{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:29:36Z","timestamp":1789500576373,"version":"build-2803163510"},"update-to":[{"DOI":"10.1002\/14651858.cd015038","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000}}],"reference-count":82,"publisher":"Wiley","issue":"4","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd015038.pub2","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T11:35:22Z","timestamp":1714390522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Appendectomy versus antibiotic treatment for acute appendicitis"],"prefix":"10.1002","volume":"2024","author":[{"given":"Brett","family":"Doleman","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthesia; Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham; Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siv","family":"Fonnes","sequence":"additional","affiliation":[{"name":"Center for Perioperative Optimization, Department of Surgery; Herlev Hospital; Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon N","family":"Lund","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, School of Medicine; University of Nottingham; Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Boyd-Carson","sequence":"additional","affiliation":[{"name":"Department of Surgery; Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham; Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Javanmard-Emamghissi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences; University of Nottingham; Nottinghamshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Moug","sequence":"additional","affiliation":[{"name":"Department of Surgery; Royal Alexandra Hospital; Paisley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Hollyman","sequence":"additional","affiliation":[{"name":"Department of General Surgery; Taunton and Somerset NHS Foundation Trust; Taunton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Tierney","sequence":"additional","affiliation":[{"name":"Department of Surgery; Royal Derby Hospital; Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samson","family":"Tou","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery; Royal Derby Hospital; Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthesia; Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham; Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"issue":"8","key":"10.1002\/14651858.CD015038.pub2-BIB0001|cit1","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.53350\/pjmhs211581927","article-title":"Comparison of conservative versus surgical management of acute appendicitis in terms of hospital stay","volume":"15","author":"Ahmad","year":"2021","journal-title":"Pakistan Journal of Medical and Health Sciences"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0002|cit2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2482-13-3","article-title":"A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis (APPAC trial)","volume":"13","author":"Paajanen","year":"2013","journal-title":"BMC Surgery"},{"issue":"23","key":"10.1002\/14651858.CD015038.pub2-BIB0003|cit3","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1001\/jama.2015.6154","article-title":"Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial","volume":"313","author":"Salminen","year":"2015","journal-title":"JAMA"},{"issue":"12","key":"10.1002\/14651858.CD015038.pub2-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1001\/jama.2018.13201","article-title":"Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial","volume":"320","author":"Salminen","year":"2018","journal-title":"JAMA"},{"issue":"10","key":"10.1002\/14651858.CD015038.pub2-BIB0005|cit5","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1002\/bjs.10575","article-title":"Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial","volume":"104","author":"Sippola","year":"2017","journal-title":"British Journal of Surgery"},{"issue":"4","key":"10.1002\/14651858.CD015038.pub2-BIB0006|cit6","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1001\/jamasurg.2019.6028","article-title":"Quality of life and patient satisfaction at 7-year follow-up of antibiotic therapy vs appendectomy for uncomplicated acute appendicitis: a secondary analysis of a randomized clinical trial","volume":"155","author":"Sippola","year":"2020","journal-title":"JAMA Surgery"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0007|cit7","volume-title":"The Use of Antibiotics vs Appendectomies for Uncomplicated Acute Appendicitis [Masters thesis]","author":"Bervell","year":"2019"},{"issue":"2","key":"10.1002\/14651858.CD015038.pub2-BIB0008|cit8","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s13304-018-00614-z","article-title":"Never put equipoise in appendix! Final results of ASAA (antibiotics vs. surgery for uncomplicated acute appendicitis in adults) randomized controlled trial","volume":"71","author":"Ceresoli","year":"2019","journal-title":"Updates in Surgery"},{"issue":"5","key":"10.1002\/14651858.CD015038.pub2-BIB0009|cit9","doi-asserted-by":"publisher","first-page":"346","DOI":"10.18535\/jmscr\/v8i5.64","article-title":"Antibiotics versus a emergency open appendectomy conservative management \u2013 a primary treatment of uncomplicated acute appendicitis: a randomized controlled trial","volume":"8","author":"Chauhan","year":"2020","journal-title":"Journal of Medical Science and Clinical Research"},{"issue":"20","key":"10.1002\/14651858.CD015038.pub2-BIB0010|cit10","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1056\/NEJMoa2014320","article-title":"A randomized trial comparing antibiotics with appendectomy for appendicitis","volume":"383","author":"CODA Collaborative","year":"2020","journal-title":"New England Journal of Medicine"},{"issue":"25","key":"10.1002\/14651858.CD015038.pub2-BIB0011|cit11","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1056\/NEJMc2116018","article-title":"Antibiotics versus appendectomy for acute appendicitis \u2013 longer-term outcomes","volume":"385","author":"CODA Collaborative","year":"2021","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD015038.pub2-BIB0012|cit12","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1097\/SLA.0000000000004785","article-title":"A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis: results of the COMMA trial","volume":"274","author":"O'Leary","year":"2021","journal-title":"Annals of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD015038.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/bjs.1800820207","article-title":"Randomized controlled trial of appendicectomy versus antibiotic therapy for acute appendicitis","volume":"82","author":"Eriksson","year":"1995","journal-title":"British Journal of Surgery"},{"issue":"5","key":"10.1002\/14651858.CD015038.pub2-BIB0014|cit14","first-page":"78","article-title":"Comparison of outcomes between antibiotics treatments versus appendectomy patients with uncomplicated acute appendicitis","volume":"31","author":"Khan","year":"2020","journal-title":"Medical Forum"},{"issue":"2","key":"10.1002\/14651858.CD015038.pub2-BIB0015|cit15","first-page":"120","article-title":"Comparison of antibiotic therapy and appendectomy in acute appendicitis","volume":"35","author":"Sabir","year":"2019","journal-title":"Pakistan Journal of Surgery"},{"issue":"6","key":"10.1002\/14651858.CD015038.pub2-BIB0016|cit16","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s00268-005-0304-6","article-title":"Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial","volume":"30","author":"Styrud","year":"2006","journal-title":"World Journal of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0017|cit17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.annemergmed.2016.08.446","article-title":"Antibiotics-first versus surgery for appendicitis: a US pilot randomized controlled trial allowing outpatient antibiotic management","volume":"70","author":"Talan","year":"2017","journal-title":"Annals of Emergency Medicine"},{"issue":"9777","key":"10.1002\/14651858.CD015038.pub2-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1016\/S0140-6736(11)60410-8","article-title":"Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial","volume":"377","author":"Vons","year":"2011","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD015038.pub2-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/bjs.6482","article-title":"Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients","volume":"96","author":"Hansson","year":"2009","journal-title":"British Journal of Surgery"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0020|cit20","first-page":"1659","article-title":"Antibiotics versus appendectomy for acute appendicitis: a randomized trial","volume":"2","author":"Laila","year":"2017","journal-title":"Clinical Surgery"},{"issue":"5","key":"10.1002\/14651858.CD015038.pub2-BIB0021|cit21","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1007\/s11605-009-0835-5","article-title":"Retracted article: conservative management of acute appendicitis","volume":"13","author":"Malik","year":"2009","journal-title":"Journal of Gastrointestinal Surgery"},{"issue":"5","key":"10.1002\/14651858.CD015038.pub2-BIB0022|cit22","first-page":"459","article-title":"Comparison of operative and non operative management of acute appendicitis","volume":"15","author":"Turhan","year":"2009","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0023|cit23","unstructured":"Antibiotics versus key-hole surgery for treatment of acute appendicitis (the TRAIN trial) trialsearch.who.int\/Trial2.aspx?TrialID=ACTRN12620000537954"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0024|cit24","unstructured":"Antibiotics vs surgery in acute appendicitis: an intention to treat prospective randomised controlled study, the ASAA-study www.clinicaltrialsregister.eu\/ctr-search\/trial\/2011-002977-44\/IT"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0025|cit25","unstructured":"Operative vs non-operative management of acute appendicitis and acute cholecystitis in COVID-19 positive patients clinicaltrials.gov\/ct2\/show\/NCT04748120"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1001\/jama.2018.13201","article-title":"Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial","volume":"320","author":"Salminen","year":"2018","journal-title":"JAMA"},{"issue":"10000","key":"10.1002\/14651858.CD015038.pub2-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1016\/S0140-6736(15)00275-5","article-title":"Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management","volume":"386","author":"Bhangu","year":"2015","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0028|cit28","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13017-016-0102-5","article-title":"Laparoscopic versus open appendectomy: a retrospective cohort study assessing outcomes and cost-effectiveness","volume":"11","author":"Biondi","year":"2016","journal-title":"World Journal of Emergency Surgery"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/s1092-9134(00)90011-x","article-title":"The pathology of acute appendicitis","volume":"4","author":"Carr","year":"2000","journal-title":"Annals of Diagnostic Pathology"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0030|cit30","doi-asserted-by":"publisher","first-page":"j2224","DOI":"10.1093\/bjsopen\/zrab058","article-title":"Montgomery and informed consent: where are we now?","volume":"357","author":"Chan","year":"2017","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD015038.pub2-BIB0031|cit31","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1213\/ANE.0000000000002237","article-title":"Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates","volume":"126","author":"Doleman","year":"2018","journal-title":"Anesthesia & Analgesia"},{"issue":"9","key":"10.1002\/14651858.CD015038.pub2-BIB0032|cit32","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s10151-019-02020-y","article-title":"Why most published meta-analysis findings are false","volume":"23","author":"Doleman","year":"2019","journal-title":"Techniques in Coloproctology"},{"issue":"4","key":"10.1002\/14651858.CD015038.pub2-BIB0033|cit33","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/jrsm.1414","article-title":"Funnel plots may show asymmetry in the absence of publication bias with continuous outcomes dependent on baseline risk: presentation of a new publication bias test","volume":"11","author":"Doleman","year":"2020","journal-title":"Research Synthesis Methods"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0034|cit34","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.bja.2021.01.004","article-title":"Methodologies for systematic reviews with meta-analysis of randomised clinical trials in pain, anaesthesia, and perioperative medicine","volume":"126","author":"Doleman","year":"2021","journal-title":"British Journal of Anaesthesia"},{"issue":"7109","key":"10.1002\/14651858.CD015038.pub2-BIB0035|cit35","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD015038.pub2-BIB0036|cit36","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1177\/145749690709600405","article-title":"Heredity and familial tendency of acute appendicitis","volume":"96","author":"Ergul","year":"2007","journal-title":"Scandinavian Journal of Surgery"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4137\/PMC.S14459","article-title":"Antibiotics and bacterial resistance in the 21st century","volume":"6","author":"Fair","year":"2014","journal-title":"Perspectives in Medicinal Chemistry"},{"issue":"2","key":"10.1002\/14651858.CD015038.pub2-BIB0038|cit38","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/SLA.0000000000002188","article-title":"The global incidence of appendicitis: a systematic review of population-based studies","volume":"266","author":"Ferris","year":"2017","journal-title":"Annals of Surgery"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0039|cit39","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1055\/s-2004-815775","article-title":"Appendicular colic and the non-inflamed appendix: fact or fiction?","volume":"14","author":"Fraser","year":"2004","journal-title":"European Journal of Pediatric Surgery"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"e00366","DOI":"10.1128\/mBio.00366-12","article-title":"Microbial composition of human appendices from patients following appendectomy","volume":"4","author":"Guinane","year":"2013","journal-title":"mBio"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0041|cit41","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/01.sla.0000103071.35986.c1","article-title":"Laparoscopic versus open appendectomy: outcomes comparison based on a large administrative database","volume":"239","author":"Guller","year":"2004","journal-title":"Annals of Surgery"},{"issue":"5","key":"10.1002\/14651858.CD015038.pub2-BIB0042|cit42","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/bjs.6482","article-title":"Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients","volume":"96","author":"Hansson","year":"2009","journal-title":"British Journal of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0043|cit43","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bja.2018.04.014","article-title":"Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6)","volume":"121","author":"Harper","year":"2018","journal-title":"British Journal of Anaesthesia"},{"issue":"4","key":"10.1002\/14651858.CD015038.pub2-BIB0044|cit44","doi-asserted-by":"publisher","first-page":"zrac100","DOI":"10.1093\/bjsopen\/zrac100","article-title":"Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis","volume":"6","author":"Herrod","year":"2022","journal-title":"BJS Open"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0045|cit45","unstructured":"Higgins JP Altman DG Sterne JA Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (updated June 2017). Cochrane Collaboration, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0046|cit46","unstructured":"Higgins JP Thomas J Chandler J Cumpston M Li T Page MJ Welch VA Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook"},{"issue":"8","key":"10.1002\/14651858.CD015038.pub2-BIB0047|cit47","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.jclinepi.2014.03.003","article-title":"In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias","volume":"67","author":"Hunter","year":"2014","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0048|cit48","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.mib.2019.10.008","article-title":"Antibiotics: past, present and future","volume":"51","author":"Hutchings","year":"2019","journal-title":"Current Opinion in Microbiology"},{"issue":"6","key":"10.1002\/14651858.CD015038.pub2-BIB0049|cit49","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/bjs.11999","article-title":"Global attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study","volume":"108","author":"Ielpo","year":"2021","journal-title":"British Journal of Surgery"},{"issue":"4","key":"10.1002\/14651858.CD015038.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"e95414","DOI":"10.1371\/journal.pone.0095414","article-title":"Culture-independent evaluation of the appendix and rectum microbiomes in children with and without appendicitis","volume":"9","author":"Jackson","year":"2014","journal-title":"PLOS One"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0051|cit51","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12876-015-0277-3","article-title":"Laparoscopic versus open appendectomy in patients with suspected appendicitis: a systematic review of meta-analyses of randomised controlled trials","volume":"15","author":"Jaschinski","year":"2015","journal-title":"BMC Gastroenterology"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0052|cit52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10151-020-02297-4","article-title":"The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study","volume":"15","author":"Javanmard-Emamghissi","year":"2020","journal-title":"Techniques in Coloproctology"},{"issue":"11","key":"10.1002\/14651858.CD015038.pub2-BIB0053|cit53","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1093\/bjs\/znab287","article-title":"Antibiotics as first-line alternative to appendicectomy in adult appendicitis: 90-day follow-up from a prospective, multicentre cohort study","volume":"108","author":"Javanmard-Emamghissi","year":"2021","journal-title":"British Journal of Surgery"},{"issue":"4","key":"10.1002\/14651858.CD015038.pub2-BIB0054|cit54","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.idc.2010.07.012","article-title":"Infectious causes of appendicitis","volume":"24","author":"Lamps","year":"2010","journal-title":"Infectious Disease Clinics of North America"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0055|cit55","unstructured":"Lefebvre C Glanville J Briscoe S Littlewood A Marshall C Metzendorf M Chapter 4: Searching for and selecting studies. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"issue":"6","key":"10.1002\/14651858.CD015038.pub2-BIB0056|cit56","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.ijsu.2011.06.005","article-title":"Laparoscopic versus open appendicectomy in obese patients","volume":"9","author":"Markar","year":"2011","journal-title":"International Journal of Surgery"},{"issue":"10","key":"10.1002\/14651858.CD015038.pub2-BIB0057|cit57","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1007\/s11605-012-1962-y","article-title":"Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children","volume":"16","author":"Markar","year":"2012","journal-title":"Journal of Gastrointestinal Surgery"},{"issue":"3","key":"10.1002\/14651858.CD015038.pub2-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004610.pub5","article-title":"Antibiotic treatment for Clostridium difficile-associated diarrhoea in adults","author":"Nelson","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0059|cit59","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/2049-3258-72-39","article-title":"Metaprop: a Stata command to perform meta-analysis of binomial data","volume":"72","author":"Nyaga","year":"2014","journal-title":"Archives of Public Health"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0060|cit60","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"3","key":"10.1002\/14651858.CD015038.pub2-BIB0061|cit61","doi-asserted-by":"publisher","first-page":"e216900","DOI":"10.1001\/jamasurg.2021.6900","article-title":"Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis","volume":"157","author":"Parsons","year":"2022","journal-title":"JAMA Surgery"},{"issue":"6","key":"10.1002\/14651858.CD015038.pub2-BIB0062|cit62","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1001\/jama.295.6.676","article-title":"Comparison of two methods to detect publication bias in meta-analysis","volume":"295","author":"Peters","year":"2006","journal-title":"JAMA"},{"issue":"6","key":"10.1002\/14651858.CD015038.pub2-BIB0063|cit63","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1097\/SLA.0000000000003225","article-title":"Antibiotic treatment and appendectomy for uncomplicated acute appendicitis in adults and children: a systematic review and meta-analysis","volume":"270","author":"Podda","year":"2019","journal-title":"Annals of Surgery"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0064|cit64","unstructured":"The Retraction Watch Database www.retractiondatabase.org"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0065|cit65","unstructured":"Review Manager 5 (RevMan 5) The Cochrane Collaboration 2020"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0066|cit66","unstructured":"Review Manager (RevMan) The Cochrane Collaboration 2021"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/cid\/ciw208","article-title":"Acute appendicitis in children is associated with a local expansion of Fusobacteria","volume":"63","author":"Rogers","year":"2016","journal-title":"Clinical Infectious Diseases"},{"issue":"11","key":"10.1002\/14651858.CD015038.pub2-BIB0068|cit68","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1002\/bjs.6736","article-title":"Genetic and environmental influences on the risk of acute appendicitis in twins","volume":"96","author":"Sadr Azodi","year":"2009","journal-title":"British Journal of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD015038.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13017-018-0179-0","article-title":"Prospective Observational Study on acute Appendicitis Worldwide (POSAW)","volume":"13","author":"Sartelli","year":"2018","journal-title":"World Journal of Emergency Surgery"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0070|cit70","unstructured":"Sch\u00fcnemann HJ Higgins JP Vist GE Glasziou P Akl EA Skoetz N Guyatt GH Chapter 14: Completing 'Summary of findings' tables and grading the certainty of the evidence. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"issue":"11","key":"10.1002\/14651858.CD015038.pub2-BIB0071|cit71","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1097\/DCR.0000000000001466","article-title":"Postoperative outcomes of patients with nonperforated gangrenous appendicitis: a national multicenter prospective cohort analysis","volume":"62","author":"Wijkerslooth","year":"2019","journal-title":"Diseases of the Colon and Rectum"},{"issue":"6","key":"10.1002\/14651858.CD015038.pub2-BIB0072|cit72","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1001\/archsurg.2012.568","article-title":"Laparoscopic vs open appendectomy in older patients","volume":"147","author":"Southgate","year":"2012","journal-title":"JAMA Surgery"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0073|cit73","unstructured":"Stata StataCorp 2017"},{"issue":"10","key":"10.1002\/14651858.CD015038.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1097\/INF.0000000000002434","article-title":"Microbiota of children with complex appendicitis: different composition and diversity of the microbiota in children with complex compared with simple appendicitis","volume":"38","author":"Bakx","year":"2019","journal-title":"Pediatric Infectious Disease Journal"},{"issue":"11","key":"10.1002\/14651858.CD015038.pub2-BIB0075|cit75","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/sim.1187","article-title":"How should meta-regression analyses be undertaken and interpreted?","volume":"21","author":"Thompson","year":"2002","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0076|cit76","unstructured":"Thorlund K Engstrom J Wetterslev J Brok J Imberger G Gluud C User Manual for Trial Sequential Analysis (TSA); 2nd edition. Copenhagen Trial Unit, 2018 Available from ctu.dk\/tsa\/learn-more 2018"},{"key":"10.1002\/14651858.CD015038.pub2-BIB0077|cit77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12876-016-0453-0","article-title":"Evidence of surgical outcomes fluctuates over time: results from a cumulative meta-analysis of laparoscopic versus open appendectomy for acute appendicitis","volume":"16","author":"Ukai","year":"2016","journal-title":"BMC Gastroenterology"},{"issue":"7","key":"10.1002\/14651858.CD015038.pub2-BIB0078|cit78","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1007\/s00268-021-06077-5","article-title":"The worldwide epidemiology of acute appendicitis: an analysis of the global health data exchange dataset","volume":"45","author":"Wickramasinghe","year":"2021","journal-title":"World Journal of Surgery"},{"issue":"3","key":"10.1002\/14651858.CD015038.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jpedsurg.2013.06.026","article-title":"Acute appendicitis in children is associated with an abundance of bacteria from the phylum Fusobacteria","volume":"49","author":"Zhong","year":"2014","journal-title":"Journal of Pediatric Surgery"},{"issue":"9","key":"10.1002\/14651858.CD015038.pub2-BIB0080|cit80","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015038","article-title":"Appendectomy versus antibiotic treatment for acute appendicitis","author":"Doleman","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD015038.pub2-BIB0081|cit81","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008359","article-title":"Appendectomy versus antibiotic treatment for acute appendicitis","author":"Wilms","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD015038.pub2-BIB0082|cit82","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008359.pub2","article-title":"Appendectomy versus antibiotic treatment for acute appendicitis","author":"Wilms","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T09:47:21Z","timestamp":1751276841000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD015038.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Colorectal Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":82,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd015038.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,29]]}}}