuka honey or hydrogel: an RCT","volume":"17","author":"Gethin","year":"2008","journal-title":"Journal of Wound Care"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0005|cit5","unstructured":"Gethin G Cowman S Manuka honey versus hydrogel to deslough venous leg ulcers: a randomised controlled trial 17th Conference of the European Wound Management Association; 2007 May 2-4; Glasgow (UK) 2007 29"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0006|cit6","unstructured":"Gethin G Cowman S Manuka honey versus hydrogel to deslough venous leg ulcers: a randomised controlled trial Third Congress of the World Union of Wound Healing Societies Meeting; 2008 Jun 4-8; Toronto (Canada) 2008 4"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0007|cit7","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1365-2702.2008.02558.x","article-title":"Manuka honey vs. hydrogel \u2013 a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous leg ulcers","volume":"18","author":"Gethin","year":"2009","journal-title":"Journal of Clinical Nursing"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0008|cit8","volume-title":"Manuka Honey Versus Hydrogel \u2013 a Prospective, Open Label, Multicentre, Randomised Controlled Trial to Compare Desloughing Efficacy and Healing Outcomes in Venous Ulcers [PhD thesis]","author":"Gethin","year":"2007"},{"issue":"9","key":"10.1002\/14651858.CD010738.pub2-BIB0009|cit9","first-page":"351","article-title":"The phase-oriented wound dressings of ulcus cruris venosum: experience with the use of new hydrogel Opragel","volume":"70","author":"Grotewohl","year":"1994","journal-title":"Zeitschrift fur Allgemeinmedizin"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0010|cit10","first-page":"311","article-title":"A prospective study on wound-healing hydrogel in treating chronic venous ulcer of lower extremities","volume":"22","author":"He","year":"2008","journal-title":"Chinese Journal of Reparative and Reconstructive Surgery"},{"issue":"6","key":"10.1002\/14651858.CD010738.pub2-BIB0011|cit11","first-page":"407","article-title":"New therapy concept in leg ulcer","volume":"24","year":"1994","journal-title":"TW Dermatologie"},{"issue":"2 Suppl","key":"10.1002\/14651858.CD010738.pub2-BIB0012|cit12","first-page":"1","article-title":"Differential therapy of chronic wounds","volume":"48","year":"1997","journal-title":"Hautarzt"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0013|cit13","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.12968\/bjcn.2009.14.Sup1.40104","article-title":"Topical dressings to manage pain in venous leg ulceration","volume":"14","author":"Beldon","year":"2009","journal-title":"British Journal of Community Nursing"},{"issue":"12","key":"10.1002\/14651858.CD010738.pub2-BIB0014|cit14","first-page":"A13","article-title":"Evidence corner: honey on sloughy venous leg ulcers","volume":"20","author":"Bolton","year":"2008","journal-title":"Wounds"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0015|cit15","unstructured":"Farina M Bonifati C Dallavalle E TEAM system in the treatment of venous leg ulcers. A comparative study European Wound Management Association Conference; 1997 Apr 27-9; Milan (Italy) 1997 50 1"},{"issue":"6","key":"10.1002\/14651858.CD010738.pub2-BIB0016|cit16","doi-asserted-by":"publisher","first-page":"264","DOI":"10.12968\/jowc.1995.4.6.264","article-title":"The efficacy of a hydrogel in the treatment of wounds with non-viable tissue","volume":"4","author":"Flanagan","year":"1995","journal-title":"Journal of Wound Care"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0017|cit17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jaad.2007.08.048","article-title":"Treating the chronic wound: a practical approach to the care of nonhealing wounds and wound care dressings","volume":"58","author":"Fonder","year":"2008","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0018|cit18","unstructured":"Gibson B A cost effectiveness comparison of two gels in the treatment of sloughy leg ulcers Symposium on Advanced Wound Care and Medical Research Forum on Wound Repair; 1995 April; San Diego (CA) 1995"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"297","DOI":"10.12968\/jowc.2004.13.7.26639","article-title":"A small study in healing rates and symptom control using a new sheet hydrogel dressing","volume":"7","author":"Hampton","year":"2004","journal-title":"Journal of Wound Care"},{"issue":"21","key":"10.1002\/14651858.CD010738.pub2-BIB0020|cit20","first-page":"10","article-title":"Practical steps to address pain in wound care","volume":"15","author":"Hofman","year":"2006","journal-title":"British Journal of Nursing"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0021|cit21","unstructured":"Hutchinson J Prospective study of clinical infections in wounds dressed with hydrocolloid versus conventional dressings Sixth European Conference on Advances in Wound Management; 1996 Oct 1-4; Amsterdam (Netherlands) 1997 263"},{"issue":"12","key":"10.1002\/14651858.CD010738.pub2-BIB0022|cit22","first-page":"1422","article-title":"Dressing choice unimportant for leg ulcers","volume":"99","author":"JNMA Editorial Office","year":"2007","journal-title":"Journal of the National Medical Association"},{"issue":"7","key":"10.1002\/14651858.CD010738.pub2-BIB0023|cit23","first-page":"24","article-title":"Maggots mixed munching","volume":"13","author":"Jull","year":"2013","journal-title":"Nursing Review"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0024|cit24","unstructured":"Karlsmark T Zillmer R Agren MS Gottrup F Adhesive dressings: effect in healthy and peri-wound skin 12th Conference of the European Wound Management Association; 2002 May 23-25; Granada (Spain) 2002 127"},{"issue":"11","key":"10.1002\/14651858.CD010738.pub2-BIB0025|cit25","doi-asserted-by":"publisher","first-page":"651","DOI":"10.2165\/00115677-200109110-00005","article-title":"Cost and cost effectiveness of venous and pressure ulcer protocols of care","volume":"9","author":"Kerstein","year":"2001","journal-title":"Disease Management and Health Outcomes"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0741-5214(88)90466-1","article-title":"A prospective, randomized trial of Unna's boots versus hydroactive dressing in the treatment of venous stasis ulcers","volume":"7","author":"Kikta","year":"1988","journal-title":"Journal of Vascular Surgery"},{"issue":"1","key":"10.1002\/14651858.CD010738.pub2-BIB0027|cit27","first-page":"14","article-title":"Improved care and reduced costs with advanced wound dressings","volume":"7","author":"Lafferty","year":"2011","journal-title":"Wounds UK"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0028|cit28","unstructured":"Larsen AM Andersen KE Berg BK A comparative study on the effect and function of Comfeel Purilon versus IntraSite gel on leg ulcers European Wound Management Association Conference; 1997, Apr 27-29; Milan (Italy) 1997"},{"issue":"6","key":"10.1002\/14651858.CD010738.pub2-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1024\/0301-1526\/a000230","article-title":"Treatment of chronic wounds","volume":"41","author":"Lawall","year":"2012","journal-title":"Vasa"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0030|cit30","first-page":"116","article-title":"A research roundup of recent papers relevant to wound care","volume":"10","author":"Milne","year":"2014","journal-title":"Wounds UK"},{"issue":"1","key":"10.1002\/14651858.CD010738.pub2-BIB0031|cit31","first-page":"17","article-title":"A comparison of the effectiveness and cost of moist environment dressings treatment as compared to traditional dressings treatment","volume":"23","author":"Perez","year":"2000","journal-title":"Revista de Enfermer\u00eda"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0032|cit32","first-page":"74","article-title":"Cutimed Sorbact gel: a new infection management dressing","volume":"5","author":"Pirie","year":"2009","journal-title":"Wounds UK"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0033|cit33","first-page":"101","volume-title":"Beyond Occlusion: Wound Care Proceedings","author":"Robinson","year":"1988"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0034|cit34","unstructured":"Robinson B A cost-effectiveness comparison of two gels in the treatment of sloughy leg ulcers Fifth European Conference on Advances in Wound Management; 1995 Nov 21-24; Harrogate (UK) 1996 149 50"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0035|cit35","unstructured":"Sironi G Losa S DiLuca G Pezzoni F Patients with venous leg ulcers in vascular treatment with Intrasite gel, Opsite Flexigrid, Allevyn and Flexobande Legere\/Forte: a randomised comparative clinical evaluation \u2013 an interim report 13th Conference of the European Wound Management Association; 2003 May 22-24; Pisa (Italy) 2003"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0036|cit36","unstructured":"Sironi G Losa S DiLuca G Pezzoni F Treatment of venous leg ulcers with Intrasite gel, OpSite Flexigrid, Allevyn hydrocellular dressings and Flexobande (elastic compression bandage) in vascular surgery. A protocol for clinical evaluations 3rd European Conference on Advances in Wound Management; 1993 Oct 19-22; Harrogate (UK) 1994 164"},{"issue":"4","key":"10.1002\/14651858.CD010738.pub2-BIB0037|cit37","first-page":"129","article-title":"Treatment of a bilateral necrotic leg ulcer with Mesitran","volume":"4","author":"Timmons","year":"2008","journal-title":"Wounds UK"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0038|cit38","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0952-3278(94)90135-x","article-title":"Topical treatment of venous leg ulcers with a prostacyclin hydrogel: a double blind trial","volume":"51","author":"Werner-Schlenzka","year":"1994","journal-title":"Prostaglandins Leukotrienes and Essential Fatty Acids"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0039|cit39","first-page":"94","article-title":"Pain management in leg ulcers using ActiFormCool\u2122","volume":"1","author":"Young","year":"2005","journal-title":"Wounds UK"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0040|cit40","unstructured":"Altman MI Mulder GD Multi-centre evaluation of Nu-Gel wound dressing in full-thickness chronic wounds of the lower extremities Third European Conference on Advances in Wound Management; 1993 Oct 19-22; Harrogate (UK) 1993 164 5"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0041|cit41","unstructured":"Gago FM Verdu SJ Garcia-Conzalez RF Guerrero JJ Rueda LJ Gaztelu VV Maceration of the skin surrounding ulcerous lesions. Comparison of seven groups of moist dressings 12th Conference of the European Wound Management Association; 2002 May 23-25; Granada (Spain) 2002 132"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0042|cit42","unstructured":"Hofman D Burgess B Cherry GW Robinson BJ Ryan TJ Management of pressure sores and leg ulcers with Duoderm hydroactive gel Fourth Annual Meeting of the European Tissue Repair Society; 1994 Aug 25-28; Oxford (UK) 1994 198"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0043|cit43","unstructured":"Hofman D Burgess B Management of leg ulcers and pressure sores with Granugel [personal communication] Fax from Smith & Nephew Healthcare 1996"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0044|cit44","doi-asserted-by":"publisher","first-page":"434","DOI":"10.20471\/acc.2018.57.03.05","article-title":"Regeneration of chronic wounds with allogeneic platelet gel versus hydrogel treatment: a prospective study","volume":"57","author":"Semenic","year":"2018","journal-title":"Acta Clinica Croatica"},{"issue":"4","key":"10.1002\/14651858.CD010738.pub2-BIB0045|cit45","first-page":"74","article-title":"Outcome evaluation of two hydrogels","volume":"48","author":"Sparholt","year":"2002","journal-title":"Ostomy\/Wound Management"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0046|cit46","unstructured":"Comparison of cleaning of leg ulcers using pads or wound dressings isrctn.com\/ISRCTN47349949 10.1186\/ISRCTN47349949"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0047|cit47","unstructured":"PluroGel on wounds of mixed etiology clinicaltrials.gov\/ct2\/show\/NCT03275831"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0048|cit48","unstructured":"Effect of therapies combination to healing of venous ulcers, leg pain and self rated health and quality of life of patients in a six month follow-up ensaiosclinicos.gov.br\/rg\/RBR-5d4s4f"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0049|cit49","unstructured":"BMJ Group Royal Pharmaceutical Society of Great Britain British National Formulary (BNF). Wound management products and elasticated garments bnf.nice.org.uk\/wound-management\/"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0050|cit50","first-page":"22","article-title":"Measuring outcomes with complex patients: an audit of the effect of Actiform Cool on painful wounds","volume":"4","author":"Bradbury","year":"2008","journal-title":"Wounds UK"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0051|cit51","first-page":"14","article-title":"The prevalence of leg ulceration: a review of the literature","volume":"3","author":"Briggs","year":"2003","journal-title":"EWMA Journal"},{"issue":"11","key":"10.1002\/14651858.CD010738.pub2-BIB0052|cit52","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001177.pub3","article-title":"Topical agents or dressings for pain in venous leg ulcers","author":"Briggs","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD010738.pub2-BIB0053|cit53","first-page":"989","article-title":"Diagnosis and treatment of venous ulcers","volume":"81","author":"Collins","year":"2010","journal-title":"American Family Physician"},{"issue":"4","key":"10.1002\/14651858.CD010738.pub2-BIB0054|cit54","doi-asserted-by":"publisher","first-page":"326","DOI":"10.7326\/0003-4819-138-4-200302180-00012","article-title":"Managing the patient with venous ulcers","volume":"138","author":"De Araujo","year":"2003","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0055|cit55","unstructured":"Deeks JJ Higgins JP Altman DG Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3\u00a0(updated February\u00a02022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"issue":"1","key":"10.1002\/14651858.CD010738.pub2-BIB0056|cit56","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/hir.12251","article-title":"Development of a search filter to identify reports of controlled clinical trials within CINAHL Plus","volume":"36","author":"Glanville","year":"2019","journal-title":"Health Information and Libraries Journal\u00a0"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0057|cit57","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime) 2021"},{"issue":"7537","key":"10.1002\/14651858.CD010738.pub2-BIB0058|cit58","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1136\/bmj.332.7537.347","article-title":"Venous and arterial leg ulcers \u2013 ABC of wound healing","volume":"332","author":"Grey","year":"2006","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0059|cit59","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.jclinepi.2010.07.017","article-title":"GRADE guidelines: 4. rating the quality of evidence \u2013 study limitations (risk of bias)","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"44","key":"10.1002\/14651858.CD010738.pub2-BIB0060|cit60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-7525-5-44","article-title":"A systematic review on the impact of leg ulceration on patients' quality of life","volume":"5","author":"Herber","year":"2007","journal-title":"Health and Quality of Life Outcomes"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0061|cit61","unstructured":"Higgins JP Altman DG Sterne JA Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s), Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (updated June 2017). Cochrane, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0062|cit62","unstructured":"Higgins JP Thomas J Chandler J Cumpston M Li T Page MJ Cochrane Handbook for Systematic Reviews of Interventions Version 6.3\u00a0(updated February\u00a02022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0063|cit63","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001737.pub3","article-title":"Skin grafting for venous leg ulcers","author":"Jones","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0064|cit64","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jvs.2012.12.055","article-title":"The influence of patient and wound variables on healing of venous leg ulcers in a randomized controlled trial of growth-arrested allogeneic keratinocytes and fibroblasts","volume":"58","author":"Lantis","year":"2013","journal-title":"Journal of Vascular Surgery"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0065|cit65","unstructured":"Lefebvre C Glanville J Briscoe S Featherstone R Littlewood A Marshall C Chapter 4: Searching for and selecting studies. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0066|cit66","unstructured":"Li T Higgins JP Deeks JJ Chapter 5: Collecting data. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3\u00a0(updated February\u00a02022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0067|cit67","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD010738.pub2-BIB0068|cit68","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1590\/S0365-05962003000500002","article-title":"Cicatrization: current concepts and auxiliary resources \u2013 part II","volume":"78","author":"Mandelbaum","year":"2003","journal-title":"Anais Brasileiros de Dermatologia"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0069|cit69","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1067\/mjd.2002.121739","article-title":"Venous leg ulcer: incidence and prevalence in the elderly","volume":"46","author":"Margolis","year":"2002","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0070|cit70","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1067-1927.2004.012207.x","article-title":"The accuracy of venous leg ulcer prognostic models in a wound care system","volume":"12","author":"Margolis","year":"2004","journal-title":"Wound Repair and Regeneration"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0071|cit71","unstructured":"Medical Dictionary medical-dictionary.thefreedictionary.com"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0072|cit72","unstructured":"Glossary www.merriam-webster.com\/medical"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0073|cit73","unstructured":"National Institute for Health and Care Excellence Chronic wounds: advanced wound dressings and antimicrobial dressings Available from www.nice.org.uk\/advice\/esmpb2\/chapter\/Key-points-from-the-evidence"},{"issue":"6","key":"10.1002\/14651858.CD010738.pub2-BIB0074|cit74","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012583.pub2","article-title":"Dressings and topical agents for treating venous leg ulcers","author":"Norman","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD010738.pub2-BIB0075|cit75","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000265.pub2","article-title":"Compression for venous leg ulcers","author":"O'Meara","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD010738.pub2-BIB0076|cit76","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003557.pub3","article-title":"Antibiotics and antiseptics for venous leg ulcers","author":"O'Meara","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0077|cit77","unstructured":"Page MJ Higgins JP Sterne JA Chapter 13: Assessing risk of bias due to missing results in a synthesis. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3\u00a0(updated February\u00a02022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"issue":"7613","key":"10.1002\/14651858.CD010738.pub2-BIB0078|cit78","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1136\/bmj.39248.634977.AE","article-title":"Dressings for venous leg ulcers: systematic review and meta-analysis","volume":"335","author":"Palfreyman","year":"2007","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0079|cit79","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/iwj.13026","article-title":"Epidemiology of venous leg ulcers in primary health care: Incidence and prevalence in a health centre \u2013 a time series study (2010\u20132014)","volume":"16","author":"P\u00e9rez","year":"2019","journal-title":"International Wound Journal"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0080|cit80","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1046\/j.1365-2702.2003.00859.x","article-title":"Leg ulcers: a review of their impact on daily life","volume":"13","author":"Persoon","year":"2004","journal-title":"Journal of Clinical Nursing"},{"issue":"10","key":"10.1002\/14651858.CD010738.pub2-BIB0081|cit81","doi-asserted-by":"publisher","first-page":"306","DOI":"10.25270\/wnds\/2017.10.306310","article-title":"Psychosocial aspects in patients with chronic leg ulcers","volume":"29","author":"Platsidacki","year":"2017","journal-title":"Wounds"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0082|cit82","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1742-481X.2010.00660.x.","article-title":"Cost-of-illness of chronic leg ulcers in Germany","volume":"7","author":"Purwins","year":"2010","journal-title":"International Wound Journal"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0083|cit83","volume-title":"Clinical Practice Guidelines: the Nursing Management of Patients with Venous Leg Ulcers","author":"Royal College of Nursing (RCN)","year":"2006"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0084|cit84","unstructured":"Review Manager Web (RevMan Web) The Cochrane Collaboration 2020"},{"issue":"6","key":"10.1002\/14651858.CD010738.pub2-BIB0085|cit85","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1524-475X.2006.00174.x","article-title":"Guidelines for the treatment of venous ulcers","volume":"14","author":"Robson","year":"2006","journal-title":"Wound Repair and Regeneration"},{"issue":"5","key":"10.1002\/14651858.CD010738.pub2-BIB0086|cit86","doi-asserted-by":"publisher","first-page":"e32","DOI":"10.1016\/j.jvs.2011.09.001","article-title":"2011 ACCF\/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"54","author":"Rooke","year":"2011","journal-title":"Journal of Vascular Surgery"},{"issue":"11","key":"10.1002\/14651858.CD010738.pub2-BIB0087|cit87","doi-asserted-by":"publisher","first-page":"726","DOI":"10.7326\/0003-4819-152-11-201006010-0023","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"152","author":"Schulz","year":"2010","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD010738.pub2-BIB0088|cit88","unstructured":"Sch\u00fcnemann HJ Higgins JP Vist GE Glasziou P Akl EA Skoetz N Chapter 14: Completing 'Summary of findings' tables and grading the certainty of the evidence. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3\u00a0(updated February\u00a02022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0089|cit89","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1067\/mjd.2001.111633","article-title":"Chronic venous insufficiency and venous leg ulceration","volume":"44","author":"Valencia","year":"2001","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"2","key":"10.1002\/14651858.CD010738.pub2-BIB0090|cit90","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ijnurstu.2010.07.001","article-title":"Processes underlying adherence to leg ulcer treatment: a qualitative field study","volume":"48","author":"Hecke","year":"2011","journal-title":"International Journal of Nursing Studies"},{"issue":"5","key":"10.1002\/14651858.CD010738.pub2-BIB0091|cit91","first-page":"218","article-title":"Prevalence, incidence, management, and predictors of venous ulcers in the long-term-care population using the MDS","volume":"13","author":"Wipke-Tevis","year":"2000","journal-title":"Advances in Skin and Wound Care"},{"issue":"3","key":"10.1002\/14651858.CD010738.pub2-BIB0092|cit92","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1177\/1534734606291870","article-title":"A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options","volume":"5","author":"Wollina","year":"2006","journal-title":"International Journal of Lower Extremity Wounds"},{"issue":"9","key":"10.1002\/14651858.CD010738.pub2-BIB0093|cit93","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010738","article-title":"Hydrogel dressings for venous leg ulcers","author":"Ribeiro","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T19:04:17Z","timestamp":1731265457000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD010738.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Wounds Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":93,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd010738.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]}}}