{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:50:34Z","timestamp":1767135034034,"version":"build-2238731810"},"update-to":[{"DOI":"10.1002\/14651858.cd011130","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000}}],"reference-count":47,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd011130.pub2","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T20:58:23Z","timestamp":1455569903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Folate supplementation in people with sickle cell disease"],"prefix":"10.1002","author":[{"given":"Ruchita","family":"Dixit","sequence":"first","affiliation":[{"name":"Melaka-Manipal Medical College; Department of Community Medicine; Jalan Batu Hampar Bukit Baru Melaka Malaysia 75150"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sowmya","family":"Nettem","sequence":"additional","affiliation":[{"name":"Faculty Of Dentistry, Melaka-Manipal Medical College; Department of Periodontics; Jalan Batu Hampar, Bukit Baru Melaka Malaysia 75150"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simerjit S","family":"Madan","sequence":"additional","affiliation":[{"name":"Melaka-Manipal Medical College; Department of Orthopaedics; Jalan Batu Hampar Bukit Baru Melaka Melaka Malaysia 75150"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Htoo Htoo Kyaw","family":"Soe","sequence":"additional","affiliation":[{"name":"Melaka-Manipal Medical College; Department of Community Medicine; Jalan Batu Hampar Bukit Baru Melaka Malaysia 75150"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adinegara BL","family":"Abas","sequence":"additional","affiliation":[{"name":"Melaka-Manipal Medical College; Department of Community Medicine; Jalan Batu Hampar Bukit Baru Melaka Malaysia 75150"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah D","family":"Vance","sequence":"additional","affiliation":[{"name":"Vanderbilt University; School of Medicine; 2200 Children\u0092s Way 11232A DOT Nashville Tennessee USA 37232"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J","family":"Stover","sequence":"additional","affiliation":[{"name":"Cornell University; Department of Nutritional Sciences; 127 Savage Hall Ithaca New York USA 14850"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"issue":"4","key":"10.1002\/14651858.CD011130.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2141.1983.tb02138.x","article-title":"A trial of folate supplementation in children with homozygous sickle cell disease","volume":"54","author":"Rabb","year":"1983","journal-title":"British Journal of Haematology"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0002|cit2","first-page":"Abstract no: 40","article-title":"Ready-to-use supplementary food supplements improve endothelial function, hemoglobin and growth in Tanzanian children with sickle cell anaemia: the vascular function intervention study (V-FIT), a random order crossover trial [abstract]","volume":"89","author":"Cox","year":"2014","journal-title":"Proceedings of the 56th ASH Annual Meeting and Exposition; 2014 Dec 6-9; San Francisco, California"},{"issue":"1 Suppl Meeting","key":"10.1002\/14651858.CD011130.pub2-BIB0003|cit3","article-title":"Amino acids in Tanzanian children with sickle cell disease: Baseline results of the vascular function intervention trial (VFIT) [abstract]","volume":"29","author":"Marealle","year":"2015","journal-title":"FASEB Journal"},{"issue":"2","key":"10.1002\/14651858.CD011130.pub2-BIB0004|cit4","first-page":"55","article-title":"Sickle cell anaemia: report of a therapeutic trial","volume":"15","author":"Hendrickse","year":"1966","journal-title":"West African Medical Journal"},{"issue":"1","key":"10.1002\/14651858.CD011130.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-0609.1975.tb00295.x","article-title":"Folic acid deficiency in sickle cell anemia","volume":"14","author":"Liu","year":"1975","journal-title":"Scandanavian Journal of Haematology"},{"issue":"3","key":"10.1002\/14651858.CD011130.pub2-BIB0006|cit6","first-page":"266","article-title":"The effect of folic acid supplementation in beta-thalassemia major: a randomized placebo-controlled clinical trial","volume":"9","author":"Mojtahedzadeh","year":"2006","journal-title":"Archives of Iranian Medicine"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0007|cit7","unstructured":"Kim-Shapiro DB Dixon N Study of Beet Juice for Patients With Sickle Cell Anemia (NCT02162225) https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02162225"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"A91","DOI":"10.1136\/archdischild-2012-301885.219","article-title":"Folic acid supplementation in children with sickle cell disease","volume":"97","author":"Al-Yassin","year":"2012","journal-title":"Archives of Disease in Childhood"},{"issue":"1","key":"10.1002\/14651858.CD011130.pub2-BIB0009|cit9","first-page":"7","article-title":"Current therapy of sickle cell disease","volume":"91","author":"Aliyu","year":"2006","journal-title":"Haematologica"},{"issue":"6","key":"10.1002\/14651858.CD011130.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1301\/nr.2004.jun.S14-S20","article-title":"Folate and vitamin B12 recommended intakes and status in the United States","volume":"62","author":"Bailey","year":"2004","journal-title":"Nutrition Reviews"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/9781119946045.ch21","article-title":"Folate","volume-title":"Present Knowledge in Nutrition","author":"Bailey","year":"2012"},{"issue":"1","key":"10.1002\/14651858.CD011130.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/ije\/dyq028","article-title":"Folic acid to reduce neonatal mortality from neural tube disorders","volume":"39","author":"Blencowe","year":"2010","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0013|cit13","first-page":"470","article-title":"Folic Acid","volume-title":"Modern Nutrition in Health and Disease","author":"Carmel","year":"2005"},{"issue":"7135","key":"10.1002\/14651858.CD011130.pub2-BIB0014|cit14","first-page":"894-8","article-title":"Lowering blood homocysteine with folic acid based supplements: meta analysis of randomized trials","volume":"316","author":"Homocysteine Lowering Trialists' Collaboration","year":"1998","journal-title":"BMJ"},{"issue":"18","key":"10.1002\/14651858.CD011130.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1001\/archinternmed.2010.348","article-title":"Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals","volume":"170","author":"Clarke","year":"2010","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0016|cit16","unstructured":"Deeks J Higgins J Altman D Chapter 9: Analysing data and undertaking meta-analysis. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org"},{"issue":"22","key":"10.1002\/14651858.CD011130.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"2204-7","DOI":"10.1056\/NEJMoa022639","article-title":"Pernicious anemia with neuropsychiatric dysfunction in a patient with sickle cell anemia treated with folate supplementation","volume":"348","author":"Dhar","year":"2003","journal-title":"New England Journal of Medicine"},{"issue":"9557","key":"10.1002\/14651858.CD011130.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0140-6736(07)60109-3","article-title":"Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial","volume":"369","author":"Durga","year":"2007","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD011130.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0022-3476(95)70154-0","article-title":"Discontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II","volume":"127","author":"Falletta","year":"1995","journal-title":"Journal of Pediatrics"},{"issue":"1","key":"10.1002\/14651858.CD011130.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/inthealth\/iht022","article-title":"Current sickle cell disease management practices in Nigeria","volume":"6","author":"Galadanci","year":"2014 Mar","journal-title":"International health"},{"issue":"2","key":"10.1002\/14651858.CD011130.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"666S","DOI":"10.3945\/ajcn.110.009613","article-title":"Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies","volume":"94","author":"Green","year":"2011 Aug","journal-title":"American Journal of Clinical Nutrition"},{"issue":"6 Suppl 4","key":"10.1002\/14651858.CD011130.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.amepre.2011.09.013","article-title":"Sickle cell disease in Africa: a neglected cause of early childhood mortality","volume":"41","author":"Grosse","year":"2011","journal-title":"American Journal of Preventive Medicine"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0023|cit23","unstructured":"Higgins JPT Altman DG Sterne JAC Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March2011] The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0024|cit24","unstructured":"Higgins JPT Deeks JJ Altman DG (editors) Chapter 16: Special topics in statistics. In: Higgins JPT, Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011) The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org"},{"issue":"13","key":"10.1002\/14651858.CD011130.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jama.2015.2274","article-title":"Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial","volume":"313","author":"Huo","year":"2015","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"326-8","DOI":"10.1038\/180326a0","article-title":"Gene mutations in human haemoglobin: the chemical difference between normal and sickle haemoglobin","volume":"180","author":"Ingram","year":"1957","journal-title":"Nature"},{"issue":"10","key":"10.1002\/14651858.CD011130.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"1387-9","DOI":"10.1136\/gut.2006.095463","article-title":"Folate: a magic bullet or a double edged sword for colorectal cancer prevention?","volume":"55","author":"Kim","year":"2006","journal-title":"Gut"},{"issue":"3","key":"10.1002\/14651858.CD011130.pub2-BIB0028|cit28","first-page":"639","article-title":"Sickle Cell Disease","volume":"43","author":"Peter","year":"1996","journal-title":"Pediatric Hematology"},{"issue":"6","key":"10.1002\/14651858.CD011130.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/STROKEAHA.109.573410","article-title":"Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: a meta-analysis","volume":"41","author":"Lee","year":"2010","journal-title":"Stroke"},{"issue":"4","key":"10.1002\/14651858.CD011130.pub2-BIB0030|cit30","first-page":"238-43","article-title":"Pharmacological management of sickle cell disease","volume":"33","author":"Ndefo","year":"2008","journal-title":"Pharmacy and Therapeutics"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"543-8","DOI":"10.1126\/science.110.2865.543","article-title":"Sickle cell anemia: a molecular disease","volume":"110","author":"Pauling","year":"1949","journal-title":"Science"},{"issue":"9757","key":"10.1002\/14651858.CD011130.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0033|cit33","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"9505","key":"10.1002\/14651858.CD011130.pub2-BIB0034|cit34","first-page":"133","article-title":"Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial","volume":"367","author":"Sazawal","year":"2006","journal-title":"Present Knowledge in Nutrition"},{"issue":"10","key":"10.1002\/14651858.CD011130.pub2-BIB0035|cit35","first-page":"364","article-title":"Sickle cell disease; a general overview","volume":"62","author":"Schnog","year":"2004","journal-title":"Netherlands Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD011130.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"286-91","DOI":"10.1056\/NEJM199502023320502","article-title":"Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis","volume":"332","author":"Selhub","year":"1995","journal-title":"New England Journal of Medicine"},{"issue":"9079","key":"10.1002\/14651858.CD011130.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"725-30","DOI":"10.1016\/S0140-6736(97)07330-3","article-title":"Sickle-cell disease","volume":"350","author":"Serjeant","year":"1997","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0038|cit38","volume-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline","author":"Standing Committee on the Scientific Evaluation of Dietary Reference Intakes","year":"1998"},{"issue":"6","key":"10.1002\/14651858.CD011130.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/ajcn\/82.6.1320","article-title":"Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease","volume":"82","author":"Stott","year":"2005","journal-title":"American Journal of Clinical Nutrition"},{"issue":"9442","key":"10.1002\/14651858.CD011130.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1343-60","DOI":"10.1016\/S0140-6736(04)17192-4","article-title":"Sickle cell disease","volume":"364","author":"Stuart","year":"2004","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD011130.pub2-BIB0041|cit41","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003390","article-title":"Folate for depressive disorders","author":"Taylor","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD011130.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/jn\/136.1.189","article-title":"Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women","volume":"136","author":"Troen","year":"2006","journal-title":"Journal of Nutrition"},{"issue":"9871","key":"10.1002\/14651858.CD011130.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0140-6736(12)62001-7","article-title":"Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals","volume":"381","author":"Vollset","year":"2013","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD011130.pub2-BIB0044|cit44","unstructured":"Wolff T Witkop CT Miller T Syed SB Folic Acid Supplementation for the Prevention of Neural Tube Defects: An Update of the Evidence for the U.S. Preventive Services Task Force http:\/\/www.uspreventiveservicestaskforce.org\/Page\/Document\/RecommendationStatementFinal\/folic-acid-to-prevent-neural-tube-defects-preventive-medication"},{"issue":"26","key":"10.1002\/14651858.CD011130.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1182\/blood-2014-08-435768","article-title":"Update on the use of hydroxyurea therapy in sickle cell disease","volume":"124","author":"Wong","year":"2014","journal-title":"Blood"},{"issue":"1","key":"10.1002\/14651858.CD011130.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3945\/ajcn.111.013011","article-title":"Biomarkers of folate status in NHANES: a roundtable summary","volume":"94","author":"Yetley","year":"2011","journal-title":"American Journal of Clinical Nutrition"},{"issue":"1","key":"10.1002\/14651858.CD011130.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3945\/ajcn.2010.30127","article-title":"Contributions of enriched cereal-grain products, ready-to-eat cereals, and supplements to folic acid and vitamin B-12 usual intake and folate and vitamin B-12 status in US children:National Health and Nutrition Examination Survey (NHANES), 2003-2006","volume":"93","author":"Yeung","year":"2011","journal-title":"American Journal of Clinical Nutrition"}],"updated-by":[{"DOI":"10.1002\/14651858.cd011130.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD011130.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T18:52:47Z","timestamp":1628535167000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD011130.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Cystic Fibrosis and Genetic Disorders Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,16]]},"references-count":47,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd011130.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,16]]}}}