{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:19:18Z","timestamp":1790745558735,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd012692","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000}}],"reference-count":99,"publisher":"Wiley","issue":"9","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd012692.pub2","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T10:02:15Z","timestamp":1567677735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Interventions for unexplained infertility: a systematic review and network meta-analysis"],"prefix":"10.1002","volume":"2019","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"Monash University; Department of Obstetrics and Gynaecology; Clayton VIC Australia 3168"},{"name":"The University of Adelaide; Robinson Research Institute and Adelaide Medical School; Adelaide SA Australia 5005"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora A","family":"Danhof","sequence":"additional","affiliation":[{"name":"Academic Medical Center, University of Amsterdam; Center for Reproductive Medicine; Meibergdreef 9 Amsterdam Netherlands 1105 AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raissa I","family":"Tjon-Kon-Fat","sequence":"additional","affiliation":[{"name":"Academic Medical Center, University of Amsterdam; Center for Reproductive Medicine; Meibergdreef 9 Amsterdam Netherlands 1105 AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinus JC","family":"Eijkemans","sequence":"additional","affiliation":[{"name":"UMC Utrecht; Department of Biostatistics and Research Support, Julius Center; PO Box 85500 Utrecht Netherlands 3508GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick MM","family":"Bossuyt","sequence":"additional","affiliation":[{"name":"Academic Medical Center, University of Amsterdam; Department of Clinical Epidemiology, Biostatistics and Bioinformatics; Room J1b-217, PO Box 22700 Amsterdam Netherlands 1100 DE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique H","family":"Mochtar","sequence":"additional","affiliation":[{"name":"Academic Medical Center, University of Amsterdam; Center for Reproductive Medicine; Meibergdreef 9 Amsterdam Netherlands 1105 AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulco","family":"van der Veen","sequence":"additional","affiliation":[{"name":"Amsterdan UMC, University of Amsterdam; Center for Reproductive Medicine; Meibergdreef 9 Amsterdam Netherlands 1105 AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siladitya","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Aberdeen Maternity Hospital; Obstetrics and Gynaecology; Foresterhill Aberdeen UK AB9 2ZD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Willem J","family":"Mol","sequence":"additional","affiliation":[{"name":"Monash University; Department of Obstetrics and Gynaecology; Clayton VIC Australia 3168"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelon","family":"van Wely","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam; Center for Reproductive Medicine; Meibergdreef 9 Amsterdam Netherlands 1105 AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0001|cit1","first-page":"519","article-title":"A randomised prospective trial of intrauterine insemination versus timed intercourse in superovulated cycles with clomiphene","volume":"120","author":"Agarwal","year":"2004","journal-title":"Indian Journal of Medical Research"},{"issue":"8","key":"10.1002\/14651858.CD012692.pub2-BIB0002|cit2","first-page":"614","article-title":"Superovulation and intrauterine insemination vs. superovulation alone in the treatment of unexplained infertility. A randomized study","volume":"41","author":"Arcaini","year":"1996","journal-title":"Journal of Reproductive Medicine"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0015-0282(16)56524-8","article-title":"Evaluation of clomiphene citrate and human chorionic gonadotropin treatment: a prospective, randomized, crossover study during intrauterine insemination cycles","volume":"61","author":"Arici","year":"1994","journal-title":"Fertility & Sterility"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1472-6874-9-35","article-title":"The INeS study: prevention of multiple pregnancies: a randomised controlled trial comparing IUI COH versus IVF e SET versus MNC IVF in couples with unexplained or mild male subfertility","volume":"9","author":"Bensdorp","year":"2009","journal-title":"BMC Women's Health"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0005|cit5","first-page":"i14-i17 O-037","article-title":"Preliminary comparative effectiveness of IVF with single embryo transfer or IVF in the modified natural cycle and IUI with hyperstimulation; a randomized trial (INeS trial)","volume":"28(Suppl 1)","author":"Bensdorp","year":"2013","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0006|cit6","first-page":"g7771","article-title":"Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation","volume":"350","author":"Bensdorp","year":"2015","journal-title":"BMJ (Online)"},{"issue":"72","key":"10.1002\/14651858.CD012692.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"a716","DOI":"10.1136\/bmj.a716","article-title":"Clomifene citrate or unstimulated intrauterine insemination compared with expectant management for unexplained infertility: pragmatic randomised controlled trial","volume":"337","author":"Bhattacharya","year":"2008","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/humrep\/deq315","article-title":"Clomifene citrate and intrauterine insemination as first-line treatments for unexplained infertility: are they cost-effective?","volume":"26","author":"Wordsworth","year":"2011","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0009|cit9","first-page":"S61","article-title":"The ESHRE multicentre trial on the treatment of unexplained infertility","volume":"54","author":"Crosignani","year":"1991","journal-title":"Fertility & Sterility"},{"issue":"7","key":"10.1002\/14651858.CD012692.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/oxfordjournals.humrep.a137468","article-title":"The ESHRE multicentre trial on the treatment of unexplained infertility: a preliminary report. European Society of Human Reproduction and Embryology","volume":"6","author":"Crosignani","year":"1991","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0011|cit11","first-page":"i76, O-188 Oral","article-title":"IVF with elective single embryo transfer versus IUI-COH in couples with unexplained subfertility and a poor prognosis: a multicentre RCT","volume":"24 Suppl 1","author":"Custers","year":"2009","journal-title":"Human Reproduction."},{"issue":"5","key":"10.1002\/14651858.CD012692.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.fertnstert.2011.08.005","article-title":"Couples with unexplained subfertility and unfavorable prognosis: a randomized pilot trial comparing the effectiveness of in vitro fertilization with elective single embryo transfer versus intrauterine insemination with controlled ovarian stimulation","volume":"96","author":"Custers","year":"2011","journal-title":"Fertility & Sterility"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0013|cit13","first-page":"i44, Abstract N","article-title":"IVF with single embryo transfer versus iui with ovarian hyperstimulation in couples with unexplained subfertility, an economic analysis","volume":"24 Suppl 1","author":"Rumste","year":"2009","journal-title":"Human Reproduction"},{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0015-0282(16)54009-6","article-title":"A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis","volume":"54","author":"Deaton","year":"1990","journal-title":"Fertility & Sterility"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/ajo.12168","article-title":"A randomised controlled trial of intra-uterine insemination versus in vitro fertilisation in patients with idiopathic or mild male infertility","volume":"54","author":"Elzeiny","year":"2014","journal-title":"Australian & New Zealand Journal of Obstetrics & Gynaecology"},{"issue":"10119","key":"10.1002\/14651858.CD012692.pub2-BIB0016|cit16","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0140-6736(17)32406-6","article-title":"Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial.","volume":"391","author":"Farquhar","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD012692.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0015-0282(16)60674-X","article-title":"Unexplained infertility: evaluation of treatment with clomiphene citrate and human chorionic gonadotropin","volume":"51","author":"Fisch","year":"1989","journal-title":"Fertility & Sterility"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.fertnstert.2006.07.268","article-title":"A randomized controlled trial to evaluate the efficacy of clomiphene citrate in unexplained infertility","volume":"86 Suppl 2","author":"George","year":"2006","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/09513599009012324","article-title":"Clomiphene treatment for women with unexplained infertility: placebo-controlled study of hormonal responses and conception rates","volume":"4","author":"Glazener","year":"1990","journal-title":"Gynecological Endocrinology"},{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.fertnstert.2014.03.012","article-title":"A randomized clinical trial to determine optimal infertility treatment in older couples: the Forty and Over Treatment Trial (FORT-T)","volume":"101","author":"Goldman","year":"2014","journal-title":"Fertility & Sterility"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.fertnstert.2009.04.022","article-title":"A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial","volume":"94","author":"Reindollar","year":"2010","journal-title":"Fertility & Sterility"},{"issue":"9197","key":"10.1002\/14651858.CD012692.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0140-6736(99)04002-7","article-title":"Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-effectiveness analysis","volume":"355","author":"Goverde","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0023|cit23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1056\/NEJM199901213400302","article-title":"Efficacy of superovulation and intrauterine insemination in the treatment of infertility. National Cooperative Reproductive Medicine Network","volume":"340","author":"Guzick","year":"1999","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0024|cit24","first-page":"273","article-title":"The use of clomiphene citrate with and without human chorionic gonadotropin","volume":"76","author":"Harrison","year":"1983","journal-title":"Irish Medical Journal"},{"issue":"Suppl 17","key":"10.1002\/14651858.CD012692.pub2-BIB0025|cit25","first-page":"43","article-title":"A randomised trial comparing the efficacy of ovarian stimulation and intrauterine insemination versus ovarian stimulation alone in the treatment of male infertility and unexplained infertility","volume":"105","author":"Ho","year":"1998","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"5","key":"10.1002\/14651858.CD012692.pub2-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/humrep\/deh209","article-title":"A multicentre randomized controlled trial of expectant management versus IVF in women with Fallopian tube patency","volume":"19","author":"Hughes","year":"2004","journal-title":"Human Reproduction (Oxford, England)"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0027|cit27","first-page":"S442","article-title":"Induction of ovulation with or without intrauterine insemination in cases of unexplained sterility","volume":"70","author":"Janko","year":"1998","journal-title":"Fertility and Sterility"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0015-0282(16)55799-9","article-title":"A prospective randomized trial of artificial insemination versus intercourse in cycles stimulated with human menopausal gonadotropin or clomiphene citrate","volume":"59","author":"Karlstrom","year":"1993","journal-title":"Fertility & Sterility"},{"issue":"1","key":"10.1002\/14651858.CD012692.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0015-0282(16)54426-4","article-title":"A prospective trial of intrauterine insemination of motile spermatozoa versus timed intercourse","volume":"56","author":"Kirby","year":"1991","journal-title":"Fertility & Sterility"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0030|cit30","first-page":"309","article-title":"Ovulation induction with clomiphene citrate for infertile couple","volume":"66","author":"Leanza","year":"2014","journal-title":"Minerva Ginecologica"},{"issue":"5","key":"10.1002\/14651858.CD012692.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0015-0282(16)53520-1","article-title":"Intrauterine insemination does and clomiphene citrate does not improve fecundity in couples with infertility due to male or idiopathic factors: a prospective, randomized, controlled study","volume":"53","author":"Martinez","year":"1990","journal-title":"Fertility & Sterility"},{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/S0015-0282(16)57965-5","article-title":"Ovulation induction with gonadotropins as sole treatment in infertile couples with open tubes: a randomized prospective comparison between intrauterine insemination and timed vaginal intercourse","volume":"64","author":"Melis","year":"1995","journal-title":"Fertility & Sterility"},{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.fertnstert.2017.03.028","article-title":"Intrauterine insemination with gonadotropin stimulation or in vitro fertilization for the treatment of unexplained subfertility: a randomized controlled trial","volume":"107","author":"Nandi","year":"2017","journal-title":"Fertility & Sterility"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0034|cit34","first-page":"i70-i71 Abstrac","article-title":"Controlled ovarian hyperstimulation (COH) and intrauterine insemination (IUI) vs. In Vitro fertilization (IVF) for the first line treatment of unexplained subfertility - a randomised controlled trial","volume":"31 Suppl 1","author":"Nandi","year":"2016","journal-title":"Human Reproduction"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD012692.pub2-BIB0035|cit35","first-page":"i113","article-title":"Effectiveness of intrauterine insemination with ovarian hyperstimulation in couples with an unexplained moderately reduced fertility","volume":"20","author":"Steures","year":"2005","journal-title":"21st Annual Meeting of the European Society of Human Reproduction and Embryology, Copenhagen, Denmark, 19-22 June 2005"},{"issue":"27","key":"10.1002\/14651858.CD012692.pub2-BIB0036|cit36","first-page":"1525","article-title":"[Intra-uterine insemination with controlled ovarian hyperstimulation compared to an expectant management in couples with unexplained subfertility and an intermediate prognosis: a randomised study]","volume":"152","author":"Steures","year":"2008","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"issue":"9531","key":"10.1002\/14651858.CD012692.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(06)69042-9","article-title":"Intrauterine insemination with controlled ovarian hyperstimulation versus expectant management for couples with unexplained subfertility and an intermediate prognosis: a randomised clinical trial","volume":"368","author":"Steures","year":"2006","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0038|cit38","first-page":"432","article-title":"Ovarian hyperstimulation and insemination vs IVF in unexplained infertility: results of randomized trial (poster)","volume":"21","author":"Buvat","year":"1993","journal-title":"Contraception, Fertilite, Sexualite"},{"issue":"12","key":"10.1002\/14651858.CD012692.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1093\/oxfordjournals.humrep.a135875","article-title":"Randomized comparison of ovulation induction with and without intrauterine insemination in the treatment of unexplained infertility","volume":"10","author":"Chung","year":"1995","journal-title":"Human Reproduction"},{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0015-0282(97)00394-4","article-title":"The effects of clomiphene citrate on normally ovulatory women","volume":"68","author":"Fujii","year":"1997","journal-title":"Fertility & Sterility"},{"issue":"4","key":"10.1002\/14651858.CD012692.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"S1 Abstract no.","DOI":"10.1016\/j.fertnstert.2010.07.003","article-title":"Pregnancy rates across multiple treatment cycles: data from the fast track and standard treatment (FASTT) trial","volume":"94 Suppl 1","author":"Goldman","year":"2010","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD012692.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0020-7292(94)02268-2","article-title":"Controlled ovarian hyperstimulation with or without intrauterine insemination for the treatment of unexplained infertility","volume":"48","author":"Gregoriou","year":"1995","journal-title":"International Journal of Gynaecology & Obstetrics"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0043|cit43","first-page":"303","article-title":"Unexplained infertility and ovulatory induction with menopausal gonadotropins","volume":"66","author":"Leanza","year":"2014","journal-title":"Minerva Ginecologica"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0015-0282(16)54112-0","article-title":"Pregnancy rates after timed intercourse or intrauterine insemination after human menopausal gonadotropin stimulation of normal ovulatory cycles: a controlled study","volume":"55","author":"Martinez","year":"1991","journal-title":"Fertility & Sterility"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0015-0282(16)59052-9","article-title":"Pharmacologic induction of multiple follicular development improves the success rate of artificial insemination with husband's semen in couples with male-related or unexplained infertility","volume":"47","author":"Melis","year":"1987","journal-title":"Fertility & Sterility"},{"issue":"11","key":"10.1002\/14651858.CD012692.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1471-0528.1991.tb15362.x","article-title":"Gamete intrafallopian transfer (GIFT) compared with intrauterine insemination in the treatment of unexplained infertility","volume":"98","author":"Murdoch","year":"1991","journal-title":"British Journal of Obstetrics & Gynaecology"},{"issue":"5","key":"10.1002\/14651858.CD012692.pub2-BIB0047|cit47","first-page":"780","article-title":"A randomized and longitudinal study of human menopausal gonadotropin with intrauterine insemination in the treatment of infertility","volume":"82","author":"Nulsen","year":"1993","journal-title":"Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0048|cit48","first-page":"112","article-title":"Controlled ovarian stimulation (superovulation) and intrauterine insemination for the treatment of unexplained and minor male factor infertility","volume":"10","author":"Prentice","year":"1995","journal-title":"Human Reproduction (Oxford, England)"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.fertnstert.2009.04.022","article-title":"A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial","volume":"94","author":"Reindollar","year":"2010","journal-title":"Fertility & Sterility"},{"issue":"5","key":"10.1002\/14651858.CD012692.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00404-006-0181-8","article-title":"Tamoxifen citrate for women with unexplained infertility","volume":"274","author":"Shokeir","year":"2006","journal-title":"Archives of Gynecology & Obstetrics"},{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0015-0282(16)55983-4","article-title":"A randomized trial of in vitro fertilization versus conventional treatment for infertility","volume":"59","author":"Soliman","year":"1993","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0052|cit52","first-page":"i214 Abstract n","article-title":"The natural conception rate in couples with unexplained or mild male subfertility scheduled for treatment with IVF-SET, IVF-MNC or IUI-COH (INeS trial)","volume":"29 suppl 1","author":"Tjon-Kon-Fat","year":"2014","journal-title":"Human Reproduction"},{"issue":"11","key":"10.1002\/14651858.CD012692.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/humrep\/12.11.2408","article-title":"Comparison between stimulated in-vitro fertilization and stimulated intrauterine insemination for the treatment of unexplained and mild male factor infertility","volume":"12","author":"Zayed","year":"1997","journal-title":"Human Reproduction"},{"issue":"4","key":"10.1002\/14651858.CD012692.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/oxfordjournals.humrep.a138096","article-title":"Homologous intra-uterine insemination has no advantage over timed natural intercourse when used in combination with ovulation induction for the treatment of unexplained infertility","volume":"8","author":"Zikopoulos","year":"1993","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0055|cit55","first-page":"42","article-title":"Comparison of intrauterine insemination with timed intercourse method in controlled ovarian hyperstimulation","volume":"10","author":"Zolghadri","year":"2012","journal-title":"Iranian Journal of Reproductive Medicine"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0056|cit56","unstructured":"NCT01992731 IUI vs. IVF\/ICSI in Women Aged 38-42 Years: A Prospective Randomized Controlled Trial clinicaltrials.gov\/ct2\/show\/NCT01992731"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0057|cit57","unstructured":"NCT02001870 Comparison of the Efficiency of Intra-uterine Insemination and in Vitro Fertilization in Women Over 37 Years (AMPAGE) clinicaltrials.gov\/ct2\/show\/NCT02001870"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0058|cit58","unstructured":"NCT02461173 Stimulated Intrauterine Insemination Cycles and Unstimulated Intrauterine Insemination Cycles in Couples With Unexplained Infertility clinicaltrials.gov\/ct2\/show\/NCT02461173"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0059|cit59","unstructured":"NCT03455426 Intrauterine Insemination With Letrozole Versus Intrauterine Insemination in Natural Cycle. A Randomised Controlled Trial clinicaltrials.gov\/ct2\/show\/NCT03455426"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0060|cit60","unstructured":"NTR5599 Intrauterine Insemination for Unexplained or Mild Male Subfertility trialregister.nl\/trialreg\/admin\/rctview.asp?TC=5599 2016"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0061|cit61","unstructured":"American Society for Reproductive Medicine Effectiveness and Treatment for Unexplained Infertility The practice committee of the American Society for Reproductive Medicine 2006"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0062|cit62","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003052","article-title":"Oral versus injectable ovulation induction agents for unexplained subfertility","author":"Athaullah","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/humrep\/dem046","article-title":"International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care","volume":"22","author":"Boivin","year":"2007","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/humrep\/dep341","article-title":"The relative contribution of IVF to the total ongoing pregnancy rate in a subfertile cohort","volume":"25","author":"Brandes","year":"2010","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/humrep\/deq349","article-title":"Unexplained infertility: overall ongoing pregnancy rate and mode of conception","volume":"26","author":"Brandes","year":"2011","journal-title":"Human Reproduction"},{"issue":"10","key":"10.1002\/14651858.CD012692.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"e76654","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"Chaimani","year":"2013","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1002\/14651858.CD012692.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1177\/1536867X1501500402","article-title":"Visualizing assumptions and results in network meta-analysis: the network graphs package","volume":"15","author":"Chaimani","year":"2015","journal-title":"Stata Journal"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0068|cit68","unstructured":"Institute of Social and Preventive Medicine, University of Bern 2017. Available from cinema.ispm.ch CINeMA: Confidence in Network Meta-Analysis [Software]. 2017"},{"issue":"9","key":"10.1002\/14651858.CD012692.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1093\/humrep\/dew123","article-title":"Prevalence of infertility and help seeking among 15 000 women and men","volume":"31","author":"Datta","year":"2016","journal-title":"Human Reproduction"},{"issue":"7-8","key":"10.1002\/14651858.CD012692.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/sim.3767","article-title":"Checking consistency in mixed treatment comparison meta-analysis","volume":"29","author":"Dias","year":"2010","journal-title":"Stat Med"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"hoy007","DOI":"10.1093\/hropen\/hoy007","article-title":"A protocol developing, disseminating and implementing a core outcome set for infertility","volume":"2018","author":"Duffy","year":"2018","journal-title":"Human Reproduction Open"},{"issue":"1","key":"10.1002\/14651858.CD012692.pub2-BIB0072|cit72","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/uog.18969","article-title":"How should we report outcomes in reproductive medicine?","volume":"51","author":"Gadalla","year":"2018","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1093\/humrep\/deg366","article-title":"Time to pregnancy: results of the German prospective study and impact of the management of infertility","volume":"18","author":"Gnoth","year":"2003","journal-title":"Human Reproduction"},{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.fertnstert.2016.02.001","article-title":"Evidence-based approach to unexplained infertility: a systematic review","volume":"105","author":"Gunn","year":"2016","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0075|cit75","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/jrsm.1044","article-title":"Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies","volume":"3","author":"Higgins","year":"2012","journal-title":"Research Synthesis Methods"},{"issue":"5","key":"10.1002\/14651858.CD012692.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.fertnstert.2018.01.008","article-title":"Ovarian stimulation\u00a0in\u00a0infertile\u00a0women\u00a0treated\u00a0with the use of\u00a0intrauterine\u00a0insemination: a\u00a0cohort study\u00a0from\u00a0China","volume":"109","author":"Huang","year":"2018","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD012692.pub2-BIB0078|cit78","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000057.pub2","article-title":"Clomiphene citrate for unexplained subfertility in women","author":"Hughes","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1136\/bmj.291.6510.1693","article-title":"Population study of causes, treatment, and outcome of infertility","volume":"291","author":"Hull","year":"1985","journal-title":"British Medical Journal (Clinical Research Ed.)"},{"issue":"9","key":"10.1002\/14651858.CD012692.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/humrep\/deh365","article-title":"Two new prediction rules for spontaneous pregnancy leading to live birth among subfertile couples, based on the synthesis of three previous models","volume":"19","author":"Hunault","year":"2004","journal-title":"Human Reproduction"},{"issue":"6","key":"10.1002\/14651858.CD012692.pub2-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1093\/humrep\/deh821","article-title":"Prospective validation of two models predicting pregnancy leading to live birth among untreated subfertile couples","volume":"20","author":"Hunault","year":"2005","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"g252","DOI":"10.1136\/bmj.g252","article-title":"Are we overusing IVF?","volume":"348","author":"Kamphuis","year":"2014","journal-title":"BMJ"},{"issue":"11","key":"10.1002\/14651858.CD012692.pub2-BIB0083|cit83","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpobgyn.2018.08.003","article-title":"Does intra-uterine insemination have a place in modern ART practice?","volume":"53","author":"Kandavel","year":"2018","journal-title":"Best Practice & Research: Clinical Obstetrics & Gynaecology"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.curobgyn.2005.01.003","article-title":"Prevention and management of ovarian hyperstimulation syndrome","volume":"15","author":"Mathur","year":"2005","journal-title":"Current Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0085|cit85","unstructured":"Fertility Guideline National Institute for Health and Care Excellence 2013"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0086|cit86","unstructured":"Guideline: unexplained subfertility Dutch Society of Obstetrics and Gynaecology (NVOG) 2010"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0140-6736(92)92425-F","article-title":"Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte","volume":"340","author":"Palermo","year":"1992","journal-title":"Lancet"},{"issue":"11","key":"10.1002\/14651858.CD012692.pub2-BIB0088|cit88","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003357.pub4","article-title":"In vitro fertilisation for unexplained subfertility","author":"Pandian","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"163-71","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple treatment meta-analysis: an overview and tutorial","volume":"64","author":"Salanti","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"7","key":"10.1002\/14651858.CD012692.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"e99682","DOI":"10.1371\/journal.pone.0099682","article-title":"Evaluating the quality of evidence from a network meta-analysis","volume":"9","author":"Salanti","year":"2014","journal-title":"PLoS One"},{"key":"10.1002\/14651858.CD012692.pub2-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0140-6736(78)92957-4","article-title":"Birth after the reimplantation of a human embryo","volume":"2","author":"Steptoe","year":"1978","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD012692.pub2-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/humrep\/dez017","article-title":"Are interventions in reproductive medicine assessed for plausible and clinically relevant effects? A systematic review of power and precision in trials and meta-analyses","volume":"34","author":"Stocking","year":"2019","journal-title":"Human Reproduction"},{"issue":"10","key":"10.1002\/14651858.CD012692.pub2-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1093\/humrep\/dev193","article-title":"Is IVF-served two different ways-more cost-effective than IUI with controlled ovarian hyperstimulation?","volume":"30","author":"Tjon-Kon-Fat","year":"2015","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/humrep\/dew309","article-title":"Natural conception: repeated predictions over time","volume":"32","author":"Eekelen","year":"2017","journal-title":"Human Reproduction"},{"issue":"1","key":"10.1002\/14651858.CD012692.pub2-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/humrep\/dey329","article-title":"Is IUI with ovarian stimulation effective in couples with unexplained subfertility?","volume":"34","author":"Eekelen","year":"2019","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD012692.pub2-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.rbmo.2013.10.021","article-title":"IVF with planned single-embryo transfer versus IUI with ovarian stimulation in couples with unexplained subfertility: an economic analysis","volume":"28","author":"Rumste","year":"2014","journal-title":"Reproductive Biomedicine Online"},{"issue":"2","key":"10.1002\/14651858.CD012692.pub2-BIB0097|cit97","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001838.pub5","article-title":"Intra-uterine insemination for unexplained subfertility","author":"Veltman-Verhulst","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD012692.pub2-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1177\/1536867X1501500403","article-title":"Network meta-analysis","volume":"15","author":"White","year":"2015","journal-title":"Stata Journal"},{"issue":"9","key":"10.1002\/14651858.CD012692.pub2-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/humrep\/dex234","article-title":"The International Glossary on Infertility and Fertility Care, 2017","volume":"32","author":"Zegers-Hochschild","year":"2017","journal-title":"Human Reproduction"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD012692.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T05:01:11Z","timestamp":1696654871000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD012692.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Gynaecology and Fertility Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,5]]},"references-count":99,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd012692.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,5]]}}}