{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:19:20Z","timestamp":1791310760904,"version":"4.3.1"},"update-to":[{"DOI":"10.1002\/14651858.cd015245","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000}}],"reference-count":91,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd015245.pub2","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T14:07:26Z","timestamp":1677506846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Intratympanic corticosteroids for M\u00e9ni\u00e8re\u2019s disease"],"prefix":"10.1002","volume":"2023","author":[{"given":"Katie E","family":"Webster","sequence":"additional","affiliation":[{"name":"Cochrane ENT, Nuffield Department of Surgical Sciences; University of Oxford; Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambrose","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology - Head and Neck Surgery; University of Toronto; Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Galbraith","sequence":"additional","affiliation":[{"name":"Cochrane ENT; Nuffield Department of Surgical Sciences, University of Oxford; Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha A","family":"Harrington-Benton","sequence":"additional","affiliation":[{"name":"M\u00e9ni\u00e8re\u2019s Society; Wooton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Judd","sequence":"additional","affiliation":[{"name":"ENT Department; University Hospitals of Derby and Burton NHS Foundation Trust; Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Kaski","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto R","family":"Maarsingh","sequence":"additional","affiliation":[{"name":"Department of General Practice, Amsterdam UMC; Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute; Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"MacKeith","sequence":"additional","affiliation":[{"name":"ENT Department; Oxford University Hospitals NHS Foundation Trust; Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaydip","family":"Ray","sequence":"additional","affiliation":[{"name":"University of Sheffield; Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A","family":"Van Vugt","sequence":"additional","affiliation":[{"name":"Department of General Practice, Amsterdam UMC; Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute; Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Westerberg","sequence":"additional","affiliation":[{"name":"Otology & Neurotology; St. Paul's Rotary Hearing Clinic; Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J","family":"Burton","sequence":"additional","affiliation":[{"name":"Cochrane UK; Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"10.1002\/14651858.CD015245.pub2-BIB0001|cit1","first-page":"122","article-title":"OTO-104 in Meniere's disease patients: phase 3 results","volume":"157 (1 Suppl 1)","author":"Lambert","year":"2017","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0002|cit2","unstructured":"A prospective, randomized, double-blind, placebo-controlled, multicenter, phase 3 study of OTO-104 given as a single intratympanic injection in subjects with unilateral Meniere's disease (NCT02612337) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02612337"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0003|cit3","unstructured":"Otonomy Reports Results for AVERTS-1 Phase 3 Trial for OTIVIDEX\u2122 in Patients with M\u00e9ni\u00e8re's Disease https:\/\/investors.otonomy.com\/news-releases\/news-release-details\/otonomy-reports-results-averts-1-phase-3-trial-otividextm"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0004|cit4","unstructured":"A prospective, randomized, double-blind, placebo-controlled, multicentre, phase 3 efficacy and safety study of OTO-104 given as a single intratympanic injection in subjects with unilateral M\u00e9ni\u00e8re's disease https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/search?query=2015-004496-71 2021"},{"issue":"1 Suppl 1","key":"10.1002\/14651858.CD015245.pub2-BIB0005|cit5","first-page":"P120","article-title":"AVERTS-2 phase 3 results of Otividex in Meniere disease","volume":"159","author":"Phillips","year":"2018","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0006|cit6","unstructured":"Study of OTO-104 in subjects with unilateral Meniere's disease (NCT02717442) https:\/\/clinicaltrials.gov\/show\/NCT02717442"},{"issue":"3-4","key":"10.1002\/14651858.CD015245.pub2-BIB0007|cit7","first-page":"58","article-title":"Intratympanic dexamethasone delivery versus placebo in intractable Meniere disease","volume":"3","author":"Borghei","year":"2016","journal-title":"Academic Journal of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD015245.pub2-BIB0008|cit8","doi-asserted-by":"publisher","first-page":"Article number","DOI":"10.1186\/s43163-020-00018-0","article-title":"Comparison of the effect of three treatment interventions for the control of Meniere's disease: a randomized control trial","volume":"36","author":"El Shafei","year":"2020","journal-title":"Egyptian Journal of Otolaryngology"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0009|cit9","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.otohns.2005.05.010","article-title":"Dexamethasone inner ear perfusion by intratympanic injection in unilateral M\u00e9ni\u00e8re's disease: a two-year prospective, placebo-controlled, double-blind, randomized trial","volume":"133","author":"Garduno-Anaya","year":"2005","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0010|cit10","unstructured":"Garduno-Anaya MA Pane-Pianese C Couthino de Toledo H Dexamethasone inner ear perfusion in unilateral M\u00e9ni\u00e8re's disease: four years of prospective evaluation XVIII IFOS World Congress, Rome, Italy, 2005 June 25-30 2005"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"P136","DOI":"10.1016\/S0194-5998(03)01121-5","article-title":"Intratympanic dexamethasone in unilateral Meniere's disease: a two-year prospective trial","volume":"129","author":"Garduno-Anaya","year":"2003","journal-title":"Otolaryngology - Head and Neck Surgery"},{"issue":"7","key":"10.1002\/14651858.CD015245.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1097\/MAO.0b013e318263d35d","article-title":"A randomized, double-blind, placebo-controlled clinical study to assess safety and clinical activity of OTO-104 given as a single intratympanic injection in patients with unilateral M\u00e9ni\u00e8re's disease","volume":"33","author":"Lambert","year":"2012","journal-title":"Otology & Neurotology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0013|cit13","unstructured":"OTO-104 for the treatment of Meniere's disease (NCT01412177) https:\/\/clinicaltrials.gov\/show\/NCT01412177"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1097\/MAO.0000000000001227","article-title":"Intratympanic sustained-exposure dexamethasone thermosensitive gel for symptoms of M\u00e9ni\u00e8re's disease: randomized phase 2b safety and efficacy trial","volume":"37","author":"Lambert","year":"2016","journal-title":"Otology & Neurotology"},{"issue":"1 Suppl 1","key":"10.1002\/14651858.CD015245.pub2-BIB0015|cit15","first-page":"108","article-title":"Ph2b efficacy and safety of intratympanic OTO-104 in Meniere's disease","volume":"153","author":"Lambert","year":"2015","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0016|cit16","unstructured":"OTO-104 for the treatment of Meniere's disease (NCT01412177) https:\/\/clinicaltrials.gov\/show\/NCT01412177"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0017|cit17","unstructured":"A 6-month, prospective, randomized, multicenter, placebo-controlled safety study of OTO-104 given at 3-month intervals by intratympanic injection in subjects with unilateral Meniere's disease followed by a 6-month open-label extension (NCT02265393) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02265393"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0018|cit18","unstructured":"The safety of local application of dexamethasone (a corticosteroid) in the ear of people with Meniere's disease (EUCTR2014-001337-86-GB) http:\/\/www.who.int\/trialsearch\/Trial2.aspx?TrialID=EUCTR2014-001337-86-GB\u00a0"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0019|cit19","unstructured":"A study to see of local application (in the ear) of dexamethasone (a corticosteroid) to people with Meniere's disease could help with their symptoms and if it is safe to use (EUCTR2018-001464-35-ES) https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/search?query=eudract_number:2018-001464-35 2019"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0020|cit20","unstructured":"A study to see of local application (in the ear) of dexamethasone (a corticosteroid) to people with Meniere's disease could help with their symptoms and if it is safe to use (EUCTR2018-001464-35-GB) http:\/\/www.who.int\/trialsearch\/Trial2.aspx?TrialID=EUCTR2018-001464-35-GB 2018"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0021|cit21","unstructured":"Phase 3 study of OTO-104 in subjects with unilateral Meniere's disease (NCT03664674) https:\/\/clinicaltrials.gov\/show\/nct03664674"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0022|cit22","unstructured":"Otonomy announces top-line results for the phase 3 clinical trial of OTIVIDEX\u00ae in patients with M\u00e9ni\u00e8re's disease https:\/\/investors.otonomy.com\/news-releases\/news-release-details\/otonomy-announces-top-line-results-phase-3-clinical-trial 2021"},{"issue":"1","key":"10.1002\/14651858.CD015245.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5935\/0946-5448.20170005","article-title":"Short term results of intra tympanic gentamicin and dexamethasone on hearing and tinnitus in Meniere's disease: a case control study","volume":"21","author":"Ul Shamas","year":"2017","journal-title":"International Tinnitus Journal"},{"issue":"9","key":"10.1002\/14651858.CD015245.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00405-006-0065-3","article-title":"Intratympanic steroid therapy for inner ear diseases, a review of the literature","volume":"263","author":"Alles","year":"2006","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"issue":"5","key":"10.1002\/14651858.CD015245.pub2-BIB0025|cit25","first-page":"511","article-title":"Treatment of labyrinthine vertigo","volume":"16","author":"Conde Jahn","year":"1965","journal-title":"Acta Oto-rino-laringologica Ibero-americana"},{"issue":"9","key":"10.1002\/14651858.CD015245.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/MAO.0000000000001555","article-title":"Nocebo effect in Meniere's disease: a meta-analysis of placebo-controlled randomized controlled trials","volume":"38","author":"Dimitriadis","year":"2017","journal-title":"Otology & Neurotology"},{"issue":"11","key":"10.1002\/14651858.CD015245.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/000331976501601102","article-title":"Pathogenesis and management of Meniere's syndrome in terms of microcirculation. Pharmacologic decompression of the endolymphatic hydrops","volume":"16","author":"Godlowski","year":"1965","journal-title":"Angiology"},{"issue":"8","key":"10.1002\/14651858.CD015245.pub2-BIB0028|cit28","first-page":"1781","article-title":"Clinical effect of prootic and opisthotic injection of dexamethasone and gentamicin in Meniere disease therapy","volume":"15","author":"Guo","year":"2016","journal-title":"Tropical Journal of Pharmaceutical Research"},{"issue":"1","key":"10.1002\/14651858.CD015245.pub2-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s00415-020-10320-9","article-title":"Effects of intratympanic gentamicin and intratympanic glucocorticoids in Meniere's disease: a network meta-analysis","volume":"269","author":"Hao","year":"2022","journal-title":"Journal of Neurology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0030|cit30","unstructured":"Kitahara T Kubo T Kitahara M Effects of intra-endolymphatic sac application of large doses of steroids for intractable Meniere's Disease: a randomized controlled trial 26th Politzer Society Annual Meeting. Cleveland, Ohio, USA, 2007 October 13-16 2007 Abstract No. 106"},{"issue":"5","key":"10.1002\/14651858.CD015245.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/MLG.0b013e3181651c4a","article-title":"Effects of endolymphatic sac drainage with steroids for intractable Meniere's disease: a long-term follow-up and randomized controlled study","volume":"118","author":"Kitahara","year":"2008","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4103\/1012-5574.156098","article-title":"Intratympanic dexamethasone injection in Meniere's disease","volume":"31","author":"Maksoud","year":"2015","journal-title":"Egyptian Journal of Otolaryngology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0033|cit33","unstructured":"A 6-month extension study of OTO-104 in Meniere's disease https:\/\/ClinicalTrials.gov\/show\/NCT02768662"},{"issue":"3","key":"10.1002\/14651858.CD015245.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.joto.2017.06.002","article-title":"Intratympanic corticosteroids in Meniere's disease: a mini-review","volume":"12","author":"Patel","year":"2017","journal-title":"Journal of Otology"},{"issue":"7","key":"10.1002\/14651858.CD015245.pub2-BIB0035|cit35","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008514.pub2","article-title":"Intratympanic steroids for Meniere's disease or syndrome","author":"Phillips","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"242","key":"10.1002\/14651858.CD015245.pub2-BIB0036|cit36","first-page":"759","article-title":"Meniere's disease","volume":"207","author":"Richards","year":"1971","journal-title":"Practitioner"},{"issue":"9","key":"10.1002\/14651858.CD015245.pub2-BIB0037|cit37","first-page":"386","article-title":"Treatment of Morbus Meniere - transtympanic infusion of Lidocain, a corticosteroid solution, into the tympanic cavity","volume":"36","author":"Sakata","year":"1988","journal-title":"HNO"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0038|cit38","first-page":"196","article-title":"Dexamethasone inner ear perfusion for the treatment of Meniere's disease: a prospective, randomized, double-blind, crossover trial","volume":"19","author":"Silverstein","year":"1998","journal-title":"American Journal of Otology"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/coa.12449","article-title":"Intratympanic therapy in Meniere's syndrome or disease: up to date evidence for clinical practice","volume":"40","author":"Syed","year":"2015","journal-title":"Clinical Otolaryngology"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0040|cit40","first-page":"297","article-title":"Outcome and quality of life after intratympanic therapy for control of Meniere's disease","volume":"25","author":"Thabet","year":"2008","journal-title":"Benha Medical Journal"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0041|cit41","doi-asserted-by":"crossref","unstructured":"Committee on Hearing and Equilibrium Guidelines for the Diagnosis and Evaluation of Therapy in Meniere's Disease Otolaryngology \u2013 Head and Neck Surgery 1995 113 3 181 5","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0042|cit42","first-page":"1462","article-title":"Meniere's disease: criteria for diagnosis and evaluation of therapy for reporting","volume":"76","author":"Committee on Hearing and Equilibrium","year":"1972","journal-title":"Transactions of the American Academy of Ophthalmology and Otolaryngology"},{"issue":"9","key":"10.1002\/14651858.CD015245.pub2-BIB0043|cit43","doi-asserted-by":"publisher","first-page":"e0237523","DOI":"10.1371\/journal.pone.0237523","article-title":"Pharmacologic and surgical therapies for patients with Meniere's disease: a systematic review and network meta-analysis","volume":"15","author":"Ahmadzai","year":"2020","journal-title":"PLOS One"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0044|cit44","first-page":"225","article-title":"Treatment of Meniere's disease with intratympanic dexamethazone plus high dosage of betahistine","volume":"37","author":"Albu","year":"2016","journal-title":"American Journal of Otolaryngology - Head and Neck Medicine and Surgery"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/archneur.58.7.1151","article-title":"Prosper M\u00e9ni\u00e8re and his disease","volume":"58","author":"Baloh","year":"2001","journal-title":"Archives of Neurology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11882-012-0258-3","article-title":"Is allergy related to Meniere's disease?","volume":"12","author":"Banks","year":"2012","journal-title":"Current Allergy and Asthma Reports"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000475875","article-title":"Population-based study on the epidemiology of M\u00e9ni\u00e8re's disease","volume":"22","author":"Bruderer","year":"2017","journal-title":"Audiology & Neuro-otology"},{"issue":"4","key":"10.1002\/14651858.CD015245.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/coa.13350","article-title":"Different medications for the treatment of Meniere's disease by intratympanic injection: a systematic review and network meta-analysis","volume":"44","author":"Cao","year":"2019","journal-title":"Clinical Otolaryngology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/anae.13938","article-title":"Data fabrication and other reasons for non-random sampling in 5087 randomised, controlled trials in anaesthetic and general medical journals","volume":"72","author":"Carlisle","year":"2017","journal-title":"Anaesthesia"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0050|cit50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2147\/TACG.S59024","article-title":"The genetics of M\u00e9ni\u00e8re's disease","volume":"8","author":"Chiarella","year":"2015","journal-title":"Application of Clinical Genetics"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"e6863","DOI":"10.5867\/medwave.2017.6863","article-title":"Are intratympanic corticosteroids effective for Meniere's disease?","volume":"17","author":"Chuang-Chuang","year":"2017","journal-title":"Medwave"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/MAO.0000000000002255","article-title":"Intratympanic steroid for Meniere's disease: a systematic review","volume":"40","author":"Devantier","year":"2019","journal-title":"Otology & Neurotology"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1097\/00129492-200411000-00031","article-title":"Intratympanic steroid treatment: a review","volume":"25","author":"Doyle","year":"2004","journal-title":"Otology & Neurotology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0054|cit54","first-page":"455","article-title":"The physiologic role of corticosteroids in M\u00e9ni\u00e8re's disease","volume":"37","author":"Farhood","year":"2016","journal-title":"American Journal of Otolaryngology - Head and Neck Surgery"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000189783","article-title":"M\u00e9ni\u00e8re's disease is a viral neuropathy","volume":"71","author":"Gacek","year":"2009","journal-title":"ORL; Journal for Oto-rhino-laryngology and Its Related Specialties"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1001\/archotol.130.6.718","article-title":"The effects of transtympanic micropressure treatment in people with unilateral Meniere's disease","volume":"130","author":"Gates","year":"2004","journal-title":"Archives of Otolaryngology - Head and Neck Surgery"},{"issue":"10","key":"10.1002\/14651858.CD015245.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.autrev.2012.01.004","article-title":"Meniere's disease might be an autoimmune condition?","volume":"11","author":"Greco","year":"2012","journal-title":"Autoimmunity Reviews"},{"issue":"10","key":"10.1002\/14651858.CD015245.pub2-BIB0058|cit58","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1017\/S0022215100003947","article-title":"Observations on the pathology of M\u00e9ni\u00e8re's syndrome","volume":"53","author":"Hallpike","year":"1938","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0059|cit59","unstructured":"Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from training.cochrane.org\/handbook\/archive\/v5.1\/"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0060|cit60","unstructured":"Higgins JPT Thomas J Chandler J Cumpston M Li T Page MJ Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (updated February 2021). Cochrane, 2021 Available from www.training.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"g6544","DOI":"10.1136\/bmj.g6544","article-title":"Meniere's disease","volume":"349","author":"Harcourt","year":"2014","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD015245.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000286213","article-title":"Current-day prevalence of M\u00e9ni\u00e8re\u2019s syndrome","volume":"15","author":"Harris","year":"2010","journal-title":"Audiology & Neuro-otology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0063|cit63","first-page":"595","article-title":"Quantitative evaluation of dizziness characteristics and impact on quality of life","volume":"17","author":"Honrubia","year":"1996","journal-title":"American Journal of Otology"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000241894","article-title":"Intratympanic steroids for inner ear disorders: a review","volume":"14","author":"Hu","year":"2009","journal-title":"Audiology & Neuro-Otology"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0065|cit65","doi-asserted-by":"publisher","first-page":"644","DOI":"10.3109\/00016480903382808","article-title":"Long-term course of Meni\u00e8re's disease revisited","volume":"130","author":"Huppert","year":"2010","journal-title":"Acta Oto-Laryngologica"},{"issue":"4","key":"10.1002\/14651858.CD015245.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1001\/archotol.1990.01870040046011","article-title":"The development of the Dizziness Handicap Inventory","volume":"116","author":"Jacobsen","year":"1990","journal-title":"Archives of Otolaryngology - Head & Neck Surgery"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0067|cit67","first-page":"804","article-title":"A screening version of the Dizziness Handicap Inventory","volume":"19","author":"Jacobsen","year":"1998","journal-title":"American Journal of Otology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Menie\u0300re\u2019s disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"Journal of Vestibular Research"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/AUD.0b013e31822f67c0","article-title":"The Tinnitus Functional Index: Development of a new clinical measure for chronic, intrusive tinnitus","volume":"33","author":"Meikle","year":"2012","journal-title":"Ear and Hearing"},{"issue":"4","key":"10.1002\/14651858.CD015245.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/000348949910800403","article-title":"Measuring the effects of Menieres Disease: results of the Patient-Oriented Severity Index (MD POSI) Version 1","volume":"108","author":"Murphy","year":"1999","journal-title":"Annals of Otology, Rhinology and Laryngology"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archotol.1996.01890140029007","article-title":"Development of the Tinnitus Handicap Inventory","volume":"122","author":"Newman","year":"1996","journal-title":"Archives of Otolaryngology--Head and Neck Surgery"},{"issue":"S91","key":"10.1002\/14651858.CD015245.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005537-199907001-00001","article-title":"Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application","volume":"109","author":"Parnes","year":"1999","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1002\/14651858.CD015245.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0194-5998(96)70133-X","article-title":"Receptors for glucocorticoids in the human inner ear","volume":"115","author":"Rarey","year":"1996","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/cge.12150","article-title":"Familial clustering and genetic heterogeneity in Meniere\u2019s disease","volume":"85","author":"Requena","year":"2014","journal-title":"Clinical Genetics"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0075|cit75","unstructured":"Review Manager (RevMan) Nordic Cochrane Centre, The Cochrane Collaboration 2020"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/00129492-200211000-00022","article-title":"Factors influencing quality of life in patients with M\u00e9ni\u00e8re's disease, identified by a multidimensional approach","volume":"23","author":"S\u00f6derman","year":"2002","journal-title":"Otology & Neurotology"},{"issue":"3","key":"10.1002\/14651858.CD015245.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00002060-199905000-00009","article-title":"Short form of the Dizziness Handicap Inventory: construction and validation through Rasch analysis","volume":"78","author":"Tesio","year":"1999","journal-title":"American Journal of Physical Medicine and Rehabilitation"},{"issue":"3","key":"10.1002\/14651858.CD015245.pub2-BIB0078|cit78","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1097\/AUD.0000000000000264","article-title":"The cost of M\u00e9ni\u00e8re's disease: a novel multisource approach","volume":"37","author":"Tyrrell","year":"2016","journal-title":"Ear and Hearing"},{"issue":"6","key":"10.1002\/14651858.CD015245.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/jamia\/ocx053","article-title":"Identifying reports of randomized controlled trials (RCTs) via a hybrid machine learning and crowdsourcing approach","volume":"24","author":"Wallace","year":"2017","journal-title":"Journal of the American Medical Informatics Association"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Medical Research Methodology"},{"issue":"12","key":"10.1002\/14651858.CD015245.pub2-BIB0081|cit81","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015246","article-title":"Intratympanic aminoglycosides for M\u00e9ni\u00e8re\u2019s disease","author":"Webster","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD015245.pub2-BIB0082|cit82","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015171","article-title":"Systemic pharmacological interventions for M\u00e9ni\u00e8re\u2019s disease","author":"Webster","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0083|cit83","first-page":"0505","article-title":"M\u00e9ni\u00e8re's Disease","volume":"2015","author":"Wright","year":"2015","journal-title":"Clinical Evidence"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jclinepi.2021.02.012","article-title":"A proposed framework to guide evidence synthesis practice for meta-analysis with zero-events studies","volume":"135","author":"Xu","year":"2021","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0085|cit85","first-page":"2310","article-title":"Hearing organ of a patient who showed Meniere's symptoms\u00a0[Japanese]","volume":"44","author":"Yamakawa","year":"1938","journal-title":"Journal of the Otolaryngological Society of Japan"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2273.1992.tb01833.x","article-title":"Quantitative analysis of factors contributing to handicap and distress in vertiginous patients: a questionnaire study","volume":"17","author":"Yardley","year":"1992","journal-title":"Clinical Otolaryngology"},{"issue":"8","key":"10.1002\/14651858.CD015245.pub2-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0022-3999(92)90131-K","article-title":"Symptoms, anxiety and handicap in dizzy patients: development of the vertigo symptom scale","volume":"36","author":"Yardley","year":"1992","journal-title":"Journal of Psychometric Research"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0088|cit88","first-page":"1136","article-title":"A randomized controlled trial of exercise therapy for dizziness and vertigo in primary care","volume":"48","author":"Yardley","year":"1998","journal-title":"British Journal of General Practice"},{"issue":"2","key":"10.1002\/14651858.CD015245.pub2-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/0194599811403882","article-title":"Tinnitus Handicap Inventory for evaluating treatment effects: which changes are clinically relevant?","volume":"145","author":"Zeman","year":"2011","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD015245.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2021.03.026","article-title":"GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings","volume":"137","author":"Zeng","year":"2021","journal-title":"Journal of Clinical Epidemiology"},{"issue":"12","key":"10.1002\/14651858.CD015245.pub2-BIB0091|cit91","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015245","article-title":"Intratympanic corticosteroids for M\u00e9ni\u00e8re\u2019s disease","author":"Webster","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T04:19:48Z","timestamp":1736137188000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD015245.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane ENT Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,27]]},"references-count":91,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd015245.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,27]]}}}