{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:45:22Z","timestamp":1782125122942,"version":"3.54.5"},"update-to":[{"DOI":"10.1002\/14651858.cd013202","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000}}],"reference-count":165,"publisher":"Wiley","issue":"8","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd013202.pub2","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T21:45:12Z","timestamp":1599774312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants"],"prefix":"10.1002","volume":"2020","author":[{"given":"Matteo","family":"Bruschettini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Paediatrics; Lund University, Sk\u00e5ne University Hospital; Lund Sweden"},{"name":"Cochrane Sweden; Lund University, Sk\u00e5ne University Hospital; Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Romantsik","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Paediatrics; Lund University, Sk\u00e5ne University Hospital; Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Moreira","sequence":"additional","affiliation":[{"name":"Pediatrics, Division of Neonatology; University of Texas Health Science Center at San Antonio; San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ley","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Paediatrics; Lund University, Sk\u00e5ne University Hospital; Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Th\u00e9baud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Children's Hospital of Eastern Ontario; Ottawa Canada"},{"name":"Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research; Ottawa Canada"},{"name":"Department of Cellular and Molecular Medicine; University of Ottawa; Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0001|cit1","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.jpeds.2013.11.036","article-title":"Feasibility\u00a0of\u00a0autologous\u00a0cord\u00a0blood\u00a0cells\u00a0for\u00a0infants\u00a0with\u00a0hypoxic-ischemic encephalopathy","volume":"164","author":"Cotten","year":"2014","journal-title":"Journal of Pediatrics"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1016\/j.jcyt.2020.04.052","article-title":"Phase I trial of allogeneic umbilical cord tissue-derived mesenchymal stromal cells in neonates with hypoxic-ischemic encephalopathy","volume":"22","author":"Fisher","year":"2020","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0003|cit3","first-page":"4603","article-title":"Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety","volume":"10","author":"Tanaka","journal-title":"Scientific reports"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0004|cit4","unstructured":"Cotten CM Murtha A Goldberg R Smith PB Grotegut C Goldstein RF Autologous cord blood cells for infants with hypoxic-ischemic encephalopathy (HIE): a feasibility study Pediatric Academic Societies (PAS) Annual Meeting; 2011 April 30 to May 3; Denver (CO) 2011"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0005|cit5","doi-asserted-by":"crossref","unstructured":"Nabetani M Shintaku H Tsuji M Tamura M Kusuda S Hayakawa M Clinical trial study of autologous cord blood cell therapy for newborn with hypoxic ischemic encephalopathy in Japan European Journal of Pediatrics. 6th Congress of the European Academy of Paediatric Societies; 2016 Oct 21-24; Geneva (Switzerland) 2016","DOI":"10.26226\/morressier.57d034d0d462b802923830f7"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0006|cit6","unstructured":"Autologous umbilical cord blood mononuclear layer transfusion for neonates with encephalopathy: a pilot feasibility study apps.who.int\/trialsearch\/Trial2.aspx?TrialID=ACTRN12610000421033"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0007|cit7","unstructured":"Early intervention of stem cell transplantation for neonates with hypoxic-ischemic encephalpathy----a preliminary clinical study apps.who.int\/trialsearch\/Trial2.aspx?TrialID=ChiCTR-TNRC-11001591"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0008|cit8","unstructured":"Early intervention of stem cell transplantation for neonates with hypoxic-ischemic encephalpathy----a preliminary clinical study www.chictr.org.cn\/showprojen.aspx?proj=7950"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0009|cit9","unstructured":"Autologous transplantation of cord blood derived stem cells for neonatal hypoxic - ischemic encephalopathy apps.who.int\/trialsearch\/Trial2.aspx?TrialID=ChiCTR-TRC-10000922"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0010|cit10","unstructured":"Cord blood for neonatal hypoxic-ischemic encephalopathy clinicaltrials.gov\/ct2\/show\/record\/NCT00593242?term=NCT00593242&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0011|cit11","unstructured":"Characterization of the cord blood stem cell in situation of neonatal asphyxia (NEOCORD) clinicaltrials.gov\/ct2\/show\/record\/NCT01284673?term=NCT01284673&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0012|cit12","unstructured":"Autologous stem cells in newborns with oxygen deprivation apps.who.int\/trialsearch\/Trial2.aspx?TrialID=NCT01506258"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0013|cit13","unstructured":"Autologous stem cells in newborns with oxygen deprivation clinicaltrials.gov\/ct2\/show\/record\/NCT01506258?term=NCT01506258&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0014|cit14","unstructured":"Autologous cord blood cells for brain injury in term newborns clinicaltrials.gov\/ct2\/show\/NCT01649648?term=NCT01649648&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0015|cit15","unstructured":"A pilot feasibility and safety study of autologous umbilical cord blood cell therapy in infants with neonatal encephalopathy apps.who.int\/trialsearch\/Trial2.aspx?TrialID=JPRN-UMIN000014903"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0016|cit16","unstructured":"A pilot feasibility and safety study of autologous umbilical cord blood cell therapy in infants with neonatal encephalopathy ichgcp.net\/clinical-trials-registry\/NCT02256618"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0017|cit17","unstructured":"Autologous cord blood and human placental derived stem cells in neonates with severe hypoxic-ischemic encephalopathy (HPDSC+HIE) clinicaltrials.gov\/ct2\/show\/record\/NCT02434965?term=NCT02434965&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0018|cit18","unstructured":"Cytokines associated with cord blood cell therapy for neonatal encephalopathy clinicaltrials.gov\/ct2\/show\/record\/NCT02455830?term=NCT02455830&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0019|cit19","unstructured":"A multi-site study of autologous cord blood cells for hypoxic ischemic encephalopathy clinicaltrials.gov\/ct2\/show\/nct02612155"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0020|cit20","unstructured":"Neural progenitor cell and paracrine factors to treat hypoxic ischemic encephalopathy clinicaltrials.gov\/ct2\/show\/NCT02854579?term=NCT02854579&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0021|cit21","unstructured":"Neural progenitor cell and paracrine factors to treat hypoxic ischemic encephalopathy (HIE) apps.who.int\/trialsearch\/Trial2.aspx?TrialID=NCT02854579"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0022|cit22","unstructured":"Neonatal hypoxic ischemic encephalopathy: safety and feasibility study of a curative treatment with autologous cord blood stem cells (NEOSTEM) clinicaltrials.gov\/ct2\/show\/record\/NCT02881970?term=NCT02881970&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0023|cit23","unstructured":"Neonatal hypoxic ischemic encephalopathy: safety and feasibility study of a curative treatment with autologous cord blood stem cells\u00a0NEOSTEM apps.who.int\/trialsearch\/Trial2.aspx?TrialID=NCT02881970"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0024|cit24","unstructured":"Feasibility and safety of umbilical cord blood transfusion in the treatment of neonatal cerebral ischemia and anemia clinicaltrials.gov\/ct2\/show\/record\/NCT03352310?term=NCT03352310&rank=1"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0025|cit25","unstructured":"Study of hCT-MSC in newborn infants with moderate or severe HIE clinicaltrials.gov\/ct2\/show\/record\/NCT03635450?term=NCT03635450&rank=1"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1159\/000444905","article-title":"Stem cells for neonatal brain disorders","volume":"109","author":"Ahn","year":"2016","journal-title":"Neonatology"},{"issue":"12","key":"10.1002\/14651858.CD013202.pub2-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"e0189895","DOI":"10.1371\/journal.pone.0189895","article-title":"Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: a systematic review and meta-analysis of preclinical studies","volume":"12","author":"Archambault","year":"2017","journal-title":"PloS One"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0028|cit28","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1113\/JP271104","article-title":"Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb","volume":"594","author":"Aridas","year":"2016","journal-title":"Journal of Physiology"},{"issue":"7","key":"10.1002\/14651858.CD013202.pub2-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.jcyt.2013.03.005","article-title":"Risk of tumorigenicity in mesenchymal stromal cell-based therapies - bridging scientific observations and regulatory viewpoints","volume":"15","author":"Barkholt","year":"2013","journal-title":"Cytotherapy"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2174\/1574888X11308020005","article-title":"Mesenchymal stem cells derived from Wharton's Jelly of the umbilical cord: biological properties and emerging clinical applications","volume":"8","author":"Batsali","year":"2013","journal-title":"Current Stem Cell Research & Therapy"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0031|cit31","volume-title":"Bayley Scales of Infant Development","author":"Bayley","year":"1993"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0032|cit32","volume-title":"Bayley Scales of Infant and Toddler Development","author":"Bayley","year":"2006"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0033|cit33","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/scrt448","article-title":"Gene markers of cellular aging in human multipotent stromal cells in culture","volume":"5","author":"Bellayr","year":"2014","journal-title":"Stem Cell Research & Therapy"},{"issue":"9","key":"10.1002\/14651858.CD013202.pub2-BIB0034|cit34","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007231.pub2","article-title":"Stem cell transplantation for ischemic stroke","author":"Boncoraglio","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0035|cit35","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1159\/000368770","article-title":"Development of cerebral gray and white matter injury and cerebral inflammation over time after inflammatory perinatal asphyxia","volume":"37","author":"Bonestroo","year":"2015","journal-title":"Developmental Neuroscience"},{"issue":"6","key":"10.1002\/14651858.CD013202.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/STROKEAHA.117.020465","article-title":"Stem cell-based immunomodulation after stroke: effects on brain repair processes","volume":"49","author":"Boshuizen","year":"2018","journal-title":"Stroke"},{"issue":"15","key":"10.1002\/14651858.CD013202.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"11227","DOI":"10.1074\/jbc.M109.086389","article-title":"Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells","volume":"285","author":"Cai","year":"2010","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0038|cit38","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.jpeds.2013.12.011","article-title":"Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial","volume":"164","author":"Chang","year":"2014","journal-title":"Journal of Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"e0115997","DOI":"10.1371\/journal.pone.0115997","article-title":"Neuroprotective\u00a0effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury","volume":"10","author":"Chen","year":"2015","journal-title":"PloS One"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1474-4422(02)00040-6","article-title":"Treatment of neural injury with marrow stromal cells","volume":"1","author":"Chopp","year":"2002","journal-title":"Lancet Neurology"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0041|cit41","unstructured":"Screening, data extraction and management. EPOC Resources for Review Authors, 2017 epoc.cochrane.org\/epoc-specific-resources-review-authors"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"F171","DOI":"10.1136\/fn.86.3.F171","article-title":"Magnetic resonance imaging of the infant brain: anatomical characteristics and clinical significance of punctate lesions","volume":"86","author":"Cornette","year":"2002","journal-title":"Archives of Disease in Childhood. Fetal and Neonatal Edition"},{"issue":"7","key":"10.1002\/14651858.CD013202.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3727\/096368915X688533","article-title":"Optogenetic stimulation of neural grafts enhances neurotransmission and downregulates the inflammatory response in experimental stroke model","volume":"25","author":"Daadi","year":"2016","journal-title":"Cell Transplantation"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1096\/fj.07-9420com","article-title":"Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient cerebral ischemia","volume":"22","author":"David","year":"2008","journal-title":"FASEB Journal"},{"issue":"1 Pt 1","key":"10.1002\/14651858.CD013202.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0002-9378(97)80005-1","article-title":"Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury","volume":"176","author":"Haan","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"10","key":"10.1002\/14651858.CD013202.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn.2017.107","article-title":"The use of brain organoids to investigate neural development and disease","volume":"18","author":"Di Lullo","year":"2017","journal-title":"Nature Reviews. Neuroscience"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1542\/peds.2013-0787","article-title":"Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study","volume":"133","author":"Dingley","year":"2014","journal-title":"Pediatrics"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0048|cit48","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0049|cit49","doi-asserted-by":"publisher","first-page":"e51253","DOI":"10.1371\/journal.pone.0051253","article-title":"Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement","volume":"8","author":"Donega","year":"2013","journal-title":"PloS One"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0050|cit50","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/pr.2015.145","article-title":"Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse","volume":"78","author":"Donega","year":"2015","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"c363","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"7109","key":"10.1002\/14651858.CD013202.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"e1135","DOI":"10.1542\/peds.2009-2268","article-title":"Human recombinant erythropoietin in asphyxia neonatorum: pilot trial","volume":"125","author":"Elmahdy","year":"2010","journal-title":"Pediatrics"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.neulet.2005.01.070","article-title":"Human umbilical cord blood cells express neurotrophic factors","volume":"380","author":"Fan","year":"2005","journal-title":"Neuroscience letters"},{"issue":"6","key":"10.1002\/14651858.CD013202.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/sj.bmt.1705462","article-title":"Has allogeneic stem cell cryopreservation been given the 'cold shoulder'? An analysis of the pros and cons of using frozen versus fresh stem cell products in allogeneic stem cell transplantation","volume":"38","author":"Frey","year":"2006","journal-title":"Bone Marrow Transplantation"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000362206","article-title":"Magnesium is not consistently neuroprotective for perinatal hypoxia-ischemia in term-equivalent models in preclinical studies: a systematic review","volume":"36","author":"Galinsky","year":"2014","journal-title":"Developmental Neuroscience"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0057|cit57","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/978-1-4939-1118-9_6","volume-title":"Perinatal Stem Cells","author":"Garcia","year":"2014"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0058|cit58","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.molmed.2011.10.004","article-title":"The immunomodulatory capacity of mesenchymal stem cells","volume":"18","author":"Gebler","year":"2012","journal-title":"Trends in Molecular Medicine"},{"issue":"11","key":"10.1002\/14651858.CD013202.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1469-8749.1992.tb11407.x","article-title":"When and why do brain cells die?","volume":"34","author":"Gluckman","year":"1992","journal-title":"Developmental Medicine and Child Neurology"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1159\/000232558","article-title":"Erythropoietin sustains cognitive function and brain volume after neonatal stroke","volume":"31","author":"Gonzalez","year":"2009","journal-title":"Developmental Neuroscience"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fped.2016.00114","article-title":"Preterm hypoxic-ischemic encephalopathy","volume":"4","author":"Gopagondanahalli","year":"2016","journal-title":"Frontiers in Pediatrics"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1089\/neu.1995.12.159","article-title":"Hypothermia attenuates the normal increase in interleukin 1 beta RNA and nerve growth factor following traumatic brain injury in the rat","volume":"12","author":"Goss","year":"1995","journal-title":"Journal of Neurotrauma"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0063|cit63","unstructured":"McMaster University (developed by Evidence Prime) GRADEpro GDT 2015"},{"issue":"11","key":"10.1002\/14651858.CD013202.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/sctm.17-0074","article-title":"Long-term recovery after endothelial colony-forming cells or human umbilical cord blood cells administration in a rat model of neonatal hypoxic-ischemic encephalopathy","volume":"6","author":"Grandvuillemin","year":"2017","journal-title":"Stem Cells Translational Medicine"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1203\/00006450-200009000-00014","article-title":"Magnesium sulfate treatment after transient hypoxia-ischemia in the newborn piglet does not protect against cerebral damage","volume":"48","author":"Greenwood","year":"2000","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0066|cit66","volume-title":"The Abilities of Babies: a Study in Mental Measurement","author":"Griffiths","year":"1954"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs","volume":"99","author":"Gunn","year":"1997","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-3782(98)00033-4","article-title":"The 'pharmacology' of neuronal rescue with cerebral hypothermia","volume":"53","author":"Gunn","year":"1998","journal-title":"Early Human Development"},{"issue":"4 Pt 1","key":"10.1002\/14651858.CD013202.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1203\/00006450-199704000-00009","article-title":"Posthypoxic hypothermia in newborn piglets","volume":"41","author":"Haaland","year":"1997","journal-title":"Pediatric Research"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jacc.2016.11.009","article-title":"Randomized comparison of allogeneic versus autologous mesenchymal stem cells for nonischemic dilated cardiomyopathy: POSEIDON-DCM trial","volume":"69","author":"Hare","year":"2017","journal-title":"Journal of the American College of Cardiology"},{"issue":"7414","key":"10.1002\/14651858.CD013202.pub2-BIB0071|cit71","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0072|cit72","doi-asserted-by":"crossref","unstructured":"Higgins JPT Thomas J Chandler J Cumpston M Li T Page MJ Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane, 2019 Available from www.training.cochrane.org\/handbook","DOI":"10.1002\/9781119536604"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/STROKEAHA.107.499822","article-title":"Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia\/ischemia","volume":"39","author":"Hobbs","year":"2008","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.semcdb.2016.02.011","article-title":"Mitochondria in mesenchymal stem cell biology and cell therapy: from cellular differentiation to mitochondrial transfer","volume":"52","author":"Hsu","year":"2016","journal-title":"Seminars in Cell & Developmental Biology"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0075|cit75","unstructured":"Huang L Zhang L Neural stem cell therapies and hypoxic-ischemic brain injury Progress in Neurobiology 10.1016\/j.pneurobio.2018.05.004 29758244"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.2736","article-title":"Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury","volume":"18","author":"Islam","year":"2012","journal-title":"Nature Medicine"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.brainres.2007.03.083","article-title":"\"Therapeutic time window\" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets","volume":"1154","author":"Iwata","year":"2007","journal-title":"Brain Research"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0078|cit78","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1517\/14712598.8.5.569","article-title":"Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies","volume":"8","author":"Iyer","year":"2008","journal-title":"Expert Opinion on Biological Therapy"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0079|cit79","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003311.pub3","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD013202.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/cns.12441","article-title":"NF-kappaB signaling is involved in the effects of intranasally engrafted human neural stem cells on neurofunctional improvements in neonatal rat hypoxic-ischemic encephalopathy","volume":"21","author":"Ji","year":"2015","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0081|cit81","doi-asserted-by":"publisher","first-page":"F162","DOI":"10.1136\/archdischild-2011-300356","article-title":"Long-term neuroprotective effects of\u00a0allopurinol\u00a0after moderate perinatal asphyxia: follow-up of two randomised controlled trials","volume":"97","author":"\u00a0van Bel","year":"2012","journal-title":"Archives of Disease in Childhood. Fetal and Neonatal Edition"},{"issue":"9","key":"10.1002\/14651858.CD013202.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1111\/trf.14192","article-title":"Impact of starting material (fresh versus cryopreserved marrow) on mesenchymal stem cell culture","volume":"57","author":"Kaplan","year":"2017","journal-title":"Transfusion"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.lfs.2016.06.004","article-title":"The therapeutic effect of CD133(+) cells derived from human umbilical cord blood on neonatal mouse hypoxic-ischemic encephalopathy model","volume":"157","author":"Kidani","year":"2016","journal-title":"Life Sciences"},{"issue":"7","key":"10.1002\/14651858.CD013202.pub2-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1177\/0963689718781330","article-title":"Improvement by human oligodendrocyte progenitor cells of neurobehavioral disorders in an experimental model of neonatal periventricular leukomalacia","volume":"27","author":"Kim","year":"2018","journal-title":"Cell Transplantation"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbr.2003.11.002","article-title":"Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in rats","volume":"153","author":"Kumral","year":"2004","journal-title":"Behavioural Brain Research"},{"issue":"10","key":"10.1002\/14651858.CD013202.pub2-BIB0086|cit86","doi-asserted-by":"publisher","first-page":"e47559","DOI":"10.1371\/journal.pone.0047559","article-title":"Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials","volume":"7","author":"Lalu","year":"2012","journal-title":"PloS One"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD013202.pub2-BIB0087|cit87","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/pr.2013.206","article-title":"Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990","volume":"74","author":"Lee","year":"2013","journal-title":"Pediatric Research"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1212\/WNL.59.4.514","article-title":"Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery","volume":"59","author":"Li","year":"2002","journal-title":"Neurology"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0089|cit89","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1542\/peds.2007-1041","article-title":"Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors?","volume":"120","author":"Limperopoulos","year":"2007","journal-title":"Pediatrics"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0090|cit90","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1227\/01.NEU.0000371983.06278.B3","article-title":"Umbilical cord-derived mesenchymal stem cells with forced expression of hepatocyte growth factor enhance remyelination and functional recovery in a rat intracerebral hemorrhage model","volume":"67","author":"Liu","year":"2010","journal-title":"Neurosurgery"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0091|cit91","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mvr.2014.01.008","article-title":"Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia-reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer","volume":"92","author":"Liu","year":"2014","journal-title":"Microvascular Research"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ana.20547","article-title":"Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia","volume":"58","author":"Ma","year":"2005","journal-title":"Annals of Neurology"},{"issue":"10","key":"10.1002\/14651858.CD013202.pub2-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1002\/sctm.17-0065","article-title":"Human embryonic stem cell-derived oligodendrocyte progenitor cells: preclinical efficacy and safety in cervical spinal cord injury","volume":"6","author":"Manley","year":"2017","journal-title":"Stem Cells Translational Medicine"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12974-018-1089-5","article-title":"Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury","volume":"15","author":"McDonald","year":"2018","journal-title":"Journal of Neuroinflammation"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.nbd.2012.12.006","article-title":"Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats","volume":"52","author":"Mine","year":"2013","journal-title":"Neurobiology of Disease"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.semperi.2015.12.002","article-title":"Stem cell-based therapies for the newborn lung and brain: possibilities and challenges","volume":"40","author":"Mitsialis","year":"2016","journal-title":"Seminars in Perinatology"},{"issue":"8","key":"10.1002\/14651858.CD013202.pub2-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1080\/14767058.2017.1405387","article-title":"Upcycling umbilical cords: bridging regenerative medicine with neonatology","volume":"32","author":"Moreira","year":"2019","journal-title":"Journal of Maternal-fetal & Neonatal Medicine"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0098|cit98","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.expneurol.2017.01.001","article-title":"Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic-ischemic brain injury","volume":"290","author":"Mor\u00e1n","year":"2017","journal-title":"Experimental Neurology"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0099|cit99","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1038\/emm.2013.94","article-title":"Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine","volume":"45","author":"Murphy","year":"2013","journal-title":"Experimental & Molecular Medicine"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0100|cit100","first-page":"50","article-title":"Stem cells and their mediators - next generation therapy for bronchopulmonary dysplasia","volume":"2","author":"M\u00f6bius","year":"2015","journal-title":"Frontiers in Medicine"},{"issue":"1-2","key":"10.1002\/14651858.CD013202.pub2-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/pr.2017.260","article-title":"Future perspectives of cell therapy for neonatal hypoxic-ischemic encephalopathy","volume":"83","author":"Nabetani","year":"2018","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0102|cit102","unstructured":"Efficacy study of hypothermia plus magnesium sulphate (MgSO4) in the management of term and near term babies with hypoxic ischemic encephalopathy (MagCool) clinicaltrials.gov\/ct2\/show\/NCT01646619"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0103|cit103","unstructured":"Topiramate in neonates receiving whole body cooling for hypoxic ischemic encephalopathy clinicaltrials.gov\/ct2\/show\/NCT01765218"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0104|cit104","unstructured":"Phase 1 clinical trial of PNEUMOSTEM\u00ae treatment in premature infants with intraventricular hemorrhage clinicaltrials.gov\/ct2\/show\/NCT02274428"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0105|cit105","unstructured":"Prevention of preterm infection by autologous umbilical cord blood mononuclear cells therapy clinicaltrials.gov\/ct2\/show\/NCT02999373"},{"issue":"1-2","key":"10.1002\/14651858.CD013202.pub2-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/pr.2017.261","article-title":"Pediatric brain repair from endogenous neural stem cells of the subventricular zone","volume":"83","author":"Niimi","year":"2018","journal-title":"Pediatric Research"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.expneurol.2006.04.038","article-title":"Neuroprotective effect of topiramate on hypoxic ischemic brain injury in neonatal rats","volume":"201","author":"Noh","year":"2006","journal-title":"Experimental Neurology"},{"issue":"6","key":"10.1002\/14651858.CD013202.pub2-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/stem.1104","article-title":"Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain","volume":"30","author":"Oki","year":"2012","journal-title":"Stem Cells (Dayton, Ohio)"},{"issue":"11","key":"10.1002\/14651858.CD013202.pub2-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.3174\/ajnr.A5350","article-title":"Brain temperature is increased during the first days of life in asphyxiated newborns: developing brain injury despite hypothermia treatment","volume":"38","author":"Owji","year":"2017","journal-title":"AJNR. American Journal of Neuroradiology"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/RNN-2012-120217","article-title":"Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model","volume":"30","author":"Ozyener","year":"2012","journal-title":"Restorative Neurology and Neuroscience"},{"issue":"4 Pt 1","key":"10.1002\/14651858.CD013202.pub2-BIB0111|cit111","first-page":"405","article-title":"Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats","volume":"33","author":"Palmer","year":"1993","journal-title":"Pediatric Research"},{"issue":"6","key":"10.1002\/14651858.CD013202.pub2-BIB0112|cit112","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3727\/096368915X689640","article-title":"Optimal timing of mesenchymal stem cell therapy for neonatal intraventricular hemorrhage","volume":"25","author":"Park","year":"2016","journal-title":"Cell Transplantation"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD013202.pub2-BIB0113|cit113","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.3109\/14767058.2013.796162","article-title":"Low-grade intraventricular hemorrhage: is ultrasound good enough?","volume":"28","author":"Parodi","year":"2015","journal-title":"Journal of Maternal-fetal & Neonatal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/ejh.12140","article-title":"To freeze or not to freeze peripheral blood stem cells prior to allogeneic transplantation from matched related donors","volume":"91","author":"Parody","year":"2013","journal-title":"European Journal of Haematology"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1634\/stemcells.2007-0594","article-title":"Concise review: isolation and characterization of cells from human term placenta: outcome of the first international workshop on placenta derived stem cells","volume":"26","author":"Parolini","year":"2008","journal-title":"Stem Cells"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0116|cit116","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/978-1-4939-1118-9_13","volume-title":"Perinatal Stem Cells","author":"Parolini","year":"2014"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1203\/01.PDR.0000081297.53793.C6","article-title":"Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia","volume":"54","author":"Peeters-Scholte","year":"2003","journal-title":"Pediatric Research"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1203\/00006450-199703000-00024","article-title":"Magnesium sulfate after transient hypoxia-ischemia fails to prevent delayed cerebral energy failure in the newborn piglet","volume":"41","author":"Penrice","year":"1997","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1038\/jp.2010.91","article-title":"Hypothermia for the treatment of infants with hypoxic-ischemic encephalopathy","volume":"30 Suppl","author":"Pfister","year":"2010","journal-title":"Journal of Perinatology"},{"issue":"11","key":"10.1002\/14651858.CD013202.pub2-BIB0120|cit120","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011932.pub2","article-title":"Mesenchymal stem cells for the prevention and treatment of bronchopulmonary dysplasia in preterm infants","author":"Pierro","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4 Pt 2","key":"10.1002\/14651858.CD013202.pub2-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/pr.2011.59","article-title":"Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy","volume":"71","author":"Pimentel-Coelho","year":"2012","journal-title":"Pediatric Research"},{"issue":"Pt 12","key":"10.1002\/14651858.CD013202.pub2-BIB0122|cit122","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1093\/brain\/awt330","article-title":"Rewiring the ischaemic brain with human-induced pluripotent stem cell-derived cortical neurons","volume":"136","author":"Pluchino","year":"2013","journal-title":"Brain"},{"issue":"9","key":"10.1002\/14651858.CD013202.pub2-BIB0123|cit123","doi-asserted-by":"publisher","first-page":"e0138680","DOI":"10.1371\/journal.pone.0138680","article-title":"Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term samples","volume":"10","author":"Podesta","year":"2015","journal-title":"PloS One"},{"issue":"9628","key":"10.1002\/14651858.CD013202.pub2-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0140-6736(08)60837-5","article-title":"Induced hypothermia and fever control for prevention and treatment of neurological injuries","volume":"371","author":"Polderman","year":"2008","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD013202.pub2-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"e0129881","DOI":"10.1371\/journal.pone.0129881","article-title":"Transplantation of induced pluripotent stem cells alleviates cerebral inflammation and neural damage in hemorrhagic stroke","volume":"10","author":"Qin","year":"2015","journal-title":"PloS One"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1440-1789.2007.00792.x","article-title":"Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts","volume":"27","author":"Qu","year":"2007","journal-title":"Neuropathology"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0127|cit127","unstructured":"The Cochrane Collaboration Review Manager Web (RevMan Web) 2019"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0128|cit128","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.pediatrneurol.2014.08.010","article-title":"Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy","volume":"51","author":"Rogers","year":"2014","journal-title":"Pediatric Neurology"},{"issue":"9","key":"10.1002\/14651858.CD013202.pub2-BIB0129|cit129","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013201.pub2","article-title":"Stem cell-based interventions for the prevention and treatment of germinal matrix-intraventricular haemorrhage in preterm infants","author":"Romantsik","year":"2019","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3-4","key":"10.1002\/14651858.CD013202.pub2-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0736-5748(95)00018-C","article-title":"Cytokines in neurodegeneration and repair","volume":"13","author":"Rothwell","year":"1995","journal-title":"International Journal of Developmental Neuroscience"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.brainres.2010.09.078","article-title":"Cord blood administration induces oligodendrocyte survival through alterations in gene expression","volume":"1366","author":"Rowe","year":"2010","journal-title":"Brain Research"},{"issue":"6","key":"10.1002\/14651858.CD013202.pub2-BIB0132|cit132","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00234-010-0700-y","article-title":"Magnetic resonance imaging of white matter diseases of prematurity","volume":"52","author":"Rutherford","year":"2010","journal-title":"Neuroradiology"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0133|cit133","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/978-1-4939-1118-9_25","volume-title":"Perinatal Stem Cells","author":"Sanberg","year":"2014"},{"issue":"10","key":"10.1002\/14651858.CD013202.pub2-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Archives of Neurology"},{"issue":"10","key":"10.1002\/14651858.CD013202.pub2-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1161\/STROKEAHA.108.513978","article-title":"Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury","volume":"39","author":"Schwarting","year":"2008","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0136|cit136","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G Oxman A Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach (updated October 2013). GRADE Working Group, 2013 Available from gdt.guidelinedevelopment.org\/app\/handbook\/handbook.html"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.nbd.2005.05.019","article-title":"Topiramate prevents excitotoxic damage in the newborn rodent brain","volume":"20","author":"Sfaello","year":"2005","journal-title":"Neurobiology of Disease"},{"issue":"4-5","key":"10.1002\/14651858.CD013202.pub2-BIB0138|cit138","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0197-0186(96)00072-1","article-title":"Cytokines and perinatal brain injury","volume":"30","author":"Silverstein","year":"1997","journal-title":"Neurochemistry International"},{"issue":"4 Pt 1","key":"10.1002\/14651858.CD013202.pub2-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1203\/00006450-199604000-00005","article-title":"The effect of prolonged modification of cerebral temperature on outcome after hypoxic-ischemic brain injury in the infant rat","volume":"39","author":"Sirimanne","year":"1996","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0140|cit140","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/978-1-4939-1118-9_31","volume-title":"Perinatal Stem Cells","author":"Taghizadeh","year":"2014"},{"issue":"9","key":"10.1002\/14651858.CD013202.pub2-BIB0141|cit141","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/jp.2013.65","article-title":"Magnesium for newborns with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis","volume":"33","author":"Tagin","year":"2013","journal-title":"Journal of Perinatology"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0142|cit142","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1203\/00006450-199605000-00008","article-title":"Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep","volume":"39","author":"Tan","year":"1996","journal-title":"Pediatric Research"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/00006450-199505000-00019","article-title":"Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet","volume":"37","author":"Thoresen","year":"1995","journal-title":"Pediatric Research"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0144|cit144","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/jcbfm.2008.163","article-title":"Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia","volume":"29","author":"Thoresen","year":"2009","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"Pt 12","key":"10.1002\/14651858.CD013202.pub2-BIB0145|cit145","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1093\/brain\/awt278","article-title":"Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery","volume":"136","author":"Tornero","year":"2013","journal-title":"Brain"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0146|cit146","first-page":"11","article-title":"Stem cell therapies in clinical trials: progress and challenges","volume":"17","author":"Trounson","year":"2015","journal-title":"Stem Cell"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0147|cit147","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2014.01.018","article-title":"Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke","volume":"263","author":"Tsuji","year":"2014","journal-title":"Neuroscience"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0148|cit148","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2009.03.003","article-title":"Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes","volume":"61","author":"Velthoven","year":"2009","journal-title":"Brain Research Reviews"},{"issue":"7","key":"10.1002\/14651858.CD013202.pub2-BIB0149|cit149","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.bbi.2011.03.021","article-title":"Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain","volume":"25","author":"Velthoven","year":"2011","journal-title":"Brain Behavioral Immunology"},{"issue":"4 Pt 2","key":"10.1002\/14651858.CD013202.pub2-BIB0150|cit150","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/pr.2011.64","article-title":"Mesenchymal stem cells as a treatment for neonatal ischemic brain damage","volume":"71","author":"Velthoven","year":"2012","journal-title":"Pediatric Research"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0151|cit151","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.pediatrneurol.2012.10.010","article-title":"Pluripotent possibilities: human umbilical cord blood cell treatment after neonatal brain injury","volume":"48","author":"Verina","year":"2013","journal-title":"Pediatric Neurology"},{"issue":"6","key":"10.1002\/14651858.CD013202.pub2-BIB0152|cit152","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20021067","article-title":"Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis","volume":"198","author":"Villa","year":"2003","journal-title":"Journal of Experimental Medicine"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0153|cit153","doi-asserted-by":"publisher","first-page":"e2213","DOI":"10.1371\/journal.pone.0002213","article-title":"Replicative senescence of mesenchymal stem cells: a continuous and organized process","volume":"3","author":"Wagner","year":"2008","journal-title":"PloS One"},{"issue":"7","key":"10.1002\/14651858.CD013202.pub2-BIB0154|cit154","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/01.STR.0000132196.49028.a4","article-title":"Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats","volume":"35","author":"Wang","year":"2004","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0155|cit155","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainres.2013.04.038","article-title":"Umbilical cord blood cells regulate endogenous neural stem cell proliferation via hedgehog signaling in hypoxic ischemic neonatal rats","volume":"1518","author":"Wang","year":"2013","journal-title":"Brain Research"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0156|cit156","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13041-016-0193-7","article-title":"Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia\/reoxygenation-induced injury via activating the PI3K\/Akt pathway","volume":"9","author":"Wang","year":"2016","journal-title":"Molecular Brain"},{"issue":"7","key":"10.1002\/14651858.CD013202.pub2-BIB0157|cit157","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1002\/sctm.17-0210","article-title":"Concise review: rational use of mesenchymal stem cells in the treatment of ischemic heart disease","volume":"7","author":"Ward","year":"2018","journal-title":"Stem Cells Translational Medicine"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0158|cit158","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/01.STR.22.4.516","article-title":"Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep","volume":"22","author":"Williams","year":"1991","journal-title":"Stroke"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0159|cit159","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.2012-0498","article-title":"Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics","volume":"130","author":"Wu","year":"2012","journal-title":"Pediatrics"},{"issue":"5","key":"10.1002\/14651858.CD013202.pub2-BIB0160|cit160","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1161\/STROKEAHA.111.000719","article-title":"Human umbilical vein endothelial cells protect against hypoxic-ischemic damage in neonatal brain via stromal cell-derived factor 1\/C-X-C chemokine receptor type 4","volume":"44","author":"Wu","year":"2013","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD013202.pub2-BIB0161|cit161","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1016\/j.resuscitation.2015.07.045","article-title":"Part 7: neonatal resuscitation: 2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations","volume":"95","author":"Wyllie","year":"2015","journal-title":"Resuscitation"},{"issue":"1","key":"10.1002\/14651858.CD013202.pub2-BIB0162|cit162","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13287-015-0087-0","article-title":"Transplantation of human oligodendrocyte progenitor cells in an animal model of diffuse traumatic axonal injury: survival and differentiation","volume":"6","author":"Xu","year":"2015","journal-title":"Stem Cell Research & Therapy"},{"issue":"4","key":"10.1002\/14651858.CD013202.pub2-BIB0163|cit163","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1159\/000444905","article-title":"Stem cells for neonatal brain disorders","volume":"109","author":"Yoon","year":"2016","journal-title":"Neonatology"},{"issue":"3","key":"10.1002\/14651858.CD013202.pub2-BIB0164|cit164","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/(SICI)1097-4547(19960801)45:3<282::AID-JNR10>3.0.CO;2-6","article-title":"Neuroprotective effects of hypothermia and U-78517F in cerebral ischemia are due to reducing oxygen-based free radicals: an electron paramagnetic resonance study with gerbils","volume":"45","author":"Zhao","year":"1996","journal-title":"Journal of Neuroscience Research"},{"issue":"2","key":"10.1002\/14651858.CD013202.pub2-BIB0165|cit165","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1542\/peds.2008-3553","article-title":"Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy","volume":"124","author":"Zhu","year":"2009","journal-title":"Pediatrics"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T03:18:37Z","timestamp":1639106317000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD013202.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Neonatal Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":165,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd013202.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]}}}