{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T19:47:22Z","timestamp":1782330442945,"version":"3.54.5"},"update-to":[{"DOI":"10.1002\/14651858.cd014592","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000}}],"reference-count":132,"publisher":"Wiley","issue":"7","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd014592.pub2","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T07:31:25Z","timestamp":1689060685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women"],"prefix":"10.1002","volume":"2023","author":[{"given":"Annika","family":"Taithongchai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology; King's College Hospital; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenie E","family":"Johnson","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute; Newcastle University; Newcastle upon Tyne UK"},{"name":"NIHR Innovation Observatory; Newcastle University; Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharif I","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology; Royal Sussex County Hospital; Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Barron-Millar","sequence":"additional","affiliation":[{"name":"Evidence Synthesis Group, Population Health Sciences Institute; Newcastle University; Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Kernohan","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute; Newcastle University; Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranee","family":"Thakar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology; Croydon University Hospital NHS Trust; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0001|cit1","first-page":"26","article-title":"Ultrastructural aspects of the postmenopausal endometrium after oral or transdermal estrogen administration","volume":"28","author":"Baracat","year":"2001","journal-title":"Clinical and Experimental Obstetrics and Gynecology"},{"issue":"8","key":"10.1002\/14651858.CD014592.pub2-BIB0002|cit2","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1097\/GME.0000000000000851","article-title":"Effects of ultralow topic estriol dose on vaginal health and quality of life in postmenopausal women who underwent surgical treatment for pelvic organ prolapse","volume":"24","author":"Caruso","year":"2017","journal-title":"Menopause"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0003|cit3","unstructured":"Vaginal estriol before and vaginal surgery for prolapse (VSaE) clinicaltrials.gov\/show\/NCT02906111"},{"issue":"7","key":"10.1002\/14651858.CD014592.pub2-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1007\/s00192-021-04821-y","article-title":"Effect of vaginal estrogen in postmenopausal women using vaginal pessary for pelvic organ prolapse treatment: a randomized controlled trial","volume":"33","author":"Chiengthong","year":"2022","journal-title":"International Urogynecology Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0005|cit5","unstructured":"Effect of vaginal estriol 0.03 mg with Lactobacillus acidophilus on incidence of bacterial vaginosis in patient using pessary for treatment of pelvic organ prolapse thaiclinicaltrials.org\/show\/TCTR20180329001"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0006|cit6","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1007\/s00192-020-04555-3","article-title":"Estrogen use on complications for women treating pelvic organ prolapse with vaginal pessaries (ESTRO-PESS)-a randomized clinical trial (Abstract 007)","volume":"31","author":"Coelho","year":"2020","journal-title":"International Urogynecology Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0007|cit7","unstructured":"Impact of cream vaginal use on complications in women using vaginal ring in treatment of genital prolapse: a randomized clinical trial [Impacto do uso do creme vaginal nas complica\u00e7\u00f5es em mulheres usu\u00e1rias de anel vaginais no tratamento do prolapso genital: ensaio cl\u00ednico randomizado] ensaiosclinicos.gov.br\/rg\/RBR-23sqxz"},{"issue":"3","key":"10.1002\/14651858.CD014592.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0378-5122(92)90208-L","article-title":"Preoperative treatment with oestradiol in women scheduled for vaginal operation for genital prolapse. A randomised, double-blind trial","volume":"15","author":"Felding","year":"1992","journal-title":"Maturitas"},{"issue":"2","key":"10.1002\/14651858.CD014592.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000292320","article-title":"Clinical effects of preoperative oestradiol treatment before vaginal repair operation. A double-blind, randomized trial","volume":"40","author":"Mikkelsen","year":"1995","journal-title":"Gynecologic and Obstetric Investigation"},{"issue":"6","key":"10.1002\/14651858.CD014592.pub2-BIB0010|cit10","first-page":"887","article-title":"Optimizing post-operative healing following vaginal reconstructive surgery: a triple arm randomized clinical trial of an estradiol-releasing vaginal ring (Abstract 55)","volume":"29","author":"Karp","year":"2010","journal-title":"Neurourology and Urodynamics"},{"issue":"4","key":"10.1002\/14651858.CD014592.pub2-BIB0011|cit11","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/SPV.0b013e31825e6401","article-title":"A randomized clinical trial of the impact of local estrogen on postoperative tissue quality after vaginal reconstructive surgery","volume":"18","author":"Karp","year":"2012","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0012|cit12","unstructured":"Preoperative locally applied oestrogen in postmenopausal women with pelvic organ prolapse: influence on subjective and objective parameters www.clinicaltrialsregister.eu\/ctr-search\/trial\/2016-000410-30\/results"},{"issue":"7","key":"10.1002\/14651858.CD014592.pub2-BIB0013|cit13","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.jsxm.2022.04.007","article-title":"Sexual function in postmenopausal women with symptomatic pelvic organ prolapse treated either with locally applied estrogen or placebo: results of a double-masked, placebo-controlled, multicenter trial","volume":"19","author":"Marschalek","year":"2022","journal-title":"Journal of Sexual Medicine"},{"issue":"11","key":"10.1002\/14651858.CD014592.pub2-BIB0014|cit14","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.3390\/jcm10112531","article-title":"Surgical assessment of tissue quality during pelvic organ prolapse repair in postmenopausal women pre-treated either with locally applied estrogen or placebo: results of a double-masked, placebo-controlled, multicenter trial","volume":"10","author":"Marschalek","year":"2021","journal-title":"Journal of Clinical Medicine"},{"issue":"13","key":"10.1002\/14651858.CD014592.pub2-BIB0015|cit15","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1111\/1471-0528.16894","article-title":"Does preoperative locally applied estrogen treatment facilitate prolapse-associated symptoms in postmenopausal women with symptomatic pelvic organ prolapse? A randomised controlled double-masked, placebo-controlled, multicentre study","volume":"128","author":"Marschalek","year":"2021","journal-title":"BJOG"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0016|cit16","unstructured":"Preoperative oestrogen in postmenopausal women with pelvic organ prolapse clinicaltrials.gov\/show\/NCT03779633"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/13697137.2010.500010","article-title":"Uterine prolapse: evaluation of glycosaminoglycans in postmenopausal women after estrogen therapy","volume":"14","author":"Nunes","year":"2011","journal-title":"Climacteric"},{"issue":"Suppl 5","key":"10.1002\/14651858.CD014592.pub2-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1097\/SPV.0b013e3182a5ddf0","article-title":"Local estrogen treatment prior to pelvic reconstructive surgery decreases collagenases and elastases in the vaginal wall: a double-blind randomized controlled study in postmenopausal women with prolapse (Abstract 06)","volume":"19","author":"Good","year":"2013","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"issue":"Suppl 5","key":"10.1002\/14651858.CD014592.pub2-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1097\/SPV.0b013e3182a5ddf0","article-title":"Patient compliance & safety with use of preoperative local estrogen treatment in postmenopausal women with prolapse: Analysis from a double-blind randomized controlled study (Abstract 15)","volume":"19","author":"Good","year":"2013","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0020|cit20","unstructured":"Effect of preoperative estrogen treatment on connective tissues of the pelvic floor (PET) clinicaltrials.gov\/show\/NCT01778985"},{"issue":"10","key":"10.1002\/14651858.CD014592.pub2-BIB0021|cit21","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1210\/jc.2014-1216","article-title":"Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial","volume":"99","author":"Rahn","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"Suppl 5","key":"10.1002\/14651858.CD014592.pub2-BIB0022|cit22","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1097\/SPV.0b013e3182a5ddf0","article-title":"Effects of preoperative local estrogen treatment on connective tissues of the vaginal wall in postmenopausal women with prolapse: a double-blind randomized controlled study (Abstract 05)","volume":"19","author":"Rahn","year":"2013","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"issue":"6","key":"10.1002\/14651858.CD014592.pub2-BIB0023|cit23","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1089\/rej.2012.1337","article-title":"Estrogen replacement therapy improves pulmonary function in postmenopausal women with genital prolapse","volume":"15","author":"Stipic","year":"2012","journal-title":"Rejuvenation Research"},{"issue":"7","key":"10.1002\/14651858.CD014592.pub2-BIB0024|cit24","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/GME.0000000000000614","article-title":"Effects of preoperative vaginal estrogen therapy for the incidence of mesh complication after pelvic organ prolapse surgery in postmenopausal women: is it helpful or a myth? A 1-year randomized controlled trial","volume":"23","author":"Sun","year":"2016","journal-title":"Menopause"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0025|cit25","unstructured":"Zhu L Sun Z A Randomized, controlled trial of intravaginal promestriene in women with a risk of mesh exposure associated with transvaginal implantation for pelvic organ prolapse chictr.org.cn\/showproj.aspx?proj=6079"},{"issue":"7","key":"10.1002\/14651858.CD014592.pub2-BIB0026|cit26","first-page":"757","article-title":"Effect of local estrogen cream on vaginal health after pessary use for prolapsed pelvic organ: a randomized controlled trial","volume":"99","author":"Tontivuthikul","year":"2016","journal-title":"Journal of the Medical Association of Thailand"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0027|cit27","unstructured":"The effects of local vaginal estrogen in postmenopausal women with pelvic organ prolapse clinicaltrials.gov\/ct2\/show\/NCT00803335"},{"issue":"Suppl 3","key":"10.1002\/14651858.CD014592.pub2-BIB0028|cit28","doi-asserted-by":"publisher","first-page":"S1839","DOI":"10.1007\/s00192-011-1521-1","article-title":"Administration of vaginal estrogen in women with vaginal atrophy prior to prolapse surgery: an assessment of quality of life outcomes and medication adherence (Abstract 286)","volume":"22","author":"Vaccaro","year":"2011","journal-title":"International Urogynecology Journal"},{"issue":"8 Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"S151","DOI":"10.1097\/SPV.0b013e31826abf55","article-title":"Impact of preoperative vaginal estrogen on patient quality of life measures: a randomized controlled trial (Abstract 120)","volume":"18","author":"Vaccaro","year":"2012","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0030|cit30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/SPV.0b013e318278cc40","article-title":"Histologic and cytologic effects of vaginal estrogen in women with pelvic organ prolapse: a randomized controlled trial","volume":"19","author":"Vaccaro","year":"2013","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"issue":"2 Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0031|cit31","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1097\/SPV.0b013e31824bf52d","article-title":"The effects of vaginal estrogen in women with pelvic organ prolapse: a randomized controlled trial (Abstract 02)","volume":"18","author":"Vaccaro","year":"2012","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0032|cit32","unstructured":"Local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery (LOTUS) www.clinicaltrialsregister.eu\/ctr-search\/trial\/2014-000179-18\/results"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0033|cit33","unstructured":"Local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery isrctn.com\/ISRCTN46661996"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0034|cit34","unstructured":"Middleton L Email to: E Johnson"},{"issue":"9","key":"10.1002\/14651858.CD014592.pub2-BIB0035|cit35","doi-asserted-by":"publisher","first-page":"e025141","DOI":"10.1136\/bmjopen-2018-025141","article-title":"Randomised controlled trial to investigate the effectiveness of local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery (LOTUS): a pilot study to assess feasibility of a large multicentre trial","volume":"10","author":"Verghese","year":"2020","journal-title":"BMJ Open"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0036|cit36","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1007\/s00192-018-3752-x","article-title":"A randomised controlled trial to investigate the effectiveness of local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery (LOTUS)-a pilot study to assess feasibility of a large multi-centre trial (Abstract 026)","volume":"29","author":"Verghese","year":"2018","journal-title":"International Urogynecology Journal"},{"issue":"2","key":"10.1002\/14651858.CD014592.pub2-BIB0037|cit37","first-page":"281","article-title":"Sexual function in women with urinary incontinence and pelvic organ prolapse","volume":"99","author":"Barber","year":"2002","journal-title":"Obstetrics and Gynecology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0038|cit38","doi-asserted-by":"publisher","first-page":"S168","DOI":"10.1007\/s00192-019-04125-2","article-title":"Comparison of vaginal moisturizers with ultralow dose estriol & lactobacilluls acidophilus vaginaltablets in pelvic organ prolapse women who were treated with vaginal pessary: a randomized controlled trial (Abstract 144)","volume":"30","author":"Chinthakanan","year":"2019","journal-title":"International Urogynecology Journal"},{"issue":"5 Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0039|cit39","doi-asserted-by":"publisher","first-page":"S142","DOI":"10.1097\/SPV.0000000000000767","article-title":"Comparison of vaginal moisturizers with ultra-low dose estriol & lactobacilluls acidophilus vaginal tablets in pelvic organ prolapse women whowere treated with vaginal pessary: a randomized controlled trial (Scientific Salon 144)","volume":"25","author":"Chinthakanan","year":"2019","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0040|cit40","unstructured":"Chinthakanan O Comparison of vaginal moisturizers with ultra-low dose estriol & Lactobacillus acidophilus vaginal tablets in pelvic organ prolapse women who were treated with vaginal pessary: a randomized controlled trial thaiclinicaltrials.org\/show\/TCTR20160621001"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0041|cit41","unstructured":"Vaginal estrogen with pessary treatment clinicaltrials.gov\/show\/NCT01843166"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0042|cit42","first-page":"732","article-title":"Effect of puerarin on vaginal connective tissue in patients with pelvic organ prolapse","volume":"10","author":"Jiang","year":"2017","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0043|cit43","unstructured":"Vaginal creams to reduce vaginal erosion in pessary users clinicaltrials.gov\/show\/NCT02316249"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0044|cit44","unstructured":"Vaginal estrogen and pelvic floor physical therapy in women with symptomatic mild prolapse clinicaltrials.gov\/show\/NCT01648751"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0045|cit45","unstructured":"Comparison of vaginal laser therapy to vaginal estrogen therapy (VeLVET) clinicaltrials.gov\/ct2\/show\/NCT02691936"},{"issue":"5 Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0046|cit46","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1097\/SPV.0000000000000617","article-title":"Comparison of vaginal laser therapy to vaginal estrogen therapy (VELVET) for women with genitourinary syndrome of menopause (GSM) (Abstract 62)","volume":"24","author":"Paraiso","year":"2018","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0047|cit47","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/GME.0000000000001416","article-title":"A randomized clinical trial comparing vaginal laser therapy to vaginal estrogen therapy in women with genitourinary syndrome of menopause: the VeLVET Trial","volume":"27","author":"Paraiso","year":"2020","journal-title":"Menopause"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0048|cit48","first-page":"S97","article-title":"Pelvic-floor: new therapeutic approach (Abstract IDP66)","volume":"11","author":"Valente","year":"2000","journal-title":"International Urogynecological Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0049|cit49","unstructured":"Vaginal estrogens comparative trial on pelvic organ prolapse patients clinicaltrials.gov\/show\/NCT03032848"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0050|cit50","unstructured":"Pinhat E RE: Study query: Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Email to: E Johnson"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0051|cit51","volume-title":"Estudo Comparativo De Cremes Estrog\u00eanicos Em Pacientes Com Prolapso Genital [Masters thesis] [Comparative Study of Estrogen Cream in Patients with Genital Prolapse. For information only, English title translated via Google Translate\u2122]","author":"Pinhat","year":"2017"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1067\/mob.2003.374","article-title":"Short-term urogenital effects of raloxifene, tamoxifen, and estrogen","volume":"189","author":"Vardy","year":"2003","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0053|cit53","first-page":"S33","article-title":"Short term urogenital effects of raloxifene, tamoxifen, and estrogen (Abstract 15)","volume":"12","author":"Vardy","year":"2001","journal-title":"International Urogynecology Journal"},{"issue":"Suppl 6","key":"10.1002\/14651858.CD014592.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jmig.2014.08.170","article-title":"Could vaginal estrogen application prior to surgery reduce mesh exposure in transvaginal pelvic floor reconstruction with mesh? A 2-year randomized controlled trial (Abstract 156)","volume":"21","author":"Zhu","year":"2014","journal-title":"Journal of Minimally Invasive Gynecology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0055|cit55","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1007\/s00192-014-2429-3","article-title":"Could vaginal estrogen application prior to surgery reduce mesh exposure in transvaginal pelvic floor reconstruction with mesh? A 2-year randomized controlled trial (Abstract PP 46)","volume":"25","author":"Zhu","year":"2014","journal-title":"International Urogynecology Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0056|cit56","unstructured":"Investigation to minimize prolapse recurrence of the vagina using estrogen (IMPROVE) clinicaltrials.gov\/show\/NCT02431897"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0057|cit57","doi-asserted-by":"publisher","first-page":"e227","DOI":"10.1097\/SPV.0000000000000899","article-title":"Design of a randomized clinical trial of perioperative vaginal estrogen versus placebo with transvaginal native tissue apical prolapse repair (investigation to minimize prolapse repair of the vagina using estrogen: IMPROVE)","volume":"27","author":"Rahn","year":"2021","journal-title":"Female Pelvic Medicine and Reconstructive Surgery"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0058|cit58","unstructured":"Research into effectiveness and costs concerning the use of (vaginally administered) oestrogen before and after vaginal prolapse surgery, in women after menopause [Onderzoek naar de effectiviteit en kosten van vaginale oestrogeencr\u00e8me bij vrouwen na de menopauze die een verzakkingsoperatie ondergaan] www.clinicaltrialsregister.eu\/ctr-search\/trial\/2017-003144-21\/NL"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0059|cit59","unstructured":"Research into effectiveness and costs concerning the use of oestrogen before and after vaginal prolapse surgery in women after menopause trialregister.nl\/trial\/6853 [Dutch Trial Register (NTR) is undergoing redevelopment, information available via trialsearch.who.int\/Trial2.aspx?TrialID=NTR7031]"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0060|cit60","unstructured":"Hormonal status on blood flow and tissue in pelvic organ prolapse clinicaltrials.gov\/show\/NCT01886794"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0061|cit61","unstructured":"The effect of intravaginal conjugated estrogen on ring pessary use for pelvic organ prolapse: a multicenter randomized, double- blind, placebo controlled, clinical trial chictr.org.cn\/hvshowproject.aspx?id=32555"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0062|cit62","unstructured":"The effect of intra-vaginal conjugated estrogen cream on ring pessary use for pelvic organ prolapse clinicaltrials.gov\/show\/NCT04393194"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0063|cit63","unstructured":"Aluko P Graybill E Craig D Henderson C Drummond M Wilson EC on behalf of the Campbell and Cochrane Economics Methods Group Chapter 20: Economic evidence. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"issue":"4","key":"10.1002\/14651858.CD014592.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/nau.20041","article-title":"ICIQ: a brief and robust measure for evaluating the symptoms and impact of urinary incontinence","volume":"23","author":"Avery","year":"2004","journal-title":"Neurourology and Urodynamics"},{"issue":"2","key":"10.1002\/14651858.CD014592.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00192-008-0742-4","article-title":"Australian pelvic floor questionnaire: a validated interviewer-administered pelvic floor questionnaire for routine clinic and research","volume":"20","author":"Baessler","year":"2009","journal-title":"International Urogynecology Journal"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00192-018-3724-1","article-title":"The minimal important difference of the Australian pelvic floor questionnaire","volume":"30","author":"Baessler","year":"2019","journal-title":"International Urogynaecology Journal"},{"issue":"6","key":"10.1002\/14651858.CD014592.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1067\/mob.2001.118659","article-title":"Psychometric evaluation of 2 comprehensive condition-specific quality of life instruments for women with pelvic floor disorders","volume":"185","author":"Barber","year":"2001","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD014592.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"580.e1","DOI":"10.1016\/j.ajog.2009.02.007","article-title":"The minimum important differences for the urinary scales of the pelvic floor distress inventory and pelvic floor impact questionnaire","volume":"200","author":"Barber","year":"2009","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"8","key":"10.1002\/14651858.CD014592.pub2-BIB0069|cit69","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s00192-019-04070-0","article-title":"Effectiveness of hormones in postmenopausal pelvic floor dysfunction \u2013 International Urogynecological Association research and development \u2013 committee opinion","volume":"31","author":"Bodner-Adler","year":"2020","journal-title":"International Urogynecology Journal"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ajog.2003.12.027","article-title":"A scored form of the Bristol female lower urinary tract symptoms questionnaire: data from a randomized controlled trial of surgery for women with stress incontinence","volume":"191","author":"Brookes","year":"2004","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"11","key":"10.1002\/14651858.CD014592.pub2-BIB0071|cit71","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004010.pub4","article-title":"Pessaries (mechanical devices) for pelvic organ prolapse in women","author":"Bugge","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0002-9378(96)70243-0","article-title":"The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction","volume":"175","author":"Bump","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0073|cit73","doi-asserted-by":"publisher","first-page":"l6890","DOI":"10.1136\/bmj.l6890","article-title":"Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline","volume":"368","author":"Campbell","year":"2020","journal-title":"BMJ"},{"issue":"10","key":"10.1002\/14651858.CD014592.pub2-BIB0074|cit74","doi-asserted-by":"publisher","DOI":"10.1002\/14651858","article-title":"Oestrogen therapy for urinary incontinence in post-menopausal women","author":"Cody","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD014592.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s00192-017-3373-9","article-title":"Validation of a single summary score for the prolapse\/incontinence sexual questionnaire \u2013 IUGA revised (PISQ-IR)","volume":"28","author":"Constantine","year":"2017","journal-title":"International Urogynecology Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0076|cit76","unstructured":"Centre for Reviews and Dissemination (CRD) CRD databases: search strategies. 2015 Available at crd.york.ac.uk\/crdweb\/"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0077|cit77","unstructured":"Deeks JJ Higgins JP Altman DG Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from www.training.cochrane.org\/handbook"},{"issue":"4","key":"10.1002\/14651858.CD014592.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/00003081-199312000-00015","article-title":"Anatomy and biomechanics of genital prolapse","volume":"36","author":"DeLancey","year":"1993","journal-title":"Clinical Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1067\/mob.2002.125733","article-title":"Fascial and muscular abnormalities in women with urethral hypermobility and anterior vaginal wall prolapse","volume":"187","author":"Delancey","year":"2002","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"10","key":"10.1002\/14651858.CD014592.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00192-008-0695-7","article-title":"The aetiology of prolapse","volume":"19","author":"Dietz","year":"2008","journal-title":"International Urogynecology Journal"},{"issue":"3","key":"10.1002\/14651858.CD014592.pub2-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s00192-004-1225-x","article-title":"P-QOL: a validated questionnaire to assess the symptoms and quality of life of women with urogenital prolapse","volume":"16","author":"Digesu","year":"2005","journal-title":"International Urogynecology Journal"},{"issue":"7109","key":"10.1002\/14651858.CD014592.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0083|cit83","unstructured":"EndNote Clarivate Analytics 2018"},{"issue":"3","key":"10.1002\/14651858.CD014592.pub2-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00914935","article-title":"The quality of life questionnaire: a multidimensional measure","volume":"13","author":"Evans","year":"1985","journal-title":"American Journal of Community Psychology"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0085|cit85","volume-title":"Quality of Life Inventory Handbook: A Guide for Laypersons, Clients, and Coaches","author":"Frisch","year":"2009"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0086|cit86","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime)"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1471-0528.2008.01903.x","article-title":"Psychometric properties of the pelvic organ prolapse symptom score","volume":"116","author":"Hagen","year":"2009","journal-title":"BJOG"},{"issue":"6","key":"10.1002\/14651858.CD014592.pub2-BIB0088|cit88","first-page":"1055","article-title":"Further properties of the pelvic organ prolapse symptom score: minimally important change and test-retest reliability (Abstract 175)","volume":"29","author":"Hagen","year":"2010","journal-title":"Neurourology and Urodynamics"},{"issue":"12","key":"10.1002\/14651858.CD014592.pub2-BIB0089|cit89","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003882.pub4","article-title":"Conservative prevention and management of pelvic organ prolapse in women","author":"Hagen","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD014592.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1008815005736","article-title":"The assessment of quality of life (AQoL) instrument: a psychometric measure of health-related quality of life","volume":"8","author":"Hawthorne","year":"1999","journal-title":"Quality of Life Research"},{"issue":"2","key":"10.1002\/14651858.CD014592.pub2-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1467-842X.2005.tb00063.x","article-title":"Population norms and meaningful differences for the Assessment of Quality of Life (AQoL) measure","volume":"29","author":"Hawthorne","year":"2005","journal-title":"Australian and New Zealand Journal of Public Health"},{"issue":"2","key":"10.1002\/14651858.CD014592.pub2-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00192-015-2932-1","article-title":"An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for pelvic organ prolapse (POP)","volume":"27","author":"Haylen","year":"2016","journal-title":"International Urogynecology Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0093|cit93","unstructured":"Higgins JP Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from training.cochrane.org\/handbook\/archive\/v5.1\/"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0094|cit94","unstructured":"Higgins JP Thomas J Chandler J Cumpston M Li T Page MJ Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0095|cit95","unstructured":"Higgins JP Eldridge S Li T Chapter 23: Including variants on randomized trials. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from training.cochrane.org\/handbook"},{"issue":"5","key":"10.1002\/14651858.CD014592.pub2-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00540019","article-title":"Development of a new type of global quality of life scale, and comparison of performance and preference for 12 global scales","volume":"5","author":"Hyland","year":"1996","journal-title":"Quality of Life Research"},{"issue":"9","key":"10.1002\/14651858.CD014592.pub2-BIB0097|cit97","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007063.pub2","article-title":"Oestrogens for treatment or prevention of pelvic organ prolapse in postmenopausal women","author":"Ismail","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD014592.pub2-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.ajog.2006.01.060","article-title":"Women seeking treatment for advanced pelvic organ prolapse have decreased body image and quality of life","volume":"194","author":"Jelovsek","year":"2006","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"12","key":"10.1002\/14651858.CD014592.pub2-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1111\/j.1471-0528.1997.tb11006.x","article-title":"A new questionnaire to assess the quality of life of urinary incontinent women","volume":"104","author":"Kelleher","year":"1997","journal-title":"BJOG"},{"issue":"6","key":"10.1002\/14651858.CD014592.pub2-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1471-0528.2004.00129.x","article-title":"How much is enough and who says so? The case of the King's Health Questionnaire and overactive bladder","volume":"111","author":"Kelleher","year":"2004","journal-title":"BJOG"},{"issue":"8","key":"10.1002\/14651858.CD014592.pub2-BIB0101|cit101","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001500.pub3","article-title":"Local oestrogen for vaginal atrophy in postmenopausal women","author":"Lethaby","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.urology.2019.08.004","article-title":"The minimum clinically important difference of the international consultation on incontinence questionnaires (ICIQ-UI SF and ICIQ-LUTSqol)","volume":"133","author":"Lim","year":"2019","journal-title":"Urology"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2147\/IJWH.S52555","article-title":"Reviewing the options for local estrogen treatment of vaginal atrophy","volume":"6","author":"Lindahl","year":"2014","journal-title":"International Journal of Women's Health"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00192-017-3395-3","article-title":"Reoperation for pelvic organ prolapse: a Danish cohort study with 15\u201320 years' follow-up","volume":"29","author":"L\u00f8wenstein","year":"2018","journal-title":"International Urogynecology Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0105|cit105","first-page":"1855","volume-title":"Incontinence: 6th International Consultation on Incontinence","author":"Maher","year":"2017"},{"issue":"3","key":"10.1002\/14651858.CD014592.pub2-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/13697137.2018.1551348","article-title":"Surgical management of pelvic organ prolapse","volume":"22","author":"Maher","year":"2019","journal-title":"Climacteric"},{"issue":"10","key":"10.1002\/14651858.CD014592.pub2-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00192-014-2342-9","article-title":"The minimum important difference for the pelvic organ prolapse-urinary incontinence sexual function questionnaire","volume":"25","author":"Mamik","year":"2014","journal-title":"International Urogynecology Journal"},{"issue":"4","key":"10.1002\/14651858.CD014592.pub2-BIB0108|cit108","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"Journal of the National Cancer Institute"},{"issue":"3","key":"10.1002\/14651858.CD014592.pub2-BIB0109|cit109","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012975","article-title":"Surgery for women with posterior compartment prolapse","author":"Mowat","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2147\/IJWH.S158913","article-title":"Current treatment options for postmenopausal vaginal atrophy","volume":"10","author":"Naumova","year":"2018","journal-title":"International Journal of Women's Health"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0111|cit111","unstructured":"National Institute for Health and Care Excellence (NICE) Urinary incontinence and pelvic organ prolapse in women: management NICE guideline [NG123]. Published: 2 April 2019; last updated: 24 June 2019 Available at nice.org.uk\/guidance\/ng123"},{"issue":"3 Pt 1","key":"10.1002\/14651858.CD014592.pub2-BIB0112|cit112","first-page":"355","article-title":"The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society","volume":"14","author":"North American Menopause Society","year":"2007","journal-title":"Menopause"},{"issue":"4","key":"10.1002\/14651858.CD014592.pub2-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0029-7844(97)00058-6","article-title":"Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence","volume":"89","author":"Olsen","year":"1997","journal-title":"Obstetrics and Gynecology"},{"issue":"6","key":"10.1002\/14651858.CD014592.pub2-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1471-0528.2006.00938.x","article-title":"Development and psychometric evaluation of the ICIQ vaginal symptoms questionnaire: the ICIQ-VS","volume":"113","author":"Price","year":"2006","journal-title":"BJOG"},{"issue":"7","key":"10.1002\/14651858.CD014592.pub2-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jsxm.2021.04.005","article-title":"Minimal clinically important difference (MCID) for the pelvic organ prolapse-urinary incontinence sexual function questionnaire \u2013 IUGA revised (PISQ-IR)","volume":"18","author":"Pruijssers","year":"2021","journal-title":"Journal of Sexual Medicine"},{"issue":"2","key":"10.1002\/14651858.CD014592.pub2-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1471-0528.2005.00820.x","article-title":"Computer interviewing in urogynaecology: concept, development and psychometric testing of an electronic pelvic floor assessment questionnaire in primary and secondary care","volume":"113","author":"Radley","year":"2006","journal-title":"BJOG"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00192-014-2554-z","article-title":"Vaginal estrogen use in postmenopausal women with pelvic floor disorders: systematic review and practice guidelines","volume":"26","author":"Rahn","year":"2015","journal-title":"International Urogynecology Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0118|cit118","unstructured":"Review Manager 5 (RevMan 5) Nordic Cochrane Centre, The Cochrane Collaboration 2020"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0119|cit119","first-page":"361","volume-title":"Incontinence: 6th International Consultation on Incontinence","author":"Salvatore","year":"2017"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0120|cit120","unstructured":"Sch\u00fcnemann HJ Higgins JP Vist GE Glasziou P Akl EA Skoetz N Chapter 14: Completing 'Summary of findings' tables and grading the certainty of the evidence. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/cs1010147","article-title":"Effects of hormone replacement therapy and high-impact physical exercise on skeletal muscle in post-menopausal women: a randomized placebo-controlled study","volume":"101","author":"Sipil\u00e4","year":"2001","journal-title":"Clinical Science"},{"issue":"5","key":"10.1002\/14651858.CD014592.pub2-BIB0122|cit122","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00192-009-1069-5","article-title":"Validation of the patient global impression of improvement (PGI-I) for urogenital prolapse","volume":"21","author":"Srikrishna","year":"2010","journal-title":"International Urogynecology Journal"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD014592.pub2-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/13697130903007389","article-title":"Type and route of estrogen administration","volume":"12","author":"Stevenson","year":"2009","journal-title":"Climacteric"},{"issue":"2","key":"10.1002\/14651858.CD014592.pub2-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejogrb.2009.03.004","article-title":"Rate, type, and cost of pelvic organ prolapse surgery in Germany, France, and England","volume":"144","author":"Subramanian","year":"2009","journal-title":"European Journal of Obstetrics, Gynecology and Reproductive Biology"},{"issue":"6","key":"10.1002\/14651858.CD014592.pub2-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/uog.13222","article-title":"Use of a visual analog scale for evaluation of bother from pelvic organ prolapse","volume":"43","author":"Ulrich","year":"2014","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"issue":"11","key":"10.1002\/14651858.CD014592.pub2-BIB0127|cit127","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00192-015-2695-8","article-title":"Risk factors for pelvic organ prolapse and its recurrence: a systematic review","volume":"26","author":"Vergeldt","year":"2015","journal-title":"International Urogynecology Journal"},{"issue":"9","key":"10.1002\/14651858.CD014592.pub2-BIB0128|cit128","doi-asserted-by":"crossref","first-page":"e025141","DOI":"10.1136\/bmjopen-2018-025141","article-title":"Randomised controlled trial to investigate the effectiveness of local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery (LOTUS): a pilot study to assess feasibility of a large multicentre trial","volume":"10","author":"Verghese","year":"2020","journal-title":"BMJ Open"},{"key":"10.1002\/14651858.CD014592.pub2-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/s12905-021-01587-9","article-title":"Cost-effectiveness of perioperative vaginally administered estrogen in postmenopausal women undergoing prolapse surgery (EVA trial): study protocol for a multicenter double-blind randomized placebo-controlled trial","volume":"21","author":"Vodegel","year":"2021","journal-title":"BMC Women's Health"},{"issue":"9","key":"10.1002\/14651858.CD014592.pub2-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"e0136265","DOI":"10.1371\/journal.pone.0136265","article-title":"Local oestrogen for pelvic floor disorders: a systematic review","volume":"10","author":"Weber","year":"2015","journal-title":"PLOS One"},{"issue":"1","key":"10.1002\/14651858.CD014592.pub2-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/13697130500042490","article-title":"Vaginal rugae: measurement and significance","volume":"8","author":"Whiteside","year":"2005","journal-title":"Climacteric"},{"issue":"5","key":"10.1002\/14651858.CD014592.pub2-BIB0132|cit132","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014592","article-title":"Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women","author":"Taithongchai","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T16:02:39Z","timestamp":1765900959000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD014592.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Incontinence Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,7,11]]},"references-count":132,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd014592.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,11]]}}}