{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:09:00Z","timestamp":1790197740773,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd012557.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000}}],"reference-count":210,"publisher":"Wiley","issue":"1","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd012557.pub3","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T11:46:16Z","timestamp":1673610376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Baclofen for alcohol use disorder"],"prefix":"10.1002","volume":"2023","author":[{"given":"Roberta","family":"Agabio","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology; University of Cagliari; Monserrato (CA) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosella","family":"Saulle","sequence":"additional","affiliation":[{"name":"Department of Epidemiology; Lazio Regional Health Service; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"R\u00f6sner","sequence":"additional","affiliation":[{"name":"Forel Klinik; Ellikon an der Thur Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Minozzi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology; Lazio Regional Health Service; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"issue":"9603","key":"10.1002\/14651858.CD012557.pub3-BIB0001|cit1","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1016\/S0140-6736(07)61814-5","article-title":"Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study","volume":"370","author":"Addolorato","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/alcalc\/agr017","article-title":"Dose\u2013response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial","volume":"46","author":"Addolorato","year":"2011","journal-title":"Alcohol and Alcoholism"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/alcalc\/agr017","article-title":"Dose\u2013response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial","volume":"46","author":"Addolorato","year":"2011","journal-title":"Alcohol and Alcoholism"},{"issue":"12","key":"10.1002\/14651858.CD012557.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.euroneuro.2016.10.006","article-title":"Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: a multicentre, randomised, double-blind controlled trial","volume":"26","author":"Beraha","year":"2017","journal-title":"European Neuropsychopharmacology"},{"issue":"8","key":"10.1002\/14651858.CD012557.pub3-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/0269881118780010","article-title":"Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein?","volume":"32","author":"Beraha","year":"2018","journal-title":"Journal of Psychopharmacology"},{"issue":"12","key":"10.1002\/14651858.CD012557.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.euroneuro.2016.10.006","article-title":"Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: a multicentre, randomised, double-blind controlled trial","volume":"26","author":"Beraha","year":"2017","journal-title":"European Neuropsychopharmacology"},{"issue":"8","key":"10.1002\/14651858.CD012557.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/0269881118780010","article-title":"Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein?","volume":"32","author":"Beraha","year":"2018","journal-title":"Journal of Psychopharmacology"},{"issue":"11","key":"10.1002\/14651858.CD012557.pub3-BIB0008|cit8","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1111\/j.1530-0277.2010.01273.x","article-title":"Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial","volume":"34","author":"Garbutt","year":"2010","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0009|cit9","first-page":"178A","article-title":"Feasibility and tolerability of a combination of naltrexone and baclofen for alcohol dependence: a pilot study","volume":"34","author":"Garbutt","year":"2010","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0010|cit10","first-page":"178A","article-title":"Feasibility and tolerability of a combination of naltrexone and baclofen for alcohol dependence: a pilot study","volume":"34","author":"Garbutt","year":"2010","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"13","key":"10.1002\/14651858.CD012557.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1038\/s41386-021-01055-w","article-title":"Efficacy and tolerability of baclofen in a U.S. community population with alcohol use disorder: a dose\u2013response, randomized, controlled trial","volume":"46","author":"Garbutt","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0012|cit12","unstructured":"Efficacy and safety of high-dose baclofen for alcohol dependence www.clinicaltrials.gov\/ct2\/show\/NCT01980706"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0013|cit13","first-page":"65A","article-title":"Efficacy and tolerability of high-dose baclofen in a U.S. community population: a randomized, placebo-controlled trial","volume":"42","author":"Pedersen","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"13","key":"10.1002\/14651858.CD012557.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1038\/s41386-021-01055-w","article-title":"Efficacy and tolerability of baclofen in a U.S. community population with alcohol use disorder: a dose\u2013response, randomized, controlled trial","volume":"46","author":"Garbutt","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0015|cit15","unstructured":"Efficacy and safety of high-dose baclofen for alcohol dependence www.clinicaltrials.gov\/ct2\/show\/NCT01980706"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0016|cit16","first-page":"65A","article-title":"Efficacy and tolerability of high-dose baclofen in a U.S. community population: a randomized, placebo-controlled trial","volume":"42","author":"Pedersen","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"7","key":"10.1002\/14651858.CD012557.pub3-BIB0017|cit17","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1111\/add.13787.","article-title":"The safety and efficacy of baclofen to reduce alcohol use in veterans with chronic hepatitis C: a randomized controlled trial","volume":"112","author":"Hauser","year":"2017","journal-title":"Addiction"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11055-016-0379-6","article-title":"Efficacy and safety of the use of baclofen in the treatment of alcohol dependent (a double-blind, randomized, placebo-controlled pilot study)","volume":"47","author":"Krupitskii","year":"2017","journal-title":"Neuroscience and Behavioral Physiology"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.17116\/jnevro20151156153-62","article-title":"Double blind placebo controlled randomized pilot clinical trial of baclofen (Baclosan\u00ae) for alcohol dependence","volume":"115","author":"Krupitsky","year":"2015","journal-title":"Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"650","DOI":"10.4103\/psychiatry.IndianJPsychiatry_201_19","article-title":"A comparative study on the safety and efficacy of naltrexone versus baclofen versus acamprosate in the management of alcohol dependence","volume":"62","author":"Kumar","year":"2020","journal-title":"Indian Journal of Psychiatry"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0021|cit21","first-page":"265","article-title":"A double-blind, placebo-controlled randomized pilot study of the effects of baclofen on alcohol-tobacco co-use and alcohol cue-reactivity in alcoholic smokers","volume":"7","author":"Bollinger","year":"2014","journal-title":"Clinical and Translational Science"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/npp.2015.29","article-title":"Baclofen as a pharmacotherapy for the treatment of concurrent alcohol and nicotine dependence: a double-blind, placebo-controlled, randomized trial. Erratum for: Neuropsychopharmacology. 2014 Dec;39 Suppl 1:S1-647","volume":"40","author":"Farokhnia","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0023|cit23","first-page":"S340","article-title":"Baclofen as a pharmacotherapy for the treatment of concurrent alcohol and nicotine dependence: a double-blind, placebo-controlled, randomized trial","volume":"39","author":"Farokhnia","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0024|cit24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00213-014-3652-9","article-title":"A preliminary double-blind, placebo-controlled randomized study of baclofen effects in alcoholic smokers","volume":"232","author":"Leggio","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0025|cit25","first-page":"48","article-title":"A study of comparative efficacy of baclofen vs acamprosate in reducing alcohol craving and abuse","volume":"-","author":"Mishra","year":"2010","journal-title":"Orissa Journal of Psychiatry"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1093\/alcalc\/agu062","article-title":"Baclofen for the treatment of alcohol dependence and possible role of comorbid anxiety","volume":"49","author":"Morley","year":"2014","journal-title":"Alcohol and Alcoholism"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1093\/alcalc\/agu062","article-title":"Baclofen for the treatment of alcohol dependence and possible role of comorbid anxiety","volume":"49","author":"Morley","year":"2014","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3389\/fpsyt.2018.00576","article-title":"Baclofen response in alcohol dependent patients concurrently receiving antidepressants: secondary analysis from the BacALD study","volume":"9","author":"Heng","year":"2018","journal-title":"Frontiers in Psychiatry"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0029|cit29","first-page":"65A","article-title":"Baclofen reduces alcohol cue-induced fMRI brain activation in treatment seeking alcohol dependent individuals","volume":"42","author":"Logge","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"e2722","DOI":"10.1002\/hup.2722","article-title":"Baclofen modulates cardiovascular responses to appetitive cues in treatment-seeking alcohol use disorder individuals","volume":"35","author":"Logge","year":"2020","journal-title":"Human Psychopharmacology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0031|cit31","first-page":"20A","article-title":"Dose-specific baclofen effects on brain structure, function and treatment responses: neuroimaging findings from the BacALD trial","volume":"45","author":"Logge","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/alcalc\/agy083","article-title":"Executive functioning moderates responses to appetitive cues: a study in severe alcohol use disorder and alcoholic liver disease","volume":"54","author":"Logge","year":"2019","journal-title":"Alcohol and Alcoholism"},{"issue":"5","key":"10.1002\/14651858.CD012557.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00213-019-05192-5","article-title":"Baclofen attenuates fMRI alcohol cue reactivity in treatment-seeking alcohol dependent individuals","volume":"238","author":"Logge","year":"2021","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0034|cit34","first-page":"S75","article-title":"Baclofen for treatment of alcohol use disorder: secondary analyses and implications of the Australian BacALD trial","volume":"38","author":"Morley","year":"2019","journal-title":"Drug and Alcohol Review"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0035|cit35","first-page":"41A","article-title":"Exploration of the modulating role of the GABAb receptor polymorphism rs29220 on response to baclofen in alcohol dependent patients","volume":"45","author":"Morley","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1192\/bjp.2018.13","article-title":"Baclofen in the treatment of alcohol dependence with or without liver disease: multisite, randomised, double-blind, placebo-controlled trial","volume":"212","author":"Morley","year":"2018","journal-title":"British Journal of Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"e12702","DOI":"10.1111\/adb.12702","article-title":"Brain GABA levels are reduced in alcoholic liver disease: a proton magnetic resonance spectroscopy study","volume":"25","author":"Morley","year":"2020","journal-title":"Addiction Biology"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cct.2013.08.002","article-title":"The efficacy and biobehavioural basis of baclofen in the treatment of alcoholic liver disease (BacALD): study protocol for a randomised controlled trial","volume":"36","author":"Morley","year":"2013","journal-title":"Contemporary Clinical Trials"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.euroneuro.2021.02.010","article-title":"High-dose baclofen attenuates insula activation during anticipatory anxiety in treatment-seeking alcohol dependant individuals: preliminary findings from a pharmaco-fMRI study","volume":"46","author":"Morley","year":"2021","journal-title":"European Neuropsychopharmacology"},{"issue":"12","key":"10.1002\/14651858.CD012557.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/add.14373","article-title":"Moderation of baclofen response by a GABAB receptor polymorphism: results from the BacALD randomized controlled trial","volume":"113","author":"Morley","year":"2018","journal-title":"Addiction"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0041|cit41","first-page":"65A","article-title":"Baclofen administration attenuates insula response during anticipatory anxiety in alcohol dependent patients","volume":"42","author":"Morley","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0042|cit42","first-page":"53A","article-title":"Moderation of baclofen on the daily relationship between craving and alcohol use: results from the Australian BacALD trial","volume":"45","author":"Morley","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0043|cit43","first-page":"65A","article-title":"Moderation of baclofen response by a GABAb receptor polymorphism","volume":"42","author":"Morley","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/alcalc\/agz026","article-title":"Clinical predictors of response to baclofen in the treatment of alcohol use disorder: results from the BacALD trial","volume":"54","author":"Rombouts","year":"2019","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3389\/fpsyt.2018.00576","article-title":"Baclofen response in alcohol dependent patients concurrently receiving antidepressants: secondary analysis from the BacALD study","volume":"9","author":"Heng","year":"2018","journal-title":"Frontiers in Psychiatry"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0046|cit46","first-page":"65A","article-title":"Baclofen reduces alcohol cue-induced fMRI brain activation in treatment seeking alcohol dependent individuals","volume":"42","author":"Logge","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"e2722","DOI":"10.1002\/hup.2722","article-title":"Baclofen modulates cardiovascular responses to appetitive cues in treatment-seeking alcohol use disorder individuals","volume":"35","author":"Logge","year":"2020","journal-title":"Human Psychopharmacology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0048|cit48","first-page":"20A","article-title":"Dose-specific baclofen effects on brain structure, function and treatment responses: neuroimaging findings from the BacALD trial","volume":"45","author":"Logge","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/alcalc\/agy083","article-title":"Executive functioning moderates responses to appetitive cues: a study in severe alcohol use disorder and alcoholic liver disease","volume":"54","author":"Logge","year":"2019","journal-title":"Alcohol and Alcoholism"},{"issue":"5","key":"10.1002\/14651858.CD012557.pub3-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00213-019-05192-5","article-title":"Baclofen attenuates fMRI alcohol cue reactivity in treatment-seeking alcohol dependent individuals","volume":"238","author":"Logge","year":"2021","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0051|cit51","first-page":"S75","article-title":"Baclofen for treatment of alcohol use disorder: secondary analyses and implications of the Australian BacALD trial","volume":"38","author":"Morley","year":"2019","journal-title":"Drug and Alcohol Review"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0052|cit52","first-page":"41A","article-title":"Exploration of the modulating role of the GABAb receptor polymorphism rs29220 on response to baclofen in alcohol dependent patients","volume":"45","author":"Morley","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1192\/bjp.2018.13","article-title":"Baclofen in the treatment of alcohol dependence with or without liver disease: multisite, randomised, double-blind, placebo-controlled trial","volume":"212","author":"Morley","year":"2018","journal-title":"British Journal of Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"e12702","DOI":"10.1111\/adb.12702","article-title":"Brain GABA levels are reduced in alcoholic liver disease: a proton magnetic resonance spectroscopy study","volume":"25","author":"Morley","year":"2020","journal-title":"Addiction Biology"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cct.2013.08.002","article-title":"The efficacy and biobehavioural basis of baclofen in the treatment of alcoholic liver disease (BacALD): study protocol for a randomised controlled trial","volume":"36","author":"Morley","year":"2013","journal-title":"Contemporary Clinical Trials"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.euroneuro.2021.02.010","article-title":"High-dose baclofen attenuates insula activation during anticipatory anxiety in treatment-seeking alcohol dependant individuals: preliminary findings from a pharmaco-fMRI study","volume":"46","author":"Morley","year":"2021","journal-title":"European Neuropsychopharmacology"},{"issue":"12","key":"10.1002\/14651858.CD012557.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/add.14373","article-title":"Moderation of baclofen response by a GABAB receptor polymorphism: results from the BacALD randomized controlled trial","volume":"113","author":"Morley","year":"2018","journal-title":"Addiction"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0058|cit58","first-page":"65A","article-title":"Baclofen administration attenuates insula response during anticipatory anxiety in alcohol dependent patients","volume":"42","author":"Morley","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0059|cit59","first-page":"53A","article-title":"Moderation of baclofen on the daily relationship between craving and alcohol use: results from the Australian BacALD trial","volume":"45","author":"Morley","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/alcalc\/agz026","article-title":"Clinical predictors of response to baclofen in the treatment of alcohol use disorder: results from the BacALD Trial","volume":"54","author":"Rombouts","year":"2019","journal-title":"Alcohol and Alcoholism"},{"issue":"11","key":"10.1002\/14651858.CD012557.pub3-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.euroneuro.2018.08.507","article-title":"Effects of high-dose baclofen on cue reactivity in alcohol dependence: a randomized, placebo-controlled pharmaco-fMRI study","volume":"28","author":"Beck","year":"2018","journal-title":"European Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.psychres.2018.12.095","article-title":"Total and acylated ghrelin plasma levels as potential long-term response markers in alcohol-dependent patients receiving high-dose of the GABA-B receptor agonist baclofen","volume":"272","author":"Geisel","year":"2019","journal-title":"Psychiatry Research"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1055\/s-0043-124189","article-title":"Hypothalamic-pituitary-adrenocortical axis activity in alcohol-dependent patients during treatment with high-dose baclofen","volume":"52","author":"Geisel","year":"2019","journal-title":"Pharmacopsychiatry"},{"issue":"8","key":"10.1002\/14651858.CD012557.pub3-BIB0064|cit64","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.euroneuro.2015.04.002","article-title":"High-dose baclofen for the treatment of alcohol dependence (BACLAD study): a randomized, placebo-controlled trial","volume":"25","author":"Muller","year":"2015","journal-title":"European Neuropsychopharmacology"},{"issue":"S1","key":"10.1002\/14651858.CD012557.pub3-BIB0065|cit65","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1016\/S0924-9338(15)31243-8","article-title":"Individually titrated high-dose baclofen for the treatment of alcohol dependence (BACLAD study) \u2013 a randomized controlled trial","volume":"30","author":"Muller","year":"2015","journal-title":"European Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0066|cit66","first-page":"126A","article-title":"Baclofen desensitizes the fronto-striatal reward network in alcohol dependent patients: a randomized, placebo-controlled pharmaco FMRI trial","volume":"42","author":"Pelz","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0067|cit67","first-page":"246A","article-title":"Baclofen desensitizes insular gain anticipation in alcohol-dependent patients \u2013 a randomized, placebo-controlled, patient-tailored pharmaco fMRI trial","volume":"43","author":"Pelz","year":"2019","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0068|cit68","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jsat.2014.11.007","article-title":"Baclofen as add-on to standard psychosocial treatment for alcohol dependence: a randomized, double-blind, placebo-controlled trial with 1 year follow-up","volume":"52","author":"Ponizovsky","year":"2015","journal-title":"Journal of Substance Abuse Treatment"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0069|cit69","first-page":"163","article-title":"A randomized, placebo-controlled study of high-dose baclofen in alcohol-dependent patients. The Alpadir study","volume":"142","author":"Pouchain","year":"2018","journal-title":"Exercer-La Revue Francophone De Medecine Generale"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/alcalc\/agx030","article-title":"A randomized, placebo-controlled study of high-dose baclofen in alcohol-dependent patients \u2013 the ALPADIR Study","volume":"52","author":"Reynaud","year":"2017","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0071|cit71","first-page":"215a","article-title":"Baclofen for the treatment of alcohol drinkers (Bacloville)","volume":"38","author":"Jaury","year":"2014","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"7","key":"10.1002\/14651858.CD012557.pub3-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/add.14927","article-title":"Titrated baclofen for high-risk alcohol consumption: a randomized placebo-controlled trial in out-patients with 1-year follow-up","volume":"115","author":"Rigal","year":"2020","journal-title":"Addiction"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/alcalc\/37.5.504","article-title":"Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomised controlled study","volume":"37","author":"Addolorato","year":"2002","journal-title":"Alcohol & Alcoholism"},{"issue":"10","key":"10.1002\/14651858.CD012557.pub3-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1097\/01.ALC.0000141640.48924.14","article-title":"Baclofen for alcohol dependence: a preliminary open-label study","volume":"28","author":"Flannery","year":"2004","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/00952990.2016.1240797","article-title":"Randomized open-label trial of baclofen for relapse prevention in alcohol dependence","volume":"43","author":"Gupta","year":"2017","journal-title":"American Journal of Drug and Alcohol Abuse"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0076|cit76","unstructured":"Comparison of baclofen and topiramate in the treatment of alcohol dependence ctri.nic.in\/Clinicaltrials\/pdf_generate.php?trialid=13646"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/ipj.ipj_57_19","article-title":"Comparison between baclofen and topiramate in alcohol dependence: a prospective study","volume":"28","author":"Jose","year":"2019","journal-title":"Indian Journal of Psychiatry"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4103\/psychiatry.IndianJPsychiatry_103_20","article-title":"Integrated intervention program for alcoholism improves impulsiveness and disadvantageous reward processing\/risk-taking","volume":"62","author":"Kumar","year":"2020","journal-title":"Indian Journal of Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0079|cit79","first-page":"187","article-title":"Baclofen as a novel pharmacotherapy for alcohol dependence: preliminary findings from a human laboratory double-blind placebo-controlled randomized study","volume":"36","author":"Leggio","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0080|cit80","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.pbb.2012.11.013","article-title":"A human laboratory pilot study with baclofen in alcoholic individuals","volume":"103","author":"Leggio","year":"2013","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0081|cit81","first-page":"S335","article-title":"Baclofen is more efficacious than oral naltrexone in individuals with severe alcohol dependence for maintaining abstinence \u2013 a preliminary report","volume":"48","author":"Karthik","year":"2018","journal-title":"European Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0082|cit82","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/jgh.12006","article-title":"A dose\u2013response effect of baclofen in reducing daily alcohol intake in alcohol-dependent subjects","volume":"27","author":"Sharma","year":"2012","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0083|cit83","unstructured":"Efficacy and safety of baclofen GRS for treatment of alcohol dependence, a 12 week study ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trialid=3752"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/01.jcp.0000270079.84758.fe","article-title":"Baclofen suppresses alcohol intake and craving for alcohol in a schizophrenic alcohol-dependent patient: a case report","volume":"27","author":"Agabio","year":"2007","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000347055","article-title":"Efficacy and tolerability of baclofen in substance use disorders: a systematic review","volume":"19","author":"Agabio","year":"2013","journal-title":"European Addiction Research"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0086|cit86","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3389\/fnins.2014.00140","article-title":"GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence","volume":"8","author":"Agabio","year":"2014","journal-title":"Frontiers in Neuroscience"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000433579","article-title":"Efficacy of medications approved for the treatment of alcohol dependence and alcohol withdrawal syndrome in female patients: a descriptive review","volume":"22","author":"Agabio","year":"2016","journal-title":"European Addiction Research"},{"issue":"12","key":"10.1002\/14651858.CD012557.pub3-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S2215-0366(18)30303-1","article-title":"Baclofen for the treatment of alcohol use disorder: the Cagliari Statement","volume":"5","author":"Agabio","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fpsyt.2018.00464","article-title":"Baclofen in the treatment of patients with alcohol use disorder and other mental health disorders","volume":"9","author":"Agabio","year":"2018","journal-title":"Frontiers in Psychiatry"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2174\/2589977512666201228121820","article-title":"Use of medications for the treatment of alcohol dependence: a retrospective study conducted in 2011\u20132012","volume":"13","author":"Agabio","year":"2021","journal-title":"Current Drug Research Reviews"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neubiorev.2020.12.030","article-title":"The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: a systematic review and meta-analysis","volume":"125","author":"Agabio","year":"2021","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0092|cit92","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005063.pub3","article-title":"Benzodiazepines for alcohol withdrawal","author":"Amato","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0093|cit93","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008537.pub2","article-title":"Efficacy and safety of pharmacological interventions for the treatment of the alcohol withdrawal syndrome","author":"Amato","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/alcalc\/agh130","article-title":"Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician","volume":"40","author":"Ameisen","year":"2005","journal-title":"Alcohol and Alcoholism"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0095|cit95","first-page":"20f13606","article-title":"Individualized, high-dose baclofen for reduction in alcohol intake in persons with high levels of consumption","volume":"81","author":"Andrade","year":"2020","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0096|cit96","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1980"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0097|cit97","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1987"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0098|cit98","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0099|cit99","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0100|cit100","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/CPAA.S32434","article-title":"Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review","volume":"5","author":"Brennan","year":"2013","journal-title":"Clinical Pharmacology"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/acps.12905","article-title":"Baclofen for alcohol use disorder \u2013 a systematic meta-analysis","volume":"138","author":"Bschor","year":"2018","journal-title":"Acta Psychiatrica Scandinavica"},{"issue":"42","key":"10.1002\/14651858.CD012557.pub3-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/alcalc\/agl091","article-title":"Suppression of symptoms of alcohol dependence and craving using high-dose baclofen","volume":"2","author":"Bucknam","year":"2006","journal-title":"Alcohol and Alcoholism"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s40265-021-01670-3","article-title":"Novel agents for the pharmacological treatment of alcohol use disorder","volume":"82","author":"Burnette","year":"2022","journal-title":"Drugs"},{"issue":"10200","key":"10.1002\/14651858.CD012557.pub3-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(19)31775-1","article-title":"Alcohol use disorders","volume":"394","author":"Carvalho","year":"2019","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0269881111408463","article-title":"Substitution therapy for alcoholism: time for a reappraisal?","volume":"26","author":"Chick","year":"2012","journal-title":"Journal of Psychopharmacology"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00213-003-1397-y","article-title":"Baclofen suppresses motivation to consume alcohol in rats","volume":"167","author":"Colombo","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fpsyt.2018.00475","article-title":"Suppressing effect of baclofen on multiple alcohol-related behaviors in laboratory animals","volume":"9","author":"Colombo","year":"2018","journal-title":"Frontiers in Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0108|cit108","unstructured":"Covidence Veritas Health Innovation"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tips.2004.11.004","article-title":"Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression","volume":"26","author":"Cryan","year":"2005","journal-title":"Trends in Pharmacological Sciences"},{"issue":"11","key":"10.1002\/14651858.CD012557.pub3-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2165\/00002018-200427110-00004","article-title":"A benefit\u2013risk assessment of baclofen in severe spinal spasticity","volume":"27","author":"Dario","year":"2004","journal-title":"Drug Safety"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3389\/fpsyt.2018.00506","article-title":"A review of the potential mechanisms of action of baclofen in alcohol use disorder","volume":"9","author":"Beaurepaire","year":"2018","journal-title":"Frontiers in Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3389\/fpsyt.2018.00708","article-title":"The use of baclofen as a treatment for alcohol use disorder: a clinical practice perspective","volume":"9","author":"Beaurepaire","year":"2019","journal-title":"Frontiers in Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0113|cit113","unstructured":"Deeks JJ Higgins JP Altman DG editor(s) on behalf of the Cochrane Statistical Methods Group Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s), Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (updated June 2017), Cochrane, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0114|cit114","first-page":"S340","article-title":"Baclofen as a pharmacotherapy for the treatment of concurrent alcohol and nicotine dependence: a double-blind, placebo-controlled, randomized trial","volume":"39","author":"Farokhnia","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"10.1002\/14651858.CD012557.pub3-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1001\/jamapsychiatry.2021.2274","article-title":"Association between mental health disorders and mortality among patients with COVID-19 in 7 countries: a systematic review and meta-analysis","volume":"78","author":"Fond","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jclinepi.2005.06.006","article-title":"Imputing missing standard deviations in meta-analyses can provide accurate results","volume":"59","author":"Furukawa","year":"2006","journal-title":"Journal of Clinical Epidemiology"},{"issue":"10152","key":"10.1002\/14651858.CD012557.pub3-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0140-6736(18)31310-2","article-title":"Alcohol use and burden for 195 countries and territories, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"392","author":"GBD 2016 Alcohol Collaborators","year":"2018","journal-title":"Lancet"},{"issue":"10352","key":"10.1002\/14651858.CD012557.pub3-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0140-6736(22)01438-6","article-title":"The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019","volume":"400","author":"GBD 2019 Cancer Risk Factors Collaborators","year":"2022","journal-title":"Lancet"},{"issue":"10347","key":"10.1002\/14651858.CD012557.pub3-BIB0119|cit119","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0140-6736(22)00847-9","article-title":"Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020","volume":"400","author":"GBD 2020 Alcohol Collaborators","year":"2022","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0120|cit120","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005190.pub2","article-title":"Psychotropic analgesic nitrous oxide for alcoholic withdrawal states","author":"Gillman","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0121|cit121","doi-asserted-by":"publisher","first-page":"106128","DOI":"10.1016\/j.addbeh.2019.106128","article-title":"The epidemiology of alcohol use disorders cross-nationally: findings from the World Mental Health Surveys","volume":"102","author":"Glantz","year":"2020","journal-title":"Addictive Behaviors"},{"issue":"19","key":"10.1002\/14651858.CD012557.pub3-BIB0122|cit122","first-page":"1490","article-title":"Grading quality of evidence and strength of recommendations","volume":"328","author":"GRADE Working Group","year":"2004","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0123|cit123","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime) 2015"},{"issue":"8","key":"10.1002\/14651858.CD012557.pub3-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/jamapsychiatry.2015.0584","article-title":"Epidemiology of DSM-5 alcohol use disorder: results From the National Epidemiologic Survey on Alcohol and Related Conditions III","volume":"72","author":"Grant","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"10.1002\/14651858.CD012557.pub3-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1001\/jamapsychiatry.2017.2161","article-title":"Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001\u20132002 to 2012\u20132013: results from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"74","author":"Grant","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/00952990.2016.1240797","article-title":"Randomized open-label trial of baclofen for relapse prevention in alcohol dependence","volume":"43","author":"Gupta","year":"2017","journal-title":"American Journal of Drug and Alcohol Abuse"},{"issue":"7560","key":"10.1002\/14651858.CD012557.pub3-BIB0127|cit127","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0128|cit128","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines 1. Introduction \u2013 GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"Suppl 7","key":"10.1002\/14651858.CD012557.pub3-BIB0129|cit129","first-page":"S3","article-title":"New Australian guidelines for the treatment of alcohol problems: an overview of recommendations","volume":"215","author":"Haber","year":"2021","journal-title":"Medical Journal of Australia"},{"issue":"8","key":"10.1002\/14651858.CD012557.pub3-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/jamapsychiatry.2021.1271","article-title":"Use of medications for alcohol use disorder in the US: results from the 2019 national survey on drug use and health","volume":"78","author":"Han","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0132|cit132","unstructured":"Higgins JP Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from training.cochrane.org\/handbook\/archive\/v5.1\/"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0133|cit133","unstructured":"Higgins JP Altman DG Sterne JA Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s), Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (updated June 2017), Cochrane, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ajp.2015.06.015","article-title":"High doses of baclofen as suicide attempt in patients with alcohol use disorders \u2013 a serious concern","volume":"17","author":"Holla","year":"2015","journal-title":"Asian Journal of Psychiatry"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/ije\/dyu115","article-title":"Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing patients to blind and nonblind sub-studies","volume":"43","author":"Hr\u00f3bjartsson","year":"2014","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0136|cit136","first-page":"215a","article-title":"Baclofen for the treatment of alcohol drinkers (Bacloville)","volume":"38","author":"Jaury","year":"2014","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/j.1530-0277.2011.01523.x","article-title":"The efficacy of disulfiram for the treatment of alcohol use disorder","volume":"35","author":"Jorgensen","year":"2011","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0138|cit138","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/ipj.ipj_57_19","article-title":"Comparison between baclofen and topiramate in alcohol dependence: a prospective study","volume":"28","author":"Jose","year":"2019","journal-title":"Indian Journal of Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12903-016-0208-x","article-title":"Significance bias: an empirical evaluation of the oral health literature","volume":"16","author":"Kagereki","year":"2016","journal-title":"BMC Oral Health"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012557.pub3-BIB0140|cit140","first-page":"S335","article-title":"Baclofen is more efficacious than oral naltrexone in individuals with severe alcohol dependence for maintaining abstinence \u2013 a preliminary report","volume":"48","author":"Karthik","year":"2018","journal-title":"European Psychiatry"},{"issue":"12","key":"10.1002\/14651858.CD012557.pub3-BIB0141|cit141","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1021\/acschemneuro.0c00254","article-title":"Classics in chemical neuroscience: baclofen","volume":"11","author":"Kent","year":"2020","journal-title":"Chemical Neuroscience"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0142|cit142","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0376-8716(93)90057-w","article-title":"Baclofen administration for the treatment of affective disorders in alcoholic patients","volume":"33","author":"Krupitsky","year":"1993","journal-title":"Drug and Alcohol Dependence"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4103\/psychiatry.IndianJPsychiatry_103_20","article-title":"Integrated intervention program for alcoholism improves impulsiveness and disadvantageous reward processing\/risk-taking","volume":"62","author":"Kumar","year":"2020","journal-title":"Indian Journal of Psychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0144|cit144","unstructured":"Lefebvre C Manheimer E Glanville J Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from training.cochrane.org\/handbook\/archive\/v5.1\/"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0145|cit145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/187152710790966614","article-title":"Effectiveness and safety of baclofen in the treatment of alcohol dependent patients","volume":"9","author":"Leggio","year":"2010","journal-title":"CNS & Neurological Disorders Drug Targets"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0146|cit146","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006266.pub2","article-title":"Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses","author":"Leone","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD012557.pub3-BIB0147|cit147","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2515\/therapie\/2014038","article-title":"Efficacy of baclofen on abstinence and craving in alcohol-dependent patients: a meta-analysis of randomized controlled trials","volume":"69","author":"Lesouef","year":"2014","journal-title":"Therapie"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0148|cit148","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008502.pub4","article-title":"Baclofen for alcohol withdrawal","author":"Liu","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0149|cit149","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/7854_2020_182","article-title":"GABAB receptors and alcohol use disorders: clinical studies","volume":"52","author":"Logge","year":"2022","journal-title":"Current Topics in Behavioral Neurosciences"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0150|cit150","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.alcohol.2005.08.003","article-title":"Baclofen-induced reduction of alcohol reinforcement in alcohol-preferring rats","volume":"36","author":"Maccioni","year":"2005","journal-title":"Alcohol"},{"issue":"7","key":"10.1002\/14651858.CD012557.pub3-BIB0151|cit151","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.alcohol.2009.09.030","article-title":"Role of the GABA(B) receptor in alcohol-seeking and drinking behavior","volume":"43","author":"Maccioni","year":"2009","journal-title":"Alcohol"},{"issue":"10","key":"10.1002\/14651858.CD012557.pub3-BIB0152|cit152","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1111\/j.1530-0277.2012.01782.x","article-title":"Comparison of the effect of the GABA\u0392 receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats","volume":"36","author":"Maccioni","year":"2012","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0153|cit153","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s40263-018-0596-3","article-title":"Potential of GABAB receptor positive allosteric modulators in the treatment of alcohol use disorder","volume":"33","author":"Maccioni","year":"2019","journal-title":"CNS Drugs"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0154|cit154","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41572-022-00406-1","article-title":"Hazardous drinking and alcohol use disorders","volume":"8","author":"MacKillop","year":"2022","journal-title":"Nature Reviews Disease Primers"},{"issue":"10190","key":"10.1002\/14651858.CD012557.pub3-BIB0155|cit155","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/S0140-6736(18)32744-2","article-title":"Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study","volume":"393","author":"Manthey","year":"2019","journal-title":"Lancet"},{"issue":"7","key":"10.1002\/14651858.CD012557.pub3-BIB0156|cit156","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s40273-021-01031-8","article-title":"What are the economic costs to society attributable to alcohol use? A systematic review and modelling study","volume":"39","author":"Manthey","year":"2021","journal-title":"Pharmacoeconomics"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0157|cit157","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.drugalcdep.2013.07.035","article-title":"Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence","volume":"133","author":"Manzardo","year":"2013","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0158|cit158","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.drugalcdep.2015.03.032","article-title":"Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity","volume":"152","author":"Manzardo","year":"2015","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0159|cit159","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-3-642-28720-6_202","article-title":"Modeling relapse in animals","volume":"13","author":"Martin-Fardon","year":"2013","journal-title":"Current Topics in Behavioral Neurosciences"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0160|cit160","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1124\/pharmrev.120.000206","article-title":"Sex- and gender-based pharmacological response to drugs","volume":"73","author":"Mauvais-Jarvis","year":"2021","journal-title":"Pharmacological Reviews"},{"issue":"3","key":"10.1002\/14651858.CD012557.pub3-BIB0161|cit161","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006754.pub4","article-title":"Anticonvulsants for alcohol withdrawal","author":"Minozzi","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0162|cit162","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003012.pub2","article-title":"Active placebos versus antidepressants for depression","author":"Moncrieff","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0163|cit163","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1360-0443.2006.01310.x","article-title":"Rates and predictors of relapse after natural and treated remission from alcohol use disorders","volume":"101","author":"Moos","year":"2006","journal-title":"Addiction"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0164|cit164","doi-asserted-by":"crossref","unstructured":"Morley KC Leung S Baillie A Haber PS The efficacy and biobehavioural basis of baclofen in the treatment of alcoholic liver disease (BacALD): study protocol for a randomised controlled trial Contemporary Clinical Trials 2013 36 2 348 55","DOI":"10.1016\/j.cct.2013.08.002"},{"issue":"10","key":"10.1002\/14651858.CD012557.pub3-BIB0165|cit165","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1080\/14656566.2021.1892641","article-title":"New approved and emerging pharmacological approaches to alcohol use disorder: a review of clinical studies","volume":"22","author":"Morley","year":"2021","journal-title":"Expert Opinion on Pharmacotherapy"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0166|cit166","doi-asserted-by":"crossref","first-page":"807269","DOI":"10.3389\/fgwh.2022.807269","article-title":"Sex as a potential moderator for baclofen response in the treatment of alcohol dependence","volume":"3","author":"Morley","year":"2022","journal-title":"Frontiers in Global Women's Health"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0167|cit167","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-0042-103592","article-title":"Current findings and mechanisms of action of disulfiram in the treatment of alcohol dependence","volume":"49","author":"Mutschler","year":"2016","journal-title":"Pharmacopsychiatry"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0168|cit168","unstructured":"Efficacy and safety of high-dose baclofen for alcohol dependence www.clinicaltrials.gov\/ct2\/show\/NCT01980706"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0169|cit169","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1037\/1089-2680.2.2.175","article-title":"Confirmation bias: a ubiquitous phenomenon in many guises","volume":"2","author":"Nickerson","year":"1998","journal-title":"Review of General Psychology"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0170|cit170","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008544.pub2","article-title":"Anticonvulsants for alcohol dependence","author":"Pani","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0171|cit171","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/JCP.0b013e31824929b2","article-title":"High-dose baclofen for treatment-resistant alcohol dependence","volume":"32","author":"Pastor","year":"2012","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0172|cit172","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010487","article-title":"Disulfiram for alcohol use disorder","author":"Pedersen","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0173|cit173","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/15563650.2017.1284330","article-title":"Self-poisoning with baclofen in alcohol-dependent patients: national reports to French Poison Control Centers, 2008\u20132013","volume":"55","author":"Pelissier","year":"2017","journal-title":"Clinical Toxicology"},{"issue":"7","key":"10.1002\/14651858.CD012557.pub3-BIB0174|cit174","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.euroneuro.2018.03.017","article-title":"Efficacy, tolerability, and safety of low-dose and high-dose baclofen in the treatment of alcohol dependence: a systematic review and meta-analysis","volume":"28","author":"Pierce","year":"2018","journal-title":"European Neuropsychopharmacology"},{"issue":"10","key":"10.1002\/14651858.CD012557.pub3-BIB0175|cit175","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1111\/ejn.12733","article-title":"GABA(B) modulation of dopamine release in the nucleus accumbens core","volume":"40","author":"Pitman","year":"2014","journal-title":"European Journal of Neuroscience"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0176|cit176","doi-asserted-by":"crossref","first-page":"e208279","DOI":"10.1001\/jamanetworkopen.2020.8279","article-title":"Combined pharmacotherapy and cognitive behavioral therapy for adults with alcohol or substance use disorders: a systematic review and meta-analysis","volume":"3","author":"Ray","year":"2020","journal-title":"JAMA Network Open"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0177|cit177","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1176\/appi.ajp.2017.1750101","article-title":"The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder","volume":"175","author":"Reus","year":"2018","journal-title":"American Journal of Psychiatry"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0178|cit178","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/17425255.2020.1740681","article-title":"Toxicological considerations in the prescription of baclofen for the treatment of substance use disorders","volume":"16","author":"Reynoard","year":"2020","journal-title":"Expert Opinion on Drug Metabolism & Toxicology"},{"issue":"9","key":"10.1002\/14651858.CD012557.pub3-BIB0179|cit179","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1111\/add.12231","article-title":"Alcohol use disorders and mortality: a systematic review and meta-analysis","volume":"108","author":"Roerecke","year":"2013","journal-title":"Addiction"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0180|cit180","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/JCP.0b013e3182860e84","article-title":"Baclofen for alcohol-dependence: anticraving or partial substitution?","volume":"33","author":"Rolland","year":"2013","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0181|cit181","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/alcalc\/agz082","article-title":"France grants an approval to baclofen for alcohol dependence","volume":"55","author":"Rolland","year":"2020","journal-title":"Alcohol and Alcoholism"},{"issue":"8","key":"10.1002\/14651858.CD012557.pub3-BIB0182|cit182","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1111\/add.14191","article-title":"Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis","volume":"113","author":"Rose","year":"2018","journal-title":"Addiction"},{"issue":"9","key":"10.1002\/14651858.CD012557.pub3-BIB0183|cit183","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004332.pub2","article-title":"Acamprosate for alcohol dependence","author":"R\u00f6sner","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD012557.pub3-BIB0184|cit184","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001867.pub3","article-title":"Opioid antagonists for alcohol dependence","author":"R\u00f6sner","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD012557.pub3-BIB0185|cit185","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008358.pub2","article-title":"Magnesium for alcohol withdrawal","author":"Sarai","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD012557.pub3-BIB0186|cit186","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1164\/rccm.200602-197ST","article-title":"An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations","volume":"174","author":"Sch\u00fcnemann","year":"2006","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0187|cit187","unstructured":"Kemstro\u00ae (oral baclofen tablets) package insert Monheim (Germany) 2003"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0188|cit188","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/jgh.12006","article-title":"A dose\u2013response effect of baclofen in reducing daily alcohol intake in alcohol-dependent subjects","volume":"27","author":"Sharma","year":"2012","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0189|cit189","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/S2468-2667(19)30231-2","article-title":"National, regional, and global burdens of disease from 2000 to 2016 attributable to alcohol use: a comparative risk assessment study","volume":"5","author":"Shield","year":"2020","journal-title":"Lancet Public Health"},{"issue":"7","key":"10.1002\/14651858.CD012557.pub3-BIB0190|cit190","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s40264-016-0416-y","article-title":"Safety and tolerability of pharmacological treatment of alcohol dependence: comprehensive review of evidence","volume":"39","author":"Sinclair","year":"2016","journal-title":"Drug Safety"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0191|cit191","doi-asserted-by":"crossref","first-page":"e87366","DOI":"10.1371\/journal.pone.0087366","article-title":"Disulfiram efficacy in the treatment of alcohol dependence: a meta-analysis","volume":"9","author":"Skinner","year":"2014","journal-title":"PLOS One"},{"issue":"10","key":"10.1002\/14651858.CD012557.pub3-BIB0192|cit192","doi-asserted-by":"crossref","first-page":"e011827","DOI":"10.1136\/bmjopen-2016-011827","article-title":"Birth cohort trends in the global epidemiology of alcohol use and alcohol-related harms in men and women: systematic review and metaregression","volume":"6","author":"Slade","year":"2016","journal-title":"BMJ Open"},{"issue":"9","key":"10.1002\/14651858.CD012557.pub3-BIB0193|cit193","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1176\/appi.ajp.2020.20040417","article-title":"New challenges in addiction medicine: COVID-19 infection in patients with alcohol and substance use disorders \u2013 the perfect storm","volume":"177","author":"Spagnolo","year":"2020","journal-title":"American Journal of Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0194|cit194","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000115677","article-title":"Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. A clinical trial","volume":"23","author":"Steardo","year":"1984","journal-title":"European Neurology"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0195|cit195","unstructured":"Sterne JA Egger M Moher D Boutron I Chapter 10: Addressing reporting biases. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s), Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (updated June 2017), Cochrane, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2"},{"issue":"11","key":"10.1002\/14651858.CD012557.pub3-BIB0196|cit196","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.euroneuro.2017.08.434","article-title":"Systematic review: baclofen dosing protocols for alcohol use disorders used in observational studies","volume":"27","author":"Thompson","year":"2017","journal-title":"European Neuropsychopharmacology"},{"issue":"4","key":"10.1002\/14651858.CD012557.pub3-BIB0197|cit197","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003352.pub4","article-title":"Dopaminergic antagonists for alcohol dependence","author":"Vaz de Lima","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"37","key":"10.1002\/14651858.CD012557.pub3-BIB0198|cit198","doi-asserted-by":"crossref","first-page":"15037","DOI":"10.1073\/pnas.1010654108","article-title":"Addiction: beyond dopamine reward circuitry","volume":"108","author":"Volkow","year":"2011","journal-title":"Proceedings of the National Academy of Sciences USA"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0199|cit199","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1530-0277.2006.00259.x","article-title":"The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats","volume":"31","author":"Walker","year":"2007","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"9","key":"10.1002\/14651858.CD012557.pub3-BIB0200|cit200","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/acer.12815","article-title":"Converging patterns of alcohol use and related outcomes among females and males in the United States, 2002 to 2012","volume":"39","author":"White","year":"2015","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0201|cit201","volume-title":"International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10)","author":"World Health Organization","year":"1992"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0202|cit202","unstructured":"World Health Organization International guide for monitoring alcohol consumption and related harm apps.who.int\/iris\/handle\/10665\/66529"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0203|cit203","unstructured":"World Health Organization Global status report on alcohol and health 2018 www.who.int\/publications\/i\/item\/9789241565639"},{"key":"10.1002\/14651858.CD012557.pub3-BIB0204|cit204","unstructured":"World Health Organization International Classification of Diseases 11th revision (ICD-11) World Health Organization 2019"},{"issue":"1","key":"10.1002\/14651858.CD012557.pub3-BIB0205|cit205","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/can.2016.0016","article-title":"Maintenance of blinding in clinical trials and the implications for studying analgesia using cannabinoids","volume":"1","author":"Wilsey","year":"2016","journal-title":"Cannabis and Cannabinoid Research"},{"issue":"10","key":"10.1002\/14651858.CD012557.pub3-BIB0206|cit206","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.tins.2009.06.004","article-title":"Roles for nigrostriatal \u2013 not just mesocorticolimbic\u2013dopamine in reward and addiction","volume":"32","author":"Wise","year":"2009","journal-title":"Trends in Neurosciences"},{"issue":"9","key":"10.1002\/14651858.CD012557.pub3-BIB0207|cit207","doi-asserted-by":"crossref","first-page":"eaax4043","DOI":"10.1126\/sciadv.aax4043","article-title":"Advances in the science and treatment of alcohol use disorder","volume":"5","author":"Witkiewitz","year":"2019","journal-title":"Science Advances"},{"issue":"14","key":"10.1002\/14651858.CD012557.pub3-BIB0208|cit208","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1523\/JNEUROSCI.4977-13.2014","article-title":"Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cues","volume":"34","author":"Young","year":"2014","journal-title":"Journal of Neuroscience"},{"issue":"2","key":"10.1002\/14651858.CD012557.pub3-BIB0209|cit209","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012557","article-title":"Baclofen for alcohol use disorder","author":"Minozzi","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD012557.pub3-BIB0210|cit210","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012557.pub2","article-title":"Baclofen for alcohol use disorder","author":"Minozzi","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:02:55Z","timestamp":1769763775000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD012557.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Drugs and Alcohol Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":210,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd012557.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,13]]}}}