{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:11:47Z","timestamp":1786975907420,"version":"build-2736575974"},"update-to":[{"DOI":"10.1002\/14651858.cd013634","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000}}],"reference-count":60,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd013634.pub2","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:04:02Z","timestamp":1669791842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgery for chronic arthropathy in people with haemophilia"],"prefix":"10.1002","volume":"2022","author":[{"given":"Brian","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery; National University Health System; Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Haematology-Oncology; National University Cancer Institute; Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas LX","family":"Syn","sequence":"additional","affiliation":[{"name":"Department of Haematology-Oncology; National University Cancer Institute; Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin K","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery; National University Health System; Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng Soo","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine; National University Hospital; Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Lin","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; National University Health System; Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"issue":"2","key":"10.1002\/14651858.CD013634.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/s-0038-1650148","article-title":"Synoviorthesis versus synovectomy in the treatment of recurrent haemophilic haemarthrosis: long-term evaluation","volume":"45","author":"Gamba","year":"1981","journal-title":"Thrombosis and Haemostasis"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD013634.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2516.9.s1.10.x","article-title":"Comparing outcomes of different treatment regimens for severe haemophilia","volume":"9","author":"den Berg","year":"2003","journal-title":"Haemophilia"},{"issue":"8","key":"10.1002\/14651858.CD013634.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1182\/blood-2011-01-327312","article-title":"Unraveling hemophilic arthropathy","volume":"117","author":"Abshire","year":"2011","journal-title":"Blood"},{"issue":"8","key":"10.1002\/14651858.CD013634.pub2-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1177\/1071100720929002","article-title":"Comparison of total ankle arthroplasty and ankle arthrodesis in end-stage hemophilic arthropathy","volume":"41","author":"Ahn","year":"2020","journal-title":"Foot Ankle International"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0005|cit5","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.2147\/JPR.S303305","article-title":"Validity and utility of four pain intensity measures for use in international research","volume":"14","author":"Atisook","year":"2021","journal-title":"Journal of Pain Research"},{"issue":"3","key":"10.1002\/14651858.CD013634.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2516.2009.02001.x","article-title":"Haemophilia in Spain","volume":"15","author":"Aznar","year":"2009","journal-title":"Haemophilia"},{"issue":"3","key":"10.1002\/14651858.CD013634.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/hae.12919","article-title":"Surgical procedures in patients with haemophilic arthropathy of the ankle","volume":"22","author":"Barg","year":"2016","journal-title":"Haemophilia"},{"issue":"2","key":"10.1002\/14651858.CD013634.pub2-BIB0008|cit8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0304-3959(90)90018-9","article-title":"The Faces Pain Scale for the self-assessment of the severity of pain experienced by children: development, initial validation, and preliminary investigation for ratio scale properties","volume":"41","author":"Bieri","year":"1990","journal-title":"Pain"},{"issue":"3","key":"10.1002\/14651858.CD013634.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/hae.12114","article-title":"Ankle fusion in patients with haemophilia","volume":"19","author":"Bluth","year":"2013","journal-title":"Haemophilia"},{"issue":"9371","key":"10.1002\/14651858.CD013634.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0140-6736(03)13405-8","article-title":"Haemophilias A and B","volume":"362","author":"Bolton-Maggs","year":"2003","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD013634.pub2-BIB0011|cit11","doi-asserted-by":"publisher","first-page":"239-55","DOI":"10.1016\/S0885-3924(01)00409-2","article-title":"Pain measurement tools and methods in clinical research in palliative care: recommendations of an expert working group of the European Association of Palliative Care","volume":"23","author":"Caraceni","year":"2002","journal-title":"Journal of Pain Symptom Management"},{"issue":"2","key":"10.1002\/14651858.CD013634.pub2-BIB0012|cit12","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1016\/j.jpain.2013.08.006","article-title":"Comparative responsiveness of verbal and numerical rating scales to measure pain intensity in patients with chronic pain","volume":"14","author":"Chien","year":"2013","journal-title":"Journal of Pain"},{"issue":"1","key":"10.1002\/14651858.CD013634.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1538-7836.2009.03650.x","article-title":"Efficacy and safety of secondary prophylactic vs. on-demand sucrose-formulated recombinant factor VIII treatment in adults with severe hemophilia A: results from a 13-month cross-over study","volume":"8","author":"Collins","year":"2010","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"5","key":"10.1002\/14651858.CD013634.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/00000658-194811000-00002","article-title":"Hemophilia problem of surgical interventions for accompanying diseases: review of the literature and a report of case","volume":"128","author":"Fenniger","year":"1948","journal-title":"Annals of Surgery"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0015|cit15","unstructured":"Deeks JJ Higgins JP Altman DG Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from www.training.cochrane.org\/handbook"},{"issue":"5","key":"10.1002\/14651858.CD013634.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1365-2516.2008.01843.x","article-title":"A survey of adherence to haemophilia therapy in six European countries: results and recommendations","volume":"14","author":"Moerloose","year":"2008","journal-title":"Haemophilia"},{"issue":"2","key":"10.1002\/14651858.CD013634.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/hae.13386","article-title":"Mid- to long-term results of total ankle replacement in patients with haemophilic arthropathy: a 10-year follow-up","volume":"24","author":"Eckers","year":"2017","journal-title":"Haemophilia"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0018|cit18","unstructured":"EndNote Clarivate 2013"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0019|cit19","first-page":"3-6","article-title":"Prophylaxis: musculoskeletal evaluation","volume":"30","author":"Gilbert","year":"1993","journal-title":"Seminars in Hematology"},{"issue":"1","key":"10.1002\/14651858.CD013634.pub2-BIB0020|cit20","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/hae.13631","article-title":"Measurement of joint health in persons with haemophilia: a systematic review of the measurement properties of haemophilia-specific instruments","volume":"25","author":"Gouw","year":"2019","journal-title":"Haemophilia\u00a0"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0021|cit21","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime)"},{"issue":"4","key":"10.1002\/14651858.CD013634.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1538-7836.2011.04214.x","article-title":"A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT study)","volume":"9","author":"Gringeri","year":"2011","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"9","key":"10.1002\/14651858.CD013634.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2106\/00004623-200709000-00002","article-title":"Intermediate and long-term outcomes of total knee arthroplasty and ankle arthrodesis. A systematic review of the literature","volume":"89","author":"Haddad","year":"2007","journal-title":"Journal of Bone and Joint Surgery"},{"issue":"11","key":"10.1002\/14651858.CD013634.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0025|cit25","unstructured":"Higgins JP Altman DG Sterne JA Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.2 (updated June 2017). Cochrane, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0026|cit26","unstructured":"Higgins JP Li T Deeks JJ Chapter 6: Choosing effect measures and computing estimates of effect. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from www.training.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"223-8","DOI":"10.1046\/j.1365-2516.2003.00746.x","article-title":"Third and fourth workshops of the European Paediatric Network for Haemophilia Management","volume":"9","author":"Hill","year":"2003","journal-title":"Haemophilia"},{"issue":"5","key":"10.1002\/14651858.CD013634.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"518-25","DOI":"10.1111\/j.1365-2516.2006.01312.x","article-title":"Hemophilia joint health score reliability study","volume":"12","author":"Hilliard","year":"2006","journal-title":"Haemophilia"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Medical Research Methodology"},{"issue":"8","key":"10.1002\/14651858.CD013634.pub2-BIB0030|cit30","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004449.pub3","article-title":"Recombinant factor VIIa concentrate versus plasma derived concentrates for the treatment of acute bleeding episodes in people with haemophilia and inhibitors","author":"Iorio","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0031|cit31","first-page":"19","volume-title":"Handbook of Pain Assessment","author":"Jensen","year":"2011"},{"issue":"18","key":"10.1002\/14651858.CD013634.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1056\/NEJMoa1104435","article-title":"Anti-inhibitor coagulant complex prophylaxis in hemophilia with inhibitors","volume":"365","author":"Leissinger","year":"2011","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2147\/JBM.S50644","article-title":"Optimal management of hemophilic arthropathy and hematomas","volume":"5","author":"Lobet","year":"2014","journal-title":"Journal of Blood Medicine"},{"issue":"5","key":"10.1002\/14651858.CD013634.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2796.1997.130135000.x","article-title":"Haemophilia prophylaxis in young patients - a long-term follow-up","volume":"241","author":"L\u00f6fqvist","year":"1997","journal-title":"Journal of Internal Medicine"},{"issue":"4","key":"10.1002\/14651858.CD013634.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.5435\/00124635-200407000-00004","article-title":"Hemophilic arthropathy","volume":"12","author":"Luck","year":"2004","journal-title":"Journal of the American Academy of Orthopaedic Surgeons"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"649-57","DOI":"10.1046\/j.1365-2516.2000.00439.x","article-title":"Joint evaluation instruments for children and adults with haemophilia","volume":"6","author":"Manco-Johnson","year":"2000","journal-title":"Haemophilia"},{"issue":"Suppl 4","key":"10.1002\/14651858.CD013634.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1365-2516.2004.00978.x","article-title":"Physical therapy and imaging outcome measures in a hemophilia population treated with factor prophylaxis: current status and future directions","volume":"10","author":"Manco-Johnson","year":"2004","journal-title":"Haemophilia"},{"issue":"6","key":"10.1002\/14651858.CD013634.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/jth.12202","article-title":"Randomized, controlled, parallel-group trial of routine prophylaxis vs. on-demand treatment with sucrose-formulated recombinant factor VIII in adults with severe hemophilia A (SPINART)","volume":"11","author":"Manco-Johnson","year":"2013","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0039|cit39","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2147\/BTT.S252580","article-title":"Recent advances in the treatment of hemophilia: a review","volume":"15","author":"Marchesini","year":"2021","journal-title":"Biologics"},{"issue":"7","key":"10.1002\/14651858.CD013634.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/jcm6070063","article-title":"Pathophysiology of hemophilic arthropathy","volume":"6","author":"Melchiorre","year":"2017","journal-title":"Journal of Clinical Medicine"},{"issue":"13","key":"10.1002\/14651858.CD013634.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1182\/blood-2015-01-528414","article-title":"Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens","volume":"125","author":"Oldenburg","year":"2015","journal-title":"Blood"},{"issue":"3","key":"10.1002\/14651858.CD013634.pub2-BIB0042|cit42","doi-asserted-by":"publisher","first-page":"e1003583","DOI":"10.1371\/journal.pmed.1003583","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"18","author":"Page","year":"2021","journal-title":"PLoS Medicine"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0043|cit43","unstructured":"Page MJ Higgins JP Sterne JA Chapter 13: Assessing risk of bias due to missing results in a synthesis. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from www.training.cochrane.org\/handbook"},{"issue":"24","key":"10.1002\/14651858.CD013634.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8","article-title":"Extracting summary statistics to perform meta-analysis of the published literature for survival endpoints","volume":"17","author":"Parmar","year":"1998","journal-title":"Statistics in Medicine"},{"issue":"149","key":"10.1002\/14651858.CD013634.pub2-BIB0045|cit45","first-page":"153","article-title":"A radiologic classification of hemophilic arthropathy","volume":"June 1","author":"Pettersson","year":"1980","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"4","key":"10.1002\/14651858.CD013634.pub2-BIB0046|cit46","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/j.1365-2516.2006.01292.x","article-title":"The Haemo-QoL Index: developing a short measure for health-related quality of life assessment in children and adolescents with haemophilia","volume":"12","author":"Pollak","year":"2006","journal-title":"Haemophilia"},{"issue":"5","key":"10.1002\/14651858.CD013634.pub2-BIB0047|cit47","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/j.1365-2516.2008.01812.x","article-title":"Cross-cultural development and psychometric evaluation of a patient-reported health-related quality of life questionnaire for adults with haemophilia","volume":"14","author":"Rentz","year":"2008","journal-title":"Haemophilia"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0048|cit48","unstructured":"Review Manager Web (RevMan Web) The Cochrane Collaboration 2022"},{"issue":"4","key":"10.1002\/14651858.CD013634.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2141.2010.08139.x","article-title":"A United Kingdom Haemophilia Centre Doctors' Organization guideline approved by the British Committee for Standards in Haematology: guideline on the use of prophylactic factor VIII concentrate in children and adults with severe haemophilia A","volume":"149","author":"Richards","year":"2010","journal-title":"British Journal of Haematology"},{"issue":"1","key":"10.1002\/14651858.CD013634.pub2-BIB0050|cit50","first-page":"37","article-title":"Musculoskeletal complications of hemophilia","volume":"6","author":"Rodriguez-Merchan","year":"2010","journal-title":"Hospital for Special Surgery Journal"},{"issue":"4","key":"10.1002\/14651858.CD013634.pub2-BIB0051|cit51","doi-asserted-by":"publisher","first-page":"411-8","DOI":"10.1111\/hae.12668","article-title":"Safety of radiation exposure after radiosynovectomy in paediatric patients with haemophilia","volume":"21","author":"Rodriguez-Merchan","year":"2015","journal-title":"Haemophilia"},{"issue":"Suppl 6","key":"10.1002\/14651858.CD013634.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2516.2008.01882.x","article-title":"Haemophilic arthropathy: the importance of the earliest haemarthroses and consequences for treatment","volume":"14","author":"Roosendaal","year":"2008","journal-title":"Haemophilia"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0053|cit53","unstructured":"Sch\u00fcnemann HJ Vist GE Higgins JP Santesso N Deeks JJ Glasziou P Chapter 15: Interpreting results and drawing conclusions. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"issue":"11","key":"10.1002\/14651858.CD013634.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm6110107","article-title":"Knee and ankle arthroplasty in hemophilia","volume":"6","author":"Solimeno","year":"2017","journal-title":"Journal of Clinical Medicine"},{"issue":"2","key":"10.1002\/14651858.CD013634.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/hae.13383","article-title":"Mid-term outcomes and complications of total knee arthroplasty in haemophilic arthropathy: a review of consecutive 131 knees between 2006 and 2015 in a single institute","volume":"24","author":"Song","year":"2017","journal-title":"Haemophilia"},{"issue":"3","key":"10.1002\/14651858.CD013634.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1538-7836.2011.04611.x","article-title":"A randomized comparison of two prophylaxis regimens and a paired comparison of on-demand and prophylaxis treatments in hemophilia A management","volume":"10","author":"Valentino","year":"2012","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"5","key":"10.1002\/14651858.CD013634.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1365-2516.2009.02036.x","article-title":"Factor VIII prophylaxis for adult patients with severe haemophilia A: results of a US survey of attitudes and practices","volume":"15","author":"Walsh","year":"2009","journal-title":"Haemophilia"},{"issue":"6","key":"10.1002\/14651858.CD013634.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Sherbourne","year":"1992","journal-title":"Medical Care"},{"issue":"S6","key":"10.1002\/14651858.CD013634.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hae.14046","article-title":"WFH guidelines for the management of hemophilia, 3rd edition","volume":"26","author":"Srivastava","year":"2020","journal-title":"Haemophilia"},{"key":"10.1002\/14651858.CD013634.pub2-BIB0060|cit60","unstructured":"About bleeding disorders - what are inhibitors? elearning.wfh.org\/elearning-centres\/inhibitors\/"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T13:17:21Z","timestamp":1699190241000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD013634.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Cystic Fibrosis and Genetic Disorders Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":60,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd013634.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]}}}