{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:08:12Z","timestamp":1788998892130,"version":"build-2803163510"},"update-to":[{"DOI":"10.1002\/14651858.cd011167","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000}}],"reference-count":49,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd011167.pub2","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T15:10:55Z","timestamp":1519225855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antibiotics for treating gonorrhoea in pregnancy"],"prefix":"10.1002","volume":"2018","author":[{"given":"Gabriella","family":"Comuni\u00e1n-Carrasco","sequence":"first","affiliation":[{"name":"Universidad de Carabobo; Departamento de Obstetricia y Ginecolog\u00eda; Urbanizaci\u00f3n Fundaci\u00f3n Mendoza calle 19 5ta etapa N\u00b0 22-40 Valencia Estado Carabobo Venezuela 2001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiomar E","family":"Pe\u00f1a-Mart\u00ed","sequence":"additional","affiliation":[{"name":"Universidad de Carabobo; Departamento de Obstetricia y Ginecolog\u00eda; Urbanizaci\u00f3n Fundaci\u00f3n Mendoza calle 19 5ta etapa N\u00b0 22-40 Valencia Estado Carabobo Venezuela 2001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo J","family":"Mart\u00ed-Carvajal","sequence":"additional","affiliation":[{"name":"Iberoamerican Cochrane Network; Valencia Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"10.1002\/14651858.CD011167.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0002-9378(91)90934-J","article-title":"Treatment of gonorrhea in pregnancy","volume":"164","author":"Cavenee","year":"1991","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD011167.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0020-7292(93)90294-7","article-title":"Treatment of gonorrhea in pregnancy","volume":"43","author":"Cavenee","year":"1993","journal-title":"International Journal of Gynecology & Obstetrics"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0003|cit3","first-page":"33","article-title":"Treatment of gonorrhea in pregnancy","volume":"81","author":"Cavenee","year":"1993","journal-title":"Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0004|cit4","first-page":"409","article-title":"Evaluation of the current CDC recommended treatment guidelines for gonorrhea in pregnancy","volume":"174","author":"Ramus","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD011167.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1067\/mob.2001.117662","article-title":"A randomized trial that compared oral cefixime and intramuscular ceftriaxone for the treatment of gonorrhea in pregnancy","volume":"185","author":"Ramus","year":"2001","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD011167.pub2-BIB0006|cit6","first-page":"86","article-title":"Effect observation of treating pregnancy gonorrhea with combination of western medicine and traditional Chinese medicine","volume":"3","author":"Shi","year":"1997","journal-title":"Chinese Journal of Prevention and Control of STD and AIDS"},{"issue":"7003","key":"10.1002\/14651858.CD011167.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/bmj.311.7003.485","article-title":"Absence of evidence is not evidence of absence","volume":"311","author":"Altman","year":"1995","journal-title":"BMJ (Clinical research ed.)"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0008|cit8","first-page":"294-307","article-title":"Cephalosporins","volume-title":"Principles and Practice of Infectious Diseases","author":"Andes","year":"2005"},{"issue":"4","key":"10.1002\/14651858.CD011167.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11019-017-9773-2","article-title":"What's in a gold standard? In defence of randomised controlled trials","volume":"20","author":"Backmann","year":"2017","journal-title":"Medicine, Health Care, and Philosophy"},{"issue":"3","key":"10.1002\/14651858.CD011167.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/0962280207080639","article-title":"On improving research methodology in clinical trials","volume":"17","author":"Berger","year":"2008","journal-title":"Statistical Methods in Medical Research"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0011|cit11","volume-title":"Goodman and Gilman's Pharmacological Basis of Therapeutics","author":"Brunton","year":"2018"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0012|cit12","unstructured":"Centers for Disease Control and Prevention Gonococcal Infections Sexually Transmitted Diseases Treatment Guidelines. www.cdc.gov\/std\/tg2015\/gonorrhea.htm"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0013|cit13","unstructured":"Centers for Disease Control and Prevention Gonorrhea Sexually Transmitted Diseases Surveillance. www.cdc.gov\/std\/stats16\/Gonorrhea.htm"},{"issue":"3","key":"10.1002\/14651858.CD011167.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7326\/0003-4819-158-3-201302050-00583","article-title":"SPIRIT 2013 statement: defining standard protocol items for clinical trials","volume":"158","author":"Chan","year":"2013","journal-title":"Annals of Internal Medicine"},{"issue":"1","key":"10.1002\/14651858.CD011167.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.7326\/0003-4819-155-1-201107050-00006","article-title":"Single-center trials show larger treatment effects than multicenter trials: evidence from a meta-epidemiologic study","volume":"155","author":"Dechartres","year":"2011","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0016|cit16","first-page":"1019","article-title":"Tetracyclines, macrolides, clindamycin, chloramphenicol, streptogramins & oxazolidinones","volume-title":"Basic & Clinical Pharmacology","author":"Deck","year":"2009"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0017|cit17","first-page":"790","article-title":"Beta-lactam & other cell wall- & membrane-active antibiotics","volume-title":"Basic & Clinical Pharmacology","author":"Deck","year":"2012"},{"issue":"15","key":"10.1002\/14651858.CD011167.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1001\/jama.2014.11100","article-title":"The PCORI perspective on patient-centered outcomes research","volume":"312","author":"Frank","year":"2014","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0019|cit19","unstructured":"McMaster University (developed by Evidence Prime) GRADEpro GDT 2015"},{"issue":"2","key":"10.1002\/14651858.CD011167.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccc.2007.12.011","article-title":"Antibiotic adverse reactions and drug interactions","volume":"24","author":"Granowitz","year":"2008","journal-title":"Critical Care Clinics"},{"issue":"7650","key":"10.1002\/14651858.CD011167.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"7651","key":"10.1002\/14651858.CD011167.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/bmj.39490.551019.BE","article-title":"What is \"quality of evidence\" and why is it important to clinicians?","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0023|cit23","first-page":"391","article-title":"The impact of infection during pregnancy on the mother and baby","volume-title":"Fetal and Neonatal Pathology","author":"Heather","year":"2007"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0024|cit24","unstructured":"Higgins JPT Deeks JJ Altman DG editor(s) Chapter 16: Special topics in statistics. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0025|cit25","unstructured":"Higgins JPT Green S editor(s) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"9","key":"10.1002\/14651858.CD011167.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.15698\/mic2016.09.524","article-title":"Gonorrhea - an evolving disease of the new millennium","volume":"3","author":"Hill","year":"2016","journal-title":"Microbial Cell"},{"issue":"10","key":"10.1002\/14651858.CD011167.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.7326\/0003-4819-141-10-200411160-00009","article-title":"Better reporting of harms in randomized trials: an extension of the CONSORT statement","volume":"141","author":"Ioannidis","year":"2004","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0028|cit28","first-page":"79","article-title":"Biology of neisseria gonorrhoeae and the clinical picture of infections","volume-title":"Sexually Transmitted Infections and Sexually Transmitted Diseases","author":"Ison","year":"2001"},{"issue":"3","key":"10.1002\/14651858.CD011167.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.15585\/mmwr.mm6603a3","article-title":"Prevalence of pelvic inflammatory disease in sexually experienced women of reproductive age - United States, 2013-2014","volume":"66","author":"Kreisel","year":"2017","journal-title":"Morbidity and Mortality Weekly Report"},{"issue":"3","key":"10.1002\/14651858.CD011167.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1517\/14740338.2012.643866","article-title":"Adverse reactions to betalactam antimicrobials","volume":"11","author":"Lagace-Wiens","year":"2012","journal-title":"Expert Opinion on Drug Safety"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/B978-1-4557-4801-3.00214-9","article-title":"Neisseria gonorrhoeae (Gonorrhea)","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"Marrazzo","year":"2015"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0032|cit32","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1136\/sti.2002.004077","article-title":"Sexually transmitted infections in pregnancy: prevalence, impact on pregnancy outcomes, and approach to treatment in developing countries","volume":"81","author":"Mullick","year":"2005","journal-title":"Sexually Transmitted Infections"},{"issue":"10","key":"10.1002\/14651858.CD011167.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"795","DOI":"10.7326\/0003-4819-140-10-200405180-00009","article-title":"Clarifying adverse drug events: a clinician\u2019s guide to terminology, documentation, and reporting","volume":"140","author":"Nebeker","year":"2004","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jclinepi.2017.02.010","article-title":"Simple randomization did not protect against bias in smaller trials","volume":"84","author":"Nguyen","year":"2017","journal-title":"Journal of Clinical Epidemiology"},{"issue":"12","key":"10.1002\/14651858.CD011167.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/OLQ.0000000000000515","article-title":"Gonorrhea control, United States, 1972-2015, a narrative review","volume":"43","author":"Peterman","year":"2016","journal-title":"Sexually Transmitted Diseases"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0036|cit36","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager 5 (RevMan 5) 2014"},{"issue":"3","key":"10.1002\/14651858.CD011167.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/OLQ.0b013e318286bb53","article-title":"Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008","volume":"40","author":"Satterwhite","year":"2013","journal-title":"Sexually Transmitted Diseases"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0038|cit38","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G Oxman A editor(s) Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach (updated October 2013). GRADE Working Group, 2013 Available from gdt.guidelinedevelopment.org\/app\/handbook\/handbook.html"},{"issue":"2","key":"10.1002\/14651858.CD011167.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1586\/eri.10.171","article-title":"Emerging resistance in Neisseria meningitidis and Neisseria gonorrhoeae","volume":"9","author":"Stefanelli","year":"2011","journal-title":"Expert Review of Anti-Infective Therapy"},{"issue":"4","key":"10.1002\/14651858.CD011167.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.mcna.2010.04.006","article-title":"The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams","volume":"94","author":"Torres","year":"2010","journal-title":"Medical Clinics of North America"},{"issue":"11","key":"10.1002\/14651858.CD011167.pub2-BIB0041|cit41","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.MR000030.pub2","article-title":"Consolidated standards of reporting trials (CONSORT) and the completeness of reporting of randomised controlled trials (RCTs) published in medical journals","author":"Turner","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD011167.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jclinepi.2013.05.016","article-title":"Single-center trials tend to provide larger treatment effects than multicenter trials: a systematic review","volume":"66","author":"Unverzagt","year":"2013","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0043|cit43","unstructured":"World Health Organization (WHO) Sexually transmitted and other reproductive tract infections hetv.org\/resources\/reproductive-health\/rtis_gep\/rtis_gep.pdf (accessed June 2014)"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0044|cit44","unstructured":"World Health Organization (WHO) Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoea whqlibdoc.who.int\/publications\/2012\/9789241503501_eng.pdf (accessed June 2014)"},{"key":"10.1002\/14651858.CD011167.pub2-BIB0045|cit45","unstructured":"World Health Organization (WHO) WHO guidelines for the treatment of Neisseria gonorrhoeae www.who.int\/reproductivehealth\/publications\/rtis\/gonorrhoea-treatment-guidelines\/en\/"},{"issue":"4","key":"10.1002\/14651858.CD011167.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1053\/j.spid.2005.06.006","article-title":"Gonococcal infections in neonates and young children","volume":"16","author":"Woods","year":"2005","journal-title":"Seminars in Pediatric Infectious Diseases"},{"issue":"RR12","key":"10.1002\/14651858.CD011167.pub2-BIB0047|cit47","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"Workowski","year":"2010","journal-title":"Mortality and Morbidity Weekly Report"},{"issue":"2","key":"10.1002\/14651858.CD011167.pub2-BIB0048|cit48","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000098","article-title":"Antibiotics for gonorrhoea in pregnancy","author":"Brocklehurst","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD011167.pub2-BIB0049|cit49","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011167","article-title":"Antibiotics for gonorrhoea in pregnancy","author":"Comuni\u00e1n-Carrasco","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD011167.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T13:32:51Z","timestamp":1631280771000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD011167.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Pregnancy and Childbirth Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd011167.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]}}}