{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:11:58Z","timestamp":1767136318396,"version":"build-2238731810"},"update-to":[{"DOI":"10.1002\/14651858.cd011647","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000}}],"reference-count":77,"publisher":"Wiley","issue":"4","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd011647.pub2","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T13:30:01Z","timestamp":1488979801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interventions for hereditary haemochromatosis"],"prefix":"10.1002","volume":"2017","author":[{"given":"Elena","family":"Buzzetti","sequence":"first","affiliation":[{"name":"Royal Free Hospital and the UCL Institute of Liver and Digestive Health; Sheila Sherlock Liver Centre; London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kalafateli","sequence":"additional","affiliation":[{"name":"Royal Free Hospital and the UCL Institute of Liver and Digestive Health; Sheila Sherlock Liver Centre; London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Thorburn","sequence":"additional","affiliation":[{"name":"Royal Free Hospital and the UCL Institute of Liver and Digestive Health; Sheila Sherlock Liver Centre; London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian R","family":"Davidson","sequence":"additional","affiliation":[{"name":"Royal Free Campus, UCL Medical School; Department of Surgery; Pond Street London UK NW3 2QG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Tsochatzis","sequence":"additional","affiliation":[{"name":"Royal Free Hospital and the UCL Institute of Liver and Digestive Health; Sheila Sherlock Liver Centre; London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurinchi Selvan","family":"Gurusamy","sequence":"additional","affiliation":[{"name":"Royal Free Campus, UCL Medical School; Department of Surgery; Pond Street London UK NW3 2QG"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,8]]},"reference":[{"issue":"3","key":"10.1002\/14651858.CD011647.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1537-2995.2011.03292.x","article-title":"Erythrocytapheresis versus phlebotomy in the initial treatment of HFE hemochromatosis patients: results from a randomized trial","volume":"52","author":"Rombout-Sestrienkova","year":"2012","journal-title":"Transfusion"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.transci.2009.01.008","article-title":"Therapeutic erythrocytapheresis (TE) versus phlebotomy (P) in the treatment of hereditary hemochromatosis (HH) patients: preliminary results from an ongoing randomized clinical trial (NCT 00202436)","volume":"40","author":"Rombout-Sestrienkova","year":"2009","journal-title":"Transfusion and Apheresis Science"},{"issue":"1","key":"10.1002\/14651858.CD011647.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/trf.13328","article-title":"Erythrocytapheresis versus phlebotomy in the maintenance treatment of HFE hemochromatosis patients: results from a randomized crossover trial","volume":"56","author":"Rombout-Sestrienkova","year":"2016","journal-title":"Transfusion"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD011647.pub2-BIB0004|cit4","first-page":"S84","article-title":"Erythrocytapheresis compared with whole blood phlebotomy for the treatment of hereditary haemochromatosis","volume":"12","author":"Sundic","year":"2014","journal-title":"Blood Transfusion"},{"issue":"8","key":"10.1002\/14651858.CD011647.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"e008938","DOI":"10.1136\/bmjopen-2015-008938","article-title":"Should HFE p.C282y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron)","volume":"5","author":"Ong","year":"2015","journal-title":"BMJ Open"},{"issue":"9602","key":"10.1002\/14651858.CD011647.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/S0140-6736(07)61782-6","article-title":"Haemochromatosis","volume":"370","author":"Adams","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD011647.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa073286","article-title":"Iron-overload-related disease in HFE hereditary hemochromatosis","volume":"358","author":"Allen","year":"2008","journal-title":"New England Journal of Medicine"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD011647.pub2-BIB0008|cit8","first-page":"s75","article-title":"Current applications of therapeutic phlebotomy","volume":"12","author":"Assi","year":"2014","journal-title":"Blood Transfusion"},{"issue":"1","key":"10.1002\/14651858.CD011647.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.24330","article-title":"Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases","volume":"54","author":"Bacon","year":"2011","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.hoc.2014.04.006","article-title":"Diagnostic evaluation of hereditary hemochromatosis (HFE and non-HFE)","volume":"28","author":"Bardou-Jacquet","year":"2014","journal-title":"Hematology\/Oncology Clinics of North America"},{"issue":"9302","key":"10.1002\/14651858.CD011647.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0140-6736(02)07447-0","article-title":"Penetrance of 845G \u2192 A (C282Y) HFE hereditary haemochromatosis mutation in the USA","volume":"359","author":"Beutler","year":"2002","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/096914139600300404","article-title":"Population screening for haemochromatosis: a unifying analysis of published intervention trials","volume":"3","author":"Bradley","year":"1996","journal-title":"Journal of Medical Screening"},{"issue":"6","key":"10.1002\/14651858.CD011647.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/ejh.12530","article-title":"Deferasirox in patients with iron overload secondary to hereditary hemochromatosis: results of a 1-year Phase 2 study","volume":"95","author":"Cancado","year":"2015","journal-title":"European Journal of Haematology"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0168-8278(01)00035-6","article-title":"Frequency and biochemical expression of C282Y\/H63D hemochromatosis (HFE) gene mutations in the healthy adult population in Italy","volume":"34","author":"Cassanelli","year":"2001","journal-title":"Journal of Hepatology"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/jrsm.57","article-title":"Using network meta-analysis to evaluate the existence of small-study effects in a network of interventions","volume":"3","author":"Chaimani","year":"2012","journal-title":"Research Synthesis Methods"},{"issue":"10","key":"10.1002\/14651858.CD011647.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"e76654","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"Chaimani","year":"2013","journal-title":"PloS one"},{"issue":"3","key":"10.1002\/14651858.CD011647.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7326\/0003-4819-158-3-201302050-00583","article-title":"SPIRIT 2013 statement: defining standard protocol items for clinical trials","volume":"158","author":"Chan","year":"2013","journal-title":"Annals of Internal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD011647.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s40258-015-0189-y","article-title":"A systematic review and narrative synthesis of health economic studies conducted for hereditary haemochromatosis","volume":"13","author":"Graaff","year":"2015","journal-title":"Applied Health Economics and Health Policy"},{"issue":"6","key":"10.1002\/14651858.CD011647.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"e63509","DOI":"10.1371\/journal.pone.0063509","article-title":"Efficacy of new generation antidepressants: differences seem illusory","volume":"8","author":"Re","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1002\/14651858.CD011647.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/sim.4780060325","article-title":"Methods for combining randomized clinical trials: strengths and limitations","volume":"6","author":"DeMets","year":"1987","journal-title":"Statistics in Medicine"},{"issue":"3","key":"10.1002\/14651858.CD011647.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"issue":"7-8","key":"10.1002\/14651858.CD011647.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/sim.3767","article-title":"Checking consistency in mixed treatment comparison meta-analysis","volume":"29","author":"Dias","year":"2010","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0023|cit23","unstructured":"Dias S Sutton AJ Welton NJ Ades AE NICE DSU Technical Support Document 3: heterogeneity: subgroups, meta-regression, bias and bias-adjustment, September 2011 (last updated April 2012) www.nicedsu.org.uk\/TSD3%20Heterogeneity.final%20report.08.05.12.pdf"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0024|cit24","unstructured":"Dias S Welton NJ Sutton AJ Ades AE NICE DSU Technical Support Document 1: introduction to evidence synthesis for decision making, April 2011 (last updated April 2012) www.nicedsu.org.uk\/TSD1%20Introduction.final.08.05.12.pdf"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0025|cit25","unstructured":"Dias S Welton NJ Sutton AJ Ades AE NICE DSU Technical Support Document 2: a generalised linear modelling framework for pairwise and network meta-analysis of randomised controlled trials, August 2011 (last updated April 2014) www.nicedsu.org.uk\/TSD2%20General%20meta%20analysis%20corrected%2015April2014.pdf"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0026|cit26","unstructured":"Dias S Welton NJ Sutton AJ Caldwell DM Lu G Ades AE NICE DSU Technical Support Document 4: inconsistency in networks of evidence based on randomised controlled trials, May 2011 (last updated April 2014) www.nicedsu.org.uk\/TSD4%20Inconsistency.final.15April2014.pdf"},{"issue":"1","key":"10.1002\/14651858.CD011647.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jhep.2010.03.001","article-title":"EASL clinical practice guidelines for HFE hemochromatosis","volume":"53","author":"European Association for the Study of the Liver","year":"2010","journal-title":"Journal of Hepatology"},{"issue":"7109","key":"10.1002\/14651858.CD011647.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/hep.21885","article-title":"Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls","volume":"46","author":"Ellervik","year":"2007","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0030|cit30","unstructured":"EuroQol About EQ-5D, 2014 www.euroqol.org\/about-eq-5d.html"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng0896-399","article-title":"A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis","volume":"13","author":"Feder","year":"1996","journal-title":"Nature Genetics"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0032|cit32","unstructured":"Gluud C Nikolova D Klingenberg SL. Cochrane Hepato-Biliary Group About Cochrane (Cochrane Review Groups (CRGs)) 2015, Issue 11. Art. No.: LIVER"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0034|cit34","unstructured":"Higgins JPT Green S editor(s) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.handbook.cochrane.org"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/jrsm.1044","article-title":"Consistency and inconsistency in network meta-analysis: Concepts and models for multi-arm studies","volume":"3","author":"Higgins","year":"2012","journal-title":"Research Synthesis Methods"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0036|cit36","volume-title":"International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonised tripartite guideline. Guideline for good clinical practice CFR & ICH Guidelines","volume":"1","author":"International Conference on Harmonisation Expert Working Group","year":"1997"},{"issue":"1","key":"10.1002\/14651858.CD011647.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1471-2288-14-120","article-title":"Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods","volume":"14","author":"Jakobsen","year":"2014","journal-title":"BMC Medical Research Methodology"},{"issue":"11","key":"10.1002\/14651858.CD011647.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7326\/0003-4819-135-11-200112040-00010","article-title":"Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses","volume":"135","author":"Kjaergard","year":"2001","journal-title":"Annals of Internal Medicine"},{"issue":"474","key":"10.1002\/14651858.CD011647.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1198\/016214505000001302","article-title":"Assessing evidence inconsistency in mixed treatment comparisons","volume":"101","author":"Lu","year":"2006","journal-title":"Journal of the American Statistical Association"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1079-9796(03)00133-5","article-title":"A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?","volume":"31","author":"Lucotte","year":"2003","journal-title":"Blood, Cells, Molecules & Diseases"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0041|cit41","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.MR000033.pub3","article-title":"Industry sponsorship and research outcome","author":"Lundh","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/sim.698","article-title":"A comparison of methods to detect publication bias in meta-analysis","volume":"20","author":"Macaskill","year":"2001","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0043|cit43","unstructured":"Sweetman S editor Martindale: the complete drug reference (online version), 37th edition, 2011 www.pharmpress.com\/product\/MC_MART\/martindale-the-complete-drug-reference"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/bcmd.1998.0183","article-title":"Frequency of the C282Y mutation of hemochromatosis in five French populations","volume":"24","author":"Mercier","year":"1998","journal-title":"Blood, Cells, Molecules & Diseases"},{"issue":"12","key":"10.1002\/14651858.CD011647.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1001\/2012.jama.11228","article-title":"How to use an article reporting a multiple treatment comparison meta-analysis","volume":"308","author":"Mills","year":"2012","journal-title":"JAMA"},{"issue":"9128","key":"10.1002\/14651858.CD011647.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(98)01085-X","article-title":"Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?","volume":"352","author":"Moher","year":"1998","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD011647.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/ije\/21.5.837","article-title":"Intention-to-treat analysis: implications for quantitative and qualitative research","volume":"21","author":"Newell","year":"1992","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0048|cit48","unstructured":"Members of OpenBUGS Project Management Group OpenBUGS 2014"},{"issue":"10","key":"10.1002\/14651858.CD011647.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1182\/blood-2013-04-497842","article-title":"A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in beta-thalassemia major (CORDELIA)","volume":"123","author":"Pennell","year":"2014","journal-title":"Blood"},{"issue":"23","key":"10.1002\/14651858.CD011647.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1056\/NEJMra031573","article-title":"Hereditary hemochromatosis - a new look at an old disease","volume":"350","author":"Pietrangelo","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0051|cit51","first-page":"g5630","article-title":"A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis","volume":"349","author":"Puhan","year":"2014","journal-title":"BMJ (Clinical Research Ed.)"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0052|cit52","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"5","key":"10.1002\/14651858.CD011647.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00277-006-0094-4","article-title":"Frequency of the C282Y and H63D mutations of the hemochromatosis gene (HFE) in a cohort of 1,000 neonates in Madrid (Spain)","volume":"85","author":"Ropero","year":"2006","journal-title":"Annals of Hematology"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1017\/S0266462303000552","article-title":"Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches","volume":"19","author":"Royle","year":"2003","journal-title":"International Journal of Technology Assessment in Health Care"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial","volume":"64","author":"Salanti","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jrsm.1037","article-title":"Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool","volume":"3","author":"Salanti","year":"2012","journal-title":"Research Synthesis Methods"},{"issue":"35","key":"10.1002\/14651858.CD011647.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta16350","article-title":"Influence of reported study design characteristics on intervention effect estimates from randomized controlled trials: combined analysis of meta-epidemiological studies","volume":"16","author":"Savovi\u0107","year":"2012","journal-title":"Health Technology Assessment"},{"issue":"6","key":"10.1002\/14651858.CD011647.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"429","DOI":"10.7326\/0003-4819-157-6-201209180-00537","article-title":"Influence of reported study design characteristics on intervention effect estimates from randomized controlled trials","volume":"157","author":"Savovi\u0107","year":"2012","journal-title":"Annals of Internal Medicine"},{"issue":"7","key":"10.1002\/14651858.CD011647.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"522","DOI":"10.7326\/0003-4819-143-7-200510040-00011","article-title":"Screening primary care patients for hereditary hemochromatosis with transferrin saturation and serum ferritin level: systematic review for the American College of Physicians","volume":"143","author":"Schmitt","year":"2005","journal-title":"Annals of Internal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD011647.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"c332","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"2","key":"10.1002\/14651858.CD011647.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.2517-6161.1993.tb01921.x","article-title":"Bayesian interval estimates which are also confidence intervals","volume":"55","author":"Severini","year":"1993","journal-title":"Journal of the Royal Statistical Society. Series B (Methodological)"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0063|cit63","unstructured":"StataCorp LP Stata\/SE 14.2 for Windows[64-bit x86-64] 2017"},{"issue":"17","key":"10.1002\/14651858.CD011647.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1001\/jama.285.17.2216","article-title":"Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States","volume":"285","author":"Steinberg","year":"2001","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0065|cit65","unstructured":"Thorlund K Engstr\u00f8m J Wetterslev J Brok J Imberger G Gluud C User manual for trial sequential analysis (TSA). Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark. 2011. p. 1-115 Available from www.ctu.dk\/tsa"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/2046-4053-1-41","article-title":"Sample size and power considerations in network meta-analysis","volume":"1","author":"Thorlund","year":"2012","journal-title":"Systematic Reviews"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0067|cit67","unstructured":"Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen TSA version 0.9 2011"},{"issue":"3","key":"10.1002\/14651858.CD011647.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/ije\/dys041","article-title":"Predicting the extent of heterogeneity in meta-analysis, using empirical data from the Cochrane Database of Systematic Reviews","volume":"41","author":"Turner","year":"2012","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"c7251","DOI":"10.1136\/bmj.c7251","article-title":"Diagnosis and management of hereditary haemochromatosis","volume":"342","author":"Bokhoven","year":"2011","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"4","key":"10.1002\/14651858.CD011647.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jrsm.1054","article-title":"Automating network meta-analysis","volume":"3","author":"Valkenhoef","year":"2012","journal-title":"Research Synthesis Methods"},{"issue":"3","key":"10.1002\/14651858.CD011647.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2141.2006.06455.x","article-title":"A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease","volume":"136","author":"Vichinsky","year":"2007","journal-title":"British Journal of Haematology"},{"issue":"1","key":"10.1002\/14651858.CD011647.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bcmd.2008.08.004","article-title":"Prevalence of HFE (hemochromatosis) gene mutations C282Y and H63D in a Romanian population","volume":"42","author":"Voicu","year":"2009","journal-title":"Blood, Cells, Molecules & Diseases"},{"key":"10.1002\/14651858.CD011647.pub2-BIB0073|cit73","unstructured":"Ware JE SF-36\u00ae health survey update, 2014 www.sf-36.org\/tools\/sf36.shtml"},{"issue":"1","key":"10.1002\/14651858.CD011647.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jclinepi.2007.03.013","article-title":"Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis","volume":"61","author":"Wetterslev","year":"2008","journal-title":"Journal of Clinical Epidemiology"},{"issue":"3","key":"10.1002\/14651858.CD011647.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"209","DOI":"10.7326\/0003-4819-145-3-200608010-00009","article-title":"Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force","volume":"145","author":"Whitlock","year":"2006","journal-title":"Annals of Internal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD011647.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1155\/2002\/161569","article-title":"Natural history of C282Y homozygotes for hemochromatosis","volume":"16","author":"Wojcik","year":"2002","journal-title":"Canadian Journal of Gastroenterology"},{"issue":"7644","key":"10.1002\/14651858.CD011647.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/bmj.39465.451748.AD","article-title":"Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study","volume":"336","author":"Wood","year":"2008","journal-title":"BMJ (Clinical Research Ed.)"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD011647.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T02:05:11Z","timestamp":1703469911000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD011647.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Hepato-Biliary Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,8]]},"references-count":77,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd011647.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,8]]}}}