{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:28:53Z","timestamp":1792427333483,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd012157","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000}}],"reference-count":117,"publisher":"Wiley","issue":"10","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd012157.pub2","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T11:57:47Z","timestamp":1666353467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antidepressants for hip and knee osteoarthritis"],"prefix":"10.1002","volume":"2022","author":[{"given":"Alexandra A","family":"Leaney","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine; Monash University; Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna R","family":"Lyttle","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine; Monash University; Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Segan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine; Monash University; Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M","family":"Urquhart","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine; Monash University; Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia M","family":"Cicuttini","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine; Monash University; Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine; Monash University; Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita E","family":"Wluka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine; Monash University; Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0001|cit1","first-page":"250","article-title":"Duloxetine 60 to 120 mg once daily versus placebo in the treatment of patients with osteoarthritis knee pain","volume":"10","author":"Chappell","year":"2009","journal-title":"Pain Medicine"},{"issue":"3","key":"10.1002\/14651858.CD012157.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pain.2009.06.024","article-title":"Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial","volume":"146","author":"Chappell","year":"2009","journal-title":"Pain"},{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1533-2500.2010.00401.x","article-title":"A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee","volume":"11","author":"Chappell","year":"2011","journal-title":"Pain Practice"},{"issue":"10 Suppl","key":"10.1002\/14651858.CD012157.pub2-BIB0004|cit4","first-page":"1","article-title":"The efficacy and safety of duloxetine treatment in older patients with osteoarthritis knee pain: a post hoc, subgroup analysis of data from 2 placebo-controlled trials","volume":"63","author":"Micca","year":"2011","journal-title":"Arthritis and Rheumatism"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1471-2474-14-137","article-title":"Safety and efficacy of duloxetine treatment in older and younger patients with osteoarthritis knee pain: a post hoc, subgroup analysis of two randomized, placebo-controlled trials","volume":"14","author":"Micca","year":"2013","journal-title":"BMC Musculoskeletal Disorders"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0006|cit6","first-page":"822","article-title":"Erratum: duloxetine added to nonsteroidal antiinflammatory drugs for treatment of knee pain due to osteoarthritis: results of a randomized, double-blind, placebo-controlled trial (Current Medical Research and Opinion (2011) 27:12 (1-12))","volume":"28","author":"Frakes","year":"2012","journal-title":"Current Medical Research and Opinion"},{"issue":"12","key":"10.1002\/14651858.CD012157.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1185\/03007995.2011.633502","article-title":"Duloxetine added to oral nonsteroidal anti-inflammatory drugs for treatment of knee pain due to osteoarthritis: results of a randomized, double-blind, placebo-controlled trial. [Erratum appears in Current Medical Research & Opinion 2012;28(5):822]","volume":"27","author":"Frakes","year":"2011","journal-title":"Current Medical Research & Opinion"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.joca.2013.02.007","article-title":"Responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) scale in a trial of duloxetine for treatment of osteoarthritis knee pain","volume":"21","author":"Risser","year":"2013","journal-title":"Osteoarthritis and Cartilage"},{"issue":"Suppl 10","key":"10.1002\/14651858.CD012157.pub2-BIB0009|cit9","first-page":"2758","article-title":"Nortriptyline in knee arthritis (Nortika): a randomised controlled double blind trial of nortriptyline for pain in knee osteoarthritis [abstract]","volume":"71","author":"Hudson","year":"2019","journal-title":"Arthritis & Rheumatology"},{"issue":"708","key":"10.1002\/14651858.CD012157.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.3399\/BJGP.2020.0797","article-title":"Nortriptyline for pain in knee osteoarthritis in general practice: a double blind randomised controlled trial","volume":"71","author":"Hudson","year":"2021","journal-title":"British Journal of General Practise"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0011|cit11","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1186\/s13063-015-0961-1","article-title":"Nortriptyline in knee osteoarthritis (NortIKA study): study protocol for a randomised controlled trial","volume":"16","author":"Hudson","year":"2015","journal-title":"Trials"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.jpain.2013.01.600","article-title":"Functional testing and pre-to post pain measure outcomes in chronic knee osteoarthritis pain with milnacipran: interim analysis of a randomized, double-blind, placebo-controlled trial","volume":"1","author":"Mathur","year":"2013","journal-title":"Journal of Pain"},{"issue":"6","key":"10.1002\/14651858.CD012157.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1055\/s-2008-1039038","article-title":"Additional treatment in chronic pain syndrome due to hip and knee arthritis with the selective serotonin reuptake inhibitor fluvoxamine (Fevarin)","volume":"146","author":"Riesner","year":"2008","journal-title":"Zeitschrift fur Orthopadie & Unfallchirurgie"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0014|cit14","first-page":"S410","article-title":"Cortical reorganization after duloxetine treatment-related pain decrease in knee osteoarthritis","volume":"66","author":"Tetreault","year":"2014","journal-title":"Arthritis and Rheumatology"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1371\/journal.pbio.1002570","article-title":"Brain connectivity predicts placebo response across chronic pain clinical trials","volume":"14","author":"Tetreault","year":"2016","journal-title":"PLOS Biology"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0016|cit16","unstructured":"An open label extension study of phase 3 trial of duloxetine in patients with osteoarthritis and knee pain clinicaltrials.gov\/ct2\/show\/NCT02335346"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2147\/JPR.S164128","article-title":"A randomized, double-blind, placebo-controlled phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis","volume":"11","author":"Uchio","year":"2018","journal-title":"Journal of Pain Research"},{"issue":"6","key":"10.1002\/14651858.CD012157.pub2-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.joca.2016.12.025","article-title":"Efficacy and safety of duloxetine in Chinese patients with chronic pain due to osteoarthritis: a randomized, double-blind, placebo-controlled study","volume":"25","author":"Wang","year":"2017","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1016\/j.jpain.2013.01.583","article-title":"Safety of duloxetine for the treatment of older patients with osteoarthritis knee pain or chronic low back pain","volume":"1","author":"Alaka","year":"2013","journal-title":"Journal of Pain"},{"issue":"3","key":"10.1002\/14651858.CD012157.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/AAP.0b013e3181df2645","article-title":"Duloxetine: a review of its pharmacology and use in chronic pain management","volume":"35","author":"Bellingham","year":"2010","journal-title":"Regional Anesthesia and Pain Medicine"},{"issue":"6","key":"10.1002\/14651858.CD012157.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/1759720X13508508","article-title":"Clinical experience with duloxetine in the management of chronic musculoskeletal pain. A focus on osteoarthritis of the knee","volume":"5","author":"Brown","year":"2013","journal-title":"Therapeutic Advances in Musculoskeletal Disease"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2165\/11319200-000000000-00000","article-title":"Profile of adverse events with duloxetine treatment: a pooled analysis of placebo-controlled studies","volume":"33","author":"Brunton","year":"2010","journal-title":"Drug Safety"},{"issue":"12","key":"10.1002\/14651858.CD012157.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1111\/imj.14327","article-title":"Efficacy and tolerability of duloxetine in patients with knee osteoarthritis: a meta-analysis of randomized controlled trials","volume":"49","author":"Chen","year":"2019","journal-title":"Internal Medicine Journal"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1742-1241.2012.02899.x","article-title":"Antidepressants and the relief of osteoarthritic pain \u2013 findings from a study examining adjunctive duloxetine","volume":"66","author":"Citrome","year":"2012","journal-title":"International Journal of Clinical Practice"},{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3810\/pgm.2012.01.2521","article-title":"A systematic review of duloxetine for osteoarthritic pain: what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed?","volume":"124","author":"Citrome","year":"2012","journal-title":"Postgraduate Medicine"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"S287","DOI":"10.1016\/j.joca.2012.02.496","article-title":"Exploratory analysis of osteoarthritis progression among medication users: data from the osteoarthritis initiative","volume":"20","author":"Driban","year":"2012","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"m4825","DOI":"10.1136\/bmj.m4825","article-title":"Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis","volume":"372","author":"Ferreira","year":"2021","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/07853890008995932","article-title":"Evidence-based data on pain relief with antidepressants (structured abstract)","volume":"32","author":"Fishbain","year":"2000","journal-title":"Annals of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0029|cit29","first-page":"288","article-title":"Outcomes in osteoarthritis (OA): analysis of pooled data from randomized placebo-controlled clinical trials of duloxetine in patients with knee OA","volume":"11","author":"Gaynor","year":"2010","journal-title":"Pain Medicine"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1185\/03007995.2013.784191","article-title":"Comparison of safety outcomes among Caucasian, Hispanic, Black, and Asian patients in duloxetine studies of chronic painful conditions","volume":"29","author":"Gaynor","year":"2013","journal-title":"Current Medical Research and Opinion"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1016\/S1063-4584(11)60346-4","article-title":"Duloxetine as treatment for knee pain in patients with osteoarthritis who regularly use nonsteroidal anti-inflammatory drugs (NSAIDS): a post hoc analysis of two randomized, placebo-controlled trials","volume":"19","author":"Hochberg","year":"2011","journal-title":"Osteoarthritis and Cartilage"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3899\/jrheum.110307","article-title":"Clinically relevant outcomes based on analysis of pooled data from 2 trials of duloxetine in patients with knee osteoarthritis","volume":"39","author":"Hochberg","year":"2012","journal-title":"Journal of Rheumatology"},{"issue":"18","key":"10.1002\/14651858.CD012157.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1001\/jama.290.18.2428","article-title":"Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial","volume":"290","author":"Lin","year":"2003","journal-title":"JAMA"},{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/j.1532-2149.2013.00341.x","article-title":"Duloxetine use in chronic painful conditions \u2013 individual patient data responder analysis","volume":"18","author":"Moore","year":"2014","journal-title":"European Journal of Pain"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"A33","DOI":"10.1016\/j.jval.2012.03.191","article-title":"The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a meta-analysis","volume":"15","author":"Myers","year":"2012","journal-title":"Value in Health"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3904\/kjim.2018.460","article-title":"Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis","volume":"34","author":"Osani","year":"2019","journal-title":"Korean Journal of Internal Medicine"},{"issue":"9","key":"10.1002\/14651858.CD012157.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1185\/03007995.2013.816275","article-title":"Utilization of duloxetine and celecoxib in osteoarthritis patients","volume":"29","author":"Peng","year":"2013","journal-title":"Current Medical Research & Opinion"},{"issue":"3","key":"10.1002\/14651858.CD012157.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1533-2500.2012.00578.x","article-title":"A review of duloxetine 60mg once-daily dosing for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain due to chronic osteoarthritis pain and low back pain","volume":"13","author":"Pergolizzi","year":"2013","journal-title":"Pain Practice"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0039|cit39","first-page":"62","article-title":"Cymbalta. Also controls the pain of knee arthrosis","volume":"10","author":"Sabourin","year":"2013","journal-title":"Perspective Infirmiere: Revue Officielle de l'Ordre des Infirmieres et Infirmiers du Quebec"},{"issue":"7A","key":"10.1002\/14651858.CD012157.pub2-BIB0040|cit40","first-page":"S635","article-title":"Recent findings surrounding topical antidepressants as analgesics and review of existing and emerging topical analgesics","volume":"3","author":"Sawynok","year":"2003","journal-title":"Advanced Studies in Medicine"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.jpain.2009.01.149","article-title":"Efficacy and safety of duloxetine in the treatment of pain associated with knee osteoarthritis","volume":"1","author":"Skljarevski","year":"2009","journal-title":"Journal of Pain"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2174\/157488511798109592","article-title":"Efficacy of duloxetine in patients with chronic pain conditions","volume":"6","author":"Skljarevski","year":"2011","journal-title":"Current Drug Therapy"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.2147\/JPR.S147640","article-title":"The effect of pregabalin or duloxetine on arthritis pain: a clinical and mechanistic study in people with hand osteoarthritis","volume":"10","author":"Sofat","year":"2017","journal-title":"Journal of Pain Research"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1526-4637.2009.00637.x","article-title":"A single-blind placebo run-in study of venlafaxine XR for activity-limiting osteoarthritis pain","volume":"10","author":"Sullivan","year":"2009","journal-title":"Pain Medicine"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jpain.2008.08.009","article-title":"A single-blind, placebo run-in study of duloxetine for activity-limiting osteoarthritis pain","volume":"10","author":"Sullivan","year":"2009","journal-title":"Journal of Pain"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0046|cit46","first-page":"S30","article-title":"Efficacy of duloxetine in patients with chronic pain conditions","volume":"1","author":"Talati","year":"2010","journal-title":"PM and R"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"S232","DOI":"10.1016\/S1063-4584(11)60529-3","article-title":"Evidence-based recommendations on duloxetine treatment for the pain in knee and hip osteoarthritis: systematic review and expert consensus","volume":"19","author":"Teran Estrada","year":"2011","journal-title":"Osteoarthritis and Cartilage"},{"issue":"8","key":"10.1002\/14651858.CD012157.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"264","DOI":"10.5694\/j.1326-5377.1974.tb93144.x","article-title":"The role of an antidepressant, dibenzepin (Noveril), in the relief of pain in chronic arthritic states","volume":"1","author":"Thorpe","year":"1974","journal-title":"Medical Journal of Australia"},{"issue":"7","key":"10.1002\/14651858.CD012157.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/pme.12800","article-title":"Efficacy and safety of duloxetine on osteoarthritis knee pain: a meta-analysis of randomized controlled trials","volume":"16","author":"Wang","year":"2015","journal-title":"Pain Medicine (United States)"},{"issue":"6","key":"10.1002\/14651858.CD012157.pub2-BIB0050|cit50","first-page":"721","article-title":"Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain: a systematic review and meta-analysis","volume":"28","author":"Weng","year":"2020","journal-title":"OARSI"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.clinthera.2014.02.009","article-title":"Onset of response with duloxetine treatment in patients with osteoarthritis knee pain and chronic low back pain: a post hoc analysis of placebo-controlled trials","volume":"36","author":"Williamson","year":"2014","journal-title":"Clinical Therapeutics"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1176\/appi.psy.50.4.402","article-title":"Duloxetine for the treatment of recurrent major depressive disorder in elderly patients: treatment outcomes in patients with comorbid arthritis","volume":"50","author":"Wohlreich","year":"2009","journal-title":"Psychosomatics: Journal of Consultation and Liaison Psychiatry"},{"issue":"8","key":"10.1002\/14651858.CD012157.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1185\/03007995.2013.806889","article-title":"Duloxetine dose escalation in patients with osteoarthritis knee pain, who were taking optimized NSAIDs","volume":"29","author":"Wohlreich","year":"2013","journal-title":"Current Medical Research and Opinion"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/ageing\/afs072","article-title":"Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial","volume":"41","author":"Abou-Raya","year":"2012","journal-title":"Age and Aging"},{"issue":"2 Suppl","key":"10.1002\/14651858.CD012157.pub2-BIB0055|cit55","first-page":"20","article-title":"A clinical trial of tofranil in osteo-arthritis","volume":"4","author":"Glick","year":"1976","journal-title":"Journal of International Medical Research"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0056|cit56","unstructured":"Does amitriptyline reduce pain in knee osteoarthritis?"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0057|cit57","unstructured":"Serotonin noradrenaline reuptake inhibitor (SNRI) medications for the treatment of osteoarthritis pain (STOP) trial"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0058|cit58","unstructured":"Comparison of the efficacy of duloxetine and pregabalin in patients with knee osteoarthritis with mix type pain"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0059|cit59","unstructured":"Evaluating the efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0060|cit60","unstructured":"Duloxetine for chronic osteoarthritis pain; an important alternative?"},{"issue":"10","key":"10.1002\/14651858.CD012157.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.joca.2009.03.021","article-title":"Daily pain variations among patients with hand, hip, and knee osteoarthritis","volume":"17","author":"Allen","year":"2009","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"The American College of Rheumatology Criteria for the classification and reporting of osteoarthritis of the knee","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis & Rheumatism"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/art.1780340502","article-title":"The American College of Rheumatology Criteria for the classification and reporting of osteoarthritis of the hip","volume":"34","author":"Altman","year":"1991","journal-title":"Arthritis & Rheumatism"},{"issue":"20","key":"10.1002\/14651858.CD012157.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1001\/archinte.163.20.2433","article-title":"Depression and pain comorbidity: a literature review","volume":"163","author":"Bair","year":"2003","journal-title":"Archives of Internal Medicine"},{"issue":"11","key":"10.1002\/14651858.CD012157.pub2-BIB0065|cit65","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0066|cit66","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005523.pub2","article-title":"Aquatic exercise for the treatment of knee and hip osteoarthritis","author":"Bartels","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.36076\/ppj.2008\/11\/S105","article-title":"Opioid complications and side effects","volume":"11","author":"Benyamin","year":"2008","journal-title":"Pain Physician"},{"issue":"3","key":"10.1002\/14651858.CD012157.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"A228","DOI":"10.1016\/j.jval.2013.03.1155","article-title":"A European assessment of the impact of inadequate pain relief on health-related quality of life in patients with knee osteoarthritis in the survey of real world therapies","volume":"16","author":"Black","year":"2013","journal-title":"Value in Health"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0069|cit69","unstructured":"Visual Rx www.nntonline.net 2008"},{"issue":"3","key":"10.1002\/14651858.CD012157.pub2-BIB0070|cit70","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005522.pub2","article-title":"Tramadol for osteoarthritis","author":"Cepeda","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD012157.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pain.2009.06.024","article-title":"Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13 week, randomised, placebo-controlled trial","volume":"146","author":"Chappell","year":"2009","journal-title":"Pain"},{"issue":"7","key":"10.1002\/14651858.CD012157.pub2-BIB0072|cit72","doi-asserted-by":"publisher","first-page":"480","DOI":"10.7326\/M16-2458","article-title":"Systemic pharmacologic therapies for low back pain: a systematic review for an American College of Physicians clinical practice guideline","volume":"166","author":"Chou","year":"2017","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/ard.2006.065904","article-title":"Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis","volume":"66","author":"Christensen","year":"2007","journal-title":"Annals of Rheumatic Diseases"},{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3810\/pgm.2012.01.2521","article-title":"A systematic review of duloxetine for osteoarthritic pain: what is the number needed to treat, number needed to harm, and the likelihood to be helped or harmed?","volume":"124","author":"Citrome","year":"2012","journal-title":"Postgraduate Medicine"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Annals of Rheumatic Diseases"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0076|cit76","unstructured":"Deeks JJ Higgins JP Altman DG Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/0091270010394852","article-title":"Efficacy of antidepressants as analgesics: a review","volume":"52","author":"Dharmshaktu","year":"2012","journal-title":"Journal of Clinical Pharmacology"},{"issue":"3","key":"10.1002\/14651858.CD012157.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2007.08.033","article-title":"Pharmacologic management of neuropathic pain: evidence based recommendations","volume":"132","author":"Dworkin","year":"2007","journal-title":"Pain"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpain.2007.09.005","article-title":"Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations","volume":"9","author":"Dworkin","year":"2008","journal-title":"Journal of Pain"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0080|cit80","unstructured":"eTG Complete www.tg.org.au"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/01.bor.0000172800.49120.97","article-title":"The sources of pain in knee osteoarthritis","volume":"17","author":"Felson","year":"2005","journal-title":"Current Opinion in Rheumatology"},{"issue":"8","key":"10.1002\/14651858.CD012157.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1056\/NEJMcp051726","article-title":"Clinical practice. Osteoarthritis of the knee","volume":"354","author":"Felson","year":"2006","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0083|cit83","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007912.pub2","article-title":"Exercise for osteoarthritis of the hip","author":"Fransen","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0084|cit84","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004376.pub3","article-title":"Exercise for osteoarthritis of the knee","author":"Fransen","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0085|cit85","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3899\/jrheum.121306","article-title":"Updated method guidelines for Cochrane musculoskeletal group systematic reviews and metaanalyses","volume":"41","author":"Ghogomu","year":"2014","journal-title":"Journal of Rheumatology"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0086|cit86","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime) 2015"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1001\/jama.2008.944","article-title":"Treatment of fibromyalgia syndrome with antidepressants: a meta analysis","volume":"301","author":"H\u00e4user","year":"2009","journal-title":"JAMA"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0088|cit88","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.joca.2007.12.017","article-title":"Understanding the pain experience in hip and knee osteoarthritis \u2013 an OARSI\/OMERACT initiative","volume":"16","author":"Hawker","year":"2008","journal-title":"Osteoarthritis and Cartilage"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0089|cit89","first-page":"205","article-title":"Knee osteoarthritis prevalence, risk factors, pathogenesis and features: part I","volume":"2","author":"Heidari","year":"2011","journal-title":"Caspian Journal of Internal Medicine"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0090|cit90","unstructured":"Higgins JP Altman DG Sterne JA Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s), Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (updated June 2017). The Cochrane Collaboration, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2\/"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0091|cit91","unstructured":"Higgins JP Li T Deeks JJ Chapter 6: Choosing effect measures and computing estimates of effect. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"issue":"10","key":"10.1002\/14651858.CD012157.pub2-BIB0092|cit92","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005328.pub3","article-title":"Intra-articular corticosteroid for knee osteoarthritis","author":"J\u00fcni","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD012157.pub2-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.sjpain.2011.01.005","article-title":"Understanding the link between depression and pain","volume":"2","author":"Linton","year":"2011","journal-title":"Scandinavian Journal of Pain"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0094|cit94","unstructured":"MIMS Online www.mimsonline.com.au"},{"issue":"10","key":"10.1002\/14651858.CD012157.pub2-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"Journal of Clinical Epidemiology"},{"issue":"9","key":"10.1002\/14651858.CD012157.pub2-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.joca.2013.03.018","article-title":"The epidemiology and impact of pain in osteoarthritis","volume":"21","author":"Neogi","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1002\/14651858.CD012157.pub2-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1517\/14656566.2011.547475","article-title":"Treatment of central sensitisation in patients with 'unexplained' chronic pain: what options do we have?","volume":"12","author":"Nijs","year":"2011","journal-title":"Expert Opinion on Pharmacotherapy"},{"issue":"9","key":"10.1002\/14651858.CD012157.pub2-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1097\/j.pain.0000000000001288","article-title":"Pain sensitization associated with nonresponse after physiotherapy in people with knee osteoarthritis","volume":"159","author":"O'Leary","year":"2018","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0099|cit99","unstructured":"Page MJ Higgins JP Sterne JA Chapter 13: Assessing risk of bias due to missing results in a synthesis. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.joca.2004.02.001","article-title":"OMERACT-OARSI initiative: Osteoarthritis Research Society international set of responder criteria for osteoarthritis clinical trials revisited","volume":"12","author":"Pham","year":"2004","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0101|cit101","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.joca.2004.02.001","article-title":"OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited","volume":"12","author":"Pham","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0102|cit102","unstructured":"Review Manager (RevMan) The Nordic Cochrane Centre, The Cochrane Collaboration 2014"},{"issue":"11","key":"10.1002\/14651858.CD012157.pub2-BIB0103|cit103","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008920.pub2","article-title":"Antidepressants for pain management in rheumatoid arthritis","author":"Richards","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0104|cit104","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002823.pub2","article-title":"Transcutaneous electrostimulation for osteoarthritis of the knee","author":"Rutjes","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0105|cit105","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003132.pub2","article-title":"Therapeutic ultrasound for osteoarthritis of the knee or hip","author":"Rutjes","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0106|cit106","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005454.pub2","article-title":"Antidepressants for neuropathic pain","author":"Saarto","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0107|cit107","unstructured":"Sch\u00fcnemann HJ Vist GE Higgins JP Santesso N Deeks JJ Glasziou P Chapter 15: Interpreting results and drawing conclusions. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0108|cit108","unstructured":"Sch\u00fcnemann HJ Higgins JP Vist GE Glasziou P Akl EA Skoetz N Chapter 14: Completing 'Summary of findings' tables and grading the certainty of the evidence. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/1529-0131(200010)13:5<312::AID-ANR11>3.0.CO;2-L","article-title":"Exploring the priorities of patients with osteoarthritis of the knee","volume":"13","author":"Tallon","year":"2000","journal-title":"Arthritis Care and Research"},{"issue":"6","key":"10.1002\/14651858.CD012157.pub2-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nrrheum.2014.47","article-title":"Osteoarthritis pain: nociceptive or neuropathic?","volume":"10","author":"Thakur","year":"2014","journal-title":"Nature Reviews. Rheumatism"},{"issue":"1","key":"10.1002\/14651858.CD012157.pub2-BIB0111|cit111","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004257.pub2","article-title":"Acetaminophen for osteoarthritis","author":"Towheed","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"10","key":"10.1002\/14651858.CD012157.pub2-BIB0112|cit112","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001703.pub3","article-title":"Antidepressants for non-specific low back pain","author":"Urquhart","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD012157.pub2-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/acr.22224","article-title":"Cost effectiveness of duloxetine for osteoarthritis: a Quebec societal perspective","volume":"66","author":"Wielage","year":"2014","journal-title":"Arthritis Care and Research"},{"issue":"3 Suppl","key":"10.1002\/14651858.CD012157.pub2-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012157.pub2-BIB0116|cit116","doi-asserted-by":"publisher","first-page":"S1063","DOI":"10.1016\/j.joca.2021.03.021","article-title":"Systematic review and meta-analysis of the prevalence of neuropathic-like pain and\/or pain sensitization in people with knee and hip osteoarthritis","volume":"21","author":"Zolio","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1002\/14651858.CD012157.pub2-BIB0117|cit117","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012157","article-title":"Antidepressants for osteoarthritis. Cochrane Database of Systematic Reviews","author":"Lyttle","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T22:07:22Z","timestamp":1761257242000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD012157.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Musculoskeletal Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":117,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd012157.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]}}}