{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:24:04Z","timestamp":1790511844565,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd010995.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000}}],"reference-count":33,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd010995.pub3","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T21:18:45Z","timestamp":1638307125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke"],"prefix":"10.1002","volume":"2021","author":[{"given":"Melinda B","family":"Roaldsen","sequence":"additional","affiliation":[{"name":"Brain and Circulation Research Group, Department of Clinical Medicine; UiT The Arctic University of Norway; Troms\u00f8 Norway"},{"name":"Department of Neurology; University Hospital of North Norway; Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haakon","family":"Lindekleiv","sequence":"additional","affiliation":[{"name":"University Hospital of North Norway; Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellisiv B","family":"Mathiesen","sequence":"additional","affiliation":[{"name":"Brain and Circulation Research Group, Department of Clinical Medicine; UiT The Arctic University of Norway; Troms\u00f8 Norway"},{"name":"Department of Neurology; University Hospital of North Norway; Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"10.1002\/14651858.CD010995.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct","volume":"378","author":"Nogueira","year":"2018","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging","volume":"378","author":"Albers","year":"2018","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/1747493019840938","article-title":"Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection","volume":"14","author":"Ringleb","year":"2019","journal-title":"International Journal of Stroke"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1056\/NEJMoa1813046","article-title":"Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke","volume":"380","author":"Ma","year":"2019","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00234-011-0944-1","article-title":"Perfusion-CT guided intravenous thrombolysis in patients with unknown-onset stroke: a randomized, double-blind, placebo-controlled, pilot feasibility trial","volume":"54","author":"Michel","year":"2012","journal-title":"Neuroradiology"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"1530\u20138","DOI":"10.1161\/STROKEAHA.119.028127","article-title":"Thrombolysis with alteplase at 0.6 mg\/kg for stroke with unknown time of onset: a randomized controlled trial","volume":"51","author":"Koga","year":"2020","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJMoa1804355","article-title":"MRI-guided thrombolysis for stroke with unknown time of onset","volume":"379","author":"Thomalla","year":"2018","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0008|cit8","unstructured":"Wake up symptomatic stroke - benefit of intravenous clot busters or endovascular intervention (WASSABI) clinicaltrials.gov\/ct2\/show\/NCT01455935"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0009|cit9","unstructured":"Mocco J Siddiqui AH Fiorella D Alexander MJ Arthur AS Baxter BW POSITIVE: Perfusion imaging selection of ischemic stroke patients for endovascular therapy Journal of NeuroInterventional Surgery 10.1136\/neurintsurg-2021-017315"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0010|cit10","unstructured":"Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) clinicaltrials.gov\/ct2\/show\/NCT03181360"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0011|cit11","unstructured":"Randomization of endovascular treatment in acute ischemic stroke in the extended time window (RESILIENTExt) clinicaltrials.gov\/ct2\/show\/NCT04256096"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/STROKEAHA.108.528034","article-title":"Thrombolytic therapy for patients who wake-up with stroke","volume":"40","author":"Barreto","year":"2009","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/jnnp.67.4.463","article-title":"Night time versus daytime transient ischaemic attack and ischaemic stroke","volume":"67","author":"Bassetti","year":"1999","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1161\/STROKEAHA.114.005126","article-title":"Reperfusion therapies for wake-up stroke","volume":"45","author":"Buck","year":"2014","journal-title":"Stroke"},{"issue":"9958","key":"10.1002\/14651858.CD010995.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(14)60584-5","article-title":"Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials","volume":"384","author":"Emberson","year":"2014","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0016|cit16","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime)"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0017|cit17","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from training.cochrane.org\/handbook\/archive\/v5.1\/"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0018|cit18","unstructured":"Higgins JP Thomas J Chandler J Cumpston M Li T Page MJ Welch VA Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook"},{"issue":"9859","key":"10.1002\/14651858.CD010995.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD010995.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1111\/ene.14839","article-title":"Thrombolytic therapy for wake-up stroke: a systematic review and meta-analysis","volume":"28","author":"Mac Grory","year":"2021","journal-title":"European Journal of Neurology"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1152\/jappl.1991.70.6.2597","article-title":"Cerebral O2 metabolism and cerebral blood flow in humans during deep and rapid-eye-movement sleep","volume":"70","author":"Madsen","year":"1991","journal-title":"Journal of Applied Physiology"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/STROKEAHA.112.673145","article-title":"An observational study of thrombolysis outcomes in wake-up ischemic stroke patients","volume":"44","author":"Manawadu","year":"2013","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1161\/STROKEAHA.109.576140","article-title":"Off-label thrombolysis is not associated with poor outcome in patients with stroke","volume":"41","author":"Meretoja","year":"2010","journal-title":"Stroke"},{"issue":"9859","key":"10.1002\/14651858.CD010995.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0025|cit25","unstructured":"Review Manager (RevMan) Nordic Cochrane Centre, The Cochrane Collaboration 2020"},{"issue":"6","key":"10.1002\/14651858.CD010995.pub3-BIB0026|cit26","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007574.pub3","article-title":"Endovascular thrombectomy for acute ischaemic stroke","author":"Roaldsen","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.10.003","article-title":"Wake-up stroke within 3 hours of symptom awareness: imaging and clinical features compared to standard recombinant tissue plasminogen activator treated stroke","volume":"22","author":"Roveri","year":"2011","journal-title":"Journal of Stroke and Cerebrovascular Diseases"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000278929","article-title":"Wake-up stroke: clinical and neuroimaging characteristics","volume":"29","author":"Silva","year":"2010","journal-title":"Cerebrovascular Diseases"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1161\/01.CIR.89.6.2892","article-title":"The Early Termination of Clinical Trials","volume":"89","author":"Task Force of the Working Group on Arrhythmias of the European Society of Cardiology","year":"1994","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/S0140-6736(20)32163-2","article-title":"Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data","volume":"396","author":"Thomalla","year":"2020","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD010995.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/S0140-6736(12)60738-7","article-title":"Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis","volume":"379","author":"Wardlaw","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD010995.pub3-BIB0032|cit32","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010995","article-title":"Recanalisation therapies for wake-up stroke","author":"Lindekleiv","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD010995.pub3-BIB0033|cit33","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010995.pub2","article-title":"Recanalisatioan therapies for wake-up stroke","author":"Roaldsen","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:17:32Z","timestamp":1761196652000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD010995.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Stroke Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd010995.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}