{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:55:39Z","timestamp":1790502939153,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd012499","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000}}],"reference-count":96,"publisher":"Wiley","issue":"1","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd012499.pub2","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T18:09:56Z","timestamp":1495044596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Methadone for neuropathic pain in adults"],"prefix":"10.1002","volume":"2021","author":[{"given":"Ewan D","family":"McNicol","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine; Tufts Medical Center; Boston MA USA"},{"name":"Department of Pharmacy; Tufts Medical Center; Boston Massachusetts USA"},{"name":"Pain Research, Education and Policy (PREP) Program, Department of Public Health and Community Medicine; Tufts University School of Medicine; Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKenzie C","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Pharmacy Practice; Southern Illinois University Edwardsville; Edwardsville IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Schumann","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine,; VA Boston Healthcare System; West Roxbury Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"10.1002\/14651858.CD012499.pub2-BIB0001|cit1","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1191\/0269216303pm815oa","article-title":"Low-dose methadone has an analgesic effect in neuropathic pain: a double-blind randomized controlled crossover trial","volume":"17","author":"Morley","year":"2003","journal-title":"Palliative Medicine"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0002|cit2","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1212\/WNL.59.7.1015","article-title":"Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial","volume":"59","author":"Raja","year":"2002","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0003|cit3","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.6061\/clinics\/2013(07)25","article-title":"Methadone in post-herpetic neuralgia: a pilot proof-of-concept study","volume":"68","author":"Teixeira","year":"2013","journal-title":"Clinics"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ejca.2016.06.025","article-title":"Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer","volume":"65","author":"Haumann","year":"2016","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0005|cit5","unstructured":"Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: Randomized, Double Blind, Active-controlled Clinical Trial clinicaltrials.gov\/ct2\/show\/NCT02233452"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0006|cit6","unstructured":"Methadone in Neuropathic Pain clinicaltrials.gov\/ct2\/show\/NCT01205516"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0007|cit7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S1474-4422(11)70281-2","article-title":"Chronic pain: genes, plasticity, and phenotypes","volume":"11","author":"Baron","year":"2012","journal-title":"Lancet Neurology"},{"issue":"3","key":"10.1002\/14651858.CD012499.pub2-BIB0008|cit8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jpain.2003.12.004","article-title":"Clinical characteristics and economic costs of patients with painful neuropathic disorders","volume":"5","author":"Berger","year":"2004","journal-title":"Journal of Pain"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0009|cit9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1533-2500.2008.00244.x","article-title":"Clinical and economic characteristics of patients with painful neuropathic disorders in Germany","volume":"9","author":"Berger","year":"2009","journal-title":"Pain Practice"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2377-12-8","article-title":"Clinical characteristics and patterns of healthcare utilization in patients with painful neuropathic disorders in UK general practice: a retrospective cohort study","volume":"12","author":"Berger","year":"2012","journal-title":"BMC Neurology"},{"issue":"3","key":"10.1002\/14651858.CD012499.pub2-BIB0011|cit11","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.pain.2007.08.013","article-title":"Prevalence of chronic pain with neuropathic characteristics in the general population","volume":"136","author":"Bouhassira","year":"2008","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0012|cit12","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0304-3959(91)90179-2","article-title":"Local toxicity with subcutaneous methadone. Experience of two centers","volume":"45","author":"Bruera","year":"1991","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0013|cit13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1089\/10966210252785097","article-title":"Methadone use in cancer patients with pain: a review","volume":"5","author":"Bruera","year":"2002","journal-title":"Journal of Palliative Medicine"},{"issue":"7","key":"10.1002\/14651858.CD012499.pub2-BIB0014|cit14","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S1474-4422(12)70134-5","article-title":"The role of the immune system in the generation of neuropathic pain","volume":"11","author":"Calvo","year":"2012","journal-title":"Lancet Neurology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0015|cit15","unstructured":"Centers for Disease Control and Prevention Prescription painkiller overdoses: use and abuse of methadone as a painkiller, 2012 www.cdc.gov\/vitalsigns\/MethadoneOverdoses\/index.html"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0016|cit16","unstructured":"Centers for Disease Control and Prevention Opioid painkiller prescribing www.cdc.gov\/vitalsigns\/opioid-prescribing\/index.html"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.amjmed.2007.10.009","article-title":"A community-based evaluation of sudden death associated with therapeutic levels of methadone","volume":"121","author":"Chugh","year":"2008","journal-title":"American Journal of Medicine"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s005200000180","article-title":"Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration","volume":"9","author":"Davis","year":"2001","journal-title":"Supportive Care in Cancer"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"f2304","DOI":"10.1136\/bmj.f2304","article-title":"Influence of trial sample size on treatment effect estimates: meta-epidemiological study","volume":"346","author":"Dechartres","year":"2013","journal-title":"BMJ"},{"issue":"6","key":"10.1002\/14651858.CD012499.pub2-BIB0020|cit20","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1001\/jama.2014.8166","article-title":"Association between analytic strategy and estimates of treatment outcomes in meta-analyses","volume":"312","author":"Dechartres","year":"2014","journal-title":"JAMA"},{"issue":"11","key":"10.1002\/14651858.CD012499.pub2-BIB0021|cit21","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1016\/j.pain.2014.08.014","article-title":"The effect of oxcarbazepine in peripheral neuropathic pain depends on pain phenotype: a randomised, double-blind, placebo-controlled phenotype-stratified study","volume":"155","author":"Demant","year":"2014","journal-title":"Pain"},{"issue":"9","key":"10.1002\/14651858.CD012499.pub2-BIB0022|cit22","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010111","article-title":"Topical capsaicin (low concentration) for chronic neuropathic pain in adults","author":"Derry","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"10.1002\/14651858.CD012499.pub2-BIB0023|cit23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010958.pub2","article-title":"Topical lidocaine for neuropathic pain in adults","author":"Derry","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0024|cit24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007393.pub4","article-title":"Topical capsaicin (high concentration) for chronic neuropathic pain in adults","author":"Derry","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0025|cit25","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jpain.2007.09.005","article-title":"Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations","volume":"9","author":"Dworkin","year":"2008","journal-title":"Journal of Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1016\/j.pain.2013.06.004","article-title":"Interventional management of neuropathic pain: NeuPSIG recommendations","volume":"154","author":"Dworkin","year":"2013","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analysis involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0028|cit28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0304-3959(93)90125-9","article-title":"Methadone in the management of cancer pain: a review","volume":"51","author":"Fainsinger","year":"1993","journal-title":"Pain"},{"issue":"7","key":"10.1002\/14651858.CD012499.pub2-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1002\/j.1532-2149.2012.00282.x","article-title":"Neuropathic pain needs systematic classification","volume":"17","author":"Finnerup","year":"2013","journal-title":"European Journal of Pain"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0030|cit30","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1212\/WNL.48.2.332","article-title":"Development and preliminary evaluation of a pain measure specific to neuropathic pain: the Neuropathic Pain Scale","volume":"48","author":"Galer","year":"1997","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0032|cit32","first-page":"152","article-title":"The use of methadone in the care of the dying","volume":"4","author":"Gannon","year":"1997","journal-title":"European Journal of Palliative Care"},{"issue":"7","key":"10.1002\/14651858.CD012499.pub2-BIB0033|cit33","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010692.pub3","article-title":"Oxycodone for neuropathic pain in adults","author":"Gaskell","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0034|cit34","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1399-6576.2007.01486.x","article-title":"Prevalence of self-reported neuropathic pain and impact on quality of life: a prospective representative survey","volume":"52","author":"Gustorff","year":"2008","journal-title":"Acta Anaesthesiologica Scandinavica"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0035|cit35","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jclinepi.2012.01.006","article-title":"GRADE guidelines: 11. Making an overall rating of confidence in effect estimates for a single outcome and for all outcomes","volume":"66","author":"Guyatt","year":"2013","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0036|cit36","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jclinepi.2012.01.012","article-title":"GRADE guidelines: 12. Preparing summary of findings tables - binary outcomes","volume":"66","author":"Guyatt","year":"2013","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0037|cit37","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2296-9-26","article-title":"Primary care incidence and treatment of four neuropathic pain conditions: a descriptive study, 2002-2005","volume":"9","author":"Hall","year":"2008","journal-title":"BMC Family Practice"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0038|cit38","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/cpt.19","article-title":"Individualized pharmacological treatment of neuropathic pain","volume":"97","author":"Helfert","year":"2015","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0039|cit39","unstructured":"Higgins JPT Altman DG Sterne JAC Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0040|cit40","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.pain.2009.09.017","article-title":"How do changes in pain severity levels correspond to changes in health status and function in patients with painful diabetic peripheral neuropathy?","volume":"149","author":"Hoffman","year":"2010","journal-title":"Pain"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0041|cit41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0042|cit42","doi-asserted-by":"crossref","unstructured":"Jensen TS Baron R Haanp\u00e4\u00e4 M Kalso E Loeser JD Rice AS A new definition of neuropathic pain Pain 2011 152 10 2204 5 10.1016\/j.pain.2011.06.017","DOI":"10.1016\/j.pain.2011.06.017"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0043|cit43","doi-asserted-by":"publisher","first-page":"f7339","DOI":"10.1136\/bmj.f7339","article-title":"Drugs for neuropathic pain","volume":"347","author":"Kalso","year":"2013","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0044|cit44","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1159\/000110284","article-title":"Epidemiology and clinical features of idiopathic trigeminal neuralgia and glossopharyngeal neuralgia: similarities and differences, Rochester, Minnesota, 1945-1984","volume":"10","author":"Katusic","year":"1991","journal-title":"Neuroepidemiology"},{"issue":"1-3","key":"10.1002\/14651858.CD012499.pub2-BIB0045|cit45","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.pain.2009.08.023","article-title":"Incidence of facial pain in the general population","volume":"147","author":"Koopman","year":"2009","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.7326\/0003-4819-150-6-200903170-00103","article-title":"QTc interval screening in methadone treatment","volume":"150","author":"Krantz","year":"2009","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0047|cit47","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1080\/10550881003684798","article-title":"Pharmacotherapy in the treatment of addiction: methadone","volume":"29","author":"Kreek","year":"2010","journal-title":"Journal of Addictive Diseases"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"224","DOI":"10.7326\/0003-4819-107-2-224","article-title":"Meta-analysis in clinical research","volume":"107","author":"L'Abb\u00e9","year":"1987","journal-title":"Annals of Internal Medicine"},{"issue":"6","key":"10.1002\/14651858.CD012499.pub2-BIB0049|cit49","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s12325-010-0036-3","article-title":"Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain","volume":"27","author":"Lange","year":"2010","journal-title":"Advances in Therapy"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0050|cit50","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007115.pub3","article-title":"Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia","author":"Lunn","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0051|cit51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0885-3924(99)00020-2","article-title":"Subcutaneous methadone in terminally ill patients: manageable local toxicity","volume":"18","author":"Mathew","year":"1999","journal-title":"Journal of Pain and Symptom Management"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/15360280802537225","article-title":"Opioid side effects and their treatment in patients with chronic cancer and noncancer pain","volume":"22","author":"McNicol","year":"2008","journal-title":"Journal of Pain & Palliative Care Pharmacotherapy"},{"issue":"8","key":"10.1002\/14651858.CD012499.pub2-BIB0053|cit53","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006146.pub2","article-title":"Opioids for neuropathic pain","author":"McNicol","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0054|cit54","volume-title":"An Evidence-Based Resource for Pain Relief","author":"McQuay","year":"1998"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0055|cit55","volume-title":"Health Care Needs Assessment, 3rd Series","author":"McQuay","year":"2007"},{"issue":"3","key":"10.1002\/14651858.CD012499.pub2-BIB0056|cit56","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0304-3959(98)00140-7","article-title":"Size is everything - large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects","volume":"78","author":"Moore","year":"1998","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0057|cit57","first-page":"15","volume-title":"Systematic Reviews in Pain Research: Methodology Refined","author":"Moore","year":"2008"},{"issue":"3","key":"10.1002\/14651858.CD012499.pub2-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007076.pub2","article-title":"Pregabalin for acute and chronic pain in adults","author":"Moore","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD012499.pub2-BIB0059|cit59","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.pain.2010.05.011","article-title":"\"Evidence\" in chronic pain - establishing best practice in the reporting of systematic reviews","volume":"150","author":"Moore","year":"2010","journal-title":"Pain"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0060|cit60","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.pain.2010.02.039","article-title":"Fibromyalgia: moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain","volume":"149","author":"Moore","year":"2010","journal-title":"Pain"},{"issue":"3","key":"10.1002\/14651858.CD012499.pub2-BIB0061|cit61","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.pain.2010.07.013","article-title":"Numbers-needed-to-treat analyses - do timing, dropouts, and outcome matter? Pooled analysis of two randomized, placebo-controlled chronic low back pain trials","volume":"151","author":"Moore","year":"2010","journal-title":"Pain"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0062|cit62","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1136\/ard.2009.107805","article-title":"Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice","volume":"69","author":"Moore","year":"2010","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"5","key":"10.1002\/14651858.CD012499.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.pain.2010.11.030","article-title":"Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen\/paracetamol combinations after third molar extraction","volume":"152","author":"Moore","year":"2011","journal-title":"Pain"},{"issue":"6","key":"10.1002\/14651858.CD012499.pub2-BIB0064|cit64","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1097\/EJA.0b013e328343c569","article-title":"Mean analgesic consumption is inappropriate for testing analgesic efficacy in post-operative pain: analysis and alternative suggestion","volume":"28","author":"Moore","year":"2011","journal-title":"European Journal of Anaesthesiology"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0065|cit65","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.pain.2011.10.004","article-title":"Estimate at your peril: imputation methods for patient withdrawal can bias efficacy outcomes in chronic pain trials using responder analyses","volume":"153","author":"Moore","year":"2012","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0066|cit66","doi-asserted-by":"publisher","first-page":"f2690","DOI":"10.1136\/bmj.f2690","article-title":"Expect analgesic failure; pursue analgesic success","volume":"346","author":"Moore","year":"2013","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD012499.pub2-BIB0067|cit67","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/anae.12148","article-title":"Pain measures and cut-offs - 'no worse than mild pain' as a simple, universal outcome","volume":"68","author":"Moore","year":"2013","journal-title":"Anaesthesia"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0068|cit68","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/papr.12050","article-title":"The costs and consequences of adequately managed chronic non-cancer pain and chronic neuropathic pain","volume":"14","author":"Moore","year":"2014","journal-title":"Pain Practice"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0069|cit69","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/j.1532-2149.2013.00341.x","article-title":"Duloxetine use in chronic painful conditions - individual patient data responder analysis","volume":"18","author":"Moore","year":"2014","journal-title":"European Journal of Pain"},{"issue":"4","key":"10.1002\/14651858.CD012499.pub2-BIB0070|cit70","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007938.pub3","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","author":"Moore","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"10","key":"10.1002\/14651858.CD012499.pub2-BIB0071|cit71","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010902.pub2","article-title":"Oral nonsteroidal anti-inflammatory drugs for neuropathic pain","author":"Moore","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"10.1002\/14651858.CD012499.pub2-BIB0072|cit72","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008242.pub3","article-title":"Amitriptyline for neuropathic pain in adults","author":"Moore","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1155\/2014\/754693","article-title":"Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society","volume":"19","author":"Moulin","year":"2014","journal-title":"Pain Research and Management"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0074|cit74","unstructured":"National Institute for Health and Care Excellence (NICE) Neuropathic pain - pharmacological management: the pharmacological management of neuropathic pain in adults in non-specialist settings, 2013 www.nice.org.uk\/guidance\/cg173"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0075|cit75","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003971.pub4","article-title":"Methadone for cancer pain","author":"Nicholson","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0076|cit76","doi-asserted-by":"publisher","first-page":"c3515","DOI":"10.1136\/bmj.c3515","article-title":"Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study","volume":"341","author":"N\u00fcesch","year":"2010","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD012499.pub2-BIB0077|cit77","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1526-4637.2009.00685.","article-title":"Patient-centered perspective on treatment outcomes in chronic pain","volume":"11","author":"O'Brien","year":"2010","journal-title":"Pain Medicine"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0078|cit78","unstructured":"Palliative and Supportive Care Group PaPaS author and referee guidance papas.cochrane.org\/papas-documents"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3959(94)90086-8","article-title":"Trigeminal neuralgia: the role of self-sustaining discharge in the trigeminal ganglion","volume":"56","author":"Rappaport","year":"1994","journal-title":"Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1001\/jamainternmed.2014.6294","article-title":"Out-of-hospital mortality among patients receiving methadone for noncancer pain","volume":"175","author":"Ray","year":"2015","journal-title":"JAMA Internal Medicine"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0081|cit81","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0082|cit82","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0304-3959(96)03286-1","article-title":"An update on the clinical use of methadone for cancer pain","volume":"70","author":"Ripamonti","year":"1997","journal-title":"Pain"},{"issue":"9","key":"10.1002\/14651858.CD012499.pub2-BIB0083|cit83","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.vaccine.2005.09.026","article-title":"The burden of herpes zoster: a prospective population based study","volume":"24","author":"Scott","year":"2006","journal-title":"Vaccine"},{"issue":"5","key":"10.1002\/14651858.CD012499.pub2-BIB0084|cit84","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011604.pub2","article-title":"Hydromorphone for neuropathic pain in adults","author":"Stannard","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD012499.pub2-BIB0085|cit85","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/j.1365-2125.2008.03200.","article-title":"Enriched enrolment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review","volume":"66","author":"Straube","year":"2008","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0086|cit86","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/1471-2474-11-150","article-title":"Pregabalin in fibromyalgia - responder analysis from individual patient data","volume":"11","author":"Straube","year":"2010","journal-title":"BMC Musculoskeletal Disorders"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0087|cit87","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1471-2377-8-","article-title":"Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials","volume":"8","author":"Sultan","year":"2008","journal-title":"BMC Neurology"},{"issue":"4","key":"10.1002\/14651858.CD012499.pub2-BIB0088|cit88","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jpain.2005.11.008","article-title":"The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey","volume":"7","author":"Torrance","year":"2006","journal-title":"Journal of Pain"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11916-009-0006-0","article-title":"Methadone: a new old drug with promises and pitfalls","volume":"13","author":"Trafton","year":"2009","journal-title":"Current Pain and Headache Reports"},{"issue":"18","key":"10.1002\/14651858.CD012499.pub2-BIB0090|cit90","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","article-title":"Neuropathic pain: redefinition and a grading system for clinical and research purposes","volume":"70","author":"Treede","year":"2008","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD012499.pub2-BIB0091|cit91","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic pain in the general population: a systematic review of epidemiological studies","volume":"155","author":"Hecke","year":"2014","journal-title":"Pain"},{"issue":"9","key":"10.1002\/14651858.CD012499.pub2-BIB0092|cit92","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.vaccine.2008.12.024","article-title":"Estimating the cost-effectiveness of vaccination against herpes zoster in England and Wales","volume":"27","author":"Hoek","year":"2009","journal-title":"Vaccine"},{"issue":"4","key":"10.1002\/14651858.CD012499.pub2-BIB0093|cit93","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype\u00a0to reveal neural mechanisms","volume":"73","author":"Hehn","year":"2012","journal-title":"Neuron"},{"issue":"9859","key":"10.1002\/14651858.CD012499.pub2-BIB0094|cit94","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"issue":"11","key":"10.1002\/14651858.CD012499.pub2-BIB0095|cit95","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010567.pub2","article-title":"Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews","author":"Wiffen","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD012499.pub2-BIB0096|cit96","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008025.pub2","article-title":"Methadone for chronic non-cancer pain in adults","author":"Haroutiunian","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD012499.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T02:36:23Z","timestamp":1669170983000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD012499.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Pain, Palliative and Supportive Care Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,17]]},"references-count":96,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd012499.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,17]]}}}