{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:43:26Z","timestamp":1790772206201,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd011385.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000}}],"reference-count":62,"publisher":"Wiley","issue":"4","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd011385.pub3","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T12:06:24Z","timestamp":1555675584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions"],"prefix":"10.1002","volume":"2019","author":[{"given":"Karin PM","family":"van Galen","sequence":"first","affiliation":[{"name":"University Medical Centre Utrecht; Van Creveldkliniek \/ Department of Haematology; Heidelberglaan 100 Utrecht Netherlands 3584CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline T","family":"Engelen","sequence":"additional","affiliation":[{"name":"University Medical Centre Utrecht; Poortstraat 95 Utrecht Netherlands 3572HG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien P","family":"Mauser-Bunschoten","sequence":"additional","affiliation":[{"name":"University Medical Centre Utrecht; Van Creveldkliniek \/ Department of Haematology; Heidelberglaan 100 Utrecht Netherlands 3584CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert JJ","family":"van Es","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht; Oral and Maxillofacial Surgery; Heidelberglaan 100 Utrecht Netherlands 3584CX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger EG","family":"Schutgens","sequence":"additional","affiliation":[{"name":"University Medical Centre Utrecht; Van Creveldkliniek \/ Department of Haematology; Heidelberglaan 100 Utrecht Netherlands 3584CT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,19]]},"reference":[{"issue":"5809","key":"10.1002\/14651858.CD011385.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/bmj.2.5809.311","article-title":"Tranexamic acid in control of haemorrhage after dental extraction in haemophilia and Christmas disease","volume":"2","author":"Forbes","year":"1972","journal-title":"British Medical Journal"},{"issue":"5","key":"10.1002\/14651858.CD011385.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2141.1971.tb07061.x","article-title":"Epsilon-Aminocaproic acid therapy for dental extractions in haemophilia and Christmas disease: a double blind controlled trial","volume":"20","author":"Walsh","year":"1971","journal-title":"British Journal of Haematology"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1055\/s-0038-1647987","article-title":"Re: tranexamic acid and bleeding: a double-blind cross-over study on three brothers with Christmas disease (Factor IX deficiency)","volume":"35","author":"Beck","year":"1976","journal-title":"Thrombosis and Haemostasis"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2141.1973.tb05729.x","article-title":"Antifibrinolytic treatment in haemophilia: a controlled trial of prophylaxis with tranexamic acid","volume":"24","author":"Bennett","year":"1973","journal-title":"British Journal of Haematology"},{"issue":"4","key":"10.1002\/14651858.CD011385.pub3-BIB0005|cit5","first-page":"157","article-title":"Epsilon-aminocaproic acid in the treatment of hemophilia","volume":"124","author":"Biggs","year":"1968","journal-title":"British Dental Journal"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0030-4220(73)90237-5","article-title":"Fibrinolysis: a possible factor in the control of postoperative hemorrhage in the patient with hemophilia","volume":"36","author":"Bump","year":"1973","journal-title":"Oral Surgery, Oral Medicine, and Oral Pathology"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0007|cit7","first-page":"160","article-title":"Topical aminocaproic acid in hemophiliac patients undergoing dental extraction","volume":"24","author":"Casdorph","year":"1990","journal-title":"DICP: The Annals of Pharmacotherapy"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0008|cit8","doi-asserted-by":"crossref","unstructured":"Coetzee MJ The use of topical crushed tranexamic acid tablets to control bleeding after dental surgery and from skin ulcers in haemophilia Haemophilia : The Official Journal of the World Federation of Hemophilia 2007 443 4","DOI":"10.1111\/j.1365-2516.2007.01479.x"},{"issue":"5530","key":"10.1002\/14651858.CD011385.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1136\/bmj.2.5530.1633","article-title":"Epsilon-aminocaproic acid therapy for dental extractions in haemophiliacs","volume":"2","author":"Cooksey","year":"1966","journal-title":"British Medical Journal"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0022-3476(72)80471-2","article-title":"Oral bleeding in hemophilia: treatment with epsilon aminocaproic acid and replacement therapy","volume":"80","author":"Corrigan","year":"1972","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0011|cit11","unstructured":"Evans BE The use of epsilon-aminocaproic acid for the management of hemophilia in dental and oral surgery patients Journal of the American Dental Association (1939) 1977 21"},{"issue":"3","key":"10.1002\/14651858.CD011385.pub3-BIB0012|cit12","first-page":"83","article-title":"The use of epsilon aminocaproic acid as an adjunct to replacement therapy in hemophiliacs undergoing tooth extraction. (Part I)","volume":"51","author":"Evans","year":"1981","journal-title":"The New York Journal of Dentistry"},{"issue":"4","key":"10.1002\/14651858.CD011385.pub3-BIB0013|cit13","first-page":"117","article-title":"The use of epsilon aminocaproic acid as an adjunct to replacement therapy in hemophiliacs undergoing tooth extraction (part II)","volume":"51","author":"Evans","year":"1981","journal-title":"The New York Journal of Dentistry"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1136\/bmj.1.5451.1632","article-title":"Clinical trial of epsilon-aminocaproic acid in severe haemophilia","volume":"1","author":"Gordon","year":"1965","journal-title":"British Medical Journal"},{"issue":"7","key":"10.1002\/14651858.CD011385.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/jcp.25.7.629","article-title":"Tranexamic acid for prophylaxis in haemophilia. [abstract]","volume":"25","author":"Ingram","year":"1972","journal-title":"Journal of Clinical Pathology"},{"issue":"4","key":"10.1002\/14651858.CD011385.pub3-BIB0016|cit16","first-page":"391","article-title":"Use of epsilon-aminocaproic acid in hemophiliacs for dental extractions","volume":"65","author":"Kontras","year":"1969","journal-title":"The Ohio State Medical Journal"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/sj.bdj.4811955","article-title":"Effectiveness in controlling haemorrhage after dental scaling in people with haemophilia by using tranexamic acid mouthwash","volume":"198","author":"Lee","year":"2005","journal-title":"British Dental Journal"},{"issue":"45","key":"10.1002\/14651858.CD011385.pub3-BIB0018|cit18","first-page":"1743","article-title":"An approach to dental extractions in haemophilia and related bleeding disorders in children","volume":"46","author":"Lurie","year":"1972","journal-title":"South African Medical Journal (Suid-Afrikaanse Tydskrif vir Geneeskunde)"},{"issue":"3","key":"10.1002\/14651858.CD011385.pub3-BIB0019|cit19","first-page":"64","article-title":"The use of epsilon aminocaproic acid as supplementary treatment of the haemophiliac undergoing surgery","volume":"22","author":"Paddon","year":"1967","journal-title":"The Journal of the Dental Association of South Africa (Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika)"},{"issue":"4","key":"10.1002\/14651858.CD011385.pub3-BIB0020|cit20","first-page":"153","article-title":"Replacement therapy and local measures for dental extractions in haemophiliacs: comparison of various schemes of treatment","volume":"22","author":"Pizzoni","year":"1971","journal-title":"Rassegna Internazionale di Stomatologia Pratica"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00000441-196408000-00007","article-title":"The use of epsilon-aminocaproic acid in the management of dental extractions in the hemophiliac","volume":"248","author":"Reid","year":"1964","journal-title":"American Journal of the Medical Sciences"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0022|cit22","first-page":"444","article-title":"Tranexamic acid as prophylaxis in haemophilia. A randomized double-blind study [abstract]","volume":"50","author":"Schiavoni","year":"1983","journal-title":"Thrombosis and Haemostasis"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0023|cit23","first-page":"77","article-title":"Extractions in hemophilia. Use of EACA","volume":"57","author":"Short","year":"1974","journal-title":"Minnesota Medicine"},{"issue":"4","key":"10.1002\/14651858.CD011385.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0300-9785(85)80023-5","article-title":"The combined local\/systemic use of antifibrinolytics in hemophiliacs undergoing dental extractions","volume":"14","author":"Stajcic","year":"1985","journal-title":"International Journal of Oral Surgery"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0901-5027(89)80007-4","article-title":"Primary wound closure in haemophiliacs undergoing dental extractions","volume":"18","author":"Stajcic","year":"1989","journal-title":"International Journal of Oral and Maxillofacial Surgery"},{"issue":"5809","key":"10.1002\/14651858.CD011385.pub3-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/bmj.2.5809.314","article-title":"Use of tranexamic acid in control of haemorrhage after extraction of teeth in haemophilia and Christmas disease","volume":"2","author":"Tavenner","year":"1972","journal-title":"British Medical Journal"},{"issue":"12","key":"10.1002\/14651858.CD011385.pub3-BIB0027|cit27","first-page":"594","article-title":"On the oral surgery in hemophilic patients","volume":"21","author":"Verbeck","year":"1967","journal-title":"Deutsche zahnarztliche Zeitschrift"},{"issue":"5577","key":"10.1002\/14651858.CD011385.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/bmj.4.5577.453","article-title":"Double-blind experiments on the effect of a peanut extract on the bleeding incidence in 92 haemophiliacs","volume":"4","author":"Verstraete","year":"1967","journal-title":"British Medical Journal"},{"issue":"6","key":"10.1002\/14651858.CD011385.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/000992286800700602","article-title":"Peanuts and hemophilia","volume":"7","author":"Wolman","year":"1968","journal-title":"Clinical Pediatrics"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0030|cit30","first-page":"961","article-title":"Local antifibrinolytic treatment with tranexamic acid in hemophilic children undergoing dental extractions","volume":"41","author":"Waly","year":"1995","journal-title":"Egyptian Dental Journal"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1834-7819.1988.tb00624.x","article-title":"DDAVP and EACA used for minor oral surgery in von Willebrand disease","volume":"33","author":"Williamson","year":"1988","journal-title":"Australian Dental Journal"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0032|cit32","unstructured":"Windyga J Stefanska-Windyga E Odnoczko E Baran B Czubak G Activated prothrombin complex concentrate in combination with tranexamic acid: a single centre experience for the treatment of mucosal bleeding and dental extraction in haemophilia patients with inhibitors Haemophilia : the official journal of the World Federation of Hemophilia 2016 e465 8"},{"issue":"10","key":"10.1002\/14651858.CD011385.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1182\/blood.V88.10.3815.bloodjournal88103815","article-title":"Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma","volume":"88","author":"Broze","year":"1996","journal-title":"Blood"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0034|cit34","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009961.pub2","article-title":"Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery","author":"Coppola","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0035|cit35","unstructured":"Deeks JJ Higgins JPT Altman DG on behalf of the Cochrane Statistical Methods Group Chapter 9 Analysing data and undertaking meta-analysis. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-2516.2000.00370.x","article-title":"Optimising local therapy during oral surgery in patients with von Willebrand disease: effective results from a retrospective analysis of 63 cases","volume":"6","author":"Federici","year":"2000","journal-title":"Haemophilia : the official journal of the World Federation of Hemophilia"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/1756-0500-6-184","article-title":"Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis","volume":"6","author":"Gandhi","year":"2013","journal-title":"BMC Research Notes"},{"issue":"3","key":"10.1002\/14651858.CD011385.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1365-2516.2008.01950.x","article-title":"Replacement therapy for invasive procedures in patients with haemophilia: literature review, European survey and recommendations","volume":"15","author":"Hermans","year":"2009","journal-title":"Haemophilia : the official journal of the World Federation of Hemophilia"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1111\/j.1365-2516.2010.02346.x","article-title":"Dental surgery with minimal factor support in the inherited bleeding disorder population at the Alfred Hospital","volume":"17","author":"Hewson","year":"2011","journal-title":"Haemophilia : the official journal of the World Federation of Hemophilia"},{"issue":"7414","key":"10.1002\/14651858.CD011385.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0041|cit41","unstructured":"Higgins JPT Deeks JJ (editors) Chapter 7: Selecting studies and collecting data. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0042|cit42","unstructured":"Higgins JPT Altman DG Sterne JAC on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group (editors) Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0043|cit43","unstructured":"Higgins JPT Deeks JJ Altman DG on behalf of the Cochrane Statistical Methods Group (editors) Chapter 16: Special topics in statistics. In: Higgins JPT, Green S (editors). Cochrane Handbook of Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"4","key":"10.1002\/14651858.CD011385.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0003-4975(96)00022-7","article-title":"Tranexamic acid reduces postbypass blood use: a double-blinded, prospective, randomised study of 210 patients","volume":"61","author":"Katsaros","year":"1996","journal-title":"Annals of Thoracic Surgery"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1182\/blood-2013-07-498261","article-title":"Molecular approaches for improved clotting factors for hemophilia.","volume":"122","author":"Kaufman","year":"2013","journal-title":"Blood"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ejcts.2008.11.038","article-title":"Tranexamic acid and aprotinin in low- and intermediate-risk cardiac surgery: a non-sponsored, double-blind, randomised, placebo-controlled trial","volume":"36","author":"Later","year":"2009","journal-title":"European Journal of Cardio-thoracic Surgery"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0047|cit47","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The\u00a0PRISMA\u00a0statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati\u00a0A","year":"2009","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD011385.pub3-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/021849230701500410","article-title":"Tranexamic acid and primary coronary artery bypass surgery: a prospective study","volume":"15","author":"Maddali","year":"2007","journal-title":"Asian Cardiovascular & Thorac Annals"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1600-0501.2009.01770.x","article-title":"What influence do anticoagulants have on oral implant therapy? A systematic review","volume":"20 Suppl 4","author":"Madrid","year":"2009","journal-title":"Clinical Oral Implants Research"},{"issue":"5","key":"10.1002\/14651858.CD011385.pub3-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2165\/11209070-000000000-00000","article-title":"Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis","volume":"72","author":"McCormack","year":"2012","journal-title":"Drugs"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0007-117X(73)90035-8","article-title":"Tranexamic acid - its use in controlling dental post-operative bleeding in patients with defective clotting mechanisms","volume":"11","author":"Pell","year":"1973","journal-title":"The British Journal of Oral Surgery"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0052|cit52","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010245.pub2","article-title":"Tranexamic acid for reducing mortality in emergency and urgent surgery","author":"Perel","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD011385.pub3-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0901-5027(89)80026-8","article-title":"Oral surgery in patients with hereditary bleeding disorders. A survey of treatment in the Stockholm area (1974-1985)","volume":"18","author":"Ramstrom","year":"1989","journal-title":"International Journal of Oral & Maxillofacial Surgery"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0054|cit54","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2011"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","article-title":"Epidemiological investigation of the prevalence of von Willebrand's disease","volume":"69","author":"Rodeghiero","year":"1987","journal-title":"Blood"},{"issue":"2","key":"10.1002\/14651858.CD011385.pub3-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0030-4220(81)90025-6","article-title":"Epsilon aminocaproic acid in hemophiliacs undergoing dental extractions: a concise review","volume":"51","author":"Shira","year":"1981","journal-title":"Oral Surgery"},{"issue":"13","key":"10.1002\/14651858.CD011385.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJM198903303201305","article-title":"Hemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery","volume":"320","author":"Sindet-Pedersen","year":"1989","journal-title":"New England Journal of Medicine"},{"issue":"6","key":"10.1002\/14651858.CD011385.pub3-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1177\/00220345900690061201","article-title":"The possible role of oral epithelial cells in tissue-type plasminogen activator-related fibrinolysis in human saliva","volume":"69","author":"Sindet-Pedersen","year":"1990","journal-title":"Journal of Dental Research"},{"issue":"1","key":"10.1002\/14651858.CD011385.pub3-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2516.2009.02127.x","article-title":"A study of variations in the reported haemophilia A prevalence around the world","volume":"16","author":"Stonebraker","year":"2010","journal-title":"Haemophilia"},{"key":"10.1002\/14651858.CD011385.pub3-BIB0060|cit60","unstructured":"World Federation of Hemophilia Guidelines for the management of hemophilia, 2nd edition http:\/\/www1.wfh.org\/publication\/files\/pdf-1472.pdf"},{"issue":"12","key":"10.1002\/14651858.CD011385.pub3-BIB0061|cit61","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011385","article-title":"Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions","author":"Galen","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD011385.pub3-BIB0062|cit62","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011385.pub2","article-title":"Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions","author":"Galen","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD011385.pub3\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:20:01Z","timestamp":1782980401000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD011385.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Cystic Fibrosis and Genetic Disorders Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,19]]},"references-count":62,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd011385.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,19]]}}}