{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:18:29Z","timestamp":1787685509244,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"8","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd016375","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:33:36Z","timestamp":1787682816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurally adjusted ventilatory assist versus conventional mechanical ventilation for congenital diaphragmatic hernia in neonates"],"prefix":"10.1002","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7087-7006","authenticated-orcid":false,"given":"Can","family":"Aky\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics; Dokuz Eylul University Faculty of Medicine; \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-0591","authenticated-orcid":false,"given":"Ahmet Naci","family":"Emecen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Department of Public Health; Dokuz Eylul University Faculty of Medicine; \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Cracknell","sequence":"additional","affiliation":[{"name":"Cochrane Neonatal; Vermont Oxford Network; Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Fiander","sequence":"additional","affiliation":[{"name":"Cochrane Neonatal; Vermont Oxford Network; Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7390-5228","authenticated-orcid":false,"given":"Sandeep","family":"Shetty","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit; St George's Hospital NHS Foundation Trust; London UK"},{"name":"Department of Neonatology; City St. Georges' University; London UK"},{"name":"Department of Women and Children's Health; King's College London; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"White","sequence":"additional","affiliation":[{"name":"Department of Global, Public & Population Health & Policy; School of Health and \u00ad\u00adMedical Sciences, City St George\u2019s, University of London; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"3","key":"10.1002\/14651858.CD016375-BIB0001|cit1","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1213\/ANE.0000000000004324","article-title":"Update on congenital diaphragmatic hernia","volume":"131","author":"Chatterjee","year":"2020","journal-title":"Anesthesia and Analgesia"},{"issue":"3","key":"10.1002\/14651858.CD016375-BIB0002|cit2","doi-asserted-by":"publisher","first-page":"101649","DOI":"10.1016\/j.siny.2025.101649","article-title":"Cardiorespiratory transition in CDH","volume":"30","author":"Sankaran","year":"2025","journal-title":"Seminars in Fetal & Neonatal Medicine"},{"issue":"3","key":"10.1002\/14651858.CD016375-BIB0003|cit3","doi-asserted-by":"publisher","first-page":"101660","DOI":"10.1016\/j.siny.2025.101660","article-title":"\"Gentle\u201c cardio-respiratory management in congenital diaphragmatic hernia: time for a precision-medicine approach?","volume":"30","author":"Foth","year":"2025","journal-title":"Seminars in Fetal & Neonatal Medicine"},{"issue":"3","key":"10.1002\/14651858.CD016375-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"381","DOI":"10.5114\/aoms.2011.23400","article-title":"Neonatal ventilatory techniques \u2013 which are best for infants born at term?","volume":"7","author":"Chowdhury","year":"2011","journal-title":"Archives of Medical Science"},{"issue":"5","key":"10.1002\/14651858.CD016375-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00431-026-06888-5","article-title":"Randomised crossover trial of neurally adjusted ventilatory assist (NAVA) for neonates with congenital diaphragmatic hernias: the NAN-C study","volume":"185","author":"Shetty","year":"2026","journal-title":"European Journal of Pediatrics"},{"key":"10.1002\/14651858.CD016375-BIB0006|cit6","unstructured":"Work of breathing description in neonates with congenital diaphragmatic hernia in NAVA and in conventional ventilation (NAVA-DIAPH) https:\/\/clinicaltrials.gov\/study\/NCT03250793"},{"issue":"9","key":"10.1002\/14651858.CD016375-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1515\/jpm-2022-0199","article-title":"The use of neurally-adjusted ventilatory assist (NAVA) for infants with congenital diaphragmatic hernia (CDH)","volume":"50","author":"Poole","year":"2022","journal-title":"Journal of Perinatal Medicine"},{"key":"10.1002\/14651858.CD016375-BIB0008|cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-026-02649-2","article-title":"NAVA use in infants with established bronchopulmonary dysplasia, congenital diaphragmatic hernia, and those on ECMO: a narrative literature review","volume":"-","author":"Sanfilippo","year":"2026","journal-title":"Journal of Perinatology"},{"issue":"3","key":"10.1002\/14651858.CD016375-BIB0009|cit9","doi-asserted-by":"publisher","first-page":"101655","DOI":"10.1016\/j.siny.2025.101655","article-title":"In search of \"optimal care\": where should congenital diaphragmatic hernia be managed?","volume":"30","author":"Pollack","year":"2025","journal-title":"Seminars in Fetal & Neonatal Medicine"},{"key":"10.1002\/14651858.CD016375-BIB0010|cit10","unstructured":"McKenzie JE Brennan SE Ryan RE Thomson HJ Johnston RV Thomas J Chapter 3: Defining the criteria for including studies and how they will be grouped for the synthesis [last updated August 2023]. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook"},{"issue":"1","key":"10.1002\/14651858.CD016375-BIB0011|cit11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Systematic Reviews"},{"key":"10.1002\/14651858.CD016375-BIB0012|cit12","unstructured":"Higgins JP Thomas J Chandler J Cumpston M Li T Page MJ Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated August 2024). Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD016375-BIB0013|cit13","unstructured":"Reeves BC Deeks JJ Higgins JP Shea B Tugwell P Wells GA Chapter 24: Including non-randomized studies on intervention effects [last updated October 2019]. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD016375-BIB0014|cit14","unstructured":"Sterne JA Hern\u00e1n MA McAleenan A Reeves BC Higgins JP Chapter 25: Assessing risk of bias in a non-randomized study [last updated October 2019]. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD016375-BIB0015|cit15","unstructured":"Higgins JP Lasserson T Thomas J Flemyng E Churchill R Methodological expectations of Cochrane intervention reviews. Cochrane: London, Version August 2023 Available from https:\/\/community.cochrane.org\/mecir-manual"},{"key":"10.1002\/14651858.CD016375-BIB0016|cit16","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ (Clinical Research Ed.)"},{"key":"10.1002\/14651858.CD016375-BIB0017|cit17","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ (Clinical Research Ed.)"},{"key":"10.1002\/14651858.CD016375-BIB0018|cit18","unstructured":"ROBINS-I v2 tool https:\/\/www.riskofbias.info\/welcome\/robins-i-v2"},{"issue":"3","key":"10.1002\/14651858.CD016375-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/jrsm.1315","article-title":"Revisiting the need for a literature search narrative: a brief methodological note","volume":"9","author":"Cooper","year":"2018","journal-title":"Research Synthesis Methods"},{"key":"10.1002\/14651858.CD016375-BIB0020|cit20","unstructured":"Covidence Veritas Health Innovation 2025"},{"key":"10.1002\/14651858.CD016375-BIB0021|cit21","unstructured":"Review Manager (RevMan) The Cochrane Collaboration 2026"},{"key":"10.1002\/14651858.CD016375-BIB0022|cit22","unstructured":"RoB 2 Tool https:\/\/www.riskofbias.info\/welcome\/rob-2-0-tool\/current-version-of-rob-2"},{"key":"10.1002\/14651858.CD016375-BIB0023|cit23","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD016375-BIB0024|cit24","unstructured":"Higgins JP Li T Deeks JJ Chapter 6: Choosing effect measures and computing estimates of effect [last updated August 2023]. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook"},{"issue":"8","key":"10.1002\/14651858.CD016375-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1038\/s41372-021-01095-6","article-title":"New BPD-prevalence and risk factors for bronchopulmonary dysplasia\/mortality in extremely low gestational age infants \u226428 weeks","volume":"41","author":"Geetha","year":"2021","journal-title":"Journal of Perinatology"},{"issue":"3","key":"10.1002\/14651858.CD016375-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.anpedi.2021.03.002","article-title":"Epidemiology and risk factors for bronchopulmonary dysplasia in preterm infants born at or less than 32 weeks of gestation","volume":"96","author":"Sucasas Alonso","year":"2022","journal-title":"Anales de Pediatr\u00eda"},{"issue":"6","key":"10.1002\/14651858.CD016375-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/archdischild-2021-323573","article-title":"Online clinical tool to estimate risk of bronchopulmonary dysplasia in extremely preterm infants","volume":"107","author":"Greenberg","year":"2022","journal-title":"Archives of Disease in Childhood \u2013 Fetal and Neonatal Edition"},{"issue":"9","key":"10.1002\/14651858.CD016375-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1056\/NEJM199702273360901","article-title":"Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure","volume":"336","author":"The Neonatal Inhaled Nitric Oxide Study Group (NINOS)","year":"1997","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD016375-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"151888","DOI":"10.1016\/j.semperi.2024.151888","article-title":"Mechanical ventilation in special populations","volume":"48","author":"Zhang","year":"2024","journal-title":"Seminars in Perinatology"},{"key":"10.1002\/14651858.CD016375-BIB0030|cit30","doi-asserted-by":"crossref","unstructured":"Higgins JP Eldridge S Li T Chapter 23: Including variants on randomized trials (last updated October 2019). In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org","DOI":"10.1002\/9781119536604.ch23"},{"key":"10.1002\/14651858.CD016375-BIB0031|cit31","unstructured":"Page MJ Higgins JP Sterne JA Chapter 13: Assessing risk of bias due to missing evidence in a meta-analysis [last updated August 2024]. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD016375-BIB0032|cit32","unstructured":"Deeks JJ Higgins JP Altman DG McKenzie JE Veroniki AA Chapter 10: Analysing data and undertaking meta-analyses (last updated November 2024). In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 20244 Available from https:\/\/www.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD016375-BIB0033|cit33","unstructured":"McKenzie JE Brennan SE Chapter 12: Synthesizing and presenting findings using other methods [last updated October 2019]. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD016375-BIB0034|cit34","doi-asserted-by":"publisher","first-page":"l6890","DOI":"10.1136\/bmj.l6890","article-title":"Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline","volume":"368","author":"Campbell","year":"2020","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD016375-BIB0035|cit35","doi-asserted-by":"crossref","unstructured":"Reeves BC Deeks JJ Higgins JP Shea B Tugwell P Wells GA Chapter 24: Including non-randomized studies on intervention effects (last updated October 2019). In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s) . Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook","DOI":"10.1002\/9781119536604.ch24"},{"key":"10.1002\/14651858.CD016375-BIB0036|cit36","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G Oxman A Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach (updated October 2013). GRADE Working Group, 2013 Available from https:\/\/gdt.gradepro.org\/app\/handbook\/handbook.html"},{"key":"10.1002\/14651858.CD016375-BIB0037|cit37","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime) 2025"},{"key":"10.1002\/14651858.CD016375-BIB0038|cit38","unstructured":"Sch\u00fcnemann HJ Higgins JP Vist GE Glasziou P Akl EA Skoetz N Chapter 14: Completing \u2018Summary of findings\u2019 tables and grading the certainty of the evidence [last updated August 2023]. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024 Available from https:\/\/www.cochrane.org\/handbook"},{"issue":"4","key":"10.1002\/14651858.CD016375-BIB0039|cit39","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1136\/archdischild-2019-317501","article-title":"Core outcomes in neonatology: development of a core outcome set for neonatal research","volume":"105","author":"Webbe","year":"2019","journal-title":"Archives of Disease in Childhood - Fetal and Neonatal Edition"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:33:39Z","timestamp":1787682819000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD016375"}},"subtitle":[],"editor":[{"name":"Cochrane Central Editorial Service","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd016375","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]}}}