{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:56:04Z","timestamp":1784688964135,"version":"3.55.0"},"update-to":[{"DOI":"10.1002\/14651858.cd015582","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000}}],"reference-count":113,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd015582.pub2","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T00:42:20Z","timestamp":1700872940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stem cell-based interventions for the treatment of stroke in newborn infants"],"prefix":"10.1002","volume":"2023","author":[{"given":"Matteo","family":"Bruschettini","sequence":"additional","affiliation":[{"name":"Paediatrics, Department of Clinical Sciences Lund; Lund University, Sk\u00e5ne University Hospital; Lund Sweden"},{"name":"Cochrane Sweden, Department of Research and Education; Lund University, Sk\u00e5ne University Hospital; Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Badura","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Children\u2019s Hospital Regensburg; Hospital St Hedwig of the Order of St John, University of Regensburg; Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Romantsik","sequence":"additional","affiliation":[{"name":"Paediatrics, Department of Clinical Sciences Lund; Lund University, Sk\u00e5ne University Hospital; Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"issue":"6","key":"10.1002\/14651858.CD015582.pub2-BIB0001|cit1","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/S1474-4422(22)00117-X","article-title":"Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study","volume":"21","author":"Baak","year":"2022","journal-title":"Lancet Neurology"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0002|cit2","unstructured":"Perinatal arterial stroke treated with stromal cells intranasally (PASSIoN) ClinicalTrials.gov\/show\/NCT03356821"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0003|cit3","unstructured":"Safety of autologous human umbilical cord blood treatment for perinatal arterial ischemic stroke ClinicalTrials.gov\/show\/NCT02460484"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0004|cit4","unstructured":"Feasibility and safety of umbilical cord blood transfusion in the treatment of neonatal cerebral ischemia and anemia ClinicalTrials.gov\/show\/NCT03352310"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0005|cit5","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1159\/000444905","article-title":"Stem cells for neonatal brain disorders","volume":"109","author":"Ahn","year":"2016","journal-title":"Neonatology"},{"issue":"12","key":"10.1002\/14651858.CD015582.pub2-BIB0006|cit6","doi-asserted-by":"publisher","first-page":"e0189895","DOI":"10.1371\/journal.pone.0189895","article-title":"Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: a systematic review and meta-analysis of preclinical studies","volume":"12","author":"Archambault","year":"2017","journal-title":"PLOS One"},{"issue":"12","key":"10.1002\/14651858.CD015582.pub2-BIB0007|cit7","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1002\/sctm.17-0126","article-title":"Mesenchymal stromal cell therapy in bronchopulmonary dysplasia: systematic review and meta-analysis of preclinical studies","volume":"6","author":"Augustine","year":"2017","journal-title":"Stem Cells Translational Medicine"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0008|cit8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/sctm.19-0193","article-title":"Are all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia","volume":"9","author":"Augustine","year":"2020","journal-title":"Stem Cells Translational Medicine"},{"issue":"7","key":"10.1002\/14651858.CD015582.pub2-BIB0009|cit9","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.jcyt.2013.03.005","article-title":"Risk of tumorigenicity in mesenchymal stromal cell-based therapies \u2013 bridging scientific observations and regulatory viewpoints","volume":"15","author":"Barkholt","year":"2013","journal-title":"Cytotherapy"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0010|cit10","doi-asserted-by":"publisher","first-page":"144","DOI":"10.2174\/1574888x11308020005","article-title":"Mesenchymal stem cells derived from Wharton's Jelly of the umbilical cord: biological properties and emerging clinical applications","volume":"8","author":"Batsali","year":"2013","journal-title":"Current Stem Cell Research & Therapy"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0011|cit11","volume-title":"Bayley Scales of Infant Development-II","author":"Bayley","year":"1993"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0012|cit12","volume-title":"Bayley Scales of Infant and Toddler Development","author":"Bayley","year":"2006"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0013|cit13","doi-asserted-by":"publisher","first-page":"e228884","DOI":"10.1001\/jamanetworkopen.2022.8884","article-title":"Association of perinatal and childhood ischemic stroke with attention-deficit\/hyperactivity disorder","volume":"5","author":"Bolk","year":"2022","journal-title":"JAMA Network Open"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0014|cit14","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s11121-013-0377-7","article-title":"Meta-analysis and subgroups","volume":"14","author":"Borenstein","year":"2013","journal-title":"Prevention Science"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0015|cit15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/pr.2016.172","article-title":"Delayed administration of neural stem cells after hypoxia-ischemia reduces sensorimotor deficits, cerebral lesion size, and neuroinflammation in neonatal mice","volume":"81","author":"Braccioli","year":"2017","journal-title":"Pediatric Research"},{"issue":"8","key":"10.1002\/14651858.CD015582.pub2-BIB0016|cit16","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013202.pub2","article-title":"Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants","author":"Bruschettini","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD015582.pub2-BIB0017|cit17","doi-asserted-by":"publisher","first-page":"e0115997","DOI":"10.1371\/journal.pone.0115997","article-title":"Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury","volume":"10","author":"Chen","year":"2015","journal-title":"PLOS One"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"32291","DOI":"10.1038\/srep32291","article-title":"Meta-analysis and systematic review of neural stem cells therapy for experimental ischemia stroke in preclinical studies","volume":"6","author":"Chen","year":"2016","journal-title":"Scientific Reports"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"679866","DOI":"10.3389\/fcell.2021.679866","article-title":"Integrative studies of human cord blood derived mononuclear cells and umbilical cord derived mesenchyme stem cells in ameliorating bronchopulmonary dysplasia","volume":"9","author":"Chen","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0020|cit20","unstructured":"Cochrane Effective Practice, Organisation of Care (EPOC). Data extraction and management. EPOC resources for review authors, 2017 epoc.cochrane.org\/resources\/epoc-resources-review-authors"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0021|cit21","unstructured":"Deeks JJ Higgins JP Altman DG Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.1 (updated September 2020). Cochrane, 2020 Available from training.cochrane.org\/handbook\/archive\/v6.1"},{"issue":"10","key":"10.1002\/14651858.CD015582.pub2-BIB0022|cit22","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrn.2017.107","article-title":"The use of brain organoids to investigate neural development and disease","volume":"18","author":"Di Lullo","year":"2017","journal-title":"Nature Reviews Neuroscience"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0023|cit23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"9","key":"10.1002\/14651858.CD015582.pub2-BIB0024|cit24","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/S2352-4642(18)30173-1","article-title":"Perinatal stroke: mechanisms, management, and outcomes of early cerebrovascular brain injury","volume":"2","author":"Dunbar","year":"2018","journal-title":"Lancet. Child & Adolescent Health"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0025|cit25","doi-asserted-by":"publisher","first-page":"100767","DOI":"10.1016\/j.spen.2019.08.003","article-title":"Perinatal stroke","volume":"32","author":"Dunbar","year":"2019","journal-title":"Seminars in Pediatric Neurology"},{"issue":"5","key":"10.1002\/14651858.CD015582.pub2-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"e2020013201","DOI":"10.1542\/peds.2020-013201","article-title":"Population based birth prevalence of disease-specific perinatal stroke","volume":"146","author":"Dunbar","year":"2020","journal-title":"Pediatrics"},{"issue":"7","key":"10.1002\/14651858.CD015582.pub2-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"841","DOI":"10.5966\/sctm.2014-0184","article-title":"Bystander effect fuels human induced pluripotent stem cell-derived neural stem cells to quickly attenuate early stage neurological deficits after stroke","volume":"4","author":"Eckert","year":"2015","journal-title":"Stem Cells Translational Medicine"},{"issue":"7109","key":"10.1002\/14651858.CD015582.pub2-BIB0028|cit28","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"756029","DOI":"10.3389\/fmed.2021.756029","article-title":"Cell therapy: types, regulation, and clinical benefits","volume":"8","author":"El-Kadiry","year":"2021","journal-title":"Frontiers in Medicine"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0030|cit30","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1002\/ana.21919","article-title":"Endothelial progenitor cell transplantation improves long-term stroke outcome in mice","volume":"67","author":"Fan","year":"2010","journal-title":"Annals of Neurology"},{"issue":"3","key":"10.1002\/14651858.CD015582.pub2-BIB0031|cit31","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1161\/STR.0000000000000183","article-title":"Management of stroke in neonates and children: a scientific statement from the American Heart Association\/American Stroke Association","volume":"50","author":"Ferriero","year":"2019","journal-title":"Stroke"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0032|cit32","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.molmed.2011.10.004","article-title":"The immunomodulatory capacity of mesenchymal stem cells","volume":"18","author":"Gebler","year":"2012","journal-title":"Trends in Molecular Medicine"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0033|cit33","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime)"},{"issue":"11","key":"10.1002\/14651858.CD015582.pub2-BIB0034|cit34","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1002\/sctm.17-0074","article-title":"Long-term recovery after endothelial colony-forming cells or human umbilical cord blood cells administration in a rat model of neonatal hypoxic-ischemic encephalopathy","volume":"6","author":"Grandvuillemin","year":"2017","journal-title":"Stem Cells Translational Medicine"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0035|cit35","volume-title":"The abilities of babies: a study of mental measurement","author":"Griffiths","year":"1954"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0036|cit36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S1474-4422(13)70261-8","article-title":"Mitochondria: hub of injury responses in the developing brain","volume":"13","author":"Hagberg","year":"2014","journal-title":"Lancet Neurology"},{"issue":"5","key":"10.1002\/14651858.CD015582.pub2-BIB0037|cit37","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jacc.2016.11.009","article-title":"Randomized comparison of allogeneic versus autologous mesenchymal stem cells for nonischemic dilated cardiomyopathy: POSEIDON-DCM trial","volume":"69","author":"Hare","year":"2017","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0038|cit38","unstructured":"Higgins JP Altman DG Sterne JA Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (updated June 2017). Cochrane, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0039|cit39","unstructured":"Higgins JP Li T Deeks JJ Chapter 6: Choosing effect measures and computing estimates of effect. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.1 (updated September 2020). Cochrane, 2020 Available from training.cochrane.org\/handbook\/archive\/V6.1"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0040|cit40","unstructured":"Higgins JP Thomas J Chandler J Cumpston M Li T Page M J Welch VA Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022 Available from www.training.cochrane.org\/handbook\/archive\/v6.3"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0041|cit41","doi-asserted-by":"publisher","first-page":"4826407","DOI":"10.1155\/2018\/4826407","article-title":"Intraparenchymal neural stem\/progenitor cell transplantation for ischemic stroke animals: a meta-analysis and systematic review","volume":"2018","author":"Huang","year":"2018","journal-title":"Stem Cells International"},{"issue":"5","key":"10.1002\/14651858.CD015582.pub2-BIB0042|cit42","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1517\/14712598.8.5.569","article-title":"Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies","volume":"8","author":"Iyer","year":"2008","journal-title":"Expert Opinion on Biological Therapy"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0043|cit43","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003311.pub3","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0044|cit44","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.09.008","article-title":"Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model","volume":"22","author":"Jensen","year":"2013","journal-title":"Journal of Stroke and Cerebrovascular Diseases"},{"issue":"12","key":"10.1002\/14651858.CD015582.pub2-BIB0045|cit45","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/cns.12441","article-title":"NF-\u03baB signaling is involved in the effects of intranasally engrafted human neural stem cells on neurofunctional improvements in neonatal rat hypoxic\u2013ischemic encephalopathy","volume":"21","author":"Ji","year":"2015","journal-title":"CNS Neuroscience and Therapeutics"},{"issue":"8","key":"10.1002\/14651858.CD015582.pub2-BIB0046|cit46","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/jcbfm.2010.32","article-title":"Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain","volume":"30","author":"Kawai","year":"2010","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"7","key":"10.1002\/14651858.CD015582.pub2-BIB0047|cit47","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1177\/0963689718781330","article-title":"Improvement by human oligodendrocyte progenitor cells of neurobehavioral disorders in an experimental model of neonatal periventricular leukomalacia","volume":"27","author":"Kim","year":"2018","journal-title":"Cell Transplant"},{"issue":"11","key":"10.1002\/14651858.CD015582.pub2-BIB0048|cit48","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1161\/STROKEAHA.113.000739","article-title":"Life after perinatal stroke","volume":"44","author":"Kirton","year":"2013","journal-title":"Stroke"},{"issue":"7","key":"10.1002\/14651858.CD015582.pub2-BIB0049|cit49","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41582-021-00503-x","article-title":"Perinatal stroke: mapping and modulating developmental plasticity","volume":"17","author":"Kirton","year":"2021","journal-title":"Nature Reviews Neurology"},{"issue":"10","key":"10.1002\/14651858.CD015582.pub2-BIB0050|cit50","doi-asserted-by":"publisher","first-page":"e47559","DOI":"10.1371\/journal.pone.0047559","article-title":"Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials","volume":"7","author":"Lalu","year":"2012","journal-title":"PLOS One"},{"issue":"5","key":"10.1002\/14651858.CD015582.pub2-BIB0051|cit51","doi-asserted-by":"publisher","first-page":"e00972","DOI":"10.1002\/brb3.972","article-title":"Human iNPC therapy leads to improvement in functional neurologic outcomes in a pig ischemic stroke model","volume":"8","author":"Lau","year":"2018","journal-title":"Brain and Behaviour"},{"issue":"8","key":"10.1002\/14651858.CD015582.pub2-BIB0052|cit52","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1161\/STROKEAHA.107.483743","article-title":"Acutely and retrospectively diagnosed perinatal stroke: a population-based study","volume":"38","author":"Laugesaar","year":"2007","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0053|cit53","unstructured":"Lehnerer V Roidl A Romantsik O Guzman R Wellmann S Bruschettini M Mesenchymal stem cell therapy in perinatal arterial ischemic stroke: systematic review of preclinical studies Pediatric Research 10.1038\/s41390-022-02208-3 35906311"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0054|cit54","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1212\/wnl.59.4.514","article-title":"Human marrow stromal cell therapy for stroke in rat","volume":"59","author":"Li","year":"2002","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0055|cit55","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13045-015-0130-8","article-title":"Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy","volume":"8","author":"Li","year":"2015","journal-title":"Journal of Hematology Oncology"},{"issue":"8","key":"10.1002\/14651858.CD015582.pub2-BIB0056|cit56","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/ene.13337","article-title":"Prenatal, perinatal and neonatal risk factors for perinatal arterial ischaemic stroke: a systematic review and meta-analysis","volume":"24","author":"Li","year":"2017","journal-title":"European Journal of Neurology"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0057|cit57","doi-asserted-by":"publisher","first-page":"8510805","DOI":"10.1155\/2017\/8510805","article-title":"Enhancement of mitochondrial transfer by antioxidants in human mesenchymal stem cells","volume":"2017","author":"Li","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0058|cit58","doi-asserted-by":"publisher","first-page":"591693","DOI":"10.3389\/fped.2020.591693","article-title":"The potential of mesenchymal stromal cell as therapy in neonatal diseases","volume":"8","author":"Liau","year":"2020","journal-title":"Frontiers in Pediatrics"},{"issue":"7","key":"10.1002\/14651858.CD015582.pub2-BIB0059|cit59","doi-asserted-by":"publisher","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLOS Medicine"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0060|cit60","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mvr.2014.01.008","article-title":"Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia-reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer","volume":"92","author":"Liu","year":"2014","journal-title":"Microvascular Research"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0061|cit61","first-page":"26","article-title":"What do we know about perinatal stroke? A review of current practices, outcomes, and future directions","volume":"1","author":"Mailo","year":"2021","journal-title":"Pediatric Stroke"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0062|cit62","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12974-018-1089-5","article-title":"Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury","volume":"15","author":"McDonald","year":"2018","journal-title":"Journal of Neuroinflammation"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0063|cit63","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jclinepi.2016.01.021","article-title":"PRESS peer review of electronic search strategies: 2015 Guideline Statement","volume":"75","author":"McGowan","year":"2016","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0064|cit64","volume-title":"PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Explanation and Elaboration (PRESS E&E)","author":"McGowan","year":"2016"},{"issue":"3","key":"10.1002\/14651858.CD015582.pub2-BIB0065|cit65","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1053\/j.semperi.2015.12.002","article-title":"Stem cell-based therapies for the newborn lung and brain: possibilities and challenges","volume":"40","author":"Mitsialis","year":"2016","journal-title":"Seminars Perinatology"},{"issue":"5","key":"10.1002\/14651858.CD015582.pub2-BIB0066|cit66","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1002\/ana.21936","article-title":"Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study","volume":"67","author":"Moharir","year":"2010","journal-title":"Annals of Neurology"},{"issue":"8","key":"10.1002\/14651858.CD015582.pub2-BIB0067|cit67","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1080\/14767058.2017.1405387","article-title":"Upcycling umbilical cords: bridging regenerative medicine with neonatology","volume":"32","author":"Moreira","year":"2019","journal-title":"Journal of Maternal-Fetal & Neonatal Medicine"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0068|cit68","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/jnc.15267","article-title":"Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: role of mitochondria, inflammation, and reactive oxygen species","volume":"158","author":"Nair","year":"2021","journal-title":"Journal of Neurochemistry"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0069|cit69","unstructured":"Umbilical cord derived mesenchymal stem cells therapy in hypoxic ischemic encephalopathy clinicaltrials.gov\/ct2\/show\/NCT01962233"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0070|cit70","unstructured":"Neural progenitor cell and paracrine factors to treat hypoxic ischemic encephalopathy clinicaltrials.gov\/ct2\/show\/NCT02854579"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0071|cit71","unstructured":"Efficacy and safety of pneumostem\u00ae for IVH in premature infants (phase 2a) clinicaltrials.gov\/ct2\/show\/NCT02890953"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0072|cit72","unstructured":"Study of hCT-MSC in newborn infants with moderate or severe HIE clinicaltrials.gov\/ct2\/show\/NCT03635450"},{"issue":"20","key":"10.1002\/14651858.CD015582.pub2-BIB0073|cit73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41536-019-0082-7","article-title":"Trends in clinical trials for stroke by cell therapy: data mining ClinicalTrials.gov and the ICTRP portal site","volume":"4","author":"Negoro","year":"2019","journal-title":"NPJ Regenerative Medicine"},{"issue":"3","key":"10.1002\/14651858.CD015582.pub2-BIB0074|cit74","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/S1474-4422(04)00679-9","article-title":"Stroke in newborn infants","volume":"3","author":"Nelson","year":"2004","journal-title":"Lancet Neurology"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0075|cit75","doi-asserted-by":"publisher","first-page":"4061516.eCollec","DOI":"10.1155\/2020\/4061516","article-title":"Multimodal therapeutic effects of neural precursor cells derived from human-induced pluripotent stem cells through episomal plasmid-based reprogramming in a rodent model of ischemic stroke","volume":"2020","author":"Oh","year":"2020","journal-title":"Stem Cells International"},{"issue":"6","key":"10.1002\/14651858.CD015582.pub2-BIB0076|cit76","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/stem.1104","article-title":"Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain","volume":"30","author":"Oki","year":"2012","journal-title":"Stem Cells"},{"issue":"3","key":"10.1002\/14651858.CD015582.pub2-BIB0077|cit77","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3727\/096368916X694193","article-title":"Mesenchymal stem cells: the magic cure for intraventricular hemorrhage?","volume":"26","author":"Park","year":"2017","journal-title":"Cell Transplantation"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-4939-1118-9_13","volume-title":"Perinatal Stem Cells","author":"Parolini","year":"2014"},{"issue":"11","key":"10.1002\/14651858.CD015582.pub2-BIB0079|cit79","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011932.pub2","article-title":"Mesenchymal stem cells for the prevention and treatment of bronchopulmonary dysplasia in preterm infants","author":"Pierro","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4Pt2","key":"10.1002\/14651858.CD015582.pub2-BIB0080|cit80","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/pr.2011.59","article-title":"Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy","volume":"71","author":"Pimentel-Coelho","year":"2012","journal-title":"Pediatric Research"},{"issue":"9","key":"10.1002\/14651858.CD015582.pub2-BIB0081|cit81","doi-asserted-by":"publisher","first-page":"e0138680","DOI":"10.1371\/journal.pone.0138680","article-title":"Preterm cord blood contains a higher proportion of immature hematopoietic progenitors compared to term sample","volume":"10","author":"Podesta","year":"2015","journal-title":"PLOS One"},{"issue":"3","key":"10.1002\/14651858.CD015582.pub2-BIB0082|cit82","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1542\/peds.2007-0336","article-title":"Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke","volume":"120","author":"Raju","year":"2007","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0083|cit83","unstructured":"Review Manager Web (RevMan Web) The Cochrane Collaboration 2022"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0084|cit84","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013201.pub3","article-title":"Stem cell-based interventions for the prevention and treatment of intraventricular haemorrhage and encephalopathy of prematurity in preterm infants","author":"Romantsik","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0085|cit85","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3233\/NPM-200597","article-title":"Epidemiology and pathogenesis of stroke in preterm infants: a systematic review","volume":"15","author":"Roy","year":"2022","journal-title":"Journal of Neonatal-Perinatal Medicine"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-4939-1118-9_25","volume-title":"Perinatal Stem Cells","author":"Sanberg","year":"2014"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0087|cit87","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3389\/fneur.2018.00987","article-title":"Administration of bone marrow-derived mononuclear cells contributed to the reduction of hypoxic-ischemic brain injury in neonatal rats","volume":"9","author":"Sato","year":"2018","journal-title":"Frontiers in Neurology"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0088|cit88","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G Oxman A Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach (updated October 2013). GRADE Working Group, 2013 Available from gdt.guidelinedevelopment.org\/app\/handbook\/handbook.html"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0089|cit89","unstructured":"Sch\u00fcnemann HJ Higgins JP Vist GE Glasziou P Akl EA Skoetz N Chapter 14: Completing 'Summary of findings' tables and grading the certainty of the evidence. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.1 (updated September 2020). Cochrane, 2020 Available from training.cochrane.org\/handbook\/archive\/v6.1"},{"issue":"6","key":"10.1002\/14651858.CD015582.pub2-BIB0090|cit90","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.3390\/ijms22063142","article-title":"Stem cell therapy for neonatal hypoxic-ischemic encephalopathy: a systematic review of preclinical studies","volume":"22","author":"Serrenho","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0091|cit91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0054-9","article-title":"Brain and spinal cord injury repair by implantation of human neural progenitor cells seeded onto polymer scaffolds","volume":"50","author":"Shin","year":"2018","journal-title":"Experimental & Molecular Medicine"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0092|cit92","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/stem.1024","article-title":"Implantation site and lesion topology determine efficacy of a human neural stem cell line in a rat model of chronic stroke","volume":"30","author":"Smith","year":"2012","journal-title":"Stem Cells"},{"issue":"12","key":"10.1002\/14651858.CD015582.pub2-BIB0093|cit93","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1002\/sctm.21-0243","article-title":"Neural stem cell treatment for perinatal brain injury: a systematic review and meta-analysis of preclinical studies","volume":"10","author":"Smith","year":"2021","journal-title":"Stem Cells Translational Medicine"},{"issue":"4","key":"10.1002\/14651858.CD015582.pub2-BIB0094|cit94","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/dmcn.14347","article-title":"Risk factors for perinatal arterial ischaemic stroke: a large case-control study","volume":"62","author":"Sorg","year":"2020","journal-title":"Developmental Medicine and Child Neurology"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0095|cit95","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s13224-017-1034-z","article-title":"Amniotic fluid stem cells: a new era in regenerative medicine","volume":"68","author":"Srivastava","year":"2018","journal-title":"Journal of Obstetrics and Gynaecology India"},{"issue":"3","key":"10.1002\/14651858.CD015582.pub2-BIB0096|cit96","doi-asserted-by":"publisher","first-page":"e163","DOI":"10.1542\/neo.22-3-e163","article-title":"Perinatal stroke: a practical approach to diagnosis and management","volume":"22","author":"Srivastava","year":"2021","journal-title":"NeoReviews"},{"issue":"11","key":"10.1002\/14651858.CD015582.pub2-BIB0097|cit97","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.1161\/STROKEAHA.121.034796","article-title":"Pediatric ischemic stroke and epilepsy: a nationwide cohort study","volume":"52","author":"Sundelin","year":"2021","journal-title":"Stroke"},{"issue":"7","key":"10.1002\/14651858.CD015582.pub2-BIB0098|cit98","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/sctm.20-0508","article-title":"Benefits and obstacles to cell therapy in neonates: the INCuBAToR (Innovative Neonatal Cellular Therapy for Bronchopulmonary Dysplasia: Accelerating Translation of Research)","volume":"10","author":"Th\u00e9baud","year":"2021","journal-title":"Stem Cells Translational Medicine"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0099|cit99","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s0304-3940(01)02331-x","article-title":"Grafting neural stem cells improved the impaired spatial recognition in ischemic rats","volume":"316","author":"Toda","year":"2001","journal-title":"Neuroscience Letters"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0100|cit100","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.stem.2015.06.007","article-title":"Stem cell therapies in clinical trials: progress and challenges","volume":"17","author":"Trounson","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0101|cit101","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neuroscience.2014.01.018","article-title":"Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke","volume":"263","author":"Tsuji","year":"2014","journal-title":"Neuroscience"},{"issue":"11","key":"10.1002\/14651858.CD015582.pub2-BIB0102|cit102","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1002\/stem.3080","article-title":"Intravenous bone marrow mononuclear cells for acute ischemic stroke: safety, feasibility, and effect size from a phase I clinical trial","volume":"37","author":"Vahidy","year":"2019","journal-title":"Stem Cells"},{"issue":"28","key":"10.1002\/14651858.CD015582.pub2-BIB0103|cit103","doi-asserted-by":"publisher","first-page":"9603","DOI":"10.1523\/JNEUROSCI.1835-10.2010","article-title":"Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function","volume":"30","author":"Velthoven","year":"2010","journal-title":"Journal of Neuroscience"},{"issue":"7","key":"10.1002\/14651858.CD015582.pub2-BIB0104|cit104","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.bbi.2011.03.021","article-title":"Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain","volume":"25","author":"Velthoven","year":"2011","journal-title":"Brain, Behavior, and Immunity"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0105|cit105","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/pr.2011.64","article-title":"Mesenchymal stem cells as a treatment for neonatal ischemic brain damage","volume":"71","author":"Velthoven","year":"2012","journal-title":"Pediatric Research"},{"issue":"5","key":"10.1002\/14651858.CD015582.pub2-BIB0106|cit106","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.pediatrneurol.2012.10.010","article-title":"Pluripotent possibilities: human umbilical cord blood cell treatment after neonatal brain injury","volume":"48","author":"Verina","year":"2013","journal-title":"Pediatric Neurology"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0107|cit107","doi-asserted-by":"publisher","first-page":"36","DOI":"10.7150\/ijms.21666","article-title":"Ethical and safety issues of stem cell-based therapy","volume":"15","author":"Volarevic","year":"2018","journal-title":"International Journal of Medical Sciences"},{"issue":"1-2","key":"10.1002\/14651858.CD015582.pub2-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/pr.2017.243","article-title":"Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells","volume":"83","author":"Wagenaar","year":"2018","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD015582.pub2-BIB0109|cit109","doi-asserted-by":"publisher","first-page":"749244","DOI":"10.3389\/fneur.2021.749244","article-title":"Transplanted human oligodendrocyte progenitor cells restore neurobehavioral deficits in a rat model of preterm white matter injury","volume":"12","author":"Wang","year":"2021","journal-title":"Frontiers in Neurology"},{"issue":"5","key":"10.1002\/14651858.CD015582.pub2-BIB0110|cit110","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1161\/STROKEAHA.111.000719","article-title":"Human umbilical vein endothelial cells protect against hypoxic-ischemic damage in neonatal brain via stromal cell-derived factor 1\/C-X-C chemokine receptor type 4","volume":"44","author":"Wu","year":"2013","journal-title":"Stroke"},{"issue":"1","key":"10.1002\/14651858.CD015582.pub2-BIB0111|cit111","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s13287-020-01834-0","article-title":"Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke","volume":"11","author":"Xia","year":"2020","journal-title":"Stem Cell Research and Therapy"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0112|cit112","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/stcltm\/szab024","article-title":"Umbilical cord blood and cord tissue-derived cell therapies for neonatal morbidities: current status and future challenges","volume":"1 1","author":"Zhou","year":"2022","journal-title":"Stem Cells Translational Medicine"},{"issue":"2","key":"10.1002\/14651858.CD015582.pub2-BIB0113|cit113","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015582","article-title":"Stem cell-based interventions for the treatment of stroke in newborn infants","author":"Bruschettini","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T17:17:26Z","timestamp":1733764646000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD015582.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Neonatal Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":113,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd015582.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]}}}