{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:36:27Z","timestamp":1790289387715,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd012389.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000}}],"reference-count":227,"publisher":"Wiley","issue":"4","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd012389.pub3","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T14:16:38Z","timestamp":1586182598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Interventions for preventing silent cerebral infarcts in people with sickle cell disease"],"prefix":"10.1002","volume":"2020","author":[{"given":"Lise J","family":"Estcourt","sequence":"first","affiliation":[{"name":"NHS Blood and Transplant; Haematology\/Transfusion Medicine; Level 2, John Radcliffe Hospital Headington Oxford UK OX3 9BQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Kimber","sequence":"additional","affiliation":[{"name":"Systematic Review Initiative, NHS Blood and Transplant; Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Hopewell","sequence":"additional","affiliation":[{"name":"University of Oxford; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS); Botnar Research Centre, Windmill Road Oxford Oxfordshire UK OX3 7LD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialena","family":"Trivella","sequence":"additional","affiliation":[{"name":"University of Oxford; Centre for Statistics in Medicine; Botnar Research Centre Windmill Road Oxford UK OX3 7LD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Doree","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant; Systematic Review Initiative; John Radcliffe Hospital Oxford UK OX3 9BQ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel R","family":"Abboud","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center; Department of Pediatrics and Adolescent Medicine; Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ajh.23877","article-title":"Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy","volume":"90","author":"Beverung","year":"2015","journal-title":"American Journal of Hematology"},{"issue":"22","key":"10.1002\/14651858.CD012389.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1182\/blood.V114.22.2563.2563","article-title":"Genome-wide association for silent cerebral infarction (SCI) in sickle cell disease: the silent infarct transfusion trial (SIT) cohort","volume":"114","author":"Bhatnagar","year":"2009","journal-title":"Blood"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/jhg.2011.12","article-title":"Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients","volume":"56","author":"Bhatnagar","year":"2011","journal-title":"Journal of Human Genetics"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"316-23. Supplem","DOI":"10.1038\/jhg.2011.12","article-title":"Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients","volume":"56","author":"Bhatnagar","year":"2011","journal-title":"Journal of Human Genetics"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/08880010903360367","article-title":"Design of the silent cerebral infarct transfusion (SIT) trial","volume":"27","author":"Casella","year":"2010","journal-title":"Pediatric Hematology & Oncology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0006|cit6","doi-asserted-by":"crossref","unstructured":"Choudhury NA DeBaun MR Ponisio MR Jordan LC Rodeghier M Pruthi S Intracranial vasculopathy and infarct recurrence in children with sickle cell anaemia, silent cerebral infarcts and normal transcranial Doppler velocities British Journal of Haematology 2018 324 6","DOI":"10.1111\/bjh.14979"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1212\/WNL.0000000000004832","article-title":"Silent cerebral infarct definitions and full-scale IQ loss in children with sickle cell anemia","volume":"90","author":"Choudhury","year":"2018","journal-title":"Neurology"},{"issue":"12","key":"10.1002\/14651858.CD012389.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"E406","DOI":"10.1002\/ajh.25297","article-title":"Progressive loss of brain volume in children with sickle cell anemia and silent cerebral infarct: A report from the silent cerebral infarct transfusion trial","volume":"93","author":"Darbari","year":"2018","journal-title":"American Journal of Hematology"},{"issue":"8","key":"10.1002\/14651858.CD012389.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1401731","article-title":"Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia","volume":"371","author":"DeBaun","year":"2014","journal-title":"New England Journal of Medicine"},{"issue":"16","key":"10.1002\/14651858.CD012389.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1182\/blood-2011-05-349621","article-title":"Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure","volume":"119","author":"DeBaun","year":"2012","journal-title":"Blood"},{"issue":"23","key":"10.1002\/14651858.CD012389.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1182\/blood.V126.23.546.546","article-title":"Progressive loss of brain volume in children with sickle cell anemia: a report from the silent cerebral infarct transfusion trial cohort","volume":"126","author":"Eigbire-Molen","year":"2015","journal-title":"Blood"},{"issue":"22","key":"10.1002\/14651858.CD012389.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1182\/blood.V128.22.3655.3655","article-title":"Cost-effectiveness of blood transfusions versus observation for silent cerebral infarcts from the silent cerebral infarct trial","volume":"128","author":"Gay","year":"2016","journal-title":"Blood"},{"issue":"6","key":"10.1002\/14651858.CD012389.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1553-2712.2012.01364.x","article-title":"Risk factors for increased ED utilization in a multinational cohort of children with sickle cell disease","volume":"19","author":"Glassberg","year":"2012","journal-title":"Academic Emergency Medicine"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0014|cit14","unstructured":"ISRCTN52713285 Silent Cerebral Infarct Multi-Center Clinical Trial www.isrctn.com\/ISRCTN52713285"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/bjh.14039","article-title":"Brain atrophy in paediatric sickle cell anaemia: findings from the silent infarct transfusion (SIT) trial","volume":"177","author":"Kawadler","year":"2017","journal-title":"British Journal of Haematology"},{"issue":"10","key":"10.1002\/14651858.CD012389.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/ajh.23805","article-title":"Silent cerebral infarction, income, and grade retention among students with sickle cell anemia","volume":"89","author":"King","year":"2014","journal-title":"American Journal of Hematology"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ajh.23604","article-title":"Parent education and biologic factors influence on cognition in sickle cell anemia","volume":"89","author":"King","year":"2014","journal-title":"American Journal of Hematology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/S1090-3798(11)70202-1","article-title":"Brain T2-weighted signal intensity ratio in children with sickle cell disease with and without stroke","volume":"15 Suppl 1","author":"Kirkham","year":"2011","journal-title":"European Journal of Paediatric Neurology"},{"issue":"19","key":"10.1002\/14651858.CD012389.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1056\/NEJMc1411133","article-title":"Transfusions for silent cerebral infarcts in sickle cell anemia","volume":"371","author":"Land","year":"2014","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD012389.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1177\/0883073813506491","article-title":"Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia","volume":"29","author":"Liem","year":"2014","journal-title":"Journal of Child Neurology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0021|cit21","unstructured":"NCT00072761 Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial (SIT) clinicaltrials.gov\/show\/NCT00072761"},{"issue":"23","key":"10.1002\/14651858.CD012389.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1182\/blood.V126.23.3410.3410","article-title":"Parvovirus B19 infection associated with silent cerebral infarcts: a secondary analysis of the silent cerebral infarct trial cohort","volume":"126","author":"Ogunsile","year":"2015","journal-title":"Blood"},{"issue":"21","key":"10.1002\/14651858.CD012389.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1182\/blood.V116.21.268.268","article-title":"Acute silent cerebral ischemia occurs more frequently than silent cerebral infarction in children with sickle cell anemia","volume":"116","author":"Quinn","year":"2010","journal-title":"Blood"},{"issue":"9","key":"10.1002\/14651858.CD012389.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/pbc.25072","article-title":"Randomization is not associated with socio-economic and demographic factors in a multi-center clinical trial of children with sickle cell anemia","volume":"61","author":"Roberts","year":"2014","journal-title":"Pediatric Blood & Cancer"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/bjh.12034","article-title":"Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia","volume":"159","author":"Thangarajh","year":"2012","journal-title":"British Journal of Haematology"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s10278-008-9114-3","article-title":"Silent cerebral infarct transfusion (SIT) trial imaging core: application of novel imaging information technology for rapid and central review of MRI of the brain","volume":"22","author":"Vendt","year":"2009","journal-title":"Journal of Digital Imaging"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ajh.23854","article-title":"Factors associated with growth and blood pressure patterns in children with sickle cell anemia: Silent Cerebral Infarct Multi-Center Clinical Trial cohort","volume":"90","author":"Wolf","year":"2015","journal-title":"American Journal of Hematology"},{"issue":"19","key":"10.1002\/14651858.CD012389.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1056\/NEJMc1411133","article-title":"Transfusions for silent cerebral infarcts in sickle cell anemia","volume":"371","author":"Land","year":"2014","journal-title":"New England Journal of Medicine"},{"issue":"10 Suppl 1","key":"10.1002\/14651858.CD012389.pub3-BIB0029|cit29","first-page":"645a","article-title":"Magnetic resonance angiography (MRA) in children with abnormal transcranial doppler (TCD) velocities in the 'STOP' study","volume":"94","author":"Abboud","year":"1999","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0030|cit30","unstructured":"Abboud MR Cure J Gallagher D Berman B Hsu L Wang W Magnetic resonance angiography in children with abnormal TCD in the STOP study National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 1999 Mar; 1999 49"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0031|cit31","unstructured":"Adamkiewicz T Abboud M Barredo J Cavalier ME Peterson J Rackoff B Serum ferritin in children with SCD on chronic transfusion: correlation with serum alanine aminotransferase and liver iron (STOP\/STOP II liver iron ancillary study) 35th Anniversary Convention of the National Sickle Cell Disease Program and the Sickle Cell Disease Association of America; 2007 Sep 17-22; Washington DC 2007 316"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0032|cit32","doi-asserted-by":"crossref","unstructured":"Adamkiewicz T Abboud MR Barredo JC Kirby-Allen M Alvarez OA Casella JF Serum ferritin in children with sickle cell disease on chronic transfusion: measure of iron overload or end organ injury? STOP\/ STOP II liver iron ancillary study Blood 2006","DOI":"10.1182\/blood.V108.11.791.791"},{"issue":"11 Pt 1","key":"10.1002\/14651858.CD012389.pub3-BIB0033|cit33","first-page":"10a","article-title":"Stroke prevention in sickle cell disease (STOP): final results","volume":"96","author":"Adams","year":"2000","journal-title":"Blood"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0034|cit34","first-page":"308","article-title":"Stroke prevention in sickle cell disease (STOP): Results of transcranial doppler ultrasound screening stroke risk","volume":"29","author":"Adams","year":"1998","journal-title":"Stroke; a Journal of Cerebral Circulation"},{"issue":"5","key":"10.1002\/14651858.CD012389.pub3-BIB0046|cit35","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/088307380001500511","article-title":"Lessons from the stroke prevention trial in sickle cell anemia (STOP) study","volume":"15","author":"Adams","year":"2000","journal-title":"Journal of Child Neurology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0040|cit36","doi-asserted-by":"crossref","unstructured":"Adams RJ Brambilla D Stroke prevention in sickle cell anaemia: the 'STOP' trial 22nd International Joint Conference on Stroke and Cerebral cCrculation; 1997 Feb 6-8; Anaheim, California 1997","DOI":"10.1007\/BF03271356"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0041|cit37","unstructured":"Adams RJ Brambilla D Stroke prevention trial in sickle cell anemia: STOP National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 1996 Mar 1996 19"},{"issue":"10 Suppl 1","key":"10.1002\/14651858.CD012389.pub3-BIB0035|cit38","first-page":"419a","article-title":"Risk of stroke in children with sickle cell disease and abnormal transcranial doppler ultrasound (TCD)","volume":"94","author":"Adams","year":"1999","journal-title":"Blood"},{"issue":"10 Suppl 1","key":"10.1002\/14651858.CD012389.pub3-BIB0036|cit39","first-page":"527a","article-title":"Stroke prevention in sickle cell disease (STOP): follow up after closure of the trial","volume":"92","author":"Adams","year":"1998","journal-title":"Blood"},{"issue":"10 Suppl 1","key":"10.1002\/14651858.CD012389.pub3-BIB0037|cit40","first-page":"123a","article-title":"Stroke prevention in sickle cell disease (STOP): baseline characteristics of trial patients","volume":"90","author":"Adams","year":"1997","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0038|cit41","unstructured":"Adams RJ Brambilla D Miller ST Optimizing primary stroke prevention in children with sickle cell 28th Annual Meeting of the National Sickle Cell Disease Program; 2005 April 9-13; Cincinnati, Ohio. 2005 3"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0039|cit42","unstructured":"Adams RJ Brambilla D Vichinsky E Abboud M Pegelow C Carl EM Risk of stroke and conversion to abnormal TCD in children screened with transcranial doppler (TCD) during the STOP study National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 2002 Sept 2002 3"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0042|cit43","unstructured":"Adams RJ Brambilla DJ McKie V File B Vichinsky E Abboud M Stroke prevention in sickle cell disease (STOP): Baseline characteristics of trial patients National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 1997 Sept 1997 41"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0043|cit44","unstructured":"Adams RJ Brambilla DJ STOP II Investigators The study design of optimizing primary stroke prevention in children with sickle cell anemia 27th Annual Meeting of the National Sickle Cell Disease Program; 2004 Apr 18-21; Los Angeles, California 2004 174"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0044|cit45","unstructured":"Adams RJ Brambilla DJ Vichinsky E Abboud M Pegelow C Carl EM Stroke prevention trial in sickle cell anemia (STOP Study): risk of stroke in 1933 children screened with transcranial doppler (TCD) National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 1999 Mar 1999 54"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0045|cit46","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0197-2456(97)00099-8","article-title":"Stroke prevention trial in sickle cell anemia","volume":"19","author":"Adams","year":"1998","journal-title":"Controlled Clinical Trials"},{"issue":"10 Suppl 1","key":"10.1002\/14651858.CD012389.pub3-BIB0047|cit47","first-page":"528a","article-title":"A randomized trial of chronic transfusion to prevent stroke in sickle cell anemia: changes in ferritin with chronic transfusion","volume":"92","author":"Files","year":"1998","journal-title":"Blood"},{"issue":"5","key":"10.1002\/14651858.CD012389.pub3-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1067\/mpd.2002.128754","article-title":"Stroke prevention trial in sickle cell anemia: comments on effects of chronic transfusion on pain","volume":"141","author":"Gates","year":"2002","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0049|cit49","doi-asserted-by":"crossref","unstructured":"Hyacinth HI Gee BE Voeks JH Adams RJ Hibbert J High frequency of RBC transfusions in the STOP study was associated with reduction in serum biomarkers of neurodegeneration, vascular remodeling and inflammation Blood 2012","DOI":"10.1182\/blood.V120.21.244.244"},{"issue":"11 Pt 2","key":"10.1002\/14651858.CD012389.pub3-BIB0050|cit50","first-page":"18b","article-title":"Laboratory parameters in patients randomized in the STOP study and their modification by transfusion","volume":"96","author":"Kutlar","year":"2000","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0051|cit51","unstructured":"Kutlar A Harbin J Jackson BB Holley LGD Clair B Brambilla D Baseline laboratory parameters in patients randomized to the STOP study and their modification by transfusion National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 2000 Apr 2000 82a"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2141.2006.06193.x","article-title":"Elevated blood flow velocity in the anterior cerebral artery and stroke risk in sickle cell disease: extended analysis from the STOP trial","volume":"134","author":"Kwiatkowski","year":"2006","journal-title":"British Journal of Haematology"},{"issue":"11 Pt 1","key":"10.1002\/14651858.CD012389.pub3-BIB0053|cit53","first-page":"663a","article-title":"Long-term follow-up of transcranial doppler ultrasonography in children with sickle cell disease: Results of the STOP and STOP II patient cohorts","volume":"100","author":"Kwiatkowski","year":"2002","journal-title":"Blood"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1182\/blood-2005-10-009506","article-title":"Stroke prevention trial in sickle cell anemia (STOP): extended follow-up and final results","volume":"108","author":"Lee","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0055|cit55","first-page":"373","article-title":"C-reactive protein in children with sickle cell disease at risk for stroke in the STOP study","volume":"33","author":"Lee","year":"2002","journal-title":"Stroke; a Journal of Cerebral Circulation"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0056|cit56","first-page":"695","article-title":"Transfusion lowers plasma-free hemoglobin in children with sickle cell disease at risk for stroke","volume":"37","author":"Lezcano","year":"2006","journal-title":"Stroke; a Journal of Cerebral Circulation"},{"issue":"4 Pt 2","key":"10.1002\/14651858.CD012389.pub3-BIB0057|cit57","first-page":"251A","article-title":"Impact of chronic transfusion on non-neurological events during the stroke prevention trial in sickle cell anemia (STOP)","volume":"47","author":"Miller","year":"2000","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0058|cit58","unstructured":"Miller S Wright E Abboud M Berman B Files B Scher C Impact of chronic transfusion on non-neurological events during the stroke prevention trial in sickle cell anemia (STOP) National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 2000 Apr 2000 61a"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0059|cit59","unstructured":"NCT00000592 Stroke Prevention in Sickle Cell Anemia (STOP 1) clinicaltrials.gov\/ct2\/show\/NCT00000592"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0060|cit60","unstructured":"National Heart Lung Blood Institute (NHLBI) Clinical alert: periodic transfusions lower stroke risk in children with sickle cell anemia https:\/\/www.nlm.nih.gov\/databases\/alerts\/sickle97.html www.nlm.nih.gov\/databases\/alerts\/sickle97.html"},{"issue":"11 Pt 1","key":"10.1002\/14651858.CD012389.pub3-BIB0061|cit61","first-page":"486a","article-title":"Changes in cerebral blood flow velocities during chronic transfusion therapy to prevent stroke in sickle cell disease","volume":"96","author":"Olivieri","year":"2000","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0062|cit62","unstructured":"Pegelow C Adams R Hsu L McKie V Wang W Zimmerman R Children with silent infarct and elevated transcranial doppler ultrasonography velocity are at increased risk of subsequent infarctive events National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 1999 Mar 1999 137"},{"issue":"12","key":"10.1002\/14651858.CD012389.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1001\/archneur.58.12.2017","article-title":"Silent infarcts in children with sickle cell anemia and abnormal cerebral artery velocity","volume":"58","author":"Pegelow","year":"2001","journal-title":"Archives of Neurology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1056\/NEJM199811123392013","article-title":"Prevention of stroke by transfusions in children with sickle cell anemia","volume":"339","author":"Sarnaik","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0065|cit65","unstructured":"Vichinsky E Luban E Wright E Olivieri N Driscoll C Pegelow Prospective red cell phenotype matching in STOP - a multi-centre transfusion trial National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 1999 Mar 1999 163"},{"issue":"10 Suppl 1","key":"10.1002\/14651858.CD012389.pub3-BIB0066|cit66","first-page":"528a","article-title":"Prospective red cell phenotype matching in STOP - a multi-center transfusion trial","volume":"92","author":"Vichinsky","year":"1998","journal-title":"Blood"},{"issue":"9","key":"10.1002\/14651858.CD012389.pub3-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1046\/j.1537-2995.2001.41091086.x","article-title":"Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial","volume":"41","author":"Vichinsky","year":"2001","journal-title":"Transfusion"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0068|cit68","unstructured":"Wang W Morales K Olivier N Styles L Scher C Adams R Effect of chronic transfusion on growth in children with sickle cell anemia: results of the STOP trial National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 2002 Sept 2002 100"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0069|cit69","doi-asserted-by":"crossref","unstructured":"Abboud MR Yim E Adams RJ The progression and development of silent infarcts in children with sickle cell anemia is prevented by chronic transfusions and is unrelated to level of hemolysis Blood 2008","DOI":"10.1182\/blood.V112.11.712.712"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1182\/blood-2010-12-326298","article-title":"Discontinuing prophylactic transfusions increases the risk of silent brain infarction in children with sickle cell disease: data from STOP II","volume":"118","author":"Abboud","year":"2011","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0071|cit71","unstructured":"Adamkiewicz T Transcranial doppler measures in patients with sickle cell disease at high risk for stroke and receiving hydroxyurea: the HyRetro ancillary study 52nd Ash Annual Meeting and Exposition; 2010 Dec 4-7; Orlando, Florida 2010"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0072|cit72","doi-asserted-by":"crossref","unstructured":"Adams R Fullerton H Kwiatkowski Voeks J Development of high risk TCD in sickle cell disease Stroke; a Journal of Cerebral Circulation 2015","DOI":"10.1161\/str.46.suppl_1.17"},{"issue":"26","key":"10.1002\/14651858.CD012389.pub3-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1056\/NEJMoa050460","article-title":"Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease","volume":"353","author":"Adams","year":"2005","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD012389.pub3-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/ajh.24551","article-title":"Transcranial doppler re-screening of subjects who participated in STOP and STOP II","volume":"91","author":"Adams","year":"2016","journal-title":"American Journal of Hematology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0075|cit75","unstructured":"Brown C Miller S Kwiatkowski J Brambilla D Adams R Optimizing primary stroke prevention in sickle cell anemia (STOP 2): an argument for prolonged transfusion? 29th Annual Meeting of the National Sickle Cell Disease Program; 2006 Apr 8-12; Memphis, USA. 2006 78"},{"issue":"23","key":"10.1002\/14651858.CD012389.pub3-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1182\/blood.V126.23.3402.3402","article-title":"Impact of TCD screening protocol on the incidence of hemorrhagic stroke in children and young adults with sickle cell disease","volume":"126","author":"Kanter","year":"2015","journal-title":"Blood"},{"issue":"23","key":"10.1002\/14651858.CD012389.pub3-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1182\/blood.V126.23.68.68","article-title":"Ischemic stroke in children and young adults with sickle cell disease (SCD) in the post-STOP era","volume":"126","author":"Kwiatkowski","year":"2015","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0078|cit78","unstructured":"NCT00006182 Stroke prevention in sickle cell anemia (STOP 2) clinicaltrials.gov\/show\/NCT00006182"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0079|cit79","doi-asserted-by":"crossref","unstructured":"Sayer G Bowman L Clair B Cail A Blanchard B Natrajan K Long term outcome of patients enrolled into STOP and STOP II trials: a single center experience Blood 2012","DOI":"10.1182\/blood.V120.21.3219.3219"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/bjh.13280","article-title":"Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload","volume":"169","author":"Aygun","year":"2015","journal-title":"British Journal of Haematology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0081|cit81","unstructured":"Aygun B Mortier NA Kesler K Schultz WH Alvarez OA Rogers ZR Therapeutic phlebotomy in children with sickle cell anemia, stroke, and iron overload: the SWiTCH experience 53rd Ash Annual Meeting and Exposition; 2011 Dec 10-13; San Diego, California. 2011"},{"issue":"6","key":"10.1002\/14651858.CD012389.pub3-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1182\/blood-2013-12-545186","article-title":"Magnetic resonance imaging\/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial","volume":"124","author":"Helton","year":"2014","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0083|cit83","unstructured":"NCT00122980 Stroke with transfusions changing to hydroxyurea (SWiTCH) clinicaltrials.gov\/ct2\/show\/NCT00122980"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0084|cit84","unstructured":"National Institutes of Health Stroke prevention study in children with sickle cell anemia, iron overload stopped early www.nih.gov\/news\/health\/jun2010\/nhlbi-03.htm"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0086|cit85","doi-asserted-by":"crossref","unstructured":"Ware RE Helms RW Stroke with transfusions changing to hydroxyurea (SWiTCH): a phase 3 randomised clinical trial for treatment of children with sickle cell anemia American Journal of Hematology 2011","DOI":"10.1182\/blood.V116.21.844.844"},{"issue":"21","key":"10.1002\/14651858.CD012389.pub3-BIB0087|cit86","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1182\/blood.V116.21.844.844","article-title":"Stroke with transfusions changing to hydroxyurea (SWiTCH): a phase 3 randomized clinical trial for treatment of children with sickle cell anemia, previous stroke, and iron overload","volume":"116","author":"Ware","year":"2010","journal-title":"Blood"},{"issue":"17","key":"10.1002\/14651858.CD012389.pub3-BIB0085|cit87","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1182\/blood-2011-11-392340","article-title":"Stroke with transfusions changing to hydroxyurea (SWiTCH)","volume":"119","author":"Ware","year":"2012","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0088|cit88","doi-asserted-by":"crossref","unstructured":"Ware RE McMurray MA Schultz WH Alvarez OA Aygun B Cavalier ME Academic community standards for chronic transfusion therapy in children with sickle cell anemia and stroke Blood 2006","DOI":"10.1182\/blood.V108.11.1213.1213"},{"issue":"6","key":"10.1002\/14651858.CD012389.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/pbc.23145","article-title":"Stroke with transfusions changing to hydroxyurea (SWiTCH): a phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload","volume":"57","author":"Ware","year":"2011","journal-title":"Pediatric Blood & Cancer"},{"issue":"22","key":"10.1002\/14651858.CD012389.pub3-BIB0090|cit90","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1182\/blood.V128.22.1018.1018","article-title":"Iron unloading by therapeutic phlebotomy in previously transfused children with sickle cell anemia: the twitch experience","volume":"128","author":"Aygun","year":"2016","journal-title":"Blood"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/ajh.23105","article-title":"Chronic transfusion practices for prevention of primary stroke in children with sickle cell anemia and abnormal TCD velocities","volume":"87","author":"Aygun","year":"2012","journal-title":"American Journal of Hematology"},{"issue":"21","key":"10.1002\/14651858.CD012389.pub3-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1182\/blood.V124.21.4052.4052","article-title":"Effects of Chronic Transfusion Therapy on MRI and MRA in Children with Sickle Cell Anemia at Risk for Primary Stroke: Baseline Imaging from theTwitch Trial","volume":"124","author":"Helton","year":"2014","journal-title":"Blood"},{"issue":"21","key":"10.1002\/14651858.CD012389.pub3-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1182\/blood.V124.21.87.87","article-title":"Effects of chronic transfusion therapy on transcranial doppler ultrasonography velocities in children with sickle cell anemia at risk for primary stroke: Baseline findings from the Twitch trial","volume":"124","author":"Imran","year":"2014","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0094|cit94","unstructured":"NCT01425307 Transcranial doppler (TCD) with transfusions changing to hydroxyurea clinicaltrials.gov\/ct2\/show\/NCT01425307"},{"issue":"23","key":"10.1002\/14651858.CD012389.pub3-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood.V126.23.3.3","article-title":"TCD with transfusions changing to hydroxyurea (TWiTCH): hydroxyurea therapy as an alternative to transfusions for primary stroke prevention in children with sickle cell anemia","volume":"126","author":"Ware","year":"2015","journal-title":"Blood"},{"issue":"10019","key":"10.1002\/14651858.CD012389.pub3-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0140-6736(15)01041-7","article-title":"Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia - TCD with Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial","volume":"387","author":"Ware","year":"2016","journal-title":"Lancet"},{"issue":"22","key":"10.1002\/14651858.CD012389.pub3-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1182\/blood.V128.22.1019.1019","article-title":"Variation in serial TCD velocity measurements in the tcd with transfusions changing to hydroxyurea (TWiTCH) trial","volume":"128","author":"Ware","year":"2016","journal-title":"Blood"},{"issue":"21","key":"10.1002\/14651858.CD012389.pub3-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1182\/blood.V122.21.2238.2238","article-title":"Extrahepatic iron deposition in chronically transfused children with sickle cell anemia- baseline findings from the Twitch trial","volume":"122","author":"Wood","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/bjh.13791","article-title":"Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial.","volume":"172","author":"Wood","year":"2016","journal-title":"British Journal of Haematology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0100|cit100","doi-asserted-by":"crossref","unstructured":"Wood JC Ofelia A Heeney MM George A Gauger C Fuh B Changes in extrahepatic iron load in response to iron chelation versus phlebotomy: observations from the twitch trial Blood 2016 202","DOI":"10.1182\/blood.V128.22.202.202"},{"issue":"9","key":"10.1002\/14651858.CD012389.pub3-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/ajh.24089","article-title":"Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: baseline results from the TWiTCH trial.","volume":"90","author":"Wood","year":"2015","journal-title":"American Journal of Hematology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0102|cit102","doi-asserted-by":"crossref","unstructured":"Wood JC St Pierre T Aygun B Mortier N Schultz WH Piccone CM Agreement between R2 and R2* liver iron estimates is independent of the type of iron removal therapy: results from the twitch trial Blood 2016","DOI":"10.1182\/blood.V128.22.1274.1274"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0103|cit103","unstructured":"Adams RJ Carl EM McKie VC Odo NA Kutlar A Phillips M Brambilla D A pilot trial of hydroxyurea to prevent strokes in children with sickle cell anemia National Sickle Cell Disease Program Annual Meeting Conference Proceedings; 1999 Mar 1999 53"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0104|cit104","unstructured":"Adams RJ Luden J Miller S Wang W Rees R Li D TCD in infants: a report from the Baby Hug study 28th Annual Meeting of the National Sickle Cell Disease Program; 2005 Apr 9-13; Cincinnati, Ohio. 2005 105"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/pbc.24100","article-title":"Effect of hydroxyurea treatment on renal function parameters: results from the multi-center placebo-controlled BABY HUG clinical trial for infants with sickle cell anemia","volume":"59","author":"Alvarez","year":"2012","journal-title":"Pediatric Blood & Cancer"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1542\/peds.2012-0283","article-title":"Developmental function in toddlers with sickle cell anemia","volume":"131","author":"Armstrong","year":"2013","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0107|cit107","unstructured":"Casella JF Wang WC Rogers ZR Rees RC Iyer RV Rana S Progress of the Multicenter Trial of Hydroxyurea in Infants with Sickle Cell Anemia (BABY HUG) and Assessment of Baseline Splenic and Renal Function Pediatric Academic Societies Annual Meeting; 2005 May 14-17; Washington DC, United States 2005 1111"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clinbiochem.2012.10.032","article-title":"Comparison of hematologic measurements between local and central laboratories: data from the BABY HUG trial","volume":"46","author":"Kalpatthi","year":"2013","journal-title":"Clinical Biochemistry"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0109|cit109","doi-asserted-by":"crossref","unstructured":"Lebensburger JD Miller ST Howard TH Casella JF Brown RC Lu M Influence of hemoglobin level on clinical findings in infants with sickle cell anemia; data from BABY HUG Blood American Society of Hematology 2010 1631","DOI":"10.1182\/blood.V116.21.1631.1631"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/pbc.24037","article-title":"Influence of severity of anemia on clinical findings in infants with sickle cell anemia: analyses from the BABY HUG study","volume":"59","author":"Lebensburger","year":"2012","journal-title":"Pediatric Blood & Cancer"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0111|cit111","doi-asserted-by":"crossref","unstructured":"Lederman HM Connolly MA Ware RE Luchtman-Jones L Goldsmith JC Effects of hydroxyurea (HU) on lymphocyte subsets and the immune response to pneumococcal, measles, mumps and rubella vaccination in the pediatric hydroxyurea phase III clinical trial - BABY HUG Blood 2012","DOI":"10.1182\/blood.V120.21.243.243"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/pbc.23365","article-title":"Genotoxicity associated with hydroxyurea exposure in infants with sickle cell anemia: results from the BABY-HUG Phase III Clinical Trial","volume":"59","author":"McGann","year":"2012","journal-title":"Pediatric Blood & Cancer"},{"issue":"7","key":"10.1002\/14651858.CD012389.pub3-BIB0113|cit113","first-page":"1015","article-title":"Genetic modifiers of sickle cell anemia in the baby hug cohort","volume":"58","author":"Sheehan","year":"2012","journal-title":"Pediatric Blood & Cancer"},{"issue":"7","key":"10.1002\/14651858.CD012389.pub3-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/ajh.23457","article-title":"Genetic modifiers of sickle cell anemia in the BABY HUG cohort: influence on laboratory and clinical phenotypes","volume":"88","author":"Sheehan","year":"2013","journal-title":"American Journal of Hematology"},{"issue":"22","key":"10.1002\/14651858.CD012389.pub3-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"4304-10; quiz 4","DOI":"10.1182\/blood-2012-03-419879","article-title":"Impact of hydroxyurea on clinical events in the BABY HUG trial","volume":"120","author":"Thornburg","year":"2012","journal-title":"Blood"},{"issue":"7","key":"10.1002\/14651858.CD012389.pub3-BIB0116|cit116","first-page":"E20","article-title":"Effects of hydroxyurea in asymptomatic infants with sickle cell anemia: Analysis F from the BABY HUG trial","volume":"87","author":"Wang","year":"2012","journal-title":"American Journal of Hematology"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"67783","DOI":"10.1542\/peds.2013-0333","article-title":"Hydroxyurea is associated with lower costs of care of young children with sickle cell anemia","volume":"132","author":"Wang","year":"2013","journal-title":"Pediatrics"},{"issue":"5","key":"10.1002\/14651858.CD012389.pub3-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/pbc.21612","article-title":"MRI abnormalities of the brain in one-year-old children with sickle cell anemia","volume":"51","author":"Wang","year":"2008","journal-title":"Pediatric Blood & Cancer"},{"issue":"9778","key":"10.1002\/14651858.CD012389.pub3-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0140-6736(11)60355-3","article-title":"Hydroxycarbamide in very young children with sickle cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)","volume":"377","author":"Wang","year":"2011","journal-title":"Lancet"},{"issue":"Supplement 1","key":"10.1002\/14651858.CD012389.pub3-BIB0120|cit120","first-page":"617","article-title":"Health-related quality of life at 1 year in the drepagreffe trial comparing chronic transfusion to transplantation in children with sickle cell anemia and a history of abnormal cerebral velocities","volume":"130","author":"Bernaudin","year":"2017","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0121|cit121","first-page":"S49","article-title":"Trial comparing HSCT vs transfusions in sickle cell anemia (SCA) patients with abnormal cerebral velocities: cerebral vasculopathy outcome at 1 year","volume":"51","author":"Bernaudin","year":"2016","journal-title":"Bone Marrow Transplantation"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0122|cit122","doi-asserted-by":"crossref","unstructured":"Bernaudin F Verlhac S Ducros-Miralles E Delatour RP Dalle JH Petra E French national Drepagreffe trial: cognitive performances and neuroimaging at enrollment and after 12 months on transfusion program or transplantation (AP-HP: NCT 01340404) Blood 2015 544","DOI":"10.1182\/blood.V126.23.544.544"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1001\/jama.2018.20059","article-title":"Association of matched sibling donor hematopoietic stem cell transplantation with transcranial doppler velocities in children with sickle cell anemia","volume":"321","author":"Bernaudin","year":"2019","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cct.2017.08.008","article-title":"Design of the DREPAGREFFE trial: A prospective controlled multicenter study evaluating the benefit of genoidentical hematopoietic stem cell transplantation over chronic transfusion in sickle cell anemia children detected to be at risk of stroke by transcranial Doppler (NCT 01340404)","volume":"62","author":"Chevret","year":"2017","journal-title":"Contemporary Clinical Trials"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0125|cit125","unstructured":"NCT01340404 Allogeneic genoidentical stem cell transplantation in children with sickle-cell anemia and cerebral vasculopathy clinicaltrials.gov\/ct2\/show\/NCT01340404"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13063-017-2419-0","article-title":"Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial","volume":"19","author":"Howard","year":"2018","journal-title":"Trials"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0127|cit127","unstructured":"ISRCTN46012373 Improvement of pain and quality of life in patients with sickle cell disease with auto-adjusting continuous positive airways pressure therapy www.isrctn.com\/ISRCTN46012373"},{"issue":"Supplement 1","key":"10.1002\/14651858.CD012389.pub3-BIB0128|cit128","first-page":"A41","article-title":"Feasibility and safety of and adherence to auto-adjusting continuous positive airways pressure for 6 months in sickle cell anaemia","volume":"102","author":"Inusa","year":"2017","journal-title":"Archives of Disease in Childhood"},{"issue":"Supplement 1","key":"10.1002\/14651858.CD012389.pub3-BIB0129|cit129","first-page":"3537","article-title":"Prevention of morbidity in sickle cell disease phase II (improvement of pain and quality of life in children with sickle cell disease with auto-adjusting continuous positive airways pressure: Phase II) (poms 2B pediatric cohort)","volume":"130","author":"Inusa","year":"2017","journal-title":"Blood"},{"issue":"Supplement 1","key":"10.1002\/14651858.CD012389.pub3-BIB0130|cit130","first-page":"31","article-title":"Prevention of morbidity in sickle cell disease phase 2 (poms 2B pediatric): Improvement of cognition in children with sickle cell disease with auto-adjusting continuous positive airways pressure: A single-blind, randomized, controlled phase II trial","volume":"181","author":"Slee","year":"2018","journal-title":"British Journal of Haematology"},{"issue":"Supplement 1","key":"10.1002\/14651858.CD012389.pub3-BIB0131|cit131","first-page":"3556","article-title":"Prevention of morbidity in sickle cell disease phase II (improvement of cognition in children with sickle cell disease with auto-adjusting continuous positive airways pressure: Phase II) (poms 2B paediatric cohort)","volume":"130","author":"Slee","year":"2017","journal-title":"Blood"},{"issue":"7","key":"10.1002\/14651858.CD012389.pub3-BIB0132|cit132","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/dmcn.13113","article-title":"Intelligence quotient in paediatric sickle cell disease: a systematic review and meta-analysis","volume":"58","author":"Kawadler","year":"2016","journal-title":"Developmental Medicine & Child Neurology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0133|cit133","first-page":"167","article-title":"Results of transcranial doppler ultrasound screening from the post-stop study","volume":"Supplement 1","author":"Kanter","year":"2016","journal-title":"Haematologica"},{"issue":"12","key":"10.1002\/14651858.CD012389.pub3-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/ajh.25635","article-title":"Ischemic stroke in children and young adults with sickle cell disease in the post-STOP era","volume":"94","author":"Kwiatkowski","year":"2019","journal-title":"American Journal of Hematology"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/ebm.2011.100104","article-title":"Hydroxycarbamide for very young children with sickle cell anaemia: No effect on the primary outcomes of spleen or kidney function, but evidence for decreased pain and dactylitis, with minimal toxicity","volume":"17","author":"Manwani","year":"2012","journal-title":"Evidence-Based Medicine"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bjhh.2016.08.004","article-title":"A Phase Ib open label, randomized, safety study of SANGUINATETM in patients with sickle cell anemia","volume":"39","author":"Misra","year":"2017","journal-title":"Revista Brasileira de Hematologia e Hemoterapia"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0137|cit137","unstructured":"NCT00004485 Bone marrow transplantation in treating children with sickle cell disease clinicaltrials.gov\/ct2\/show\/NCT00004485"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0138|cit138","unstructured":"NCT00402480 Hydroxyurea to prevent stroke in children with sickle cell anemia and elevated TCD flow velocity clinicaltrials.gov\/ct2\/show\/NCT00402480"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0139|cit139","unstructured":"NCT01801423 Sickle cell disease - stroke prevention in Nigeria trial (SPIN) clinicaltrials.gov\/ct2\/show\/NCT01801423"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0140|cit140","unstructured":"EUCTR2013-001534-18-GB A study to investigate the effects aes-103 in patients with sickle cell disease www.who.int\/trialsearch\/Trial2.aspx?TrialID=EUCTR2013-001534-18-GB 2013"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0141|cit141","unstructured":"NCT01987908 Evaluation of different dose regimens of Aes-103 given for 28 days to subjects with stable sickle cell disease https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01987908"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0142|cit142","unstructured":"NCT02114203 Safety, tolerability, pharmacokinetics, and pharmacodynamics study of PF-04447943, co-administered with and without hydroxyurea, in subjects with stable sickle cell disease clinicaltrials.gov\/ct2\/show\/NCT02114203"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0143|cit143","unstructured":"NCT02560935 Primary prevention of stroke in children with SCD in Sub-Saharan Africa II (SPRING) clinicaltrials.gov\/ct2\/show\/NCT02560935"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0144|cit144","unstructured":"NCT02675790 Low dose hydroxyurea for secondary stroke prevention in children with sickle cell disease in Sub-Saharan Africa (SPRINT) clinicaltrials.gov\/ct2\/show\/NCT02675790"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0145|cit145","unstructured":"NCT02813850 Oxygen therapy and pregnancy in sickle cell disease (DRO2G) clinicaltrials.gov\/ct2\/show\/NCT02813850"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0146|cit146","unstructured":"NCT03128515 Optimizing hydroxyurea therapy in children with SCA in malaria endemic areas (NOHARM-MTD) clinicaltrials.gov\/ct2\/show\/NCT03128515"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0147|cit147","unstructured":"NCT03401112 A study of IMR-687 in adult patients With sickle cell anaemia (homozygous HbSS or sickle-\u03b20 thalassemia) clinicaltrials.gov\/ct2\/show\/NCT03401112"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0148|cit148","unstructured":"NCT03666806 Preventing stroke triggers in children with sickle cell anaemia in Mulago Hospital, Kampala (PREST ): a randomized control trial https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03666806"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0149|cit149","unstructured":"NCT03975894 TAPS2 Transfusion Antenatally in Pregnant Women With SCD (TAPS2) clinicaltrials.gov\/ct2\/show\/NCT03975894"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0150|cit150","unstructured":"NCT03976180 High-flow oxygen for vaso-occlusive pain crisis (OSONE) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03976180"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0151|cit151","unstructured":"NCT04084080 Sickle cell disease and cardiovascular risk - red cell exchange trial (SCD-CARRE) clinicaltrials.gov\/ct2\/show\/NCT04084080"},{"issue":"6","key":"10.1002\/14651858.CD012389.pub3-BIB0152|cit152","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ajh.21699","article-title":"The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up","volume":"85","author":"Steinberg","year":"2010","journal-title":"American Journal of Hematology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0153|cit153","unstructured":"EUCTR2017-000903-26 A phase 3, randomized, double-blind, placebo controlled study of voxelotor (GBT440) in pediatric participants with sickle cell disease and an open-label study in infants with sickle cell disease (HOPE Kids 2) clinicaltrialsregister.eu\/ctr-search\/trial\/2017-000903-26\/GB"},{"issue":"Supplement 2","key":"10.1002\/14651858.CD012389.pub3-BIB0154|cit154","first-page":"666","article-title":"Voxelotor dose extrapolation in a phase 3, randomized, double-blind, placebo-controlled study in pediatric patients with sickle cell disease (GBT440-032, hope kids 2)","volume":"2","author":"Washington","year":"2018","journal-title":"HemaSphere"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0155|cit155","unstructured":"NCT00850018 Examining cognitive function and brain abnormalities in adults with sickle cell disease - pilot intervention study clinicaltrials.gov\/ct2\/show\/NCT00850018"},{"issue":"21","key":"10.1002\/14651858.CD012389.pub3-BIB0156|cit156","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1182\/blood.V116.21.3221.3221","article-title":"A Randomized trial of the safety and benefit of transfusion vs. standard care in the prevention of sickle cell-related complications in adults: a preliminary report from the phase I NHLBI comprehensive sickle cell centers (cscc) study of neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adult patients with sickle cell disease","volume":"116","author":"Vichinsky","year":"2010","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0157|cit157","unstructured":"Vichinsky E Neumayr L Gold JI Weiner MW Kasten J Truran D A randomised trial of the safety and benefit of transfusion vs. standard care in the prevention of sickle cell-related complications in adults: a preliminary report from the phase II NHLBI comprehensive sickle cell centers (CSCC) study of neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adult patients with sickle cell disease 52nd Ash Annual Meeting and Exposition; 2010 Dec 4-7; Orlando, Florida. 2010"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0158|cit158","unstructured":"NCT01389024 Hydroxyurea to prevent brain injury in sickle cell disease (HUPrevent) clinicaltrials.gov\/ct2\/show\/NCT01389024"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0159|cit159","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1182\/blood-2010-12-326298","article-title":"Discontinuing prophylactic transfusions increases the risk of silent brain infarction in children with sickle cell disease: data from STOP II","volume":"118","author":"Abboud","year":"2011","journal-title":"Blood"},{"issue":"10","key":"10.1002\/14651858.CD012389.pub3-BIB0160|cit160","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.amjmed.2008.04.040","article-title":"Surgical and obstetric outcomes in adults with sickle cell disease","volume":"121","author":"Adam","year":"2008","journal-title":"American Journal of Medicine"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0161|cit161","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJM199807023390102","article-title":"Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography","volume":"339","author":"Adams","year":"1998","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0162|cit162","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ajh.10143","article-title":"Silent brain infarcts are rare in Kuwaiti children with sickle cell disease and high Hb F","volume":"70","author":"Adekile","year":"2002","journal-title":"Americal Journal of Hematology"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0163|cit163","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1182\/blood-2011-03-325258","article-title":"Fetal hemoglobin in sickle cell anemia","volume":"118","author":"Akinsheye","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0164|cit164","doi-asserted-by":"crossref","first-page":"e2013062","DOI":"10.4084\/mjhid.2013.062","article-title":"Sickle cell disease: management options and challenges in developing countries","volume":"5","author":"Ansong","year":"2013","journal-title":"Mediterranean Journal of Hematology and Infectious Diseases"},{"issue":"6 Pt 1","key":"10.1002\/14651858.CD012389.pub3-BIB0165|cit165","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1542\/peds.97.6.864","article-title":"Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease","volume":"97","author":"Armstrong","year":"1996","journal-title":"Pediatrics"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0166|cit166","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1542\/peds.2012-0283","article-title":"Developmental function in toddlers with sickle cell anemia","volume":"131","author":"Armstrong","year":"2013","journal-title":"Pediatrics"},{"issue":"7","key":"10.1002\/14651858.CD012389.pub3-BIB0167|cit167","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1182\/blood-2007-03-079665","article-title":"Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease","volume":"110","author":"Bernaudin","year":"2007","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0168|cit168","doi-asserted-by":"crossref","first-page":"1130-40; quiz 1","DOI":"10.1182\/blood-2010-06-293514","article-title":"Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort","volume":"117","author":"Bernaudin","year":"2011","journal-title":"Blood"},{"issue":"10","key":"10.1002\/14651858.CD012389.pub3-BIB0169|cit169","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1182\/blood-2014-09-599852","article-title":"Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia","volume":"125","author":"Bernaudin","year":"2015","journal-title":"Blood"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0170|cit170","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/08880010903360367","article-title":"Design of the silent cerebral infarct transfusion (SIT) trial","volume":"27","author":"Casella","year":"2010","journal-title":"Pediatric Hematology & Oncology"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0171|cit171","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/archdischild-2013-303773","article-title":"Sickle cell disease: a neglected chronic disease of increasing global health importance","volume":"100","author":"Chakravorty","year":"2015","journal-title":"Archives of Disease in Childhood"},{"issue":"20","key":"10.1002\/14651858.CD012389.pub3-BIB0172|cit172","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM199505183322001","article-title":"Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia","volume":"332","author":"Charache","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0173|cit173","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1182\/asheducation-2013.1.439","article-title":"Transfusion therapy for sickle cell disease: a balancing act","volume":"2013","author":"Chou","year":"2013","journal-title":"Hematology"},{"issue":"6","key":"10.1002\/14651858.CD012389.pub3-BIB0174|cit174","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1182\/blood-2013-03-490623","article-title":"High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors","volume":"122","author":"Chou","year":"2013","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0175|cit175","unstructured":"Veritas Health Innovation Covidence 2015"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0176|cit176","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/mrdd.20118","article-title":"Etiology of strokes in children with sickle cell anemia","volume":"12","author":"DeBaun","year":"2006","journal-title":"Mental Retardation & Developmental Disabilities Research Reviews"},{"issue":"20","key":"10.1002\/14651858.CD012389.pub3-BIB0177|cit177","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1182\/blood-2011-02-272682","article-title":"Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia","volume":"119","author":"DeBaun","year":"2012","journal-title":"Blood"},{"issue":"8","key":"10.1002\/14651858.CD012389.pub3-BIB0178|cit178","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1401731","article-title":"Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia","volume":"371","author":"DeBaun","year":"2014","journal-title":"New England Journal of Medicine"},{"issue":"7","key":"10.1002\/14651858.CD012389.pub3-BIB0179|cit179","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1182\/blood-2015-09-618579","article-title":"Central nervous system complications and management in sickle cell disease","volume":"127","author":"DeBaun","year":"2016","journal-title":"Blood"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0180|cit180","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1182\/asheducation-2016.1.632","article-title":"Prevention of central nervous system sequelae in sickle cell disease without evidence from randomized controlled trials:the case for a team-based learning collaborative","volume":"2016","author":"DeBaun","year":"2016","journal-title":"Hematology American Society of Hematology Education Program"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0181|cit181","unstructured":"Deeks JJ Higgins JPT Altman DG on behalf of the Cochrane Statistical Methods Group Chapter 9: Analysing data and undertaking meta-analysis. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"19","key":"10.1002\/14651858.CD012389.pub3-BIB0182|cit182","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1182\/blood-2012-01-406314","article-title":"Acute silent cerebral ischemia and infarction during acute anemia in children with and without sickle cell disease","volume":"120","author":"Dowling","year":"2012","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0183|cit183","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.2119\/molmed.2014.00187","article-title":"Advances in sickle cell therapies in the hydroxyurea era","volume":"20 Suppl 1","author":"Field","year":"2014","journal-title":"Molecular Medicine"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0184|cit184","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1172\/JCI30920","article-title":"Sickle cell disease: old discoveries, new concepts, and future promise","volume":"117","author":"Frenette","year":"2007","journal-title":"Journal of Clinical Investigation"},{"issue":"7526","key":"10.1002\/14651858.CD012389.pub3-BIB0185|cit185","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/515S1a","article-title":"Sickle-cell disease","volume":"515","author":"Gravitz","year":"2014","journal-title":"Nature"},{"issue":"6 Suppl 4","key":"10.1002\/14651858.CD012389.pub3-BIB0186|cit186","doi-asserted-by":"crossref","first-page":"S398","DOI":"10.1016\/j.amepre.2011.09.013","article-title":"Sickle cell disease in Africa. A neglected cause of early childhood mortality","volume":"41","author":"Grosse","year":"2011","journal-title":"American Journal of Preventive Medicine"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0187|cit187","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1182\/blood-2014-10-605964","article-title":"Higher-than-expected prevalence of silent cerebral infarcts in children with hemoglobin SC disease","volume":"125","author":"Guilliams","year":"2015","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0188|cit188","unstructured":"Higgins JPT Green S editor(s) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0189|cit189","unstructured":"Higgins JPT Deeks JJ editor(s) Chapter 7: Selecting studies and collecting data. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0190|cit190","unstructured":"Higgins JPT Altman DG Sterne JAC editor(s) Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0191|cit191","unstructured":"Higgins JPT Deeks JJ Altman DG editor(s) Chapter 16: Special topics in statistics. In: Higgins JPT, Green S, editor(s). Cochrane Handbook of Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0192|cit192","unstructured":"Howard J Transfusion therapy in sickle cell disease 25th Regional Congress of the International Society of Blood Transfusion in Conjunction with the 33rd Annual Conference of the British Blood Transfusion Society; 2015 Jun 27 - Jul 01; London, United Kingdom 2015"},{"issue":"6","key":"10.1002\/14651858.CD012389.pub3-BIB0193|cit193","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1182\/blood-2005-06-2373","article-title":"Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease","volume":"107","author":"Kato","year":"2006","journal-title":"Blood"},{"issue":"7","key":"10.1002\/14651858.CD012389.pub3-BIB0194|cit194","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ajh.20642","article-title":"Cerebrovascular disease associated with sickle cell pulmonary hypertension","volume":"81","author":"Kato","year":"2006","journal-title":"American Journal of Hematology"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0195|cit195","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1365-2141.2009.07753.x","article-title":"Silent infarcts in young children with sickle cell disease","volume":"146","author":"Kwiatkowski","year":"2009","journal-title":"British Journal of Haematology"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0196|cit196","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1182\/blood-2005-10-009506","article-title":"Stroke Prevention Trial in Sickle Cell Anemia (STOP): extended follow-up and final results","volume":"108","author":"Lee","year":"2006","journal-title":"Blood"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0197|cit197","unstructured":"Lefebvre C Manheimer E Glanville J Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0198|cit198","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1542\/peds.84.3.500","article-title":"Mortality in children and adolescents with sickle cell disease. Cooperative Study of Sickle Cell Disease","volume":"84","author":"Leikin","year":"1989","journal-title":"Pediatrics"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0199|cit199","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ajh.10376","article-title":"Silent brain infarcts in adult Kuwaiti sickle cell disease patients","volume":"73","author":"Marouf","year":"2003","journal-title":"American Journal of Hematology"},{"issue":"4","key":"10.1002\/14651858.CD012389.pub3-BIB0200|cit200","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-Analyses: the PRISMA Statement","volume":"151","author":"Moher","year":"2009","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0201|cit201","unstructured":"National Institute for Health and Care Excellence (NICE) Sickle cell disease http:\/\/cks.nice.org.uk\/sickle-cell-disease 2010"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0202|cit202","first-page":"64","article-title":"Sickle cell disease in the United States of America and Africa","volume-title":"Hematology (American Society of Hematology Education Program)","author":"Ohene-Frempong","year":"1999"},{"issue":"5","key":"10.1002\/14651858.CD012389.pub3-BIB0203|cit203","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007001.pub4","article-title":"Hematopoietic stem cell transplantation for people with sickle cell disease","author":"Oringanje","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"24","key":"10.1002\/14651858.CD012389.pub3-BIB0204|cit204","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8","article-title":"Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints","volume":"17","author":"Parmar","year":"1998","journal-title":"Statistics in Medicine"},{"issue":"12","key":"10.1002\/14651858.CD012389.pub3-BIB0205|cit205","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1001\/archneur.58.12.2017","article-title":"Silent infarcts in children with sickle cell anemia and abnormal cerebral artery velocity","volume":"58","author":"Pegelow","year":"2001","journal-title":"Archives of Neurology"},{"issue":"9861","key":"10.1002\/14651858.CD012389.pub3-BIB0206|cit206","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0140-6736(12)61229-X","article-title":"Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates","volume":"381","author":"Piel","year":"2012","journal-title":"Lancet"},{"issue":"7526","key":"10.1002\/14651858.CD012389.pub3-BIB0207|cit207","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/515S2a","article-title":"Epidemiology: a moving target","volume":"515","author":"Pleasants","year":"2014","journal-title":"Nature"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0208|cit208","first-page":"447","article-title":"Consequences and management of iron overload in sickle cell disease","volume":"1","author":"Porter","year":"2013","journal-title":"ASH Education Program Book"},{"issue":"5","key":"10.1002\/14651858.CD012389.pub3-BIB0209|cit209","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1586\/17474086.2015.1078235","article-title":"A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease","volume":"8","author":"Pule","year":"2015","journal-title":"Expert Review of Hematology"},{"issue":"9757","key":"10.1002\/14651858.CD012389.pub3-BIB0210|cit210","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0211|cit211","unstructured":"Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0212|cit212","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0213|cit213","doi-asserted-by":"crossref","first-page":"e100516","DOI":"10.1371\/journal.pone.0100516","article-title":"The co-inheritance of alpha-thalassemia and sickle cell anemia Is associated with better hematological indices and lower consultations rate in Cameroonian patients and could improve their survival","volume":"9","author":"Rumaney","year":"2014","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1002\/14651858.CD012389.pub3-BIB0214|cit214","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MAJ.0b013e3181c70e14","article-title":"Delayed hemolytic transfusion reaction in sickle cell disease","volume":"339","author":"Scheunemann","year":"2010","journal-title":"American Journal of the Medical Sciences"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0215|cit215","unstructured":"Sch\u00fcnemann HJ Oxman AD Higgins JPT Vist GE Glasziou P Guyatt GH Chapter 11: Presenting results and \u2018Summary of findings\u2019 tables. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0216|cit216","unstructured":"Sch\u00fcnemann HJ Oxman AD Vist GE Higgins JPT Deeks JJ Glasziou P Chapter 12: Interpreting results and drawing conclusions. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"1","key":"10.1002\/14651858.CD012389.pub3-BIB0217|cit217","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bjh.12336","article-title":"Interplay between coagulation and vascular inflammation in sickle cell disease","volume":"162","author":"Sparkenbaugh","year":"2013","journal-title":"British Journal of Haematology"},{"issue":"8","key":"10.1002\/14651858.CD012389.pub3-BIB0218|cit218","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/ajh.23232","article-title":"Genetic modifiers of sickle cell disease","volume":"87","author":"Steinberg","year":"2012","journal-title":"American Journal of Hematology"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0219|cit219","unstructured":"Sterne JAC Egger M Moher D editor(s) Chapter 10: Addressing reporting biases. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"key":"10.1002\/14651858.CD012389.pub3-BIB0220|cit220","doi-asserted-by":"crossref","unstructured":"Tierney JF Stewart LA Ghersi D Burdett S Sydes MR Practical methods for incorporating summary time-to-event data into meta-analysis Trials 2007 16","DOI":"10.1186\/1745-6215-8-16"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0221|cit221","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/2141-9248.105655","article-title":"Prevalence of human immunodeficiency virus transmission among transfused children with sickle cell anemia in Enugu Nigeria","volume":"2","author":"Ubesie","year":"2012","journal-title":"Annals of Medical and Health Sciences Research"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0222|cit222","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/bjh.13819","article-title":"Risk factor analysis of cerebral white matter hyperintensities in children with sickle cell disease","volume":"172","author":"Land","year":"2016","journal-title":"British Journal of Haematology"},{"issue":"11","key":"10.1002\/14651858.CD012389.pub3-BIB0223|cit223","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1161\/01.STR.25.11.2153","article-title":"Middle cerebral artery velocity changes during transfusion in sickle cell anemia","volume":"25","author":"Venketasubramanian","year":"1994","journal-title":"Stroke"},{"issue":"2","key":"10.1002\/14651858.CD012389.pub3-BIB0224|cit224","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.bbmt.2009.10.005","article-title":"Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease","volume":"16","author":"Walters","year":"2010","journal-title":"Biology of Blood and Marrow Transplantation"},{"issue":"9778","key":"10.1002\/14651858.CD012389.pub3-BIB0225|cit225","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0140-6736(11)60355-3","article-title":"Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)","volume":"377","author":"Wang","year":"2011","journal-title":"Lancet"},{"issue":"10","key":"10.1002\/14651858.CD012389.pub3-BIB0226|cit226","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012389","article-title":"Interventions for preventing silent cerebral infarcts in people with sickle cell disease","author":"Estcourt","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD012389.pub3-BIB0227|cit227","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012389.pub2","article-title":"Interventions for preventing silent cerebral infarcts in people with sickle cell disease","author":"Estcourt","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T14:14:10Z","timestamp":1722694450000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD012389.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Cystic Fibrosis and Genetic Disorders Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,6]]},"references-count":227,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd012389.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,6]]}}}