{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:38:53Z","timestamp":1793137133905,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd011103","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000}}],"reference-count":65,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd011103.pub2","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T03:20:57Z","timestamp":1510024857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Beta-blockers for preventing aortic dissection in Marfan syndrome"],"prefix":"10.1002","volume":"2017","author":[{"given":"Hyun-Kyoung","family":"Koo","sequence":"first","affiliation":[{"name":"University of British Columbia; 217-2176 Health Sciences Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra AK","family":"Lawrence","sequence":"additional","affiliation":[{"name":"University of Utah; Population Health Sciences; Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya M","family":"Musini","sequence":"additional","affiliation":[{"name":"University of British Columbia; Department of Anesthesiology, Pharmacology and Therapeutics; 2176 Health Science Mall Vancouver BC Canada V6T 1Z3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"issue":"9","key":"10.1002\/14651858.CD011103.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1056\/NEJM199405123301902","article-title":"Progression of aortic dilatation and the benefit of long term beta-adrenergic blockade in Marfan's syndrome","volume":"330","author":"Shores","year":"1994","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/1358863X15569868","article-title":"Distinct effects of losartan and atenolol on vascular stiffness in Marfan syndrome","volume":"20","author":"Bhatt","year":"2015","journal-title":"Vascular Medicine"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/eurheartj\/ehv575","article-title":"Efficacy of losartan vs. atenolol for the prevention of aortic dilation in Marfan syndrome: a randomized clinical trial","volume":"37","author":"Forteza","year":"2016","journal-title":"European Heart Journal"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJMoa1404731","article-title":"Atenolol versus losartan in children and young adults with Marfan's syndrome","volume":"371","author":"Lacro","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ijcard.2014.11.082","article-title":"A randomized, double blind pilot study to assess the effects of losartan vs atenolol on the biophysical properties of the aorta in patients with Marfan and Loeys-Dietz syndromes","volume":"179","author":"Sandor","year":"2015","journal-title":"International Journal of Cardiology"},{"issue":"8","key":"10.1002\/14651858.CD011103.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1365-2362.2012.02668.x","article-title":"Effects of atenolol, perindopril and verapamil on haemodynamic and vascular function in Marfan syndrome - a randomised, double-blind, crossover trial","volume":"42","author":"Williams","year":"2012","journal-title":"European Journal of Clinical Investigation"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ajmg.1320290316","article-title":"International nosology of heritable disorders of connective tissue, Berlin, 1986","volume":"29","author":"Beighton","year":"1988","journal-title":"American Journal of Medical Genetics"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00877747","article-title":"Elastic properties and Windkessel function of the human aorta","volume":"9","author":"Belz","year":"1995","journal-title":"Cardiovascular Drugs and Therapy"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.cjca.2014.02.018","article-title":"Canadian Cardiovascular Society position statement on the management of thoracic aortic disease","volume":"30","author":"Boodhwani","year":"2014","journal-title":"Canadian Journal of Cardiology"},{"issue":"1","key":"10.1002\/14651858.CD011103.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1161\/01.RES.88.1.37","article-title":"Phenotypic alteration of vascular smooth muscle cells precedes elastolysis in a mouse model of Marfan syndrome","volume":"88","author":"Bunton","year":"2001","journal-title":"Circulation Research"},{"issue":"5","key":"10.1002\/14651858.CD011103.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrcardio.2010.31","article-title":"Marfan syndrome. Part 2: treatment and management of patients","volume":"7","author":"Canadas","year":"2010","journal-title":"Nature Reviews. Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1749-6632.2012.06493.x","article-title":"Are we ignoring the dilated thoracic aorta?","volume":"1254","author":"Castellano","year":"2012","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1161\/CIRCULATIONAHA.110.006486","article-title":"Medical therapy of thoracic aortic aneurysms. Are we there yet?","volume":"124","author":"Danyi","year":"2011","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.tcm.2012.07.017","article-title":"Medical therapy of thoracic aortic aneurysms","volume":"22","author":"Danyi","year":"2012","journal-title":"Trends in Cardiovascular Medicine"},{"issue":"4","key":"10.1002\/14651858.CD011103.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","article-title":"Revised diagnostic criteria for the Marfan syndrome","volume":"62","author":"Paepe","year":"1996","journal-title":"American Journal of Medical Genetics"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0016|cit16","unstructured":"Deeks JJ Higgins JPT Altman DG (editors) Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.handbook.cochrane.org"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ppedcard.2012.05.003","article-title":"Marfan syndrome: progress report","volume":"34","author":"Franken","year":"2012","journal-title":"Progress in Pediatric Cardiology"},{"issue":"4","key":"10.1002\/14651858.CD011103.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2459\/JCM.0b013e3283232a45","article-title":"Rationale and design of a trial evaluating the effects of losartan vs. nebivolol vs. the association of both on the progression of aortic root dilation in Marfan syndrome with FBN1 gene mutations","volume":"10","author":"Gambarin","year":"2009","journal-title":"Journal of Cardiovascular Medicine"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1651-2227.2011.02293.x","article-title":"The effect of beta-blocker therapy on progressive aortic dilatation in children and adolescents with Marfan's syndrome: a meta-analysis","volume":"100","author":"Gao","year":"2011","journal-title":"Acta Paediatrica"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijcard.2005.11.116","article-title":"The effect of beta-blocker therapy on clinical outcome in patients with Marfan's syndrome: a meta-analysis","volume":"114","author":"Gersony","year":"2007","journal-title":"International Journal of Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9149(98)00315-4","article-title":"Changes in aortic distensibility and pulse wave velocity assessed with magnetic resonance imaging following beta-blocker therapy in the Marfan syndrome","volume":"82","author":"Groenink","year":"1998","journal-title":"American Journal of Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0022|cit22","first-page":"123","article-title":"A prospectus on the prevention of aortic rupture in the Marfan syndrome with data on survivorship without treatment","volume":"129","author":"Halpern","year":"1971","journal-title":"Johns Hopkins Medical Journal"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0024|cit24","unstructured":"Higgins JPT Altman DG Sterne JAC (editors) Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"1","key":"10.1002\/14651858.CD011103.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0735-1097(10)80218-9","article-title":"The Marfan syndrome: abnormal aortic elastic properties","volume":"181","author":"Hirata","year":"1991","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIR.0b013e3181d47d48","article-title":"2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine","volume":"121","author":"Hiratzka","year":"2010","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(05)67789-6","article-title":"Marfan's syndrome","volume":"366","author":"Judge","year":"2005","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1161\/CIRCULATIONAHA.107.693523","article-title":"Medical management of Marfan syndrome","volume":"117","author":"Keane","year":"2008","journal-title":"Circulation"},{"issue":"2","key":"10.1002\/14651858.CD011103.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2298\/VSP1202195K","article-title":"Should we prescribe \"vasodilating\" beta-blockers in Marfan syndrome to prevent aortic aneurysm and dissection?","volume":"69","author":"Koracevic","year":"2012","journal-title":"Vojnosanitetski Pregled. Military-Medical and Pharmaceutical Review"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.amjcard.2006.08.048","article-title":"Effect of beta blockade on ascending aortic dilatation in children with the Marfan syndrome","volume":"99","author":"Ladouceur","year":"2007","journal-title":"American Journal of Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0031|cit31","unstructured":"Lefebvre C Manheimer E Glanville J Chapter 6: Searching for studies. In Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Review of Interventions Version 5.1.0. (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/hrt.75.4.389","article-title":"Aortic root complications in Marfan's syndrome: identification of a lower risk group","volume":"75","author":"Legget","year":"1996","journal-title":"Heart"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ccl.2010.01.002","article-title":"Does medical therapy for thoracic aortic aneurysms really work? Are beta-blockers truly indicated?","volume":"28","author":"Liao","year":"2010","journal-title":"Cardiology Clinics"},{"issue":"7","key":"10.1002\/14651858.CD011103.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"Journal of Medical Genetics"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0035|cit35","unstructured":"Loke YK Price D Herxheimber A Chapter 14: Adverse effects. In: Higgins JPT, Green S (editors), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-9013-6_1","article-title":"Historical introduction. The Marfan syndrome: from clinical delineation to mutational characterization, a semiautobiographic account","volume-title":"Marfan Syndrome: a Primer for Clinicans and Scientists","author":"McKusick","year":"2004"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/eurheartj\/ehv151","article-title":"Marfan Sartan: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Milleron","year":"2015","journal-title":"European Heart Journal"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijcard.2010.12.070","article-title":"The Ghent Marfan Trial - a randomized, double-blind placebo controlled trial with losartan in Marfan patients treated with \u03b2-blockers","volume":"157","author":"Moberg","year":"2012","journal-title":"International Journal of Cardiology"},{"issue":"7","key":"10.1002\/14651858.CD011103.pub2-BIB0039|cit39","doi-asserted-by":"publisher","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Medicine"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-6215-14-408","article-title":"A prospective, randomized, placebo-controlled, double-blind, multicenter study of the effects of irbesartan on aortic dilatation in Marfan syndrome (AIMS trial): study protocol","volume":"14","author":"Mullen","year":"2013","journal-title":"Trials"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJM197204132861502","article-title":"Life expectancy and causes of death in the Marfan syndrome","volume":"286","author":"Murdoch","year":"1972","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jpeds.2014.07.008","article-title":"\u03b2-Blockers and angiotensin converting enzyme inhibitors: comparison of effects on aortic growth in pediatric patients with Marfan syndrome","volume":"165","author":"Phomakay","year":"2014","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ahj.2015.01.011","article-title":"Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: a report from the Marfan Treatment Trialists\u2019 Collaboration","volume":"169","author":"Pitcher","year":"2015","journal-title":"American Heart Journal"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.med.51.1.481","article-title":"The Marfan syndrome","volume":"51","author":"Pyeritz","year":"2000","journal-title":"Annual Review of Medicine"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1056\/NEJMe0804008","article-title":"A small molecule for a large disease","volume":"358","author":"Pyeritz","year":"2008","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD011103.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/hrt.2008.160515","article-title":"Marfan syndrome: 30 years of research equals 30 years of additional life expectancy","volume":"95","author":"Pyeritz","year":"2009","journal-title":"Heart (British Cardiac Society)"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/gim.2011.48","article-title":"Evaluation of the adolescent or adult with some features of Marfan syndrome","volume":"14","author":"Pyeritz","year":"2012","journal-title":"Genetics in Medicine"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jpeds.2014.08.002","article-title":"What is the optimal medical therapy for Marfan syndrome?","volume":"165","author":"Pyeritz","year":"2014","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0049|cit49","unstructured":"Nordic Cochrane Centre, The Cochrane Collaboration Review Manager 5 (RevMan 5) 2014"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0002-8703(99)70362-5","article-title":"Effect of long-term \u03b2-blockade on aortic root compliance in patients with Marfan syndrome","volume":"137","author":"Rios","year":"1999","journal-title":"American Heart Journal"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0002-9149(99)00101-0","article-title":"Phenotypic features and impact of beta blocker or calcium antagonist therapy on aortic lumen size in the Marfan syndrome","volume":"83","author":"Rossi-Foulkes","year":"1999","journal-title":"American Journal of Cardiology"},{"issue":"9","key":"10.1002\/14651858.CD011103.pub2-BIB0052|cit52","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009536.pub2","article-title":"Medical treatment for small abdominal aortic aneurysms","author":"Rughani","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0002-9149(94)90762-5","article-title":"Effect of beta-adrenergic blockade on aortic root rate of dilation in the Marfan syndrome","volume":"74","author":"Salim","year":"1994","journal-title":"American Journal of Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpeds.2006.09.003","article-title":"Beta-blocker therapy does not alter the rate of aortic root dilation in pediatric patients with Marfan syndrome","volume":"150","author":"Selamet Tierney","year":"2007","journal-title":"Journal of Pediatrics"},{"issue":"2","key":"10.1002\/14651858.CD011103.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0002-9149(00)80066-1","article-title":"Life expectancy in the Marfan syndrome","volume":"75","author":"Silverman","year":"1995","journal-title":"American Journal of Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cjca.2015.11.003","article-title":"Recent clinical drug trials evidence in Marfan syndrome and clinical implications","volume":"32","author":"Singh","year":"2016","journal-title":"Canadian Journal of Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00007611-199303000-00012","article-title":"Cardiovascular anomalies in Marfan's syndrome: the role of echocardiography and b-blockers","volume":"86","author":"Tahernia","year":"1993","journal-title":"Southern Medical Journal"},{"issue":"1","key":"10.1002\/14651858.CD011103.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpeds.2006.09.003","article-title":"Beta-blocker therapy does not alter the rate of aortic root dilation in pediatric patients with Marfan syndrome","volume":"150","author":"Tierney","year":"2007","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/sj.jhh.1000581","article-title":"Assessment of the acute arterial effects of converting enzyme inhibition in essential hypertension: a double-blind comparative and crossover study","volume":"12","author":"Topouchian","year":"1998","journal-title":"Journal of Human Hypertension"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/0974-2069.43885","article-title":"Role of beta-blockers in Marfan's syndrome and bicuspid aortic valve: a time for re-appraisal","volume":"1","author":"Vaidyanathan","year":"2008","journal-title":"Annals of Pediatric Cardiology"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-4419-9013-6_5","article-title":"Cardiovascular aspects of the Marfan syndrome: a systematic review","volume-title":"Marfan Syndrome: a Primer for Clinicans and Scientists","author":"Kodolitsch","year":"2004"},{"issue":"6","key":"10.1002\/14651858.CD011103.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/hrt.2006.098798","article-title":"Marfan syndrome: an update of genetics, medical and surgical management","volume":"93","author":"Kodolitsch","year":"2007","journal-title":"Heart (British Cardiac Society)"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0063|cit63","unstructured":"Wright JM Connolly HM Management of Marfan syndrome and related disorders In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0064|cit64","unstructured":"Wright JM Connolly HM Genetics, clinical features, and diagnosis of Marfan syndrome and related disorders In: UpToDate, Post TW (Ed), UpToDate, Waltham MA (Accessed June 2017)"},{"key":"10.1002\/14651858.CD011103.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.amjcard.2005.01.032","article-title":"Usefulness of enalapril versus propranolol or atenolol for prevention of aortic dilation in patients with the Marfan syndrome","volume":"95","author":"Yetman","year":"2005","journal-title":"American Journal of Cardiology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD011103.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T22:08:29Z","timestamp":1750975709000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD011103.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Heart Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":65,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd011103.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,7]]}}}