{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T02:29:02Z","timestamp":1786588142821,"version":"build-2736575974"},"update-to":[{"DOI":"10.1002\/14651858.cd013781","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000}}],"reference-count":105,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd013781.pub2","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T06:51:56Z","timestamp":1732690316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prophylactic use of inotropic agents for the prevention of low cardiac output syndrome and mortality in adults undergoing cardiac surgery"],"prefix":"10.1002","volume":"2024","author":[{"given":"Dwi","family":"Gayatri","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Surgical Intensive Care; University Medicine Halle; Halle (Saale) Germany"},{"name":"Department of Epidemiology; Faculty of Public Health, Universitas Indonesia; Depok Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Tongers","sequence":"additional","affiliation":[{"name":"Cardiology, Angiology and Intensive Care Medicine; University Hospital Halle; Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljupcho","family":"Efremov","sequence":"additional","affiliation":[{"name":"Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), Interdisciplinary Center for Health Sciences; Medical School of the Martin-Luther-University Halle-Wittenberg; Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Mikolajczyk","sequence":"additional","affiliation":[{"name":"Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), Interdisciplinary Center for Health Sciences; Medical School of the Martin-Luther-University Halle-Wittenberg; Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sedding","sequence":"additional","affiliation":[{"name":"Cardiology, Angiology and Intensive Care Medicine; University Hospital Halle; Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schumann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Surgical Intensive Care; University Medicine Halle; Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"10.1002\/14651858.CD013781.pub2-BIB0001|cit1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2174\/2589645801913010059","article-title":"Levosimendan versus milrinone in the management of impaired left ventricular function in patients undergoing coronary artery bypass graft surgery","volume":"13","author":"Amin","year":"2019","journal-title":"Open Anesthesia Journal"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0002|cit2","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1093\/icvts\/ivw213","article-title":"Effectiveness of prophylactic levosimendan in patients with impaired left ventricular function undergoing coronary artery bypass grafting: a randomized pilot study","volume":"23","author":"Anastasiadis","year":"2016","journal-title":"Interactive Cardiovascular and Thoracic Surgery"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0003|cit3","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1053\/j.jvca.2013.09.004","article-title":"Levosimendan improves renal outcome in cardiac surgery: a randomized trial","volume":"28","author":"Baysal","year":"2014","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2017.9973","article-title":"Effect of levosimendan on low cardiac output syndrome in patients with low ejection fraction undergoing coronary artery bypass grafting with cardiopulmonary bypass: the LICORN randomized clinical trial","volume":"318","author":"Cholley","year":"2017","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0005|cit5","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1213\/01.ane.0000256863.92050.d3","article-title":"The effects of levosimendan in cardiac surgery patients with poor left ventricular function","volume":"104","author":"De Hert","year":"2007","journal-title":"Anesthesia and Analgesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0006|cit6","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1007\/s12630-016-0709-8","article-title":"A multicentre randomized-controlled trial of inhaled milrinone in high-risk cardiac surgical patients","volume":"63","author":"Denault","year":"2016","journal-title":"Canadian Journal of Anesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0007|cit7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.4103\/aca.ACA_178_17","article-title":"Prophylactic preoperative levosimendan for off-pump coronary artery bypass grafting in patients with left ventricular dysfunction: single-centered randomized prospective study","volume":"21","author":"Desai","year":"2018","journal-title":"Annals of Cardiac Anaesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0008|cit8","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1177\/0300060513516293","article-title":"Influence of levosimendan on organ dysfunction in patients with severely reduced left ventricular function undergoing cardiac surgery","volume":"42","author":"Erb","year":"2014","journal-title":"Journal of International Medical Research"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0009|cit9","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.athoracsur.2008.10.029","article-title":"Levosimendan facilitates weaning from cardiopulmonary bypass in patients undergoing coronary artery bypass grafting with impaired left ventricular function","volume":"87","author":"Riksson","year":"2009","journal-title":"Cardiothoracic Anesthesiology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0010|cit10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.5830\/CVJA-2013-047","article-title":"Effectiveness of prophylactic levosimendan in high-risk valve surgery patients","volume":"24","author":"Ersoy","year":"2013","journal-title":"Cardiovascular Journal of Africa"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0011|cit11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4103\/0971-9784.105363","article-title":"A comparison of hemodynamic effects of levosimendan and dobutamine in patients undergoing mitral valve repair \/ replacement for severe mitral stenosis","volume":"16","author":"Gandham","year":"2013","journal-title":"Annals of Cardiac Anaesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0012|cit12","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/j.0886-0440.2004.04044.x","article-title":"Should we give prophylactic renal-dose dopamine after coronary artery bypass surgery?","volume":"19","author":"Gatot","year":"2004","journal-title":"Journal of Cardiac Surgery"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0013|cit13","first-page":"681","article-title":"Effect of milrinone on short term outcome of patients with myocardial dysfunction undergoing off-pump coronary artery bypass graft: a randomized clinical trial","volume":"51","author":"Hadadzadeh","year":"2013","journal-title":"Acta Medica Iranica"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0014|cit14","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.12092\/j.issn.1009-2501.2020.09.010","article-title":"Application of levosimendan in severe patients after cardiac surgery","volume":"25","author":"Hu","year":"2020","journal-title":"Chinese Journal of Clinical Pharmacology and Therapeutics"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0015|cit15","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1053\/j.jvca.2008.01.024","article-title":"Levosimendan in aortic valve surgery: cardiac performance and recovery","volume":"22","author":"J\u00e4rvel\u00e4","year":"2008","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0016|cit16","doi-asserted-by":"publisher","first-page":"92","DOI":"10.4097\/kjae.2010.59.2.92","article-title":"The effect of milrinone infusion on right ventricular function during coronary anastomosis and early outcomes in patients undergoing off-pump coronary artery bypass surgery","volume":"59","author":"Jo","year":"2010","journal-title":"Korean Journal of Anesthesiology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0017|cit17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/aas.12425","article-title":"Effects of levosimendan in patients with left ventricular hypertrophy undergoing aortic valve replacement","volume":"59","author":"Juhl-Olsen","year":"2015","journal-title":"Acta Anaesthesiologica Scandinavica"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"200","DOI":"10.4103\/aca.ACA_195_16","article-title":"Comparison of levosimendan versus dobutamine in patients with moderate to severe left ventricular dysfunction undergoing off-pump coronary artery bypass grafting: a randomized prospective study","volume":"20","author":"Kandasamy","year":"2017","journal-title":"Annals of Cardiac Anaesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/00000539-200201000-00005","article-title":"The efficacy of preemptive milrinone or amrinone therapy in patients undergoing coronary artery bypass grafting","volume":"94","author":"Kikura","year":"2002","journal-title":"Anesthesia and Analgesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0020|cit20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4103\/0971-9784.109737","article-title":"Effect of levosimendan on hemodynamic changes in patients undergoing off-pump coronary artery bypass grafting: a randomized controlled study","volume":"16","author":"Kodalli","year":"2013","journal-title":"Annals of Cardiac Anaesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0021|cit21","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1097\/CCM.0b013e3182227b97","article-title":"Levosimendan reduces heart failure after cardiac surgery: a prospective, randomized, placebo-controlled trial","volume":"39","author":"Lahtinen","year":"2011","journal-title":"Cri\u00edtical Care Medicine"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0022|cit22","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/bja\/aeq402","article-title":"Preoperative levosimendan infusion in combined aortic valve and coronary bypass surgery","volume":"106","author":"Leppikangas","year":"2011","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0023|cit23","first-page":"125","article-title":"Preoperative levosimendan decreases mortality and the development of low cardiac output in high-risk patients with severe left ventricular dysfunction undergoing coronary artery bypass grafting with cardiopulmonary bypass","volume":"17","author":"Levin","year":"2012","journal-title":"Experimental and Clinical Cardiology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0024|cit24","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1056\/NEJMoa1616218","article-title":"Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery","volume":"376","author":"Mehta","year":"2017","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0025|cit25","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1053\/j.jvca.2016.01.015","article-title":"Comparative effect of levosimendan and milrinone in cardiac surgery patients with pulmonary hypertension and left ventricular dysfunction","volume":"30","author":"Mishra","year":"2016","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/0253-7613.125161","article-title":"Study of levosimendan during off-pump coronary artery bypass grafting in patients with LV dysfunction: a double-blind randomized study","volume":"46","author":"Shah","year":"2014","journal-title":"Indian Journal of Pharmacology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1177\/0218492313499352","article-title":"Preoperative levosimendan in ischemic mitral valve repair","volume":"22","author":"Sharma","year":"2014","journal-title":"Asian Cardiovascular and Thoracic Annals"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0028|cit28","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/bja\/ael082","article-title":"Preconditioning effects of levosimendan in coronary artery bypass grafting - a pilot study","volume":"96","author":"Tritapepe","year":"2006","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1093\/bja\/aen367","article-title":"Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery","volume":"102","author":"Tritapepe","year":"2009","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0030|cit30","first-page":"389","article-title":"Hemodynamic effects of levosimendan following cardiac surgery","volume":"52","author":"Alvarez","year":"2005","journal-title":"Revista Espa\u00f1ola de Anestesiolog\u00eda y Reanimaci\u00f3n"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0031|cit31","doi-asserted-by":"publisher","first-page":"E230","DOI":"10.1532\/hsf.1426","article-title":"Levosimendan use increases cardiac performance after coronary artery bypass grafting in end-stage renal disease patients","volume":"19","author":"Atalay","year":"2016","journal-title":"Heart Surgery Forum"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0032|cit32","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1097\/00005344-200412000-00013","article-title":"Levosimendan in off-pump coronary artery bypass: a four-times masked controlled study","volume":"44","author":"Barisin","year":"2004","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0033|cit33","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1111\/aas.13170","article-title":"Inotropic and lusitropic effects of levosimendan and milrinone assessed by strain echocardiography - a randomised trial","volume":"62","author":"Fredholm","year":"2018","journal-title":"Acta Anaestesiologica Scandinavica"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0034|cit34","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/aas.13486","article-title":"Levosimendan or milrinone for right ventricular inotropic treatment? - A secondary analysis of a randomized trial","volume":"64","author":"Fredholm","year":"2020","journal-title":"Acta Anaestesiologica Scandinavica"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0035|cit35","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/BF01683138","article-title":"Haemodynamic effects of dopamine, epinephrine and orciprenaline (Alupent) in patients early after cardiac surgery","volume":"4","author":"Gattiker","year":"1978","journal-title":"Intensive Care Medicine"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0036|cit36","doi-asserted-by":"publisher","first-page":"679","DOI":"10.2459\/JCM.0000000000000537","article-title":"Effects of levosimendan in patients with severe functional mitral regurgitation undergoing MitraClip implantation","volume":"18","author":"Giannini","year":"2017","journal-title":"Journal of Cardiovascular Medicine"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0037|cit37","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1253\/jcj.63.605","article-title":"Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone","volume":"63","author":"Hamada","year":"1999","journal-title":"Japanese Circulation Journal"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0038|cit38","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/00005344-199203000-00001","article-title":"Comparison of enoximone and piroximone in patients after mitral valve operation: a prospective and controlled clinical study","volume":"19","author":"Hausen","year":"1992","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0039|cit39","first-page":"73","article-title":"Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: a randomized controlled trial","volume":"17","author":"Jebeli","year":"2010","journal-title":"Cardiology Journal"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0040|cit40","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1177\/0218492320972891","article-title":"Pre-bypass levosimendan in ventricular dysfunction-effect on right ventricle","volume":"29","author":"Kumar","year":"2021","journal-title":"Asian Cardiovascular and Thoracic Annals"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0041|cit41","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1053\/euhj.1997.0806","article-title":"Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting","volume":"19","author":"Lilleberg","year":"1998","journal-title":"European Heart Journal"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0042|cit42","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/00005344-199908000-00007","article-title":"Levosimendan enhances cardiac performance after cardiopulmonary bypass: a prospective, randomized placebo-controlled trial","volume":"34","author":"Nijhawan","year":"1999","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0043|cit43","first-page":"17","article-title":"The effectiveness of enoximone in patients with serious left ventricular dysfunction submitted for aorto-coronary bypass","volume":"63","author":"Oppizzi","year":"1997","journal-title":"Minerva Anesthesiologica"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0044|cit44","doi-asserted-by":"publisher","first-page":"E313","DOI":"10.1532\/HSF98.2014415","article-title":"Evaluation of myocardial contractility determination with tissue tracking echocardiography after levosimendan infusion in patients with poor left ventricular function and hemodynamics","volume":"17","author":"Sahin","year":"2014","journal-title":"Heart Surgery Forum"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0045|cit45","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4103\/0971-9784.173020","article-title":"Comparison of levosimendan and nitroglycerine in patients undergoing coronary artery bypass graft surgery","volume":"19","author":"Sahu","year":"2016","journal-title":"Annals of Cardiac Anaesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0046|cit46","first-page":"15","article-title":"Haemodynamic effects and comparison of enoximone, dobutamine and dopamine following mitral valve surgery","volume":"10","author":"Tarr","year":"1993","journal-title":"European Journal of Anaesthesiology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0047|cit47","doi-asserted-by":"publisher","first-page":"138","DOI":"10.2174\/1874192401610010138","article-title":"The effects of levosimendan and sodium nitroprusside combination on left ventricular functions after surgical ventricular reconstruction in coronary artery bypass grafting patients","volume":"10","author":"Temizturk","year":"2016","journal-title":"Open Cardiovascular Medicine Journal"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0048|cit48","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1016\/j.jtcvs.2019.06.020","article-title":"Levosimendan in patients with reduced left ventricular function undergoing isolated coronary or valve surgery","volume":"159","author":"Diepen","year":"2020","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0049|cit49","first-page":"574","article-title":"The effect of enoximone and dobutamine on hemodynamic performance after open heart surgery. A clinical comparison","volume":"31","author":"Zeplin","year":"1990","journal-title":"Journal of Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0050|cit50","unstructured":"Intermittent repeated administration of levosimendan improves outcomes in patients undergoing cardiopulmonary bypass surgery https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=ChiCTR2100046169"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0051|cit51","unstructured":"Spanish randomized clinical trial to compare levosimendan versus placebo in postoperative cardiac surgery (SPARTANS) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04179604"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0052|cit52","unstructured":"Levosimendan in patients with impaired right ventricular function undergoing cardiac surgery https:\/\/clinicaltrials.gov\/ct2\/show\/record\/NCT05063370"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0053|cit53","unstructured":"Levosimendan versus placebo before tricuspid valve surgery in patients with right ventricular dysfunction (LEONARD) https:\/\/clinicaltrials.gov\/ct2\/show\/record\/NCT05233202?view=record"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0054|cit54","first-page":"Doc12","article-title":"S3 guidelines for intensive care in cardiac surgery patients","volume":"8","author":"Carl","year":"2010","journal-title":"German Medical Science"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s13054-017-1848-1","article-title":"Effect of levosimendan on prognosis in adult patients undergoing cardiac surgery","volume":"21","author":"Chen","year":"2017","journal-title":"Critical Care"},{"issue":"6","key":"10.1002\/14651858.CD013781.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/jocs.13716","article-title":"Effects of levosimendan on mortality in patients undergoing cardiac surgery","volume":"33","author":"Chen","year":"2018","journal-title":"Journal of Cardiac Surgery"},{"issue":"6","key":"10.1002\/14651858.CD013781.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2017.9973","article-title":"Effect of levosimendan on low cardiac output syndrome in patients with low ejection fraction undergoing coronary artery bypass grafting with cardiopulmonary bypass","volume":"318","author":"Cholley","year":"2017","journal-title":"JAMA"},{"issue":"3","key":"10.1002\/14651858.CD013781.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1016\/j.hlc.2018.02.018","article-title":"Levosimendan following cardiac surgery","volume":"28","author":"Conte","year":"2019","journal-title":"Heart Lung and Circulation"},{"issue":"2","key":"10.1002\/14651858.CD013781.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/aca.ACA_178_17","article-title":"Prophylactic preoperative levosimendan for off-pump coronary artery bypass grafting in patients with left ventricular dysfunction","volume":"21","author":"Desai","year":"2018","journal-title":"Annals of Cardiac Anaesthesia"},{"issue":"5","key":"10.1002\/14651858.CD013781.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.athoracsur.2017.11.027","article-title":"Meta-analysis of trials on prophylactic use of levosimendan in patients undergoing cardiac surgery","volume":"105","author":"Elbadawi","year":"2018","journal-title":"Annals of Thoracic Surgery"},{"issue":"5","key":"10.1002\/14651858.CD013781.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00101-018-0433-6","article-title":"S3-Leitlinie zur intensivmedizinischen versorgung herzchirurgischer patienten","volume":"67","author":"Habicher","year":"2018","journal-title":"Der Anaesthesist"},{"issue":"6","key":"10.1002\/14651858.CD013781.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1053\/j.jvca.2013.03.027","article-title":"Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis","volume":"27","author":"Harrison","year":"2013","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0063|cit63","unstructured":"Higgins JP Altman DG Sterne JA Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). Cochrane, 2011 Available from training.cochrane.org\/handbook\/archive\/v5.1\/"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0064|cit64","unstructured":"Higgins JP Li T Deeks JJ Chapter 6: Choosing effect measures and computing estimates of effect. In: Higgins JP, Thomas J, Chandler J, Cumpson M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.0 (updated July 2019). Cochrane, 2019 Available from training.cochrane.org\/handbook\/archive\/v6"},{"issue":"8","key":"10.1002\/14651858.CD013781.pub2-BIB0065|cit65","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011312.pub3","article-title":"Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease","author":"Hummel","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD013781.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/CCM.0b013e318232962a","article-title":"Effects of levosimendan on mortality and hospitalization: a meta-analysis of randomized controlled studies","volume":"40","author":"Landoni","year":"2012","journal-title":"Critical Care Medicine"},{"issue":"21","key":"10.1002\/14651858.CD013781.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMoa1616325","article-title":"Levosimendan for hemodynamic support after cardiac surgery","volume":"376","author":"Landoni","year":"2017","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD013781.pub2-BIB0068|cit68","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1007\/s00134-017-4927-5","article-title":"Effects of levosimendan for perioperative cardiovascular dysfunction in patients receiving cardiac surgery","volume":"43","author":"Lee","year":"2017","journal-title":"Intensive Care Medicine"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0069|cit69","unstructured":"Lefebvre C Glanville J Briscoe S Littlewood A Marshall C Chapter 4: Searching for and selecting studies. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.0 (updated July 2019). Cochrane, 2019 Available from training.cochrane.org\/handbook\/archive\/v6"},{"issue":"7","key":"10.1002\/14651858.CD013781.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLOS Medicine"},{"issue":"2","key":"10.1002\/14651858.CD013781.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1053\/j.jvca.2012.08.005","article-title":"Meta-analysis of randomized trials of effect of milrinone on mortality in cardiac surgery: an update","volume":"27","author":"Majure","year":"2013","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"issue":"21","key":"10.1002\/14651858.CD013781.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1056\/NEJMoa1616218","article-title":"Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery","volume":"376","author":"Mehta","year":"2017","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jclinane.2018.08.019","article-title":"Levosimendan use in patients with preoperative low ejection fraction undergoing cardiac surgery: a systematic review with meta-analysis and trial sequential analysis","volume":"52","author":"Ng","year":"2019","journal-title":"Journal of Clinical Anesthesia"},{"issue":"3","key":"10.1002\/14651858.CD013781.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/CJ9.0000000000000121","article-title":"Perioperative use of levosimendan in patients undergoing cardiac surgery: systematic review and meta-analysis","volume":"47","author":"Oliveros","year":"2019","journal-title":"Colombian Journal of Anesthesiology"},{"issue":"5","key":"10.1002\/14651858.CD013781.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/jcpt.12067","article-title":"Pharmacology of levosimendan","volume":"38","author":"Pathak","year":"2013","journal-title":"Journal of Clinical Pharmacy and Therapeutics"},{"issue":"12","key":"10.1002\/14651858.CD013781.pub2-BIB0076|cit76","first-page":"1167","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"69","author":"Ponikowski","year":"2016","journal-title":"Revista Espanola de Cardiologia (English ed.)"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijcard.2017.10.077","article-title":"Perioperative levosimendan in cardiac surgery: a systematic review with meta-analysis and trial sequential analysis","volume":"251","author":"Putzu","year":"2018","journal-title":"International Journal of Cardiology"},{"issue":"4","key":"10.1002\/14651858.CD013781.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.medin.2012.01.016","article-title":"Resumen del documento de consenso: \"Gu\u00edas de pr\u00e1ctica cl\u00ednica para el manejo del s\u00edndrome de bajo gasto cardiaco en el postoperatorio de cirug\u00eda cardiaca\"","volume":"36","author":"P\u00e9rez Vela","year":"2012","journal-title":"Medicina Intensiva"},{"issue":"1","key":"10.1002\/14651858.CD013781.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/FJC.0000000000000584","article-title":"Perioperative use of levosimendan improves clinical outcomes in patients after cardiac surgery: a systematic review and meta-analysis","volume":"72","author":"Qiang","year":"2018","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0080|cit80","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1186\/s12872-020-01598-8","article-title":"The effect of milrinone on mortality in adult patients who underwent CABG surgery: a systematic review of randomized clinical trials with a meta-analysis and trialsequential analysis","volume":"20","author":"Peng","year":"2020","journal-title":"BMC Cardiovascular Disorders"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0081|cit81","unstructured":"Review Manager 5 (RevMan 5) The Cochrane Collaboration 2020"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"663673","DOI":"10.1053\/j.jvca.2018.08.208","article-title":"Intravenous and inhaled milrinone in adult cardiac surgery patients: a pairwise and network meta-analysis","volume":"33","author":"Rong","year":"2019","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"issue":"1","key":"10.1002\/14651858.CD013781.pub2-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s13054-017-1849-0","article-title":"Levosimendan for patients with severely reduced left ventricular systolic function and\/or low cardiac output syndrome undergoing cardiac surgery","volume":"21","author":"Sanfilippo","year":"2017","journal-title":"Critical Care"},{"issue":"1","key":"10.1002\/14651858.CD013781.pub2-BIB0084|cit84","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009669.pub3","article-title":"Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome","author":"Schumann","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0085|cit85","unstructured":"Sch\u00fcnemann HJ Higgins JP Vist GE Glasziou P Akl EA Skoetz N Chapter 14: Completing 'Summary of findings' tables and grading the certainty of the evidence. In: Higgins JP, Thomas J, Chandler J, Cumpston MS, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.0 (updated July 2019). Cochrane, 2019 Available from training.cochrane.org\/handbook\/archive\/v6"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0086|cit86","unstructured":"Stata StataCorp 2017"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"e343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD013781.pub2-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/icvts\/ivy133","article-title":"Levosimendan versus placebo in cardiac surgery: a systematic review and meta-analysis","volume":"27","author":"Tena","year":"2018","journal-title":"Interactive Cardiovascular and Thoracic Surgery"},{"issue":"6","key":"10.1002\/14651858.CD013781.pub2-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1053\/j.jvca.2016.07.027","article-title":"Impact of milrinone administration in adult cardiac surgery patients: updated meta-analysis","volume":"30","author":"Ushio","year":"2016","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"issue":"16","key":"10.1002\/14651858.CD013781.pub2-BIB0090|cit90","first-page":"e232","article-title":"Contemporary management of cardiogenic shock","volume":"136","author":"Diepen","year":"2017","journal-title":"Circulation"},{"issue":"6","key":"10.1002\/14651858.CD013781.pub2-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.jtcvs.2019.06.020","article-title":"Levosimendan in patients with reduced left ventricular function undergoing isolated coronary or valve surgery","volume":"159","author":"Diepen","year":"2020","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"issue":"20","key":"10.1002\/14651858.CD013781.pub2-BIB0092|cit92","first-page":"31293","article-title":"Cardiac surgery in low- and middle-income countries: a state-of-the-art review","volume":"6","author":"Vervoort","year":"2020","journal-title":"Annals of Thoracic Surgery"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0093|cit93","first-page":"7563083","article-title":"Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery: an update meta-analysis and trial sequential analysis","volume":"2018","author":"Wang","year":"2018","journal-title":"BioMed Research International"},{"issue":"1","key":"10.1002\/14651858.CD013781.pub2-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s13054-019-2704-2","article-title":"Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery","volume":"23","author":"Wang","year":"2019","journal-title":"Critical Care"},{"issue":"4","key":"10.1002\/14651858.CD013781.pub2-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00540-019-02643-3","article-title":"The efficacy and safety of prophylactic use of levosimendan on patients undergoing coronary artery bypass graft","volume":"33","author":"Wang","year":"2019","journal-title":"Journal of Anesthesia"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0096|cit96","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3389\/fped.2020.00456","article-title":"Effect of prophylactic levosimendan on all-cause mortality in pediatric patients undergoing cardiac surgery\u2014an updated systematic review and meta-analysis","volume":"8","author":"Wang","year":"2020","journal-title":"Frontiers in Pediatrics"},{"issue":"5","key":"10.1002\/14651858.CD013781.pub2-BIB0097|cit97","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1055\/s-0039-3400496","article-title":"Levosimendan reduces mortality and low cardiac output syndrome in cardiac surgery","volume":"68","author":"Weber","year":"2020","journal-title":"Thoracic and Cardiovascular Surgeon"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0098|cit98","doi-asserted-by":"publisher","first-page":"7775","DOI":"10.1038\/s41598-018-26206-w","article-title":"Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery: a meta-analysisand trial sequential analysis of randomized trials","volume":"8","author":"Xing","year":"2018","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1002\/14651858.CD013781.pub2-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s40256-019-00372-2","article-title":"Impact of perioperative levosimendan administration on risk of bleeding after cardiac surgery","volume":"20","author":"Yan","year":"2020","journal-title":"American Journal of Cardiovascular Drugs"},{"key":"10.1002\/14651858.CD013781.pub2-BIB0100|cit100","first-page":"53","article-title":"Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials","volume":"10","author":"You","year":"2016","journal-title":"Drug Design, Development and Therapy"},{"issue":"4","key":"10.1002\/14651858.CD013781.pub2-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1053\/j.jvca.2008.11.013","article-title":"Levosimendan reduces cardiac troponin release after cardiac surgery: a meta-analysis of randomized controlled studies","volume":"23","author":"Zangrillo","year":"2009","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"issue":"1","key":"10.1002\/14651858.CD013781.pub2-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1053\/j.jvca.2011.06.022","article-title":"Milrinone and mortality in adult cardiac surgery: a meta-analysis","volume":"26","author":"Zangrillo","year":"2012","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"issue":"6","key":"10.1002\/14651858.CD013781.pub2-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/icvts\/ivy017","article-title":"Effect of levosimendan on clinical outcomes in adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials","volume":"26","author":"Zhou","year":"2018","journal-title":"Interactive Cardiovascular and Thoracic Surgery"},{"issue":"3","key":"10.1002\/14651858.CD013781.pub2-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.accpm.2018.08.005","article-title":"Levosimendan in patients with low cardiac output syndrome undergoing cardiac surgery","volume":"38","author":"Zhu","year":"2019","journal-title":"Anaesthesia, Critical Care and Pain Medicine"},{"issue":"11","key":"10.1002\/14651858.CD013781.pub2-BIB0105|cit105","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013781","article-title":"Prophylactic use of inotropic agents for the prevention of low cardiac output syndrome and mortality in adults undergoing cardiac surgery","author":"Tongers","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T02:17:36Z","timestamp":1786587456000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD013781.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Central Editorial Service","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":105,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd013781.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]}}}